6239:CELE T01C1.2
gene id: 6239:CELE_T01C1.2
uniprot id: G5EGQ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at the comma stage and throughout larval stages and in adult.
messages: Expressed in AIM, RIC, AIZ, ADF, ADL, ASK, AWA, AUA, AIN, RIH (or RIR) and RIF head neurons and, in PVP, PVQ and DVA (or DVC) tail neurons, some intestinal cells, somatic gonad and vulva.
messages: May act as transcription activator (By similarity). Plays a role in neurogenesis by regulating neurite pruning between left and right AIM neurons and left and right RIF neurons during larval development (PubMed:16139210, PubMed:19561603). Regulates olfactory plasticity (PubMed:19561603).
messages: Nucleus
messages: The left and right AIM neurons and the left and right RIF neurons are connected by abnormal neurites in 40% and 80% of adults respectively (PubMed:16139210, PubMed:19561603). Fails to reduce chemotaxis to benzaldehyde after pre-exposure to benzaldehyde (PubMed:19561603). In mbr-1 and cam-1 double mutants, normal neurite pruning between left and right AIM neurons is restored (PubMed:19561603).

6239:CELE Y24F12A.1
gene id: 6239:CELE_Y24F12A.1
uniprot id: N1NTK1
uniprot id: Q9U2Q7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

6239:CELE F11E6.6
gene id: 6239:CELE_F11E6.6
uniprot id: Q9U3J7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K06C4.10
gene id: 6239:CELE_K06C4.10
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE K11E4.5
gene id: 6239:CELE_K11E4.5
uniprot id: Q9GTD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K10C8.3
gene id: 6239:CELE_K10C8.3
uniprot id: G5ECX8
uniprot id: G5EDV6
names: Similarity
messages: Belongs to the IST1 family.

6239:CELE K12G11.1
gene id: 6239:CELE_K12G11.1
uniprot id: G5EEA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE C25B8.6
gene id: 6239:CELE_C25B8.6
uniprot id: G5EET0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F01G10.10
gene id: 6239:CELE_F01G10.10
uniprot id: O17768
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

6239:CELE T12D8.7
gene id: 6239:CELE_T12D8.7
uniprot id: O45784
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed from the 4-cell stage through late gastrulation (at protein level) (PubMed:11566890). May be maternally expressed (PubMed:11566890).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced slightly in embryos (PubMed:11566890). Abolishes expression of taf-10, perhaps as a result of altered protein stability (PubMed:11566890). Reduces expression of a range of genes, including let-858, rps-5, hsp16.2, and pes-10, but has little or no effect on expression of cki-2 and sur-5 (PubMed:11566890).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-9 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex (PubMed:11566890).
messages: Throughout PMID:11566890, the gene name taf-10 is used instead of taf-9, based on an earlier nomenclature; readers should be aware to avoid confusion.

6239:CELE F58G6.3
gene id: 6239:CELE_F58G6.3
uniprot id: Q21009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6239:CELE F20B6.2
gene id: 6239:CELE_F20B6.2
uniprot id: Q19626
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Expressed in embryos, larvae and adults (PubMed:22426883). In embryos, expression begins at the end of gastrulation after the first cell cleavage (PubMed:22426883).
messages: Expressed ubiquitously (PubMed:22426883). Highly expressed in the H-shaped excretory cell, the excretory pore, the intestine, and hypodermal cells (PubMed:22426883). Expressed in the nervous system (PubMed:22426883). Expressed at low levels in muscles (PubMed:22426883).
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (Probable). Essential for the proper assembly and activity of V-ATPase (By similarity). Required maternally for early embryogenesis and zygotically during morphogenesis (PubMed:22426883). Specifically, involved in the clearance of apoptotic cell corpses in embryos (PubMed:22426883). Also, during embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion (PubMed:15866168). In neurons, required for necrotic cell death by promoting intracellular acidification (PubMed:16005300). Required for cell death induced by hypoxia (PubMed:16005300). Required for acidification of synaptic vesicles and the release of neurotransmitters from adult neurons (PubMed:22426883).
messages: RNAi-mediated knockdown causes hyperfusion of embryonic epidermal cells (PubMed:15866168). RNAi-mediated knockdown suppresses hypoxia-induced cell death, and, in a mec-4 (u231) mutant background, neurodegeneration of touch-receptor neurons (PubMed:16005300).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE ZC581.2
gene id: 6239:CELE_ZC581.2
uniprot id: O01773
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE T27C10.6
gene id: 6239:CELE_T27C10.6
uniprot id: Q9TZM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
messages: Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
messages: Expressed in cell bodies, but not in dendritic or axonal processes, of adult head neurons. Also present in non-neuronal tissues, such as the body wall musculature and the epithelial cells of the nematode vulva.
messages: Golgi apparatus

6239:CELE T09A5.2
gene id: 6239:CELE_T09A5.2
uniprot id: P45962
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

6239:CELE F49E2.4
gene id: 6239:CELE_F49E2.4
uniprot id: D0VWM4
uniprot id: Q20623
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W06B3.1
gene id: 6239:CELE_W06B3.1
uniprot id: Q9XXM2
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

6239:CELE Y39G10AR.2
gene id: 6239:CELE_Y39G10AR.2
uniprot id: Q95XP9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZWILCH family.
messages: Component of the RZZ complex composed of rod-1, czw-1 and zwl-1 (PubMed:18765790). Interacts with the spindly-like protein spdl-1 (PubMed:18765790). Interacts with NDC80 complex component ndc-80 (PubMed:24231804).
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:18765790). Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation (PubMed:18765790). Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18765790). The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790). To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804). The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804). Required for embryonic development (PubMed:18765790, PubMed:19109417).
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:18765790, PubMed:19109417). RNAi-mediated knockdown results in defective chromosome segregation, premature spindle pole separation and incorrectly attached kinetochores (PubMed:18765790). In addition, knl-1 localization to the spindle-associated rod-shaped structures but not to kinetochores is lost during anaphase of meiosis I (PubMed:20729837). RNAi-mediated knockdown also results in abolished targeting of the spindly-like protein spdl-1 to the kinetochore (PubMed:18765790).
messages: cell cortex
messages: kinetochore
messages: spindle

6239:CELE F44C8.11
gene id: 6239:CELE_F44C8.11
uniprot id: Q95X91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T12D8.6
gene id: 6239:CELE_T12D8.6
uniprot id: Q9XVI9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Arrest at the 1-cell stage embryo due to a cytokinesis defect characterized by a failure to form a contractile ring.
messages: Cytoplasm
messages: Expressed during embryogenesis in seam cells as well as in the dorsal and ventral hypodermal cells where it co-localizes with actin bundles.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: Required for cytokinesis and embryo elongation. May regulate myosin II complex formation and/or the association of myosin with actin. May be involved in the organization of mlc-4 and nmy-2 into bundles.
messages: cytoskeleton

6239:CELE Y23H5B.5
gene id: 6239:CELE_Y23H5B.5
uniprot id: Q9N477
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE T07F8.3
gene id: 6239:CELE_T07F8.3
uniprot id: Q95ZK7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed both maternally and zygotically throughout development and in adult hermaphrodites and males (at protein level).
messages: Expressed in the germline (at protein level). In adult hermaphrodites, first detected in the transition zone (TZ), weakly expressed in the early mitotic region and in pachytene germ cells, and becomes more abundantly expressed as germ cells enter diakinesis (at protein level). Expressed in primary spermatocytes, but not in secondary spermatocytes or adult sperm (at protein level).
messages: Interacts (via its KH1 domain) with gld-2. Isoform A but not isoform B interacts specifically with fbf-1 and fbf-2 in an RNA-independent manner. Isoform A interacts with gls-1 isoform C.
messages: Loss of both maternal and zygotic expression causes variable lethality, ranging from arrest during embryonic development to soon after hatching, and sterility due to early germline defects. In these animals the germline precursor cells Z2 and Z3 are smaller, divide more slowly and their descendants remain small and indistinct compared to their wild-type counterparts. In addition, some of these animals show somatic defects, including a protruding vulva, multiple vulvae or a reduction in animal size. In zygotic mutant adult hermaphrodites, most spermatogenic cells are blocked as primary spermatocytes, the number of spermatocytes appears lower than normal and spermatogenesis is delayed by several hours. Zygotic mutant homozygous adult males produce some spermatogenic cells, although these sperm are less well defined morphologically than normal. In addition, loss of maternal and zygotic expression results in adult males that produce enlarged granular cells that appear oocyte-like and show chromosomal bivalents typical of oocytes. In zygotic mutants the mitotic region is longer and has more nuclei than normal, the mitotic region/TZ boundary is shifted from 20 to an average of 27 or 28 nuclei and the boundaries between mitotic region and TZ and TZ and pachytene region are not sharp as in wild-type.
messages: Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis.
messages: The deletion mutant gld-3 (q730) makes no detectable GLD-3; it is predicted to generate an mRNA with a premature stop codon, which should be subject to NMD. The deletion mutant gld-3 (q741) removes the fbf-binding site from isoform A, but leaves the gld-2-binding site intact. Animals homozygous for gld-3 (7q41) enter meiosis, but are feminized. In addition, gld-3 protein that retains its gld-2-binding region, does not have the dramatic mitosis/meiosis delay seen in gld-3 null mutants. By contrast, sex determination was not normal; gld-3 (q741) males produced oocytes. Therefore, promotes meiosis primarily via its interaction with gld-2 whereas the sperm/oocyte decision relies on its interaction with fbf.
messages: perinuclear region

6239:CELE C36B1.4
gene id: 6239:CELE_C36B1.4
uniprot id: Q95005
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

6239:CELE F55B11.1
gene id: 6239:CELE_F55B11.1
uniprot id: O17892
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Peroxisome

6239:CELE R12C12.5
gene id: 6239:CELE_R12C12.5
uniprot id: Q21959
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE F56F4.5
gene id: 6239:CELE_F56F4.5
uniprot id: O01840
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Expressed in the AVA interneuron.
messages: Expression is detected as early as the larval L1 stage and continues into the adult stage.
messages: Membrane
messages: Neuron-specific, H(+)-coupled oligopeptide transporter with broad specificity towards di- and tripeptides in a Na(+) and Cl(-)-independent manner. Shows H(+) channel activity in the absence of peptide substrates.

6239:CELE F08C6.4
gene id: 6239:CELE_F08C6.4
uniprot id: G8JY63
uniprot id: Q19200
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

6239:CELE F11G11.9
gene id: 6239:CELE_F11G11.9
uniprot id: P91247
names: Domain
names: Induction
messages: Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue.
messages: Expression increased by knockdown of mpst-1.

6239:CELE C24H11.6
gene id: 6239:CELE_C24H11.6
uniprot id: Q9XVD2
names: Subunit
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.

6239:CELE F28F9.4
gene id: 6239:CELE_F28F9.4
uniprot id: Q94197
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C55C3.4
gene id: 6239:CELE_C55C3.4
uniprot id: Q18865
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE T06C12.9
gene id: 6239:CELE_T06C12.9
uniprot id: O18038
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE C06E1.4
gene id: 6239:CELE_C06E1.4
uniprot id: P34299
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Command interneurons of the locomotory control circuit (AIB, AVA, AVB, AVD, AVE and PVC) and motor neurons (RMD, RIM, SMD, AVG, PVQ and URY).
messages: Decreased frequency of reversals, suppression of hyperreversal phenotype of cni-1 mutants, decreased tactile response and increased osmotic avoidance (PubMed:24094107). Overall, display increased omega turn frequency following reversals, however deletion in AIB interneurons specifically results in decreased omega turn frequency (PubMed:27223098). Decreased nose touch responses (PubMed:27223098).
messages: Endoplasmic reticulum
messages: Glycosylated.
messages: Interacts with sol-1 (PubMed:14749834). Interacts with cni-1; the interaction negatively regulates export of glr-1 from the endoplasmic reticulum to synapses (PubMed:24094107). Interacts with usp-46; the interaction results in deubiquitination of glr-1 (PubMed:24356955).
messages: Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor (PubMed:7477293). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (PubMed:7477293). The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists (PubMed:7477293). May contribute to a sensory discrimination between mechanical and chemical stimuli (PubMed:7477293). Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response (PubMed:27223098). In AIB interneurons, promotes omega turns, a movement that frequently follows backwards locomotion or 'reversals' in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns (PubMed:27223098).
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Recycling endosome
messages: Synapse
messages: Ubiquitinated. Deubiquitinated by usp-46 which prevents its degradation.
messages: dendrite

6239:CELE F36H2.1
gene id: 6239:CELE_F36H2.1
uniprot id: G5EBH1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Cell membrane
messages: Plays a role in regulating membrane trafficking of cargo proteins during embryogenesis (PubMed:22100064, PubMed:30213940). Regulates snx-3 retromer-mediated endosomal sorting of mig-14, a transporter of Wnt egl-20 morphogen (PubMed:30213940). Together with mon-2 and pad-1, may participate in the formation of endosomal carriers that direct mig-14 trafficking back to Golgi, away from lysosomal degradation. Required for Wnt egl-20 gradient formation along the anteroposterior body axis and migration of QL neuroblast descendants toward the posterior part (PubMed:30213940). Maintains phosphatidylethanolamine (PE) asymmetry at the plasma membrane and prevents the budding of ectosome vesicles that affect intercellular communication and morphogenesis (PubMed:22100064).
messages: Produced by alternative promoter usage and alternative splicing.
messages: Produced by alternative splicing.

6239:CELE Y69A2AR.29
gene id: 6239:CELE_Y69A2AR.29
uniprot id: Q95XG7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator (By similarity). Regulates expression of various genes, including homeobox protein unc-42 and helix-loop-helix protein hlh-34 (PubMed:32273286). Required for embryonic viability, neuromuscular development, organization of the nerve ring and neuronal cell body location (PubMed:32273286). Regulates AIY neuron axon morphology and cell fate (PubMed:32273286). Plays a role in cell autonomously establishing a neuronal left-right asymmetry (PubMed:21041366). Involved in regulating glial specification (PubMed:32665354).
messages: Expressed in the early embryo in ABpra/p and MSpa/p cells, with weaker expression in ABar descendants (PubMed:32273286). Expressed left-right asymmetrically in the embryo, in the mother cell to the MI pharyngeal motorneuron but not the mother cell of the e3D epithelial cell (PubMed:21041366).
messages: Interacts with hlh-2; the interaction is direct.
messages: Nucleus

6239:CELE K07G5.5
gene id: 6239:CELE_K07G5.5
uniprot id: Q21304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE T20D4.2
gene id: 6239:CELE_T20D4.2
uniprot id: P91474
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T01D3.3
gene id: 6239:CELE_T01D3.3
uniprot id: P90956
uniprot id: Q7JL02
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

6239:CELE ZK1025.7
gene id: 6239:CELE_ZK1025.7
uniprot id: Q9XXM0
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE ZK643.2
gene id: 6239:CELE_ZK643.2
uniprot id: P30648
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Supplies the nucleotide substrate for thymidylate synthetase.

6239:CELE K06B9.5
gene id: 6239:CELE_K06B9.5
uniprot id: Q21263
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus
messages: Transcription factor (PubMed:17021039). Involved in negatively modulating apoptosis in germline and somatic cells, acting in partial redundancy with transcription factor egl-38/PAX5, probably by directly regulating transcription of apoptosis regulator ced-9 (PubMed:17021039). May bind to the DNA sequence motif 5'-GTAACG-3' in regulatory elements (PubMed:17021039).

6239:CELE K10B4.6
gene id: 6239:CELE_K10B4.6
uniprot id: P34888
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Cell membrane
messages: Cytoplasm
messages: Defective ALM, BDU and QR neuroblast migration and irregular HSN and CP axon growth and guidance (PubMed:16109397). Double knockout with cwn-2 results in ALM and CAN migration defects (PubMed:16109397). Double knockout with either cwn-2 or egl-20 results in HSN migration defects (PubMed:16516839). Triple knockout with cwn-2 and cfz-2 results in enhanced neuronal cell migratory defects (PubMed:16109397).
messages: Detected in all larval forms and adults, but is most abundant in the embryonic stage (PubMed:8510930). First expressed in the embryonic tail at the comma stage of embryogenesis (PubMed:16516839). In newly hatched larvae, it is expressed in four stripes of cells lining the dorsal and ventral posterior quadrants of the body (PubMed:16516839). Expression spreads anteriorly becoming restricted to the ventral side of the body as development progresses (PubMed:16516839).
messages: Expressed in intestine, some head neurons and ventral nerve cord and pharyngeal neurons (PubMed:19561603). Expressed in the tail and weakly expressed in the vulva and body wall muscles (PubMed:20711352). Expressed highly in posterior dorsal and ventral muscle cells (PubMed:22022276).
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1 (PubMed:17942487). Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). Also acts with the Wnt ligand egl-20 to direct HSN neuron migration (PubMed:16516839). Acts through the Wnt receptor cfz-2 to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with Wnt ligand cwn-2, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Probably by activating the Wnt/Frizzled pathway, may regulate vulva development (PubMed:17942487). May act redundantly with other Wnt ligands such as cwn-2 and mom-2 to control seam cell polarity (PubMed:22022276).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE T23D8.5
gene id: 6239:CELE_T23D8.5
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T23F2.3
gene id: 6239:CELE_T23F2.3
uniprot id: Q22700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Membrane

6239:CELE F32E10.3
gene id: 6239:CELE_F32E10.3
uniprot id: Q19970
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C37E2.4
gene id: 6239:CELE_C37E2.4
uniprot id: Q93352
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paired homeobox family.
messages: Expressed in ASE and AWC chemosensory neurons (PubMed:14536063, PubMed:15095973). Expressed left-right asymmetrically in the embryo, in the grandmother cell and the mother cell to the MI pharyngeal motorneuron but in neither analogous precursors of the e3D neuron (PubMed:21041366).
messages: Interacts with sox-2.
messages: Nucleus
messages: Probable transcription factor, acting as a progenitor identity factor regulating the development of lineally-related embryonic cells including glial, excretory and neuronal cells (PubMed:25738873, PubMed:21041366). Mediates chemosensory function of ASE and AWC neurons (PubMed:14536063, PubMed:15095973). In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons (PubMed:14536063, PubMed:15095973). Acts cell-autonomously to establish a neuronal left right asymmetry, possibly promoting asymmetric expression of the helix-loop-helix proteins ngn-1 and hlh-2 (PubMed:21041366). In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons (PubMed:26341465, PubMed:15095973). May regulate the expression of sox-2 in AWC olfactory neurons (PubMed:26341465).
messages: Up to the comma stage, expressed in six lineages that produce diverse cell types including pharyngeal cells, muscles, neurons and glia.

6239:CELE F32D8.5
gene id: 6239:CELE_F32D8.5
uniprot id: Q19966
uniprot id: Q9U3H0
names: Similarity
messages: Belongs to the TMEM70 family.

6239:CELE Y113G7A.6
gene id: 6239:CELE_Y113G7A.6
uniprot id: Q9U2Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expressed in the bilateral AFD neurons as well as in the nine pharyngeal marginal cells (PubMed:11580895). Expressed in amphid sheath AMsh and phasmid sheath PHsh glia (PubMed:21350017).
messages: Nucleus
messages: Probable transcription factor (PubMed:21350017, PubMed:25614239). Binds to a motif including the sequence 5'-TAA[TG]-3' in regulatory promoter elements (PubMed:21350017, PubMed:25614239). Modulates expression of its own, and of various other, genes in the AFD thermosensory neurons or AMsh amphid sheath glia, incuding the nuclear hormone receptor nhr-38, the LIM homeobox ceh-14, cyclic nucleotide-gated channel tax-2, receptor-type guanylyl cyclase gcy-8 and VEGF-related protein ver-1 (PubMed:11580895, PubMed:21350017, PubMed:25614239). Required for the development and cell fate of AFD neurons (PubMed:11580895, PubMed:21350017, PubMed:22298710). In concert with ceh-14, perhaps as components in a complex, specifies identity of AFD neurons, acting by synergistically regulating gcy-8, gcy-18 and other genes (PubMed:25614239). Involved in thermosensory behavior, thereby regulating entry and exit into the dauer larval stage of development (PubMed:11580895). Required in amphid sheath AMsh glia remodeling during entry into dauer stage, acting by positively regulating the expression of ver-1 in AMsh of amphid sensory neurons (PubMed:21350017, PubMed:22298710). May be essential for early development (PubMed:22298710).

6239:CELE C47F8.4
gene id: 6239:CELE_C47F8.4
uniprot id: O62113
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE Y54E10BR.4
gene id: 6239:CELE_Y54E10BR.4
uniprot id: Q9N3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

6239:CELE F35H10.10
gene id: 6239:CELE_F35H10.10
uniprot id: G5ECZ3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T12D8.4
gene id: 6239:CELE_T12D8.4
uniprot id: O45782
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the arrestin family.
messages: Expressed from the comma stage to adulthood in the nervous system, including sensory neurons and interneurons posterior to the nerve ring, dorsal and ventral nerve cords, tail ganglia and, CEP, HSN, ASK, ADL, ASH and ASJ neurons.
messages: Interacts with tax-6.
messages: Involved in several behavioral responses including chemotaxis towards lysine and adaptation to repeated osmotic stress. In addition, plays a role in resuming egg-laying and locomotion after starvation.
messages: Phosphorylated. Dephosphorylated by tax-6 in vitro.
messages: Viable. Shows defects in several behavioral responses, including abnormal avoidance response to the chemoattractant lysine and impaired adaptability induced by prior exposure to high concentration of fructose. Delay in egg-laying upon refeeding after starvation. Slight decrease in brood size.

6239:CELE C03A7.11
gene id: 6239:CELE_C03A7.11
uniprot id: O16506
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F59G1.5
gene id: 6239:CELE_F59G1.5
uniprot id: G5EC24
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm
messages: Expressed in embryonic cells, developing vulva, body wall muscles, head neurons and gonadal sheath cells.
messages: Involved in embryonic and larval development (PubMed:9472025, PubMed:20380830). Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP) (PubMed:9472025, PubMed:20380830). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15 (PubMed:16495308). Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1 (PubMed:11689700). Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23 (PubMed:9472025, PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100).
messages: RNAi-mediated knockdown causes an increase in ectopic formation of membrane extensions from body wall muscles and a reduction in life span caused by early stage mortality (PubMed:16495308, PubMed:16547100). Prevents constitutive dauer formation in a daf-2 e1370 mutant background (PubMed:16547100).

6239:CELE C09H5.7
gene id: 6239:CELE_C09H5.7
uniprot id: O16334
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE W02D7.7
gene id: 6239:CELE_W02D7.7
uniprot id: O17528
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: COPI-coated vesicle membrane
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: May have a role in the negative regulation of lin-12 and glp-1 transport to the cell surface (PubMed:10366590). May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles (PubMed:10366590). Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction (PubMed:27528192).

6239:CELE F09B12.5
gene id: 6239:CELE_F09B12.5
uniprot id: G5EBV9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T19A6.1
gene id: 6239:CELE_T19A6.1
uniprot id: G5EBW4
uniprot id: G5EDW0
uniprot id: G5EE99
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47D7A.16
gene id: 6239:CELE_Y47D7A.16
uniprot id: Q3LFN0
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activity is strongly inhibited by riboflavin analogs, such as lumiflavin and lumichrome.
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Down-regulated by high levels of riboflavin.
messages: Expressed in intestine.
messages: Highly expressed at L1 larval stage and to a lesser extent in adults.
messages: RNAi-mediated knockdown causes a severe reduction in the number of laid eggs; the few laid eggs fail to hatch.
messages: Riboflavin transporter. Riboflavin transport is Na(+)-independent but pH-sensitive.

6239:CELE F52F10.2
gene id: 6239:CELE_F52F10.2
uniprot id: Q9UAR0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T12D8.8
gene id: 6239:CELE_T12D8.8
uniprot id: G5EE04
names: Similarity
messages: Belongs to the FAM10 family.

6239:CELE Y105E8B.9
gene id: 6239:CELE_Y105E8B.9
uniprot id: Q95Q32
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Plays an important role in the degradation of dermatan and keratan sulfates.

6239:CELE F55A12.7
gene id: 6239:CELE_F55A12.7
uniprot id: O01755
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

6239:CELE F31F4.7
gene id: 6239:CELE_F31F4.7
uniprot id: O17123
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H38K22.3
gene id: 6239:CELE_H38K22.3
uniprot id: Q9XXA7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: Heme-binding protein.
messages: Secreted
messages: The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 136 and 169.

6239:CELE Y106G6H.3
gene id: 6239:CELE_Y106G6H.3
uniprot id: Q9XWS4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

6239:CELE F46F3.2
gene id: 6239:CELE_F46F3.2
uniprot id: P90876
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F46B3.4
gene id: 6239:CELE_F46B3.4
uniprot id: E1B6V6
uniprot id: Q9XV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE W01A8.4
gene id: 6239:CELE_W01A8.4
uniprot id: Q23098
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.

6239:CELE W07G4.4
gene id: 6239:CELE_W07G4.4
uniprot id: Q27245
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M17 family.
messages: Binds 2 Zn(2+) ions per subunit.

6239:CELE T28B4.3
gene id: 6239:CELE_T28B4.3
uniprot id: O17345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F46F6.2
gene id: 6239:CELE_F46F6.2
uniprot id: G5EFX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Nucleus

6239:CELE T09A5.11
gene id: 6239:CELE_T09A5.11
uniprot id: P45971
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal. Embryogenesis proceeds more slowly and embryos are osmo-sensitive.
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).

6239:CELE B0035.18
gene id: 6239:CELE_B0035.18
uniprot id: Q52GY9
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6c family.

6239:CELE C09G9.6
gene id: 6239:CELE_C09G9.6
uniprot id: G5EC86
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Exclusively expressed in the hermaphrodite gonad (PubMed:11702779, PubMed:12296824, PubMed:16611242). Expressed prior to oocyte division (PubMed:11702779). Widely distributed throughout gonadal oocytes from the mitotic stage to the developing diakinesis stage (PubMed:12296824). Expressed in sperm (PubMed:25261697).
messages: Expressed in newly fertilized embryos, but is rapidly degraded after initiation of the first mitotic division (PubMed:12781695, PubMed:16611242, PubMed:18417623). Highly expressed in one-cell embryos (PubMed:18854162). Expressed in P-granules in blastula-stage embryos (PubMed:16611242). Weak, if any, expression during larval stages (PubMed:11702779).
messages: Interacts with taf-4 (via C-terminus) (PubMed:18854162). Interacts with ifet-1 (PubMed:19786575). Component of a ribonucleoprotein particle complex that interacts with cgh-1 and car-1 in an RNA-dependent manner (PubMed:25261697). Association with many proteins is dependent on the presence of RNA (PubMed:25261697).
messages: No visible phenotype (PubMed:12296824, PubMed:12781695). Double knockout with oma-2 results in sterility due to an oocyte maturation defect (PubMed:11702779). The oocyte maturation defect is due to a meiotic defect in oocytes in which the maturation process is initiated, but there is no progression beyond the prophase stage of meiosis and therefore the cell division process is not completed (PubMed:11702779). Animals also have a larger number of oocytes which are larger in size, but the oocytes cannot be fertilized and accumulate within the gonad (PubMed:11702779). Double RNAi-mediated knockdown with oma-2 in embryos results in more widely distributed P-granules compared to wild-type embryos, and an irregular distribution of germline proteins including pgl-1, mex-1 and pie-1 (PubMed:16611242). Double RNAi-mediated knockdown with oma-2 in larva at the L4 stage of development results in 93% embryonic lethality following the first mitotic cleavage in offspring (PubMed:16611242). Double RNAi-mediated knockdown with oma-2 in adults results in a 60% reduction in number of eggs laid (PubMed:12296824). These animals also have an expanded proximal gonad arm which contains larger number of proximal oocytes which in turn contain a larger number of germinal vesicles and higher expression of maternal mRNAs including nos-2 (PubMed:12296824, PubMed:18417623). Furthermore, after the diakinesis stage following meiosis I, the germinal vesicles have dispersed chromosomes and an abnormal distribution of P-granules (PubMed:12296824). Embryos also display cell division (PubMed:19786575, PubMed:20826530). In addition, there is increased expression of target transcripts such as taf-4 and mei-1 which also exhibit an altered localization in oocytes and embryos (PubMed:18854162, PubMed:19786575, PubMed:25261697). Reduced expression of the maternal transcriptional repressor protein pie-1 (PubMed:20826530). Double RNAi-mediated knockdown with moe-3 results in a 20% reduction in number of eggs l…
messages: Nucleus
messages: Phosphorylation by mbk-2 and by gsk-3 are required for its rapid degradation following meiosis II.
messages: Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos (PubMed:18854162, PubMed:18417623, PubMed:19786575, PubMed:20826530, PubMed:24014033). Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes (PubMed:25261697). Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development (PubMed:11702779, PubMed:12296824, PubMed:12781695, PubMed:16289132, PubMed:16611242, PubMed:19786575, PubMed:20826530, PubMed:25261697). Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif-1 to negatively regulate their translation (PubMed:19786575, PubMed:20826530). By suppressing the translation of the E3 ligase zif-1, may in turn play a role in the stabilization of zif-1 targets such as the maternal transcriptional repressor protein pie-1 (PubMed:16343905, PubMed:20826530). Following fertilization, sequesters the transcription initiation factor, taf-4, in the cytoplasm, which prevents its nuclear localization and thus allows for transcriptional suppression in early embryos, but not in oocytes (PubMed:18854162). Also, together with oma-2, is involved in P-granule distribution during embryonic development (PubMed:16611242).

6239:CELE ZK836.2
gene id: 6239:CELE_ZK836.2
uniprot id: F5GUD7
uniprot id: Q23629
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: Mitochondrion
messages: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

6239:CELE F15D4.3
gene id: 6239:CELE_F15D4.3
uniprot id: Q93511
names: Function
names: Similarity
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

6239:CELE Y82E9BR.3
gene id: 6239:CELE_Y82E9BR.3
uniprot id: Q9BKS0
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 76% embryonic lethal, 24% larval arrest.
messages: Belongs to the ATPase C chain family.
messages: Derived from a bicistronic mRNA produced by trans-splicing that also produces excitatory amino acid transporter (glt-1).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Forms an homomeric c-ring of several subunits which is part of the complex rotary complex (Probable).
messages: Mitochondrion membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Trimethylated by ATPSCKMT at Lys-84. Methylation may be required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.

6239:CELE T05D4.1
gene id: 6239:CELE_T05D4.1
uniprot id: P54216
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: All stages of development.
messages: Belongs to the class I fructose-bisphosphate aldolase family.
messages: May be involved in the metabolism of fructose-bisphosphate (beta-D-fructose 1,6-bisphosphate) and of fructose 1-phosphate.
messages: Ubiquitous.

6239:CELE F58E6.13
gene id: 6239:CELE_F58E6.13
uniprot id: A0A061ACS5
uniprot id: H2FLH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T21C9.1
gene id: 6239:CELE_T21C9.1
uniprot id: Q22638
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Has been shown to interact (via PDZ domain) with atad-3 (via C-terminus) (PubMed:22245785). The physiological significance of this interaction is uncertain; the atad-3 C-terminus is expected to be within the mitochondrial matrix.
messages: Membrane
messages: Plays a role in the regulation of lifespan in a partially daf-16-mediated manner, and may be involved in regulating the levels of reactive oxygen species production in response to heat stress.
messages: RNAi-mediated knockdown in young adults results in an increased adult lifespan. At 37 degrees Celsius, levels of reactive oxygen species are reduced compared to wild-type animals. Double knockout with atad-3 RNAi results in an enhanced increase in adult lifespan as compared to the single mutants and wild-type animals.

6239:CELE C53B7.1
gene id: 6239:CELE_C53B7.1
uniprot id: Q18806
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling.
messages: Expressed in the cholinergic motor neurons AS, VA and DA in the ventral nerve cord and in the mechanosensory ALM neurons in the midbody.
messages: RNAi-mediated knockdown results in hypersensitivity to the acetylcholinesterase inhibitor aldicarb, indicating increased cholinergic transmission in mutant animals.
messages: Synapse
messages: axon

6239:CELE B0035.5
gene id: 6239:CELE_B0035.5
uniprot id: Q27464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
messages: cytosol

6239:CELE K03B4.3
gene id: 6239:CELE_K03B4.3
uniprot id: Q21172
uniprot id: Q95ZS0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF10 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed from the 4-cell stage through late gastrulation (at protein level) (PubMed:11566890). May be maternally expressed (PubMed:11566890).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced slightly in embryos (PubMed:11566890). Abolishes expression of taf-9, perhaps as a result of altered protein stability (PubMed:11566890). Reduces expression of a range of genes, including let-858, rps-5, hsp16.2, and pes-10, but has little or no effect on expression of cki-2 and sur-5 (PubMed:11566890).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-10 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex (PubMed:11566890).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.
messages: Throughout PMID:11566890, the gene name taf-11 is used instead of taf-10, based on an earlier nomenclature; readers should be aware to avoid confusion.

6239:CELE C42C1.15
gene id: 6239:CELE_C42C1.15
uniprot id: A3QMC6
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in the germline only.
messages: Expressed throughout development (at protein level) (PubMed:22269071). Highly expressed in embryos and L1 stage larvae (at protein level) (PubMed:22269071).
messages: No visible phenotype, with no change in growth rate at 20 or 26 degrees Celsius, general morphology or lifespan compared to wild-type (PubMed:22269071). Does not affect brood size, embryonic development or defecation rates of itr-1 (sa73) mutants (PubMed:22269071). No change in development or survival compared to wild-type animals following exposure to ER stress inducing agents such as tunicamycin and dithiothreitol (PubMed:22269071).
messages: Seems to form a multimeric complex.
messages: Unlike mammalian homologs, does not play an essential role in the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-triphosphate receptors (IP3Rs).

6239:CELE F53G12.3
gene id: 6239:CELE_F53G12.3
uniprot id: O01795
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Membrane

6239:CELE F19C7.4
gene id: 6239:CELE_F19C7.4
uniprot id: Q19590
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE ZK84.7
gene id: 6239:CELE_ZK84.7
uniprot id: Q7JPJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F13E6.1
gene id: 6239:CELE_F13E6.1
uniprot id: P55326
names: Similarity
messages: Belongs to the TPD52 family.

6239:CELE Y116A8C.34
gene id: 6239:CELE_Y116A8C.34
uniprot id: D3NQB1
uniprot id: Q9U2S6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE C50E10.8
gene id: 6239:CELE_C50E10.8
uniprot id: A3QMA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F54B11.3
gene id: 6239:CELE_F54B11.3
uniprot id: Q20745
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the unc-83-unc-84 LINC complex which contains at least unc-83 and unc-84 (PubMed:11748140, PubMed:16481402). Within the unc-83-unc-84 LINC complex interacts (via C-terminus) with unc-83; the interaction is probably required to recruit unc-83 to the nuclear membrane (PubMed:11748140, PubMed:16481402). Most likely interacts with anc-1; the interaction is probably required to recruit anc-1 to the nuclear envelope (PubMed:12169658). Interacts (via C-terminus) with zyg-12 (via C-terminus); the interaction is direct (PubMed:27956467). May interact with lmn-1; this interaction may be required to complete the connection between the nuclear lamina and the cytoskeleton (PubMed:25057012).
messages: Expressed in all cells of embryos from the 26-cell stage (PubMed:10375507, PubMed:11907270). Then, it is ubiquitously expressed throughout the development (PubMed:10375507, PubMed:11907270). Not expressed between fertilization and the 26-cell stage (PubMed:11907270).
messages: Expressed in all somatic cells (PubMed:11907270, PubMed:27956467). Not expressed in germ cells in the mitotic and transition zones of the gonad (PubMed:11907270). One study shows expression at the beginning of the late pachytene stage in the proximal gonad, but there is no expression in the male germline, suggesting expression is specific to oogenesis in hermaphrodites (PubMed:27956467).
messages: Induced by DNA-damage.
messages: Involved in nuclear migration and anchoring in hypodermal precursor cells (PubMed:10375507, PubMed:11748140, PubMed:12169658, PubMed:11907270, PubMed:16481402, PubMed:20921138, PubMed:21411627, PubMed:23150597, PubMed:25023515, PubMed:25057012). Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton (PubMed:12169658). Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules (PubMed:11748140, PubMed:16481402). Its role in nuclear migration may be in association with lamin, lmn-1 (PubMed:25057012). Regulates nuclear migrations in one-cell embryos, controlling the posterior migration of the male pronucleus following fertilization (PubMed:21798253). Not required for centrosome attachment to the nucleus (PubMed:10375507, PubMed:11907270). Plays a role in the maintenance of the nuclear envelope architecture in body wall muscle cells (PubMed:25023515). May be involved in DNA damage repair through an association with zyg-12 (PubMed:27956467). Potentially has roles in homologous recombination, double strand break repair and meiotic recombination (PubMed:27956467). Specifically, may in part inhibit non-homologous end joining repair, most likely through recruiting fan-1 to the nucleoplasm, to facilitate the repair of DNA cross-links (PubMed:27956467).
messages: Nucleus inner membrane
messages: The SUN domain probably plays a role in the nuclear anchoring and/or migration. Required for the localization of unc-83 and anc-1 at the nuclear membrane.
messages: cytoskeleton

6239:CELE F36F12.2
gene id: 6239:CELE_F36F12.2
uniprot id: O76399
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE K02D10.1
gene id: 6239:CELE_K02D10.1
uniprot id: P34492
names: Similarity
messages: Belongs to the NipSnap family.

6239:CELE K04H4.6
gene id: 6239:CELE_K04H4.6
uniprot id: P34508
names: Function
names: Similarity
messages: Belongs to the DNase II family.
messages: Involved in the degradation of chromosomal DNA. Contributes to cell killing.

6239:CELE C25E10.2
gene id: 6239:CELE_C25E10.2
uniprot id: Q27471
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE Y53C10A.5
gene id: 6239:CELE_Y53C10A.5
uniprot id: Q9XW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

6239:CELE ZK849.5
gene id: 6239:CELE_ZK849.5
uniprot id: O18304
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE Y110A2AL.12
gene id: 6239:CELE_Y110A2AL.12
uniprot id: D6RYD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

6239:CELE Y53F4B.19
gene id: 6239:CELE_Y53F4B.19
uniprot id: Q9NAA1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C18B2.2
gene id: 6239:CELE_C18B2.2
uniprot id: Q18078
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To C.elegans C41C4.1 and C18B2.1.

6239:CELE F10G2.1
gene id: 6239:CELE_F10G2.1
uniprot id: Q22957
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0376 family.
messages: Membrane

6239:CELE F59A6.6
gene id: 6239:CELE_F59A6.6
uniprot id: Q86MG7
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

6239:CELE K08B12.5
gene id: 6239:CELE_K08B12.5
uniprot id: A0A0K3AUZ7
uniprot id: O01583
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: Expressed in embryonic and L4 larval seam cells and in embryonic dorsal and ventral epidermal cells. Also expressed in the pharynx throughout development and in sublateral nerve cords in the L4 larva.
messages: Normal adult development, but progeny arrest at either the L1 stage or during embryogenesis (PubMed:19675126). RNAi-mediated knockdown causes excretory canal truncation, abnormal lumen and cyst formation. In addition, causes a reduced distribution of Golgi and ER components along the excretory canal length and a decrease in cdc-42 activation (PubMed:25743393).
messages: Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation (PubMed:19675126). Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation (PubMed:25743393).

6239:CELE Y38F2AR.10
gene id: 6239:CELE_Y38F2AR.10
uniprot id: Q95XR9
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE W06B4.2
gene id: 6239:CELE_W06B4.2
uniprot id: Q23195
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

6239:CELE ZK970.2
gene id: 6239:CELE_ZK970.2
uniprot id: Q27539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S14 family.
messages: Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis. Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
messages: Expressed in the intestine.
messages: Mitochondrion matrix
messages: Tetradecamer that assembles into a two heptameric rings with a central cavity.

6239:CELE C17C3.1
gene id: 6239:CELE_C17C3.1
uniprot id: B0M0L9
uniprot id: H2KYT6
uniprot id: Q9BIA9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE Y39H10A.3
gene id: 6239:CELE_Y39H10A.3
uniprot id: Q965W9
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 346 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Expressed in the intestine and in head and tail neurons including CAN neuron at L1 stage larva. Expressed in the postdeirid neuron, in the developing vulva and in rectal epithelial cells at L2 stage larva. Expressed in lateral hypodermal (seam) cells and the hypodermal syncytium (hyp7) at L3 stage larva.
messages: Heterodimer with lipid phosphatase mtm-6.
messages: May act as a regulatory subunit for mtm-6. In association with phosphatase mtm-6, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels (PubMed:14565969). Regulates fluid phase endocytosis in coelomocytes (PubMed:14565969). Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval development probably by controlling Wnt ligand secretion through the regulation of sorting receptor mig-14 trafficking (PubMed:21076391). Involved in the formation of correct synapse number in DA9 motor neurons (PubMed:25479419).
messages: Membrane

6239:CELE E03H4.6
gene id: 6239:CELE_E03H4.6
uniprot id: O17748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T05H10.5
gene id: 6239:CELE_T05H10.5
uniprot id: Q09349
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as an E4 ubiquitin ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (PubMed:27669035). The elongation of preexisting ubiquitin chains preferentially targets ubiquitin 'Lys-29' and 'Lys-48' residues (PubMed:27669035). Also functions as an E3 ligase in conjunction with specific E1 and E2 ligases (PubMed:15294159, PubMed:27669035, PubMed:29396393). Probably by regulating protein ubiquitination at DNA damage repair sites, coordinates DNA double-strand-break repair and apoptosis in the germline (PubMed:27669035). Required for germline apoptosis in response to DNA damage downstream of cep-1 (PubMed:27669035). Involved in the resolution of DNA-repair sites by promoting the release of rad-51 from DNA damage foci (PubMed:27669035). In association with protein-ligase chn-1, acts as an E3/E4 ligase to poly-ubiquitinate lysine residues in the UCS domain of myosin chaperone unc-45 (PubMed:15294159, PubMed:29396393). By targeting myosin chaperone unc-45 for proteasomal degradation, regulates myosin assembly in body wall muscles in association with cdc-48.1 and chn-1 (PubMed:15294159, PubMed:17369820). However, in a contrasting study, acts as an E3 ligase, independently of chn-1, to poly-ubiquitinate unc-45 without promoting unc-45 proteasomal degradation (PubMed:29396393). Instead, uses unc-45 as an adapter protein to recruit and poly-ubiquitinate unfolded myosin heavy chain B unc-54 (PubMed:29396393).
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: Expressed in the germline (at protein level).
messages: Expressed in young adults but not in larvae (PubMed:17369820). Expressed in pharyngeal muscles and in body wall muscles in L2 and L4 larvae, respectively (PubMed:15294159).
messages: Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1; within the complex interacts with atx-3 and cdc-48.1 (via DDDLYN motif) (PubMed:21317884, PubMed:27669035). Forms a complex composed of cdc-48.1, myosin chaperone unc-45, ubiquitin-protein ligases ufd-2 and chn-1; the complex targets myosin chaperone unc-45 for proteasomal degradation; within the complex interacts with cdc-48.1 (via DDDLYN motif), chn-1 and unc-45 (PubMed:17369820, PubMed:15294159, PubMed:27669035). Forms a complex composed of unc-45 and myosin heavy chain B unc-54; the complex targets unfolded unc-54 for proteasomal degradation; within the complex interacts with unc-45 (via TPR domain) and unc-54 (PubMed:29396393). Interacts with cdc-48.2 (via DDDLYN motif) (PubMed:21317884, PubMed:17369820).
messages: Nucleus membrane
messages: Number of germline apoptotic corpses is decreased in response to ionizing radiation-mediated DNA damage but not following UV-induced DNA damage (PubMed:27669035). Delay in the dissociation of rad-51 from DNA damage foci (PubMed:27669035). In a hecd-1 (tm2371) mutant background, the decrease in the number of germline apoptotic corpses is more severe (PubMed:27669035). In an atx-3 (gk193) mutant background, prevents the increase in the number of germline apoptotic corpses (PubMed:27669035). RNAi-mediated knockdown in an unc-45 (m94) mutant background restores motility (PubMed:17369820).
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: The role of chn-1 in ufd-2-mediated unc-45 ubiquitination is controversial. While two studies showed that unc-45 ubiquitination by ufd-2 requires ubiquitin-protein ligase chn-1, one study showed that ufd-2 ubiquitinates unc-45 independently of chn-1.
messages: nucleolus

6239:CELE Y110A7A.5
gene id: 6239:CELE_Y110A7A.5
uniprot id: Q9N589
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Cytoplasmic granule membrane
messages: Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles (PubMed:19816564, PubMed:21490059). Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex (PubMed:19816564, PubMed:21490059). In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane (PubMed:21490059). Essential for embryonic and larval development (PubMed:19816564). May promote migration of distal tip cells (PubMed:19816564).
messages: Expressed in embryo, larva and in adults (PubMed:19816564, PubMed:21490059). Expressed in a few head and tail neurons (PubMed:12788949). Expressed in hypodermis, body wall and pharyngeal muscles, sheath cells, vulva, distal tip cells and coelomocytes (PubMed:19816564, PubMed:21490059).
messages: RNAi-mediated knockdown causes an increase in PI3P levels in intracellular vesicles. Also causes an increase in germline cell corpse engulfment, although corpses fail to be cleared. RNAi-mediated knockdown in ced-1, ced-6, ced-2, ced-10 or ced-7 mutant background partially restores cell corpses engulfment.
messages: The GRAM domain is required for localization to the plasma membrane.
messages: The myotubularin phosphatase domain is required for localization to the plasma membrane.
messages: phagocytic cup

6239:CELE B0272.3
gene id: 6239:CELE_B0272.3
uniprot id: P41938
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: Homodimer.
messages: Mitochondrion matrix

6239:CELE T01H3.1
gene id: 6239:CELE_T01H3.1
uniprot id: G5EDB8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Expressed in the H-shaped excretory cell, rectum, and a pair of cells posterior to the anus.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). The V-ATPase is required for the function of the excretory canal (PubMed:16785323). Involved in receptor-mediated endocytosis (PubMed:16785323).
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:16785323). Causes defects in alae formation in the few surviving larvae and impairs yolk uptake by the oocytes from the pseudoceolomic cavities (PubMed:16785323). Causes an increase in the section of the excretory canal, which often has multiple lumens and abnormal whorls (PubMed:16785323).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE C10C6.2
gene id: 6239:CELE_C10C6.2
uniprot id: P90745
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE K07A12.1
gene id: 6239:CELE_K07A12.1
uniprot id: P90919
names: Similarity
messages: Belongs to the TCF25 family.

6239:CELE C10G8.4
gene id: 6239:CELE_C10G8.4
uniprot id: Q94162
names: Subcellular Location Annotation
messages: Secreted

6239:CELE VC5.6
gene id: 6239:CELE_VC5.6
uniprot id: Q2V068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C13D9.9
gene id: 6239:CELE_C13D9.9
uniprot id: O16243
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R07B1.12
gene id: 6239:CELE_R07B1.12
uniprot id: G5EBF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

6239:CELE Y54G2A.2
gene id: 6239:CELE_Y54G2A.2
uniprot id: Q688Z6
uniprot id: Q9BMU4
uniprot id: U4PLG5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

6239:CELE F31E3.1
gene id: 6239:CELE_F31E3.1
uniprot id: P41779
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TALE/PBX homeobox family.
messages: Expressed in QR and QL neuroblasts, P and V cells and all their respective descendents, M cells, BDU interneurons, ALM and HSM neurons, body wall muscles, I4, all ventral cord neurons and in a few unidentified neurons in the head behind the posterior bulb of the pharynx during the L1 stage of larval development (PubMed:15750187). Expressed in V cell descendents from the larval stage of development to adulthood (PubMed:15750187). Expressed in the midbody dopaminergic PDE neurons throughout life (PubMed:23788625).
messages: Expressed in head dopaminergic neurons.
messages: Interacts with Meis protein psa-3 (PubMed:16824957). Interacts with homeobox protein nob-1 (PubMed:16824957).
messages: Nucleus
messages: RNAi-mediated knockdown results in egg laying defects, abnormal migration of QR neuroblast lineage cells and vulval protrusions due to ectopic induction and defective morphogenesis of vulval precursors cells (PubMed:15750187). RNAi-mediated knockdown results in the absence of the transcription factor, mls-2, in the M lineage (PubMed:18316179).
messages: Transcription factor that binds to the 5'-TGATNNAT(G/T)(G/A)-3' PBC/Hox lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage) (PubMed:21307099). Required for the M lineage-specific expression of the transcription factor, mls-2 (PubMed:18316179). Required for asymmetric division of the T hypodermal cell, probably acting via the regulation of asymmetric expression of Meis protein psa-3 in concert with homeobox protein nob-1 and the Wnt-MAPK pathway (PubMed:16824957). Has a role in the mig-13 pathway to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis and the anterior migration of BDU interneurons (PubMed:15750187). Also required for normal vulval formation (PubMed:15750187). Plays a role in regulating gene expression in dopaminergic neurons, acting in midbody PDE neurons, and acting redundantly with ceh-40 in head neurons (PubMed:23788625). May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-43 and ceh-40 (PubMed:23788625).

6239:CELE F46B6.3
gene id: 6239:CELE_F46B6.3
uniprot id: Q20445
uniprot id: Q8WQF3
names: Similarity
messages: Belongs to the RENT3 family.
messages: Belongs to the UPF0587 family.

6239:CELE T18D3.4
gene id: 6239:CELE_T18D3.4
uniprot id: P12845
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Found exclusively in the pharyngeal muscle.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: Muscle contraction.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with itr-1.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: There are four different myosin heavy chains in C.elegans.
messages: myofibril

6239:CELE Y97E10AM.1
gene id: 6239:CELE_Y97E10AM.1
uniprot id: Q9N2V1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K04G11.4
gene id: 6239:CELE_K04G11.4
uniprot id: Q93847
names: Disruption Phenotype
names: Function
messages: No obvious phenotype at 20 degrees Celsius or 25 degrees Celsius. At 20 and 25 degrees Celsius, double knockdown mutants with wdr-5.1 have increased fog-3 expression. At 25 degrees Celsius, these mutants have increased fog-1 expression, reduced brood size accompanied by 42% embryonic lethality with 100% of the surviving progeny being sterile. Surviving progeny display defective spermatogenesis to oogenesis transition with 88% of the gonads only containing sperm. The remaining germ cells in the gonads switch to oogenesis, but the oocytes display either an endoreplication or endomitotic phenotype. Germ cells also have increased expression of the sex determining factor tra-1 in the cytoplasm and as a result there is reduced binding of tra-1 to the fog-3 promoter. No detectable defects in histone H3 'Lys-4' di- or tri-methylation in embryos or adults germ cells at 20 or 25 degrees Celsius.
messages: Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'.

6239:CELE F14E5.2
gene id: 6239:CELE_F14E5.2
uniprot id: Q19459
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK1058.5
gene id: 6239:CELE_ZK1058.5
uniprot id: Q23383
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

6239:CELE C18G1.7
gene id: 6239:CELE_C18G1.7
uniprot id: O61918
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F09A5.1
gene id: 6239:CELE_F09A5.1
uniprot id: Q19235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6239:CELE T07A5.3
gene id: 6239:CELE_T07A5.3
uniprot id: Q10046
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
messages: Membrane

6239:CELE Y55F3AR.2
gene id: 6239:CELE_Y55F3AR.2
uniprot id: Q9N357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

6239:CELE T07A9.8
gene id: 6239:CELE_T07A9.8
uniprot id: O44410
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: Probable methyltransferase required to silence rDNA.
messages: nucleolus

6239:CELE K08E3.2
gene id: 6239:CELE_K08E3.2
uniprot id: Q9XUT1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F52C12.1
gene id: 6239:CELE_F52C12.1
uniprot id: Q9TXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity).
messages: Nucleus

6239:CELE F08A8.2
gene id: 6239:CELE_F08A8.2
uniprot id: O62137
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by ATP (PubMed:27551084). ATP binding leads to a conformational change that promotes FAD cofactor binding and enzyme activity (PubMed:27551084). ATP binding likely occurs during acox-1.2 folding and/or dimer formation (PubMed:27551084). The preference for processing substrates with shorter fatty acid chains is likely due to the closed conformation of the active site (PubMed:27551084).
messages: Belongs to the acyl-CoA oxidase family.
messages: Homodimer (Probable) (PubMed:27551084). Forms a heterodimer with acox-1.1 (PubMed:25775534).
messages: Induced by high temperatures (25 degrees Celsius) (PubMed:25775534). Down-regulated in dauer conditions (PubMed:25775534).
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:25775534, PubMed:27551084). Specifically, shortens ascarosides with 5-carbon omega side chain (asc-omega-C5) (PubMed:25775534, PubMed:27551084). Does not shorten indol-3-carbonyl(IC)-ascaroside with 7-carbon or 9-carbon side chains (PubMed:29863473). Does not catalyze the desaturation of fatty acids or hydroxylated fatty acids (PubMed:25775534, PubMed:27551084).
messages: Peroxisome

6239:CELE T14B1.2
gene id: 6239:CELE_T14B1.2
uniprot id: G5ECD9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the intestinal muscle, anal depressor, AVL and DVB GABAergic neurons, enteric muscles, the nerve ring, the ventral nerve cord and head mesodermal cells.
messages: G-protein coupled receptor for the nlp-40 neuropeptide (PubMed:23583549). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23583549). Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds (PubMed:18852466, PubMed:23583549). Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation (PubMed:18852466, PubMed:23583549). Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine (PubMed:25849533).
messages: RNAi-mediated knockdown results in a mild defecation defect.
messages: cilium

6239:CELE Y71G12B.20
gene id: 6239:CELE_Y71G12B.20
uniprot id: Q95XP4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the semaphorin family.
messages: Interacts with plx-2.
messages: Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis (PubMed:10648234, PubMed:12403719, PubMed:17761667). In early embryonic development, required for proper ventral closure of the epidermis (PubMed:12403719). During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays (PubMed:12679110). Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129 (PubMed:15030761). Involved in follower axon guidance (PubMed:25358863, PubMed:28846083). In particular, it is required for the guidance of axons from neurons, including SubL neurons and AIY interneurons, into the nerve ring (PubMed:28846083). Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons (PubMed:25358863).
messages: Required for the guidance of axons from neurons, including AIY interneurons, into the nerve ring.
messages: Secreted
messages: Ubiquitously expressed.
messages: Worms have defects both in early embryonic morphogenesis and in postembryonic male tail morphogenesis.

6239:CELE F18F11.4
gene id: 6239:CELE_F18F11.4
uniprot id: P91263
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE T07A5.6
gene id: 6239:CELE_T07A5.6
uniprot id: A7LPF8
uniprot id: G5EDQ5
uniprot id: Q9U377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

6239:CELE C56C10.13
gene id: 6239:CELE_C56C10.13
uniprot id: Q95QQ1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R07E5.13
gene id: 6239:CELE_R07E5.13
uniprot id: Q21828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: May mediate the uptake of pyruvate into mitochondria.
messages: Mitochondrion inner membrane

6239:CELE C49D10.10
gene id: 6239:CELE_C49D10.10
uniprot id: O16607
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE C31C9.2
gene id: 6239:CELE_C31C9.2
uniprot id: O17626
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

6239:CELE F15E6.1
gene id: 6239:CELE_F15E6.1
uniprot id: O44498
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Contrary to other SET-domain containing methyltransferases, set-9 does not have the residues usually involved in cofactor binding: instead of the highly conserved XGXG, Y and NH motifs, set-9 displays AVEA (Ala-940-Ala-943), V (Val-959) and F (Phe-1055) and RR (Arg-1016-Arg-1017) motifs.
messages: Histone methyltransferase (By similarity). Might play a role in transcriptional regulation (PubMed:29714684). Together with set-26, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion (PubMed:22212395, PubMed:29714684). Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline (PubMed:29714684).
messages: Nucleus
messages: Predominantly expressed in the germline (at protein level).
messages: Simultaneous RNAi-mediated knockdown of set-9 and set-26 results in extended lifespan.
messages: The PHD-type domain binds histone H3 when trimethylated at 'Lys-4' (H3K4me3) in combination with a nearby acetylation (K9ac, K14ac and/or K18ac), but not H3K4me3 alone.

6239:CELE F44C8.9
gene id: 6239:CELE_F44C8.9
uniprot id: H2L019
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F35C8.3
gene id: 6239:CELE_F35C8.3
uniprot id: G5EDT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Cytoplasm
messages: Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1 (PubMed:10393177, PubMed:15767565, PubMed:17894411). Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1 (PubMed:10393177, PubMed:11738026). Positively regulates lifespan (PubMed:15767565). Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1 (PubMed:15767565). Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and to arsenite (PubMed:18597494, PubMed:19497412).
messages: Expressed in most neurons, including nerve ring, head ganglions, dorsal and ventral nerve cords and tail ganglions.
messages: Interacts with unc-16.
messages: Perikaryon
messages: axon

6239:CELE C55B7.2
gene id: 6239:CELE_C55B7.2
uniprot id: Q9NDH7
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 18 family.
messages: Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides.
messages: Expressed in a complex subset of neurons in larvae and in the spermathecal and pharyngeal-intestinal valves and certain vulval cells of adults.
messages: Golgi apparatus membrane
messages: In embryos, expressed from the late comma stage.

6239:CELE T06D8.8
gene id: 6239:CELE_T06D8.8
uniprot id: Q22253
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S11 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

6239:CELE Y45G12C.9
gene id: 6239:CELE_Y45G12C.9
uniprot id: A0A0M7REE8
uniprot id: G5EG08
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y37E11AM.3
gene id: 6239:CELE_Y37E11AM.3
uniprot id: U4PBL3
uniprot id: U4PM16
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F31D5.3
gene id: 6239:CELE_F31D5.3
uniprot id: H2KYS8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basal cell membrane
messages: Belongs to the copine family.
messages: Embryos stop elongation at the 2-fold stage and have defects in the organization of the myofibril lattice. pat-3, deb-1, pat-4 and pat-6 are slightly mislocalized in the post 1.5-fold stage. At the 1.5-fold stage, unc-89 and myo-3 localization is normal. However, at the 1.75- and 2-fold stages, unc-89 and myo-3 are mislocalized into large foci within muscle cells.
messages: Expressed in body wall muscles (at protein level).
messages: Expressed in embryos and in adults.
messages: Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin-mediated attachment sites.
messages: M line
messages: May interact (via VWFA domain) with unc-89 (via Ig-like C2-type 1-3) and unc-96 (via C-terminus); cpna-1 binding sites for unc-89 and unc-96 are different. May interact with pat-6. May interact with lim-9 (via LIM domains) and with scpl-1 (via FCP1 homology domain).

6239:CELE Y53G8AR.8
gene id: 6239:CELE_Y53G8AR.8
uniprot id: Q9N3G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion

6239:CELE F56D1.4
gene id: 6239:CELE_F56D1.4
uniprot id: H2KZM6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
messages: Cell membrane
messages: Expressed in muscles, hypodermis and a subset of neurons (PubMed:9585503, PubMed:26968353). Expressed in the AVA neurons, with high expression in the anterior half of the preanal ganglion where AVA neurons contact the PHB neurons (PubMed:29742100).
messages: Mutants have a reduced size and a loss of both motility and fertility. In addition the pharynx and the intestine appear to float within the pseudocoelom resulting from the accumulation of fluid. The majority die during larval development with hypodermal ruptures. Simultaneous knockdown of clr-1 and egl-15 rescues the thin body morphology of egl-15 mutants.
messages: Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity (PubMed:9585503). Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle (PubMed:9585503). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles (PubMed:16495308). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870). Promotes the outgrowth of the quaternary dendritic branches of the PVD sensory neurons (PubMed:26968353). In parallel to the sax-7/mnr-1 pathway, also controls the extension of the PVD primary branches (PubMed:26968353). Acts in the netrin/DCC pathway to mediate the formation of synapses between the AVA interneurons and the PHB sensory neurons (PubMed:29742100). Also required for the formation of synapses between the AVA interneurons and the VA10 motor neurons (PubMed:29742100).
messages: Synapse
messages: The extracellular domain is required for the formation of synapses between the AVA interneurons and the PHB sensory neurons.
messages: Tyrosine-protein phosphatase 1 domain has enzymatic activity which is required for the negative regulation of egl-15 (PubMed:9585503). Tyrosine-protein phosphatase 1 domain is required for correct PVD dendrite formation (PubMed:26968353). The second tyrosine-protein phosphatase domain has no phosphatase activity and appears to be dispensable for clr-1 function (PubMed:9585503). Isoform c lacks both tyrosine-protein phosphatase domains and is likely to have no catalytic activity (PubMed:9585503).

6239:CELE M01G12.12
gene id: 6239:CELE_M01G12.12
uniprot id: G5EFA8
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE W09G12.4
gene id: 6239:CELE_W09G12.4
uniprot id: O45201
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate; phenotype exacerbated when combined with simultaneous RNAi-mediated knockdown of apx-1 and lag-2, and further worsened on lin-15 mutant background (PubMed:14960273). Severe vulval precursor cell (VPC) fate abnormalities, vulval defects and failure to up-regulate lip-1 expression, on an osm-11 mutant background (PubMed:18700817).
messages: May interact with lin-12/Notch receptor.
messages: Probable secreted Notch ligand involved in the mediation of Notch signaling (PubMed:14960273, PubMed:18700817). Involved in the lin-12/Notch pathway-mediated signaling of cell fate in vulval precursor cells (VPCs), acting redundantly with lag-2, apx-1 and osm-11 (PubMed:14960273, PubMed:18700817). May also be involved in glp-1/Notch signaling (PubMed:14960273).
messages: Secreted

6239:CELE F57F5.5
gene id: 6239:CELE_F57F5.5
uniprot id: H9G2Y7
uniprot id: P34885
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Attenuated response to nose touch stimulation. Defects in salt attraction. Disrupted chemotaxis. Hyperactivation of AFD thermosensory neurons but inactivation of the ASH neurons. Reduced dauer formation. Protection from hemiasterlin toxicity by carbonyl cyanide p-[trifluoromethoxy]-phenyl-hydrazone (FCCP) greatly reduced. Reduced neuropeptide secretion.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Expressed selectively in neurons that receive, transmit and process environmental signals.
messages: Membrane
messages: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neurons, olfactory perception in AWA and AWC neurons. Promotes dauer formation mediated by the insulin/IGF pathway. Required for resistance to antimitotic toxins.
messages: cytoskeleton

6239:CELE W02G9.2
gene id: 6239:CELE_W02G9.2
uniprot id: G5ED84
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the BCR(kel-8) E3 ubiquitin ligase complex, at least composed of cul-3, kel-8 and rbx-1. Interacts with rpy-1.
messages: Expressed in neurons.
messages: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1.
messages: Synapse

6239:CELE T06C12.10
gene id: 6239:CELE_T06C12.10
uniprot id: O18037
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide to produce glucosylceramides (GlcCer). GlcCer are known to contribute to the physical properties and physiological functions of membranes and may regulate signal transduction (PubMed:19240113, PubMed:21325339). Only branched-chain sphingoid bases like 15-methylhexadecasphing-4-enine are used for generating complex sphingolipids in Caenorhabditis elegans (PubMed:7651085). Together with cgt-3, plays a role in the trafficking of proteins such as mig-14 to the cell membrane in intestinal cells (PubMed:26115433).
messages: Expressed in excretory canals, pharyngeal intestinal valve, intestine and intestinal rectal valve.
messages: Knockdown of cgt-1 alone reduces brood size, while simultaneous knockdown of cgt-3 and cgt-1 results in a larval stage death (L1 lethal) phenotype (PubMed:19240113, PubMed:21325339). Double RNAi-mediated knockdown together with cgt-3 reduces the rate of development and restores the basolateral cell membrane localization of mig-14 in intestinal cells in a sgk-1 ok538 mutant background (PubMed:26115433).
messages: Membrane
messages: The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.

6239:CELE Y59A8B.21
gene id: 6239:CELE_Y59A8B.21
uniprot id: Q9GRY3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y105C5B.28
gene id: 6239:CELE_Y105C5B.28
uniprot id: H8ESF5
uniprot id: Q2HQL4
uniprot id: Q9U307
names: Similarity
messages: Belongs to the glutamine synthetase family.

6239:CELE F10D2.7
gene id: 6239:CELE_F10D2.7
uniprot id: O16916
names: Subcellular Location Annotation
messages: Membrane

6239:CELE PAR2.4
gene id: 6239:CELE_PAR2.4
uniprot id: P45895
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Expressed in distal tip cells of the growing gonad arms from L3 to the young adult stage (at protein level).
messages: Expressed in seam cells, the vulval epithelium and in oocytes (at protein level).
messages: Golgi stack membrane
messages: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin (PubMed:15485872). Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development (PubMed:15485872, PubMed:16982046). May have a specific role in unc-6/netrin-mediated dorsal guidance of gonadal distal tip cells (PubMed:16982046). Glycosyltransferase activity is weak (PubMed:15485872).
messages: Interacts with sqv-5.
messages: Viable but sterile, with reversion of cytokinesis during early embryogenesis.

6239:CELE C07A12.7
gene id: 6239:CELE_C07A12.7
uniprot id: H2KYH5
uniprot id: Q95QX5
names: Similarity
messages: Belongs to the TOM1 family.

6239:CELE Y67H2A.6
gene id: 6239:CELE_Y67H2A.6
uniprot id: Q95PZ0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although strongly related to metalloprotease proteins, it lacks the JAMM motif that probably constitutes the catalytic center. Its function as protease is therefore unsure.
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-2 and csn-4. Interacts with rbx-1.
messages: Cytoplasm
messages: Nucleus

6239:CELE C49H3.10
gene id: 6239:CELE_C49H3.10
uniprot id: Q9GYQ7
uniprot id: W6RQY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

6239:CELE F28C12.2
gene id: 6239:CELE_F28C12.2
uniprot id: O18689
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F28H7.9
gene id: 6239:CELE_F28H7.9
uniprot id: Q19897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE ZK1320.1
gene id: 6239:CELE_ZK1320.1
uniprot id: Q09652
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

6239:CELE Y47H9C.5
gene id: 6239:CELE_Y47H9C.5
uniprot id: Q9XWE1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T04A8.7
gene id: 6239:CELE_T04A8.7
uniprot id: Q22137
uniprot id: Q86G92
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

6239:CELE F26F4.10
gene id: 6239:CELE_F26F4.10
uniprot id: Q19825
uniprot id: Q65ZK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
messages: cytosol

6239:CELE F14B4.1
gene id: 6239:CELE_F14B4.1
uniprot id: G5EFK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE M02H5.7
gene id: 6239:CELE_M02H5.7
uniprot id: G5EDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C18C4.3
gene id: 6239:CELE_C18C4.3
uniprot id: Q18081
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDP-glycosyltransferase family.
messages: Interacts with cmd-1 in the presence of Ca(2+).
messages: Membrane

6239:CELE Y41D4B.12
gene id: 6239:CELE_Y41D4B.12
uniprot id: Q95Y12
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Chromosome
messages: Embryonic lethal.
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus
messages: Probable histone methyltransferase (By similarity). Required for embryonic development.

6239:CELE F53B2.6
gene id: 6239:CELE_F53B2.6
uniprot id: G5EEC5
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: First expressed at the onset of gastrulation, approximately 100 minutes after cleavage of the zygote (at protein level) (PubMed:8951066). Expressed in both Q.a and Q.p neuroblasts as well as in their neighboring cells (PubMed:23946438).
messages: Nucleus
messages: Probable transcription factor (PubMed:23946438). Required for asymmetric cell division in neuroblasts, perhaps acting by regulating spindle positioning and myosin polarization, and thus the position of the cleavage plane (PubMed:3200316, PubMed:18505863, PubMed:8951066, PubMed:26703426, PubMed:15979607, PubMed:23946438). Required to produce daughter cell size asymmetry in neuroblasts undergoing asymmetric cell division, usually giving rise to one precursor cell and one apoptotic cell (PubMed:29668718, PubMed:15979607, PubMed:23946438). Positively modulates expression of the serine/threonine kinase pig-1/MELK during asymmetric division of the Q.a neuroblast (PubMed:23946438). Plays a role in neural fate specification in several dopaminergic lineages, including the hermaphrodite-specific neuron (HSN)/phasmid neuron (PHB), acting in concert with the kinase, ham-1, and the T-box protein tbx-2 and the homeobox protein egl-5 (PubMed:3200316, PubMed:18505863, PubMed:8951066, PubMed:28659600, PubMed:23946438).
messages: cell cortex

6239:CELE Y37D8A.9
gene id: 6239:CELE_Y37D8A.9
uniprot id: A7DTF0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465). Interacts with cfp-1, a component of the SET2 complex (PubMed:31602465). Interacts with rfp-1 (PubMed:25564623).
messages: Expressed in embryos, L1 larvae and adult hermaphrodites and decreases drastically between the L2 and L4 larval stages (at protein level) (PubMed:12175490, PubMed:17215300). In late embryos and young larvae, expressed at higher levels in the two primordial germ cells (PGCs), Z2 and Z3, than in somatic blastomeres (PubMed:17215300, PubMed:30929290). Expressed at a relatively constant level throughout the distal end of the gonad at the L1 stage, with no decrease as cells enter into meiotic prophase (PubMed:25564623).
messages: Expressed in oocytes (at protein level) (PubMed:12175490). Expressed mainly in germ cells, but also at lower levels in several somatic cell types, including intestinal cells (PubMed:17215300).
messages: Maternal-effect lethality and sterility (PubMed:17215300). Primordial germ cells (PGCs) do not proliferate normally and death of germ cells may be as a result of necrosis or increased apoptosis (PubMed:17215300, PubMed:22212480). Increased proportion of oocytes with fragmented chromosomes as a result of irradiation (PubMed:22212480). Tumorous germline phenotype that is suppressed on a rfp-1;glp-1 double mutant background (PubMed:25564623). Germline progression from leptotene/zygotene to pachytene is defective (PubMed:22212480). Perinuclear anchoring of heterochromatin in intestinal or hypodermal cells is disrupted and exacerbated on a cec-4 mutant background, but is partially blocked by RNAi-mediated knockdown of cbp-1 or atf-8 (PubMed:31118512). RNAi-mediated knockdown causes defective homologous chromosome pairing, complete absence of the germline in almost all adult F1 progeny and slight underdevelopment of the somatic gonad (PubMed:12175490, PubMed:22172672). RNAi-mediated knockdown strongly blocks mitosis of PGCs at early larval stages, and the arrested PGCs may degenerate during late larval stages (PubMed:12175490). RNAi-mediated knockdown induces germ cells to undergo conversion into neuron-like cells (PubMed:30425042). RNAi-mediated knockdown causes a slight increase in levels of the constitutive heterochromatin mark, trimethylated histone H3 'Lys-9' (H3K9me3), and an increase of acetylated histone H3 'Lys-14' (H3K14ac) (PubMed:30425042). Simultaneous RNAi-mediated knockdown of mep-1 suppresses the ectopic expression of pgl-1 protein and the overexpression of pgl-1 mRNA in larvae (PubMed:17215300). RNAi-mediated knockdown induces germ cell apoptosis; however, on clk-2 or cep-1 mutant backgrounds apoptosis is reduced substantially (PubMed:22212480).
messages: Nucleus
messages: Protein involved in the remodeling of chromatin thereby regulating various processes including transcription, chromosome synapsis and genome integrity (PubMed:22172672, PubMed:22212480, PubMed:17215300, PubMed:30929290). Mainly binds genomic loci carrying trimethylated histone H3 'Lys-36' (H3K36me3) or 'Lys-4' (H3K4me3), and acetylated histone H3 'Lys-9' (H3K9ac), 'Lys-27' (H3K27ac) (PubMed:30425042, PubMed:31118512). During meiosis, required for the presynaptic pairing of homologous chromosomal regions outside of the pairing center and for the progression of chromosome synapsis (PubMed:22172672, PubMed:22212480). Essential maternal factor required in postembryonic germline development and in maintaining germ cell identity (PubMed:12175490, PubMed:30425042). Plays an important role in maintaining genomic integrity in primordial germ cells (PGCs) during meiosis by regulating DNA double-strand break (DSB) repair and synapsis (PubMed:22212480, PubMed:30929290). Also, required for chromatin-based transcriptional silencing in PGCs and for silencing of X-linked genes in the maternal germ line (PubMed:17215300, PubMed:30929290). By retaining histone acetyltransferase, cbp-1, in euchromatin, promotes the anchoring of heterochromatin at the inner nuclear membrane in intestinal and hypodermal cells (PubMed:31118512).

6239:CELE F20D1.6
gene id: 6239:CELE_F20D1.6
uniprot id: Q93538
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
messages: The Rab3 GTPase-activating complex is a heterodimer composed of rbg-1 and rbg-2.

6239:CELE F47A4.5
gene id: 6239:CELE_F47A4.5
uniprot id: Q20500
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the patatin family.
messages: Mutant animals generate fewer progeny and slower larval development.
messages: Phospholipase that plays a critical role during oogenesis, ovulation, and/or embryogenesis.

6239:CELE F10E9.8
gene id: 6239:CELE_F10E9.8
uniprot id: P34402
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with hyls-1; leading to hyls-1 localization into newly forming centrioles.
messages: Localizes to centrosomes both in sperm and in the syncytial part of the gonad. Staining in the gonad disappears as the meiotic nuclei cellularizes to form oocytes, presumably marking the point at which the centrioles are lost during oogenesis. In newly fertilized embryos, it is localized to a discrete spot near the sperm-derived pronucleus. Then, it remains attached to the centrosome throughout the rest of development.
messages: Required for centrosome duplication. Plays a central role in determining centrosome size.
messages: centrosome

6239:CELE F42G2.5
gene id: 6239:CELE_F42G2.5
uniprot id: O17099
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F13D12.2
gene id: 6239:CELE_F13D12.2
uniprot id: Q27888
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Cytoplasm
messages: Homotetramer.

6239:CELE C29F9.7
gene id: 6239:CELE_C29F9.7
uniprot id: Q9TZC4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basal cell membrane
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Embryonic lethality due to 1.5 fold stage-onset paralysis. Mutant embryos have defects in maintaining polarization of several components involved in the assembly of dense bodies and M lines, such as integrin pat-3, unc-89 and unc-112 to muscle attachment sites (PubMed:12015115). RNAi-mediated knockdown causes sterility resulting from oocyte accumulation in the proximal gonad and distal tip cell (DTC) migration defects (33 percent of animals). Actin cytoskeleton in the proximal gonad appears disorganized (PubMed:16476426). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown in hatched embryos but not in adults causes adult-onset paralysis characterized by the collapse of myosin filaments in body wall muscles and a decrease in pharyngeal pumping (PubMed:24314125). In L1 larval stage, results in the formation of large myosin aggregates in body wall muscle cells (PubMed:22761445). In L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308). In adults, causes an increase in lifespan, resistance to heat stress and increased expression of stress response factors hsf-1, sod-3, hsp-16.2 and gst-4 (PubMed:24314125).
messages: Expressed in body wall muscle.
messages: Expression starts in body wall muscles at the 1.5-fold embryonic stage.
messages: Interacts (via protein kinase domain) with unc-112 (via N-terminus) (PubMed:12015115, PubMed:24692564). Interacts (via ANK repeats) with unc-97 (via first LIM domain) (PubMed:12015115, PubMed:17662976). Interacts (via protein kinase domain) with pat-6 (via C-terminus CH domain) (PubMed:12781130). May form a complex with unc-112, unc-97 and pat-6 (PubMed:12781130, PubMed:17662976, PubMed:24692564). Does not interact with integrin pat-3 (PubMed:12015115). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: M line
messages: Probable pseudokinase that acts as an adapter protein (PubMed:12015115, PubMed:23283987). Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc-112 to integrin-mediated attachment sites (PubMed:12015115, PubMed:23283987). Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton (PubMed:16476426). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles (PubMed:16495308). May be involved in thermotolerance and lifespan (PubMed:24314125).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F29G9.4
gene id: 6239:CELE_F29G9.4
uniprot id: G5ECG2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are sterile and display a protruding vulva phenotype (PubMed:17942488). Animals have uterine defects lacking both a uterine lumen and a utse-like process; subsequently fail to develop a differentiated uterus. Furthermore, uterine seam cell genes egl-13 and lin-11 are not expressed during late larval development (PubMed:17942488). At the L3 developmental stage, AC display either failed or delayed invasion leading to the defective removal of the gonadal basement-membrane (PubMed:15960981, PubMed:17488621). AC do not fuse (PubMed:17488621). AC specific expression of lin-3 is increased, but zmp-1, him-4 and aff-1 expression is undetectable and cdh-3 expression is reduced (PubMed:15960981, PubMed:17488621). RNAi-mediated knockdown of both isoforms results in sterility, a protruding vulva and exploded through the vulva phenotypes (PubMed:17942488, PubMed:19570917). Animals have an undifferentiated uterus and lack uterine egl-13 expression (PubMed:17942488). Animals also display an endomitotic oocytes phenotype, which is due to improper distal spermathecal valve dilation and reduced plc-1 expression in the spermatheca (PubMed:19570917). Animals have no mig-10b expression in AC (PubMed:24553288). RNAi-mediated knockdown of isoform b results in an everted/protruded vulval phenotype in adults (PubMed:23437011).
messages: Belongs to the bZIP family. Fos subfamily.
messages: Detected before the L2 molt stage (PubMed:15960981). Expressed throughout ventral uterine intermediate precursor cells (PubMed:17942488).
messages: Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3' (PubMed:23437011).
messages: Expressed in anchor cells (PubMed:15960981). Isoform a is expressed in somatic gonad cells that neighbor anchor cells (PubMed:15960981, PubMed:19570917). Isoform b is expressed in vulval cells, the uterine cells that neighbor anchor cells and the spermatheca (PubMed:15960981, PubMed:19570917).
messages: Homodimer (PubMed:23437011). Heterodimer; with jun-1 (PubMed:17942488). Interacts with kgb-1 and hda-1 (PubMed:23437011).
messages: May be phosphorylated by kgb-1. Phosphorylation at Thr-440 increases sensitivity to heavy metal stress. Phosphorylation inhibits homodimer formation, and promotes association with target promoters.
messages: Nucleus
messages: Plays a role the development of the reproductive system, controlling events including anchor cell (AC) fusion and invasion (PubMed:15960981, PubMed:17488621). Regulates downstream transcriptional targets, including zmp-1, cdh-3, him-4 and mig10b, to promote the removal of the gonadal basement membrane during AC invasion (PubMed:15960981, PubMed:24553288). Regulates aff-1 expression to promote AC fusion (PubMed:17488621). With jun-1 regulates egl-1 and lin-12 expression to allow uterine cell specification and development (PubMed:17942488).
messages: Required for ovulation (PubMed:19570917). Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917). Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 (PubMed:23437011).

6239:CELE H12I13.1
gene id: 6239:CELE_H12I13.1
uniprot id: Q9N5M9
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE C35D10.4
gene id: 6239:CELE_C35D10.4
uniprot id: Q18486
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway.
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Mitochondrion

6239:CELE Y43B11AR.2
gene id: 6239:CELE_Y43B11AR.2
uniprot id: Q9N3X5
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y104H12D.3
gene id: 6239:CELE_Y104H12D.3
uniprot id: Q966E7
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE F11E6.1
gene id: 6239:CELE_F11E6.1
uniprot id: G5ECR8
names: Similarity
messages: Belongs to the glycosyl hydrolase 30 family.

6239:CELE T07D1.4
gene id: 6239:CELE_T07D1.4
uniprot id: Q10572
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in males and hermaphrodites throughout development (PubMed:17923701, PubMed:9927456). Expressed in early embryos before morphogenesis (PubMed:17923701). In hermaphrodite embryos, first expressed at the 8-16 cell stage of development with expression peaking by the 100-cell stage (PubMed:9217163). Not expressed at the 550-cell stage of embryogenesis (PubMed:9217163).
messages: In males and hermaphrodites expressed in a subset of cells in the head and tail (PubMed:9927456). Expressed in the pharynx, intestine and in muscles from the vulva and body wall.
messages: Interacts with sup-12.
messages: Males and hermaphrodites are viable and there is no change in brood size (PubMed:9217163, PubMed:17720939, PubMed:33372658). In a sex-1(y263) mutant background or a sex-1 RNAi mutant background, males are viable, but hermaphrodites have highly reduced viability due to failure of the dosage compensation complex to assemble on X chromosomes, and the surviving animals show a reduction in brood size (PubMed:17720939, PubMed:16139225, PubMed:33372658). RNAi-mediated knockdown results in a 63% reduction in the number of eggs produced (PubMed:11303786). RNAi-mediated knockdown together with sex-1 results in hermaphrodite embryonic lethality (PubMed:21471153). This hermaphrodite-specific lethality is suppressed in a sea-2 bp283 mutant or sea-1 gk799 mutant background (PubMed:21471153).
messages: Nucleus
messages: RNA-binding protein that regulates tissue-specific alternative splicing events by binding to 5'-UGCAUG-3' and 5'-GCACG-3' elements (PubMed:17060915, PubMed:17923701, PubMed:23468662, PubMed:33372658). Also binds to poly(A), poly(G), poly(C), or poly(U) stretches of RNA (PubMed:9927456). Plays a role in the sex determination pathway and X chromosome dosage compensation, and together with sex-1 is involved in making the distinction between one and two X-chromosomes (PubMed:7821230, PubMed:21471153, PubMed:23666922, PubMed:9217163, PubMed:9927456, PubMed:16139225, PubMed:17720939, PubMed:33372658). Binds to 5'-GCAUG-3' and 5'-GCACG-3' elements in intron 6 of the pre-mRNA of the sex-determining factor xol-1 to promote its alternative splicing and together with sex-1 negatively regulates the expression of xol-1 to promote hermaphrodite development (PubMed:9217163, PubMed:33372658). Negatively regulates the expression of the active isoform of xol-1 (isoform b) by promoting intron 6 retention and the deletion of exon 7 coding sequences in hermaphrodite embryos (PubMed:33372658). Furthermore, binding to the pre-mRNA of xol-1 can also direct the use of an alternative 3' splice site enabling the xol-1 transcript to be trans-spliced to unrelated genes on chromosome 2, which also leads to xol-1 exon 7 deletion (PubMed:33372658). Does not seem to regulate the retention of introns 1 to 5 of xol-1 pre-mRNA (PubMed:33372658). Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes (PubMed:16139225, PubMed:17720939). Binds to 5'-UGCAUG-3' elements in intron 7 of the pre-mRNA of unc-32 to promote its alternative splicing in neuronal tissues (PubMed:23468662). Binds to 5'-UGCAUG-3' elements in intron 4 of the pre-mRNA of egl-15 to promote its alternative splicing in body wall muscle tissues (PubMed:17060915). Promotes binding of RNA-binding protein sup-12 to target RNA (PubMed:17923701). Plays a role in male mat…

6239:CELE Y94A7B.11
gene id: 6239:CELE_Y94A7B.11
uniprot id: A8DZ48
names: Function
names: Similarity
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

6239:CELE K04E7.3
gene id: 6239:CELE_K04E7.3
uniprot id: P55114
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y39B6A.35
gene id: 6239:CELE_Y39B6A.35
uniprot id: Q9NEU3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

6239:CELE Y48C3A.11
gene id: 6239:CELE_Y48C3A.11
uniprot id: Q9NAG1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE B0222.7
gene id: 6239:CELE_B0222.7
uniprot id: Q17459
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE T07D4.3
gene id: 6239:CELE_T07D4.3
uniprot id: Q22307
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Component of the coding region determinant (CRD)-mediated complex. Identified in mRNP granule complexes containing untranslated mRNAs. Associates with the RISC complex. Associates with the SMN complex. Associates with polysomes.
messages: Cytoplasm
messages: DRBM domains cooperate for the binding to nucleic acid but not for unwinding helicase activity. The helicase-associated domain-2 (HA2) region is essential for the duplex RNA unwinding helicase activity. The minimal transactivation region (MTAD) mediates interaction with the RNA polymerase II holoenzyme and stimulates transcriptional activation. The oligonucleotide- or oligosaccharide-binding (OB-fold) and the repeated arginine and glycine-glycine (RGG) regions are dispensable for both RNA-binding and unwinding helicase activities. The RGG region contains both nuclear localization signal (NLS) and nuclear export signal (NES) and is necessary and sufficient for nucleocytoplasmic shuttling in a RNA-independent manner.
messages: Expressed in the pachytene region of the gonad and in the oocytes.
messages: Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replication at origins of replication and cell cycle progression (By similarity). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors (PubMed:15817227). Plays several roles in post-transcriptional regulation of gene expression. Promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Also plays a role in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (By similarity).
messages: Nucleus
messages: centrosome
messages: nucleolus
messages: nucleoplasm

6239:CELE F45F2.7
gene id: 6239:CELE_F45F2.7
uniprot id: Q22976
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE C08B6.3
gene id: 6239:CELE_C08B6.3
uniprot id: N1NSH4
uniprot id: Q17815
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F59G1.7
gene id: 6239:CELE_F59G1.7
uniprot id: Q9TY03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the frataxin family.
messages: Mitochondrion
messages: Monomer. Oligomer (By similarity).
messages: Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.

6239:CELE W03F9.4
gene id: 6239:CELE_W03F9.4
uniprot id: A0A0K3ASC9
uniprot id: O16992
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE E02H4.3
gene id: 6239:CELE_E02H4.3
uniprot id: G5EDB2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
messages: Cytoplasm
messages: Expressed from embryogenesis to adulthood.
messages: Expressed in body wall, vulval and anal depressor muscles.
messages: Nucleus
messages: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to target motor neurons. Negative regulation of p38 MAPK signaling may in turn modulate the trafficking of the muscle specific receptor eva-1 to the lysosome, to ensure proper display of the eva-1 receptor on the plasma membrane of muscle cells and allow for muscle arm extension towards guidance cues.
messages: Viable, but sterile. Defective extension of body wall muscle connections or arms towards the ventral nerve cord. Reduced expression of the late endosome marker rab-7, and the eva-1 and unc-40 receptors, which are expressed in muscles, and impaired recruitment of madd-4 to the muscle membrane. Double knockout with cup-5 results in increased expression of the eva-1 receptor and rab-7 positive endosomes. Double knockout with eva-1, gex-2, madd-2, madd-4, mkk-4, unc-15, unc-60, unc-93 or unc-98 results in severe muscle arm extension defects as compared to the single knockouts. Double knockout with proteins involved in the p38 MAPK signaling pathway including cebp-1, mak-2, pmk-3 or sek-3 suppress the muscle arm extension defects and eva-1 expression defects in the madd-3 single knockout. Double knockout with dlk-1 also suppresses the eva-1 expression defect, but does not suppress the muscle arm extension defects in the madd-3 single knockout. Double knockout with cebp-1, mak-2 or pmk-3 restores the defect in the recruitment of madd-4 to the muscle membrane in the madd-3 single knockout. Furthermore, double knockout with pmk-3 restores the reduced rab-7 expression level defect in the madd-3 single knockout. Double knockout with unc-54 results in lethality. Triple knockout with unc-54, and either cebp-1, dlk-1, mak-2, pmk-3 or sek-3 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant.

6239:CELE C08F8.1
gene id: 6239:CELE_C08F8.1
uniprot id: Q17827
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Has a role in gonadogenesis.
messages: Cytoplasm
messages: Expressed in the distal cell tip of developing embryos.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
messages: Worms exhibit defects in distal cell tip migration during gonadogenesis, reduced microtubule growth rate in embryos, and larvae arrest and lethality.

6239:CELE T22D1.12
gene id: 6239:CELE_T22D1.12
uniprot id: Q9GZG8
uniprot id: V6CLI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

6239:CELE F26A1.2
gene id: 6239:CELE_F26A1.2
uniprot id: Q19802
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in most cells of the cleavage stage embryo, apart from a few cells at the posterior pole, from the 20 cell stage to the 200 cell stage (PubMed:12568714). Expressed in a few neurons in the head of young larvae (PubMed:12568714).
messages: Nucleus
messages: RNAi-mediated knockdown causes significant reduction in the expression of 21U-RNAs, upon simultaneous knockdown of fkh-3 and fkh-4.
messages: Transcription factor (By similarity). Binds to DNA sequence motif 5'-CTGTTTCA-3' (PubMed:22819322). Regulates expression of a class of small RNAs, known as 21U-RNAs, perhaps acting redundantly with fkh-4 and fkh-3 (PubMed:22819322).

6239:CELE F14A5.1
gene id: 6239:CELE_F14A5.1
uniprot id: Q19438
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F29C4.1
gene id: 6239:CELE_F29C4.1
uniprot id: P20792
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: All stages.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Head and ventral nerve cord from embryos to adults. Expressed in many sensory neurons. Subset of head neurons show coexpression with daf-4 when dauer/nondauer decision is made. Also expressed in non-neuronal cells: membraneous sheath surrounding the distal end of the intestine and in the distal tip cell of the gonad.
messages: May interact with daf-4 to regulate dauer larva development.
messages: Membrane
messages: Probably involved in a TGF-beta pathway (PubMed:10887089). May be a receptor for TGF-beta-like ligand daf-7 (PubMed:10887089). Controls the decision of whether or not larvae enter a developmentally arrested state, known as dauer, in response to environmental conditions (PubMed:10887089). Involved in regulating entry into quiescence triggered by satiety (PubMed:18316030). Involved in sensitivity to CO2 levels (PubMed:18524955). In AWC neurons, acts to promote expression of srsx-3, a member of the GPCR family (PubMed:20713521).

6239:CELE C55C3.5
gene id: 6239:CELE_C55C3.5
uniprot id: Q18867
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE C07G1.4
gene id: 6239:CELE_C07G1.4
uniprot id: Q17795
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F56B6.2
gene id: 6239:CELE_F56B6.2
uniprot id: Q8WQC0
names: Domain
names: Function
names: Subunit
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids.
messages: Interacts with egl-30.
messages: The C2 and the RGS domains are both required for its inhibitory effect on G-protein signaling.

6239:CELE D2030.5
gene id: 6239:CELE_D2030.5
uniprot id: G5EEG4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

6239:CELE Y43B11AR.5
gene id: 6239:CELE_Y43B11AR.5
uniprot id: Q86B42
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE F42F12.3
gene id: 6239:CELE_F42F12.3
uniprot id: Q20344
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

6239:CELE F31B12.1
gene id: 6239:CELE_F31B12.1
uniprot id: G5EFI8
names: Disruption Phenotype
names: Domain
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in the spermatheca, vulva, intestine and excretory cells (PubMed:15355798). Expressed in sensory neurons AWC, AFD, ASE, ASG and BAG, interneurons, ventral nerve cord neurons and tail neurons (PubMed:15355798, PubMed:23887678). Expressed in body muscles (PubMed:23887678).
messages: Interacts (via Ras-associating domain 1) with let-60 (in GTP-bound form).
messages: Only Ras-associating 1 domain is involved in the binding to let-60.
messages: RNAi-mediated knockdown results in 52 percent of animals arrested at the embryonic stage (PubMed:18369461). RNAi-mediated knockdown in larvae causes a severe decrease in brood size (PubMed:15194811). In 20 percent of animals, spermatheca dilatation is impaired causing oocyte retention in the gonad and persistent triggering of ovulatory contractions (PubMed:15194811). In L4 larvae, results in a shortened lifespan (PubMed:27184844). Prevents transcription factor hlh-30 nuclear translocation and increases lifespan in response to S.aureus infection (PubMed:27184844).
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9497345). plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the distal spermatheca valve during oocyte entry and the timing of the dilation of the spermatheca-uterine valve during oocyte exit (PubMed:23671426, PubMed:15355798, PubMed:18369461, PubMed:15194811). In a similar manner, plays an essential role in epidermal morphogenesis by regulating migration of epidermal cells during ventral closure and to a lesser extent by regulating epidermal cell dorsal intercalation (PubMed:18369461). Involved in the immune response to S.aureus bacterium by activating kinase dkf-1 via the production of DAG which in turn activates transcription factor hlh-30 (PubMed:27184844). In ASER neurons, required for adjusting the orientation behavior in salt gradients based on the memory of previous salt concentration encountered (PubMed:23887678).

6239:CELE Y54E5A.7
gene id: 6239:CELE_Y54E5A.7
uniprot id: Q9XWK4
names: Similarity
messages: Belongs to the RANBP9/10 family.

6239:CELE H06I04.4
gene id: 6239:CELE_H06I04.4
uniprot id: P37165
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

6239:CELE F45G2.1
gene id: 6239:CELE_F45G2.1
uniprot id: O62243
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C05C10.1
gene id: 6239:CELE_C05C10.1
uniprot id: Q09448
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE F11C7.1
gene id: 6239:CELE_F11C7.1
uniprot id: Q19351
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Expressed in the posterior body muscles.
messages: Forms a proton-gated ion channel with pbo-5 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Not necessary for stimulation of posterior body contraction (pBoc). Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline.
messages: Membrane
messages: No visible phenotype. Mutants exhibit normal posterior body contractions.
messages: The functional channel is a hetero-oligomer of pbo-5 and pbo-6.

6239:CELE Y56A3A.4
gene id: 6239:CELE_Y56A3A.4
uniprot id: Q9U226
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF12 family.
messages: Interacts (via histone-fold domain) with taf-4 (via the histone-fold domain) (PubMed:18854162). Interaction may facilitate the nuclear localization of taf-4 (PubMed:18854162).
messages: Nucleus
messages: Part of the general transcription factor complex TFIID (By similarity). Plays a role in recruiting taf-4 to the nucleus and thereby activating transcription initiation by RNA polymerase II, as part of the TFIID complex (PubMed:18854162).
messages: RNAi-mediated knockdown reduces nuclear localization of taf-4.
messages: The histone-fold domain mediates hetero-dimer protein-protein interactions.

6239:CELE ZK354.11
gene id: 6239:CELE_ZK354.11
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F40F8.9
gene id: 6239:CELE_F40F8.9
uniprot id: Q20229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

6239:CELE F16H11.4
gene id: 6239:CELE_F16H11.4
uniprot id: P53547
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZC373.6
gene id: 6239:CELE_ZC373.6
uniprot id: Q23262
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in the seam cells, and in the hyp7 syncytial hypodermis in the mid-L4 larval stage (PubMed:24569038). Not expressed in the cells of the developing vulva (PubMed:24569038).
messages: Nucleus
messages: Probably acts downstream of the Wnt signaling pathway.
messages: RNAi-mediated knockdown causes dumpy body shape (PubMed:24569038). Defects in cuticle integrity (PubMed:24569038).
messages: Secreted

6239:CELE C52B9.6
gene id: 6239:CELE_C52B9.6
uniprot id: Q22940
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE T22H9.3
gene id: 6239:CELE_T22H9.3
uniprot id: Q9TXN7
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE H43I07.2
gene id: 6239:CELE_H43I07.2
uniprot id: Q9UAY9
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

6239:CELE F32G8.1
gene id: 6239:CELE_F32G8.1
uniprot id: Q19975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE ZK1098.10
gene id: 6239:CELE_ZK1098.10
uniprot id: P34609
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the JIP scaffold family.
messages: Expressed in neurons of the ventral cord, retrovesicular and preanal ganglia and nerve ring, intestinal cells, seam and hypodermal cells, body wall, head muscle and pharynx.
messages: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons (PubMed:30880001).
messages: perinuclear region

6239:CELE T01G9.4
gene id: 6239:CELE_T01G9.4
uniprot id: Q22078
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

6239:CELE C35D10.9
gene id: 6239:CELE_C35D10.9
uniprot id: P30429
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Abundantly expressed during embryogenesis and to a lesser extent in larvae and adults (PubMed:1286611). Expression starts at the 100-cell stage and persists through embryogenesis (at protein level) (PubMed:9027313). Not expressed in larvae and adults (at protein level) (PubMed:9027313).
messages: Associates as an asymmetric homodimer with ced-9 (PubMed:16208361, PubMed:9027313, PubMed:15383288). Upon release from ced-9, forms an octamer, known as the apoptosome, and interacts with ced-3; the interaction results in ced-3 autoproteolytic cleavage and activation (PubMed:20434985, PubMed:24065769). The octamer (a tetramer of an asymmetric dimer) also interacts with two processed ced-3 to form a stable holoenzyme (PubMed:20434985). Interacts with sex-determining protein fem-1 (PubMed:10764728). May form a complex composed of ced-3, ced-4 and mac-1 or of ced-9, ced-4 and mac-1 (PubMed:10101135). Within the complex, interacts with ced-4 (PubMed:10101135).
messages: Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development (PubMed:3955651). During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1 (PubMed:9927601). May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway (PubMed:21901106). Regulates CEP neuron apoptosis in response to high Al(3+) levels (PubMed:23106139). During male tail morphogenesis, promotes apoptosis of the tail-spike cell upstream of ced-3 but independently of egl-1 and ced-9 (PubMed:17329362). May play a role in sex-specific cell apoptosis, probably by promoting ced-3-mediated cleavage of sex-determining protein fem-1 (PubMed:10764728). During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and ced-9 and upstream of ced-3 apoptotic pathway (PubMed:26074078). Downstream of calreticulin crt-1 and upstream of ced-3 and independently of egl-1 and ced-9, plays a role in the initial steps of axonal regrowth following axotomy (PubMed:22629231). Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3, regulates temporal cell fate patterning during larval development (PubMed:25432023). May play a role in resistance to S.typhimurium-mediated infection (PubMed:11226309).
messages: Mitochondrion
messages: Mutants exhibit a block in almost all programmed cell deaths that normally occur during development (PubMed:1286611). RNAi-mediated knockdown causes a defect in egg laying in a small proportion of animals (PubMed:25432023). Also causes a moderate increase in CEP neuron survival in response to high Al(3+) levels (PubMed:23106139). In an ain-1 mutant background, enhances the proportion of animals arrested at the larval stage, with egg-laying defects and with a ruptured vulva (PubMed:25432023).
messages: Plays a major role in programmed cell death (PubMed:1286611, PubMed:8706125). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to induce caspase ced-3 autoproteolytic cleavage and activation (PubMed:15383288, PubMed:16208361, PubMed:20434985, PubMed:24065769). Also forms a holoenzyme with processed ced-3 enhancing ced-3 activity (PubMed:20434985).
messages: Prevents programmed cell death.
messages: perinuclear region

6239:CELE C15H9.7
gene id: 6239:CELE_C15H9.7
uniprot id: Q18026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.

6239:CELE Y38F2AR.7
gene id: 6239:CELE_Y38F2AR.7
uniprot id: G5EDB6
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

6239:CELE F18C5.6
gene id: 6239:CELE_F18C5.6
uniprot id: Q19550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F56C11.1
gene id: 6239:CELE_F56C11.1
uniprot id: O61213
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in hypodermal cells.
messages: In the N-terminal section; belongs to the peroxidase family.
messages: Interacts with doxa-1 and tsp-15 (PubMed:23028364). Interacts with rho-1 (PubMed:28085666).
messages: Membrane
messages: Peroxidase activity is inhibited by aminobenzohydrazide.
messages: Plays a role in cuticle biogenesis (PubMed:11514595, PubMed:19406744, PubMed:23028364, PubMed:25480962, PubMed:18460651). In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix (PubMed:11514595, PubMed:19406744, PubMed:23028364). May regulate the production of ROS by playing a role in modulating proline catabolism (PubMed:27974198). Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens (PubMed:19406744). Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity (PubMed:28085666).
messages: RNAi-mediated knockdown results in a blistered cuticle phenotype (PubMed:23028364, PubMed:25480962). Resistant to iodide toxicity (PubMed:25480962). RNAi-mediated knockdown in combination with proline supplementation suppresses the effects of exogenous proline alone and increases reactive oxygen species production and reduces the expression of skn-1 transcriptional targets including gst-4 following infection by P.aeruginosa (PubMed:27974198). RNAi-mediated knockdown rescues the enhanced longevity and increased reactive oxygen species production defects in memo-1 mutants (PubMed:28085666). RNAi-mediated knockdown suppresses the nuclear localization of transcription factor skn-1 in memo-1 RNAi mutants (PubMed:28085666).

6239:CELE C36C5.8
gene id: 6239:CELE_C36C5.8
uniprot id: Q8ITZ5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T08G11.4
gene id: 6239:CELE_T08G11.4
uniprot id: A8WHU4
uniprot id: Q94013
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

6239:CELE C34F11.4
gene id: 6239:CELE_C34F11.4
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C30F12.1
gene id: 6239:CELE_C30F12.1
uniprot id: Q95YE2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZC3H12 family.
messages: Cytoplasm
messages: Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript (PubMed:27746047). Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes (PubMed:27746047). May play a role in the clearance of apoptotic cell corpses (PubMed:18425118).
messages: Expressed in the intestinal cells adjacent to the pharynx.
messages: Viable, but exhibit slower development and have reduced body fat (PubMed:27746047). RNAi-mediated knockdown results in increased sensitivity and reduced survival in response to lower temperatures (PubMed:27746047). RNAi-mediated knockdown results in increased expression of the transcription factor ets-4 in the nuclei of intestinal cells, which may further result in changes in the expression of genes involved in lipid metabolism (PubMed:27746047). RNAi-mediated knockdown also causes a defect in the clearance of apoptotic cell corpses in hermaphrodite gonads (PubMed:18425118).

6239:CELE T05H10.7
gene id: 6239:CELE_T05H10.7
uniprot id: Q10003
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

6239:CELE T27F7.3
gene id: 6239:CELE_T27F7.3
uniprot id: Q967F1
names: Similarity
messages: Belongs to the SUI1 family.

6239:CELE C09B9.6
gene id: 6239:CELE_C09B9.6
uniprot id: Q17856
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE ZK1010.9
gene id: 6239:CELE_ZK1010.9
uniprot id: G5EE39
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F59B2.5
gene id: 6239:CELE_F59B2.5
uniprot id: P34481
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S9 family.
messages: Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (By similarity).
messages: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity).

6239:CELE C16A3.1
gene id: 6239:CELE_C16A3.1
uniprot id: Q8MNV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA.
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

6239:CELE ZK829.4
gene id: 6239:CELE_ZK829.4
uniprot id: Q23621
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

6239:CELE T09B9.5
gene id: 6239:CELE_T09B9.5
uniprot id: Q09351
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC482.1
gene id: 6239:CELE_ZC482.1
uniprot id: O18276
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
messages: Cell membrane
messages: GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel.
messages: Postsynaptic cell membrane

6239:CELE T27D1.3
gene id: 6239:CELE_T27D1.3
uniprot id: Q09638
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in pharyngeal muscle and in AWC, ASG, ASE, ASI and ASJ sensory neurons.
messages: Probable receptor for neuropeptide ligand nlp-8 that plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons.
messages: RNAi-mediated knockdown in AWC sensory neurons results in reduced octopamine inhibition of the aversive response to 100% 1-octanol.

6239:CELE C37E2.1
gene id: 6239:CELE_C37E2.1
uniprot id: Q93353
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
messages: Mitochondrion

6239:CELE C03H5.4
gene id: 6239:CELE_C03H5.4
uniprot id: O16654
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

6239:CELE C50F7.1
gene id: 6239:CELE_C50F7.1
uniprot id: Q7YXG8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE B0244.6
gene id: 6239:CELE_B0244.6
uniprot id: Q09965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. B0244 subfamily.
messages: Cell membrane

6239:CELE R134.1
gene id: 6239:CELE_R134.1
uniprot id: Q10028
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed asymmetrically in ASE right (ASER) sensory neuron and bilaterally in ASI sensory neurons. Expressed in PVT interneuron.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE T24H10.6
gene id: 6239:CELE_T24H10.6
uniprot id: Q22752
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

6239:CELE C33G3.1
gene id: 6239:CELE_C33G3.1
uniprot id: Q8STF6
names: Disruption Phenotype
names: Function
names: Subunit
names: Tissue Specificity
messages: Component of the dystrophin glycoprotein complex (DGC) (PubMed:10996789). Interacts with zyx-1 (PubMed:18094057).
messages: Expressed in muscles of the head, body wall and vulva (PubMed:10996789, PubMed:18094057). In some animals, weaker expression is observed in the intestinal muscles (at protein level) (PubMed:10996789). Isoform a is expressed in lateral neurons SDQL and SDQR (PubMed:18094057).
messages: Mutants synergistically exhibit progressive myopathy. Overexpression of dyc-1 in dys-1 and hlh-1 double mutants, delays but does not prevent the progression of myopathy due to reduction in the proportion of abnormal muscles (PubMed:10996789). Also, reduces the locomotion and egg laying defects (PubMed:10996789). RNAi-mediated knock-down of isoform b induces a dys-1-like behavioral phenotype consisting of hyperactivity, exagerated head bending and a tendency to hypercontract (PubMed:18094057).
messages: Together with dys-1 and hlh-1, participates in a common muscular function.

6239:CELE C41G7.3
gene id: 6239:CELE_C41G7.3
uniprot id: Q93367
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed throughout the germline and in oocytes (at protein level).
messages: May interact with wago-4.
messages: RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline (PubMed:30728462). Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline (PubMed:30728462).
messages: RNAi-mediated knockdown results in increased apoptosis and increased sensitivity to DNA damage-induced apoptosis in response to ionizing radiation in the germline.
messages: The KH-like 3 domain is required for binding to RNA.
messages: perinuclear region

6239:CELE R05G6.9
gene id: 6239:CELE_R05G6.9
uniprot id: Q21756
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F14F4.3
gene id: 6239:CELE_F14F4.3
uniprot id: G5EE72
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Expressed throughout development.
messages: Heme transporter required for the export of intestinal heme to different tissues and subcellular compartments (PubMed:24836561, PubMed:28581477). Also, required for the export of vitamin B12 from the intestine of the mother to the embryo to support embryonic development (PubMed:29562169).
messages: Highly expressed in the intestine and pharynx (PubMed:24836561, PubMed:29562169). Expressed at low levels in the hypodermis and in some neurons (PubMed:24836561).
messages: RNAi-mediated knockdown in larvae does not result in any obvious developmental defects and animals are able to reach the adult gravid stage and lay eggs (PubMed:24836561). However, 80% of the eggs laid fail to hatch, and the animals that hatch do not survive beyond the L1 larval stage (PubMed:24836561). RNAi-mediated knockdown in larvae results in the heme accumulation in the intestine under low heme conditions (PubMed:28581477). RNAi-mediated knockdown in larvae results in an accumulation of vitamin B12 in the intestine and defective vitamin B12 transport from mother to dead embryos (PubMed:29562169). Furthermore, embryos of RNAi-treated mothers also have defects in vitamin B12 metabolism and have reduced levels of methionine and S-adenosylmethionine (PubMed:29562169). Double RNAi-mediated knockdown with hrg-7 in larvae results in defective heme sensing (PubMed:28581477).

6239:CELE T22A3.8
gene id: 6239:CELE_T22A3.8
uniprot id: G5ECE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y39B6A.16
gene id: 6239:CELE_Y39B6A.16
uniprot id: Q8MYP1
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in the germline.
messages: Interacts with zhp-3; the interaction is required for their localization along paired chromosomes and stability, and for the formation of chiasma during meiotic recombination.
messages: Recruited co-dependently with zhp-3 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:29521627, PubMed:30379819). In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the recombination intermediate to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1 (PubMed:29521627, PubMed:30379819). This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis (PubMed:29521627, PubMed:30379819). Negatively regulates double strand break formation to promote formation of the crossover intermediate (PubMed:30379819).

6239:CELE C28C12.3
gene id: 6239:CELE_C28C12.3
uniprot id: P50437
names: Similarity
messages: Belongs to the SXP/RAL-2 family.

6239:CELE ZC513.6
gene id: 6239:CELE_ZC513.6
uniprot id: Q23359
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Exclusively expressed in the hermaphrodite gonad (PubMed:11702779, PubMed:12296824). Expression only in cellulized oocytes (PubMed:11702779). Widely distributed throughout gonadal oocytes from the mitotic stage to the developing diakinesis stage (PubMed:12296824).
messages: Expressed in newly fertilized embryos, but is rapidly degraded after initiation of the first mitotic division (PubMed:12296824, PubMed:12781695, PubMed:16611242). Weak, if any, expression during larval stages (PubMed:11702779).
messages: No visible phenotype (PubMed:12296824). Double knockout with oma-1 results in sterility due to an oocyte maturation defect (PubMed:11702779). The oocyte maturation defect is due to a meiotic defect in oocytes in which the maturation process is initiated, but there is no progression beyond the prophase stage of meiosis and therefore the cell division process is not completed (PubMed:11702779). Animals also have a larger number of oocytes which are larger in size, but the oocytes cannot be fertilized and accumulate within the gonad (PubMed:11702779). Double RNAi-mediated knockdown with oma-1 in embryos results in more widely distributed P-granules compared to wild-type embryos, and an irregular distribution of germline proteins including pgl-1, mex-1 and pie-1 (PubMed:16611242). Double RNAi-mediated knockdown with oma-1 in larva at the L4 stage of development results in 93% embryonic lethality following the first mitotic cleavage in offspring (PubMed:16611242). Double RNAi-mediated knockdown with oma-1 in adults results in a 60% reduction in number of eggs laid (PubMed:12296824). These animals also have an expanded proximal gonad arm which contains larger number of proximal oocytes which in turn contain a larger number of germinal vesicles and higher expression of maternal mRNAs including nos-2 (PubMed:12296824, PubMed:18417623). Furthermore, after the diakinesis stage following meiosis I, the germinal vesicles have dispersed chromosomes and an abnormal distribution of P-granules (PubMed:12296824). Embryos also display cell division (PubMed:19786575, PubMed:20826530). In addition, there is increased expression of target transcripts such as taf-4 and mei-1 which also exhibit an altered localization in oocytes and embryos (PubMed:18854162, PubMed:19786575, PubMed:25261697). Reduced expression of the maternal transcriptional repressor protein pie-1 (PubMed:20826530). Triple RNAi-mediated knockdown with oma-1 and moe-3 results in a 85% reduction in number of eggs laid (Pu…
messages: Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos (PubMed:18417623). Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development (PubMed:11702779, PubMed:12296824, PubMed:12781695, PubMed:16289132, PubMed:16611242, PubMed:18854162, PubMed:18417623, PubMed:19786575, PubMed:20826530, PubMed:25261697). Also, together with oma-1, is involved in P-granule distribution during embryonic development (PubMed:16611242).
messages: centrosome

6239:CELE T07A9.6
gene id: 6239:CELE_T07A9.6
uniprot id: G5EE01
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate (PubMed:15637588). By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance (PubMed:9885576, PubMed:10209098, PubMed:10377431, PubMed:16950159, PubMed:19249087, PubMed:23995781, PubMed:10077613, PubMed:20207731). Similarly, promotes apoptosis during embryonic development by suppressing the recruitment of the prosurvival kinases akt-1/2 to the plasma membrane (PubMed:25383666). In addition, regulates Z2/Z3 germline precursor cell cycle by maintaining them arrested at the G2 stage and by controlling their growth during L1 diapause (PubMed:16631584). After sperm depletion in larvae and adult hermaphrodites, promotes germline stem cell quiescence and oocyte accumulation (PubMed:26552888). By dephosphorylating ephrin-like receptor vab-1 on tyrosine residues, negatively regulates oocyte maturation downstream of vab-1 and upstream of mpk-1, independently of daf-2 (PubMed:19853560). Plays a role in postembryonic muscle arm extensions (PubMed:18436204). Required for neurite outgrowth during AIY interneuron embryonic development (PubMed:22069193). Mainly independently of daf-2, negatively regulates vulva induction probably by inhibiting mpk-1 phosphorylation (PubMed:22916028). Both lipid and protein phosphatase activities are required for the regulation of vulva induction (PubMed:22916028).
messages: Belongs to the PTEN phosphatase protein family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in embryo, larvae and in adult germline (at protein level) (PubMed:16481471, PubMed:22916028, PubMed:19853560). Expressed at equal levels in the 6 vulva precursor cells (VPCs) of L2 larvae and in the descendant cells of the induced VPCs (at protein level) (PubMed:22916028). Expressed in the uterus (at protein level) (PubMed:22916028). Expressed in the Z2/Z3 germline precursors, oocytes, several amphid neurons and weakly in the nerve cord (at protein level) (PubMed:19853560).
messages: Interacts (via C-terminus) with vab-1 (via kinase domain); the interaction is independent of vab-1 kinase activity (PubMed:19853560). Interacts with arr-1 and mpz-1; the interaction may inhibit daf-18 (PubMed:20207731). Interacts (via C-terminus) with daf-2 (via kinase domain) (PubMed:23995781).
messages: Mutants are viable but with a shorter lifespan. They also fail to enter dauer stage under starvation conditions and 17 percent of mutants display vulval bursting (PubMed:10209098, PubMed:10377431, PubMed:20207731). Unlike in wild-type animals, germline stem cell proliferation continues following sperm depletion and Z2/Z3 germline precursors continue to proliferate during L1 diapause (PubMed:16631584, PubMed:26552888). The number of unfertilized eggs laid after sperm depletion is also increased (PubMed:26552888). Prevents constitutive dauer entry and pharynx remodeling and restores normal brood size in a daf-2 mutant background (PubMed:10209098, PubMed:10377431). Prevents increase in lifespan in an arr-1 (ok401) mutant background or in mpz-1 RNAi-mediated knockdown animals (PubMed:20207731). Suppresses the increase in ovulation rate and mpk-1 phosphorylation in distal oocytes in a vab-1 (dx31) mutant background. Restores normal axon extension of PLM neurons in a daf-2 (e1370) mutant background (PubMed:23995781). RNAi-mediated knockdown prevents arrest at the dauer larval stage in a daf-2 or age-1 mutant background (PubMed:9885576, PubMed:10077613). In addition, suppresses increased thermotolerance and fat storage and reduces daf-16 nuclear localization in a daf-2 mutant background (PubMed:19249087).
messages: Nucleus
messages: Perikaryon
messages: Phosphorylated by vab-1 on tyrosine residues which may promote daf-18 degradation.
messages: axon
messages: dendrite

6239:CELE T24H7.5
gene id: 6239:CELE_T24H7.5
uniprot id: Q7JPE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

6239:CELE F08H9.7
gene id: 6239:CELE_F08H9.7
uniprot id: Q19230
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y47D3B.4
gene id: 6239:CELE_Y47D3B.4
uniprot id: Q9XX05
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F55A4.8
gene id: 6239:CELE_F55A4.8
uniprot id: A8WFM4
uniprot id: H2KYF2
uniprot id: Q8MPU6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F13G3.4
gene id: 6239:CELE_F13G3.4
uniprot id: Q19416
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

6239:CELE K04D7.4
gene id: 6239:CELE_K04D7.4
uniprot id: P28192
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily.
messages: Membrane

6239:CELE T21B10.7
gene id: 6239:CELE_T21B10.7
uniprot id: P47207
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE B0205.3
gene id: 6239:CELE_B0205.3
uniprot id: O61742
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the proteasome subunit S5A family.
messages: Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression (PubMed:20453865, PubMed:22105480, PubMed:26828939). Involvement in UBS might be cell type specific (PubMed:20453865). Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity (PubMed:26828939). Required for fertility, sperm production, and sex determination through regulation of tra-2 protein (PubMed:17050737). Plays a role in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480).
messages: Broadly expressed with high expression in the pharynx, intestine, hypodermis and spermatheca and weak expression in the excretory cell, body wall muscle, vulva and somatic gonad.
messages: Cytoplasm
messages: Nucleus
messages: Temperature-dependent increase in lifespan with a modest increase at 20 degrees Celsius and a 30% increase in mean lifespan at 25 degrees Celsius compared to wild-type animals (PubMed:26828939). Reduced fertility with no sperm produced in the spermatheca, accumulation of a sex-determination protein tra-2 in the intestine, no embryos in the uterus, and an increase in the development time to adulthood as evidenced by an expansion of the proximal oocytes at a young adult stage (PubMed:17050737, PubMed:26828939). Reduced ubiquitin-proteasome system function (UBS), particularly in dorsorectal neurons (PubMed:20453865, PubMed:26828939). Enhanced protein stability and increased resistance to protostasis in response to thermal stress and oxidative stress induced by tert-butyl hydroperoxide (PubMed:26828939). Irregular autophagy-lysosome pathway function with increased autophagy coupled with fewer intestinal lysosomes and reduced lysosomal function (PubMed:26828939). RNAi-mediated knockdown of skn-1 or elt-2 in the null mutant results in animals which are smaller and that developmentally arrest before adulthood (PubMed:26828939). RNAi-mediated knockdown results in reduced egg laying, abnormal gonad morphology with expansion of the proximal gonad greater than that of wild-type animals, and defective degradation of polyubiquitinated proteins and leads to an accumulation of these proteins (PubMed:17050737). Also results in delayed removal of paternal mitochondria until 4-fold stage of embryonic development (PubMed:22105480).
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.

6239:CELE F33D11.10
gene id: 6239:CELE_F33D11.10
uniprot id: O44781
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE ZK1320.5
gene id: 6239:CELE_ZK1320.5
uniprot id: Q09366
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0361.5
gene id: 6239:CELE_B0361.5
uniprot id: Q10949
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

6239:CELE C06G3.1
gene id: 6239:CELE_C06G3.1
uniprot id: Q3LQX0
uniprot id: Q86PJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK829.6
gene id: 6239:CELE_ZK829.6
uniprot id: Q23623
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.

6239:CELE F26E4.4
gene id: 6239:CELE_F26E4.4
uniprot id: P90847
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F47A4.1
gene id: 6239:CELE_F47A4.1
uniprot id: G5EC54
uniprot id: G5EEX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F54C9.11
gene id: 6239:CELE_F54C9.11
uniprot id: Q20759
names: Similarity
messages: Belongs to the SEC2 family.

6239:CELE F45E4.2
gene id: 6239:CELE_F45E4.2
uniprot id: Q94230
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Chromosome
messages: First expressed in blastomeres at the two cell stage of embryogenesis (PubMed:19084000). Also expressed in germline-specific P granules of early embryos (PubMed:19084000).
messages: Nucleus
messages: Probable transcription activator (PubMed:19084000). Binds telomeric DNA containing repeats of the sequence, 5'-TTAGGC-3' (PubMed:16267406). Binds to end-1 promoter, activating end-1 expression, which is required for endoderm specification during embryonic development (PubMed:19084000).
messages: Sterile due to lack of oocytes (PubMed:25439098). Defective locomotion, marked by a 3-fold reduction in speed (PubMed:25439098). RNAi-mediated knockdown causes embryonic lethality (PubMed:19084000). RNAi-mediated knockdown substantially reduces expression of end-1 (PubMed:19084000). RNAi-mediated knockdown abolishes formation of endoderm in 3% of embryos and in 35% of embryos on a mom-5 mutant background (PubMed:19084000).

6239:CELE C27H5.3
gene id: 6239:CELE_C27H5.3
uniprot id: Q18265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

6239:CELE F17A2.5
gene id: 6239:CELE_F17A2.5
uniprot id: Q19503
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TALE/PBX homeobox family.
messages: Expressed in embryos.
messages: Expressed in head dopaminergic neurons.
messages: Nucleus
messages: Plays a role in regulating gene expression in dopaminergic neurons, acting redundantly with homeobox protein ceh-20 in head neurons (PubMed:23788625). May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-43 and ceh-20 (PubMed:23788625).
messages: Worms show no phenotype but, when also lacking ceh-20, incompletely penetrant embryonic lethality is observed.

6239:CELE Y57G11C.24
gene id: 6239:CELE_Y57G11C.24
uniprot id: A0A061ACM2
uniprot id: A0A061ACP8
uniprot id: A0A061ADW6
uniprot id: G5ED33
uniprot id: G5EFE0
uniprot id: O18250
uniprot id: Q7YTG1
names: Similarity
messages: Belongs to the EPS8 family.

6239:CELE C04F5.6
gene id: 6239:CELE_C04F5.6
uniprot id: Q9GZD2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F46B3.3
gene id: 6239:CELE_F46B3.3
uniprot id: J7SA59
uniprot id: J7SF92
uniprot id: Q9XV15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T19B10.6
gene id: 6239:CELE_T19B10.6
uniprot id: Q22557
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spartan family.
messages: Chromosome
messages: DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27871365). DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27871365). Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (PubMed:27871365). Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48.1 or cdc-48.2) recruitment (PubMed:23042605).
messages: In normal conditions, no obvious developmental or behavioral defects are observed, except that but the brood size is smaller. Upon exposure of L1 larvae to hydroxyurea, replication stress sensitivity is observed, resulting in increased sterility.
messages: Interacts with vcp/p97 (cdc-48.1 or cdc-48.2).
messages: Nucleus

6239:CELE T10C6.13
gene id: 6239:CELE_T10C6.13
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F09E8.6
gene id: 6239:CELE_F09E8.6
uniprot id: Q19269
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal muscles and mc cells.
messages: Metalloprotease.
messages: Secreted

6239:CELE F55H12.1
gene id: 6239:CELE_F55H12.1
uniprot id: P90890
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK697.7
gene id: 6239:CELE_ZK697.7
uniprot id: A0A0K3AW74
uniprot id: O61200
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y65B4BR.4
gene id: 6239:CELE_Y65B4BR.4
uniprot id: Q9N2Z7
names: Disruption Phenotype
names: Function
names: Subunit
names: Tissue Specificity
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:24805825, PubMed:19553937). Ubiquitinates klf-1 (PubMed:24805825). Required for diet restriction-mediated lifespan extension, acting in concert with Kruppel-like factor klf-1 in the intestine to perhaps modulate genes involved in lipid metabolism (PubMed:24805825, PubMed:19553937). Probably acting downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway, plays a role in the immune response to infection by the Gram-negative bacterium P.aeruginosa, at least partly in response to bacterial pore-forming toxins (PubMed:20209166).
messages: Expressed in neurons localized in the head and tail of adults.
messages: Interacts (via WW domains) with Kruppel-like factor klf-1 (PubMed:24805825). Interacts with ubiquitin-conjugating enzyme E2 ubc-18 (PubMed:19553937).
messages: RNAi-mediated knockdown increases sensitivity to paraquat, and reduces lifespan at 25 degrees Celsius, but not at 20 degrees Celsius (PubMed:19553937). Causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825, PubMed:19553937). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825, PubMed:19553937). Does not suppress extended lifespans of isp-1 or daf-2 mutants (PubMed:19553937). Hypersensitive to bacterial pore-forming toxin (PubMed:20209166).

6239:CELE F21H12.6
gene id: 6239:CELE_F21H12.6
uniprot id: Q09541
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase S8 family.
messages: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway (By similarity). Has a role in regulation of fat storage.
messages: Expressed in intestinal fat-storing cells and some head neurons.
messages: RNAi-mediated knockdown causes reduced fat storage but does not affect feeding behavior.

6239:CELE Y67D8C.22
gene id: 6239:CELE_Y67D8C.22
uniprot id: U4PRP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

6239:CELE Y32F6A.5
gene id: 6239:CELE_Y32F6A.5
uniprot id: G5EDP0
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE R05A10.4
gene id: 6239:CELE_R05A10.4
uniprot id: O45700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0375 family.
messages: Secreted

6239:CELE Y55B1BM.1
gene id: 6239:CELE_Y55B1BM.1
uniprot id: G5EF60
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Coexpressed with orai-1 in spermatheca, gonad sheath cells and intestine. Also detected in neurons in the head and in the uterine epithelial cells. Heterogeneously expressed in the intestine with strong presence in the anterior and posterior intestine and weaker in the midsection.
messages: Homodimer. Interacts with orai-1.
messages: Membrane
messages: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis.
messages: Sterility due to dysfunction of somatic cells. Affects the store-operated Ca(2+) (SOC) activity.

6239:CELE B0564.10
gene id: 6239:CELE_B0564.10
uniprot id: H9G2W7
uniprot id: H9G2W8
uniprot id: P52906
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aberrant synaptic connectivity of dorsal and ventral D-type motor neurons onto ventral and dorsal muscle.
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Expressed in D-type GABAergic motor neurons at high levels in young larvae, in which the motor circuitry is formed, and at low levels in older animals (PubMed:7997265). Also present in six non-GABAergic motor neurons and is absent from the seven non-D-type GABAergic neurons (PubMed:7997265). Expressed in DD GABAergic motor neurons and VD GABAergic motor neurons (PubMed:15882588, PubMed:26083757, PubMed:29033363).
messages: Nucleus
messages: Transcriptional regulator within D-type neurons that controls terminal differentiation (PubMed:7997265). Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid-secreting) D-type motor neurons, which control locomotion (PubMed:7997265). Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1 (PubMed:26083757). Also required for expression of flp-13 in DD motor neurons (PubMed:15882588). Plays a role in respecification of DD motor neurons through regulation of genes involved in the modulation of cellular cAMP including pde-4 which hydrolyzes cAMP and acy-1 which catalyzes cAMP formation (PubMed:29033363).

6239:CELE F57H12.7
gene id: 6239:CELE_F57H12.7
uniprot id: O45100
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Expressed in touch receptors from late embryos to adults.
messages: Expressed solely in touch receptor neurons.
messages: Mutants are partially insensitive to body touch.
messages: Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.

6239:CELE R07B7.16
gene id: 6239:CELE_R07B7.16
uniprot id: Q21806
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Transcription up-regulated in response to intestinal colonization by probiotic Lactobacillus fermentum strain JDFM216.
messages: Transcriptional regulator (By similarity). Plays a role in modulation of lifespan and immunity (PubMed:29748542).

6239:CELE C53C9.3
gene id: 6239:CELE_C53C9.3
uniprot id: H2KZE7
uniprot id: Q7JPF0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05A7.3
gene id: 6239:CELE_T05A7.3
uniprot id: Q22206
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C56C10.3
gene id: 6239:CELE_C56C10.3
uniprot id: Q18886
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE ZK418.7
gene id: 6239:CELE_ZK418.7
uniprot id: Q23485
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F55A12.9
gene id: 6239:CELE_F55A12.9
uniprot id: H2KZ00
uniprot id: H2KZ01
uniprot id: Q86NJ5
uniprot id: Q95R13
names: Similarity
messages: Belongs to the TENT family.

6239:CELE ZK185.2
gene id: 6239:CELE_ZK185.2
uniprot id: O44196
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

6239:CELE Y43H11AL.1
gene id: 6239:CELE_Y43H11AL.1
uniprot id: A0A0K3AR60
uniprot id: A0A0K3AUR6
uniprot id: A0A0K3AX31
uniprot id: H2L057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

6239:CELE F15B9.9
gene id: 6239:CELE_F15B9.9
uniprot id: Q7YXD2
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE R13A5.8
gene id: 6239:CELE_R13A5.8
uniprot id: Q95Y90
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

6239:CELE M03E7.5
gene id: 6239:CELE_M03E7.5
uniprot id: Q21499
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

6239:CELE C41G7.9
gene id: 6239:CELE_C41G7.9
uniprot id: B3WFW9
uniprot id: C7FZU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

6239:CELE Y53F4B.13
gene id: 6239:CELE_Y53F4B.13
uniprot id: Q9NAA5
names: Function
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation.

6239:CELE F20G2.4
gene id: 6239:CELE_F20G2.4
uniprot id: Q93542
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y62E10A.15
gene id: 6239:CELE_Y62E10A.15
uniprot id: I2HAA9
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C15F1.4
gene id: 6239:CELE_C15F1.4
uniprot id: P80361
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B gamma/epsilon subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

6239:CELE R13A5.4
gene id: 6239:CELE_R13A5.4
uniprot id: Q95Y94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F25B5.6
gene id: 6239:CELE_F25B5.6
uniprot id: Q09509
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Cytoplasm
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Produced by alternative initiation at Met-27 of isoform a.
messages: Produced by alternative splicing.

6239:CELE T08G11.3
gene id: 6239:CELE_T08G11.3
uniprot id: Q94012
names: Similarity
messages: Belongs to the FAM154 family.

6239:CELE T10B11.6
gene id: 6239:CELE_T10B11.6
uniprot id: Q9TZH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

6239:CELE F17E5.2
gene id: 6239:CELE_F17E5.2
uniprot id: Q19529
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Calcium-dependent mitochondrial solute carrier.
messages: Mitochondrion inner membrane

6239:CELE C04E7.2
gene id: 6239:CELE_C04E7.2
uniprot id: Q11193
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in embryos, larvae and adults.
messages: Expressed ubiquitously.
messages: Nucleus
messages: Probably acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes in order to regulate various neurogenic identities. Specification of some neuronal identities also involves expression of non-Hox genes. Specifies dopaminergic and serotonergic neuronal cell fate, and regulates neurotransmitter choice and axon pathfinding.
messages: Worms exhibit ectopic expression of Hox genes and homeotic transformations. Mutants are also long and exhibit defects in distal tip cell migration.

6239:CELE B0334.8
gene id: 6239:CELE_B0334.8
uniprot id: Q94125
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.
messages: Expressed both maternally and zygotically.
messages: Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause (PubMed:8700226, PubMed:21750263). Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3 (PubMed:25383666). Could function in the development or neuroendocrine signaling of the dauer pathway (PubMed:8700226). Mediates susceptibility to enteropathogenic E.coli infection (PubMed:16091039). May negatively regulate AYI interneuron neurite outgrowth (PubMed:22069193). Plays a role in aversive olfactory learning when an odor is associated with food deprivation (PubMed:27383131). Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning (PubMed:27383131).

6239:CELE B0336.10
gene id: 6239:CELE_B0336.10
uniprot id: P48158
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

6239:CELE T10B11.1
gene id: 6239:CELE_T10B11.1
uniprot id: Q9TZH6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

6239:CELE T13C2.4
gene id: 6239:CELE_T13C2.4
uniprot id: Q22453
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SSU72 phosphatase family.
messages: Expressed in embryos, larvae and adults.
messages: Expressed in epidermis, intestine and nervous system.
messages: May be phosphorylated by kin-20.
messages: May interact with synd-1 (via C-terminus); the interaction may prevent ssup-72 binding to RNA polymerase II ama-1 (PubMed:26588990). May interact with RNA polymerase II ama-1 (Probable).
messages: Nucleus
messages: Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1 (PubMed:26588990). By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre-mRNAs, including unc-44 and dlk-1 mRNAs (PubMed:26588990, PubMed:28087624). This results in the tissue-specific expression of unc-44 isoforms (PubMed:28087624).

6239:CELE D2096.2
gene id: 6239:CELE_D2096.2
uniprot id: H2KZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

6239:CELE W08E3.2
gene id: 6239:CELE_W08E3.2
uniprot id: G5EDE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus speckle

6239:CELE F44E5.5
gene id: 6239:CELE_F44E5.5
uniprot id: G5ECU5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE F57F5.2
gene id: 6239:CELE_F57F5.2
uniprot id: H2L2D1
uniprot id: P90895
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in BAG sensory neuron.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221).
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE C03B1.12
gene id: 6239:CELE_C03B1.12
uniprot id: Q11117
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Membrane
messages: Present from early embryonic stages through adulthood.

6239:CELE K10G9.1
gene id: 6239:CELE_K10G9.1
uniprot id: G5EEK1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C15H11.4
gene id: 6239:CELE_C15H11.4
uniprot id: Q9XVS9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F28H1.3
gene id: 6239:CELE_F28H1.3
uniprot id: O01541
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Monomer.

6239:CELE R07B1.1
gene id: 6239:CELE_R07B1.1
uniprot id: Q09604
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Msh homeobox family.
messages: Expressed from the twofold embryo stage through to L4 larval stage (PubMed:11333230). Expressed in the embryonic mother cell of Q and V5 neuroblasts, AB.p(lr)apapaa, and abolished in V5 neuroblasts after division but maintained in Q cells until they divide (PubMed:28716930). Expressed in P-neuroblasts before hatching, maintained while P nuclei migrate into the ventral midline in early L1-stage larvae, and declines after P-neuroblasts divide (PubMed:28716930).
messages: Expressed in the ectodermal cells of embryos and seam cells and ventral cord motor neurons of young larvae.
messages: Nucleus
messages: Probable transcription factor needed for the proper production of touch cell precursors (PubMed:11333230). Involved in specification of lateral neuroblasts (PubMed:28716930). Essential for embryonic morphogenesis (PubMed:11333230).
messages: Worms exhibit the absence of AVM, PVM, and PLM touch cells, defective egg laying, embryonic or larval lethality, cell degeneration, malformation of the posterior body, and uncoordinated movement.

6239:CELE T11F9.4
gene id: 6239:CELE_T11F9.4
uniprot id: Q22397
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility (PubMed:30560135).
messages: Apical cell membrane
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Expressed at the apical cell membrane of intestinal cells.
messages: Interacts (via PDZ-binding motif) with nfrl-1 (via PDZ 2 domain); the interaction with nrfl-1 is required to sequester aat-6 to the apical cell membrane of intestinal cells.

6239:CELE F59E10.2
gene id: 6239:CELE_F59E10.2
uniprot id: P52012
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in the early larval stages with lower levels at later larval and adult stages.
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Exclusively in the larval body wall striated muscle cells.
messages: Interacts with mep-1.
messages: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development.
messages: Nucleus

6239:CELE D2030.10
gene id: 6239:CELE_D2030.10
uniprot id: G5EEU3
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the unc-13 family.
messages: Expressed in intestine, body wall muscles and some amphid neurons.
messages: Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells (PubMed:11804572, PubMed:2323555, PubMed:19028454). Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ) (PubMed:11804572). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:11804572, PubMed:2323555, PubMed:19028454). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides (PubMed:25849533). Regulates locomotion (PubMed:11804572).
messages: Severely constipated due to absent or weak anterior body muscle (aBOC) and intestinal contractions during the defecation cycle (PubMed:11804572, PubMed:2323555). Reduced uptake and accumulation of triglycerides (PubMed:25849533). Locomotion defects characterized by mild body thrashing (PubMed:11804572). Partially resistant to paralysis induced by acetylcholine esterase inhibitor aldicarb (PubMed:2323555, PubMed:19028454). Reduced enrichment of unc-13 at presynaptic active sites of neuromuscular junctions (PubMed:11804572).

6239:CELE ZK686.4
gene id: 6239:CELE_ZK686.4
uniprot id: P34670
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F55C10.4
gene id: 6239:CELE_F55C10.4
uniprot id: Q20806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 92 family.
messages: Membrane

6239:CELE E03H4.5
gene id: 6239:CELE_E03H4.5
uniprot id: O17745
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C38C10.4
gene id: 6239:CELE_C38C10.4
uniprot id: Q03569
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122).
messages: Interacts with gpr-1; gpr-1 forms a complex with lin-5 and GDP-bound goa-1.
messages: Simultaneous RNAi-mediated knockdown of both gpr-1 and gpr-2 causes, in the 1-cell embryo, a decrease in nuclear and spindle movements during prophase, reduced asymmetric spindle elongation during anaphase and mispositioning of nuclei after cell division.
messages: cell cortex
messages: spindle

6239:CELE F41H10.5
gene id: 6239:CELE_F41H10.5
uniprot id: Q20297
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T03D8.3
gene id: 6239:CELE_T03D8.3
uniprot id: Q9XTY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

6239:CELE Y55B1AL.3
gene id: 6239:CELE_Y55B1AL.3
uniprot id: H2KY86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Chromosome
messages: Nucleus
messages: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:18472307, PubMed:34880204). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed:34880204).

6239:CELE Y54G2A.31
gene id: 6239:CELE_Y54G2A.31
uniprot id: Q95XX0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Has no ubiquitin ligase activity on its own; may require ubiquitin-conjugating enzyme, ubc-13.
messages: Interacts with the E3 ubiquitin ligase nhl-1 and the E2 ubiquitin ligase ubc-1 (PubMed:15530417). Heterodimer with uev-1 (PubMed:15530417, PubMed:21179194).
messages: Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772). May have a role in AMPA-type glutamate receptor trafficking in neurons (PubMed:21179194).
messages: Temperature sensitive with partial embryonic lethality at 25 degrees Celsius (PubMed:24595290). Inhibited degradation of maternal membrane proteins, cav-1, chs-1 and rme-2, and ubiquitination of cav-1 with accumulation of these proteins on the maternal plasma membrane and endosome-like vesicles in later-stage embryos (PubMed:24595290). RNAi-mediated knockdown prevents localization of ubiquitin and proteasomes to polyglutamine protein aggregates (PubMed:17663792). Reduced growth of polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772). Inhibited degradation of maternal membrane protein, cav-1 in embryos (PubMed:24595290).

6239:CELE F37H8.4
gene id: 6239:CELE_F37H8.4
uniprot id: O17863
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE R05G6.6
gene id: 6239:CELE_R05G6.6
uniprot id: Q21751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

6239:CELE F31D4.7
gene id: 6239:CELE_F31D4.7
uniprot id: O45422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F17C11.9
gene id: 6239:CELE_F17C11.9
uniprot id: P54412
names: Disruption Phenotype
names: Function
names: PTM
names: Subunit
messages: AMPylated by fic-1.
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.
messages: RNAi-mediated knockdown results in 100% sterility at 25 degrees Celsius.

6239:CELE C07A12.4
gene id: 6239:CELE_C07A12.4
uniprot id: Q17770
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Expressed in oscillating waves in hypodermal cells during the 4 larval stages and in adults.
messages: Heterotetramer of two alpha chains and two beta chains. Exist either as a phy-1(2)/pdi-2(2) tetramer, a phy-2(2)/pdi-2(2) tetramer or as a phy-1/phy-2/pdi-2(2) tetramer.
messages: Involved in cuticle formation (PubMed:10805750). May play a role in the unfolded protein response (PubMed:21199936).
messages: RNAi-mediated knockdown causes embryonic lethality characterized by a retraction of the fully elongated embryo, a progressive disorganization of the embryo and a failure to hatch (PubMed:10805750). Also causes increased expression of the unfolded protein response (UPR) marker hsp-4 (PubMed:21199936).

6239:CELE R151.2
gene id: 6239:CELE_R151.2
uniprot id: Q21994
uniprot id: Q6AHR3
uniprot id: Q95QB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

6239:CELE C02D5.3
gene id: 6239:CELE_C02D5.3
uniprot id: P34277
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).

6239:CELE T19D12.5
gene id: 6239:CELE_T19D12.5
uniprot id: Q22573
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE C14B1.4
gene id: 6239:CELE_C14B1.4
uniprot id: Q17963
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat WDR5/wds family.
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (PubMed:31602465). Within the complex, interacts with cfp-1, ash-2, dpy-30 and hda-1 (PubMed:31602465). Interacts with histone H3 both unmethylated and methylated at 'Lys-4' (PubMed:21455483). Interacts with jmjd-3.1, ceh-6, sox-2, sem-4 and egl-27 (PubMed:25124442). Interacts with set-2 (PubMed:21527717).
messages: Contributes to histone modification (PubMed:16710447, PubMed:17967446, PubMed:20188723, PubMed:20555324, PubMed:21455483, PubMed:22012258). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:21455483). Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3 (PubMed:20555324, PubMed:21455483, PubMed:24682813, PubMed:21527717). Not required for demethylation of histone H3 'Lys-27' (PubMed:21455483). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function (PubMed:21455483). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:17967446, PubMed:20555324, PubMed:28379943). Required for RNA interference with probable antagonistic role against hpl-2 function (PubMed:17967446). Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2 (PubMed:17967446). Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development (PubMed:24682813). Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate (PubMed:24682813). Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
messages: Detected from the 20 cell embryo stage and continues through to adult, although in a restricted manner.
messages: Enriched in the germline (PubMed:17967446, PubMed:24682813). Detected in all nuclei of the embryo (PubMed:17967446). In larvae, expression is detected in the nuclei of seam cells, somatic gonad precursor cells Z1 and Z4, vulval precursor cells, distal tip cells, hypodermal cells, intestinal and muscle cells (PubMed:17967446). Also detected in the neurons from the ventral nerve cord, head and tail region (PubMed:17967446). Expressed in the head and tail region, intestinal cells, muscle cells, cells of the vulva, spermatheca and sheath cells in adults (PubMed:17967446).
messages: Increase in life span (PubMed:17967446). Longer time span to reach adulthood and reduced brood size resulting in sterility between generations F3 and F4 (PubMed:17967446). Associated embryonic lethality and additional somatic defects at elevated temperatures (PubMed:17967446). Defects in germ cells including defective sperm development and endomitotic oocytes (PubMed:17967446, PubMed:24682813). Significantly reduced H3 'Lys-4' trimethylation in both embryonic and adult germ cells in a sex-independent manner (PubMed:17967446). Increased fog-3 expression at 20 degrees Celsius (PubMed:24682813). At 20 and 25 degrees Celsius, double knockdown mutants with wdr-5.2 have increased fog-3 expression (PubMed:24682813). At 25 degrees Celsius, these mutants have increased wdr-5.2 and fog-1 expression, reduced brood size accompanied by 42% embryonic lethality with 100% of the surviving progeny being sterile (PubMed:24682813). Surviving progeny display enhanced defects in the spermatogenesis to oogenesis transition compared to the single wdr-5.1 knockout with 88% of the gonads only containing sperm (PubMed:24682813). The remaining germ cells in the gonads switch to oogenesis, but the oocytes display either an endoreplication or endomitotic phenotype (PubMed:24682813). Germ cells also have increased expression of the sex determining factor tra-1 in the cytoplasm and as a result there is reduced binding of tra-1 to the fog-3 promoter (PubMed:24682813). RNAi-mediated knockdown leads to an enrichment of mono-unsaturated fatty acids (PubMed:28379943).
messages: Nucleus

6239:CELE C50E10.11
gene id: 6239:CELE_C50E10.11
uniprot id: A3QMA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y47G6A.20
gene id: 6239:CELE_Y47G6A.20
uniprot id: Q9N3S4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation (Probable). Ensures the correct splicing of genes involved in immunity to promote longevity in response to infection by pathogenic bacteria such as S.aureus (PubMed:32538777).
messages: Nucleus
messages: RNAi-mediated knockdown increases survival following infection by pathogenic bacteria S.aureus (PubMed:32538777). RNAi-mediated knockdown impairs the splicing of genes such as prg-2 and tos-1 following infection by S.aureus (PubMed:32538777). RNAi-mediated knockdown induces the expression of nlp-34, lys-3, irg-2, irg-1, M01G12.9, fmo-2 and cyp-37B1 under non-infected conditions (PubMed:32538777). RNAi-mediated knockdown increases the phosphorylation of pmk-1 (PubMed:32538777).
messages: The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions.

6239:CELE C50E3.16
gene id: 6239:CELE_C50E3.16
uniprot id: Q22931
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

6239:CELE T05B4.9
gene id: 6239:CELE_T05B4.9
uniprot id: O16418
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F33H1.1
gene id: 6239:CELE_F33H1.1
uniprot id: Q09555
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RFX family.
messages: Ciliated sensory neurons.
messages: Expressed in the male tail HOB and RnB neurons but not in male-specific CEM head neurons or other ciliated neurons.
messages: Expressed in the male-specific ciliated sensory neurons, including the two hook neurons, and the 36 ray neurons at the L4 larval stage.
messages: Involved in male mating behavior; may play a role in functional specialization of PKD ciliated sensory neurons.
messages: Nucleus
messages: Probable transcription factor (PubMed:10882127, PubMed:12954713). May regulate some genes of ciliated sensory neurons (PubMed:10882127, PubMed:12954713). May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression (PubMed:10882127, PubMed:12954713). Together with transcription factor atf-7, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381).

6239:CELE T23F1.7
gene id: 6239:CELE_T23F1.7
uniprot id: Q7JKY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell membrane
messages: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.

6239:CELE B0454.6
gene id: 6239:CELE_B0454.6
uniprot id: O17167
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W01B6.5
gene id: 6239:CELE_W01B6.5
uniprot id: Q23102
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y39G10AR.21
gene id: 6239:CELE_Y39G10AR.21
uniprot id: Q95XR2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Expression increases during the larval stages to adulthood.
messages: Mitochondrial methyltransferase which methylates cytosine to 5-methylcytosine (m5C) in rRNAs and tRNAs at multiple sites (PubMed:33283887). May play a role in the translation of leucine and proline codons (Probable).
messages: Mitochondrion
messages: RNAi-mediated knockdown does not result in fertility defects.

6239:CELE C17B7.5
gene id: 6239:CELE_C17B7.5
uniprot id: O45155
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE F46F11.1
gene id: 6239:CELE_F46F11.1
uniprot id: P91309
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
messages: The N-terminal kinase domain produces inositol polyphosphates. The C-terminal acid phosphatase-like domain binds inositol polyphosphates and negatively regulates their accumulation. The C-terminal domain reduces the amount of inositol pyrophosphates in a dose-dependent manner in vitro.
messages: cytosol

6239:CELE T26A5.3
gene id: 6239:CELE_T26A5.3
uniprot id: Q22800
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

6239:CELE F08G12.10
gene id: 6239:CELE_F08G12.10
uniprot id: Q9U3K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE T01B11.3
gene id: 6239:CELE_T01B11.3
uniprot id: P91409
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

6239:CELE Y19D10A.12
gene id: 6239:CELE_Y19D10A.12
uniprot id: A0A0M7RFF6
uniprot id: Q9UAT3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H05B21.4
gene id: 6239:CELE_H05B21.4
uniprot id: O61971
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C08C3.2
gene id: 6239:CELE_C08C3.2
uniprot id: P34324
names: Function
names: Subunit
messages: Interacts with cul-3.
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

6239:CELE Y47D3A.6
gene id: 6239:CELE_Y47D3A.6
uniprot id: P34708
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Expressed in intestine and gonads (at protein level).
messages: Interacts with the MX regulatory domain of tra-2.
messages: Isoform b is expressed abundantly in second larval (L2) stage. Isoform a is more abundant in embryos.
messages: Nucleus
messages: Only isoform a (Tra-1L), is thought to bind DNA. Zinc fingers 3, 4 and 5 are the most important for DNA binding; removal of finger 5 almost abolishes DNA binding and prevents the selection of binding sites.
messages: Plays a major role in controlling sexual phenotype (PubMed:1339311). Terminal global regulator in a well-characterized cascade of sex-determining genes (PubMed:8367286). Promotes female development (PubMed:11124807). Interacts with tra-2 to promote spermatogenesis (PubMed:11250902). Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (PubMed:24682813). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By similarity). In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (PubMed:18056428). Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis (PubMed:18550714). Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features (PubMed:28065609).

6239:CELE F49E12.6
gene id: 6239:CELE_F49E12.6
uniprot id: Q20619
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Expressed in embryos, larvae and adults (PubMed:21596899). Expression begins in multiple cells in embryos, reaching a maximum in the L1-L2 larval stages (PubMed:21596899). Expressed in the ventral nerve cord VA and VB neurons, but not in the VC neurons (PubMed:21596899).
messages: Nucleus
messages: Probable transcription factor which represses gene expression in a subset of ventral nerve cord neurons (PubMed:21596899). Involved in regulating programmed cell death and determining cell fate during development, acting in a partially redundant manner with lin-39 to repress the BH3 domain-encoding gene egl-1 in the VA and VB motor neurons (PubMed:21596899).
messages: RNAi-mediated knockdown on a ced-3 mutant background results in ectopic egl-1 expression in posterior ventral nerve cord neurons (PubMed:21596899). RNAi-mediated knockdown on a simultaneous lin-39; ced-3 mutant background results in ectopic egl-1 expression in midbody and posterior ventral nerve cord neurons (PubMed:21596899).

6239:CELE Y22D7AL.10
gene id: 6239:CELE_Y22D7AL.10
uniprot id: Q965Q1
names: Similarity
messages: Belongs to the GroES chaperonin family.

6239:CELE F11G11.2
gene id: 6239:CELE_F11G11.2
uniprot id: P91253
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).

6239:CELE C47A10.4
gene id: 6239:CELE_C47A10.4
uniprot id: O45306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE K07E3.7
gene id: 6239:CELE_K07E3.7
uniprot id: A0A131MBX4
uniprot id: Q21286
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Disrupts the polyamine uptake and/or transport of the polyamine conjugate Ant-4,4 and norspermidine, a toxic structural analog of the polyamine spermidine. Intracellular levels of the natural polyamines spermidine and putrescine are as wild-type. Double knockout with either odc-1 or smd-1 (two enzymes involved in polyamine synthesis) results in a reduced brood size, delayed postembryonic development and reduced intracellular levels of spermidine. Double knockout with odc-1 results in reduced levels of the polyamine putrescine, while double knockout with smd-1 results in increased accumulation of putrescine.
messages: Expressed in the 20 intestinal cells and in the excretory cell.
messages: Involved in the uptake and/or transport of polyamines, probably through ATP hydrolysis. This contributes to the maintenance of intracellular polyamine levels. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Membrane
messages: Not expressed in embryos, but expressed at all larval stages of development and in adults.

6239:CELE C26E6.9
gene id: 6239:CELE_C26E6.9
uniprot id: Q18221
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2.
messages: Expressed in all cells of embryo. In L1 larva, it is predominantly expressed in Z2 and Z3 primordial germ cells. In adults, it is predominantly expressed in the germline.
messages: Expressed throughout embryogenesis.
messages: Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells (PubMed:21527717, PubMed:20555324). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:21527717). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:20555324, PubMed:28379943). Methylation in the germline is required for germline development and fertility, possibly by ensuring genome stability (PubMed:21527717, PubMed:12242227). May act redundantly with mes-3 and mes-4 proteins in the development of a fertile germline (PubMed:11729150). Required for RNAi (PubMed:17967446). Functions as an antagonist of hpl-1 and hpl-2 activity in growth and somatic gonad development (PubMed:17967446). Cooperates with jmjd-3.1 and egl-27 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
messages: Nucleus
messages: RNAi-mediated knockdown results in disruption of invariant Y-to-PDA transdifferentiation (PubMed:25124442). Results in decreased trimethylation at 'Lys-4' of histone H3 (PubMed:20555324). Leads to an extension of lifespan (PubMed:20555324). Leads to a deregulation of fat metabolism and to an enrichment of mono-unsaturated fatty acids (PubMed:28379943).

6239:CELE T07H3.4
gene id: 6239:CELE_T07H3.4
uniprot id: O76608
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F54F3.3
gene id: 6239:CELE_F54F3.3
uniprot id: Q93789
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lipase that, together with lipl-3, plays a role in the response to nutrient deprivation by controlling lipid metabolism (PubMed:23604316). Specifically, involved in the breakdown of lipids during lipophagy, a process during which lipids contained in lipid droplets that have been delivered to lysosomes by autophagy are degraded (PubMed:23604316).
messages: Lysosome lumen
messages: Secreted
messages: Up-regulated in the intestine by fasting (PubMed:23604316). Down-regulated in response to a high-glucose diet (PubMed:29113111).

6239:CELE C27A12.5
gene id: 6239:CELE_C27A12.5
uniprot id: G5ECT8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EMX homeobox family.
messages: Can substitute for ems in D.melanogaster ems mutants, partially rescuing the mutant phenotype.
messages: Earliest expression is detected in late gastrulation (at protein level). Expression is strongest in elongated embryos and early larvae.
messages: In the anterior pharynx, expressed in the I3 interneuron, the NSM and M3 motor neuron pairs, the three m2 muscle cells and the three e2 epithelial cells (at protein level).
messages: Mutants lacking the homeobox domain are viable and fertile but proliferate slightly more slowly than wild-type due to retarded larval development and reduced brood size. About 20% appear starved as they are shorter, thinner and paler at all stages with severely affected adults bearing only a few eggs. M3 neuron activity is decreased.
messages: Nucleus
messages: Required for activity of the M3 pharyngeal motor neuron.

6239:CELE Y41D4B.27
gene id: 6239:CELE_Y41D4B.27
uniprot id: A2V8C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK1025.4
gene id: 6239:CELE_ZK1025.4
uniprot id: Q18LB5
uniprot id: Q9XXL9
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C06A1.5
gene id: 6239:CELE_C06A1.5
uniprot id: Q17684
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
messages: Nucleus

6239:CELE Y71F9B.4
gene id: 6239:CELE_Y71F9B.4
uniprot id: Q9N4G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

6239:CELE K03E5.3
gene id: 6239:CELE_K03E5.3
uniprot id: O61847
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Binds 2 Mg(2+) ions.
messages: Interacts with cye-1 (By similarity); the interaction likely regulates cdk-2 activity and is probably required for gld-1 phosphorylation.
messages: RNAi-mediated knockdown causes arrest at various developmental stages. The few animals reaching adulthood are sterile and have a protruding vulva (PubMed:10207147). Gonads have an abnormal mitotic zone characterized by an enlargement of the distal germ cell nuclei, a reduction in the number of mitotic germ cells, a reduction in the mitotic region length and abnormal expression of gld-1 (PubMed:21455289). Embryos have persistent ruffling throughout the cortex and mislocalization of par-2, which remains cytoplasmic, and par-6, which remains distributed throughout the cortex. In 33 percent of embryos the first division is symmetric (PubMed:17115027). Production of 2 additional distal tip cells (DTC) during larval development (PubMed:17476329). RNAi-mediated knockdown in embryos causes a slight delay in cell cycle progression (PubMed:17115027).
messages: Serine/threonine-protein kinase which, in association with cye-1, regulates proliferation, quiescent state and cell fate during the development of several cell lineages (PubMed:17115027. PubMed:17476329). In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase (PubMed:17115027). Phosphorylation and inhibition of the translational repressor gld-1 by the cdk-2/cye-1 complex regulates the pool of germline stem cells and the size of the mitotic zone in the gonads by preventing entry into meiosis (PubMed:21455289).

6239:CELE F53F1.11
gene id: 6239:CELE_F53F1.11
uniprot id: P92002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F59A6.1
gene id: 6239:CELE_F59A6.1
uniprot id: A0A0K3ATZ5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

6239:CELE Y48G8AL.8
gene id: 6239:CELE_Y48G8AL.8
uniprot id: Q9BL19
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

6239:CELE R05D3.7
gene id: 6239:CELE_R05D3.7
uniprot id: P34540
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
messages: Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
messages: Conditional knockout in PVD neuron results in a complete microtubule polarity reversal in the anterior dendrite (PubMed:30254025). Conditional knockout in motor neuron reduces the number of mitochondria in the axon (PubMed:30254025). RNAi-mediated knockdown results in reduced dendritic branch formation in PVD sensory neurons (PubMed:21205795). RNAi-mediated knockdown results in an altered distribution of recycling and late endosomes (PubMed:22634595). RNAi-mediated knockdown results in defects in nuclear migration in hyp7 hypodermal precursor cells (PubMed:27697906). RNAi-mediated knockdown in a dhc-1 (js319) mutant background results in defective nuclei migrations in larval hypodermal P-cells (PubMed:27697906).
messages: Cytoplasm
messages: Microtubule-dependent motor protein required for organelle transport (PubMed:22634595, PubMed:30254025). Plays a role in endosome transport (PubMed:22634595). Required for the transport of mitochondria along the axon of motor neurons (PubMed:30254025). Involved in the nuclear migration of hyp7 hypodermal precursor cells (PubMed:19605495, PubMed:27697906). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795). In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites (PubMed:30254025). Involved in the localization of unc-33 to neurites (PubMed:16236031).
messages: Oligomer composed of two heavy chains and two light chains.
messages: cytoskeleton

6239:CELE Y54E10BL.2
gene id: 6239:CELE_Y54E10BL.2
uniprot id: Q9N3D7
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T05B4.11
gene id: 6239:CELE_T05B4.11
uniprot id: O16420
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K03E6.5
gene id: 6239:CELE_K03E6.5
uniprot id: G5ED08
uniprot id: Q21190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Cell membrane
messages: gap junction

6239:CELE T12G3.5
gene id: 6239:CELE_T12G3.5
uniprot id: Q22438
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
messages: Mitochondrion

6239:CELE T19D12.10
gene id: 6239:CELE_T19D12.10
uniprot id: O76838
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R04B5.9
gene id: 6239:CELE_R04B5.9
uniprot id: Q21706
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE K11C4.2
gene id: 6239:CELE_K11C4.2
uniprot id: Q94276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE C32A3.1
gene id: 6239:CELE_C32A3.1
uniprot id: Q09260
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a complex consisting of at least a lin-12/Notch intracellular domain (NICD), lag-1, and lag-3 (PubMed:10830967, PubMed:16530045). Interacts with a NICD of lin-12/Notch or glp-1/Notch; the interactions are direct (PubMed:10830967, PubMed:16530045).
messages: Expressed in the progenitor zone and the early pachytene region of the hermaphrodite gonad.
messages: Nucleus
messages: RNAi-mediated knockdown causes multiple defects, including large vulval protrusions in hermaphrodites, premature differentiation of germ cells as sperm, and embryonic arrest around the onset of morphogenesis (PubMed:10884418). RNAi-mediated knockdown causes a partial decrease in apoptosis in germ line cells, in the F1 generation, induced by gamma-irradiation (PubMed:17317671). RNAi-mediated knockdown, during treatment by gamma-irradiation, reduces the expression of the p53 target genes, ced-13 and egl-1 (PubMed:17317671).
messages: glp-1/Notch and lin-12/Notch proteins promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator, probably as part of a complex with a Notch intracellular domain (NICD) and the transcription regulator lag-1 (PubMed:10830967, PubMed:10884418, PubMed:16530045). Involved in the p53-mediated germ-cell apoptotic response to DNA damage, perhaps acting as a transcriptional activator (PubMed:17317671). May regulate phosphatase lip-1 mRNA transcription downstream of glp-1 (PubMed:16319922).

6239:CELE T05B4.6
gene id: 6239:CELE_T05B4.6
uniprot id: O16416
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T25G12.13
gene id: 6239:CELE_T25G12.13
uniprot id: H2L0K8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE C30B5.6
gene id: 6239:CELE_C30B5.6
uniprot id: H2KZ36
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47H9C.7
gene id: 6239:CELE_Y47H9C.7
uniprot id: Q9XWD5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

6239:CELE C16D6.2
gene id: 6239:CELE_C16D6.2
uniprot id: A0A078BS36
uniprot id: A0A078BTK0
uniprot id: A0A0K3AYF5
uniprot id: O62062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

6239:CELE C32E8.6
gene id: 6239:CELE_C32E8.6
uniprot id: H2KZ58
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE K05B2.5
gene id: 6239:CELE_K05B2.5
uniprot id: H2L0E6
uniprot id: Q2L6X7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK632.4
gene id: 6239:CELE_ZK632.4
uniprot id: P34650
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

6239:CELE C30F12.6
gene id: 6239:CELE_C30F12.6
uniprot id: Q95YD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

6239:CELE M110.2
gene id: 6239:CELE_M110.2
uniprot id: Q21529
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F54D5.11
gene id: 6239:CELE_F54D5.11
uniprot id: G5EG47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

6239:CELE R04A9.7
gene id: 6239:CELE_R04A9.7
uniprot id: Q21694
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE D2030.6
gene id: 6239:CELE_D2030.6
uniprot id: P90786
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE D2030.1
gene id: 6239:CELE_D2030.1
uniprot id: P90787
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

6239:CELE C48B4.4
gene id: 6239:CELE_C48B4.4
uniprot id: P34358
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCA family.
messages: Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells.
messages: Membrane
messages: Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
messages: Ubiquitous in embryos. Expressed in larval germline precursors. Expression in larvae and adults is seen in amphid sheath cells, pharyngeal-intestinal valve and phasmid sheath cells. Low levels of expression are also seen in gonadal sheath cells.

6239:CELE F47F6.1
gene id: 6239:CELE_F47F6.1
uniprot id: Q65ZG8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed from late embryonic stage onwards (PubMed:10550049, PubMed:16300753). Shows oscillating expression levels during larval stages, with peak levels in intermolt periods and minimal levels during ecdysis (PubMed:16300753, PubMed:20843862, PubMed:22137474, PubMed:29880558). Expressed in hypodermis, vulva, intestine, muscle, neurons and somatic gonad throughout larval development, in an oscillating pattern (PubMed:16300753, PubMed:22137474). Expressed in sex myoblasts during larval stages L1, L2 and L3, in an oscillating pattern (PubMed:16300753). Expressed in gonad distal tip cells (DTC) during the L2 and L3 stages, in an oscillating pattern (PubMed:16300753).
messages: Expressed in the pharyngeal myoepithelium, the major body hypodermal syncytium and lateral seam cells from the mid L1 stage. Expression in the hypodermis rises and falls at the start and end of every molt, respectively.
messages: Mutants exhibit a delay in development characterized by a strong molting defect, resulting in a prolonged L1 stage followed by an arrest in development in the L2 stage in most animals (PubMed:25319259). There is increased expression of the heterochronic miRNAs, lin-4 and miR-48, in late L1 (PubMed:25319259). In addition, there is increased expression of the heterochronic miRNA let-7 at the L3 and L4 larval stages (PubMed:29880558). Seam cell shape and connectivity is severely abnormal during the molt stages (PubMed:22137474). Animals display a precocious alae phenotype, with the early formation of either full or partial alae in the adult cuticle (PubMed:25319259, PubMed:29880558). The precocious alae phenotype is suppressed in the double lin-42 and let-7 mutant and lin-42 and miR-48 mutant (PubMed:25319259). The quadruple lin-42, miR-48, miR-241 and let-7 mutant has a retarded phenotype at L4, with many animals having few full and partial alae or none (PubMed:25319259). The number of animals displaying a squat body statue, referred to as a dumpy phenotype, is increased, the incomplete alae formation defect is rescued and increased let-7 levels are reduced in a kin-20 RNAi-mediated knockdown mutant background (PubMed:29880558). RNAi-mediated knockdown leads to a severe hypodermal phenotype, premature execution of developmental events in vulval precursor cells, DTC and sex myoblasts (PubMed:16300753). Furthermore, seam cell terminal differentiation is only partially initiated at the L4 larval stage (PubMed:15691769). RNAi-mediated knockdown increases the survival rate and partially restores alae formation of let-7 n2853 mutants at 20 degrees Celsius (PubMed:15691769).
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing.
messages: Specifically required for maintaining the timing of larval development and molting cycle rhythms.
messages: Transcriptional repressor which interacts with the promoter region of target genes (PubMed:25032706). Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs (PubMed:16300753, PubMed:25032706, PubMed:25319259, PubMed:15691769, PubMed:29880558). Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58 (PubMed:24699545, PubMed:25032706, PubMed:25319259, PubMed:15691769, PubMed:29880558). Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells (PubMed:10550049, PubMed:21471153). Has a role in the miRNA-mediated specification of asymmetric gene expression patterns in gustatory neurons (PubMed:25032706). May also regulate genes involved in other biological processes including transport, small molecule metabolism, and growth (PubMed:25032706). Inhibits dauer formation, by antagonizing daf-12 (PubMed:20843862).

6239:CELE F59A7.3
gene id: 6239:CELE_F59A7.3
uniprot id: O16278
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y39D8A.1
gene id: 6239:CELE_Y39D8A.1
uniprot id: H2KYC1
uniprot id: H2KYC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE Y38E10A.4
gene id: 6239:CELE_Y38E10A.4
uniprot id: Q9NAK6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T27A8.3
gene id: 6239:CELE_T27A8.3
uniprot id: P50581
names: Caution
names: Similarity
messages: Belongs to the peptidase M24 family.
messages: Could be the product of a pseudogene. This sequence seems to be incomplete in both termini.

6239:CELE F07B7.3
gene id: 6239:CELE_F07B7.3
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE B0024.9
gene id: 6239:CELE_B0024.9
uniprot id: G3MU08
uniprot id: Q17424
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

6239:CELE F09F7.2
gene id: 6239:CELE_F09F7.2
uniprot id: P53014
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).

6239:CELE C34B7.3
gene id: 6239:CELE_C34B7.3
uniprot id: P90771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Membrane

6239:CELE C44B12.6
gene id: 6239:CELE_C44B12.6
uniprot id: A0A0S4XR92
uniprot id: A0A0S4XRS1
uniprot id: U4PCC9
names: Similarity
messages: Belongs to the IL-17 family.

6239:CELE Y62E10A.5
gene id: 6239:CELE_Y62E10A.5
uniprot id: Q2HQK2
uniprot id: Q9U1Y0
names: Similarity
messages: Belongs to the MGMT family.

6239:CELE F55H2.6
gene id: 6239:CELE_F55H2.6
uniprot id: P34466
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

6239:CELE M7.1
gene id: 6239:CELE_M7.1
uniprot id: P35129
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short-lived and abnormal proteins (PubMed:16628214). Plays a role in the DNA damage response (PubMed:16628214). In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms (PubMed:16628214). Required, cell autonomously, for death of the linker cell, a male-specific cell which guides the elongation of the gonad; perhaps acting as part of the ubiquitin proteasome system (UPS) and modulated by heat shock transcription factor hsf-1 (PubMed:26952214).
messages: Chromosome
messages: Cytoplasm
messages: Expressed at all stages of development (PubMed:8441382, PubMed:8670823). Expressed in most embryonic tissues and larval tissues at the early stages (PubMed:8670823). Highly expressed in neurons, pharynx, the hyperdermis and body muscles in L1, L2, L3 and dauer larvae (PubMed:8670823). From the L4 stage of larval development and in adults, expression is mainly restricted to the nervous system, but is also expressed in the pharynx and hyperdermis (PubMed:8670823). Expressed in the linker cell, a male-specific cell which guides the elongation of the gonad, about 1-2 hours before induction of linker cell death (PubMed:26952214).
messages: Expressed in the nervous system.
messages: Interacts with the brc-1-brd-1 heterodimer following ionizing irradiation.
messages: Nucleus
messages: RNAi-mediated knockdown results in reduced ubiquitination at DNA damage sites (PubMed:16628214). Inappropriate survival of male gonadal linker cell (PubMed:26952214).

6239:CELE T20F5.2
gene id: 6239:CELE_T20F5.2
uniprot id: P91477
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

6239:CELE F40F8.7
gene id: 6239:CELE_F40F8.7
uniprot id: G5EFY7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in intestinal cells from larval through to adult stages (PubMed:23911329). Expressed in neurons during L1 larval stage (PubMed:29949773).
messages: Induced by paraquat, a chemical causing production of reactive oxygen species (ROS).
messages: Interacts with ceh-60.
messages: Nucleus
messages: RNAi-mediated knockdown on a daf-2 mutant background shortens lifespan substantially, by up to 45%, but does not alter lifespan on a daf-16 mutant or wild-type background (PubMed:23911329). Knockdown activates vitellogenesis on either lin-29, rict-1 or sgk-1 mutant backgrounds, but not on daf-2 mutants (PubMed:27401555). Reduced expression of metal transporter smf-3 on an nhr-14 mutant background (PubMed:27401555). Enhanced sensitivity to P.aeruginosa infection on an nhr-14 mutant background (PubMed:31532389).
messages: Zinc finger transcription factor which acts as both a transcriptional activator and repressor (PubMed:23911329, PubMed:30956009). Binds to the promoters of genes that contain the 5'-CTTATCA-3' DNA consensus sequence in their regulatory region (PubMed:23911329, PubMed:31532389). Functions downstream of the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:23911329, PubMed:27401555). Involved in normal development, lifespan, stress response, lipid metabolism, innate immunity and exit from the developmentally arrested larval state known as dauer (PubMed:23911329, PubMed:27401555, PubMed:29949773, PubMed:31532389, PubMed:33009389). Required for stress-induced expression of hsp-90 and resistance to heat stress, perhaps as part of a systemic stress signaling pathway (PubMed:29949773). Involved in maintenance of proteostasis (PubMed:29949773). Under hypoxic stress increases lipid levels by positively regulating fatty acid synthesis via fat-7 expression (PubMed:33009389). Associates with homeobox protein ceh-60 at the promoters of some stress-responsive genes to regulate expression; may require phosphorylation for transcriptional repression activity (PubMed:30956009). Acts downstream of nhr-14 to activate transcription of intestinal metal transporter smf-3, modulating innate immunity and iron uptake (PubMed:31532389). May act downstream of the mTORC2 signaling mediated pathway (PubMed:27401555). May act in a mutually exclusive manner with the FOXO transcription factor daf-16 (PubMed:23911329, PubMed:27401555).

6239:CELE Y39E4A.3
gene id: 6239:CELE_Y39E4A.3
uniprot id: O45924
uniprot id: Q4A1S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCKDHA family.
messages: Mitochondrion matrix
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso) (PubMed:15340492).
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

6239:CELE F36A2.8
gene id: 6239:CELE_F36A2.8
uniprot id: P90861
names: Function
names: Similarity
messages: Belongs to the janus family.
messages: JanA and janB regulate somatic sex differentiation.

6239:CELE Y106G6H.8
gene id: 6239:CELE_Y106G6H.8
uniprot id: Q9U2Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

6239:CELE F08H9.8
gene id: 6239:CELE_F08H9.8
uniprot id: Q19226
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y48G10A.1
gene id: 6239:CELE_Y48G10A.1
uniprot id: G5EF86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

6239:CELE H20J04.4
gene id: 6239:CELE_H20J04.4
uniprot id: Q2WF63
uniprot id: Q9N5M1
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE F58A4.3
gene id: 6239:CELE_F58A4.3
uniprot id: P34470
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, hcp-3 and H4 assembled in one hcp-3-H4 heterotetramer and two H2A-H2B heterodimers. The hcp-3-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers (By similarity). Interacts with knl-2 (PubMed:17339379). Interacts with lin-53 (PubMed:26904949).
messages: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:10524621). Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11402065, PubMed:14522947, PubMed:16273096, PubMed:16950114, PubMed:16950115, PubMed:12080088, PubMed:15767665). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis (PubMed:23684975). Not required for chromosome segregation during meiosis (PubMed:16273096).
messages: Nucleus
messages: Present at higher lower (>95%) level than cpar-1 (at protein level).
messages: RNAi-mediated knockdown impacts chromosome segregation leading to abnormal chromatin distribution (PubMed:16950114, PubMed:17339379). Disrupts mel-28 localization to kinetochores (PubMed:16950115). Leads to cleavage furrow regression and failed cytokinesis during the second embryonic division (PubMed:23684975). RNAi-mediated knockdown abolishes the localization of hcp-6 at the centromeres of mitotic chromosomes (PubMed:12080088).
messages: centromere
messages: kinetochore

6239:CELE K01D12.4
gene id: 6239:CELE_K01D12.4
uniprot id: I2HAG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE B0213.12
gene id: 6239:CELE_B0213.12
uniprot id: O44657
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE ZK550.4
gene id: 6239:CELE_ZK550.4
uniprot id: G5EG49
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.

6239:CELE W04D2.1
gene id: 6239:CELE_W04D2.1
uniprot id: H2L2C8
uniprot id: H2L2C9
uniprot id: Q23158
uniprot id: Q9XVU8
names: Similarity
messages: Belongs to the alpha-actinin family.

6239:CELE W07B8.4
gene id: 6239:CELE_W07B8.4
uniprot id: A0A0K3AVX9
uniprot id: O16288
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y48B6A.12
gene id: 6239:CELE_Y48B6A.12
uniprot id: Q9U296
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

6239:CELE ZC477.9
gene id: 6239:CELE_ZC477.9
uniprot id: P19826
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell junction
messages: Cell membrane
messages: Expressed in adult animals.
messages: Expressed in gonadal sheath cells and the spermatheca (PubMed:17326220). Expressed in body wall muscles (PubMed:20385102).
messages: Involved in cell adhesion (PubMed:20385102). May be involved in the attachment of the actin-based microfilaments to the plasma membrane (PubMed:17326220, PubMed:31411810). Involved in ovulation (PubMed:17326220).
messages: May interact with sorb-1.
messages: RNAi-mediated knockdown causes an accumulation in the proximal gonad of endomitotic mature oocytes in 30 percent of animals (PubMed:17326220). RNAi-mediated knockdown disrupts the assembly of actin into myofibrils, and furthermore reduces the co-localization of ketn-1 and actin in early embryos (PubMed:31411810).
messages: adherens junction
messages: cytoskeleton
messages: focal adhesion

6239:CELE F22B5.10
gene id: 6239:CELE_F22B5.10
uniprot id: Q19714
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Homodimer and homotetramer.

6239:CELE T17E9.1
gene id: 6239:CELE_T17E9.1
uniprot id: P46549
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility (PubMed:23064028). Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division (PubMed:23064028). Might play a role in cell cycle progression (PubMed:23064028). In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation (PubMed:26510792). Plays a role in meiotic recombination events (PubMed:26510792). Involved in pharyngeal pumping (PubMed:11733138).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STE20 subfamily.
messages: Expressed during embryogenesis (PubMed:23064028). Expressed in adults (PubMed:11733138).
messages: Expressed in the pharynx, including the pharyngeal muscle of the metacorpus, the isthmus, and the terminal bulb; in the intestine, including the pharyngeointestinal valve between the pharynx and the intestine, a structure near the anus likely to be the anal sphincter and the excretory cell and in several ring neurons.
messages: RNAi-mediated knockdown leads to embryonic lethality (PubMed:23064028). Increased and prolonged cortical contractility leading to a more persistent pseudocleavage in surviving embryos (PubMed:23064028). Decrease in rho-1 anterior cortex localization and increase in posterior cortex localization, leading to a loss of asymmetric rho-1 cortex localization during early embryonic cell division (PubMed:23064028). Increased cortical nmy-2 network between the foci, suggesting that the enhanced contractions are due to increased actomyosin contractility (PubMed:23064028). Reduction in the size of the anterior cortex and increase in the size of the posterior cortex during polarity establishment in the early embryo (PubMed:23064028). Leads to a delay in embryonic cell cycle progression (PubMed:23064028). Double RNAi-mediated knockdown with rho-1 results in loss of cortical contractility (PubMed:23064028).
messages: cell cortex
messages: cytoskeleton

6239:CELE F33H1.2
gene id: 6239:CELE_F33H1.2
uniprot id: P17331
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in Caenorhabditis elegans.

6239:CELE R12C12.3
gene id: 6239:CELE_R12C12.3
uniprot id: Q21957
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C56E10.4
gene id: 6239:CELE_C56E10.4
uniprot id: B3WFU1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y111B2A.17
gene id: 6239:CELE_Y111B2A.17
uniprot id: Q9NEW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE Y74C9A.3
gene id: 6239:CELE_Y74C9A.3
uniprot id: Q9N4D9
names: Function
names: Similarity
names: Tissue Specificity
messages: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.
messages: Belongs to the methyltransferase superfamily. NTM1 family.
messages: Expressed in uterine cells and PVT neurons of the tail.

6239:CELE F23F1.6
gene id: 6239:CELE_F23F1.6
uniprot id: O17069
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

6239:CELE K07A1.6
gene id: 6239:CELE_K07A1.6
uniprot id: P90911
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F42A10.8
gene id: 6239:CELE_F42A10.8
uniprot id: P98061
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE K07B1.2
gene id: 6239:CELE_K07B1.2
uniprot id: O01884
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE C34D1.1
gene id: 6239:CELE_C34D1.1
uniprot id: G5EEJ1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DMRT family.
messages: Decreased response to nose touch, but normal motor and sensory behaviors and normal levels of glutamate receptor glr-1 (PubMed:33665029). Small but significant decrease in response to high osmolarity (PubMed:33665029). Decreased reversal responses to direct stimulation of the polymodal sensory neuron ASH as compared to wild type (PubMed:33665029). Defects in male mating behavior; reduced efficiency in locating vulva of partner (PubMed:27144354). Alterations in AVG interneuron synaptic wiring in a dmd-5 mutant background (PubMed:27144354).
messages: Dimorphically expressed in the dimorphically connected interneuron AVG; expression is observed in the AVG in males, but not in hermaphrodites.
messages: Nucleus
messages: Transcription factor (By similarity). Plays a role in neuronal signaling in polymodal sensory neuron ASH, downstream of sensory receptor activation (PubMed:33665029). Required for maintenance of AVG synapses (PubMed:27144354).

6239:CELE F35G12.7
gene id: 6239:CELE_F35G12.7
uniprot id: Q20051
names: Similarity
messages: Belongs to the CutA family.

6239:CELE F42G8.3
gene id: 6239:CELE_F42G8.3
uniprot id: Q8MXI4
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by phosphorylation on threonine and tyrosine. Inhibited by pyridinyl-imidazole related compounds.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-222 and Tyr-224, which activates the enzyme.
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

6239:CELE Y73B6BL.42
gene id: 6239:CELE_Y73B6BL.42
uniprot id: Q65XS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE F14F11.1
gene id: 6239:CELE_F14F11.1
uniprot id: G5EC00
uniprot id: G5ECD2
uniprot id: Q8I4L1
uniprot id: Q8I4L2
uniprot id: Q8I4L3
uniprot id: Q8I4L4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK637.7
gene id: 6239:CELE_ZK637.7
uniprot id: P30630
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-9 family.
messages: Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059). Interacts with zft-11; the interaction is required to suppress the activation of non-neuronal genes in neurons (PubMed:31386623).
messages: Decreased protein levels of DRM complex components including lin-37, lin-52 and lin-54 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514). RNAi-mediated knockdown in a ced-1 mutant background results in reduced somatic cell apoptosis (PubMed:27650246).
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein (PubMed:16678779, PubMed:17075059). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:17075059). Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad (PubMed:10974557). In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623).

6239:CELE F32A7.6
gene id: 6239:CELE_F32A7.6
uniprot id: P91863
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Probable serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:16945111). May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:16945111). In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ) (PubMed:11804572). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP) (PubMed:2323555, PubMed:11804572, PubMed:18852466, PubMed:25849533). Probably by regulating DMP, required for fatty acid uptake by intestinal cells and therefore regulates the levels of triglycerides in the intestine (PubMed:25849533). Plays a role in locomotion (PubMed:11804572).
messages: RNAi-mediated knockdown causes a reduction in fatty acid uptake (PubMed:25849533). RNAi-mediated knockdown in the intestine causes a severe defect in the expulsion step of the defecation cycle (PubMed:18852466).
messages: Secreted

6239:CELE C14B9.2
gene id: 6239:CELE_C14B9.2
uniprot id: P34329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

6239:CELE H01A20.1
gene id: 6239:CELE_H01A20.1
uniprot id: Q9XTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE W03H9.4
gene id: 6239:CELE_W03H9.4
uniprot id: G5EG14
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CACTIN family.
messages: Cytoplasm
messages: Expressed in migrating distal tip cells throughout larval development (at protein level).
messages: Expressed in pharynx, intestine, vulva and spermatheca (at protein level).
messages: Nucleus
messages: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Plays a role during early embryonic development (PubMed:20188721). Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis (PubMed:20188721).

6239:CELE Y110A7A.13
gene id: 6239:CELE_Y110A7A.13
uniprot id: G5EEI8
names: Disruption Phenotype
names: Function
messages: RNAi-mediated knockdown results in reduced fertility and in high levels of embryonic lethality with none of the unhatched embryos reaching the comma stage of development (PubMed:10571178). Among the 40% of embryos that hatch, 98% reach adulthood, but have a reduced brood size, and the remaining 2% do not survive beyond the L1 larval stage (PubMed:10571178). Surviving adults have defects in vulval development, whereby 3-5% have a protruding vulva (Pvl) phenotype and 1% have a multivulva (Mvl) phenotype (PubMed:10571178). Occasionally, some adults have one missing gonadal arm, but many adults have defects in the organization of the proximal arm of the gonad, which are filled with smaller cells instead of full sized oocytes (PubMed:10571178). RNAi-mediated knockdown results in reduced plasma membrane localization and increased intracellular accumulation of let-23 in vulval precursor cells P6.p and their descendants (PubMed:32053105). RNAi-mediated knockdown does not affect the membrane localization of lin-12, lin-18 or pat-3 (PubMed:32053105). RNAi-mediated knockdown in vulval precursor cells results in the intracellular accumulation of let-23 in 31% of cases (PubMed:32053105).
messages: Regulates centrosome duplication (By similarity). Controls the secretion of the tyrosine kinase receptor let-23/EGFR from the endoplasmic reticulum and is required for the localization of let-23/EGFR to the plasma membrane of vulval precursor cells (PubMed:32053105). It thus plays a role in positively regulating let/EGFR signaling, and anchor cell and vulval precursor cell alignment (PubMed:32053105). Plays a role in vulval development and morphogenesis (PubMed:10571178, PubMed:32053105).

6239:CELE C18G1.2
gene id: 6239:CELE_C18G1.2
uniprot id: O61924
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed highly during embryogenesis. Expressed in the endoderm in cells of the gut lineage beginning at the 2E cell stage (endodermal cell stage) of embryogenesis through to adulthood.
messages: Induced by P.aeruginosa infection.
messages: No obvious phenotype (PubMed:20807527). RNAi-mediated knockdown results in no obvious phenotype (PubMed:18448117). Following infection with P.aeruginosa, RNAi-mediated knockdown results in reduced survival and slight intestinal distension (PubMed:21168435). Double mutation with elt-2 results in arrest at the L1 stage of larval development, reduced expression of gut-specific genes and a severe disruption to normal gut differentiation with the absence of birefringent and rhabditin granules, which are characteristic of normal gut differentiation, largely at the regions of the cell that interface with the pharyngeal and rectal valves (PubMed:20807527). These mutants also have essentially no gut lumen, with only infrequent patches of lumen and brush border in few animals, and reduced gut epithelialization as indicated by reduced expression of epithelial markers erm-1b, itx-1 and ajm-1 (PubMed:20807527).
messages: Nucleus
messages: Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:26700680). Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527, PubMed:24257624). May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa (PubMed:21168435).

6239:CELE C52D10.11
gene id: 6239:CELE_C52D10.11
uniprot id: A3QM96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

6239:CELE B0213.15
gene id: 6239:CELE_B0213.15
uniprot id: A0A168H3M4
uniprot id: H2KY68
uniprot id: H2KY69
uniprot id: Q2MGF0
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F10D2.11
gene id: 6239:CELE_F10D2.11
uniprot id: O16922
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F56F3.5
gene id: 6239:CELE_F56F3.5
uniprot id: P48154
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Cytoplasm

6239:CELE ZC262.5
gene id: 6239:CELE_ZC262.5
uniprot id: P34539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

6239:CELE K04B12.3
gene id: 6239:CELE_K04B12.3
uniprot id: O62301
uniprot id: U4PBA4
uniprot id: U4PEH8
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Defects in nonsense-mediated mRNA decay (NMD).
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes.

6239:CELE B0273.2
gene id: 6239:CELE_B0273.2
uniprot id: O44169
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: Puf-6 and puf-7 are >98% identical on both nucleotide and protein sequence level. Experimental approaches often do not distinguish between the two genes, which are collectively referred to as puf6/7 and are considered to be functionally redundant.
messages: RNA-binding protein that binds to the consensus sequence 5'-CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.
messages: Simultaneous knockdown of puf-6 and puf-7 results in ectopic primordial germ cells (PGCs) outside the somatic gonads, premature PGC proliferation in L1 larvae and germ cell death. Does not affect germline development in adult hermaphrodites. Disruption with puf-5 and puf-6 results in abnormally small oocytes, disorganization of oocyte nuclei and cells, inefficient yolk uptake by oocytes, embryonic arrest with impaired eggshell formation and cytokinesis defects, impaired repression of glp-1 in late oogenesis, and mislocalization of rme-2 to the cytoplasm instead of the plasma membrane.

6239:CELE T01E8.5
gene id: 6239:CELE_T01E8.5
uniprot id: G5EG51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NRDE2 family.
messages: Interacts with nrde-3.
messages: Nucleus
messages: Nucleus speckle
messages: Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs-mediated silencing in nuclei (PubMed:20543824). Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription (PubMed:20543824). Required for exogenous RNAi-induced H3K27 methylation (PubMed:26365259).

6239:CELE C52D10.7
gene id: 6239:CELE_C52D10.7
uniprot id: G5EFA9
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE Y54E2A.2
gene id: 6239:CELE_Y54E2A.2
uniprot id: Q9XWJ1
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the SMG9 family.
messages: Defects in nonsense-mediated decay (NMD).
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes.

6239:CELE R07D5.1
gene id: 6239:CELE_R07D5.1
uniprot id: C8JQR7
uniprot id: Q03412
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Heterooligomer of unc-7 and unc-9.
messages: In hermaphrodites, expressed in all premotor and motor neurons, and in tail neurons (PubMed:26156999). In males, expressed in the anal depressor, gubernacular erector, gubernacular retractor and anterior oblique muscles, SPC, PCA, PCB, HOA, ray, head ganglion and ventral cord neurons (PubMed:26156999).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Present in all developmental stages but most abundant in L1-L3 larvae.
messages: Restores pharyngeal pumping but not impaired locomotion in 33 percent of animals overexpressing lin-3.
messages: Structural component of the gap junctions (By similarity). Required for coordinated locomotion (PubMed:7681023). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142). Plays a role in regulating male mating behavior by positively regulating inhibitory neuronal signaling transduction between chemosensory and mechanosensory neurons, and thus ensuring spicule insertion attempts are confined to the hermaphrodite vulva during copulation (PubMed:26156999).
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE F39D8.4
gene id: 6239:CELE_F39D8.4
uniprot id: Q20191
names: Cofactor
names: Function
names: Sequence Caution
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Deletion of several nucleotides that changes the frame.
messages: Metalloprotease.
messages: Secreted

6239:CELE F13H10.4
gene id: 6239:CELE_F13H10.4
uniprot id: Q19426
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically.
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knockdown reduces lifespan to less than half of that of controls. Reduced paucimannose and complex-type glycans and increased glucosylated oligomannose glycans and fucosylated N-glycans. Chronic endoplasmic reticulum stress response is believed to be due to the accumulation of triglucosylated free oligosaccharides as a result of impaired glycan processing.

6239:CELE Y66H1A.6
gene id: 6239:CELE_Y66H1A.6
uniprot id: H2L0I7
uniprot id: U4PBY2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE F38H12.3
gene id: 6239:CELE_F38H12.3
uniprot id: O16346
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08E3.1
gene id: 6239:CELE_K08E3.1
uniprot id: Q9XUS8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F40F4.2
gene id: 6239:CELE_F40F4.2
uniprot id: Q20224
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell.
messages: Secreted

6239:CELE ZK353.1
gene id: 6239:CELE_ZK353.1
uniprot id: P34624
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal localization of synaptic vesicle components and active zone proteins in the cell body and in the dentrite of DA9 motor neuron (PubMed:20510931). In L4 mutants, incomplete elimination of ventral rab-3-positive synaptic vesicles and small reduction in the formation of dorsal rab-3-positive synaptic vesicles in DD motor neurons, although formation of ventral synapses at the L1 stage is normal (PubMed:21609829). No other phenotype except a slightly smaller progeny size (PubMed:20510931).
messages: Belongs to the cyclin family.
messages: Cytoplasm
messages: In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons (PubMed:20510931). Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures (PubMed:21609829). May activate cdk-5 (PubMed:20510931).
messages: Interacts with pct-1; the interaction is required to activate pct-1.
messages: axon
messages: dendrite

6239:CELE Y32H12A.2
gene id: 6239:CELE_Y32H12A.2
uniprot id: C2BR94
uniprot id: H2L0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

6239:CELE F09C12.2
gene id: 6239:CELE_F09C12.2
uniprot id: Q19243
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

6239:CELE ZC328.1
gene id: 6239:CELE_ZC328.1
uniprot id: O02051
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with vps-39.
messages: Involved in cuticle formation and ensures cuticle shedding during larval development (PubMed:19357781). Plays a role in maintaining the hypodermis (PubMed:19357781). In association with vps-39, may play a role in vesicle tethering (PubMed:19357781).
messages: RNAi-mediated knockdown results in a squat body statue referred to as a dumpy phenotype, uncoordinated movements, and while animals can move in a sinusoidal manner, they cannot progress forward or backward, (referred to as a skiddy phenotype) (PubMed:19357781). Animals also display cuticle formation defects where the cuticle blisters at the point where the outer layers dissociate from the body, and furthermore the cuticle fails to shed and wraps tightly around the body (PubMed:19357781). In 10% of animals, the cuticle tapers in the posterior region of the body (PubMed:19357781). RNAi-mediated knockdown also results the formation of vesicle-like structures in the hypodermis, thickening of the hypodermis and in its degeneration, and as a consequence as hermaphrodites reach gravidity, the vulva protrudes and eventually ruptures, leading to death (PubMed:19357781). In addition, animals display seam cell fusion and function defects resulting from bifurcation of alae (PubMed:19357781). RNAi-mediated knockdown in males results in sensory ray defects where the rays fail to fully extend, and a reduced sized cuticular fan (PubMed:19357781).
messages: Temporally expressed in embryos and larvae (PubMed:19357781). Expression peaks prior to each larval molt (PubMed:19357781). In L4 larvae, expressed in the hypodermis, in the vulval and anal epithelium, in the excretory pore, the seam cells and at the seam cell boundary (PubMed:19357781). Not expressed in adults (PubMed:19357781).

6239:CELE F59D8.2
gene id: 6239:CELE_F59D8.2
uniprot id: P18947
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the intestine of adult hermaphrodites.
messages: High sequence similarity with other vitellogenin genes means that assigning functions to individual proteins is difficult; authors sometimes refer to VITs or vitellogenins.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). Together with other vitellogenins, may play a role in modulating life-span, acting via induction of autophagy and lysosomal lipolysis (PubMed:26671266).
messages: Secreted
messages: Simultaneous RNAi-mediated knockdown of vitellogenins vit-1, vit-2, vit-3, vit-4 and vit-5 increases life span, causes accumulation of neutral lipid and an increase in lgg-1 foci in the proximal intestine; however, does not affect fertility or pharyngeal pumping rates (PubMed:26671266). Expression of transcription factors pha-4 and daf-16 are increased (PubMed:26671266).

6239:CELE ZC84.1
gene id: 6239:CELE_ZC84.1
uniprot id: Q03610
names: Subcellular Location Annotation
messages: Secreted

6239:CELE K09A11.4
gene id: 6239:CELE_K09A11.4
uniprot id: Q27507
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE K02D7.5
gene id: 6239:CELE_K02D7.5
uniprot id: O45102
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Mediates both low-affinity uptake and efflux of sugar across the membrane.

6239:CELE Y16B4A.2
gene id: 6239:CELE_Y16B4A.2
uniprot id: K8ESM2
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE F22B7.13
gene id: 6239:CELE_F22B7.13
uniprot id: Q95QJ7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122).
messages: Interacts with gpr-1, lin-5 and GDP-bound goa-1.
messages: Simultaneous RNAi-mediated knockdown of both gpr-1 and gpr-2 causes, in the 1-cell embryo, a decrease in nuclear and spindle movements during prophase, reduced asymmetric spindle elongation during anaphase and mispositioning of nuclei after cell division.
messages: cell cortex
messages: spindle

6239:CELE F18G5.4
gene id: 6239:CELE_F18G5.4
uniprot id: P54245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Possible acetylcholine receptor.
messages: Postsynaptic cell membrane

6239:CELE E03A3.3
gene id: 6239:CELE_E03A3.3
uniprot id: Q27489
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Could be the product of a pseudogene.
messages: Nucleus
messages: Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).
messages: Worms exhibit slow postembryonic growth.

6239:CELE C44B7.4
gene id: 6239:CELE_C44B7.4
uniprot id: Q18593
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CALHM family.
messages: Cell membrane
messages: Expressed in head and body wall muscles, IL2, ASG, ASI, ASJ, PHA and PHB sensory neurons, and spermatheca.
messages: Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion.
messages: Uncoordinated locomotion with mutants showing reduced forward velocity, muscle force and power production.

6239:CELE B0280.9
gene id: 6239:CELE_B0280.9
uniprot id: P42000
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

6239:CELE F17C8.2
gene id: 6239:CELE_F17C8.2
uniprot id: Q19528
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C25A1.1
gene id: 6239:CELE_C25A1.1
uniprot id: O17594
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F53C3.12
gene id: 6239:CELE_F53C3.12
uniprot id: Q9TXT9
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

6239:CELE F58B3.3
gene id: 6239:CELE_F58B3.3
uniprot id: Q20968
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

6239:CELE Y54G11A.17
gene id: 6239:CELE_Y54G11A.17
uniprot id: C0Z3L6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

6239:CELE F56D2.6
gene id: 6239:CELE_F56D2.6
uniprot id: Q20875
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
messages: Nucleus
messages: Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.

6239:CELE R11A5.7
gene id: 6239:CELE_R11A5.7
uniprot id: Q9XU75
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Cytoplasmic vesicle
messages: Expressed from the 3-fold embryonic stage to young adult and at the larval stage in hypodermal and intestinal cells.
messages: Localizes in stripes along the cuticle.
messages: May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19.
messages: RNAi-mediated knockdown results in a slightly shorter and stouter body.
messages: Secreted
messages: The ShKT and Thr-rich domains are required for body morphogenesis.

6239:CELE K01A2.7
gene id: 6239:CELE_K01A2.7
uniprot id: Q9TZ57
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE M110.7
gene id: 6239:CELE_M110.7
uniprot id: Q21534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Membrane

6239:CELE ZK455.4
gene id: 6239:CELE_ZK455.4
uniprot id: Q23498
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Preferentially expressed in postembryonic development.
messages: Requires Zn(2+) to be fully active.
messages: Secreted
messages: Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin (N-acyl-sphingoid-1-phosphocholine) to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH. Displays its enzymatic activity when secreted. May play distinct roles in signaling.
messages: There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinases have been found in worms.

6239:CELE K08B5.1
gene id: 6239:CELE_K08B5.1
uniprot id: Q21309
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48C3A.3
gene id: 6239:CELE_Y48C3A.3
uniprot id: Q9NAG5
names: Similarity
messages: Belongs to the FAX family.

6239:CELE K02G10.1
gene id: 6239:CELE_K02G10.1
uniprot id: Q21161
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F52H3.6
gene id: 6239:CELE_F52H3.6
uniprot id: Q27501
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE C08E8.2
gene id: 6239:CELE_C08E8.2
uniprot id: O62040
names: Similarity
messages: Belongs to the strictosidine synthase family.

6239:CELE ZK1058.6
gene id: 6239:CELE_ZK1058.6
uniprot id: Q23384
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

6239:CELE C15A11.6
gene id: 6239:CELE_C15A11.6
uniprot id: Q93207
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F26G1.1
gene id: 6239:CELE_F26G1.1
uniprot id: Q19833
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

6239:CELE F32D1.2
gene id: 6239:CELE_F32D1.2
uniprot id: O16298
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

6239:CELE W02D3.6
gene id: 6239:CELE_W02D3.6
uniprot id: O01813
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE F54B11.2
gene id: 6239:CELE_F54B11.2
uniprot id: Q20739
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F23H11.2
gene id: 6239:CELE_F23H11.2
uniprot id: O01914
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds.
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).
messages: nucleolus

6239:CELE R74.5
gene id: 6239:CELE_R74.5
uniprot id: G5EEW7
uniprot id: M1ZJT7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C10G8.1
gene id: 6239:CELE_C10G8.1
uniprot id: Q94168
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE JC8.6
gene id: 6239:CELE_JC8.6
uniprot id: Q95QD7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-54 family.
messages: Chromosome
messages: Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1.
messages: Decreased protein levels of DRM complex components including lin-9 and lin-52 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514). RNAi-mediated knockdown in a ced-1 mutant background results in reduced somatic cell apoptosis (PubMed:27650246).
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription.
messages: The CRC domain mediates DNA-binding. It contains two CXC subdomains (joined by a flexible linker) which are both required for efficient association with target DNA. Each CXC subdomain coordinates three Zn(2+) ions.
messages: Widely expressed. Present in most cells from the embryo through the adulthood.

6239:CELE C41C4.7
gene id: 6239:CELE_C41C4.7
uniprot id: Q09500
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells (PubMed:18351800).
messages: Lysosome membrane
messages: phagosome

6239:CELE Y44E3B.1
gene id: 6239:CELE_Y44E3B.1
uniprot id: H2L0N3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus
messages: RNAi-mediated knockdown decreases survival upon infection with P.aeruginosa.
messages: Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Involved in responding to mitochondrial damage (PubMed:28662060). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:28662060).

6239:CELE F45G2.6
gene id: 6239:CELE_F45G2.6
uniprot id: G5EG80
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE R07B1.3
gene id: 6239:CELE_R07B1.3
uniprot id: Q09606
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Membrane

6239:CELE T02C12.2
gene id: 6239:CELE_T02C12.2
uniprot id: Q22092
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6239:CELE Y45F10B.14
gene id: 6239:CELE_Y45F10B.14
uniprot id: Q9NAH9
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE ZK1010.2
gene id: 6239:CELE_ZK1010.2
uniprot id: G5EEZ0
names: Similarity
messages: Belongs to the RMD1/sif2 family.

6239:CELE C47G2.4
gene id: 6239:CELE_C47G2.4
uniprot id: Q18695
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family.
messages: Cell membrane
messages: May associate with G-protein coupled receptors and regulate downstream signaling pathways.

6239:CELE C40D2.4
gene id: 6239:CELE_C40D2.4
uniprot id: O76560
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE D2013.5
gene id: 6239:CELE_D2013.5
uniprot id: Q18965
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

6239:CELE W02D3.3
gene id: 6239:CELE_W02D3.3
uniprot id: O01811
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the paraoxonase family.
messages: Cell membrane
messages: Component of a non-voltage-gated amiloride-sensitive cation channel complex (also called the degenerin channel complex) composed of at least the mec-2, mec-4, mec-6 and mec-10 subunits; the complex mediates mechanotransduction in touch cells (PubMed:12478294). Interacts with mec-2, mec-4 and mec-10 (PubMed:12478294).
messages: Expressed in neurons including the six touch receptors, ventral cord motor neurons, HSN, PVD, PVC, IL1, and several neurons near the nerve ring, in the anal ganglion and in the male tail sensory rays, in muscles including the body wall, vulval, intestinal, anal depressor and sphincter muscles, and in the excretory canal.
messages: Glycosylated.
messages: Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity) (PubMed:12478294). Interacts with degenerin channel proteins and stabilizes the channel (PubMed:12478294). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:12478294, PubMed:12385749).
messages: axon

6239:CELE Y42A5A.1
gene id: 6239:CELE_Y42A5A.1
uniprot id: Q9U2H2
names: Similarity
messages: Belongs to the peptidase M1 family.

6239:CELE F55A12.4
gene id: 6239:CELE_F55A12.4
uniprot id: O01758
uniprot id: Q86NJ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F48B9.4
gene id: 6239:CELE_F48B9.4
uniprot id: G5EGC3
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Delay in the timing of the reproductive peak of egg-laying.
messages: Expressed in the interneurons BDUL/R, AVG, AIML/R, RIS, AVD and PVT, the chemosensory neuron pairs PHA and PHB, the motor neurons RID and RIML/R, the sensory neurons AQR and PQR, and in the PVPL/R interneurons (PubMed:19686386). Also expressed in rectal gland cells rectD and rectVL/R, the intestino-rectal valve cells virL/R and three posterior arcade cells in the head (PubMed:19686386).
messages: Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor (PubMed:18390545). May not signal through isoform c of pdfr-1 (PubMed:18390545). Involved in locomotion; may play a role in circadian rhythms of locomotor activity (PubMed:18390545, PubMed:22579613, PubMed:26113231). Modulator of egg-laying (PubMed:22579613).

6239:CELE Y67A6A.2
gene id: 6239:CELE_Y67A6A.2
uniprot id: O02279
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed from embryo to adult in the pharynx and intestine.
messages: Nucleus
messages: Orphan nuclear hormone receptor (PubMed:23935515). Required for metabolic and physiologic responses associated with dietary-restriction-induced longevity (PubMed:23935515). Modulates triglyceride and lipid metabolism and autophagy, associated with dietary-restriction, probably acting via regulation of transcription of target genes (PubMed:23935515).
messages: RNAi-mediated knockdown suppresses the longevity caused by an eat-2 mutant background.
messages: Widely expressed at a low level in many tissues including the pharynx, sensory neurons, intestine, spermatheca, hypodermis, and excretory cell.

6239:CELE ZK938.1
gene id: 6239:CELE_ZK938.1
uniprot id: G5ECL6
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F33C8.3
gene id: 6239:CELE_F33C8.3
uniprot id: Q19983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE Y116A8C.14
gene id: 6239:CELE_Y116A8C.14
uniprot id: A0A0K3AV34
uniprot id: Q9U2S3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48E1B.14
gene id: 6239:CELE_Y48E1B.14
uniprot id: G5EF63
names: Similarity
messages: Belongs to the sorting nexin family.

6239:CELE C37H5.6
gene id: 6239:CELE_C37H5.6
uniprot id: P91134
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

6239:CELE F17A2.12
gene id: 6239:CELE_F17A2.12
uniprot id: Q19509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F07B7.5
gene id: 6239:CELE_F07B7.5
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T19C4.3
gene id: 6239:CELE_T19C4.3
uniprot id: Q22568
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE Y51H4A.9
gene id: 6239:CELE_Y51H4A.9
uniprot id: Q9NAE0
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y49E10.19
gene id: 6239:CELE_Y49E10.19
uniprot id: Q9XTT4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cleavage furrow
messages: Enriched in embryos, where it localizes predominantly to cortical regions and the cytokinetic furrow in telophase.
messages: Midbody
messages: RNAi-mediated knockdown of the protein causes 100% embryonic lethality. Abnormal polar body extrusion with large and unstable polar bodies that often fuse with the oocyte. Failure of contractile ring to transform from a disk to a tube during meiosis. Ventral enclosure defects and failure of neuroblasts to complete cytokinesis. Aberrant microtubule-directed cortical myosin polarization.
messages: Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Promotes astral microtubule-directed cortical myosin polarization and cleavage furrow ingression. Regulates neuroblast cytokinesis during mid- to late-embryogenesis and is required for ventral enclosure.
messages: Strongly expressed in dividing neuroblasts under the ventral epidermal cells during ventral enclosure.
messages: cell cortex
messages: cytoskeleton
messages: spindle

6239:CELE C50C3.8
gene id: 6239:CELE_C50C3.8
uniprot id: P34371
names: Function
names: Subunit
messages: Interacts with cul-3.
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

6239:CELE K05F1.7
gene id: 6239:CELE_K05F1.7
uniprot id: Q21244
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F30H5.1
gene id: 6239:CELE_F30H5.1
uniprot id: G5EG62
names: Subcellular Location Annotation
messages: perinuclear region

6239:CELE Y51H7C.6
gene id: 6239:CELE_Y51H7C.6
uniprot id: Q95XZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG4 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi function.

6239:CELE F56G4.5
gene id: 6239:CELE_F56G4.5
uniprot id: Q9TW67
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Double knockout with rpt-5 RNAi results in failed expression of the proteasomal subunit rpt-3.
messages: Endoplasmic reticulum
messages: Inhibited by Zn(2+) and z-VAD-fmk (caspase inhibitor) but unaffected by EDTA.
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation (PubMed:17509531, PubMed:17522090). Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp (PubMed:17522090). Prefers proteins containing high-mannose over those bearing complex type oligosaccharides (PubMed:17522090). Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins (PubMed:17509531). Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (PubMed:17509531). Also displays oxidoreductase (thioredoxin) activity (PubMed:17509531, PubMed:17522090). Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction (PubMed:27528192).

6239:CELE F27D4.4
gene id: 6239:CELE_F27D4.4
uniprot id: Q93618
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

6239:CELE Y110A7A.6
gene id: 6239:CELE_Y110A7A.6
uniprot id: Q95Y85
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

6239:CELE F37F2.3
gene id: 6239:CELE_F37F2.3
uniprot id: O61750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Homodimer.

6239:CELE W01B6.7
gene id: 6239:CELE_W01B6.7
uniprot id: P17656
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Low level expression from embryos at comma stage to adult; maximal level in dauer larvae.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
messages: Syncytial dorsal and ventral epidermis.

6239:CELE C49G7.8
gene id: 6239:CELE_C49G7.8
uniprot id: O16220
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F14B6.6
gene id: 6239:CELE_F14B6.6
uniprot id: O62165
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C25G4.2
gene id: 6239:CELE_C25G4.2
uniprot id: Q18169
names: Similarity
messages: Belongs to the LovG family.

6239:CELE T22D1.3
gene id: 6239:CELE_T22D1.3
uniprot id: Q9GZH3
uniprot id: V6CLC6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

6239:CELE T05H4.5
gene id: 6239:CELE_T05H4.5
uniprot id: O16521
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

6239:CELE K08B4.4
gene id: 6239:CELE_K08B4.4
uniprot id: Q9TYY4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F14D7.6
gene id: 6239:CELE_F14D7.6
uniprot id: E0AHB9
uniprot id: E0AHC0
uniprot id: L8E6P0
uniprot id: Q19453
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47G6A.5
gene id: 6239:CELE_Y47G6A.5
uniprot id: Q8IAA6
uniprot id: Q9N3S5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE K11C4.3
gene id: 6239:CELE_K11C4.3
uniprot id: E0AHA7
uniprot id: G5EG85
uniprot id: Q9U9J8
uniprot id: S6FN00
names: Similarity
messages: Belongs to the spectrin family.

6239:CELE Y50E8A.4
gene id: 6239:CELE_Y50E8A.4
uniprot id: Q25AR8
uniprot id: Q8I4C9
uniprot id: Q9U277
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

6239:CELE Y54E10A.11
gene id: 6239:CELE_Y54E10A.11
uniprot id: Q65XX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC), composed of at least the E3 ubiquitin ligase ltn1 and nemf. The complex probably also contains tcf25 as well as vcp/p97 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.
messages: cytosol

6239:CELE C01G10.8
gene id: 6239:CELE_C01G10.8
uniprot id: Q93168
names: Similarity
messages: Belongs to the AHA1 family.

6239:CELE F58G11.6
gene id: 6239:CELE_F58G11.6
uniprot id: Q9XVL8
names: Similarity
messages: Belongs to the CCZ1 family.

6239:CELE Y51A2D.9
gene id: 6239:CELE_Y51A2D.9
uniprot id: H2KMI9
uniprot id: Q9XXR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T27B1.1
gene id: 6239:CELE_T27B1.1
uniprot id: Q22830
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IFT172 family.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for the maintenance and formation of chemosensory cilia that detect chemosensory cues (PubMed:10545497).
messages: Expressed in amphid and phasmid chemosensory neurons, where it appears to concentrate at the base of the transition zones, which correspond to the basal bodies of motile and sensory cilia. Moves in the retrograde direction along cilia and dendrites, suggesting that it is retrieved from the distal endings of the cilia by a retrograde transport pathway that moves it along cilia and then dendrites, back to the neuronal cell body.
messages: Worms display defects in ciliary structure resulting in defects in ability and osmotic avoidance behavior.
messages: cilium

6239:CELE ZC168.1
gene id: 6239:CELE_ZC168.1
uniprot id: G5ECW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE B0035.8
gene id: 6239:CELE_B0035.8
uniprot id: Q27876
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE W10D5.3
gene id: 6239:CELE_W10D5.3
uniprot id: Q94361
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PIAS family.
messages: Functions as an E3-type smo-1 ligase (PubMed:15654100, PubMed:16701625, PubMed:16549501, PubMed:25475837). Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment (PubMed:25475837). In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation (PubMed:15654100). In embryos, plays a role in determining telomere localization in the nucleus (PubMed:24297748).
messages: May interact with gex-3.
messages: RNAi-mediated knockdown abolishes metaphase and spindle midzone-specific smo-1 conjugation during the first embryonic mitotic division. RNAi-mediated knockdown disrupts the anchoring of telomeres to the nuclear envelope in embryos, but not in muscle nuclei (PubMed:24297748). RNAi-mediated knockdown results in ectopic tbx-2 expression in seam cells, the gut and in the syncytial hypodermis (PubMed:25873636).

6239:CELE B0395.3
gene id: 6239:CELE_B0395.3
uniprot id: Q17499
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE F11D5.3
gene id: 6239:CELE_F11D5.3
uniprot id: Q95ZV7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated on tyrosine residues.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Expressed in some neurons in head and tail, some motoneurons in ventral nerve cord, in PVP interneurons, seam cells, rectal gland cells, vulva cells and some non-neuronal cells in the tail (PubMed:23147028). Expressed in D-type motor neurons (PubMed:27984580).
messages: Expression begins during late gastrulation in seam cells and in few head neurons.
messages: Interacts with shc-1.
messages: N-glycosylation at Asn-141 is required for axon regeneration after injury but is dispensable for kinase activity and axon localization.
messages: Perikaryon
messages: Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development (PubMed:23147028). Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons (PubMed:27984580, PubMed:31371405). May mediate axon regeneration in association with the collagen emb-9 (PubMed:27984580).
messages: Viable. Normal morphology of D-type motor neurons, but 24 hours following injury of D-type motor neurons there is reduced axon regeneration. Double knockout with ddr-1 results in a more enhanced axon regeneration defect of D-type motor neurons as compared to the svh-4 and ddr-1 single mutants.
messages: axon

6239:CELE C09F9.3
gene id: 6239:CELE_C09F9.3
uniprot id: B0M0N9
uniprot id: B6VQ90
uniprot id: H2L2H2
uniprot id: U4PRW7
names: Similarity
messages: Belongs to the glutaminase family.

6239:CELE C17F4.8
gene id: 6239:CELE_C17F4.8
uniprot id: Q965M5
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE C02B10.2
gene id: 6239:CELE_C02B10.2
uniprot id: O44445
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNAPIN family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1. Interacts with dsbn-1.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.

6239:CELE C09D1.1
gene id: 6239:CELE_C09D1.1
uniprot id: O01761
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Expressed in body-wall, pharyngeal muscles and a few muscle cells of the tail (at protein level) (PubMed:8603916, PubMed:18337465, PubMed:19244614, PubMed:22621901, PubMed:22768340, PubMed:23283987, PubMed:27009202). Expressed in gonadal myoepithelial sheath cells (at protein level) (PubMed:17326220). Isoform c: Expressed in body wall and vulval muscles but not in pharyngeal muscles (PubMed:15313609). Isoform d: Specifically expressed in vulval, intestinal, anal depressor and anal sphincter muscles (PubMed:15313609).
messages: Expressed in embryos (PubMed:23283987). Isoform a: Expressed in embryo, throughout larval development and in adults (PubMed:15313609). Isoform b: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609). Isoform c: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609). Isoform d: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).
messages: In contrast to obscurins in other species, unlikely to have serine/threonine kinase activity as both protein kinase domains are predicted to be catalytically inactive. The Lys residue involved in ATP binding is not conserved in both kinase domains.
messages: M line
messages: May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and protein kinase domain 1 or C-terminus of the interkinase region) with lim-9 (via LIM zinc-binding domain) (PubMed:19244614). May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and kinase protein domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and kinase protein domain 2) with scpl-1 isoforms a and b (via FCP1 homology domain); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 kinase domains (PubMed:18337465, PubMed:19244614). May interact (via SH3 domain) with unc-15 (PubMed:27009202). May interact (via Ig-like C2-type domain 1-3) with cpna-1 (via VWFA domain) (PubMed:23283987). May interact (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) with mel-26 (via MATH domain) (PubMed:22621901). May interact (via DH and PH domains) with rho-1, ced-10, mig-2 and cdc-42 (PubMed:18801371).
messages: Mutants lacking isoform a, isoform b, isoform e and isoform f have an abnormal organization of the myofilament lattice of body wall and pharyngeal muscles (PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:27009202). In body wall muscles, unc-15/paramyosin accumulates in large foci outside thick filaments and myosin heavy chains unc-54 and myo-3 fail to assemble into parallel myofibrils (PubMed:27009202). In addition, myosin thick filaments are disorganized with the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A bands (PubMed:18801371, PubMed:22621901). In mutants lacking isoform b, isoform c, isoform d and isoform f, myo-3 fails to assemble into parallel myofibrils whereas unc-54 and unc-15 localization is normal (PubMed:27009202). Mutants lacking isoform b, isoform c, isoform d and isoform f have defects only in body wall muscle structure (PubMed:16453163). RNAi-mediated knockdown of isoform a or isoform b, isoform c and isoform d causes similar defects in the organization although RNAi-mediated knockdown of isoform c causes a less severe defect in myofilament organization (PubMed:15313609). In mutants lacking isoform a, isoform b, isoform e and isoform f, mei-1 protein levels are decreased by 20 percent (PubMed:22621901). RNAi-mediated knockdown of isoform a, isoform b, isoform e and isoform f but not of isoforms c and d disrupts sca-1 localization to linear punctate structures along in the M line in body wall muscles (PubMed:22768340). RNAi-mediated knockdown has no effect on ovulation (PubMed:17326220).
messages: Protein kinase domains 1 and 2 are predicted to be catalytically inactive (PubMed:16453163). The two kinase domains are required for the organization of thick filament component myosin heavy chain myo-3 but not of myosin heavy chain unc-54 and unc-15/paramyosin (PubMed:27009202).
messages: Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments (PubMed:15313609, PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:23283987, PubMed:27009202). The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role (PubMed:15313609, PubMed:16453163, PubMed:22768340). Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles (PubMed:27009202). By binding mel-26, a substrate adapter of the cul-3 E3 ubiquitin-protein ligase complex, regulates the organization of myosin thick filaments, likely by preventing the degradation of microtubule severing protein mei-1 (PubMed:22621901). Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase rho-1 but not ced-10, mig-2 and cdc-42 (PubMed:18801371). The large isoforms regulate Ca(2+) signaling during muscle contraction by ensuring the correct localization of sarco-endoplamic reticulum Ca(2+) ATPase sca-1 and ryanodine receptor unc-68 (PubMed:22768340). By controlling the contraction and/or organization of pharyngeal muscles, plays a role in the formation of pharyngeal gland cell extension (PubMed:21868609).
messages: The PH domain does not bind inositol 1,4,5-trisphosphate. The PH domain has an unusual closed conformation of the lipid binding site which is lined by negative charged amino acids which probably prevents binding to membrane lipids.
messages: The SH3 domain is required for the organization of thick filament components myosin heavy chain unc-54 and myo-3 and unc-15/paramyosin.

6239:CELE C34G6.5
gene id: 6239:CELE_C34G6.5
uniprot id: O01493
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE Y87G2A.14
gene id: 6239:CELE_Y87G2A.14
uniprot id: Q9NA25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family.
messages: Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine.
messages: Peroxisome membrane

6239:CELE Y17G7B.14
gene id: 6239:CELE_Y17G7B.14
uniprot id: Q9XXI0
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C36C5.12
gene id: 6239:CELE_C36C5.12
uniprot id: O16406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0376 family.
messages: Membrane

6239:CELE C01B12.5
gene id: 6239:CELE_C01B12.5
uniprot id: O17205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C24B9.10
gene id: 6239:CELE_C24B9.10
uniprot id: O76439
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T07C5.3
gene id: 6239:CELE_T07C5.3
uniprot id: Q22296
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F55F8.3
gene id: 6239:CELE_F55F8.3
uniprot id: P91341
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

6239:CELE Y106G6H.5
gene id: 6239:CELE_Y106G6H.5
uniprot id: Q9U300
names: Similarity
messages: Belongs to the GcvT family.

6239:CELE T01G1.3
gene id: 6239:CELE_T01G1.3
uniprot id: G5EFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

6239:CELE C29F4.1
gene id: 6239:CELE_C29F4.1
uniprot id: Q18302
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE D2007.4
gene id: 6239:CELE_D2007.4
uniprot id: P34378
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

6239:CELE F56D1.7
gene id: 6239:CELE_F56D1.7
uniprot id: Q20870
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the RRM DAZ family.
messages: Expressed in the germline from the L2 stage larva.
messages: Germline specific. More strongly expressed during oogenesis than during spermatogenesis. During the larval stages, it is more abundant at the distal region than the proximal region of the gonad. In young adult hermaphrodites, it is expressed at a very low level in the distal mitotic region of the gonad, and begins to accumulate in the meiotic transition zone. Highly expressed in the proximal pachytene region. Not expressed in mature oocytes. Not expressed in the spermatheca. Weakly or not expressed in the germline of adult males.
messages: It is uncertain whether Met-1 or Met-2 is the initiator.
messages: RNA-binding protein that plays a central role in oogenesis, but not for spermatogenesis. Required for meiotic entry and germline differentiation, at the pachytene stage of meiosis I of female germline regardless of the sex of the soma. May act by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR.

6239:CELE D2092.2
gene id: 6239:CELE_D2092.2
uniprot id: P91198
names: Similarity
messages: Belongs to the PPP4R2 family.

6239:CELE C08B11.8
gene id: 6239:CELE_C08B11.8
uniprot id: Q09226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation (By similarity). Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

6239:CELE Y110A2AR.1
gene id: 6239:CELE_Y110A2AR.1
uniprot id: Q9N488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE R10D12.12
gene id: 6239:CELE_R10D12.12
uniprot id: P92012
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

6239:CELE M01E5.5
gene id: 6239:CELE_M01E5.5
uniprot id: O17966
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the type IB topoisomerase family.
messages: Chromosome
messages: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.
messages: Expressed in male germ cells and in mature sperm.
messages: Isoform a: only expressed in embryos (PubMed:9540836). Isoform b: present at all developmental stages (PubMed:9540836). Not expressed during spermatocyte meiosis (PubMed:16943775).
messages: Nucleus
messages: Predominant isoform.
messages: RNAi-mediated knockdown causes abnormal gonad morphology, enlarged sperm nuclei and aberrant progression through meiosis. Oocytes appear to have undergone endomitotic reduplication.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Required for normal spermatogenesis and oogenesis (PubMed:16943775).
messages: nucleolus

6239:CELE Y55F3BL.1
gene id: 6239:CELE_Y55F3BL.1
uniprot id: C0VXV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

6239:CELE B0478.1
gene id: 6239:CELE_B0478.1
uniprot id: Q8WQG9
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by threonine and tyrosine phosphorylation by either of the dual specificity kinases, jkk-1 and mek-1.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Binds to the scaffolding protein, unc-16. Unc-16 also binds other components of the JNK signaling pathway (PubMed:11738026). Interacts with daf-16 (PubMed:15767565).
messages: Cytoplasm
messages: Dually phosphorylated on Thr-276 and Tyr-278, which activates the enzyme.
messages: Expressed in most neurons, including nerve ring, head ganglions, dorsal and ventral nerve cords and tail ganglions (PubMed:10393177). The Thr-276/Tyr-278 phosphorylated form is present in the nerve ring upon heat exposure (PubMed:17894411).
messages: Isoform a and isoform b are expressed in embryo and in all larval stages.
messages: Perikaryon
messages: RNAi-mediated knockdown prevents Mn(2+)-induced dopaminergic CEP neuron degeneration (PubMed:23721876). RNAi-mediated knockdown targeted to neurons results in increased total time in sleep bouts (PubMed:29523076).
messages: Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses (PubMed:17894411). Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate some mechanosensory responses, such as response to touch (PubMed:11566876). Independently of jkk-1 and downstream of mek-1, plays a role in resistance to heavy metals, such as Cu(2+) or Cd(2+) (PubMed:11566876). Regulates germline cell apoptosis in response to heavy metals such as Cu(2+) and arsenite (PubMed:18597494, PubMed:19497412). Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876). Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals (PubMed:29523076). Downstream of jkk-1 but independently of mek-1, positively regulates lifespan (PubMed:15767565).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: axon

6239:CELE C15H11.8
gene id: 6239:CELE_C15H11.8
uniprot id: O17587
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

6239:CELE Y17G7B.2
gene id: 6239:CELE_Y17G7B.2
uniprot id: G5EFZ3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (Probable) (PubMed:31602465). Within the complex, interacts with cfp-1 and wdr-5.1 (PubMed:31602465).
messages: Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation (PubMed:21527717, PubMed:20555324). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Functions as transcriptional regulator (PubMed:28379943). Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:20555324, PubMed:22012258, PubMed:28379943).
messages: Decreased levels of tri- and dimethylated 'Lys-4' of histone H3 in the somatic cells in embryos and young adult animals (PubMed:21527717, PubMed:20555324). Increased dimethylated 'Lys-4' of histone H3 in primordial germ cells (PubMed:21527717). Decreased dimethylated 'Lys-4' of histone H3 in the distal region of the germline (PubMed:21527717). Reduced fertility (PubMed:21527717). RNAi-mediated knockdown results in the extension of lifespan (PubMed:20555324). Decreased levels of trimethylated 'Lys-4' of histone H3 in L3 stage larvae (PubMed:20555324). Leads to a deregulation of fat metabolism and to an accumulation of mono-unsaturated fatty acids in the intestine (PubMed:28379943).
messages: Expressed in somatic and germline tissues (at protein level).
messages: Expressed throughout development and in adult animals.
messages: Nucleus

6239:CELE ZK353.8
gene id: 6239:CELE_ZK353.8
uniprot id: P34631
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Expressed in embryos, L4 larvae and adults. Expressed to a lesser extent between L1 and L3 larval stages.
messages: Expressed in the germline.
messages: Induced upon ER stress (PubMed:19822669, PubMed:17498661). Down-regulated upon heat stress (PubMed:17498661).
messages: Interacts with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus).
messages: Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. May play a role in the ER-associated protein degradation pathway (ERAD) possibly acting as a platform to recruit both ubql-1 and cdc-48.1 and/or cdc-48.2 to the ER during ERAD.
messages: RNAi-mediated knockdown causes a reduction in lifespan. Induces ER stress characterized by the expression of hsp-4, the accumulation of ubiquitinated proteins and an increase in ubql-1 expression.
messages: The intramembrane domain also contains the signal for ER targeting.

6239:CELE F56H11.3
gene id: 6239:CELE_F56H11.3
uniprot id: Q20904
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

6239:CELE C09D4.1
gene id: 6239:CELE_C09D4.1
uniprot id: O01735
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
messages: Membrane

6239:CELE F01D5.3
gene id: 6239:CELE_F01D5.3
uniprot id: Q9XVB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R05F9.8
gene id: 6239:CELE_R05F9.8
uniprot id: P53019
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE T12C9.7
gene id: 6239:CELE_T12C9.7
uniprot id: A9Z1K4
uniprot id: H2L0L4
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE C44E4.5
gene id: 6239:CELE_C44E4.5
uniprot id: A6PVA1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE Y53C12B.1
gene id: 6239:CELE_Y53C12B.1
uniprot id: O18215
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE F39B2.6
gene id: 6239:CELE_F39B2.6
uniprot id: O45499
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

6239:CELE B0212.2
gene id: 6239:CELE_B0212.2
uniprot id: Q5CCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE W07E6.1
gene id: 6239:CELE_W07E6.1
uniprot id: Q9TYV5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Expression increases during the larval stages to adulthood.
messages: Methyltransferase which methylates the carbon-5 position of cytosine 2982 to 5-methylcytosine (m5C2982) in 26S rRNA (PubMed:33289480, PubMed:33283887). May play a role in the translation of leucine and proline codons (Probable). May be required for the translation of specific mRNAs such as mRNAs involved in gonad development, collagen production and cuticle integrity (PubMed:33289480). Plays a role in ensuring the correct localization of the germline-specific protein gld-1 during development (PubMed:33289480). Not required for pre-rRNA processing, the production of mature 5S, 5.8S, 18S or 26S rRNAs or global translation (PubMed:33289480). Plays a role in positively regulating fertility (PubMed:33283887).
messages: RNAi-mediated knockdown in L1 larvae results in sterility (PubMed:33283887). RNAi-mediated knockdown in adults results in reduced egg-laying (PubMed:33289480). RNAi-mediated knockdown from day 0 of adulthood or in the germline does not affect lifespan (PubMed:33289480). RNAi-mediated knockdown in somatic tissues reduces lifespan by 10% and reduces body length and results in morphological defects in the gonad leading to the production of no oocytes (PubMed:33289480). RNAi-mediated knockdown increases resistance to heat stress and increases the speed of locomotion (PubMed:33289480). RNAi-mediated knockdown disrupts the localization of the germline-specific protein gld-1, results in collagen deposition and increases cuticle permeability (PubMed:33289480). RNAi-mediated knockdown reduces the methylation of cytosine to 5-methylcytosine (m5C) in 26S rRNA (PubMed:33289480). RNAi-mediated knockdown does not affect the methylation of cytosine 2381 to 5-methylcytosine (m5C2381) in 26S rRNA (PubMed:33289480).
messages: nucleolus

6239:CELE C14B9.7
gene id: 6239:CELE_C14B9.7
uniprot id: P34334
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

6239:CELE C17G1.7
gene id: 6239:CELE_C17G1.7
uniprot id: Q93244
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide (PubMed:24100226, PubMed:22405203). By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection (PubMed:21840852). Mediates survival in high levels of hydrogen sulfide (PubMed:22405203). By sequestering egl-9, which in turn promotes hif-1-mediated transcription, regulates behavioral responses to hypoxia (PubMed:22405203).
messages: Expressed in AVM sensory neuron, BDU interneurons, pharyngeal I1 interneurons and M2 motor neurons.
messages: Homodimer (PubMed:24100226). Interacts with egl-9 (via C-terminus); the interaction is enhanced by hydrogen disulfide and activates hif-1-mediated transcription (PubMed:22405203).

6239:CELE Y61A9LA.10
gene id: 6239:CELE_Y61A9LA.10
uniprot id: Q9N306
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE M03A1.6
gene id: 6239:CELE_M03A1.6
uniprot id: G5EEM9
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the PA-PLA1 family.
messages: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids, being phosphatidylinositol (PI) its major substrate. PI is a versatile lipid that not only serves as a structural component of cellular membranes, but also plays important roles in signal transduction through distinct phosphorylated derivatives of the inositol head group (PubMed:20668164). Catalyzes the hydrolysis of phosphatidylcholine at sn-2 position in vitro (PubMed:23007400). Regulates asymmetric division, an important property of stem cells in C.elegans, by controlling the subcellular localizations of beta-catenin (PubMed:18497747, PubMed:20668164).
messages: Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL) in vitro.

6239:CELE T28B8.2
gene id: 6239:CELE_T28B8.2
uniprot id: G5ECC6
names: Similarity
messages: Belongs to the insulin family.

6239:CELE C32E8.3
gene id: 6239:CELE_C32E8.3
uniprot id: P91127
names: Function
names: Similarity
messages: Belongs to the TPPP family.
messages: Regulator of microtubule dynamics.

6239:CELE Y44A6E.1
gene id: 6239:CELE_Y44A6E.1
uniprot id: G5ECT0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Expressed in the posterior body muscles. Also detected in the RIFL, RIFR and RIS head neurons.
messages: Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle (PubMed:18191228). Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells (PubMed:25849533). Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline (PubMed:18191228).
messages: Loss of posterior body wall muscle contractions (pBoc).
messages: Membrane
messages: The functional channel is a heterooligomer of pbo-5 and pbo-6. May self-associate to form homooligomers with negligible ion channel activity.

6239:CELE Y25C1A.10
gene id: 6239:CELE_Y25C1A.10
uniprot id: Q9TYL7
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE T23F4.4
gene id: 6239:CELE_T23F4.4
uniprot id: O17264
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE C07G2.1
gene id: 6239:CELE_C07G2.1
uniprot id: Q17802
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed in the germline.
messages: Expressed throughout development but appears to be up-regulated in adults.
messages: Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.
messages: Worms lacking cpg-1 and cpg-2 exhibit defects in cytokinesis during embryo development, more specifically meiotic chromosome segregation, polar-body extrusion, osmotic barrier function and polarization. Embryos lacking cpg-1 and cpg-2 proteins have multiple nuclei lacking plasma membranes and may also have weak egg shells. Oocytes lacking cpg-1 and cpg-2 show cortical granules that are reduced in size.

6239:CELE F19H6.1
gene id: 6239:CELE_F19H6.1
uniprot id: G5EFM9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Cytoplasm
messages: Expressed in hypodermal cells including in hyp7 syncytium but not in seam cells. May be expressed in vulva, uterus and some neurons.
messages: Expressed in the hypodermis at the beginning of embryonic morphogenesis and throughout larval and adult stages.
messages: Probable serine/threonine-protein kinase required for the completion of molting.
messages: RNAi-mediated knockdown results in a failure to shed the cuticle in the middle part of the body at the end of the first molt.

6239:CELE C14B9.6
gene id: 6239:CELE_C14B9.6
uniprot id: P34333
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the N-CoR nuclear receptor corepressors family.
messages: Expressed throughout the developmental stages with a 2-fold increase in late larval (L4) stage.
messages: In larvae, expressed in pharyngeal neurons, ventral and dorsal nerve cords, tail neurons, egg-laying neurons and egg-laying muscles. Detected in the neurons of the pharyngeal nerve ring, head neurons, tail neurons and egg-laying muscles in adults. Detected in male-specific tail ganglia and rays in males.
messages: Interacts with gex-3. Interacts (via C-terminus) with nhr-60.
messages: Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
messages: Mutant animals display a progressive defect in locomotion starting at the L2 stage, showing delayed response to prodding, irregular thrashing movements and a low pharyngeal pumping rate. Worms have shorter body length, convoluted intestine and develop gonadogenesis defects including loss of spermathecae, sterility and larval arrest at L4 stage. They also show abnormal cholinergic signaling leading to early onset of paralysis in the presence of aldicarb, an acetylcholinesterase inhibitor. RNAi-mediated knockdown results in enlargement of mitochondria in the body wall muscle. Muscle-specific knockdown shows an increased level of oxygen consumption.
messages: Nucleus

6239:CELE F41H10.11
gene id: 6239:CELE_F41H10.11
uniprot id: Q9BI89
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

6239:CELE Y47G6A.10
gene id: 6239:CELE_Y47G6A.10
uniprot id: Q9N3T5
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a component of the m-AAA protease complex which is an ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins (By similarity). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (By similarity). Functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (PubMed:22700657, PubMed:25274306, PubMed:25773600). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Binds 1 zinc ion per subunit.
messages: Despite its gene name, this protein is an ortholog of human AFG3L2 and yeast AFG3 and not of human SPG7 and yeast YTA12 (C.elegans ortholog is actually ppgn-1).
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown induces nuclear and mitochondrial transcription of mitochondrial protective genes including chaperone hsp-60 as part of the mitochondrial unfolded protein response (PubMed:25773600, PubMed:25274306, PubMed:22700657). RNAi-mediated knockdown causes nuclear accumulation of transcription factor atfs-1 in intestinal cells (PubMed:22700657). RNAi-mediated knockdown results in mitochondria in intestinal cells which are abnormally elongated (PubMed:25274306). RNAi-mediated knockdown reduces oxygen consumption (PubMed:25773600). RNAi-mediated knockdown also induces the transcription of innate immunity-related genes such as lys-2, abf-2, clec-65 and clec-4 which results in resistance to P.aeruginosa-mediated infection (PubMed:25274306). RNAi-mediated knockdown abolishes transcription up-regulation in an atfs-1 (tm4919) mutant background (PubMed:22700657, PubMed:25274306, PubMed:25773600).

6239:CELE Y37E3.16
gene id: 6239:CELE_Y37E3.16
uniprot id: Q8IA95
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

6239:CELE R01E6.2
gene id: 6239:CELE_R01E6.2
uniprot id: Q21619
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I33 family.
messages: Secreted

6239:CELE F08C6.6
gene id: 6239:CELE_F08C6.6
uniprot id: Q19202
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apyrase family.
messages: By ER stress.
messages: Endomembrane system
messages: Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response.
messages: RNAi-mediated knockdown causes a 50% reduction of progeny numbers and a slower growth. RNAi-mediated knockdown at the L4 larval stage results in a reduced lifespan and in the lysosomal accumulation of lipofuscin in the intestine with age. Motility is decreased and muscle sarcomeres are often patched or wrinkled. Moderate decrease in pharyngeal pumping associated with an abnormal pharynx morphology characterized by irregular and discontinued cell junction protein ajm-1 localization at the beginning and at the end of the procorpus and in the isthmus and a loss of one of the three loops forming the lumen. In addition, causes the up-regulation of ER stress marker hsp-4 which is prevented in an ire-1 mutant background. UDPase and to a lesser extent GDPase activities are reduced.

6239:CELE Y65B4BR.9
gene id: 6239:CELE_Y65B4BR.9
uniprot id: P56407
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for cell specification of the PVN neuron.

6239:CELE K09E9.1
gene id: 6239:CELE_K09E9.1
uniprot id: A0A0K3AYL4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C01C4.1
gene id: 6239:CELE_C01C4.1
uniprot id: Q11088
names: Disruption Phenotype
names: Function
messages: Defective preference between different food odors.
messages: In AWC olfactory sensory neurons, required for the detection of preferred food sources.

6239:CELE R10E11.3
gene id: 6239:CELE_R10E11.3
uniprot id: P34547
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Decreased levels of glr-1 in the ventral nerve cord and corresponding defects in glr-1-dependent behaviors including reduced spontaneous reversal frequency and reduced responsiveness to the nose touch assay which normally induces backward locomotion. Increased levels of ubiquitinated glr-1.
messages: Expressed in a number of tissues including the nervous system, pharynx, body wall muscle, vulva muscle and intestine and is detected in many head and ventral cord neurons.
messages: Interacts with wdr-20 and wdr-48; the catalytic activity of usp-46 is increased in the presence of both wdr-20 and wdr-48. Interacts with glr-1; the interaction results in deubiquitination of glr-1.
messages: Perikaryon
messages: Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity.

6239:CELE K02F6.8
gene id: 6239:CELE_K02F6.8
uniprot id: O16630
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE F09F3.5
gene id: 6239:CELE_F09F3.5
uniprot id: P90820
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxidase family.
messages: Expressed in the hypodermis and gland cells of the pharynx (PubMed:30695063). Specifically, there is low and transient expression from the distal bulb of the pharynx to the anterior of the buccal cavity (PubMed:30695063). Whole body expression levels increase upon entry into the dauer phase (PubMed:30695063).
messages: Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx (PubMed:30695063). It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans (PubMed:24621828, PubMed:30695063).
messages: RNAi-mediated knockdown results in reduced survival in response to infection by E.faecalis.
messages: Secreted

6239:CELE B0334.11
gene id: 6239:CELE_B0334.11
uniprot id: Q8I132
uniprot id: Q9XVW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane

6239:CELE C02B4.2
gene id: 6239:CELE_C02B4.2
uniprot id: Q17589
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE K07D4.3
gene id: 6239:CELE_K07D4.3
uniprot id: O76577
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M67A family. PSMD14 subfamily.
messages: Component of the 19S regulatory cap of the 26S proteasome.
messages: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

6239:CELE R08D7.2
gene id: 6239:CELE_R08D7.2
uniprot id: P30641
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

6239:CELE F32H5.1
gene id: 6239:CELE_F32H5.1
uniprot id: P91991
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C50C3.7
gene id: 6239:CELE_C50C3.7
uniprot id: P34370
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.
messages: Cytoplasm
messages: Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2.
messages: Expressed in tail, cilia, dendrites, axon and male head.
messages: Reduced mating efficiency. Defective sperm. Abnormal distribution of pkd-2.

6239:CELE Y22F5A.1
gene id: 6239:CELE_Y22F5A.1
uniprot id: O62412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y48E1B.3
gene id: 6239:CELE_Y48E1B.3
uniprot id: B7WNB0
uniprot id: O18197
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

6239:CELE F56H6.1
gene id: 6239:CELE_F56H6.1
uniprot id: O45579
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C43G2.2
gene id: 6239:CELE_C43G2.2
uniprot id: V6CJ04
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the BicD family.
messages: Component of a dynein-regulating complex composed of at least bicd-1, dlc-1 and egal-1. Interacts with egal-1 and unc-83.
messages: Expressed during embryonic development.
messages: Expressed in the excretory cell, body wall muscles, vulval muscle cells, PVD and FLP sensory neurons and AVF interneurons.
messages: Nucleus envelope
messages: Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871) (Probable). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795).
messages: Perikaryon
messages: RNAi-mediated knockdown results in increased dendritic branch formation in PVD sensory neurons (PubMed:21205795). RNAi-mediated knockdown in a bicd-1 (ok949) mutant background results in failed nuclei migrations in larval hypodermal P-cells (PubMed:27697906).
messages: dendrite

6239:CELE C27A12.9
gene id: 6239:CELE_C27A12.9
uniprot id: O01966
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F13B12.4
gene id: 6239:CELE_F13B12.4
uniprot id: Q19374
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. Highly divergent.

6239:CELE F33D4.8
gene id: 6239:CELE_F33D4.8
uniprot id: Q688C0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE C05A2.1
gene id: 6239:CELE_C05A2.1
uniprot id: G5EC18
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE T09D3.7
gene id: 6239:CELE_T09D3.7
uniprot id: Q86B33
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE C34F6.7
gene id: 6239:CELE_C34F6.7
uniprot id: O17638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

6239:CELE H27D07.2
gene id: 6239:CELE_H27D07.2
uniprot id: O61908
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R186.8
gene id: 6239:CELE_R186.8
uniprot id: Q7YTL0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

6239:CELE F15C11.1
gene id: 6239:CELE_F15C11.1
uniprot id: G5EFF4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sal C2H2-type zinc-finger protein family.
messages: Expressed throughout the mesodermal (M) lineage from the 1-M stage to the 18-M stage, and in the sex myoblast (SM) sub-lineage from the 2-SM stage to the 16-SM stage, before the cells differentiate (PubMed:28614700). Expression declines significantly in the differentiated coelomocytes (CC) and vulval muscles, but remains in the differentiated body-wall muscles (BWM) (PubMed:28614700). Expressed in the vulval precursor cells (VPC) during larval development (PubMed:10926783).
messages: Nucleus
messages: Transcription factor, involved in positive and negative modulation of transcription (PubMed:12835398, PubMed:28614700). Binds to multiple DNA sequence motifs in the regulatory elements of target genes, including homeobox selector egl-5 and LIM homeobox mec-3 (PubMed:12835398). Involved in cell-fate regulation in multiple lineages, including neuronal, mesodermal and vulval (PubMed:8756352, PubMed:28614700, PubMed:12835398, PubMed:10926783). Required to regulate the fate of PLM touch receptor neurons, acting via negative modulation of transcription of egl-5 and mec-3 (PubMed:12835398). May modulate gene expression by interacting with different transcription factors during neuronal and mesodermal cell development (PubMed:8756352). Promotes the proliferative sex myoblast (SM) fate, in a cell autonomous manner, acting via the SoxC transcription factor sem-2 (PubMed:28614700). Involved in vulval cell-fate determination, acting by regulating expression of homeobox protein lin-39, and may link lin-39 to incoming signaling pathways (PubMed:10926783). Plays a role in detoxification of reactive oxygen species (ROS), by regulating expression of transcription factor skn-1 and the phase II detoxification genes (PubMed:32718932).

6239:CELE F13G3.5
gene id: 6239:CELE_F13G3.5
uniprot id: Q19420
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Cytoplasm
messages: Inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
messages: Isoform 1 is strongly expressed in the AFD and RIA neurons of the head, in the tail and in coelomocytes. Isoform 1 is weakly expressed in nerve cord motor neurons, intestine, and the somatic gonad.
messages: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Required in central interneurons of the mature nervous system for correct localization of synaptic components. Required for thermotaxis.
messages: Worms lacking ttx-7 display defects in thermotaxis behavior and localization of synaptic proteins in RIA neurons yet appear morphologically normal.

6239:CELE ZK1321.1
gene id: 6239:CELE_ZK1321.1
uniprot id: Q09368
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C15B12.6
gene id: 6239:CELE_C15B12.6
uniprot id: Q18008
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in neurons.
messages: Interacts with the receptor complex composed of ilcr-1 and ilcr-2. Also interacts with pik-1.
messages: May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input.

6239:CELE T02B11.7
gene id: 6239:CELE_T02B11.7
uniprot id: O16977
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal, anal depressor, intestinal and vulva muscles, head neurons and head mesodermal cell.
messages: Metalloprotease.
messages: Secreted

6239:CELE K07B1.5
gene id: 6239:CELE_K07B1.5
uniprot id: O01882
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE R08C7.8
gene id: 6239:CELE_R08C7.8
uniprot id: Q21840
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F59A3.8
gene id: 6239:CELE_F59A3.8
uniprot id: P91360
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE E04A4.6
gene id: 6239:CELE_E04A4.6
uniprot id: O44478
names: Similarity
messages: Belongs to the tectonic family.

6239:CELE K04F1.3
gene id: 6239:CELE_K04F1.3
uniprot id: A0A0K3AVP7
uniprot id: Q9TXK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R05D11.1
gene id: 6239:CELE_R05D11.1
uniprot id: Q21733
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Expressed in developing embryos from the pre-comma stage through to hatching (PubMed:20081192). Most highly expressed in larval stage L1 and gradually decreases into adulthood (PubMed:20081192). In larval stages, expressed throughout development in the ventral nerve cord, intestine, gonadal distal tip cells (DTCs) and subsets of head and tail neurons, most strongly in head neurons ASI and ADL (PubMed:20081192).
messages: Expressed in the excretory cell and gonadal distal tip cells (DTCs).
messages: Homodimer (Probable). Interacts with R-SMAD daf-14 and co-SMAD daf-3 (PubMed:20081192). Interacts with orphan nuclear receptor nhr-69 (PubMed:22359515).
messages: Nucleus
messages: Probably a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling (PubMed:10625546, PubMed:20081192). Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-14 (PubMed:10625546, PubMed:20081192). Plays a role in inhibiting mitosis and promoting a switch to meiosis in the germ line, perhaps by down-regulating lag-2 transcription in the gonadal distal tip cells (DTCs) (PubMed:20081192). In cooperation with orphan nuclear receptor nhr-69 modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of the insulin-like peptide daf-28 (PubMed:22359515).

6239:CELE ZK380.1
gene id: 6239:CELE_ZK380.1
uniprot id: O61764
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F37C12.1
gene id: 6239:CELE_F37C12.1
uniprot id: Q20124
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.

6239:CELE T04G9.4
gene id: 6239:CELE_T04G9.4
uniprot id: Q22171
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

6239:CELE M01D7.2
gene id: 6239:CELE_M01D7.2
uniprot id: G5EED5
uniprot id: X5M5X6
uniprot id: X5M914
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE M176.7
gene id: 6239:CELE_M176.7
uniprot id: P34892
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed during hypodermal development.
messages: Hypodermal cells.
messages: May be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development. It has a role in the development of the HYP7 hypodermal syncytium.

6239:CELE Y48G1BL.2
gene id: 6239:CELE_Y48G1BL.2
uniprot id: Q9N3Q4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Increased sensitivity to ionizing radiation with reduced survival compared to wild-type animals. Loss of induction of apoptosis following UV-C or ionizing radiation treatment but no effect on apoptotic response induced by X-ray exposure. Low brood size, reduced viability and sterility, appearance of a high-incidence-of-males (Him) phenotype, and reduced chromosome number due to chromosome fusions.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability.

6239:CELE T28F3.4
gene id: 6239:CELE_T28F3.4
uniprot id: Q8I4F6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R13A1.8
gene id: 6239:CELE_R13A1.8
uniprot id: Q21978
names: Similarity
messages: Belongs to the globin family.

6239:CELE T23G7.1
gene id: 6239:CELE_T23G7.1
uniprot id: Q22703
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the E2F/DP family.
messages: Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059). Interacts (via N-terminus) with efl-1 (PubMed:11463372). Interacts (via C-terminus) with lin-35 (via C-terminus) (PubMed:11463372).
messages: Expressed throughout development. Highly expressed in somatic nuclei, as well as in immature germ cell and oocyte nuclei.
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein (PubMed:11463372, PubMed:17075059). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:11463372, PubMed:17075059). May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A (PubMed:11463372). Can stimulate E2F-dependent transcription (PubMed:17075059). Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repressor in association with the cell cycle regulatory factor efl-1 and the transcriptional repressor lin-35, but may also act as a positive regulator of cell cycle entry (PubMed:12062054). Involved in the regulation of intestinal cell division during postembryonic development, most likely in complex with efl-1 and lin-35 (PubMed:17466069). Promotes germ cell programmed cell death, probably together with efl-1, by positively regulating the expression of the apoptosis proteins ced-3 and ced-4 (PubMed:17881492, PubMed:24752899). In particular, positively regulates the expression of ced-4 in response to starvation (PubMed:24752899). Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins lin-35, lin-37 and lin-52, and is independent of the ced-1, ced-8 and ced-9 pathways (PubMed:17237514).
messages: Uncoordinated movements, also known as an Unc phenotype, most likely due to defective cell cycle progression defects in the Pn.a neuroblast lineage (PubMed:11463372). No obvious vulval development defects (PubMed:11463372). Programmed cell death defect in a ced-3 n2427 mutant background (PubMed:17237514). Double knockout with the n433 mutant of the synthetic multivulva class A protein lin-15A results in a multiple vulva (Muv) phenotype (PubMed:11463372). RNAi-mediated knockdown results in reduced postembryonic intestinal cell divisions (PubMed:12062054).

6239:CELE F43D9.4
gene id: 6239:CELE_F43D9.4
uniprot id: Q20363
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE T05C12.2
gene id: 6239:CELE_T05C12.2
uniprot id: Q22224
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE R04B5.5
gene id: 6239:CELE_R04B5.5
uniprot id: Q21702
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

6239:CELE C29E6.2
gene id: 6239:CELE_C29E6.2
uniprot id: Q18297
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family.
messages: Cell membrane
messages: Expressed in many sensory neurons, including OLQ and IL1 neurons.
messages: Homotetramer.
messages: Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.
messages: Worms exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors.

6239:CELE H37A05.1
gene id: 6239:CELE_H37A05.1
uniprot id: Q9XXT5
names: Similarity
messages: Belongs to the lipin family.

6239:CELE F53G12.7
gene id: 6239:CELE_F53G12.7
uniprot id: O01799
uniprot id: V6CM19
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZK488.4
gene id: 6239:CELE_ZK488.4
uniprot id: O17020
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K02G10.5
gene id: 6239:CELE_K02G10.5
uniprot id: X5LV99
uniprot id: X5M903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

6239:CELE C36A4.2
gene id: 6239:CELE_C36A4.2
uniprot id: Q27476
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F54D7.4
gene id: 6239:CELE_F54D7.4
uniprot id: O44730
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in body wall muscles.
messages: No visible phenotype (PubMed:19737747, PubMed:22829780). No defect in the positioning of ASI and ASH neuron cell bodies (PubMed:22829780). No defect in the positioning of PQV, PVP, RMEV, HSN adn AVK axons in the ventral nerve cord (PubMed:19737747).
messages: Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
messages: Secreted

6239:CELE R13A1.2
gene id: 6239:CELE_R13A1.2
uniprot id: N1NV09
uniprot id: S6F510
uniprot id: S6FCX2
uniprot id: S6FWN4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05E11.3
gene id: 6239:CELE_T05E11.3
uniprot id: Q22235
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adults show increased sensitivity to cisplatin, sodium arsenite and zinc. RNAi-mediated knockdown results in induction of the unfolded protein response.
messages: Belongs to the heat shock protein 90 family.
messages: Endoplasmic reticulum lumen
messages: Molecular chaperone that functions in the processing and transport of secreted proteins.

6239:CELE W07G1.5
gene id: 6239:CELE_W07G1.5
uniprot id: Q69Z08
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme
messages: cilium membrane
messages: cytoskeleton

6239:CELE ZK1236.3
gene id: 6239:CELE_ZK1236.3
uniprot id: P34619
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner.
messages: Binds through its N-terminal region to the N-terminal region of sop-2.
messages: Expressed at all developmental stages with levels declining as development proceeds.
messages: Nucleus
messages: Worms exhibit early larval lethality and anterior to posterior cell fate transformation in a Hox gene-dependent manner. Hermaphrodites show vulva defects, partial hermaphrodite-to-male sexual transformation and are sterile.

6239:CELE Y66D12A.14
gene id: 6239:CELE_Y66D12A.14
uniprot id: Q95Q02
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE C32D5.12
gene id: 6239:CELE_C32D5.12
uniprot id: Q09491
names: Similarity
messages: Belongs to the 3-beta-HSD family.

6239:CELE F15D4.8
gene id: 6239:CELE_F15D4.8
uniprot id: Q7YX32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: Secreted

6239:CELE F10F2.2
gene id: 6239:CELE_F10F2.2
uniprot id: Q19311
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity).

6239:CELE C28G1.3
gene id: 6239:CELE_C28G1.3
uniprot id: Q18286
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE ZC410.10
gene id: 6239:CELE_ZC410.10
uniprot id: G5EFZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

6239:CELE M106.4
gene id: 6239:CELE_M106.4
uniprot id: Q09580
names: Subunit
messages: Homodimer.

6239:CELE K02F2.6
gene id: 6239:CELE_K02F2.6
uniprot id: O44986
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE K12H4.1
gene id: 6239:CELE_K12H4.1
uniprot id: P34522
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Prospero homeodomain family.
messages: Expressed in the excretory cell at the 1.5-fold embryonic stage and throughout larval development.
messages: Lethality at larval stage, L1. Surviving animals do not develop into fertile adults. Animals have abnormal sensory function with their bodies harboring lesions and signs of progressive degradation. Defective excretory canal formation with down-regulation of genes, including exc-5, ifb-1, gck-3 and aqp-8, involved in this process. Seventy percent of L1 larvae do not form excretory canals, but have a large vacuole around the excretory cell body. The remaining larvae form impaired excretory canals that rarely extend beyond the pharyngeal-intestinal valve and do not extend to the somatic gonad. Furthermore, some animals develop a cyst in the lumen of the excretory canal. RNAi-mediated knockdown in larvae largely results in arrest at the L1 larval stage. Surviving worms have altered excretory canal growth with a large vacuole and cyst in the excretory cell body and lumen, respectively, and the formation of a thin canal extension.
messages: Nucleus
messages: The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
messages: Transcription factor involved in developmental processes (By similarity). Controls the transcription of genes required for excretory canal formation (PubMed:23334499).

6239:CELE F21A3.6
gene id: 6239:CELE_F21A3.6
uniprot id: O17824
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Monomer.

6239:CELE F22D6.5
gene id: 6239:CELE_F22D6.5
uniprot id: Q19727
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

6239:CELE B0361.2
gene id: 6239:CELE_B0361.2
uniprot id: Q10946
names: Similarity
messages: Belongs to the CWF19 family.

6239:CELE ZC204.15
gene id: 6239:CELE_ZC204.15
uniprot id: P91549
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C06G3.10
gene id: 6239:CELE_C06G3.10
uniprot id: Q21444
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG2 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi morphology and function.

6239:CELE C36B1.14
gene id: 6239:CELE_C36B1.14
uniprot id: Q3S1J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

6239:CELE F43H9.1
gene id: 6239:CELE_F43H9.1
uniprot id: A0A131MCK1
uniprot id: Q20376
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

6239:CELE F28H1.4
gene id: 6239:CELE_F28H1.4
uniprot id: P83386
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T15D6.10
gene id: 6239:CELE_T15D6.10
uniprot id: O02317
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE R11E3.5
gene id: 6239:CELE_R11E3.5
uniprot id: H2L0B0
uniprot id: Q86PJ5
uniprot id: Q8MXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F59B2.2
gene id: 6239:CELE_F59B2.2
uniprot id: P34479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic granule
messages: Expressed in the head, tail, body and ventral nerve cord neurons, muscles of the vulva, and intestine.
messages: Membrane
messages: Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin.

6239:CELE F45G2.10
gene id: 6239:CELE_F45G2.10
uniprot id: O62252
names: Function
names: Similarity
messages: Belongs to the MIP18 family.
messages: May play a role in chromosome segregation through establishment of sister chromatid cohesion.

6239:CELE C44C3.3
gene id: 6239:CELE_C44C3.3
uniprot id: Q8IFY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T22F3.11
gene id: 6239:CELE_T22F3.11
uniprot id: Q94307
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T10B11.5
gene id: 6239:CELE_T10B11.5
uniprot id: Q9TZH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

6239:CELE C07E3.1
gene id: 6239:CELE_C07E3.1
uniprot id: Q17784
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TFP11/STIP family.
messages: Detected in muscle cells from body, pharynx and vulva, in neurons from head and tail, in pharyngeal gland and in tail hypodermal cells.
messages: Detected in oocyte, embryo, larval stage 1 to 4, and in adult.
messages: Identified in the spliceosome C complex (By similarity). Can assemble into large rod-like polymers.
messages: May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival.
messages: Nucleus

6239:CELE F08B12.2
gene id: 6239:CELE_F08B12.2
uniprot id: Q19189
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5/prx-5 receptor from peroxisomes to the cytosol, thereby promoting PEX5/prx-5 recycling (By similarity). The retrotranslocation channel is composed of PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5/prx-5 through the peroxisomal membrane (By similarity). PEX12/prx-12 also regulates PEX5/prx-5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10/prx-10 (By similarity). When PEX5 recycling is compromised, PEX12/prx-12 stimulates PEX10-mediated polyubiquitination of PEX5/prx-5, leading to its subsequent degradation (By similarity).
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel.
messages: Peroxisome membrane
messages: The RING-type zinc-finger is degenerated and only coordinates one zinc ions, preventing E3 ubiquitin-protein ligase activity.
messages: The three subunits of the retrotranslocation channel (PEX2/prx-2, PEX10/prx-10 and PEX12/prx-12) coassemble in the membrane into a channel with an open 10 Angstrom pore. The RING-type zinc-fingers that catalyze PEX5/prx-5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex.

6239:CELE T12E12.6
gene id: 6239:CELE_T12E12.6
uniprot id: A5A631
names: Similarity
messages: Belongs to the peptidase M1 family.

6239:CELE F53A2.6
gene id: 6239:CELE_F53A2.6
uniprot id: D1MN85
uniprot id: O45551
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Cytoplasm
messages: Defects can cause a delay in spermatogenesis, temperature-sensitive sterility and defective sperm.
messages: EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to interact with other partners, including pgl-1 (PubMed:11641215). Interacts with ifet-1 (PubMed:19786575).
messages: Enriched in the germline from L3 larvae to adults; regions of the gonad undergoing spermatogenesis. Expressed in germ granules (P granules); when associated with pgl-1.
messages: Expressed both maternally and zygotically. Ubiquitous embryonic expression until the 100-200 cell stage then disappears by the 300-400 cell stage. Expressed again in L3 larvae through to adulthood.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. Required for progression through meiotic divisions during spermatogenesis and for the production of viable sperm. It is not required during oogenesis.

6239:CELE ZK970.4
gene id: 6239:CELE_ZK970.4
uniprot id: Q23680
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: RNAi-mediated knockdown results in increased protein aggregation in the oocytes of sperm-deficient young adult females which is not eliminated by mating.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (PubMed:29168500). This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (PubMed:29168500). The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates (PubMed:29168500). Lysosomal acidification also leads to changes in mitochondrial morphology and function (PubMed:29168500). Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity (PubMed:29168500). In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (PubMed:29168500).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE Y57G11C.11
gene id: 6239:CELE_Y57G11C.11
uniprot id: O18235
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

6239:CELE Y54G11A.8
gene id: 6239:CELE_Y54G11A.8
uniprot id: Q7K742
uniprot id: Q9XW00
names: Similarity
messages: Belongs to the TTC19 family.

6239:CELE C37H5.3
gene id: 6239:CELE_C37H5.3
uniprot id: H2KZ86
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts coordinately with phospholipase atgl-1 within the lipolytic cascade to distribute stored energy to tissues to maintain energy levels during the dauer phase. Localizes atgl-1 to lipid droplets, possibly to facilitate triglyceride hydrolysis. Regulates lipid droplet size, lipid content, the exchange of lipids between lipid droplets and fusion of lipid droplets during the dauer phase.
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
messages: Expressed in the hypodermis and intestine.
messages: Increased survival of dauer larvae and reduced lipase activity in a daf-2 constitutive dauer phase mutant background.
messages: Interacts with atgl-1; the interaction tethers atgl-1 to lipid droplets.
messages: Lipid droplet

6239:CELE T10B11.2
gene id: 6239:CELE_T10B11.2
uniprot id: Q9TZI1
names: Function
messages: Catalyzes the phosphorylation of ceramide to form ceramide 1-phosphate.

6239:CELE T05E7.1
gene id: 6239:CELE_T05E7.1
uniprot id: O01862
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE W02A2.7
gene id: 6239:CELE_W02A2.7
uniprot id: Q9XUB2
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Asymmetrically localized to the anterior of the zygote before mitotic division, then differentially distributed to the somatic blastomere precursor cells.
messages: Cytoplasm
messages: Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos (PubMed:10882103, PubMed:18199581, PubMed:18842813, PubMed:30279189). Also affects formation of intestinal cells (PubMed:10882103). Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA (PubMed:27594427).
messages: Interacts (when phosphorylated on Thr-186) with plk-1 (via POLO box domain) and plk-2 (via POLO box domain).
messages: Phosphorylation on Ser-458 by par-1 promotes localization of the protein to the anterior cytoplasm of the zygote (PubMed:18842813). Phosphorylation by mbk-1 appears to be required for subsequent phosphorylation by plk-1 (PubMed:18199581).
messages: RNAi-mediated knockdown reduces the expression of pie-1 in P2 blastomeres (PubMed:30279189). RNAi-mediated knockdown in mex-6 pk440 mutant background causes a loss in plk-1 asymmetric distribution during the first embryonic cell divisions.

6239:CELE F11A10.5
gene id: 6239:CELE_F11A10.5
uniprot id: Q19337
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

6239:CELE F16A11.2
gene id: 6239:CELE_F16A11.2
uniprot id: P90838
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs (PubMed:25366321). Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress-induced unfolded protein response (PubMed:25366321, PubMed:25429148). Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1 (PubMed:25429148).
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.
messages: Mutants are sterile and few are viable (PubMed:25366321, PubMed:25429148). Mutants have a slower growth rate, reduced lifespan and have defective vulval development displaying a severe protruding vulva phenotype (PubMed:25366321, PubMed:25429148). Mutants have disrupted RNA ligase activity which results in the presence of unligated tRNAs and defective tRNA processing (PubMed:25366321). RNAi-mediated knockdown results in reduced sensitivity to tunicamycin-induced endoplasmic reticulum (ER) stress and significantly reduced levels of spliced xbp-1 mRNA under tunicamycin-induced ER stress and non-stressed conditions (PubMed:25429148). RNAi-mediated knockdown in dopamine neurons enhances degenerative effects induced by alpha-synuclein and the neurotoxin, 6-OHDA (PubMed:25429148).
messages: Nucleus

6239:CELE ZK783.1
gene id: 6239:CELE_ZK783.1
uniprot id: I6Z0I7
uniprot id: I7J4C8
uniprot id: I7J4C9
uniprot id: I7K4J2
uniprot id: I7K4J6
uniprot id: I7LFE6
uniprot id: I7LHV8
uniprot id: I7LHV9
uniprot id: Q23587
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C54F6.9
gene id: 6239:CELE_C54F6.9
uniprot id: O16442
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y17G9B.5
gene id: 6239:CELE_Y17G9B.5
uniprot id: Q9N580
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

6239:CELE B0365.7
gene id: 6239:CELE_B0365.7
uniprot id: G5EDV4
names: Similarity
messages: Belongs to the dynein heavy chain family.

6239:CELE C51F7.2
gene id: 6239:CELE_C51F7.2
uniprot id: G5EF81
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F35G12.4
gene id: 6239:CELE_F35G12.4
uniprot id: Q20059
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat WDR48 family.
messages: Changed locomotion behavior with mutants displaying decreased reversal frequencies consistent with decreased glutamergic signaling.
messages: Expressed in several head neurons and cells in the tail including the anal depressor cell.
messages: Interacts with usp-46; the interaction increases the catalytic activity of usp-46 in the presence of wdr-20.
messages: Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.

6239:CELE C25H3.3
gene id: 6239:CELE_C25H3.3
uniprot id: Q18187
names: Similarity
messages: Belongs to the thioesterase PaaI family.

6239:CELE ZC239.6
gene id: 6239:CELE_ZC239.6
uniprot id: P91556
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE B0554.7
gene id: 6239:CELE_B0554.7
uniprot id: A0A0K3ART0
uniprot id: A0A0K3AVB0
uniprot id: A0A0K3AXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE T01G6.2
gene id: 6239:CELE_T01G6.2
uniprot id: O16968
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F46F3.1
gene id: 6239:CELE_F46F3.1
uniprot id: H2L2F8
uniprot id: Q9XVN4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZC449.3
gene id: 6239:CELE_ZC449.3
uniprot id: Q8MPS3
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE B0212.1
gene id: 6239:CELE_B0212.1
uniprot id: O45067
uniprot id: U4PEQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE F52D10.5
gene id: 6239:CELE_F52D10.5
uniprot id: Q20657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Membrane

6239:CELE F52H2.6
gene id: 6239:CELE_F52H2.6
uniprot id: O17397
names: Similarity
messages: Belongs to the DIMINUTO family.

6239:CELE ZC116.3
gene id: 6239:CELE_ZC116.3
uniprot id: Q20911
names: Function
names: Subcellular Location Annotation
messages: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake.
messages: Secreted

6239:CELE T20G5.1
gene id: 6239:CELE_T20G5.1
uniprot id: P34574
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448).
messages: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (By similarity). May interact with beta arrestin arr-1 (PubMed:15878875).
messages: Cytoplasmic vesicle membrane
messages: RNAi-mediated knockdown results in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space.
messages: The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
messages: The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).
messages: coated pit

6239:CELE C03D6.5
gene id: 6239:CELE_C03D6.5
uniprot id: Q17603
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

6239:CELE C56G2.1
gene id: 6239:CELE_C56G2.1
uniprot id: Q09285
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47G6A.9
gene id: 6239:CELE_Y47G6A.9
uniprot id: Q9N3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

6239:CELE F44F4.13
gene id: 6239:CELE_F44F4.13
uniprot id: Q20411
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A G protein-coupled receptor required for olfactory imprinting a requisite in ordorant response such as benzaldehyde and isoamylalcohol.
messages: Belongs to the nematode receptor-like protein sra family.
messages: Expressed in interneurons AIY and AVB in L1 larvae. In adults, strong expression is seen in AIY and AIA but only weak expression in AVB.
messages: Membrane
messages: Worms exhibit olfactory imprinting to benzaldehyde and isoamylalcohol.

6239:CELE K06A1.4
gene id: 6239:CELE_K06A1.4
uniprot id: Q09587
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y53C12B.2
gene id: 6239:CELE_Y53C12B.2
uniprot id: O18216
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNO1 family.
messages: nucleolus

6239:CELE Y41D4B.21
gene id: 6239:CELE_Y41D4B.21
uniprot id: Q95Y05
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T10H4.6
gene id: 6239:CELE_T10H4.6
uniprot id: O45774
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE D2023.6
gene id: 6239:CELE_D2023.6
uniprot id: O17735
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

6239:CELE H23L24.2
gene id: 6239:CELE_H23L24.2
uniprot id: Q9N5L3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F09G8.8
gene id: 6239:CELE_F09G8.8
uniprot id: P34393
names: Subcellular Location Annotation
messages: Secreted

6239:CELE R10H1.5
gene id: 6239:CELE_R10H1.5
uniprot id: Q7Z0M7
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in the hypodermis, rectum and to a lesser extent in pharyngeal muscles and intestine.
messages: Metalloprotease.
messages: Secreted

6239:CELE T02G5.12
gene id: 6239:CELE_T02G5.12
uniprot id: Q22109
names: Subcellular Location Annotation
messages: Membrane

6239:CELE D2005.2
gene id: 6239:CELE_D2005.2
uniprot id: Q93409
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Expressed in the ALA neuron in L4 stage larvae.
messages: May be processed by convertase egl-3.
messages: Neuropeptide-like protein (PubMed:30229400). Plays a role in behaviors associated with a sleep-like state induced by stress (SIS), acting in concert with the FARP (FMRFamide related) peptides, flp-13 and flp-24 (PubMed:27546573).
messages: Secreted

6239:CELE H38K22.2
gene id: 6239:CELE_H38K22.2
uniprot id: Q9U3C8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with the cullin cul-3. Interacts with ubiquitin via its UBA-like domain. Interacts with ned-8/nedd8.
messages: Nucleus
messages: Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.

6239:CELE C02D5.2
gene id: 6239:CELE_C02D5.2
uniprot id: P34276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Membrane

6239:CELE T19B10.7
gene id: 6239:CELE_T19B10.7
uniprot id: Q22560
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adult germline tissues.
messages: Belongs to the importin alpha family.
messages: Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).
messages: Cytoplasm
messages: Does not contain ARM repeats, but instead Ser charged repeats. May have specificity for cargos distinct from that of other importin alpha subunits.
messages: Expressed very weakly in early larvae, levels of expression increase in L4 and adult stages when germ cells are continually proliferating.
messages: Forms a complex with an importin beta subunit.

6239:CELE K02A2.2
gene id: 6239:CELE_K02A2.2
uniprot id: Q09572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE K10D3.3
gene id: 6239:CELE_K10D3.3
uniprot id: Q21417
names: Similarity
messages: Belongs to the TAF11 family.

6239:CELE F32D8.12
gene id: 6239:CELE_F32D8.12
uniprot id: Q7JLJ0
uniprot id: Q8I4K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Peroxisome

6239:CELE C39E9.9
gene id: 6239:CELE_C39E9.9
uniprot id: Q18536
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C35B1.1
gene id: 6239:CELE_C35B1.1
uniprot id: P52478
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.
messages: Interacts with ubr-1 and rfp-1 (PubMed:14732404). Interacts with ubc-13 (PubMed:15530417).
messages: Worms are viable, fertile, and do not show any obvious anomaly.

6239:CELE K01H12.3
gene id: 6239:CELE_K01H12.3
uniprot id: A0A061AKS3
uniprot id: Q21104
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T19C3.8
gene id: 6239:CELE_T19C3.8
uniprot id: P49594
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Component of a complex containing fem-1, fem-2 and fem-3 (PubMed:23760267). Interacts (via N-terminus) with fem-1 and fem-3 (PubMed:17609115, PubMed:23760267, PubMed:8824590). Component of the CBC(fem-1) E3 ubiquitin-protein ligase complex, at least composed of cul-2, elc-1, tra-1, fem-1, fem-2 and fem-3; mediates the ubiquitination and subsequent proteasomal degradation of tra-1 (PubMed:17609115). Interacts with tra-1 (PubMed:17609115). Interacts with sel-10 (PubMed:15306688).
messages: Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin-dependent protein kinase unc-43/CAMKII in vitro (PubMed:11559703, PubMed:23760267). Involved in the regulation of sex determination (PubMed:8824590). Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes (PubMed:17609115). Promotes apoptosis (PubMed:11559703).

6239:CELE C34D4.1
gene id: 6239:CELE_C34D4.1
uniprot id: Q18452
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme

6239:CELE C29E4.12
gene id: 6239:CELE_C29E4.12
uniprot id: Q8MNU8
names: Similarity
messages: Belongs to the FMC1 family.

6239:CELE T25F10.2
gene id: 6239:CELE_T25F10.2
uniprot id: G5EEL5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TGF-beta family.
messages: Expressed in L4 larval stage primarily in neurons, including ventral cord neurons DA, DB, VA and VB; the lateral excretory canal associated CAN cells; and anterior neurons AVK, DVA, I5, M1, M2, M4 and M5.
messages: Expressed in embryos just prior to hatching and remains constant in most cells throughout the larval and adult stages (PubMed:9847238). Expressed by AVA command interneurons (PubMed:23019581).
messages: Homodimer; disulfide-linked (By similarity). Interacts with drag-1 (PubMed:24004951).
messages: Ligand for the serine/threonine-protein kinase receptor type-1 sma-6 which activates a TGF-beta-like signaling pathway (PubMed:24004951). Multifunctional protein that is involved in body size, male ectodermal patterning, innate immunity, lipid metabolism and neural plasticity (PubMed:10021351, PubMed:9847238, PubMed:12176330, PubMed:29162682, PubMed:23019581). Dose-dependent regulator of body size, probably influencing the sizes of some or all cells rather than their number (PubMed:10021351, PubMed:9847238, PubMed:22189608). Plays a role in patterning of male-specific genital sensilla (simple sense organs), known as rays, and mating-associated structures, spicules (PubMed:10021351, PubMed:9847238). Plays a protective role in response to infection by the Gram-negative bacterium S.marcescens, by activating expression of genes involved in innate immunity (PubMed:12176330). Regulator of lipid homeostasis, acting non cell-autonomously in the hypodermis; partly dependent on the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:29162682). Required for aversive olfactory learning of pathogenic bacteria in adults (PubMed:23019581). Involved in gland cell morphology, possibly via activation of a Smad-independent TGF-beta signaling pathway (PubMed:24690231). Required to oppose the autoregulation of expression of Runt-related transcription factor rnt-1.
messages: Reduced body size (PubMed:10021351). Abnormalities in the male tail (PubMed:10021351). Disrupted aversive learning (PubMed:23019581).
messages: Secreted

6239:CELE Y69H2.3
gene id: 6239:CELE_Y69H2.3
uniprot id: A8WI97
uniprot id: L8E6L7
uniprot id: L8E811
uniprot id: L8EC36
uniprot id: Q8I4B8
uniprot id: Q8I4B9
uniprot id: Q9U1T5
uniprot id: Q9U1T6
names: Subcellular Location Annotation
messages: Secreted

6239:CELE K06A4.3
gene id: 6239:CELE_K06A4.3
uniprot id: Q21253
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the villin/gelsolin family.
messages: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping) (PubMed:18640981, PubMed:20392036). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends (PubMed:18640981, PubMed:20392036). By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development (PubMed:26074078).
messages: Cleavage by caspase ced-3 activates its actin-severing function and is required for the elimination of presynaptic components during development.
messages: Monomer. Binds to actin monomers and filaments.
messages: cytoskeleton

6239:CELE K08B4.3
gene id: 6239:CELE_K08B4.3
uniprot id: Q9TYY5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C48B6.2
gene id: 6239:CELE_C48B6.2
uniprot id: O01513
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Mitochondrion

6239:CELE ZK418.5
gene id: 6239:CELE_ZK418.5
uniprot id: Q23483
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE Y40H7A.10
gene id: 6239:CELE_Y40H7A.10
uniprot id: Q9XWA4
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y92H12A.5
gene id: 6239:CELE_Y92H12A.5
uniprot id: Q2AAB7
uniprot id: W6RTG0
names: Similarity
messages: Belongs to the THADA family.

6239:CELE C34B2.6
gene id: 6239:CELE_C34B2.6
uniprot id: O44952
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mitochondrion (PubMed:22700657).
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown causes transcription factor atfs-1 accumulation in mitochondria.

6239:CELE D1014.7
gene id: 6239:CELE_D1014.7
uniprot id: M1ZJ39
uniprot id: M1ZMI7
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y37E11AR.5
gene id: 6239:CELE_Y37E11AR.5
uniprot id: Q965X5
uniprot id: U4PLL6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K04G11.2
gene id: 6239:CELE_K04G11.2
uniprot id: G5EGS7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in seam cells with temporal changes in expression level; undetectable in L1 and L2 larval stages, then expressed at the L3 stage, declining at the late L4 stage and expressed only weakly in young adults (PubMed:19500563). Expressed in the vulval precursor cells (VPCs) (PubMed:15020414).
messages: Multimer (PubMed:15020414). May interact with mediator complex subunit mdt-29 (PubMed:15020414).
messages: Nucleus
messages: Putative transcription factor (PubMed:19500563). Positive regulator of the lin-12/Notch signaling pathway (PubMed:15020414). Binds to specific DNA sequences in regulatory elements (PubMed:19500563). Involved in cell fate decisions that require cell-cell interactions, such as the anchor cell (AC) / ventral uterine (VU) precursor cell fate decision (PubMed:15020414). Heterochronic protein which controls the choice of stage specific cell fates, including the larval L3 stage-specific fate of seam cells (PubMed:19500563). Involved in regulating the temporal expression pattern of hunchback-like protein hbl-1, thereby playing a role in the progression between larval stages L2 and L3 (PubMed:19500563).
messages: RNAi-mediated knockdown suppresses the hermaphrodite gonadal development and egg-laying defects in a lin-12 mutant background.
messages: Widely expressed, including in pharyngeal muscle cells and body wall muscle cells.

6239:CELE F33H1.5
gene id: 6239:CELE_F33H1.5
uniprot id: Q19992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE ZK836.1
gene id: 6239:CELE_ZK836.1
uniprot id: Q23628
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Dose-dependent regulator of body length and shape.

6239:CELE M02H5.4
gene id: 6239:CELE_M02H5.4
uniprot id: Q966H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T05E11.1
gene id: 6239:CELE_T05E11.1
uniprot id: P49041
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

6239:CELE C05E4.3
gene id: 6239:CELE_C05E4.3
uniprot id: G5EE40
names: Similarity
messages: Belongs to the serpin family.

6239:CELE T22B11.5
gene id: 6239:CELE_T22B11.5
uniprot id: O61199
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: Mitochondrion matrix
messages: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

6239:CELE T21H8.4
gene id: 6239:CELE_T21H8.4
uniprot id: O62420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE Y54E10A.5
gene id: 6239:CELE_Y54E10A.5
uniprot id: Q9N3F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Member of the pointed-end complex of the dynactin shoulder complex.
messages: cytoskeleton

6239:CELE M04C9.1
gene id: 6239:CELE_M04C9.1
uniprot id: A5JYY7
uniprot id: A5JYY8
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE T23F11.1
gene id: 6239:CELE_T23F11.1
uniprot id: P49596
names: Cofactor
names: Similarity
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.

6239:CELE W02B9.1
gene id: 6239:CELE_W02B9.1
uniprot id: Q967F4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cadherins are calcium-dependent cell adhesion proteins (PubMed:25938815, PubMed:25850673). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:25938815, PubMed:25850673). Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton (PubMed:26412237).
messages: Cell junction
messages: Cell membrane
messages: Embryonic lethal (PubMed:20689042, PubMed:25850673). Hammerhead phenotype characterized by morphogenetic defects before the start of body elongation, due to improper closure of hypodermis (PubMed:9531567, PubMed:25850673). Humpback phenotype with embryos containing dorsal humps (PubMed:20689042). Embryos also exhibit defective actin structures including loss of actin at cell-cell junctions and detached thick actin bundles called circumferential filament bundles that insert at right angles to junctional actin (PubMed:20689042). RNAi-mediated knockdown results in ingression defects in primordial germ cells (PubMed:22675206).
messages: Isoform a is present in all embryonic blastomeres at early stages of development (PubMed:9531567, PubMed:25938815). Expressed throughout gastrulation and in primordial germ cells (PubMed:22675206).
messages: Isoform a is required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567, PubMed:12847081). Required for proper localization of other junctional components, such as hmp-1, hmp-2, jac-1 and pac-1 (PubMed:9531567, PubMed:25938815). Recruitment of pac-1 is required to establish cell polarity, independent of its role in cell adhesion (PubMed:25938815). Required for primodial germ cell ingression and adherence to endodermal cells during gastrulation (PubMed:20515680, PubMed:22675206).
messages: Isoform b is involved in axonal guidance in a subset of motor neurons.
messages: Isoform b is neuron-specific (PubMed:11790304). Isoform a is located in epidermal cells (at protein level) (PubMed:9531567).
messages: Monomer in solution (PubMed:20689042). Isoform a is a component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:20689042, PubMed:25850673). Isoform a interacts with hmp-2; the interaction is direct (PubMed:10952315, PubMed:20689042, PubMed:25850673, PubMed:26412237). Isoform a interacts (via intracellular domain) with jac-1 (PubMed:12847081, PubMed:25938815).
messages: Phosphorylation at T-2912 increases the binding affinity for hmp-2.
messages: Sumoylated. Sumoylation prevents accumulation at adherens junctions and decreases the binding affinity for hmp-2.
messages: The cytoplasmic domain is necessary for binding to jac-1.
messages: adherens junction

6239:CELE ZC239.14
gene id: 6239:CELE_ZC239.14
uniprot id: P91561
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE Y53C12A.4
gene id: 6239:CELE_Y53C12A.4
uniprot id: O18211
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mo25 family.
messages: RNAi-mediated knockdown results in the production of additional AVM/PVM neuronal precursors.
messages: Regulates asymmetric cell division in Q.p neuroblast lineage (PubMed:23267054). Plays a role in cell shedding during embryogenesis (PubMed:22801495).
messages: spindle pole

6239:CELE C07A9.11
gene id: 6239:CELE_C07A9.11
uniprot id: P34322
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

6239:CELE F23H11.9
gene id: 6239:CELE_F23H11.9
uniprot id: O01916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
messages: Mitochondrion inner membrane

6239:CELE Y71H2AM.24
gene id: 6239:CELE_Y71H2AM.24
uniprot id: Q3V5J2
names: Similarity
messages: Belongs to the TBCC family.

6239:CELE H38K22.5
gene id: 6239:CELE_H38K22.5
uniprot id: O61394
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE F36G9.1
gene id: 6239:CELE_F36G9.1
uniprot id: O45472
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F13B10.2
gene id: 6239:CELE_F13B10.2
uniprot id: G5ECE5
uniprot id: G5EEC0
uniprot id: P50880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Cytoplasm
messages: The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

6239:CELE T04C10.2
gene id: 6239:CELE_T04C10.2
uniprot id: Q9BI71
uniprot id: Q9BI72
names: Similarity
messages: Belongs to the epsin family.

6239:CELE K08B12.3
gene id: 6239:CELE_K08B12.3
uniprot id: O01581
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

6239:CELE C05G5.4
gene id: 6239:CELE_C05G5.4
uniprot id: P53596
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

6239:CELE C42C1.2
gene id: 6239:CELE_C42C1.2
uniprot id: A3QMB1
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE Y47H9C.4
gene id: 6239:CELE_Y47H9C.4
uniprot id: Q9XWD6
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accumulation of cell corpses (PubMed:26598553). Appears immunocompromised resulting in susceptibility to bacterial infection (PubMed:6857247, PubMed:1936965, PubMed:18606143). Reduced or lack of association of ppk-3 and rab-7 with the phagosomal surface (PubMed:18351800). Defective in the recruitment of lysosomes to phagosomes (PubMed:16740477). Double knockout with the P-granule component pgl-1 results in an increased number of cell corpses in the gonad as compared to the ced-1 single mutant (PubMed:26598553). Conversely, double knockout with pgl-1 or pgl-3 results in reduced somatic cell apoptosis (PubMed:27650246). Double knockout with the synthetic multivulva class B protein hpl-2 results in reduced somatic cell apoptosis at 25 degrees Celsius (PubMed:27650246). Triple knockout with hpl-2 and pgl-1 partially recovers the reduced somatic cell apoptotic cell defect in the ced-1 and hpl-2 double knockout (PubMed:27650246). Triple knockout with hpl-2 and pgl-1 and knockdown with either ced-3 or ced-4 reduces the somatic cell apoptosis defect in the ced-1, hpl-2 and pgl-1 triple knockout (PubMed:27650246). Double knockout with hpl-2 and knockdown with either pgl-1, pgl-3, glh-1 or glh-4 RNAi rescues the reduced somatic cell apoptotic cell defect in the ced-1 and hpl-2 double knockout (PubMed:27650246). Knockout with RNAi-mediated knockdown of synthetic multivulva class B proteins lin-9, lin-35, lin-37 or lin-54 results in reduced somatic cell apoptosis (PubMed:27650246).
messages: Cell membrane
messages: Expressed in engulfing cells and syncytium hypodermal cells. Ced-7 is necessary for clustering around cell corpses prior to engulfment.
messages: Interacts (via C-terminus) with ced-6 (via PTB domain).
messages: Involved in programmed cell death, also called apoptosis, in both somatic and germ cells (PubMed:11163239, PubMed:6857247, PubMed:1936965, PubMed:15744306, PubMed:16740477, PubMed:18351800, PubMed:26598553, PubMed:27650246, PubMed:12944970). Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse (PubMed:15744306). Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation (PubMed:16740477, PubMed:18351800). Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria (PubMed:18606143).
messages: NPXY motif thought to be involved in signal transduction that activates the cell corpse internalization process.
messages: Phosphorylation of Tyr-1019, within the YXXL motif, is thought to initiate phagosomal formation.
messages: phagosome membrane

6239:CELE K10B2.2
gene id: 6239:CELE_K10B2.2
uniprot id: Q09991
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE K07F5.4
gene id: 6239:CELE_K07F5.4
uniprot id: D6R8W4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y69H2.10
gene id: 6239:CELE_Y69H2.10
uniprot id: H2L2K9
uniprot id: L8E6Z8
uniprot id: Q9U1U0
names: Subcellular Location Annotation
messages: Secreted

6239:CELE AH6.14
gene id: 6239:CELE_AH6.14
uniprot id: Q09212
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE K07C11.5
gene id: 6239:CELE_K07C11.5
uniprot id: Q21265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor.
messages: Secreted

6239:CELE Y48C3A.18
gene id: 6239:CELE_Y48C3A.18
uniprot id: A5HWA9
uniprot id: G2HK06
uniprot id: Q9NAF8
names: Similarity
messages: Belongs to the SUA5 family.

6239:CELE R07E3.1
gene id: 6239:CELE_R07E3.1
uniprot id: Q21810
uniprot id: Q2L6U9
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F55C5.8
gene id: 6239:CELE_F55C5.8
uniprot id: Q20822
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), srpa-72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with srpa-72 (By similarity). Srpa-68/srpa-72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9 (By similarity). Within the SRP complex, interacts (via C-terminus) with srpa-72 (via N-terminus) (By similarity).
messages: The N-terminus is required for RNA-binding.
messages: nucleolus

6239:CELE T03F1.2
gene id: 6239:CELE_T03F1.2
uniprot id: P91428
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Extends the life span.
messages: Mitochondrion inner membrane
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE F29B9.9
gene id: 6239:CELE_F29B9.9
uniprot id: Q9GYI3
uniprot id: U4PM21
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C01H6.6
gene id: 6239:CELE_C01H6.6
uniprot id: Q17586
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: No visible phenotype. Quintuple knockout with cnnm-1, cnnm-2, cnnm-3 and cnnm-5 results in a reduced lifespan and 100% sterility.
messages: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-5 to regulate Mg(2+) homeostasis.

6239:CELE T24H10.4
gene id: 6239:CELE_T24H10.4
uniprot id: Q22750
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

6239:CELE B0218.2
gene id: 6239:CELE_B0218.2
uniprot id: Q17447
names: Similarity
messages: Belongs to the amidase family.

6239:CELE K08D8.4
gene id: 6239:CELE_K08D8.4
uniprot id: Q21330
uniprot id: Q5CZ40
uniprot id: Q5CZ42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y39A3B.2
gene id: 6239:CELE_Y39A3B.2
uniprot id: Q9N517
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE R90.2
gene id: 6239:CELE_R90.2
uniprot id: Q22032
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE W09H1.5
gene id: 6239:CELE_W09H1.5
uniprot id: O45903
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.
messages: Homodimer.
messages: Mitochondrion

6239:CELE T04B8.3
gene id: 6239:CELE_T04B8.3
uniprot id: O44847
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE Y56A3A.32
gene id: 6239:CELE_Y56A3A.32
uniprot id: K8ESD4
uniprot id: Q9U229
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

6239:CELE F27E5.1
gene id: 6239:CELE_F27E5.1
uniprot id: Q09551
names: Function
names: Similarity
messages: Belongs to the acid ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

6239:CELE F53B6.4
gene id: 6239:CELE_F53B6.4
uniprot id: Q9XVN1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F12F6.9
gene id: 6239:CELE_F12F6.9
uniprot id: Q19368
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE T09B4.8
gene id: 6239:CELE_T09B4.8
uniprot id: O02158
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

6239:CELE T22C1.7
gene id: 6239:CELE_T22C1.7
uniprot id: Q22667
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE K12H4.4
gene id: 6239:CELE_K12H4.4
uniprot id: P34525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS3 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Endoplasmic reticulum membrane
messages: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity).

6239:CELE F13H10.3
gene id: 6239:CELE_F13H10.3
uniprot id: Q19425
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transport is sodium-dependent (By similarity). Transport of leucine, tyrosine and phenylalanine is increased by arginine binding (By similarity).
messages: Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.
messages: Late endosome membrane
messages: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.
messages: Lysosome membrane

6239:CELE ZK816.5
gene id: 6239:CELE_ZK816.5
uniprot id: Q23612
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE F15A2.6
gene id: 6239:CELE_F15A2.6
uniprot id: Q19469
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Expressed in neurons. Colocalizes with strd-1 along the dorsal nerve cord.
messages: Interacts with strd-1 and nab-1.
messages: Pre-synaptic vesicle and active zone proteins fail to be restricted to the axons of motor and sensory neurons. Synaptic vesicles fail to form tight clusters implying aberrant synaptic organization in addition to defects in neuronal polarity. Overexpression causes mislocalization of vesicle proteins to dendrites.
messages: Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.
messages: Synapse

6239:CELE F49E10.2
gene id: 6239:CELE_F49E10.2
uniprot id: H2L060
uniprot id: Q20599
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

6239:CELE K07B1.3
gene id: 6239:CELE_K07B1.3
uniprot id: O01883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE Y105C5B.2
gene id: 6239:CELE_Y105C5B.2
uniprot id: A0A078BQP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in AQR, PQR and URX sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F35H10.1
gene id: 6239:CELE_F35H10.1
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F13H10.2
gene id: 6239:CELE_F13H10.2
uniprot id: Q19427
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Divalent metal cations. Binds 3 Mg(2+) or Mn(2+) ions per subunit.
messages: Homodimer.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Mediates the hydrolysis of some nucleoside diphosphate derivatives (PubMed:10873676).

6239:CELE F48E3.3
gene id: 6239:CELE_F48E3.3
uniprot id: Q9GPA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

6239:CELE F28C10.3
gene id: 6239:CELE_F28C10.3
uniprot id: Q19858
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE C34E10.1
gene id: 6239:CELE_C34E10.1
uniprot id: P46576
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
messages: Belongs to the SAM50/omp85 family.
messages: Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure.
messages: May play a role in the maintenance of the structure of mitochondrial cristae.
messages: Mitochondrion outer membrane

6239:CELE Y69E1A.3
gene id: 6239:CELE_Y69E1A.3
uniprot id: Q9XW34
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F45F2.9
gene id: 6239:CELE_F45F2.9
uniprot id: E1B6Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

6239:CELE F15G9.5
gene id: 6239:CELE_F15G9.5
uniprot id: Q10037
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C37C3.6
gene id: 6239:CELE_C37C3.6
uniprot id: O76840
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the papilin family.
messages: Expression is first detected is intestinal primordium at the embryonic stage 16 dpc followed by expression in future head neurons and head muscle cells at the comma and 1.5-fold stages (PubMed:20805556). Expressed in larvae and adults (PubMed:19297413, PubMed:20805556).
messages: Involved in pharynx morphogenesis probably by remodeling the basement membrane.
messages: Localizes to the basement membranes of the gonad primordium, pharynx and intestine (at protein level) (PubMed:19297413). Expressed in head and CAN neurons, coelomocytes, body-wall muscles and anal depressor and sphincter and stomatointestinal muscles (PubMed:19297413, PubMed:20805556). Expressed Isoform a: is expressed in body wall muscles and distal cell tips (PubMed:19297413). Isoform b: expressed in embryonic muscles (PubMed:19297413).
messages: Plays a role in embryogenesis, the second phase of distal cell tip migration and is required for distribution of the metalloproteinase, mig-17, during organogenesis.
messages: Plays a role in post embryonic distal cell tip migration (PubMed:19297413). Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo (PubMed:11076767).
messages: basement membrane

6239:CELE K12H6.1
gene id: 6239:CELE_K12H6.1
uniprot id: G4SCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F35E8.11
gene id: 6239:CELE_F35E8.11
uniprot id: G5EE89
names: Similarity
messages: Belongs to the FAX family.

6239:CELE T25C8.2
gene id: 6239:CELE_T25C8.2
uniprot id: O45815
names: Similarity
messages: Belongs to the actin family.

6239:CELE F41C6.5
gene id: 6239:CELE_F41C6.5
uniprot id: Q20270
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K10B2.5
gene id: 6239:CELE_K10B2.5
uniprot id: Q09994
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Enriched in adults.
messages: Localizes to the surface of the rachis.
messages: Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis.

6239:CELE R04D3.12
gene id: 6239:CELE_R04D3.12
uniprot id: Q9U399
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE K08B4.6
gene id: 6239:CELE_K08B4.6
uniprot id: G5EDZ9
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the cystatin family.
messages: Cysteine protease inhibitor which inhibits members of the peptidase C1 family (PubMed:12704112, PubMed:15664654). Does not inhibit asparaginyl endopeptidase (PubMed:15664654). May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation (PubMed:24001183).
messages: Expressed in embryos, larvae and adults (at protein level). Expression transiently increases prior to the larval L2/L3, L3/L4 and L4/adult molts.

6239:CELE M02A10.2
gene id: 6239:CELE_M02A10.2
uniprot id: A0A1C3NSR3
uniprot id: D3YT08
uniprot id: H2KYE6
uniprot id: U4PSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

6239:CELE C30C11.4
gene id: 6239:CELE_C30C11.4
uniprot id: Q05036
names: Disruption Phenotype
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: RNAi-mediated knockdown in a sod-1 mutant background results in increased aggregation of denatured proteins in neurons.

6239:CELE Y75B8A.22
gene id: 6239:CELE_Y75B8A.22
uniprot id: G5EDN3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cohesin complex (PubMed:12827206). Interacts with smc-1, smc-3, scc-1 and scc-3 (PubMed:12827206).
messages: Belongs to the timeless family.
messages: Expression is increased during late postembryonic development (PubMed:10550049). In embryos, there is diffuse nuclear expression at interphase, but this reduces by the metaphase-anaphase transition (PubMed:12827206). There is diffuse expression in pre-meiotic germline nuclei as the nuclei enter meiotic prophase and later in the diplotene and diakinesis phases of prophase (PubMed:12827206).
messages: Nucleus
messages: Plays an important role in chromosome cohesion during both mitosis and meiosis (PubMed:12827206). In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion (PubMed:12827206). It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase (PubMed:12827206). Implicated in influencing either the stability or loading of meiotic-specific cohesin subunit, rec8 (PubMed:12827206). Controls cell cycle exit and cell fusion to prevent the premature differentiation into adult cells (PubMed:15691769). Specifically, regulates hypodermal seam cell identity (PubMed:15691769).
messages: RNAi-mediated knockdown is embryonic lethal (PubMed:12827206). In germline cells, aberrant segregation of chromosomes is observed during both mitosis and meiosis, resulting in aneuploidy (PubMed:12827206). There is a weaker mitosis phenotype in somatic tissues (PubMed:12827206). Weak seam cell differentiation capacity during the L4 larval development stage, including 30% increased seam cell fusion and reduced cell cycle exit (PubMed:15691769). RNAi-mediated knockdown increases the survival rate and partially restores alae formation of let-7 n2853 mutants at 20 dgrees Celsius (PubMed:15691769).

6239:CELE ZK354.9
gene id: 6239:CELE_ZK354.9
uniprot id: P91569
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F58B4.1
gene id: 6239:CELE_F58B4.1
uniprot id: Q7JLI1
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in excretory cell and in amphid and phasmid sheath glia.
messages: Metalloprotease.
messages: Secreted

6239:CELE H19N07.2
gene id: 6239:CELE_H19N07.2
uniprot id: G3MU79
uniprot id: G3MU80
uniprot id: G3MU81
uniprot id: G3MU82
uniprot id: G3MU83
uniprot id: N1NSD8
uniprot id: N1NSE3
uniprot id: N1NTD2
uniprot id: N1NTD8
uniprot id: N1NTI7
uniprot id: N1NTJ2
uniprot id: N1NV07
uniprot id: N1NVB4
uniprot id: O45623
uniprot id: O45624
uniprot id: Q7JKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Hydrolase that deubiquitinates target proteins. May play a role in regulating the levels of endogenous siRNA biogenesis (PubMed:32338603).
messages: Nucleus

6239:CELE K11H3.1
gene id: 6239:CELE_K11H3.1
uniprot id: A7LPE5
uniprot id: A7LPE6
uniprot id: P34517
uniprot id: Q7JMU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homodimer.

6239:CELE C17A2.1
gene id: 6239:CELE_C17A2.1
uniprot id: O16538
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F32B5.8
gene id: 6239:CELE_F32B5.8
uniprot id: G5EGP8
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C1 family.
messages: Cytoplasmic granule
messages: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:14630920). Probably, required for the degradation of the old cuticle (PubMed:14630920).
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:14630920, PubMed:16857685). In larvae, only expressed in hypodermis and cuticle (at protein level) (PubMed:14630920, PubMed:16857685). Expressed in the ecdysed cuticle during molting (at protein level) (PubMed:16857685). Expression transiently increases during early embryonic stages and prior to the larval L2/L3, L3/L4 and L4/adult molts (PubMed:14630920, PubMed:16857685).
messages: Expressed in hypodermis, cuticle and pharynx (at protein level) (PubMed:14630920, PubMed:16857685). Expressed in germ cells, developing oocytes, sheath cells surrounding germ cells and oocytes, and in the eggshell (at protein level) (PubMed:16857685). Not expressed in sperm (PubMed:16857685).
messages: RNAi-mediated knockdown causes an arrest at the 50-cell embryonic stage. The few surviving animals are arrested at the larval L2 to L3 molt with their cuticle remaining attached to the mid-portion of the body. RNAi-mediated knockdown at various larval stages causes severe defects in molting.
messages: Secreted
messages: The disulfide bridge formed between Cys-38 in the propeptide and the active site residue Cys-95 may prevent activation of the zymogen through formation of a reversible covalent bond with the active site residue.

6239:CELE T01D1.4
gene id: 6239:CELE_T01D1.4
uniprot id: P91416
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Cytoplasm
messages: Nucleus
messages: Probable inactive acireductone dioxygenase.
messages: This enzyme lacks one or more conserved metal-binding sites. It may be non-functional.

6239:CELE C10C5.5
gene id: 6239:CELE_C10C5.5
uniprot id: Q17900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

6239:CELE Y42H9B.2
gene id: 6239:CELE_Y42H9B.2
uniprot id: Q9N3X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sidekick family.
messages: Cell adhesion protein.
messages: Membrane

6239:CELE Y49E10.4
gene id: 6239:CELE_Y49E10.4
uniprot id: Q9XTU8
names: Similarity
messages: Belongs to the protein disulfide isomerase family.

6239:CELE C16A3.9
gene id: 6239:CELE_C16A3.9
uniprot id: P51404
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

6239:CELE T21D12.4
gene id: 6239:CELE_T21D12.4
uniprot id: O16785
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the parvin family.
messages: Expressed from 1.5 stage embryos, mostly within the muscle cells (PubMed:12781130, PubMed:23283987). In adult hermaphrodites, expressed in the attachments of other muscles, including the uterine, anal depressor, anal sphincter, and vulval muscles, as well as in the spermatheca and the distal tip cells (PubMed:12781130). Expressed in mechanosensory receptor neurons ALML/R, PLML/R, AVM, and PVM (PubMed:12781130). Localizes at body wall muscle attachments (PubMed:12781130, PubMed:23283987).
messages: In mutant embryos, abnormal accumulation of cpna-1 into large foci in body wall muscle cells (PubMed:23283987). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308).
messages: Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112 (PubMed:12781130, PubMed:23283987). Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells (PubMed:12781130, PubMed:23283987). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles (PubMed:16495308).
messages: M line
messages: May interact (via calponin-homology (CH) 2 domain) with pat-4 (via kinase domain) (PubMed:12781130). May form a complex with unc-112 and pat-4 (PubMed:12781130). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: Perikaryon
messages: The calponin-homology (CH) domains are essential for its function during attachment assembly and the interaction with pat-4.
messages: axon
messages: cytoskeleton

6239:CELE D1005.2
gene id: 6239:CELE_D1005.2
uniprot id: Q18910
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

6239:CELE F52A8.6
gene id: 6239:CELE_F52A8.6
uniprot id: A0A1D3PCL3
uniprot id: A0A1D3PCM1
uniprot id: Q19143
names: Domain
names: Function
names: Similarity
messages: Atypical Ras-like protein that may act as a regulator of NF-kappa-B activity.
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
messages: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Lys and Val residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

6239:CELE F02E9.2
gene id: 6239:CELE_F02E9.2
uniprot id: P92186
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lin-28 family.
messages: Cleavage by caspase ced-3 during larval development probably induces lin-28 degradation.
messages: Component of a complex at least containing lep-2, lin-28 and the long non-coding RNA lep-5, which mediates the degradation of lin-28.
messages: Cytoplasm
messages: Expressed at the first larval stage (L1) in several cell types including hypodermis, muscle, neurons and seam cells (PubMed:9054503, PubMed:11884032, PubMed:16122423, PubMed:16139228, PubMed:26811380, PubMed:31264582, PubMed:30956008, PubMed:21471153). Also expressed in the tail tip and pharynx at the L1 stage (PubMed:26811380). Down-regulated at L2, and absent from L3 and L4 (PubMed:9054503, PubMed:11884032, PubMed:16122423, PubMed:16139228, PubMed:26811380, PubMed:31264582, PubMed:30956008, PubMed:21471153).
messages: Heterochronic protein which controls the choice of stage specific cell fates (PubMed:9054503, PubMed:6494891, PubMed:2702689, PubMed:2628162, PubMed:1916265, PubMed:7671811, PubMed:8625405, PubMed:8756295, PubMed:8756296, PubMed:9477318, PubMed:9649524, PubMed:10706289, PubMed:12871707, PubMed:15073154, PubMed:16139228). Regulates the timing of the second larval stage events (L2 events) in the hypodermis (PubMed:2702689, PubMed:2628162). May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3 (PubMed:10706289, PubMed:12871707, PubMed:16139228). Through this regulatory role, controls the timing of the sexual maturation of the nervous system (PubMed:31264582). Also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153). Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008). Plays a role in controlling the seam cell number during larval stages (PubMed:21471153, PubMed:28602583). Plays a role in vulval development (PubMed:28602583).
messages: Negatively regulated by the miRNA lin-4 which causes degradation of the mRNA encoding this protein. This requires a lin-4 complementary element (LCE) in the 3'-UTR of the mRNA encoding this protein. Also negatively regulated independent of lin-4 and this is counteracted by the action of lin-14. Positively regulated by TGF-beta signaling.
messages: RNAi-mediated knockdown in a ced-3 and ain-1 double mutant background reduces the percentage of animals with developmental defects including impaired egg-laying and production of ectopic seam cells. RNAi-mediated knockdown results in the precocious onset of tail tip retraction at the L3 larval stage resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:26811380, PubMed:30956008). RNAi-mediated knockdown suppresses the male tail tip morphogenesis defects of mutants for the long non-coding RNA lep-5 (PubMed:30956008).

6239:CELE R08C7.4
gene id: 6239:CELE_R08C7.4
uniprot id: Q21841
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE R07G3.1
gene id: 6239:CELE_R07G3.1
uniprot id: Q05062
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in the intestine and seam cells.
messages: Highest levels at the embryonic stage, decreasing progressively during development, except for an increase at the L3 stage (PubMed:8514766). Expressed in hypodermal cells during elongation throughout the second phase of embryogenesis (PubMed:8824291).
messages: Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3 (PubMed:11412996, PubMed:11412997). Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291). During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419). May play a role in controlling canal length and in maintaining Golgi and ER stability during excretory canal elongation, probably downstream of ccm-3, which may regulate its activity and expression levels (PubMed:25743393). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Involved in toca-1 and toca-2-mediated protein trafficking controlling the recycling of endocytic cargo protein mig-14 to the Golgi apparatus (PubMed:25775511). Plays a role in male tail tip morphogenesis (PubMed:21408209). Together with kpc-1 and chin-1, plays a role in guiding axons from neurons, including AIY interneurons, into the nerve ring (PubMed:28846083).
messages: RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown in distal tip cells (DTC) causes additional turns during their migration (PubMed:19023419). RNAi-mediated knockdown in addition, causes a truncation of excretory canals associated with the formation of cysts and a reduced distribution of Golgi and ER components along the excretory canal length (PubMed:25743393). RNAi-mediated knockdown results in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space, and accumulation of endocytic cargo protein mig-14 in late endosomes and expansion of recycling endosomes that express toca-1 and toca-2 (PubMed:19798448, PubMed:25775511). RNAi-mediated knockdown enhances the axon guidance defects in glia and sublateral neurons of the kpc-1 gk mutant, in which non-commissural interneurons AIY fail to extend dorsally and enter the nerve ring (PubMed:28846083).
messages: Recycling endosome
messages: The GTP-bound, but not the GDP-bound, form binds to the p21-activated kinase (pak-1) (PubMed:8824291). Interaction with par-6 required for activation of the par-3/par-6/pkc-3 complex (PubMed:11412997). Interacts with toca-1 and toca-2 (PubMed:25775511). May interact with unc-89 (via DH and PH domains); the interaction does not stimulate GTPase activity in vitro (PubMed:18801371).

6239:CELE T19A6.3
gene id: 6239:CELE_T19A6.3
uniprot id: A5PEW7
uniprot id: Q9XXN3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: May form with the serine/threonine protein phosphatase scpl-2 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May play a role in nuclear membrane dynamics being crucial for early development of the embryo.
messages: Membrane
messages: Nucleus membrane
messages: RNAi-mediated knockdown results in the formation of two nuclei in each daughter cell following the first embryonic division.

6239:CELE Y39B6A.29
gene id: 6239:CELE_Y39B6A.29
uniprot id: F3Y5S6
uniprot id: Q9NEU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE B0495.1
gene id: 6239:CELE_B0495.1
uniprot id: Q09213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F44B9.7
gene id: 6239:CELE_F44B9.7
uniprot id: P34428
names: Subunit
messages: Interacts with mdt-28.

6239:CELE Y38A8.3
gene id: 6239:CELE_Y38A8.3
uniprot id: A0A0S4XR45
uniprot id: A0A0S4XRS7
uniprot id: Q23238
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 64% of embryos arrest in between late gastrulation and epidermal morphogenesis with failures in embryogenesis occurring during late gastrulation, epidermal enclosure and elongation. RNAi-mediated knockdown results in arrest in 29% of embryos which display a range of embryonic abnormalities including increased bulge formation (humpback phenotype), epidermal enclosure defects where the ventral cleft fails to close during embryogenesis, impeded or inhibited ventral neuroblast cell migration and irregular cell shape and positioning. Knockdown also results in failure of the catenin-cadherin complex, specifically the cadherin protein, hmr-1 to localize to adherens junctions, but to accumulate along the basolateral membrane of the cell.
messages: Belongs to the peptidase C48 family.
messages: First expressed mid-gastrulation, at the 200-cell stage of embryogenesis with expression increasing during epidermal morphogenesis. Also expressed in epidermal cells and also in the underlying neuroblasts during embryonic development.
messages: Nucleus
messages: Protease that catalyzes two essential functions in the smo-1 pathway: processing of full-length smo-1 to their mature forms and deconjugation of smo-1 from targeted proteins (By similarity). May deconjugate smo-1 from the cadherin protein hmr-1 and plays a role in its recruitment to and the maintenance of adherens junctions (PubMed:26412237). Required for epidermal morphogenesis during embryonic development (PubMed:26412237).
messages: cytosol

6239:CELE Y48B6A.2
gene id: 6239:CELE_Y48B6A.2
uniprot id: Q9U2A8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

6239:CELE Y45F10A.4
gene id: 6239:CELE_Y45F10A.4
uniprot id: O62461
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

6239:CELE H02I12.1
gene id: 6239:CELE_H02I12.1
uniprot id: O45599
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization.
messages: RNAi-mediated knockdown causes the zygote to exit the spermatheca with a pinched morphology and to leave a trailing section behind. Zygotes have a fragmented chitin eggshell with an accumulation of chitin at one end of the embryo, causing polyspermy. In unfertilized oocytes, disrupts the homogenous distribution of cortical chitin synthase chs-1, pseudophosphatase egg-3 and kinase mbk-2 and causes the loss of egg-1 and egg-2 cell membrane localization resulting in their premature accumulation in cytoplasmic puncta.
messages: extracellular matrix

6239:CELE C32E12.2
gene id: 6239:CELE_C32E12.2
uniprot id: P91119
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.

6239:CELE F29C4.6
gene id: 6239:CELE_F29C4.6
uniprot id: O76365
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
messages: Required for normal germline maturation and for viability. Viable at 20 degrees Celsius. At a higher temperature (25 degrees Celsius), the hatched eggs progress through the L1-L4 larval stages with kinetics similar to those of wild type but present an important delay in germline maturation. Whereas gravid wild-type worms are present 53 hours after hatching, germline maturation are still ongoing in the mutant after 66 hours, and the first adults containing eggs are observed 75 hours after hatching, when a large number of new L1 are already present in the wild type. Strikingly, the eggs that finally appeared in the mutant display aberrant morphology and size resulting in both low progeny and high mortality.

6239:CELE T27F7.4
gene id: 6239:CELE_T27F7.4
uniprot id: G5EDN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

6239:CELE F23B2.3
gene id: 6239:CELE_F23B2.3
uniprot id: O45402
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F20G4.3
gene id: 6239:CELE_F20G4.3
uniprot id: G5EBY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

6239:CELE K12C11.4
gene id: 6239:CELE_K12C11.4
uniprot id: O44997
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Beginning in the L3 stage, animals display striking and progressive defects in morphology of the epidermis and cuticle in several body regions, particularly in the nose, tail, vulva, and the dorsal midline in the region of the posterior pharyngeal bulb (PubMed:19164535, PubMed:27661253). The cuticle in these regions becomes up to 5-10 times thicker than the wild-type, at the expense of underlying epidermis (PubMed:19164535, PubMed:27661253). Up-regulates innate immune responses to damage (PubMed:19164535). Decreases starvation-induced autophagy (PubMed:17785524). Disorganization and hyper-stabilization of epidermal microtubules and reduced microtubule growth rates (PubMed:27661253). Treatment with a microtubule stabilizing drug, paclitaxel, results in enhanced epidermal morphology defects (PubMed:27661253). In a ptrn-1 mutant background, suppression of the epidermal morphology defects (PubMed:27661253).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
messages: Expressed in epidermis, muscles and neurons.
messages: Interacts with ptrn-1.
messages: Negative regulator of epidermal barrier repair and innate immune responses to wounding (PubMed:19164535, PubMed:27661253). The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1 (PubMed:27661253). In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA (PubMed:28087624). Appears to act downstream of or in parallel to muscarinic signaling in the regulation of autophagy (PubMed:17785524).
messages: Present from late embryogenesis onwards.
messages: cytoskeleton
messages: cytosol

6239:CELE E03H4.10
gene id: 6239:CELE_E03H4.10
uniprot id: O17741
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F55G1.4
gene id: 6239:CELE_F55G1.4
uniprot id: Q20849
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the RZZ complex composed of rod-1, czw-1 and zwl-1 (PubMed:18765790). Interacts (via N-terminus) with NDC80 complex component ndc-80 (PubMed:24231804).
messages: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:11590237, PubMed:18765790). Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation (PubMed:18765790, PubMed:19109417). Plays a role in nuclear envelope breakdown (PubMed:19109417). Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18765790, PubMed:24231804). The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790, PubMed:24231804). To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804). The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804). Required for embryonic development (PubMed:11590237, PubMed:18765790, PubMed:19109417).
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:11590237, PubMed:18765790, PubMed:19109417). RNAi-mediated knockdown results in defects in mitosis which include the formation of chromatin bridges in between sister chromatids during anaphase (PubMed:11590237). There is also defective chromosome segregation, premature spindle pole separation and incorrectly attached kinetochores (PubMed:18765790). In addition, localization of the spindly-like protein spdl-1 and the other Rzz complex components czw-1 and zwl-1 to the kinetochore is abolished (PubMed:18765790).
messages: kinetochore
messages: spindle

6239:CELE C55B6.1
gene id: 6239:CELE_C55B6.1
uniprot id: H2KZG4
names: Similarity
messages: Belongs to the FGGY kinase family.

6239:CELE M142.5
gene id: 6239:CELE_M142.5
uniprot id: Q21541
names: Similarity
messages: Belongs to the LSM12 family.

6239:CELE Y73F8A.21
gene id: 6239:CELE_Y73F8A.21
uniprot id: J7SEZ3
uniprot id: Q9NA51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F13G3.11
gene id: 6239:CELE_F13G3.11
uniprot id: Q95QL2
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

6239:CELE C47A10.5
gene id: 6239:CELE_C47A10.5
uniprot id: O45307
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DAMOX/DASOX family.
messages: Expressed in the intestinal cells, hypodermis and in unidentified cells in the head in adult hermaphrodites.
messages: Expression detected in the intestinal cells from 3-fold stage embryo to adult stages, and also in the hypodermis and in unidentified cells in the head from larval to adult stages.
messages: Mutant worms have decreased egg-laying capacity at 20 degrees Celsius and decreased hatching rate and smaller brood size at 25 degrees Celsius. Mutant worms have high D-Asp and D-Glu content at both egg and young adult stage but do not show any change in physical appearance. Mutant worms also exhibit decreased fertilization rates.
messages: Peroxisome
messages: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells.

6239:CELE T12D8.1
gene id: 6239:CELE_T12D8.1
uniprot id: G5EGI1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE W01C9.4
gene id: 6239:CELE_W01C9.4
uniprot id: Q23116
names: Function
names: Similarity
messages: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

6239:CELE Y38F2AR.9
gene id: 6239:CELE_Y38F2AR.9
uniprot id: Q95XS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

6239:CELE B0280.3
gene id: 6239:CELE_B0280.3
uniprot id: P41994
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

6239:CELE F57A10.5
gene id: 6239:CELE_F57A10.5
uniprot id: O17898
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed from embryogenesis onwards with high expression during the larval stages of development, peaking at the L3 stage and decreasing at the L4 stage of larval development. Ubiquitously expressed, but expression in seam cells begins in embryonic precursors soon after fertilization and is most prominent in larval stages of development. Expression is also prominent in the germ line during the L1 stage of larval development. Also expressed in pharyngeal gland cells, VC4 and VC5 neurons, and in the hermaphrodite uterine vulval uv1 cells.
messages: Nucleus
messages: Orphan nuclear receptor (Potential). Required for embryonic and larval morphogenesis and probably for seam cell positioning and migration.
messages: RNAi-mediated knockdown results in arrest at the two-fold stage of embryogenesis in the majority of embryos. These embryos have incomplete ventral closure and morphological defects including elongation defects, and either absent or irregularly placed seam cells in the head and tail regions. Surviving larvae also exhibit morphological defects and contain vacuoles.

6239:CELE F46G10.3
gene id: 6239:CELE_F46G10.3
uniprot id: Q20481
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Expression starts at the 100 cell stage during embryogenesis and is expressed throughout development until adulthood.
messages: Interacts with pyc-1, pcca-1 and mccc-1.
messages: Mitochondrion
messages: Mitochondrion matrix
messages: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance (PubMed:23438705). Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2 (PubMed:28820880). Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked (PubMed:28820880).
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
messages: Ubiquitously expressed with high expression in the pharynx, body wall muscles and gonad. Strong expression in a subset of non-neuronal cells in the head.

6239:CELE T14A8.1
gene id: 6239:CELE_T14A8.1
uniprot id: Q22472
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ric-3 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in pharyngeal muscles, body wall muscles and in most neurons.
messages: Interacts with the deg-3/des-2 acetylcholine receptor.
messages: Required for maturation and cell surface expression of acetylcholine receptors.

6239:CELE B0213.10
gene id: 6239:CELE_B0213.10
uniprot id: O44655
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F58H7.2
gene id: 6239:CELE_F58H7.2
uniprot id: O45089
names: Similarity
messages: Belongs to the amidase family.

6239:CELE Y37E3.8
gene id: 6239:CELE_Y37E3.8
uniprot id: Q9BKU5
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

6239:CELE C26E6.6
gene id: 6239:CELE_C26E6.6
uniprot id: P49404
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Mitochondrion

6239:CELE Y47D3B.1
gene id: 6239:CELE_Y47D3B.1
uniprot id: Q9XX03
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y42A5A.4
gene id: 6239:CELE_Y42A5A.4
uniprot id: E1NZ10
uniprot id: E1NZ11
uniprot id: Q9U2H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Modulates cilium assembly.
messages: Specifically expressed in head and tail ciliated sensory neurons.
messages: cilium

6239:CELE T13C2.6
gene id: 6239:CELE_T13C2.6
uniprot id: H2KZX4
uniprot id: Q7JP80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R03H10.6
gene id: 6239:CELE_R03H10.6
uniprot id: Q9GYL9
names: Similarity
messages: Belongs to the replication factor A protein 1 family.

6239:CELE H06O01.1
gene id: 6239:CELE_H06O01.1
uniprot id: G5ED07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

6239:CELE C17A2.2
gene id: 6239:CELE_C17A2.2
uniprot id: O16536
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE T20G5.6
gene id: 6239:CELE_T20G5.6
uniprot id: P34579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Cytoplasmic vesicle membrane
messages: Involved in the uptake of GABA into the synaptic vesicles.

6239:CELE F35F10.6
gene id: 6239:CELE_F35F10.6
uniprot id: Q9GYU1
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE W01D2.5
gene id: 6239:CELE_W01D2.5
uniprot id: Q9XU63
uniprot id: U4PEW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter.

6239:CELE F58E1.6
gene id: 6239:CELE_F58E1.6
uniprot id: H2L039
uniprot id: Q9TZH0
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

6239:CELE K11G12.5
gene id: 6239:CELE_K11G12.5
uniprot id: G5EE96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:9733776). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, by supplying the substrates for the different metabolic processes (By similarity).
messages: Mitochondrion inner membrane

6239:CELE F40G9.2
gene id: 6239:CELE_F40G9.2
uniprot id: Q9TZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

6239:CELE T15H9.3
gene id: 6239:CELE_T15H9.3
uniprot id: Q10007
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the gland cells of the pharynx and weakly in the pharyngeal neuron.
messages: Nucleus
messages: Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding (PubMed:18927627). Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes (PubMed:18927627). Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source (PubMed:18927627). Exhibits pharyngeal gland-specific positive autoregulation activity (PubMed:17049341).

6239:CELE ZK938.4
gene id: 6239:CELE_ZK938.4
uniprot id: Q23674
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C50F2.9
gene id: 6239:CELE_C50F2.9
uniprot id: G5EGC4
names: Developmental Stage
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all larval and adult stages but not in pre-hatching embryos.
messages: Expressed in the pharynx and body wall muscle.
messages: Secreted

6239:CELE ZC308.1
gene id: 6239:CELE_ZC308.1
uniprot id: O17087
names: Developmental Stage
names: Domain
names: Function
names: RNA Editing
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundant in embryos, fourth larval stages and adults.
messages: Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
messages: Cytoplasm
messages: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline.
messages: Germline-specific.
messages: In contrast to other poly(A) RNA polymerases, lacks any RNA-binding domain. RNA-binding is mediated through its interaction with gld-3.
messages: Interacts with gld-3.
messages: Partially edited. RNA editing takes place in most germline-specific transcripts.

6239:CELE D2005.5
gene id: 6239:CELE_D2005.5
uniprot id: Q93413
names: Similarity
messages: Belongs to the helicase family. RLR subfamily.

6239:CELE W04A8.7
gene id: 6239:CELE_W04A8.7
uniprot id: G5EGM3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF1 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed in embryo.
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic arrest at the 100-cell stage, premature cell division of E2 cells, Ea and Ep, severe loss of polymerase II large subunit ama-1 phosphorylation and reduction in the transcription of several embryonic genes.
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-1 (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II (PubMed:14726532). Required for early embryonic development (PubMed:14726532). Essential for embryonic transcription of several genes (PubMed:14726532).

6239:CELE ZC443.5
gene id: 6239:CELE_ZC443.5
uniprot id: Q23323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE T07G12.4
gene id: 6239:CELE_T07G12.4
uniprot id: G8JZM6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C45B11.1
gene id: 6239:CELE_C45B11.1
uniprot id: G5EFU0
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Despite the gene name, this is not the ortholog of vertebrate PAK2.
messages: Divalent cations such as magnesium or manganese.
messages: Expressed in pharynx, vulva and spermatheca. Unlike other p21-activated kinases, expression is not detected in neurons.
messages: Low level of embryonic lethality (< 15 percent) which is suppressed by simultaneous RNAi-mediated knockdown of max-2 (PubMed:19797046). In pak-1 and pak-2 double mutants, defects in embryogenesis and L1 stage lethality. The few animals reaching adulthood are smaller but have normal ventral cord commissural motoneuron axonal guidance and are relatively coordinated (PubMed:17050621, PubMed:19797046).
messages: Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration.

6239:CELE K08F8.4
gene id: 6239:CELE_K08F8.4
uniprot id: P90925
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine (PubMed:18460651, PubMed:10928216). Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan (PubMed:10928216). Plays a role in the biosynthesis of a melanin-like cuticle pigment (PubMed:18460651).
messages: Cytoplasm
messages: Expressed during all larval stages and in adult animals (at protein level).
messages: Expressed in the seam cells of the lateral hypodermis, in the ventral hypodermis and in the hyp7 hypodermal syncytium, in hypodermal cells in the tail and in body wall muscle cells (at protein level).
messages: Homotetramer.
messages: Inhibited by tetrahydrobiopterin. Unlike its mammalian orthologs, pah-1 does not exhibit allosteric binding behavior for phenylalanine.
messages: Reduced L-phenylalanine hydroxylation. Lack of a yellow-orange pheomelanine-like pigment in the cuticle. Higher cuticle resistance to physical or chemical disintegration factors or oxidizing environments. Increase in superoxide dismutase activity. Increased life span. In a bli-3(e767) mutant background, growth arrest in early larval development, severe cuticle abnormalities with large blisters and increased superoxide dismutase activity. RNAi-mediated knockdown together with fah-1 RNAi partially rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072).

6239:CELE B0024.12
gene id: 6239:CELE_B0024.12
uniprot id: Q17427
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

6239:CELE T28C12.1
gene id: 6239:CELE_T28C12.1
uniprot id: O16698
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y45G12B.2
gene id: 6239:CELE_Y45G12B.2
uniprot id: Q9N4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZFPL1 family.
messages: Membrane

6239:CELE M03C11.1
gene id: 6239:CELE_M03C11.1
uniprot id: Q21483
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE W09C5.2
gene id: 6239:CELE_W09C5.2
uniprot id: Q9U334
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

6239:CELE Y43C5A.5
gene id: 6239:CELE_Y43C5A.5
uniprot id: F3Y5P8
uniprot id: G5EEZ5
names: Similarity
messages: Belongs to the thymidine kinase family.

6239:CELE Y54E5A.1
gene id: 6239:CELE_Y54E5A.1
uniprot id: G5EC63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
messages: Membrane

6239:CELE R06B9.3
gene id: 6239:CELE_R06B9.3
uniprot id: O17982
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C55B7.6
gene id: 6239:CELE_C55B7.6
uniprot id: G5EED0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE T10G3.2
gene id: 6239:CELE_T10G3.2
uniprot id: P92019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE K01A6.6
gene id: 6239:CELE_K01A6.6
uniprot id: H9G2T5
uniprot id: Q21077
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F43C1.4
gene id: 6239:CELE_F43C1.4
uniprot id: Q09565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T28F3.3
gene id: 6239:CELE_T28F3.3
uniprot id: Q9XUC4
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.
messages: By cholesterol.
messages: Highly expressed in developing spermatids (at the protein level) (PubMed:29879108). Expressed in the germline (PubMed:29879108).
messages: Membrane
messages: Reduced brood size, but the majority of hermaphrodites are sterile and lay a large number of unfertilized oocytes (PubMed:29879108). Defective spermatid activation (PubMed:29879108). Double knockout with spe-4 results in failed spermatocyte division (PubMed:29879108). Double knockout with spe-6 results in suppression of the premature spermatid activation phenotype of the single spe-6 (hc163) mutant (PubMed:29879108).
messages: Zinc transporter which regulates intracellular zinc levels (PubMed:29879108). Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function (PubMed:29879108). Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm (PubMed:29879108). The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization (PubMed:29879108).

6239:CELE K02E11.1
gene id: 6239:CELE_K02E11.1
uniprot id: Q21145
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE F42H10.5
gene id: 6239:CELE_F42H10.5
uniprot id: P34418
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Defective cessation of distal tip cell migration from the dorsal muscle towards the mid-body during gonadal development. RNAi-mediated knockdown of cacn-1 in mig-39 null animals results in a strong overshoot phenotype in which anterior and posterior distal tip cells. RNAi-mediated knockdown of Rac GTPase, Rac-2, in double mig-39 and either ced-10 or mig-2 (which are also Rac GTPases) null animals, suppresses the overshoot phenotype in mig-39 null animals.
messages: Expressed in distal tip cells and in germline cells.
messages: Expressed in the nucleus of distal tip cells until larval stage L4 when expression decreases onwards to late adulthood.
messages: Nucleus
messages: Regulates the timing and orientation of distal tip cell migration during gonadal development. May act in parallel to cacn-1 and Rac GTPases to control the anterior and posterior migration of distal tip cells.

6239:CELE F13E9.11
gene id: 6239:CELE_F13E9.11
uniprot id: K8ERZ3
uniprot id: K8ESG8
names: Similarity
messages: Belongs to the TMEM121 family.

6239:CELE Y49E10.1
gene id: 6239:CELE_Y49E10.1
uniprot id: Q9XTT9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex (Probable). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). Interacts with elt-2 (PubMed:30265660).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:30265660). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:30265660). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides (By similarity). In addition, regulates gene expression in response to bacterial infection (PubMed:30265660). Binds to the GATA transcription factor elt-2 to control its transcriptional activity and thus the expression of elt-2-dependent genes in response to infection by Gram-negative bacteria such as P.aeruginosa (PubMed:30265660).
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown at the L4 stage of larval development inhibits activity of the proteasome (PubMed:30265660). RNAi-mediated knockdown at the L4 larval stage also results in increased mortality and transcription of immune genes containing the elt-2 binding motif when exposed to Gram-negative bacteria such as P.aeruginosa (PubMed:30265660). RNAi-mediated knockdown at this stage, furthermore, prevents the recovery of P.aeruginosa infected animals treated with the antibiotic streptomycin (PubMed:30265660).

6239:CELE K11G9.2
gene id: 6239:CELE_K11G9.2
uniprot id: Q23009
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE C30F8.4
gene id: 6239:CELE_C30F8.4
uniprot id: Q95YD4
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
messages: Expressed in body wall muscles and some neurons in the head.
messages: Has apparently no tyrosine kinase activity in vitro when expressed in mammalian cells.
messages: RNAi-mediated knockdown causes no obvious phenotype.

6239:CELE ZK742.2
gene id: 6239:CELE_ZK742.2
uniprot id: Q23088
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UVSSA family.
messages: Chromosome
messages: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage (PubMed:27043179). TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity).

6239:CELE T01C3.10
gene id: 6239:CELE_T01C3.10
uniprot id: E0AHC1
uniprot id: G5EEH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

6239:CELE F45F2.13
gene id: 6239:CELE_F45F2.13
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C34F11.3
gene id: 6239:CELE_C34F11.3
uniprot id: D7SFL2
uniprot id: H2KZ18
uniprot id: H2KZ19
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

6239:CELE Y54G9A.4
gene id: 6239:CELE_Y54G9A.4
uniprot id: Q9XWH3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y37A1A.4
gene id: 6239:CELE_Y37A1A.4
uniprot id: A0A061ADZ4
uniprot id: B3GWD4
uniprot id: C6KRP1
uniprot id: G5EDU9
uniprot id: G5EE35
uniprot id: O45268
names: Similarity
messages: Belongs to the RIPOR family.

6239:CELE T27A1.4
gene id: 6239:CELE_T27A1.4
uniprot id: O17274
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK354.7
gene id: 6239:CELE_ZK354.7
uniprot id: P91567
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C10F3.3
gene id: 6239:CELE_C10F3.3
uniprot id: O16880
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

6239:CELE K06A9.3
gene id: 6239:CELE_K06A9.3
uniprot id: P91363
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C30A5.3
gene id: 6239:CELE_C30A5.3
uniprot id: P34349
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOB1/phocein family.
messages: Golgi stack membrane
messages: May play a role in membrane trafficking, specifically in membrane budding reactions.
messages: Membrane
messages: perinuclear region

6239:CELE M03D4.1
gene id: 6239:CELE_M03D4.1
uniprot id: G5EC43
uniprot id: G5EG83
uniprot id: Q8MQ04
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE ZC404.3
gene id: 6239:CELE_ZC404.3
uniprot id: Q23288
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SPE39 family.
messages: Cytoplasm
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Expressed in spermatocytes and spermatids (at protein level).
messages: Expressed in the embryonic testis.
messages: Interacts with vps-33.1 and vps-33.2 (PubMed:19109425). Associates with the homotypic fusion and vacuole protein sorting (HOPS) complex, impaired by vps-33.2 (By similarity).
messages: Late endosome
messages: Mutants produce spermatocytes that complete meiosis but do not usually form functional. Show defective vesicular biogenesis during spermatogenesis with morphogenesis failure of the specialized Golgi-derived fibrous body-membranous organelle (FB-MO) complexes. Show disrupted processing of endocytosed proteins in oocytes and coelomocytes.
messages: Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membranous organelle (FB-MO) complexes. Required for the processing of internalized proteins in oocytes and coelomocytes.
messages: Recycling endosome

6239:CELE F14B8.7
gene id: 6239:CELE_F14B8.7
uniprot id: Q95QL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE C30C11.2
gene id: 6239:CELE_C30C11.2
uniprot id: Q04908
names: Function
names: Similarity
names: Subunit
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S3 family.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).

6239:CELE F14F7.3
gene id: 6239:CELE_F14F7.3
uniprot id: O17807
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE Y45F10D.12
gene id: 6239:CELE_Y45F10D.12
uniprot id: O45946
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL18 family.
messages: Cytoplasm

6239:CELE F52F12.1
gene id: 6239:CELE_F52F12.1
uniprot id: Q9U539
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Membrane
messages: Transports organic cations such as tetraethylammonium (TEA). Displays a broad substrate specificity.

6239:CELE F57C7.3
gene id: 6239:CELE_F57C7.3
uniprot id: P50605
uniprot id: Q8I4H9
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell junction
messages: Cell surface
messages: Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2 (PubMed:25344071). Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts (PubMed:26022293). Promotes the axon guidance of D-type motor neurons (PubMed:24066155).
messages: Cell surface proteoglycan.
messages: Cytoplasm
messages: Disrupted mitotic spindle orientation of the ABar blastomere division axis, orientating parallel rather than orthogonally to the division axis of AB derived cells ABpr and ABal (PubMed:25344071). Reduced mig-5 accumulation at the cell contact sites between the ABar and C blastomere cells (PubMed:25344071). Irregular positioning of the AQR and PQR neurons in larva at the L4 stage (PubMed:26022293).
messages: Expressed from the one-cell stage of embryogenesis onwards.
messages: Membrane
messages: The cytoplasmic domain is required for correct mitotic spindle orientation and internalization of sdn-1.

6239:CELE Y47D3B.5
gene id: 6239:CELE_Y47D3B.5
uniprot id: Q6EUT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C34F6.8
gene id: 6239:CELE_C34F6.8
uniprot id: O17643
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

6239:CELE Y116F11B.12
gene id: 6239:CELE_Y116F11B.12
uniprot id: C6S3M5
uniprot id: Q8I136
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: Golgi apparatus membrane
messages: Membrane
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE W06A7.4
gene id: 6239:CELE_W06A7.4
uniprot id: H2L2D7
uniprot id: Q23189
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE Y22D7AR.5
gene id: 6239:CELE_Y22D7AR.5
uniprot id: G5EF00
names: Similarity
messages: Belongs to the globin family.

6239:CELE F08G2.6
gene id: 6239:CELE_F08G2.6
uniprot id: Q9XVA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F39B2.8
gene id: 6239:CELE_F39B2.8
uniprot id: O45500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

6239:CELE C34E10.11
gene id: 6239:CELE_C34E10.11
uniprot id: Q95QS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

6239:CELE ZK1098.5
gene id: 6239:CELE_ZK1098.5
uniprot id: P34605
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer. Part of the multisubunit TRAPP (transport protein particle) complex (By similarity).
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Required for the systemic spread of the RNAi response (PubMed:16862146).
messages: cis-Golgi network

6239:CELE T05G5.8
gene id: 6239:CELE_T05G5.8
uniprot id: P34561
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843).
messages: Belongs to the VPS53 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-51, vps-52 and vps-54 (PubMed:21613545).
messages: Endosome membrane
messages: Mutants are viable but display reduced brood size and enlarged lysosomes (PubMed:21613545). Egg-laying defect, slow, but coordinated locomotion, and reduced levels of unprocessed and processed cargo in the motor neuron axon of the dorsal nerve cord (PubMed:27191843).
messages: Perikaryon
messages: Ubiquitously expressed, with particularly strong expression in neuronal cells (PubMed:21613545). Specifically expressed in head and tail neurons and in the pharynx and ventral cord motor neurons (PubMed:27191843).
messages: perinuclear region
messages: trans-Golgi network membrane

6239:CELE C34D4.14
gene id: 6239:CELE_C34D4.14
uniprot id: V6CJX7
uniprot id: V6CL74
uniprot id: V6CLA2
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins (PubMed:24703696, PubMed:21673654). Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision (PubMed:25552605). Negatively regulates glp-1 activity in germline proliferation (PubMed:25552605). May play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis (PubMed:20153198). Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci (PubMed:27669035).
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: Expressed in most tissues, including hypodermis, muscle, intestine, vulva, and neurons.
messages: RNAi-mediated knockdown causes no visible phenotype (PubMed:20153198). RNAi-mediated knockdown in a glp-1(ar202) mutant background causes an increase in the number of sterile animals (PubMed:25552605). RNAi-mediated knockdown in a vab-10(e698) mutant background causes 50 percent larval lethality associated with the detachment of muscles from the epidermis (PubMed:20153198).

6239:CELE M04B2.1
gene id: 6239:CELE_M04B2.1
uniprot id: Q21502
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically. Expressed in all developmental stages; highest in embryos, decreasing during early larval development (L1-L3) until the fourth larval stage (L4) where it increases. Expression in hermaphrodite adults is mostly contained to the germline.
messages: Expressed in somatic cells of embryos, the head, hypodermis and tail of larvae and the germline of adults, including oocytes but not mature sperm and spermatocytes.
messages: Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.
messages: Interacts with hda-1, let-418, lin-1, mog-1, mog-4, mog-5, mog-6, pie-1 and unc-98.
messages: Nucleus
messages: Worms exhibit temperature-dependent arrested elongation of gonadal arms. Mutants raised at 25 degrees C show reduced numbers of descendants of the gonadal precursors Z1 and Z4, while mutants raised at 15 degrees C show wild type gonadal development. Vulval defects are also temperature sensitive. Mutants grown at 20 degrees C showed protruding vulva (80%) and some had pseudovulvae (15%). At 15 degrees C, fewer mutants exhibited everted (36%) or additional small vulvae (7%).

6239:CELE K04G2.2
gene id: 6239:CELE_K04G2.2
uniprot id: Q21221
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the AB hydrolase superfamily. ABHD17 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed in a subset of neurons including AIY, HSN, ADF, AFD, AWC, AWB and NSM, hypodermis, pharyngeal muscle and intestine.
messages: Expressed in larvae and adults.
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (By similarity). Acts in sensory neurons including AWC to regulate starvation-induced thermotaxis plasticity and salt learning behavior.
messages: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization and localization to sensory neuron endings.

6239:CELE B0403.4
gene id: 6239:CELE_B0403.4
uniprot id: Q11067
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Lethal at the early stages of larval development. Arrested larvae are small and display molting defects. RNAi-mediated knockdown results in reduced fecundity, and in induction of the unfolded protein response.
messages: May function as a chaperone that inhibits aggregation of misfolded proteins (By similarity). May negatively regulate the unfolded protein response (UPR) through binding to UPR sensors (PubMed:24508390).

6239:CELE C11D2.7
gene id: 6239:CELE_C11D2.7
uniprot id: Q8MXH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

6239:CELE Y39B6A.14
gene id: 6239:CELE_Y39B6A.14
uniprot id: Q9NEU2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Nucleus
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm (Probable). Required for normal somatic gonad development and for regulation of germline development and proliferation.
messages: Worms exhibit defects in hermaphrodite gonadogenesis and germline proliferation which are associated with a reduction in sheath cell number.

6239:CELE T05H4.13
gene id: 6239:CELE_T05H4.13
uniprot id: O16518
uniprot id: Q86S57
uniprot id: Q8MXJ7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE C25E10.10
gene id: 6239:CELE_C25E10.10
uniprot id: Q18159
names: Subcellular Location Annotation
messages: Secreted

6239:CELE Y116A8C.30
gene id: 6239:CELE_Y116A8C.30
uniprot id: Q9U2S7
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

6239:CELE Y105E8B.4
gene id: 6239:CELE_Y105E8B.4
uniprot id: Q9NF14
names: Function
names: Subunit
messages: Interacts with cul-3.
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

6239:CELE T23G5.6
gene id: 6239:CELE_T23G5.6
uniprot id: Q03615
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging (PubMed:21573134).
messages: Interacts with phosphorylated egl-4. May interact with itself. May be a component of a histone deacetylase complex containing saeg-2, saeg-1 and hda-2.
messages: Nucleus
messages: Ubiquitously expressed.

6239:CELE Y46G5A.26
gene id: 6239:CELE_Y46G5A.26
uniprot id: Q9U2E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE M7.3
gene id: 6239:CELE_M7.3
uniprot id: Q21593
names: Similarity
messages: Belongs to the BicC family.

6239:CELE F29F11.3
gene id: 6239:CELE_F29F11.3
uniprot id: Q19906
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.

6239:CELE R09A1.1
gene id: 6239:CELE_R09A1.1
uniprot id: A0A0K3AY23
uniprot id: O61931
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway (PubMed:17110334, PubMed:20133583). Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G-siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end (PubMed:22102828, PubMed:22548001). Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs (PubMed:22548001). Association with 26G-siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guanine residue at the 5'-end) (PubMed:22102828). May be involved in passenger strand cleavage of target 26G-siRNAs (PubMed:22102828).
messages: Belongs to the argonaute family.
messages: Belongs to the argonaute family. Piwi subfamily.
messages: Cytoplasm
messages: Expressed in embryos and during larval development up to larval stage L2 (PubMed:20133583). Highly expressed in embryos (PubMed:22548001).
messages: Highly expressed in the germline in hermaphrodites.
messages: Interacts with rde-12 (PubMed:24684931). Interacts with rde-10 (PubMed:22542102).

6239:CELE K08D10.7
gene id: 6239:CELE_K08D10.7
uniprot id: Q21319
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE C38C3.9
gene id: 6239:CELE_C38C3.9
uniprot id: O17081
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK970.6
gene id: 6239:CELE_ZK970.6
uniprot id: Q23682
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in both ASEL and ASER neurons during early embryonic stages and becomes specifically expressed in ASER neuron in early larval stage.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses to salt ions mediated by ASE sensory neurons (PubMed:19523832).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE Y51H1A.4
gene id: 6239:CELE_Y51H1A.4
uniprot id: Q9XWJ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

6239:CELE Y40B10A.3
gene id: 6239:CELE_Y40B10A.3
uniprot id: A0A0K3AVA4
uniprot id: Q965W7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R02D3.3
gene id: 6239:CELE_R02D3.3
uniprot id: O44499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

6239:CELE K02D3.2
gene id: 6239:CELE_K02D3.2
uniprot id: Q21130
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

6239:CELE T22H2.6
gene id: 6239:CELE_T22H2.6
uniprot id: Q7JKP2
uniprot id: Q9U362
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

6239:CELE R173.1
gene id: 6239:CELE_R173.1
uniprot id: Q10462
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.
messages: Secreted

6239:CELE C23F12.1
gene id: 6239:CELE_C23F12.1
uniprot id: A0A0K3ASN4
uniprot id: A0A0K3ASN9
uniprot id: A0A0K3AT80
uniprot id: A0A0K3AT86
uniprot id: A0A0K3AVH5
uniprot id: A0A0K3AVH8
uniprot id: A0A0K3AVI4
uniprot id: A0A0K3AW96
uniprot id: A0A0K3AWA2
uniprot id: A0A0K3AYH6
uniprot id: A0A0K3AYI1
uniprot id: D0VWL7
uniprot id: D0VWL8
names: Similarity
messages: Belongs to the filamin family.

6239:CELE F15B9.7
gene id: 6239:CELE_F15B9.7
uniprot id: G5EDK5
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation (PubMed:20876647, PubMed:22442082, PubMed:23376536, PubMed:28846083). Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve ring (PubMed:28846083). Promotes motorneuron development by positively regulating the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord (PubMed:23376536). Plays a role in synaptogenesis by regulating synaptic vesicle accumulation at GABAergic and cholinergic neuromuscular junctions (PubMed:22442082).
messages: Expressed in a region of neuropil around the nerve ring and the ventral cord (at protein level) (PubMed:22442082). Expressed in the head, tail, ventral cord, nerve ring and neurons including HSN neurons (PubMed:20876647). Expressed in DA, VA, and VB and weakly in the DB cholinergic neurons (PubMed:22442082). Not expressed in ventral D-type GABAergic motorneurons (PubMed:22442082).
messages: Expressed throughout development (PubMed:20876647). In embryos, first expressed in neuronal precursor cells during gastrulation (PubMed:20876647). At the comma and 1.5-fold embryonic stage, expressed in neurons in the head, the tail and along the ventral cord (PubMed:20876647). In 1.5-fold stage embryos, expressed in the nerve ring bundle (PubMed:28846083). At the L1 larval stage, expressed in the ventral nerve cord and in a subset of dorsal D-type GABAergic motorneurons (PubMed:22442082, PubMed:23376536). At the L2 larval stage, expressed along the ventral nerve cord (PubMed:23376536). Not expressed in ventral D-type GABAergic motorneurons at the L2 larval stage (PubMed:23376536).
messages: axon
messages: dendrite

6239:CELE C01A2.3
gene id: 6239:CELE_C01A2.3
uniprot id: O02207
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

6239:CELE F28C12.1
gene id: 6239:CELE_F28C12.1
uniprot id: O17842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F23H11.3
gene id: 6239:CELE_F23H11.3
uniprot id: O02642
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

6239:CELE ZK809.2
gene id: 6239:CELE_ZK809.2
uniprot id: Q23598
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

6239:CELE Y73E7A.6
gene id: 6239:CELE_Y73E7A.6
uniprot id: G5EE03
names: Similarity
messages: Belongs to the BLCAP family.

6239:CELE Y22F5A.5
gene id: 6239:CELE_Y22F5A.5
uniprot id: O62416
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 25 family.
messages: Expressed in intestine.
messages: Induced in response to Gram-positive bacterium P.aeruginosa infection and to mitochondrial stress in the intestine (PubMed:25274306). Induced in response to Gram-positive bacterium B.thuringiensis (B-18247) infection (PubMed:21931778).
messages: Involved in resistance to Gram-positive bacteria P.aeruginosa or B.thuringiensis infection.
messages: Lacks conserved active site residues, suggesting it has no catalytic activity.
messages: Reduced survival following bacterium B.thuringiensis (B-18247) infection (PubMed:21931778). RNAi-mediated knockdown causes a reduction in survival following bacterium P.aeruginosa infection (PubMed:25274306).

6239:CELE D2092.5
gene id: 6239:CELE_D2092.5
uniprot id: P91193
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity. In AWA and AWC neurons, plays a role in regulating olfactory adaptation by controlling the forgetting sensory responses to odorants such as diacetyl and isoamyl alcohol (PubMed:28924007). May play a role in regulating daf-7 expression in ASI neurons in response to bacterial small RNAs (PubMed:32908307). In ASI neurons, promotes dauer formation in response to pheromones such as the ascarosides ascr#2 and ascr#3 (PubMed:26976437).
messages: RNAi-mediated knockdown results in defective avoidance behavior in response to P.aeruginosa.
messages: Rough endoplasmic reticulum membrane
messages: Strong expression in many neurons, very weak expression is also detected in others tissues.

6239:CELE Y48G1BM.1
gene id: 6239:CELE_Y48G1BM.1
uniprot id: Q965U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6239:CELE Y39B6A.23
gene id: 6239:CELE_Y39B6A.23
uniprot id: Q8MYN6
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C35A5.4
gene id: 6239:CELE_C35A5.4
uniprot id: Q18471
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE R11H6.1
gene id: 6239:CELE_R11H6.1
uniprot id: O18000
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

6239:CELE Y39A1C.4
gene id: 6239:CELE_Y39A1C.4
uniprot id: G5EDG9
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

6239:CELE T18H9.5
gene id: 6239:CELE_T18H9.5
uniprot id: Q22549
uniprot id: Q6AHN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE F13B9.5
gene id: 6239:CELE_F13B9.5
uniprot id: G5EFD2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Interacts with mek-2.
messages: Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration (PubMed:8521513, PubMed:11882296). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells (PubMed:8521513, PubMed:11882296). In addition, involved in determining vulval precursor cell fate during vulval induction independently of its kinase activity (PubMed:8521514, PubMed:8521513, PubMed:10409742, PubMed:11882296). Plays a role in egg-laying (PubMed:23900546).
messages: The kinase may be catalytically inactive.

6239:CELE C14F11.5
gene id: 6239:CELE_C14F11.5
uniprot id: B0M0L8
uniprot id: H2KYS1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE M01D7.4
gene id: 6239:CELE_M01D7.4
uniprot id: O01969
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

6239:CELE ZK1127.11
gene id: 6239:CELE_ZK1127.11
uniprot id: Q23405
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Expressed maternally.
messages: Heterooligomer of him-14 and msh-5.
messages: Nucleus
messages: Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Together with msh-5 and zhp-3 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells (PubMed:23832114). Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair.
messages: Worms show maternal effect lethality producing 95% inviable progeny from hermaphrodites. A high proportion of those that survive are male. Mutants display severely reduced crossing over, resulting in lack of chiasmata between homologous chromosomes and consequent missegregation.

6239:CELE C29A12.3
gene id: 6239:CELE_C29A12.3
uniprot id: Q27474
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
messages: Nucleus

6239:CELE R07G3.8
gene id: 6239:CELE_R07G3.8
uniprot id: Q09387
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

6239:CELE W09G12.1
gene id: 6239:CELE_W09G12.1
uniprot id: O45203
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE F52C12.6
gene id: 6239:CELE_F52C12.6
uniprot id: B5WWL2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

6239:CELE ZC373.5
gene id: 6239:CELE_ZC373.5
uniprot id: Q23261
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

6239:CELE F33D4.3
gene id: 6239:CELE_F33D4.3
uniprot id: O44185
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: AADGAPLIRF-amide: Inhibits muscle tension in somatic muscle (PubMed:11527423). Acts as a ligand for the npr-22 receptor in vitro (PubMed:16377032). Acts as a ligand for isoform a of the dmsr-1 G-protein coupled receptor in vitro (PubMed:28094002).
messages: APEASPFIRF-amide: Inhibits muscle tension in somatic muscle (PubMed:9070852). Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system (PubMed:16187307). Acts as a ligand for isoform a of the dmsr-1 G-protein coupled receptor in vitro (PubMed:28094002).
messages: Acts as a ligand for isoform a of the dmsr-1 G-protein coupled receptor in vitro.
messages: Acts as a ligand for the npr-22 receptor in vitro. Acts as a ligand for isoform a of the dmsr-1 G-protein coupled receptor in vitro (PubMed:28094002).
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in low levels in adults (PubMed:9685599, PubMed:15236235). Expressed in the ALA neuron in L4 stage larvae (PubMed:27546573).
messages: Expressed in the ASE sensory neurons, the DD motor neurons, the 15, M3 and M5 cholinergic pharyngeal motoneurons, and the ASG, ASK and BAG neurons.
messages: Probable FMRFamide-like neuropeptides (PubMed:28094002, PubMed:16377032). Binds to neuronal receptors such as dmsr-1 to promote sleep in response to cellular stress also known as stress-induced sleep (SIS) (PubMed:28094002). Plays a role in behaviors associated with SIS, acting in concert with the FMRFamide related peptide, flp-24 and neuropeptide-like protein nlp-8 (PubMed:27546573).
messages: Secreted

6239:CELE Y51H4A.3
gene id: 6239:CELE_Y51H4A.3
uniprot id: Q22038
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Cytoplasm
messages: GTP hydrolysis is stimulated by unc-89.
messages: Highest expression during larval development with a peak at L3 and lower levels in the embryo and adult (at protein level).
messages: In larvae and adults, enriched at the tip of the head where the anterior sensory organ is located and in the pharyngeal nerve ring (at protein level). In embryos, enriched at the boundaries of dorsal cells undergoing intercalation, ventral enclosure and elongation.
messages: May interact with unc-89 (via DN and PH domains) (PubMed:18801371). Interacts with bli-3 and memo-1 (PubMed:28085666).
messages: RNAi-mediated knockdown predominantly results in embryonic arrest with surviving embryos developing elongation-defective uncoordinated kinky larvae (PubMed:24016757, PubMed:11687661). Defective ventral migration of P cells leading to defective gonad development (PubMed:11687661). Defective establishment of anterior-posterior cell polarity in one-cell embryos (PubMed:16921365). Abolished cortical contractility in early embryos (PubMed:23064028). RNAi-mediated knockdown results in disorganized myosin thick filaments in the body wall muscles of the few surviving adults, which is characterized by the formation of abnormal myosin heavy chain myo-3 aggregates, V-shaped crossing of A-bands and areas in which the myosin heavy chain is missing (PubMed:18801371). RNAi-mediated knockdown suppresses reactive oxygen species induction and longevity in the memo-1 mutant (PubMed:28085666). Double RNAi-mediated knockdown with memo-1 eliminates the resistance to oxidative stress in the memo-1 single mutant (PubMed:28085666).
messages: Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation (PubMed:24016757). Also required for ventral migration of P cells during larval development (PubMed:11687661). Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development (PubMed:16921365). In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology (PubMed:21387015). In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89 (PubMed:18801371). Association with the oxidase bli-3 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity (PubMed:28085666).
messages: cell cortex
messages: cytoskeleton

6239:CELE F09F7.4
gene id: 6239:CELE_F09F7.4
uniprot id: Q19278
uniprot id: Q8MNT7
names: Function
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.

6239:CELE R06F6.2
gene id: 6239:CELE_R06F6.2
uniprot id: Q09600
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Increased numbers of germ cell corpses (PubMed:18425118, PubMed:18923146). Reduced number of gut granules in the adult intestine (PubMed:24501423). Endosome/lysosome fusion defects in coelomocytes (PubMed:26783301). Double knockout with either sorf-1 or sorf-2 results in larger endosomes and larger lysosomes and thus suppresses the endosome/lysosome fusion defects in coelomocytes in the vps-11 single mutant (PubMed:26783301). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen and large endosomes/lysosomes on the basal side of the cell (PubMed:25273556).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301). Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423, PubMed:25273556). The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25273556). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (By similarity). Possibly has a role in clearance of apoptotic cells during programmed cell death (PubMed:18425118, PubMed:18923146).
messages: Probable core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, which in HOPS further associates with vps-33.1, vps-39 and vps-41 and in CORVET with vps-8 and vps-33.2.

6239:CELE ZC204.4
gene id: 6239:CELE_ZC204.4
uniprot id: P91535
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE T10B9.1
gene id: 6239:CELE_T10B9.1
uniprot id: Q27513
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE C49A1.3
gene id: 6239:CELE_C49A1.3
uniprot id: O17671
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE T05C12.7
gene id: 6239:CELE_T05C12.7
uniprot id: P41988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE Y39G8C.4
gene id: 6239:CELE_Y39G8C.4
uniprot id: Q7YTG4
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE ZC302.2
gene id: 6239:CELE_ZC302.2
uniprot id: Q23256
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the WD repeat WDR5/wds family.
messages: Not required for methylation of histone H3 'Lys-4'.
messages: RNAi-mediated knockdown does not result in detectable defects in histone H3 'Lys-4' di- or tri-methylation in embryos or adults germ cells at 20 or 25 degrees Celsius.

6239:CELE Y75B8A.1
gene id: 6239:CELE_Y75B8A.1
uniprot id: Q9XW88
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the abd-b homeobox family.
messages: Nucleus
messages: Probable transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification (PubMed:10781051, PubMed:21408209). May regulate expression of transcription factor dmd-3 (PubMed:21408209).
messages: RNAi-mediated knockdown in adults has no effect on their F1 progeny, but increases the frequency of posterior morphological abnormalities on a homeobox nob-1 mutant background (PubMed:10781051). However, RNAi-mediated knockdown in L1 larvae causes defects in tail tip morphogenesis, which are exacerbated on a nob-1 mutant background (PubMed:21408209).

6239:CELE ZC196.2
gene id: 6239:CELE_ZC196.2
uniprot id: O01630
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T09A5.3
gene id: 6239:CELE_T09A5.3
uniprot id: P45963
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Forms a homooligomeric channel blocked by alpha-bungarotoxin. The structure is probably pentameric (By similarity).
messages: Postsynaptic cell membrane

6239:CELE C27C12.7
gene id: 6239:CELE_C27C12.7
uniprot id: Q18253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell membrane
messages: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.

6239:CELE F59A1.13
gene id: 6239:CELE_F59A1.13
uniprot id: G5EF35
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F26F4.3
gene id: 6239:CELE_F26F4.3
uniprot id: Q19821
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: In L1 larvae, expressed in vulval precursor cells (VPCs) and Pn.a-derived neurons. In L2 larvae, uniformly expressed in all VPCs. In L3 larvae, expression decreases in all VPCs except P6.p. In L4 larvae, expression decreases in descendants of P5.p, P6.p and P7.p while expression remains high in descendants of P3.p, P4.p and P8.p. In L4 larvae, expressed in the anchor cell and other cells in the somatic gonad.
messages: Membrane
messages: RNAi-mediated knockdown does not affect vulva development. Partially suppresses ectopic vulva formation in a let-60 (n1046) gain-of-function mutant background.
messages: Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs.

6239:CELE ZK287.5
gene id: 6239:CELE_ZK287.5
uniprot id: Q23457
names: Caution
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RING-box family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.
messages: Cytoplasm
messages: Expressed at high levels in eggs and adults, and at low levels in larva.
messages: It is uncertain whether Met-1 or Met-10 is the initiator.
messages: Nucleus
messages: Part of SCF complexes, which consist of a SKP1 or a SKP1-related protein, a cullin protein, and a F-box protein (By similarity). Interacts with csn-1 and csn-6.
messages: Strongly expressed in the gonads of hermaphrodite animals.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.

6239:CELE Y94H6A.7
gene id: 6239:CELE_Y94H6A.7
uniprot id: A7WK41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

6239:CELE M18.2
gene id: 6239:CELE_M18.2
uniprot id: Q21557
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of a dynein complex.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6239:CELE F28G4.1
gene id: 6239:CELE_F28G4.1
uniprot id: O17851
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE B0379.4
gene id: 6239:CELE_B0379.4
uniprot id: Q8T3G2
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Both RNAi-mediated knockdown of isoform a and of isoform b decreases egg laying triggered by serotonin treatment (PubMed:18337465). Causes no visible defects in unc-89 and cpna-1 localization in body wall muscles (PubMed:19244614, PubMed:23283987).
messages: Expressed in pharyngeal, vulval and body wall muscles.
messages: Inhibited by beryllium trifluoride (BeF(3-)) and tetrafluoroaluminate (AlF(4-)) but not by sodium fluoride (NaF) or sodium orthovanadate (Na3VO4).
messages: M line
messages: May also use Mn(2+).
messages: May interact (via phosphatase domain) with cpna-1 (PubMed:23283987). Isoform a and isoform b may interact with lim-9 (via LIM zinc-binding domain) (PubMed:19244614). Isoform a and isoform b may interact (via FCP1 homology domain) with unc-89 (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and protein kinase domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and protein kinase domain 2); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 protein kinase domains (PubMed:18337465, PubMed:19244614).
messages: Phosphatase which may play a role in the egg laying muscles.

6239:CELE Y39A1A.23
gene id: 6239:CELE_Y39A1A.23
uniprot id: Q95Q27
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rad9 family.
messages: May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.
messages: Putative component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of hpr-9, mrt-2 and hus-1 (Probable).
messages: RNAi-mediated knockdown disrupts hus-1 localization to the nucleus.

6239:CELE T10B9.2
gene id: 6239:CELE_T10B9.2
uniprot id: Q27514
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE C45G7.2
gene id: 6239:CELE_C45G7.2
uniprot id: O76358
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
messages: Expressed in pharyngeal muscle cell pm3, nerve ring and intestine.
messages: Has bacteriolytic activity against Gram-positive bacteria (By similarity). May play a role in resistance to Gram-positive bacterium S.aureus infection (PubMed:24882217).
messages: Induced by Gram-positive bacterium M.nematophilum CBX102 infection but not by Gram-negative bacterium P.aeruginosa PAO1 infection (PubMed:27525822). Induced by Gram-positive bacterium S.aureus infection (PubMed:24882217).
messages: Simultaneous RNAi-mediated knockdown of lys-5 results in a reduction in survival following S.aureus infection.

6239:CELE Y22D7AR.8
gene id: 6239:CELE_Y22D7AR.8
uniprot id: Q86MI7
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE C54F6.8
gene id: 6239:CELE_C54F6.8
uniprot id: O16443
names: Subcellular Location Annotation
messages: Nucleus

6239:KEF34 p10
gene id: 6239:KEF34_p10
uniprot id: G4XR16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE Y38F1A.8
gene id: 6239:CELE_Y38F1A.8
uniprot id: Q9XWM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

6239:CELE C08F8.4
gene id: 6239:CELE_C08F8.4
uniprot id: H9G2W5
uniprot id: H9G2W6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K02F2.4
gene id: 6239:CELE_K02F2.4
uniprot id: O44984
names: Similarity
messages: Belongs to the peptidase C48 family.

6239:CELE M176.2
gene id: 6239:CELE_M176.2
uniprot id: Q21549
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

6239:CELE R08D7.1
gene id: 6239:CELE_R08D7.1
uniprot id: P30640
names: Similarity
messages: Belongs to the CWC26 family.

6239:CELE F32D8.3
gene id: 6239:CELE_F32D8.3
uniprot id: Q19964
names: Subcellular Location Annotation
messages: Secreted

6239:CELE B0213.6
gene id: 6239:CELE_B0213.6
uniprot id: O44662
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Antimicrobial peptides that have antifungal activity against D.coniospora. Has weak antibacterial activity against Gram-positive bacteria M.luteus and Gram-negative E.coli.
messages: Belongs to the YARP (YGGW-amide related peptide) family.
messages: Expressed in hypoderm.
messages: Expressed in precomma stasge embryos.
messages: Secreted
messages: Strongly up-regulated upon D.coniospora infection.

6239:CELE M60.2
gene id: 6239:CELE_M60.2
uniprot id: Q9GYM9
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

6239:CELE F56A8.6
gene id: 6239:CELE_F56A8.6
uniprot id: O45577
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F54E12.1
gene id: 6239:CELE_F54E12.1
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T28D9.2
gene id: 6239:CELE_T28D9.2
uniprot id: Q10021
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus
messages: Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites.
messages: RNA-mediated interference (RNAi) of rsp-5/rsp-6 resulted in fertile animals that exhibit excessive sperm and delayed oocyte production, and sterile animals that develop morphological abnormalities of somatic gonads.

6239:CELE Y71F9B.7
gene id: 6239:CELE_Y71F9B.7
uniprot id: Q9N2L7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in oocytes.
messages: Expressed in the early stages of embryogenesis.
messages: Interacts (via POLO box domain) with mex-5 and mex-6 (PubMed:18199581, PubMed:22018922). Interacts (via POLO box domain) with him-8 (via N-terminus); the interaction mediates plk-2 recruitment to the pairing region of X chromosomes during meiosis (PubMed:22018922). Interacts with sun-1 (PubMed:22018921). May interact with nicotinic acetylcholine receptor (PubMed:15990870).
messages: Mutants are viable and fertile but about 30-percent of the progeny die at the embryonic stage. Surviving adults are mostly male (PubMed:22018922). Impaired chromosome pairing and synapsis during meiotic prophase. Asymmetric disassembly of the synaptonemal complex fails at the diplotene stage. Partial mis-segregation of chromosomes. Increased germline apoptosis (PubMed:22018922). Simultaneous knockdown of plk-1 and plk-2 causes a loss in pie-1 polarization in the 1-cell embryo, an increased association with the oocyte pronuclei and a decrease in pie-1 degradation in embryonic somatic cells (PubMed:18199581).
messages: Nucleus
messages: Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase (PubMed:22018922, PubMed:22018921). Promotes the localization of brc-1 to the short arm of homologous chromosomes during meiotic prophase I (PubMed:30383754). Regulates the formation of sun-1 patches along the nuclear envelope (PubMed:22018922, PubMed:22018921). Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis (PubMed:22018922). Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions (PubMed:18199581). Plays a role in nicotinic acetylcholine receptor-mediated sensitivity to nicotine but not levamisole (PubMed:15990870). Regulates motility (PubMed:15990870).
messages: centrosome
messages: kinetochore

6239:CELE F21F8.11
gene id: 6239:CELE_F21F8.11
uniprot id: O01537
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC373.7
gene id: 6239:CELE_ZC373.7
uniprot id: Q23263
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C51E3.6
gene id: 6239:CELE_C51E3.6
uniprot id: Q18771
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C09G5.1
gene id: 6239:CELE_C09G5.1
uniprot id: Q09453
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily.
messages: Cell membrane
messages: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Contributes to the generation of inhibitory postsynaptic currents.
messages: Pentamer.
messages: Postsynaptic cell membrane
messages: Synapse

6239:CELE T09E11.10
gene id: 6239:CELE_T09E11.10
uniprot id: O02310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C48B4.10
gene id: 6239:CELE_C48B4.10
uniprot id: P34364
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C45G7.3
gene id: 6239:CELE_C45G7.3
uniprot id: O76357
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
messages: Expressed in pharynx grinder muscle pm7, isthmus marginal cell mc2 and pharyngeal muscle cell pm5, intestinal cells and at lower levels in coelomocytes and epidermis (PubMed:27525822). Expressed at low levels in intestine (PubMed:20617181).
messages: Expression levels are low throughout larval stages and then increase in adults. Intestinal expression starts at the L1 larval stage, declines at the L2 larval stage and increases again in L4 larvae and adults. Highly expressed in the intestinal lumen of dauer larvae and, old and no longer self-fertile adults.
messages: Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria.
messages: Induced in the intestine by Gram-positive bacteria M.nematophilum CBX102 and UV336 and M.luteus DMS20030 infection but not by Gram-negative bacterium P.aeruginosa PAO1 infection (PubMed:27525822). Induced in the intestine, pharynx and vulva by Gram-positive bacterium S.aureus infection (PubMed:20617181). Induced by Gram-positive bacterium B.subtilis (PubMed:20617181). Induced by starvation (PubMed:27525822).
messages: Late endosome lumen
messages: Lysosome lumen
messages: Recycling endosome lumen
messages: Secreted
messages: Slight reduction in brood size. 24 percent reduction in lifespan which is further reduced upon M.nematophilum CBX102 bacterial infection. Impaired food digestion characterized by the accumulation of unlysed E.coli in the intestine. Accumulation of unlysed bacteria is stronger upon M.nematophilum CBX102 infection.

6239:CELE B0454.1
gene id: 6239:CELE_B0454.1
uniprot id: G5EDW7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a synthetic multivulva class A (synMuvA) protein and redundantly inhibits lin-3/EGF expression to prevent inappropriate vulva induction.
messages: Belongs to the lin-8 family.
messages: Interacts with lin-35 (via C-terminus).
messages: Nucleus
messages: Temperature-sensitive multivulva phenotype in a lin-15B n2245 or lin-52 n771 mutant background.
messages: Widely expressed throughout development, with particularly prominent expression in the germline and in neuronal nuclei of the head (at protein level).

6239:CELE C05C8.7
gene id: 6239:CELE_C05C8.7
uniprot id: O16315
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

6239:CELE F55C10.2
gene id: 6239:CELE_F55C10.2
uniprot id: Q20805
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y41C4A.19
gene id: 6239:CELE_Y41C4A.19
uniprot id: Q86MP2
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y87G2A.13
gene id: 6239:CELE_Y87G2A.13
uniprot id: Q9U1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

6239:CELE F42G4.3
gene id: 6239:CELE_F42G4.3
uniprot id: Q9U3F4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Expressed in neurons and body wall muscle (PubMed:18094057, PubMed:23427270, PubMed:25252943). Expressed in pharyngeal, enteric and uterine muscles and in spermatheca (PubMed:25252943).
messages: Expressed in neurons and muscle throughout development.
messages: Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus) (PubMed:23427270). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development (PubMed:25252943).
messages: Interacts with dyc-1 (PubMed:18094057, PubMed:23427270). Interacts with glh-1 and glh-3 (PubMed:12435362).
messages: M line
messages: Nucleus
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform a.
messages: RNAi-mediated knock-down of isoform a in a dys-1/hlh-1 double mutant background reduces muscle degeneration.
messages: The LIM domains are sufficient for the role in PLM synaptogenesis.
messages: axon
messages: cytoskeleton
messages: focal adhesion

6239:CELE C48A7.1
gene id: 6239:CELE_C48A7.1
uniprot id: G5EG02
uniprot id: Q8MQA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

6239:CELE R173.4
gene id: 6239:CELE_R173.4
uniprot id: Q8MPY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Secreted

6239:CELE F43E2.4
gene id: 6239:CELE_F43E2.4
uniprot id: O02086
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

6239:CELE T05H4.4
gene id: 6239:CELE_T05H4.4
uniprot id: O16522
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

6239:CELE K01D12.6
gene id: 6239:CELE_K01D12.6
uniprot id: Q21096
names: Similarity
messages: Belongs to the mitoguardin family.

6239:CELE C05E11.1
gene id: 6239:CELE_C05E11.1
uniprot id: Q17667
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Expressed in cell bodies along the ventral cord around the pharynx and the tail both in larvae and adults. Also expressed in muscles and hypodermal cells.
messages: Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1.
messages: Worms exhibit increased resistance to aldicarb indicative of an affect on neurotransmission but equal sensitivity to levamisole which specifically inhibits the postsynapse. Mutants also show mislocalized rab-3 and snb-1 proteins.

6239:CELE E02H1.3
gene id: 6239:CELE_E02H1.3
uniprot id: Q09524
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of transfer RNAs.

6239:CELE E03H4.3
gene id: 6239:CELE_E03H4.3
uniprot id: O17747
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C26H9A.1
gene id: 6239:CELE_C26H9A.1
uniprot id: B2MZD0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Expressed in hypodermal cells in L1 larvae (PubMed:11441002). No expressed in embryos (PubMed:11441002).
messages: Expressed in uterus.
messages: Membrane
messages: RNAi-mediated knockdown does not affect embryonic or larval development.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE K07A12.3
gene id: 6239:CELE_K07A12.3
uniprot id: P90921
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase g subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE F17A9.2
gene id: 6239:CELE_F17A9.2
uniprot id: O16216
names: Similarity
messages: Belongs to the CWF19 family.

6239:CELE K05C4.6
gene id: 6239:CELE_K05C4.6
uniprot id: O44326
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the beta-catenin family.
messages: Component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:25850673). Interacts with hmr-1; the interaction is direct (PubMed:10952315, PubMed:25850673, PubMed:26412237). May interact with hmp-1 (PubMed:11560894). Interacts with frk-1 (PubMed:20805471).
messages: Epidermal cells.
messages: Present in all embryonic blastomeres at early stages of development (at protein level).
messages: Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567). Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions (PubMed:26412237).
messages: Worms have strong elongation defects (PubMed:9531567). RNAi-mediated knockdown results in failure of cadherin protein hmr-1 to localize to adherens junctions, but results in its accumulation along the basolateral membrane of the cell (PubMed:26412237).
messages: adherens junction

6239:CELE F44F4.5
gene id: 6239:CELE_F44F4.5
uniprot id: Q20405
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein sra family.
messages: Expressed in the URX sensory neuron, the ALA interneuron and in additional interneurons, pharyngeal neurons and muscle.
messages: Membrane

6239:CELE T22F3.8
gene id: 6239:CELE_T22F3.8
uniprot id: Q94305
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y34D9A.10
gene id: 6239:CELE_Y34D9A.10
uniprot id: Q9BL83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

6239:CELE ZK973.5
gene id: 6239:CELE_ZK973.5
uniprot id: Q9N4M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE W09C5.4
gene id: 6239:CELE_W09C5.4
uniprot id: Q9U333
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE C18F3.4
gene id: 6239:CELE_C18F3.4
uniprot id: H2KYW5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the threefold embryonic stage, expressed asymmetrically in one of the two AWC neurons (PubMed:19204119). A subset of embryos show bilateral expression in AWC neurons, but this declines after larval stage L1 (PubMed:19204119).
messages: Expressed widely, including gut, the amphid sheath glial cells, and head and tail neurons including AWC, ASE, and ASH (PubMed:19204119). Expressed in AWC (ON) olfactory neuron but not AWC (OFF) (PubMed:19204119, PubMed:31767767).
messages: Nucleus
messages: RNAi-mediated knockdown leads to misexpression of markers of the asymmetric state of AWC neurons.
messages: Transcriptional regulator which binds DNA consensus sequence 5'-CCTTAAC-3' (PubMed:19204119, PubMed:31767767). Plays a role in establishing and maintaining asymmetric cell fates in chemosensory AWC neurons during larval neuronal development (PubMed:19204119, PubMed:20713521, PubMed:31767767). This is achieved by repressing the expression of multiple AWC (OFF) genes, including srsx-3 and hlh-11 in the AWC (ON) neuron (PubMed:19204119). Activates expression of sox-2 in the AWC (ON) neuron (PubMed:31767767).

6239:CELE F12F6.7
gene id: 6239:CELE_F12F6.7
uniprot id: Q19366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer with subunits of 125 kDa and 50 kDa.
messages: Nucleus
messages: The function of the small subunit is not yet clear.

6239:CELE F55A4.1
gene id: 6239:CELE_F55A4.1
uniprot id: Q94241
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

6239:CELE D1014.8
gene id: 6239:CELE_D1014.8
uniprot id: Q18919
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CoREST family.
messages: Loss of function results in a suppression of sel-12 mutant phenotypes, possibly by up-regulating hop-1 expression (PubMed:12411496). Double knockout with lin-35 results in defects in growth, vulval morphogenesis, somatic gonad development and fertility (PubMed:17070797).
messages: Nucleus
messages: Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12381669). Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones (PubMed:12381669). Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation (PubMed:17070797).
messages: Probably part of a large repressor complex. Interacts with histone demethylase spr-5/lsd-1.

6239:CELE K04C1.6
gene id: 6239:CELE_K04C1.6
uniprot id: G5EEF5
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE Y119D3B.12
gene id: 6239:CELE_Y119D3B.12
uniprot id: H2L0S8
uniprot id: Q8IAB4
names: Similarity
messages: Belongs to the Luc7 family.

6239:CELE R74.7
gene id: 6239:CELE_R74.7
uniprot id: Q22031
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

6239:CELE F33H2.5
gene id: 6239:CELE_F33H2.5
uniprot id: O62218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

6239:CELE F35E8.13
gene id: 6239:CELE_F35E8.13
uniprot id: G5EEU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE W06A7.3
gene id: 6239:CELE_W06A7.3
uniprot id: B5U8N2
uniprot id: G5ECZ2
uniprot id: G5EDI2
uniprot id: Q23188
uniprot id: Q7JLB0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE ZK1320.4
gene id: 6239:CELE_ZK1320.4
uniprot id: Q09653
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Membrane

6239:CELE Y39A3CL.5
gene id: 6239:CELE_Y39A3CL.5
uniprot id: Q8IAA9
names: Similarity
messages: Belongs to the peptidase C2 family.

6239:CELE F26A3.1
gene id: 6239:CELE_F26A3.1
uniprot id: Q93595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

6239:CELE Y43D4A.4
gene id: 6239:CELE_Y43D4A.4
uniprot id: Q9NF27
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T24B1.1
gene id: 6239:CELE_T24B1.1
uniprot id: P90970
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May be involved in maintaining Golgi structure and in intra-Golgi transport.

6239:CELE F57B9.2
gene id: 6239:CELE_F57B9.2
uniprot id: Q20937
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CNOT1 family.
messages: Component of the CCR4-NOT complex at least composed of ccf-1, ccr-4 and let-711, which is required for germ cell development in hermaphrodites (PubMed:23843623). Within the complex interacts with ccf-1 and ccr-4; the interactions are direct (PubMed:23843623).
messages: Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.
messages: Highly expressed in embryos.
messages: Highly expressed in the germline of hermaphrodites.
messages: Nucleus
messages: RNAi-mediated knockdown results in sterility and the production of inviable embryos which are osmotically sensitive, exhibit nuclear rotation defects and irregular positioning of the mitotic spindle which is located towards the posterior or lateral cortex during anaphase (PubMed:23843623, PubMed:16971515). RNAi-mediated knockdown may also result in a reduced brood size and larval lethality (PubMed:23843623). RNAi-mediated knockdown disrupts the arrangement and differentiation of oocytes in the proximal region and as a result small oocyte-like cells arrange in several rows in the germline (PubMed:23843623). RNAi-mediated knockdown reduces the levels of ccf-1, but does not alter ccr-4 levels (PubMed:23843623). RNAi-mediated knockdown results in reduced global poly(A) tail deadenylation (PubMed:23843623). RNAi-mediated knockdown results in reduces degradation of nos-2 mRNA, impairs the recruitment of lsm-1 and decreases the number of patr-1-positive granules in somatic blastomeres (PubMed:18692039).
messages: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:23843623, PubMed:28204614). Positively regulates the accumulation of the CCR4-NOT complex component ccr-1 (PubMed:23843623). Within the complex promotes germ cell development and fertility in hermaphrodites (PubMed:23843623). Additional complex functions may be a consequence of its influence on mRNA expression (By similarity). Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs (By similarity). Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex (Probable). Acts as a transcriptional repressor (By similarity). Represses the ligand-dependent transcriptional activation by nuclear receptors (By similarity). In embryos, plays a role in female pronucleus and mitotic spindle positioning during the first cleavage divisions after fertilization (PubMed:16971515). This may partly be through negatively regulating the accumulation of zyg-9 at the centrosome (PubMed:16971515). Negatively regulates the formation of long astral microtubules in developing embryos (PubMed:16971515). Required for the stabilization and degradation of maternal mRNAs such as nos-2 in somatic blastomeres (PubMed:18692039).

6239:CELE W04H10.3
gene id: 6239:CELE_W04H10.3
uniprot id: A0A0M7RE93
uniprot id: F8Y420
uniprot id: H2L0K3
names: Similarity
messages: Belongs to the TRIM/RBCC family.

6239:CELE K03D3.10
gene id: 6239:CELE_K03D3.10
uniprot id: Q94124
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation (PubMed:19023419).
messages: RNAi-mediated knockdown causes distal tip cells (DTC) to make extra turns in approximately 20 percent of animals during the last phase of gonad morphogenesis.

6239:CELE C18E3.2
gene id: 6239:CELE_C18E3.2
uniprot id: O02101
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMARCD family.
messages: Chromosome
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes (Probable). The canonical complex contains a catalytic subunit swsn-4, core subunits swsn-1 and swsn-5, and accessory subunits swsn-3, swsn-6, phf-10, dpff-1, swsn-9 and either ham-3/swsn-2.1 or swsn-2.2 (Probable).
messages: Expression begins at the gastrulation stage (PubMed:23457234). Expressed broadly at L1 larval stage except in the intestine (PubMed:23457234). Expression decreases in the subsequent larval stages and is absent in adults (PubMed:23457234).
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Probably regulates vulva development through the let-60/Ras pathway (PubMed:26739451). Involved in nuclear reassembly after mitosis and recruitment of nuclear envelope protein, mel-28, to the nuclear periphery in the early embryo and in the adult germline (PubMed:26739451). Involved in gonadogenesis (PubMed:26739451, PubMed:24402584).
messages: Nucleus envelope
messages: Some knockouts exhibit maternal-effect embryonic or larval lethality (PubMed:24402584). Germ lines are smaller (PubMed:26739451). RNAi-mediated knockdown reduces brood size (PubMed:26739451). Simultaneous knockouts of ham-3 do not survive beyond the L2 larval stage (PubMed:24402584). Simultaneous RNAi-mediated knockdown of ham-3 at the L1 larval stage causes sterility, while at the L3 larval stage, causes embryonic lethality for the progeny (PubMed:26739451). The sterile animals resulting from simultaneous RNAi-mediated knockdown of ham-3 at the L1 larval stage develop smaller germ lines (PubMed:26739451). Simultaneous RNAi-mediated knockdown of ham-3 also results in vulva protrusion and ectopic expression of egl-17 in cells derived from the vulval precursor cells P5.p and P7.p (PubMed:26739451).
messages: nucleoplasm

6239:CELE VC5.2
gene id: 6239:CELE_VC5.2
uniprot id: Q9TYU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K10C2.4
gene id: 6239:CELE_K10C2.4
uniprot id: Q94272
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the FAH family.
messages: Fumarylacetoacetase involved in the tyrosine degradation pathway.
messages: Highly expressed in the intestine and the hypodermis.
messages: RNAi-mediated knockdown from hatching results in stunted growth, reduced fertility, progressive destruction of the intestine by adulthood characterized by the thinning of the intestinal wall and loss of intracellular lipid droplets, which eventually culminates in lethality (PubMed:18227072). RNAi-mediated knockdown results in activation of cellular stress pathways, and thus the intestinal damage is most likely due to activation of oxidative stress responses and ER stress responses in the intestine (PubMed:18227072). The reduced fertility phenotype is enhanced in response to exogenous tyrosine or homogentisic acid (PubMed:18227072). RNAi-mediated knockdown together with tatn-1 RNAi, hpd-1 RNAi or hgo-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072).

6239:CELE F22E10.5
gene id: 6239:CELE_F22E10.5
uniprot id: G5EC09
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

6239:CELE ZK256.1
gene id: 6239:CELE_ZK256.1
uniprot id: G5EDU1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C43E11.4
gene id: 6239:CELE_C43E11.4
uniprot id: G5EDF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

6239:CELE Y37E11C.1
gene id: 6239:CELE_Y37E11C.1
uniprot id: Q01630
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons (PubMed:1468626, PubMed:11493519, PubMed:16236031, PubMed:22101643, PubMed:25358863, PubMed:30045855). Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins (PubMed:22101643). This is achieved in part by regulating the localization of kinesin-like protein unc-104 (PubMed:22101643). In neurons without a distal microtubule-organizing center (MTOC), also controls the organization of microtubules in dendrites (PubMed:30254025). During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Rac GTPases ced-10 and mig-2 to inhibit growth cone filopodial protrusion mediated by the unc-6/netrin receptor unc-40-unc-5 (PubMed:25371370). Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and by restricting plus-end microtubule accumulation in the growth cone (PubMed:30045855). Probably downstream of mab-20/Sema2a and mab-20 receptor plx-2, regulates the guidance of DD/VD neuron axons by modulating fln-1 interaction with F-actin which results in the remodeling of the actin cytoskeleton (PubMed:25358863). In hermaphrodites, involved in sex myoblast (SM) migration by regulating the gonad-dependent repulsion of SMs (PubMed:10993679).
messages: Expressed in L1 larval stage and in adults (at protein level) (PubMed:16236031). Isoform a: Expressed in L1 larval stage and in adults (at protein level) (PubMed:16236031).
messages: Expressed in ventral cord and nerve ring (at protein level) (PubMed:16236031). Isoform a: Expressed in nerve ring (at protein level) (PubMed:16236031, PubMed:22101643). Expressed in the nervous system, two amphid socket cells and weakly in non-neuronal pharyngeal cells (PubMed:11493519).
messages: In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of gap junctions.
messages: In neurons, required for the polarized sorting of axonal proteins (PubMed:22101643). In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of gap junctions (PubMed:27015090). Plays a role in locomotion and egg-laying (PubMed:22101643).
messages: Isoform a: Probable monomer (PubMed:16236031). Isoform b: Probable homodimer (PubMed:16236031). Isoform c: Probable homodimer (PubMed:16236031). Probable heterodimer composed of isoform b and isoform c (PubMed:16236031). Interacts with unc-14 and kinesin-1 motor complex light chain klc-1; both interactions regulate unc-33 neurite localization (PubMed:16236031). Interacts with fln-1 (via calponin-homology (CH) domains and filamin repeat 18-19) (PubMed:25358863). Isoform c: Interacts with vab-8 isoform a (PubMed:27015090).
messages: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.
messages: axon
messages: dendrite

6239:CELE Y75B8A.24
gene id: 6239:CELE_Y75B8A.24
uniprot id: Q9XW63
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

6239:CELE F27C1.2
gene id: 6239:CELE_F27C1.2
uniprot id: P91284
uniprot id: Q6BEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6239:CELE F46B6.7
gene id: 6239:CELE_F46B6.7
uniprot id: Q20448
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the ZNF277 family.
messages: By microRNA let-7; probably by direct interaction.
messages: Probable transcription factor.
messages: RNAi-mediated knockdown suppresses lethality and sterility caused by let-7 mutant background.

6239:CELE R186.3
gene id: 6239:CELE_R186.3
uniprot id: Q22013
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE K02G10.6
gene id: 6239:CELE_K02G10.6
uniprot id: Q7Z139
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals deficient in HYL-2 show inability to adapt to oxygen deprivation as a result from the loss of ceramide synthase function.
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Catalyzes the acylation of sphingoid bases to form ceramides. Sphingolipids from Caenorhabditis elegans contain exclusively isosphingoid bases. Exhibits substrate preference for fatty acyl-coA chains containing 20 to 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by HYL-2, and seems to be affected by a pathway that is parallel to that involving daf-2.
messages: Membrane
messages: Strong expression in the gut, the posterior bulb of the pharynx, the hypoderm, and unidentified cells of the head and the tail.

6239:CELE Y87G2A.10
gene id: 6239:CELE_Y87G2A.10
uniprot id: Q9NA26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I).
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
messages: Endosome
messages: Expressed in embryos.

6239:CELE Y66A7A.5
gene id: 6239:CELE_Y66A7A.5
uniprot id: Q7K6J1
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F40A3.5
gene id: 6239:CELE_F40A3.5
uniprot id: O16262
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Expressed in the epidermis of larvae and adults and in vulval and rectal cells.
messages: Membrane
messages: Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE W01B11.2
gene id: 6239:CELE_W01B11.2
uniprot id: A0A8S5I9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE F29B9.10
gene id: 6239:CELE_F29B9.10
uniprot id: Q9GYI2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

6239:CELE F31D4.2
gene id: 6239:CELE_F31D4.2
uniprot id: O45417
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

6239:CELE Y43F8A.4
gene id: 6239:CELE_Y43F8A.4
uniprot id: Q9XWL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C44C10.4
gene id: 6239:CELE_C44C10.4
uniprot id: Q18616
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a modulator of condensin function, possibly by binding to the condensin SMC subunits and thereby inhibiting their function. Negatively regulates the condensin I complex in mitotic chromosome segregation. Negatively regulates the condensin I-like dosage compensation complex, which functions in the regulation of X chromosome-linked gene transcription, by limiting the association of the complex with the X chromosomes.
messages: Belongs to the SMC family.
messages: Expressed in the germline.
messages: Expressed throughout development and in adult animals.
messages: Interacts with dpy-27, mix-1, dpy-28, dpy-26, capg-1 and smc-4.
messages: Nucleus

6239:CELE B0547.1
gene id: 6239:CELE_B0547.1
uniprot id: P91001
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-1 (PubMed:12781129). Interacts with glh-1 and glh-3 (PubMed:12435362). Interacts with lag-1 (PubMed:10615043). Interacts with kgb-1 (PubMed:17699606).
messages: Cytoplasm
messages: Nucleus
messages: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity). The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3. May stabilize glh-1 protein levels by antagonizing kgb-1 (PubMed:17699606).
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

6239:CELE C44H4.2
gene id: 6239:CELE_C44H4.2
uniprot id: Q93373
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Expression begins around the ventral closure stage of embryogenesis, continues throughout larval development and decreases in adulthood.
messages: Highly lethal at L1 larval stage due to excretory defects. A small percentage of mutants die as embryos and a very small number survive to adulthood and are fertile but have defects in locomotion and egg-laying. There is no maternal effect on lethality.
messages: In L1 larvae, expressed in a subset of epithelial cells including epidermal, vulval and rectal cells and the excretory duct and pore. Absent from internal epithelia such as the gut and pharyngeal tubes. Transiently expressed in the excretory canal cell at the 1.5-fold embryonic stage but no longer visible in this cell at hatching.
messages: Required for apical extracellular matrix organization and epithelial junction maintenance.

6239:CELE C35C5.5
gene id: 6239:CELE_C35C5.5
uniprot id: Q93329
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE C52B9.9
gene id: 6239:CELE_C52B9.9
uniprot id: O45873
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE Y73F8A.25
gene id: 6239:CELE_Y73F8A.25
uniprot id: A0A078BS59
uniprot id: A0A078BTL9
uniprot id: Q9NA34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE F15G9.4
gene id: 6239:CELE_F15G9.4
uniprot id: A4UVK0
uniprot id: G5ED27
uniprot id: G5EG33
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F55C10.1
gene id: 6239:CELE_F55C10.1
uniprot id: G5EDN6
uniprot id: H9G2Y1
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the calcineurin regulatory subunit family.
messages: Cytoplasm
messages: Expressed in sperm, spermatids, spermatheca, male gonads, intestine, nerve cord, hypodermal seam cells, cuticle and excretory canal.
messages: Forms a complex composed of a calmodulin-dependent catalytic subunit tax-6 (also known as calcineurin A) and a regulatory Ca(2+)-binding subunit cnb-1 (also known as calcineurin B) which confers calcium sensitivity.
messages: Mutants grow slowly and show uncoordinated or lethargic movements (PubMed:12221132, PubMed:12684004). Increased lifespan (PubMed:19279398). Body is small and slender with a transparent appearance resulting from a thinner cuticle (PubMed:12221132, PubMed:12684004). Reduced number of progeny associated with a retention of late stage embryos in the uterus, a reduced sperm count which appears smaller and smoother and with smaller pseudopods (PubMed:12221132, PubMed:12684004). In addition, serotonin-induced egg laying is delayed (PubMed:12221132, PubMed:12684004). Increased susceptibility to nicotine-mediated paralysis (PubMed:15990870). Impaired CO2 avoidance (PubMed:18524955). Increased number of puncta positive for autophagy marker LGG-1 (PubMed:19279398). Impaired coelomocyte endocytosis, intestinal apical endocytosis and recycling of synaptic vesicles at synapses (PubMed:20803083, PubMed:21345307).
messages: Regulatory subunit of tax-6/calcineurin A, a calcium-dependent, calmodulin-stimulated protein phosphatase (PubMed:12221132). Confers calcium sensitivity (PubMed:12221132). Plays a role in egg-laying, fertility, growth, movement and cuticle development (PubMed:12221132, PubMed:12684004). Plays a role in sensitivity to CO2 levels (PubMed:18524955). Regulates expression of tax-6 inhibitor rcn-1 (PubMed:12684004). Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine (PubMed:15990870). Negatively regulates lifespan (PubMed:19279398). Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle recycling (PubMed:20803083, PubMed:21345307). May negatively regulate autophagy (PubMed:19279398).

6239:CELE R10H1.4
gene id: 6239:CELE_R10H1.4
uniprot id: Q8MPZ7
names: Subcellular Location Annotation
messages: Secreted

6239:CELE K07A3.1
gene id: 6239:CELE_K07A3.1
uniprot id: G5EBJ7
names: Similarity
messages: Belongs to the FBPase class 1 family.

6239:CELE K02B12.4
gene id: 6239:CELE_K02B12.4
uniprot id: Q3LRZ3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subunit
messages: Interacts with bar-1, dsh-2, gsk-3, and mig-5.
messages: Reporter transgenes fail to show detectable expression indicating that axl-1 may be expressed at low levels.
messages: Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development.
messages: Worms exhibit defects in excretory cell development and axonal migration.

6239:CELE B0304.3
gene id: 6239:CELE_B0304.3
uniprot id: Q27465
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C35A5.6
gene id: 6239:CELE_C35A5.6
uniprot id: Q18474
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F47D12.5
gene id: 6239:CELE_F47D12.5
uniprot id: Q09562
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F55C10.5
gene id: 6239:CELE_F55C10.5
uniprot id: Q7YX00
names: Similarity
messages: Belongs to the PP1 inhibitor family.

6239:CELE H02I12.8
gene id: 6239:CELE_H02I12.8
uniprot id: G5EGT6
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE EGAP7.1
gene id: 6239:CELE_EGAP7.1
uniprot id: Q19079
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K08E3.7
gene id: 6239:CELE_K08E3.7
uniprot id: Q9XUS3
uniprot id: V6CLF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBR family. Parkin subfamily.
messages: Forms an E3 ubiquitin ligase complex.
messages: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
messages: Mitochondrion
messages: cytosol

6239:CELE C10H11.7
gene id: 6239:CELE_C10H11.7
uniprot id: P91035
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F11A10.4
gene id: 6239:CELE_F11A10.4
uniprot id: Q19338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON2 family.
messages: Golgi apparatus
messages: May be required for traffic between late Golgi and early endosomes.

6239:CELE T23H4.2
gene id: 6239:CELE_T23H4.2
uniprot id: P91829
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in 8 dpc intestinal precursor cells in developing embryos, and in intestine throughout development into adulthood.
messages: Expressed in the ASI neurons, hypodermis, and in tail neurons.
messages: Interacts with R-SMAD daf-8.
messages: Nucleus
messages: On a temperature-sensitive daf-7 mutant background, enhances entry of larvae into the developmentally arrested state known as dauer, and also suppresses exit from dauer (PubMed:22359515). Up-regulates expression of the potassium channel exp-2 (PubMed:22359515).
messages: Orphan nuclear receptor which, in cooperation with R-SMAD daf-8, modulates the Insulin/IGF-1-like signaling (IIS) pathway, perhaps by regulating expression of the potassium channel exp-2, which in turn modulates the secretion of insulin-like peptide daf-28.

6239:CELE T24D11.1
gene id: 6239:CELE_T24D11.1
uniprot id: S6F527
names: Function
names: Subunit
names: Tissue Specificity
messages: Highly expressed in the terminal bulb muscles, pharyngeal muscle, in intestine and vulva.
messages: May interact with rab-6.2 (in GTP-bound form).
messages: Rab GTPase activating protein for the small GTPase rab-6.2 (PubMed:23792950). Required for grinder formation, which is the feeding organ that breaks down food (PubMed:23792950).

6239:CELE H19M22.3
gene id: 6239:CELE_H19M22.3
uniprot id: O44836
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M10A family.
messages: Expressed at the comma, 1.5-fold and 3-fold embryonic stages in multiple cells including muscle and somatic gonad cells. In L1 larvae, predominantly expressed in specific muscles and somatic gonad cells, in L2 larvae predominantly expressed in muscles cells and in L4 larvae expressed predominantly in the developing spermatheca and more weakly in vulva muscle cells. Expression increases in the hypodermis in dauer stage larvae prior molting to L4 larval stage.
messages: Expressed in spermatheca and spermathecal-uterine valve, weakly in vulva and anal muscles and in two cells in the head (probably RMEV and RMED motor neurons).
messages: Inhibited by human TIMP1 and TIMP2 and the broad MMP inhibitors BB94 (Batimastat) and CT543.
messages: Intron retention.
messages: Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:24957743). Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol (PubMed:20600277, PubMed:24957743).
messages: RNAi-mediated knockdown causes a delay in larval to adult development with reduced motility and feeding (PubMed:20600277). Also reduces fecundity in adults (PubMed:20600277). Larvae have molting defects characterized by incomplete cuticle shedding leaving a constriction ring in the larvae anterior part (PubMed:20600277). Reduces survival upon Gram-negative bacterium P.luminescense infection or heat stress (PubMed:20600277, PubMed:24957743). Production of extra- and intra-cellular reactive oxygen species (ROS) and protein oxidation are increased whereas vit-6 transcription and dehydroergosterol (DHE) uptake are reduced (PubMed:24957743). Moreover, causes constitutive daf-16 nuclear localization (PubMed:24957743). Simultaneous RNAi-mediated knockdown of vit-6, rme-2, daf-16 or daf-16 coactivators sir2.1, ftt-2 and par-2 restores normal thermotolerance (PubMed:24957743). RNAi-mediated knockdown in a daf-9 or daf-12 mutant background reduces survival further upon heat stress.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

6239:CELE F07G11.4
gene id: 6239:CELE_F07G11.4
uniprot id: O16230
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE T23D8.1
gene id: 6239:CELE_T23D8.1
uniprot id: A0A0K3AWM6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Early endosome
messages: Embryonic lethal with severely defective embryonic morphogenesis (PubMed:9288749, PubMed:9288750, PubMed:15620652). Embryos have defective mitotic spindle orientation in the 8-cell stage ABar blastomere (PubMed:9288749, PubMed:9288750, PubMed:20126385). Furthermore, there is disrupted asymmetric distribution of the transcription factor pop-1 and the disheveled homolog dsh-2, which are required for cell fate decisions in 8-cell stage ABar blastomeres and their descendants (PubMed:12810601, PubMed:15990090). There is also abnormal distal tip cell migration along the anterior-posterior axis of the body and defective clearance of apoptotic cell corpses in embryos (PubMed:20126385, PubMed:26292279). Both double knockout with unc-5 RNAi and knockdown by RNAi in an unc-40 mutant background suppresses the migratory defect of distal tip cells in the mom-5 and unc-40 single mutants (PubMed:26292279). Double knockout with Wnt receptor cfz-2 results in enhanced CAN neuron migration defects and also rescues the ALM migration defects in the single cfz-2 knockout (PubMed:16109397). Double knockout with Wnt receptor mig-1 results in enhanced HSN neuron migration defects and also in anterior-posterior axon guidance defects of PVM and AVM touch neurons (PubMed:16516839). RNAi-mediated knockdown results in embryonic lethality, but surviving animals display morphogenesis defects and PHA phasmid neuron duplication (PubMed:15990090).
messages: Expressed in the 32-cell stage ABar blastomere and onwards into late embryogenesis (PubMed:15620652, PubMed:24401370). In late embryogenesis, enriched at the leading edges of postmitotic epidermal cells during ventral enclosure (PubMed:15620652). Asymmetrically expressed during the larval stages of development in cells of the gonad, vulva, tail, nervous system and hypodermis (PubMed:15620652). Expressed predominantly in QR neuroblast descendants and to a lesser extent in QL neuroblast descendants during the larval stages of development (PubMed:25373777). Expressed highly in anterior P-cells during larval development (PubMed:23295860). Post-embryonically, it is up-regulated at the transition phase after dorsal-ventral migration of distal tip cells and at the beginning of their anterior-posterior migration (PubMed:26292279).
messages: Receptor for Wnt proteins (PubMed:16930586, PubMed:22022276, PubMed:23295860, PubMed:24401370, PubMed:26292279). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). Both pathways seem to involve interactions with G-proteins (Probable). Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:9288749, PubMed:9288750, PubMed:20126385). During early embryonic cell divisions, directs the asymmetric positioning of transcription factors such as pop-1 and dsh-2 in daughter cells in order to determine cell fate specification (PubMed:12810601, PubMed:15620652, PubMed:15990090). Acts redundantly with other Wnt receptors such as lin-17 to control vulval precursor cell specification and also the polarity of different cell types including distal tip cells, seam cells, AVG interneurons and P-cells and their descendants (PubMed:16930586, PubMed:20126385, PubMed:22022276, PubMed:23295860, PubMed:24401370, PubMed:26292279). Plays a role in the migration of cell types including distal tip cells and the QR neuroblast descendants, QR.p and QR.pa during larval development (PubMed:20126385, PubMed:25373777, PubMed:26292279). Negatively regulates the unc-6/Netrin receptors unc-5 and unc-40 to control distal tip cell polarity and migration (PubMed:26292279). Acts through ced-5/DOCK180 and ced-10/Rac to control both distal tip cell migration and the phagocytic clearance of apoptotic cell corpses (PubMed:20126385…
messages: The FZ domain is involved in binding with Wnt ligands.

6239:CELE F25B4.6
gene id: 6239:CELE_F25B4.6
uniprot id: P54871
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: RNAi-mediated knockdown results in sterility, slow development, reduced body size, severe paralysis and reduced pharyngeal pumping.
messages: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
messages: Ubiquitinated.

6239:CELE Y65B4A.2
gene id: 6239:CELE_Y65B4A.2
uniprot id: Q9BL59
uniprot id: V6CLS8
uniprot id: V6CLX0
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F25H2.1
gene id: 6239:CELE_F25H2.1
uniprot id: Q93565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

6239:CELE T19A5.4
gene id: 6239:CELE_T19A5.4
uniprot id: Q22555
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T06E4.4
gene id: 6239:CELE_T06E4.4
uniprot id: Q22256
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F55G1.11
gene id: 6239:CELE_F55G1.11
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C02C2.1
gene id: 6239:CELE_C02C2.1
uniprot id: P34269
names: Cofactor
names: Similarity
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.

6239:CELE R12B2.4
gene id: 6239:CELE_R12B2.4
uniprot id: Q21952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity (PubMed:11402066, PubMed:14522947, PubMed:15371539). The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which is composed of at least ndc-80 and him-10. The NDC80 complex interacts with knl-1.
messages: Nucleus
messages: kinetochore

6239:CELE ZK75.1
gene id: 6239:CELE_ZK75.1
uniprot id: Q09626
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed by ASI and ASJ sensory neurons and weakly by ventral cord motor neurons.
messages: Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions (PubMed:23665919). Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions (PubMed:24671950).
messages: Secreted

6239:CELE M88.6
gene id: 6239:CELE_M88.6
uniprot id: Q9U3A0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Cytoplasm
messages: Expressed at all developmental stages from embryos undergoing morphogenesis to gravid adults (PubMed:23682709). Broadly expressed in embryos and early larvae, but expression decreases in late larvae and adults (PubMed:33950834). Expressed in seam cells during larval development (PubMed:33950834). Expressed in DD GABAergic motor neurons in L1 and L2 stage larva (PubMed:33950834). During larval stage L1, expressed in the pharynx and in intestinal cells (PubMed:22342905). Expressed most strongly during mid-to-late intermolt periods (at protein level) (PubMed:23682709).
messages: Expressed in germline cells (PubMed:22342905).
messages: Expressed in the germline and somatic cells (PubMed:22342905).
messages: Expressed in the germline and somatic cells (PubMed:22342905). Expressed at higher levels in germline cells relative to somatic cells (PubMed:22342905).
messages: Highly expressed in the pharynx and at lower levels in the intestine, but not detected in other tissues (PubMed:22342905). Other studies suggest a broader expression pattern in somatic tissues: from embryogenesis to adult stages, expressed strongly in body wall muscle, vulva, somatic gonad and pharynx, at lower levels in the nerve ring, hypodermis, and rectal epithelia, and very weakly in the intestine (PubMed:23682709).
messages: Interacts with glh-1 (PubMed:22342905). Interacts (via LRR regions) with myrf-1 (via C-terminus); the interaction promotes the role of myrf-1 in the synaptic remodeling of DD GABAergic motor neurons at the cell membrane (PubMed:33950834).
messages: Larval lethal. Animals developmentally arrest prior to the first larval molt and subsequent growth is slow, although larvae survive for up to 8 days at 20 degrees Celsius. Animals also display uncoordinated locomotion, a shortened cuticle, pharyngeal defects, stunted gonad development, and abnormal vulval morphogenesis. Heterozygous worms have reduced brood sizes. Knockout in DD GABAergic motor neurons results in defective synaptic remodeling of DD GABAergic motor neurons (PubMed:33950834). RNAi-mediated knockdown in the germline, results in sterility and gametogenesis phenotypes including complete absence of oocytes, endomitotically replicating oocytes, and failure to lay eggs. Animals surviving to the L4 stage have hypodermal defects including lack of lateral alae and incomplete seam cell fusion, and fail to express col-19 and mlt-10. RNAi-mediated knockdown in lin-29 null mutants results in partial suppression of the molting and vulval RNAi phenotypes in L4 stage larvae.
messages: Promotes the localization of myrf-1 and myrf-2 to the cell membrane (PubMed:33950834). In association with myrf-1, promotes the synaptic remodeling of DD GABAergic motor neurons whereby new synapses form in the dorsal processes of DD neurons (PubMed:33950834).
messages: Regulates diverse developmental processes including larval molting and gonad maturation.

6239:CELE F41C3.4
gene id: 6239:CELE_F41C3.4
uniprot id: Q20263
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Expressed widely during larval and adult stages.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex (By similarity). Involved in regulating AMsh glial cell size, acting by modulating the E3 ubiquitin ligase rnf-145/RNF145, probably by mediating the translocation of rnf-145 from the cis-Golgi to the trans-Golgi during development (PubMed:33370778).
messages: RNAi-mediated knockdown causes embryonic lethality, but about 10% of animals survive to early adulthood (PubMed:33370778). Significantly enlarged AMsh glial cells (PubMed:33370778).
messages: cis-Golgi network

6239:CELE C07B5.5
gene id: 6239:CELE_C07B5.5
uniprot id: Q17778
names: Function
names: Similarity
messages: Belongs to the DNase II family.
messages: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis.

6239:CELE F35G12.10
gene id: 6239:CELE_F35G12.10
uniprot id: Q20053
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the subunits of the catalytic subcomplexes relative to the rotary elements (Probable). Plays a role in germline development (PubMed:17223323).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown results in sterility (PubMed:17223323). RNAi-mediated knockdown does not affect the timing of hypodermal and vulval development (PubMed:17223323).
messages: Specifically expressed in the germline from the L1 larval stage.
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE K01A12.3
gene id: 6239:CELE_K01A12.3
uniprot id: Q10042
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

6239:CELE R107.7
gene id: 6239:CELE_R107.7
uniprot id: P10299
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Pi family.
messages: By manganese.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876).
messages: Expressed in dopaminergic (DA) neuron (at protein levels).
messages: Homodimer.
messages: RNAi-mediated knockdown causes an increase in Mn(2+)-mediated dopaminergic CEP neuron degeneration.

6239:CELE F42A10.3
gene id: 6239:CELE_F42A10.3
uniprot id: Q20308
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

6239:CELE ZK675.1
gene id: 6239:CELE_ZK675.1
uniprot id: Q09614
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the patched family.
messages: Expressed both maternally and zygotically.
messages: Germ line and its progenitors.
messages: Membrane
messages: Membrane proteins Patch and Smoothened form a receptor complex that binds Hedgehog morphogens. Despite the lack of Hh and Smo homologs, ptc-1 is still found to be functional. Absence of ptc-1 leads to the formation of multinucleate germ cells and sterility.
messages: Required but not essential for cytokinesis of mitotically proliferating germ cells.

6239:CELE C01F6.4
gene id: 6239:CELE_C01F6.4
uniprot id: P34691
names: Developmental Stage
names: Function
names: Subunit
messages: Component of a complex containing fem-1, fem-2 and fem-3 (PubMed:23760267). Interacts with fem-1 and fem-2 (via N-terminus) (PubMed:23760267, PubMed:17609115). Part of a E3 ubiquitin-protein ligase complex, at least composed of cul-2, elc-1, tra-1, fem-1, fem-2 and fem-3; mediates the ubiquitination and subsequent proteasomal degradation of tra-1 (PubMed:17609115). Interacts with tra-1 (PubMed:17609115). Interacts with sel-10 (PubMed:15306688). Interacts with tra-2 (PubMed:10364161, PubMed:12477393).
messages: Expressed both maternally and zygotically.
messages: Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite) animals, it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. Together with fem-2 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1.

6239:CELE H14E04.5
gene id: 6239:CELE_H14E04.5
uniprot id: Q9TYP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE EGAP1.3
gene id: 6239:CELE_EGAP1.3
uniprot id: G5EGM1
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the peptidase M10A family.
messages: Cell membrane
messages: Displays very low catalytic activity compared to zmp-2 towards synthetic substrate Mca-Pro-Leu-Gly-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 in vitro.
messages: Expressed in the anchor cell (PubMed:11060231, PubMed:15960981). Expressed in the anchor cell throughout the L3 and the early L4 stage, but not in vulva precursor cells P6.p, P6.px, or P6.pxx (PubMed:11060231). Expression in P6.pxxx cells begins in late-L4 stage. During L4 lethargus, expressed in all four vulE cells, but not in vulF cells (PubMed:11060231). The expression in vulE cells persists in adulthood (PubMed:11060231). In males, expressed in the linker cell (LC) from the early L4 stage until LC death during the L4-to-adult molt (PubMed:19906858).
messages: Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium.
messages: No defect in anchor cell invasion. In 7 percent of cdh-3 and zmp-1 double mutants and in 25 percent of cdh-3, him-4 and zmp-1 triple mutants, anchor cell invasion is delayed.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

6239:CELE R09H10.5
gene id: 6239:CELE_R09H10.5
uniprot id: Q21884
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C35E7.9
gene id: 6239:CELE_C35E7.9
uniprot id: O61765
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE K12H6.6
gene id: 6239:CELE_K12H6.6
uniprot id: Q9N5G9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F09C6.9
gene id: 6239:CELE_F09C6.9
uniprot id: G5EE21
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y43C5B.2
gene id: 6239:CELE_Y43C5B.2
uniprot id: Q9XXE5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE M106.5
gene id: 6239:CELE_M106.5
uniprot id: P34686
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

6239:CELE W03A5.6
gene id: 6239:CELE_W03A5.6
uniprot id: Q23138
names: Similarity
messages: Belongs to the SAPAP family.

6239:CELE C24G6.3
gene id: 6239:CELE_C24G6.3
uniprot id: O76384
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

6239:CELE Y54F10AM.5
gene id: 6239:CELE_Y54F10AM.5
uniprot id: Q9BL03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane

6239:CELE Y48E1B.1
gene id: 6239:CELE_Y48E1B.1
uniprot id: O18195
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity). Acts as a component of the DHIC (ddl-1-containing hsf-1 inhibitory complex) which modulates lifespan by sequestering the heat shock transcription factor hsf-1 to negatively regulate its binding to DNA and its transcriptional activity (PubMed:22265419).
messages: Belongs to the WASH1 family.
messages: Component of the WASH core complex (By similarity). Component of the DHIC (ddl-1-containing hsf-1 inhibitory) complex, which contains at least ddl-1, ddl-2, hsb-1 and hsf-1 (PubMed:22265419). Within the complex, interacts with ddl-1 (PubMed:22265419). Formation of the DHIC may be dependent upon the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:22265419).
messages: Expressed in several neurons located throughout the body.
messages: RNAi-mediated knockdown positively modulates lifespan; effect abolished in hsf-1 mutant background (PubMed:22265419). Increases resistance to both heat and oxidative stresses (PubMed:22265419). Increases localization to the nucleus and also DNA binding activity of heat-shock transcription factor hsf-1 after heat shock (PubMed:22265419). Increases in transcript levels of heat shock protein genes sim-1, hsp-70, hsp-16.2 and F44E5.5 after heat shock, but not in unstressed conditions (PubMed:22265419). May also moderately decrease levels of post-translationally modified hsf-1 under heat stressed conditions (PubMed:22265419).

6239:CELE ZK858.1
gene id: 6239:CELE_ZK858.1
uniprot id: G5EFL0
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumulation in the hermaphrodite germline. In the germline, forms a complex with gls-1 which directly binds to gld-1 mRNA and prevents its degradation.
messages: Expressed both maternally and zygotically throughout embryonic development and in adult hermaphrodites.
messages: Germline-specific.
messages: High embryonic lethality. Hermaphrodite animals are partially fertile and those that produce sperm and oocytes have reduced brood sizes and display smaller germlines. Hermaphrodite gld-4 and gld-2 double mutants are fully sterile and display either an earlier meiotic arrest than gld-2 single mutant or a failure to commit to meiotic progression and a return to mitosis.
messages: In contrast to other poly(A) RNA polymerases, lacks any RNA-binding domain.
messages: Interacts with gls-1 isoform C.
messages: The gld-4 locus produces a single transcript that is SL-1 trans-spliced.
messages: perinuclear region

6239:CELE B0546.2
gene id: 6239:CELE_B0546.2
uniprot id: O44438
names: Similarity
messages: Belongs to the peptidase C85 family.

6239:CELE F57B1.2
gene id: 6239:CELE_F57B1.2
uniprot id: Q20924
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos (PubMed:24297748).
messages: Nucleus envelope
messages: Nucleus membrane
messages: RNAi-mediated knockdown disrupts both the localization of pot-1 and the anchoring of telomeres to the nuclear envelope in early embryos.
messages: The SUN domain may play a role in nuclear anchoring.

6239:CELE F09E5.1
gene id: 6239:CELE_F09E5.1
uniprot id: Q19266
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abundantly expressed in the anterior and posterior pharyngeal bulbs, the pharyngeal-intestinal valve, vulval cells, and a region at the posterior end of the intestine that corresponds to site of co-assembly of the intestinal-rectal valve and anal sphincter, and depressor muscles. Modest expression apparent in four hypodermal cells that provide cuticle and muscle anchorage in the tail. Strong expression observed in discrete patches and spots in vulval cells and in somatic cells of the spermatheca. Transiently coexpressed and colocalized with par-6 and par-3, asymmetrically in the developing somatic gonad, including the spermathecal precursor cells of L4 larvae.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Expressed throughout development, at highest level in the L1 stage and lowest in L3. Peripheral staining pattern in early embryos. The staining in 1-cell embryos is weak and uniform just after the completion of meiosis, but increases in intensity and becomes concentrated at the anterior periphery during pronuclear migration. The peripheral staining becomes restricted to about 50% embryo length during the pronuclear meeting and pronuclear fusion stage. By early anaphase, the staining extends posteriorly beyond the midline of the zygote and covers about 60% of the total length of embryos. In 2- and 4-cell stages, staining is uniform at the periphery of the AB cell, its daughters and the EMS cell, but peripheral staining in P1 and P2 is restricted to the boundaries with other blastomeres.
messages: Interaction with par-3 required for the peripheral localization of par-6 and to form a par-3/par-6/pkc-3 complex, which is activated when cdc-42 interacts with par-6. Binds avidly to the phosphotyrosine interaction domain (PID) of a novel pkc-3 adapter protein num-1, which enables tethering and targeting of pkc-3 to the cell periphery.
messages: Required for the normal progression of embryogenesis and viability of the organism (PubMed:9422779). Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3 (PubMed:9716526, PubMed:9834192). Required for epithelial cell polarity in the distal spermatheca (PubMed:15151982). Phosphorylates serine residues of num-1 (PubMed:11134025). Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury (PubMed:19380113).
messages: Residues 212-224 are capable of binding the PID domain of num-1 isoform a and isoform c.
messages: Worms show defects in embryogenesis. Mutant embryos show defects in their polarity and cleavage patterns which disrupt hatching (PubMed:9716526). RNAi-mediated knockdown causes a complete loss of nlp-29 expression following fungal infection by D.coniospora or physical injury (PubMed:19380113).
messages: cytoskeleton

6239:CELE K12G11.3
gene id: 6239:CELE_K12G11.3
uniprot id: Q17334
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Homotetramer.

6239:CELE C06E1.3
gene id: 6239:CELE_C06E1.3
uniprot id: P34298
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DUOXA family.
messages: Expressed in the hypodermis, specifically in seam cells, the terminal bulb of the pharynx, the distal region of the gonadal arm, vulva, spermatheca and uterus.
messages: Interacts with bli-3 and tsp-15.
messages: Membrane
messages: Plays a role in cuticle biogenesis (PubMed:23028364, PubMed:25480962). In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix (PubMed:23028364).
messages: RNAi-mediated knockdown results in a blistered cuticle phenotype and resistance to iodide toxicity.

6239:CELE F28B3.4
gene id: 6239:CELE_F28B3.4
uniprot id: A0A061AD00
uniprot id: A0A061AE78
names: Similarity
messages: Belongs to the DIP2 family.

6239:CELE C17E7.1
gene id: 6239:CELE_C17E7.1
uniprot id: O16398
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C25A1.10
gene id: 6239:CELE_C25A1.10
uniprot id: Q9XVS4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NOLC1 family.
messages: Expressed in the nerve ring and hypodermal tissues (PubMed:24722283). Expressed in the intestine (PubMed:20405020, PubMed:24722283). Expressed in the germline (PubMed:20405020).
messages: Expressed throughout embryonic development and in adults (PubMed:22768349). During embryogenesis, expressed from the 2-cell stage and persists throughout development in transcriptionally active cells (PubMed:22768349). Expression is higher in dauer larvae than in adults (PubMed:11743719).
messages: May form dimers (PubMed:20405020). Interacts with RNA polymerase I (PubMed:24722283).
messages: Nucleolar protein which binds to RNA polymerase I and rDNA and is required for efficient RNA polymerase I-mediated rDNA transcription (PubMed:24722283). Maintains the epigenetically active status of rDNA chromatin which facilitates rDNA transcription and sustains germline development, ensuring fertility (PubMed:24722283). Plays a role in the modulation of nucleolus size (PubMed:27003693). May play a role in the regulation of lifespan (PubMed:11743719).
messages: nucleolus
messages: nucleoplasm

6239:CELE C10G8.6
gene id: 6239:CELE_C10G8.6
uniprot id: Q94165
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcription regulator (PubMed:20713707). Binds to the sequence motif 5'-TCAGGTT-3' (PubMed:20335356). Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis (PubMed:20713707). Also promotes apoptosis of I1 pharyngeal neuron sister cell (PubMed:20713707). Together with eya-1, required to specify the coelomocyte fate in embryonic and postembryonic precursors (PubMed:19427847, PubMed:20335356).
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Expression starts at the embryonic bean stage and continues throughout larval and adult stages in few anterior body wall muscle cells and in unidentified cells in the head (PubMed:19427847). Expressed predominantly in pharyngeal cells during embryogenesis and throughout larval and adult stages (PubMed:20713707). In L1 larvae, expressed in all pharyngeal neurons (M4, I1, MI, I3, M3, NSM, MC, I2, I4, I5, I6, M1, M2, and M5), some pharyngeal muscle cells (pm1 and pm2) and pharyngeal epithelial cells (e1 and e3), and some body wall muscles around the anterior pharynx (PubMed:20713707). Expressed transiently in the M lineage-derived coelomocyte precursor cells M.dlpa and M.drpa before their differentiation into coelomocytes (PubMed:19427847, PubMed:20335356). Expressed in the M4 motor neuron sister cell (PubMed:20713707).
messages: Interacts (via N-terminus) with eya-1 (via C-terminus).
messages: Nucleus
messages: RNAi-mediated knockdown in embryos causes lethal arrest at the embryonic 3-fold stage or at the L1 larval stage with abnormal anterior morphology (PubMed:19427847). The few surviving animals lack 1 or both pairs of embryonic MS lineage-derived coelomocytes as well as the 2 post embryonic M lineage-derived coelomocytes (PubMed:19427847). RNAi-mediated knockdown in L1 larvae causes the loss of the M lineage-derived coelomocytes due to the abnormal differentiation of coelomocyte precursors M.drpa and M.dlpa into body wall muscle cells (PubMed:19427847). In 38 percent of animals, the motor neuron M4 sister survived (PubMed:20713707).

6239:CELE ZK370.8
gene id: 6239:CELE_ZK370.8
uniprot id: Q02335
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Tom70 family.
messages: Expressed in body wall muscle cells, the pharynx and structures in the tail.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
messages: Mitochondrion outer membrane
messages: Receptor that accelerates the import of all mitochondrial precursor proteins.

6239:CELE F22B7.7
gene id: 6239:CELE_F22B7.7
uniprot id: P34410
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C38C10.5
gene id: 6239:CELE_C38C10.5
uniprot id: Q03570
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for transcription in the embryo and for phosphorylation of the RNA polymerase II C-terminal domain repeat.
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE ZK512.4
gene id: 6239:CELE_ZK512.4
uniprot id: P34642
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).
messages: Cytoplasm
messages: Heterodimer with SRP14; binds RNA as heterodimer (By similarity). Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9 (By similarity).

6239:CELE F14F8.5
gene id: 6239:CELE_F14F8.5
uniprot id: Q9XU36
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C14F5.1
gene id: 6239:CELE_C14F5.1
uniprot id: Q09969
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NIP3 family.
messages: Expressed in all somatic tissues including neurons, pharynx, intestine, body wall muscles and vulva muscles.
messages: Expressed in the embryo and throughout all stages of development to adulthood.
messages: Homodimer; via transmembrane domain (PubMed:11114722, PubMed:9824163). Interacts with ced-3 and ced-9 (PubMed:9824163).
messages: Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes (PubMed:11114722). Has a role in lifespan and tumor growth (PubMed:16380712, PubMed:17934462). Required for the induction of mitophagy under stress conditions (PubMed:25896323).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown causes an increased sensitivity to stress and inhibits mitophagy which leads to an accumulation of defective mitochondria that have increased mass, altered network morphology, decreased ATP levels, increased reactive oxygen species (ROS) generation, membrane depolarization, increased oxygen consumption and increased cytoplasmic Ca(2+) that intensifies under stress conditions. RNAi-mediated knockdown in daf-2, isp-1, or clk-1 mutant backgrounds suppresses their increased lifespan phenotype.
messages: Ubiquitinated and degraded by the proteasome (PubMed:11114722). Under oxidative stress conditions, ubiquitinated at Lys-26 in a pink-1 dependent manner. Colocalizes with pdr-1 and may be ubiquitinated by it (PubMed:25896323).

6239:CELE Y44F5A.1
gene id: 6239:CELE_Y44F5A.1
uniprot id: G5EEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

6239:CELE B0395.2
gene id: 6239:CELE_B0395.2
uniprot id: Q17498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R160.1
gene id: 6239:CELE_R160.1
uniprot id: P35603
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit and beta-type subunits), a medium adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit AP17).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Brain, heart, lung, liver, testis and spleen.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells (PubMed:18160346, PubMed:18160347). Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells (PubMed:18160346, PubMed:18160347). During development, regulates the migration of HSN neurons and the left and right Q neuroblasts (QL and QR, respectively) and their descendants, possibly through hox gene and wnt/egl-20 gene target mab-5, and plays a role in establishing ALM and PLM neuronal cell polarity (PubMed:18160346). Required for the asymmetric divisions of V5 cells (PubMed:18160346).
messages: Mutants display a squat body statue referred to as a dumpy phenotype and have defective HSN neuronal cell migration (PubMed:18160346). RNAi-mediated knockdown results in impaired function of the AP-2 complex and accumulation of the wntless homolog mig-14 at the cell membrane (PubMed:18160347).
messages: coated pit

6239:CELE K03A11.1
gene id: 6239:CELE_K03A11.1
uniprot id: G5EDX0
names: Similarity
messages: Belongs to the E2F/DP family.

6239:CELE T07C5.2
gene id: 6239:CELE_T07C5.2
uniprot id: Q22298
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F07A11.6
gene id: 6239:CELE_F07A11.6
uniprot id: G5EGK6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Isoform d interacts with daf-12.
messages: Isoform d is widely expressed: detected in the hypodermis, seam cells, intestine, somatic gonad, neurons, vulval precursors, body wall muscle and pharynx.
messages: Isoforms b and d are widely expressed from embryogenesis to adulthood. Isoform d is highly expressed in late L1 and L2 larval stages in XXX neuroendocrine cells. Isoform b is expressed more highly in the embryo and the L1 larval stage.
messages: Knockout of isoform d results in defective dauer formation. Eighteen percent of temperature sensitive mutants are embryonic lethal. The surviving animals are small (Sma), clear (Clr), uncoordinated, constipated and sterile. They display variable morphological defects in the main body and pharynx.
messages: Nucleus
messages: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause.

6239:CELE F11C3.2
gene id: 6239:CELE_F11C3.2
uniprot id: G5EGP1
names: Caution
names: Similarity
messages: Belongs to the cuticular collagen family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F38H4.6
gene id: 6239:CELE_F38H4.6
uniprot id: Q20185
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T06C12.7
gene id: 6239:CELE_T06C12.7
uniprot id: O45756
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C08B11.7
gene id: 6239:CELE_C08B11.7
uniprot id: Q09444
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase C12 family.
messages: Expression decreases with age.
messages: Highly expressed in intestine and to a lesser extent in other tissues including muscles and neurons.
messages: Interacts with proteasome 19S subunit rpn-13.
messages: RNAi-mediated knockdown causes a slight decrease in lifespan and in brood size. Enhanced proteasome activity, specifically in the intestine.
messages: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.

6239:CELE ZK863.3
gene id: 6239:CELE_ZK863.3
uniprot id: Q23651
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).
messages: Component of the elongator complex.
messages: The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.

6239:CELE C54C8.7
gene id: 6239:CELE_C54C8.7
uniprot id: O17705
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y46H3D.5
gene id: 6239:CELE_Y46H3D.5
uniprot id: H2KZT0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F27D9.7
gene id: 6239:CELE_F27D9.7
uniprot id: Q19844
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K01C8.1
gene id: 6239:CELE_K01C8.1
uniprot id: Q21080
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

6239:CELE C47A4.3
gene id: 6239:CELE_C47A4.3
uniprot id: Q9U3L7
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE T03G11.4
gene id: 6239:CELE_T03G11.4
uniprot id: Q22120
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

6239:CELE F09G2.3
gene id: 6239:CELE_F09G2.3
uniprot id: O17404
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

6239:CELE C27H5.5
gene id: 6239:CELE_C27H5.5
uniprot id: P34803
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE K03E6.4
gene id: 6239:CELE_K03E6.4
uniprot id: Q21191
names: Subcellular Location Annotation
messages: cilium basal body

6239:CELE M79.1
gene id: 6239:CELE_M79.1
uniprot id: P03949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Functions downstream of migratory protein mig-13 and is involved in Q neuroblast migration during larval development (PubMed:27780040). Recruited by mig-13 to the leading edge of Q neuroblasts and their descendents to signal downstream, likely to the wve-1 pathway, and direct migration along the anteroposterior body axis (PubMed:27780040). Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024).
messages: Interacts (via SH2 and SH3 domains) with mig-13; the interaction is direct. May interact with soem-1.

6239:CELE ZC155.5
gene id: 6239:CELE_ZC155.5
uniprot id: H2KZ72
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expression detected in motor neurons.
messages: Interacts with vps-51 and vps-52.
messages: trans-Golgi network

6239:CELE F21D5.1
gene id: 6239:CELE_F21D5.1
uniprot id: Q19680
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

6239:CELE K01H12.2
gene id: 6239:CELE_K01H12.2
uniprot id: G5EFW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE Y71F9AL.18
gene id: 6239:CELE_Y71F9AL.18
uniprot id: A0A0K3ARD5
uniprot id: Q9N4H4
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Inhibited by N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide HCl (PJ34), 1,5-dihydroxyisoquinoline (DHQ) and 3-aminobenzamide (3AB).
messages: Nucleus
messages: Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death (PubMed:15923155). Involved in protection of the genome against mutations (PubMed:12600937).
messages: Predominantly expressed at early embryonic stages and later in L4 and adult stages.

6239:CELE W02D3.2
gene id: 6239:CELE_W02D3.2
uniprot id: O01815
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Mitochondrion inner membrane

6239:CELE K02B9.2
gene id: 6239:CELE_K02B9.2
uniprot id: Q21127
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: Expressed in the P lineage during embryogenesis (PubMed:18202375). Expressed at the 4- to 8-cell stage, and expression remains throughout the remaining P cell divisions in P2, P3 and P4 cells, and subsequently in primordial germ cells Z2 and Z3 (PubMed:18202375).
messages: P granule component, which acts redundantly with P granule component meg-1 to promote P granule segregation during embryogenesis, and germ cell proliferation and differentiation in larval stages (PubMed:18202375, PubMed:21305687, PubMed:25535836). Together with phosphorylated meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). Together with dephosphorylated meg-1, promotes the assembly and accumulation of zygotic P granules in the posterior cytoplasm of pre-gastrulation embryos (PubMed:25535836). Required for fertility (PubMed:18202375, PubMed:21305687).
messages: RNAi-mediated knockdown results in sterility, and in P granule segregation defects (PubMed:18202375). RNAi-mediated knockdown increases the sterility phenotype of meg-1 vr10 and meg-1 vr11 mutants from 15 to 100% and from 4 to 93%, respectively, and results in a larger proportion of under-proliferated gonads than in the single meg-1 mutants (PubMed:18202375, PubMed:21305687, PubMed:25535836). Simultaneous RNAi-mediated knockdown of meg-1 and meg-2 results in defects in P granule disassembly in the anterior cytoplasm of the P1 blastomere causing some P granules to be mis-segregated to somatic blastomeres (PubMed:25535836).

6239:CELE T12A7.2
gene id: 6239:CELE_T12A7.2
uniprot id: A0FLR6
uniprot id: L8E6K9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y62E10A.10
gene id: 6239:CELE_Y62E10A.10
uniprot id: Q9U1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Membrane

6239:CELE Y59H11AM.1
gene id: 6239:CELE_Y59H11AM.1
uniprot id: Q95XU7
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T23H2.5
gene id: 6239:CELE_T23H2.5
uniprot id: Q94148
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Almost ubiquitously expressed. Expressed in intestine, hypodermis, seam cells, body-wall muscles, many neurons, oviduct sheath cell, spermatheca, coelomocytes and pharyngeal and nerve ring.
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts (GTP-bound form) with ehbp-1 (via C-terminal coiled coil) (PubMed:20573983, PubMed:22869721). Interacts (GTP-bound form) with cnt-1 (via C-terminal ankyrin repeat) (PubMed:22869721). Interacts (GTP-bound form) with rab-5 GAP, tbc-2 (via putative coiled coil domain) (PubMed:23100538, PubMed:26393361). Interacts (GTP-bound form) with amph-1 (PubMed:26393361).
messages: Intestinal cells exhibit abnormally abundant rab-5 and rab-7 positive enlarged early endosomes, which accumulate basolaterally recycling transmembrane cargo molecules and fluid indicating a block in basolateral transport (PubMed:16394106, PubMed:20573983). On the other hand, rme-1 positive recycling endosomes are missing. No endocytic trafficking defects in oocytes or coelomocytes (PubMed:16394106). Almost complete loss of cnt-1 endosomal localization in the intestinal epithelium. Overaccumulation of endosomal phosphatidylinositol-4,5-bisphosphate (PubMed:22869721). Nearly complete loss of basolateral endosomal tubule extensions of the intestine (PubMed:25301900). The endosomal localization of tbc-2 is strongly reduced leading to increased rab-5 association with membranes in the intestinal epithelia (PubMed:26393361). Cholesterol-dependent accumulation of glr-1 in large accretions running along the length of the ventral cord neurite bundle while synapses don't have general formation defects. Animals display a decreased frequency of locomotional reversals and significantly reduced response to nose-touch suggesting reduced glr-1 signaling (PubMed:17761527, PubMed:20573983). Rab-10 lin-10 double mutant displays additive glr-1 trafficking defects indicating that they both regulate endocytic recycling of AMPA receptors to synapses, but most probably along distinct regulatory pathways (PubMed:17761527). Complete loss of dense core vesicles (DCVs) secretion of neuropeptides from DA/DB motoneurons, while synaptic ultrastructure and synaptic vesicles (SV) exocytosis as well as coelomocyte function are unaffected (PubMed:23100538). Severely reduced proximal dendritic arborization in multi-dendritic PVD sensory neurons, but minimal effect on dendritic branching and growth on the distal area of the PVD. The growth of PVD axon is normal. Reduced dendritic growth of the multi-dendritic FLP neurons, but no effect on the dendritic growth of unbranched dendrites of the OLL, AWB and …
messages: Late endosome membrane
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). Tbc-4 is a likely GAP of this rab (PubMed:23100538). Denn-4 is a putative GEF of this rab (PubMed:26633194).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:23100538, PubMed:26394140, PubMed:26633194). Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rme-1 (PubMed:16394106). Involved in the formation of the endosomal tubular network that is required for basolateral recycling of clathrin-independent endocytic cargo such as daf-4 in the intestine (PubMed:25301900). Required for the recruitment of cnt-1 effector to endosomal membranes in the intestinal epithelium, which is important for the regulation of levels of endosomal phosphatidylinositol-4,5-bisphosphate, a key phosphoinositide in membrane traffic, and for the recruitment of endosomal membrane-bending proteins, rme-1 and sdpn-1 (PubMed:22869721). Recruits the rab-5 GTPase-activating protein tbc-2 to endosomes where it then inactivates rab-5 resulting in removal of rab-5 from membranes, which is necessary for cargo transport from early endosomes to recycling endosomes in the basolateral intestine (PubMed:26393361). Regulates recycling of synaptic membrane AMPA glutamate receptor, glr-1, from intracellular endosomal compartments back to synapses in a cholesterol-dependent endocytosis pathway functioning after clathrin-independent endocytosis in command interneurons (PubMed:17761527). Regulates neuropeptide release from dense core vesicles (DCVs) of cholinergic motoneurons in cooperation with rab-5. They reciprocally recruit each other's inactivating GAP molecule leading to local exclusion of one or the other rab protein at the Golgi-endosomal interphase at a…

6239:CELE C27D11.1
gene id: 6239:CELE_C27D11.1
uniprot id: P34339
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

6239:CELE K12H4.3
gene id: 6239:CELE_K12H4.3
uniprot id: P34524
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

6239:CELE B0303.9
gene id: 6239:CELE_B0303.9
uniprot id: P34260
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Early endosome
messages: Late endosome
messages: Lysosome
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:25273556, PubMed:26783301, PubMed:27558849). Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in embryonic and adult intestinal cells (PubMed:24501423, PubMed:25273556). Required for endosome/lysosome fusion (PubMed:26783301, PubMed:27558849). Required for early embryonic development (PubMed:27558849).
messages: Probable component of the homotypic fusion and vacuole protein sorting (HOPS) complex consisting of the core class C Vps proteins vps-11, vps-16, vps-18, and which further associates with vps-33.1, vps-39 and vps-41 (PubMed:24501423, PubMed:25273556). Interacts with spe-39 (PubMed:19109425).
messages: Ubiquitously expressed at high levels in somatic tissues including the pharynx, muscles, hypodermis, neurons, coelomocytes and spermatheca (PubMed:27558849). Expressed in the intestine (PubMed:25273556, PubMed:27558849).
messages: Viable, and develop into fertile adults, but their progeny arrest before embryonic morphogenesis (PubMed:27558849). Defective endosome/lysosome size and fusion, and delayed endocytic trafficking to lysosomes in coelomocytes (PubMed:26783301, PubMed:27558849). Reduced number of gut granules in the adult intestine (PubMed:24501423, PubMed:27558849). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in the accumulation of lysosomal proteins such as lmp-1 in early endocytic compartments, and the formation of large late endosomes/lysosomes, but with simultaneous expression of rab-5- and rab-7-positive vesicles on the basal side of gut cells (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.2 results in defective protein trafficking to lysosomal compartments, and an irregular distribution of vesicles of various sizes throughout the gut cells. RNAi-mediated knockdown in a sand-1 mutant background results in no viable offspring (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 in a sand-1 mutant background rescues the large endosome phenotype and the defective protein trafficking to lysosomal compartments in the sand-1 single mutant, but still results in lethality (PubMed:25273556). Double knockout with tbc-2 or single knockout in a constitutively active rab-5 mutant background, rescues the large endosome formation defect in coelomocytes in the individual tbc-2 single and constitutively active rab-5 mutants (PubMed:27558849).

6239:CELE T02C5.5
gene id: 6239:CELE_T02C5.5
uniprot id: A0A1N7SYT0
uniprot id: A0A1N7SYT1
uniprot id: A0A1N7SYT8
uniprot id: A0A1N7SYU0
uniprot id: A0A1N7SYU4
uniprot id: A0A1N7SYU6
uniprot id: A0A1N7SYV5
uniprot id: A0A1N7SYV7
uniprot id: G5EFB0
uniprot id: Q86G45
uniprot id: Q8MPY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane

6239:CELE Y50D7A.9
gene id: 6239:CELE_Y50D7A.9
uniprot id: Q965T4
names: Similarity
messages: Belongs to the TACO1 family.

6239:CELE F17E5.1
gene id: 6239:CELE_F17E5.1
uniprot id: P54936
names: Function
names: Similarity
messages: Belongs to the MAGUK family.
messages: May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.

6239:CELE C27A12.8
gene id: 6239:CELE_C27A12.8
uniprot id: O01965
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity.
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Cytoplasm
messages: E3 ubiquitin-protein transferase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ubc-18 (By similarity). Acts with ubc-18 to regulate pharyngeal development (PubMed:16457801, PubMed:19521497).
messages: Expression is dynamic during early embryonic development, with ubiquitous somatic expression occurring between the 50- and 200-cell stage (PubMed:16457801). By the late proliferative phase of embryogenesis, expression is reduced, but maintained at high levels in muscle precursors (PubMed:16457801). Later in embryogenesis, moderate expression occurs in the lateral ectoderm (PubMed:16457801). Pharyngeal expression is very low at both the comma and 1.5-fold embryonic stages (PubMed:16457801). Expression is highest in muscle and neuronal cells in larvae and adults, including many of the amphid neurons that are proximal to the posterior bulb of the pharynx (PubMed:16457801). Consistent expression in cells of the somatic gonad including distal tip, sheath, and spermathecal cells, as well as in vulval cells undergoing morphogenesis (PubMed:16457801). Neuronal expression in the midbody includes the CAN, HSN, and ALM cells; neurons of the ventral and dorsal cords; and a number of posterior deirid neurons (PubMed:16457801). Expressed in all pairs of coelomocytes (PubMed:16457801).
messages: Interacts with ubiquitin-conjugating enzyme E2 ubc-18.
messages: Members of the RBR family are atypical E3 ligases. They interact with an E2 conjugating enzyme and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Nucleus
messages: RNAi-mediated knockdown on a pha-1 or on a lin-35;ubc-18 mutant background produces a high percentage of animals with the Pun (pharyngeal unattached) phenotype, whereby the pharynx fails to elongate and form an attachment to the anterior alimentary opening or buccal cavity.

6239:CELE F13D2.3
gene id: 6239:CELE_F13D2.3
uniprot id: Q19397
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE ZK1307.9
gene id: 6239:CELE_ZK1307.9
uniprot id: Q09651
names: Similarity
messages: Belongs to the CWC16 family.

6239:CELE W02B3.7
gene id: 6239:CELE_W02B3.7
uniprot id: Q09343
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK177.4
gene id: 6239:CELE_ZK177.4
uniprot id: Q09372
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R12B2.5
gene id: 6239:CELE_R12B2.5
uniprot id: Q21955
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Mediator complex subunit 15 family.
messages: Component of the Mediator complex (By similarity). Interacts with nhr-49, nhr-64 and sbp-1.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for regulated expression of genes controlling fatty acid desaturation by transcription factors including sbp-1 and nhr-49 (PubMed:16799563, PubMed:16651656). Involved in the response to simulated microgravity, in concert with sbp-1, probably acting in the intestine (PubMed:32448509).
messages: Expressed in the intestine and head neurons.
messages: Expressed throughout development.
messages: Expression increased by simulated microgravity.
messages: Nucleus

6239:CELE ZK112.7
gene id: 6239:CELE_ZK112.7
uniprot id: P34616
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 2 percent of mutants have a delay in anchor cell invasion. In 7 percent of zmp-1 and cdh-3 double mutants and in 25 percent of cdh-3, him-4 and zmp-1 triple mutants, anchor cell invasion is delayed.
messages: Basolateral cell membrane
messages: Cell adhesion protein involved in the control of epithelial morphogenesis (PubMed:9012534). Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development (PubMed:15960981).
messages: Cell junction
messages: Cell membrane
messages: Expressed in the anchor cell.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

6239:CELE B0001.4
gene id: 6239:CELE_B0001.4
uniprot id: Q17413
names: Similarity
messages: Belongs to the uridine kinase family.

6239:CELE F55A12.8
gene id: 6239:CELE_F55A12.8
uniprot id: O01757
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

6239:CELE Y66D12A.20
gene id: 6239:CELE_Y66D12A.20
uniprot id: Q95PZ9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
messages: Serine/threonine-protein kinase which is involved in spermatogenesis (PubMed:12019230, PubMed:8417991, PubMed:29879108). In spermatocytes, regulates meiosis and the localization and assembly of major sperm protein (MSP) into fibrous bodies (PubMed:12019230, PubMed:8417991). In addition, may suppress the initiation of spermiogenesis downstream of spe-8, spe-12, spe-27 and spe-29 (PubMed:12019230).

6239:CELE F41D3.1
gene id: 6239:CELE_F41D3.1
uniprot id: O45505
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F33A8.4
gene id: 6239:CELE_F33A8.4
uniprot id: O62214
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE C49A9.7
gene id: 6239:CELE_C49A9.7
uniprot id: O44148
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C25E10.8
gene id: 6239:CELE_C25E10.8
uniprot id: Q18157
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T01C8.7
gene id: 6239:CELE_T01C8.7
uniprot id: P24612
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Component of a non-voltage-gated amiloride-sensitive cation channel complex (also called the degenerin channel complex) composed of at least the mec-2, mec-4, mec-6 and mec-10 subunits; the complex mediates mechanotransduction in touch cells (PubMed:12478294). Interacts with mec-2, mec-6 and mec-10 (PubMed:12478294).
messages: Expressed in AVM, ALM, PVM and PLM touch neurons.
messages: Membrane
messages: Mutations in mec-4 results in the degeneration of a small set of neurons which typically swell to several times their normal diameter before they disappear, presumably due to lysis.
messages: Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity) (PubMed:8655580, PubMed:12478294). Negatively regulates the turning step of male mating behavior (PubMed:17611271).
messages: axon

6239:CELE B0303.15
gene id: 6239:CELE_B0303.15
uniprot id: P34264
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

6239:CELE Y48B6A.8
gene id: 6239:CELE_Y48B6A.8
uniprot id: Q9U295
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE F10F2.1
gene id: 6239:CELE_F10F2.1
uniprot id: Q19317
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat neurobeachin family.
messages: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells.
messages: Cytoplasm
messages: Expressed in vulval precursor cells and rectal epithelia in L2 and L3 larvae. In L4 larvae, expression is seen in intestinal epithelial cells.
messages: Interacts with RII subunit of PKA.
messages: Membrane
messages: Nucleus
messages: Worms lacking sel-2 exhibit a multivulva phenotype when combined with loss of lin-12.

6239:CELE T14G10.3
gene id: 6239:CELE_T14G10.3
uniprot id: Q22500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y45F10D.3
gene id: 6239:CELE_Y45F10D.3
uniprot id: O45947
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE T28A8.1
gene id: 6239:CELE_T28A8.1
uniprot id: H2L2J8
uniprot id: H2L2J9
uniprot id: Q9XU07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE K10H10.1
gene id: 6239:CELE_K10H10.1
uniprot id: O45678
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H03A11.1
gene id: 6239:CELE_H03A11.1
uniprot id: Q9XTW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM20 family.
messages: Golgi apparatus membrane
messages: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs.
messages: Secreted

6239:CELE R10E11.2
gene id: 6239:CELE_R10E11.2
uniprot id: C0HLB3
uniprot id: C0HLB4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Expressed in the H-shaped excretory cell, rectum, and a pair of cells posterior to the anus.
messages: Expressed ubiquitously. Higher levels of vha-2 are found in adult H-shaped excretory cell and rectum. Higher levels of vha-3 are found in gastrointestinal and hypodermal cells, as well as H-shaped excretory cell.
messages: High levels during embryogenesis, moderate levels during L1, L4 and adult stages and very low levels during L2 and L3 stages.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in necrotic cell death (PubMed:22157748). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (PubMed:29168500). This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (PubMed:29168500). The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates (PubMed:29168500). Lysosomal acidification also leads to changes in mitochondrial morphology and function (PubMed:29168500). Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity (PubMed:29168500). In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (PubMed:29168500).
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates. Lysosomal acidification also leads to changes in mitochondrial morphology and function. Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity. In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (By similarity).
messages: RNAi-mediated knockdown results in increased protein aggregation in the oocytes of sperm-deficient young adult females which is not eliminated by mating (PubMed:29168500). RNAi-mediated knockdown causes a reduction in the formation of neuron cell corpses in a hyperactive mec-4 mutant background (PubMed:22157748).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).
messages: Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream.

6239:CELE ZK1067.6
gene id: 6239:CELE_ZK1067.6
uniprot id: Q22708
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Expressed at higher level in embryos than in L1 larvae.
messages: Nucleus
messages: Worms lacking both symn-2 and mec-8 die during late embryogenesis. Lethality is probably due to defects in alternative splicing regulation.
messages: mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo-specific isoforms.

6239:CELE W03G11.2
gene id: 6239:CELE_W03G11.2
uniprot id: Q23151
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

6239:CELE H16D19.1
gene id: 6239:CELE_H16D19.1
uniprot id: G5ED09
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y56A3A.3
gene id: 6239:CELE_Y56A3A.3
uniprot id: Q9U228
names: Similarity
messages: Belongs to the MIF family.

6239:CELE R10D12.6
gene id: 6239:CELE_R10D12.6
uniprot id: P92009
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE F44G4.4
gene id: 6239:CELE_F44G4.4
uniprot id: D0VWM8
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: By hyperosmotic, oxidative and endoplasmic reticulum stress (at protein level).
messages: Cytoplasm
messages: Increased lifespan, slower growth rate, reduced egg-laying and reduced fertility (PubMed:22232551, PubMed:22792076). Defective locomotion and chemotaxis (PubMed:22232551, PubMed:25391662). Increased sensitivity to osmotic and oxidative stress (PubMed:22792076). Increased intronic A-to-I RNA editing and splicing abnormalities, which may contribute to the increased accumulation of double-stranded RNA observed in the nucleus of multiple tissues including gut, muscle and the anterior head region (PubMed:25391662).
messages: Interacts with chromobox protein homolog hpl-2; interaction may maintain localization of hpl-2 to gene bodies.
messages: Nucleus
messages: RNA-binding protein which regulates transcription, splicing and RNA-editing (PubMed:25391662). Limits the accumulation of double-stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs (PubMed:25391662). Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress (PubMed:22232551, PubMed:22792076). Involved in the regulation of physiological processes including aging, fertility, growth and locomotion (PubMed:22232551, PubMed:29760282). Plays a role in maintaining localization of chromobox protein homolog hpl-2 to gene bodies, perhaps acting via binding to nascent RNA transcripts (PubMed:29760282).
messages: Widely expressed in a range of tissues including body wall muscles, pharynx and neurons of the midbody in adults and larvae (PubMed:22232551, PubMed:22792076).

6239:CELE K12D9.7
gene id: 6239:CELE_K12D9.7
uniprot id: P91382
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C05B10.1
gene id: 6239:CELE_C05B10.1
uniprot id: V6CIV8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Cell membrane
messages: Dephosphorylates MAP kinase mpk-1.
messages: Expressed at low level in the proximal mitotic region and transition zone of germline cells and at the pachytene stage of meiotic prophase I.
messages: Expressed in vulva cell precursors. Expression is increased in P5.p and P7.p and their descendants during vulva induction. Expressed in syncytium hyp7 (PubMed:11161219). Expressed in germline cells (PubMed:12169634, PubMed:16319922).
messages: Pachytene exit and oocyte development are accelerated (PubMed:12169634, PubMed:21901106). These are associated with the accumulation of smaller oocytes in the proximal gonadal arm, the misalignment of oocytes in multiple rows, a premature nucleolus breakdown and an abnormal mpk-1 phosphorylation after pachytene exit and in diakinesis oocytes (PubMed:12169634, PubMed:21901106). 53 percent of mutants have endomitotic oocytes (PubMed:12169634). Embryo development is arrested before morphogenesis resulting in 50 percent embryonic lethality (PubMed:12169634). In adults, but not in larvae, reduced number of germ cells in the mitotic region of the gonad (PubMed:16319922). Moderate increase in the number of apoptotic corpses in the germline which is further enhanced following gamma irradiation (PubMed:21901106). Increased egl-1 mRNA expression in response to gamma irradiation (PubMed:21901106). Increased cep-1 expression in early pachytene germ cells (PubMed:21901106). Increased life span (PubMed:20624915). Increased MAP kinase activity (PubMed:11161219). Reduced levels of mpk-1 isoform b associated with an increase in mpk-1 isoform b phosphorylation (PubMed:21901106). In lip-1 and let-23, lip-1 and sem-5, and lip-1 and mpk-1 double mutants, normal vulva induction is restored (PubMed:11161219). In lip-1 and mpk-1 double mutants, normal oocyte development and fertility are restored (PubMed:12169634). lip-1 and puf-8 double mutant produces only sperm and has abnormal mpk-1 phosphorylation in the transition zone at the permissive temperature of 20 degrees Celsius. At the restrictive temperature of 25 degrees Celsius, has proximal germline tumors with high levels of mpk-1 phosphorylation (PubMed:22820175).
messages: The KIM (kinase interacting motif) region may be involved in the binding to MAP kinases.

6239:CELE ZK909.4
gene id: 6239:CELE_ZK909.4
uniprot id: Q94126
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Expression begins in the embryo and diminishes in larvae (PubMed:16310763). Expressed in the excretory duct cell, as well as other cells, at larval L3 stage (PubMed:16310763).
messages: Interacts with NFIL3 transcription factor homolog atf-2.
messages: Nucleus
messages: RNAi-mediated knockdown causes morphological defects in excretory duct cells. Reduces expression of transcription factor lin-48.
messages: Transcription factor (PubMed:8700229, PubMed:16310763). Required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons (PubMed:8700229). Negatively regulates the activity of ces-1 which in turn negatively regulates the activities of cell-killing genes (PubMed:8700229). Binds to the DNA sequence 5'-RTTACGTAAY-3' (PubMed:8700229). Involved in the development of the excretory duct cell, by positively modulating embryonic transcription of putative transcription factor lin-48, acting in concert with NFIL3 transcription factor homolog atf-2 (PubMed:16310763, PubMed:12231624). Positively modulates expression of neuropeptide pigment dispersing factor homologs pdf-1 and pdf-2 (PubMed:19686386).

6239:CELE T03F6.5
gene id: 6239:CELE_T03F6.5
uniprot id: Q9NDC9
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Component of a dynein-regulating complex composed of at least lis-1 and nud-2 (PubMed:20005871). Interacts with nud-2; the interaction is direct (PubMed:16996038).
messages: Defects lead to convulsions mimicking epilepsy, possibly due to altered neurotransmitter function (PubMed:15254012). RNAi-mediated knockdown results in arrest at the 50-100 cell stage, whereby egg and sperm pronuclei fails to migrate (PubMed:11685578). RNAi-mediated knockdown prevents the sperm-donated centrosome from leaving the posterior cortex in 1-cell embryos (PubMed:20599902). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells, but only in a small number of animals (PubMed:20005871). RNAi-mediated knockdown in a pam-1 mutant background restores anterior-posterior polarity (PubMed:20599902).
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Expressed in all classes of neurons in the ventral cord (PubMed:11685578, PubMed:16996038). Expressed in the multinucleate spermathecal valves and adult seam cells (PubMed:11685578).
messages: Nucleus envelope
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division (PubMed:11685578, PubMed:15331665). Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). Required for neuronal cell differentiation (PubMed:15254012).
messages: centrosome
messages: cytoskeleton
messages: kinetochore

6239:CELE Y50D7A.6
gene id: 6239:CELE_Y50D7A.6
uniprot id: Q965T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
messages: Component of the kinesin II motor complex (composed of kap-1 and the heterodimeric motor proteins klp-11 and klp-20) which is required for intraflagellar transport (IFT) (PubMed:20833139, PubMed:20498083). Heterodimerizes with klp-11 to form a 'processive' molecular motor upon IFT cargo binding, which, within the kinesin II motor complex, binds to and moves along microtubules in a unidirectional manner (without dissociation of the heterodimer), and in turn, is responsible for the IFT of cargo (PubMed:20498083). Specifically, the kinesin II motor complex, together with the kinesin motor protein osm-3 moves along microtubules and is required for anterograde IFT along the middle segment of the sensory neuron cilia (PubMed:17000880, PubMed:20833139, PubMed:28479320). In particular, the kinesin II motor complex delivers specific ciliary cargo proteins such as che-3 which are related to motility to ciliary tips (PubMed:28479320). This is likely mediated by IFT complexes A and B (PubMed:28479320).
messages: Component of the kinesin II motor complex, a heterotrimeric complex composed of kap-1, klp-11 and klp-20 (PubMed:17000880, PubMed:20833139, PubMed:20498083, PubMed:28479320). Interacts (via C-terminus) with klp-11 (via C-terminus) to form a heterodimer (PubMed:20498083, PubMed:21917588). Furthermore, within the heterodimer, the C-termini of klp-20 and klp-11 interact to form a coiled coil (stalk) or tail domain, and this is necessary for association with kap-1, and kinesin II motor complex activity upon IFT cargo binding (PubMed:20498083, PubMed:21917588). Prior to cargo binding, the klp-11/klp-20 heterodimer is autoinhibited by the tail domain of the heterodimer, which folds onto the kinesin motor domain (PubMed:20498083). Cargo binding to the heterodimer relieves the autoinhibition, and allows for an extended conformation of the tail domain, and function of the heterodimer (PubMed:20498083).
messages: cilium
messages: cytoskeleton

6239:CELE C44E4.3
gene id: 6239:CELE_C44E4.3
uniprot id: O01804
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6239:CELE M04D8.2
gene id: 6239:CELE_M04D8.2
uniprot id: Q21508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE T05G11.6
gene id: 6239:CELE_T05G11.6
uniprot id: Q9XXJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE E04A4.5
gene id: 6239:CELE_E04A4.5
uniprot id: O44477
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

6239:CELE C47G2.3
gene id: 6239:CELE_C47G2.3
uniprot id: Q9NAQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex, whose core is composed of tim-22, associated with the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of tim-9/tin-9.1 and tim-10/tin-10 (By similarity).
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
messages: Mitochondrion inner membrane

6239:CELE T02B5.1
gene id: 6239:CELE_T02B5.1
uniprot id: O01302
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE B0207.4
gene id: 6239:CELE_B0207.4
uniprot id: O01427
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: Chromosome
messages: Component of the CPC complex which consists of icp-1; csc-1; bir-1 and air-2 (PubMed:12707312). Within the complex, interacts with icp-1; csc-1 and bir-1 (PubMed:12707312, PubMed:11050385). Interacts with zen-4 (PubMed:11050384). Interacts with tlk-1 and bmk-1 (PubMed:15548597, PubMed:15916946).
messages: Midbody
messages: Phosphorylated. Increased phosphorylation upon chromatin obstructions at anaphase.
messages: Present during gametogenesis and throughout embryogenesis (at protein level).
messages: RNAi-mediated knockdown disrupts the localization of the condensin subunit smc-4 to mitotic chromosomes (PubMed:11914278). RNAi-mediated knockdown causes failure in mitotic chromosome segregation and cytokinesis, leading to aneuploidy (PubMed:11914278, PubMed:12213836).
messages: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis (PubMed:12707312, PubMed:11050385, PubMed:10983970, PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation (PubMed:12707312, PubMed:10983970). Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis (PubMed:18923084). Required for histone H3 'Ser-10' phosphorylation (PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384, PubMed:11050385, PubMed:10983970, PubMed:12015116, PubMed:11940606). Phosphorylates tlk-1 at 'Ser-634', which enhances its activity (PubMed:15916946). Phosphorylates zen-4 at 'Ser-680'(PubMed:15854913). Required for the recruitment of bub-1 to the ring-shaped domain between chromosomes during meiotic anaphase I (PubMed:20729837). Also required for the localization of the condensin I complex subunit smc-4 to mitotic chromosomes (PubMed:11914278). Acts at the spindle midzone and the midbody to prevent cleavage furrow regression upon chromatin obstructions during cytokinesis (PubMed:12213836, PubMed:23684975).
messages: cytoskeleton
messages: spindle

6239:CELE C05C10.6
gene id: 6239:CELE_C05C10.6
uniprot id: G5EES6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm
messages: Expressed in intestine (at protein level).
messages: Interacts with cdc-48.1.
messages: Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2.
messages: The PFU domain mediates interaction with ubiquitin.
messages: The PUL domain mediates the interaction with cdc-48.1 and/or cdc-48.2 C-terminus.

6239:CELE Y76B12C.2
gene id: 6239:CELE_Y76B12C.2
uniprot id: Q9N4C3
names: Similarity
messages: Belongs to the XPC family.

6239:CELE F34D6.3
gene id: 6239:CELE_F34D6.3
uniprot id: O17185
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Expressed in body wall muscles from 3.5-fold stage of embryogenesis with highest levels in late embryos and L1 stage larvae. Lower levels persist to adulthood.
messages: Low levels along surface of body-wall muscle cells, in vulval and intestinal muscles and, more weakly, in anal depressor and sphincter muscles. Also expressed in a subset of head neurons.
messages: May form a complex with the regulatory subunits unc-93 and sup-10.
messages: Membrane
messages: Potassium channel involved in coordination of muscle contraction (PubMed:14534247). Activity is regulated by sup-18 (PubMed:24586202).
messages: Uncoordinated rubber band response is phenocopied by exposure to the unc-49 agonist muscimol.

6239:CELE F36F12.1
gene id: 6239:CELE_F36F12.1
uniprot id: O76403
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE W04G3.6
gene id: 6239:CELE_W04G3.6
uniprot id: G5EC30
uniprot id: G5EE27
uniprot id: G5EFX9
uniprot id: G5EGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE B0302.1
gene id: 6239:CELE_B0302.1
uniprot id: Q10925
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
messages: Cytoplasm
messages: Defective in transport of silencing RNAs but not defective in execution of RNAi. Marginal enhancement of cell-autonomous RNAi. Mildly defective in silencing the intestine-expressed gene, act-5.
messages: Expressed throughout all developmental stages.
messages: The kinase domain is required for import of dsRNA into cells.
messages: Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues.
messages: Ubiquitously present in all tissues tested. Expressed in the somatic cells of gut, pharynx, body wall muscle, neurons, skin and excretory canal cells.

6239:CELE Y66H1A.4
gene id: 6239:CELE_Y66H1A.4
uniprot id: Q9TYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE F46H6.2
gene id: 6239:CELE_F46H6.2
uniprot id: H2KYI9
uniprot id: Q7Z299
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

6239:CELE F37A8.5
gene id: 6239:CELE_F37A8.5
uniprot id: Q9U3G6
names: Similarity
messages: Belongs to the yippee family.

6239:CELE T13F2.1
gene id: 6239:CELE_T13F2.1
uniprot id: G5EG11
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Can function as a Delta(5) fatty acid desaturase and behaves as a (8-3) desaturase. Introduces a double bond in the fatty acid chain 5 carbons away from carboxy terminal to biosynthesize polyunsaturated fatty acids (PUFAs) endogenously (PUFAs are essential for membrane structure and many cellular and physiological processes). Acts on a variety of substrates such as dihomo-gamma-linoleoyl-CoA ((8Z,11Z,14Z)-eicosatrienoyl-CoA, 20:3n-6) to generate arachidonoyl-CoA ((5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA, 20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position like (11Z,14Z,17Z)-eicosatrienoyl-CoA (20:3n-3) to produce (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA (20:4n-3) (PubMed:9845325, PubMed:9917342, PubMed:11972048, PubMed:26806391). Unlike plants, Caenorhabditis elegans desaturases seem to use fatty acyl-CoAs as substrates (By similarity).
messages: HPO-19 and T05H4.4 are cytochrome b5 reductases required for PUFA desaturation in Caenorhabditis elegans. HPO-19 knockdown or mutation alters FAT-4 desaturase activity.
messages: Membrane
messages: The fat-4 mutants lack detectable Delta(5)-unsaturated fatty acids.

6239:CELE ZC443.6
gene id: 6239:CELE_ZC443.6
uniprot id: G5EGK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE C46H11.8
gene id: 6239:CELE_C46H11.8
uniprot id: Q9GYJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y17G7B.6
gene id: 6239:CELE_Y17G7B.6
uniprot id: E1NZ07
uniprot id: E1NZ08
uniprot id: E1NZ09
uniprot id: Q9XXI2
names: Similarity
messages: Belongs to the globin family.

6239:CELE Y71H2AM.25
gene id: 6239:CELE_Y71H2AM.25
uniprot id: Q2AAB9
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE R07H5.1
gene id: 6239:CELE_R07H5.1
uniprot id: Q93930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

6239:CELE T28D9.4
gene id: 6239:CELE_T28D9.4
uniprot id: Q10023
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R53.6
gene id: 6239:CELE_R53.6
uniprot id: Q22019
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of gins1, gins2, gins3 and gins4.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

6239:CELE C50H11.15
gene id: 6239:CELE_C50H11.15
uniprot id: O16482
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F09D1.1
gene id: 6239:CELE_F09D1.1
uniprot id: O44787
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C10C6.6
gene id: 6239:CELE_C10C6.6
uniprot id: P90747
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.

6239:CELE W08D2.8
gene id: 6239:CELE_W08D2.8
uniprot id: G5EBM6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE ZK909.2
gene id: 6239:CELE_ZK909.2
uniprot id: P21137
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Binding of cAMP to kin-2 regulatory subunits induces dissociation of the heterotetramer. The released catalytic subunits are active and able to phosphorylate their substrates.
messages: Essential for larval development (PubMed:22887816). Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons (PubMed:24086161). Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells (PubMed:22887816).
messages: Expressed at low levels in the embryo. Expression increases after hatching and during larval stages and, despite a decrease, remains high in adults (at protein level).
messages: Heterotetramer composed of two regulatory subunits and two catalytic subunits.
messages: Isoform h and isoform j are myristoylated.
messages: Isoforms a and b: May play a role in the regulation of neuromuscular junctions.
messages: RNAi-mediated knockdown of isoforms a and b in neurons shows a temperature-sensitive adult onset paralysis of the distal part of the body resulting in the loss of backward movements and an inability to lay eggs. RNAi-mediated knockdown of isoforms f and k results in no obvious phenotype.

6239:CELE F47F2.1
gene id: 6239:CELE_F47F2.1
uniprot id: Q7JP68
names: Developmental Stage
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.
messages: No obvious expression before embryo hatching but is expressed at later stages (at protein level).

6239:CELE T19D12.6
gene id: 6239:CELE_T19D12.6
uniprot id: Q22574
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T03E6.7
gene id: 6239:CELE_T03E6.7
uniprot id: O45734
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C1 family.
messages: Cysteine protease which plays an essential role in the degradation of proteins in lysosomes (PubMed:15456850, PubMed:24829385). During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome-like structure where a slow and controlled degradation of yolk proteins occurs (PubMed:15456850, PubMed:24829385). In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes (PubMed:24829385). In embryos, required for the degradation of endocytic and autophagic cargos (PubMed:24829385). In embryos, may play a role in the degradation of lipid-containing droplets (PubMed:26773047). Required for larval development (PubMed:11707440, PubMed:15456850).
messages: Cytoplasmic granule
messages: Endosome
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:11707440, PubMed:15456850, PubMed:16857685, PubMed:24829385). Expression transiently increases during early embryonic stages and prior to the larval L1/L2, L2/L3, L3/L4 and L4/adult molts (PubMed:11707440, PubMed:16857685). Highest expression in adults (PubMed:11707440). In embryos, expressed in gut cells (PubMed:11707440). In larvae, expressed in the hypodermis, intestine and pharyngeal lining (PubMed:11707440). In molting larvae, expressed in the old and new cuticle (PubMed:11707440).
messages: Expressed in intestine, pharynx posterior bulb, hypodermis and cuticle (at protein level) (PubMed:11707440, PubMed:24829385). Expressed in germ cells, developing oocytes, sheath cells surrounding germ cells and oocytes, and in the eggshell (at protein level) (PubMed:11707440, PubMed:16857685).
messages: Lysosome
messages: RNAi-mediated knockdown causes early embryonic lethality with embryos arrested at the 100-200 cell stage (PubMed:11707440). The few larvae which survive have incomplete gut development and die at the L1 stage (PubMed:11707440). RNAi-mediated knockdown at the L3 larval stage causes a growth delay, adults are shorter and thinner, and lay fewer eggs (PubMed:11707440).
messages: Secreted
messages: phagosome

6239:CELE Y39E4A.2
gene id: 6239:CELE_Y39E4A.2
uniprot id: O45923
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: By B.thuringiensis pore-forming toxin Cry5B (PubMed:15256590). Isoform a: Not induced by zinc. Isoform b: Induced by zinc specifically in intestinal cells (PubMed:23717214).
messages: Cytoplasmic vesicle membrane
messages: Isoform a: Expressed in the hypodermis and the intestine. Isoform b: Expressed in the intestine, head neurons, seam cells, hypodermis, and the vulva.
messages: Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc (PubMed:23717214). Involved in cadmium resistance, possibly by promoting its transport from cells (PubMed:15256590). Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway (PubMed:15256590).
messages: RNAi-mediated knockdown causes hypersensitivity to low, chronic doses of the B.thuringiensis pore-forming toxin Cry5B and heavy metal Cd(2+) exposure.

6239:CELE Y105E8B.1
gene id: 6239:CELE_Y105E8B.1
uniprot id: A0A0K3AQS9
uniprot id: A0A0K3AQT4
uniprot id: A0A0K3ARB5
uniprot id: A0A0K3ARC0
uniprot id: A0A0K3ATR6
uniprot id: A0A0K3ATS1
uniprot id: A0A0K3AUC0
uniprot id: A0A0K3AUC2
uniprot id: A0A0K3AWP0
uniprot id: Q22866
uniprot id: Q27249
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tropomyosin family.
messages: Cytoplasm
messages: I band
messages: Isoform a and isoform d are expressed in body wall muscles, vulva, anus muscles and male tail muscles (PubMed:7666414). Located to the myofibrils of thin actin filaments (PubMed:11901171, PubMed:17684058).
messages: Isoform e is expressed in the pharyngeal muscles, germline tissue and intestinal cells. Isoform c is expressed in the pharyngeal and intestinal cells.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction (PubMed:9113409, PubMed:11901171). Involved in muscle actin filament organization and muscle arm extension and morphology (PubMed:15930100). Protects actin filaments from depolymerization by unc-60 in vitro (PubMed:17684058). Also has a role in male mating behavior by regulating the copulatory spicules (PubMed:16399684). Binds to F-actin (PubMed:11901171).
messages: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin.
messages: Worms have 50-75% embryonic lethality (PubMed:15930100). Those that survive body wall interference have abnormal body morphology and uncoordinated movements, and those that survive pharynx interference have deformed pharynges and gut regions (PubMed:15930100). RNAi-mediated knockdown results in a wavy appearance of the actin filaments in adult body wall muscles (PubMed:17684058).
messages: Worms have 50-75% embryonic lethality. Those that survive body wall interference have abnormal body morphology and uncoordinated movements, and those that survive pharynx interference have deformed pharynges and gut regions.

6239:CELE C16B8.1
gene id: 6239:CELE_C16B8.1
uniprot id: G5EGT9
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed in vulva cell precursors (VPC) P5.p, P6.p and P7.p, and their descendants during L3 and L4 larval stages.
messages: Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development (PubMed:15369677, PubMed:15649465). Regulates pop-1 asymmetric distribution in P7.p and its daughter cells (PubMed:15649465). Plays a role in the migration of ALM neurons during embryogenesis (PubMed:18622031).
messages: May lack kinase activity. The human ortholog has been shown to have impaired catalytic activity with an inability to undergo autophosphorylation or to phosphorylate substrates.

6239:CELE F57F10.1
gene id: 6239:CELE_F57F10.1
uniprot id: G5EBE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

6239:CELE F09G2.6
gene id: 6239:CELE_F09G2.6
uniprot id: O17401
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y38E10A.8
gene id: 6239:CELE_Y38E10A.8
uniprot id: Q9NAK3
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F54C8.4
gene id: 6239:CELE_F54C8.4
uniprot id: P34442
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

6239:CELE C25F6.3
gene id: 6239:CELE_C25F6.3
uniprot id: Q18164
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil.
messages: Worms lacking dpyd-1 exhibit increased sensitivity (decreased survival) to the chemotherapeutic drug 5-fluorouracil.

6239:CELE C14A4.15
gene id: 6239:CELE_C14A4.15
uniprot id: Q86GC5
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T08A9.11
gene id: 6239:CELE_T08A9.11
uniprot id: H2KYJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y92C3B.3
gene id: 6239:CELE_Y92C3B.3
uniprot id: Q8MXS1
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Plays a role in apical endocytosis/recycling (PubMed:24843160). May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells (PubMed:24843160).
messages: RNAi-mediated knockdown results in disrupted clearance of intracellular pathogen N.parisii from intestinal cells.

6239:CELE Y57G7A.9
gene id: 6239:CELE_Y57G7A.9
uniprot id: O76629
names: Similarity
messages: Belongs to the globin family.

6239:CELE LLC1.3
gene id: 6239:CELE_LLC1.3
uniprot id: O17953
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Mitochondrion matrix
messages: The active site is a redox-active disulfide bond.

6239:CELE B0280.4
gene id: 6239:CELE_B0280.4
uniprot id: P41995
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Expressed in the gut during embryogenesis (PubMed:14648222, Ref.3). Expressed in presumptive intestinal cells and in unidentified cells in the head prior to embryonic elongation (PubMed:14648222). Highly expressed in the most anterior intestinal cell from 1.25-fold stage to 2.5-fold stage (elongating) embryos, but weakly expressed in the remaining intestine in embryos at the 1.25-fold stage (PubMed:14648222). Expressed in additional unidentified cells in the head in 2-fold stage embryos (PubMed:14648222).
messages: May function as transcription regulator (Probable). Essential for larval development (PubMed:14648222, Ref.3). Required for morphogenesis and function of the digestive tract (PubMed:14648222).
messages: Nucleus
messages: RNAi-mediated knockdown results in defects in feeding, and failed growth and development eventually leading to lethality at the larval stage of development. Morphological and functional defects around the pharyngeal intestinal valve and intestine boundary with multiple cavities surrounding the isthmus of the pharynx in 1 to 2 day old larvae, and accumulation of ingested bacteria in the anterior intestine.

6239:CELE Y37E3.11
gene id: 6239:CELE_Y37E3.11
uniprot id: A9D2X7
uniprot id: Q9BKU2
uniprot id: X5LPW7
uniprot id: X5LPX5
uniprot id: X5LV72
uniprot id: X5LX84
uniprot id: X5M5S8
names: Similarity
messages: Belongs to the cytidylyltransferase family.

6239:CELE C39H7.1
gene id: 6239:CELE_C39H7.1
uniprot id: Q18553
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE R11A8.4
gene id: 6239:CELE_R11A8.4
uniprot id: Q21921
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Expressed in neurons of the head and tail from embryo to adult. Expressed in the hypodermis from the three-fold stage of embryogenesis; expression in the hypodermis subsequently decreases at L3 and is undetectable in adults.
messages: Interacts with ftt-2 and par-5 (PubMed:16777605). Interacts with daf-16 following heat-shock, which causes daf-16 to accumulate in the nucleus (PubMed:16777605). Interaction with daf-16 is promoted by ftt-2 (PubMed:16777605). Interacts with transcriptional coregulator hcf-1 (PubMed:21909281).
messages: NAD-dependent deacetylase (By similarity). Involved in metabolism, apoptosis, response to oxidative stress, response to DNA damage, and determination of lifespan (PubMed:16777605, PubMed:16280150, PubMed:16256736, PubMed:21909281, PubMed:23509272, PubMed:24077178, PubMed:27514077, PubMed:26598553, PubMed:27650246). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites (PubMed:22393255). Plays a role in germ cell and somatic cell apoptosis in response to DNA damage (PubMed:26598553, PubMed:27650246). Functions upstream of daf-16/Forkhead box protein O in the Insulin/IGF-1-like signaling (IIS) mediated pathway, promoting daf-16 mediated transcriptional activation and increased lifespan (PubMed:16777605, PubMed:16280150). May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER) (PubMed:16256736, PubMed:16280150). Functions upstream of transcriptional coregulator hcf-1, perhaps acting independently of the IIS mediated pathway, to modulate lifespan and oxidative stress response (PubMed:21909281). Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity (PubMed:24077178). Plays a role in ascaroside-mediated longevity and stress resistance (PubMed:23509272).
messages: Nucleus
messages: Reduces the longevity-extending effects of nicotinic acid when exposed to 1 mM nicotinic acid (PubMed:24077178). Defective ascaroside-mediated responses with neither ascr#2 nor ascr#3 inducing lifespan extension or conferring thermotolerance (PubMed:23509272). Reduced germ cell apoptosis in the gonadal arms following DNA damage induced by UV-irradiation (PubMed:26598553). RNAi-mediated depletion results in an increase of 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites (PubMed:22393255).

6239:CELE F26A3.8
gene id: 6239:CELE_F26A3.8
uniprot id: G3MU40
uniprot id: G5ECM1
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE T23C6.1
gene id: 6239:CELE_T23C6.1
uniprot id: O02042
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F59C6.7
gene id: 6239:CELE_F59C6.7
uniprot id: Q93833
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IFT57 family.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:12651157, PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for the formation of chemosensory cilia that detect chemosensory cues (PubMed:12651157).
messages: Regulated by the RFX-type transcription factor daf-19.
messages: Worms display defects in ciliary structure resulting in defects in ability and osmotic avoidance behavior. It also affects the localization of IFT complex B proteins, osm-5 and osm-6. Shortened axonemes of all classes of sensory cilia in the head. Required for mating.
messages: cilium axoneme

6239:CELE C44H4.5
gene id: 6239:CELE_C44H4.5
uniprot id: G5EEM6
names: Caution
names: Disruption Phenotype
names: Function
names: Subunit
messages: Interacts with mom-4; the interaction enhances mom-4 kinase activity.
messages: Involved in the Wnt signaling pathway by regulating mom-4 kinase activity.
messages: Lacks several key residues involved in metal-binding and catalytic activity, therefore has lost phosphatase activity.
messages: RNAi-mediated knockdown causes no obvious phenotype. Results in a 3-fold increase in the number of animals lacking a gut in a mom-4 (or11) mutant background.

6239:CELE F59B10.6
gene id: 6239:CELE_F59B10.6
uniprot id: Q09954
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F28C12.7
gene id: 6239:CELE_F28C12.7
uniprot id: O17846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F58B3.8
gene id: 6239:CELE_F58B3.8
uniprot id: Q20971
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE F37B4.7
gene id: 6239:CELE_F37B4.7
uniprot id: O45166
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane
messages: Unlike folt-1, does not appear to act as a folate transporter.

6239:CELE F38B2.4
gene id: 6239:CELE_F38B2.4
uniprot id: Q20140
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

6239:CELE F25E2.5
gene id: 6239:CELE_F25E2.5
uniprot id: Q95QI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dwarfin/SMAD family.
messages: Chromosome
messages: Cytoplasm
messages: Interacts with R-SMADs daf-8 and daf-14 (PubMed:20081192). Interacts with daf-14 in a daf-8 dependent manner (PubMed:20081192). May interact with daf-5 (PubMed:14681186).
messages: Nucleus
messages: Transcriptional regulator and common SMAD (co-SMAD), required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:9334330). Probable component of transcriptional regulatory complex with SMAD protein daf-5 (PubMed:14681186). Acts antagonistically to SMAD signaling downstream of TGF-beta-like daf-7 signaling (PubMed:20081192). Binds to the 5'-GTCTG-3' motif found in regulatory regions and may modulate the expression of genes involved in TGF-beta-like daf-7 and Notch lag-2 signaling (PubMed:20081192, PubMed:9834189, PubMed:28811311). May regulate gene expression outside the dauer pathway (PubMed:9834189).

6239:CELE C56C10.9
gene id: 6239:CELE_C56C10.9
uniprot id: Q18887
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

6239:CELE F42D1.2
gene id: 6239:CELE_F42D1.2
uniprot id: Q93703
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Expressed in the muscle (PubMed:18227072). Expressed in the hypodermis and intestine (PubMed:18227072, PubMed:24385923).
messages: Homodimer.
messages: RNAi-mediated knockdown increases lifespan by 17.8%, and reduces tyrosine aminotransferase activity by 75% thus increasing tyrosine levels (PubMed:24385923, PubMed:31043480). RNAi-mediated knockdown delays reproductive adult development in response to oxidative stress induced by the superoxide paraquat (PubMed:31043480). RNAi-mediated knockdown increases dauer formation in eak-4 mg348, eak-3 mg344, eak-5 mg337, eak-2 mg433, or eak-7 tm3188 mutant backgrounds at 25 degrees Celsius (PubMed:24385923). RNAi-mediated knockdown increases aak-2 phosphorylation, but does not impair energy production in a eak-4 mg348 mutant background (PubMed:24385923). RNAi-mediated knockdown results in a reduced lifespan in an aak-2 gt33 mutant background (PubMed:24385923). RNAi-mediated knockdown results in reduced dauer formation in an eak-4 mg348 and aak-2 gt33 mutant background (PubMed:24385923). RNAi-mediated knockdown extends the lifespan of eak-7 tm3188 mutants (PubMed:24385923). RNAi-mediated knockdown together with fah-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072).
messages: Transaminase involved in tyrosine breakdown (PubMed:24385923, PubMed:31043480). Converts tyrosine to p-hydroxyphenylpyruvate (PubMed:31043480). Has no transaminase activity towards phenylalanine (PubMed:31043480). Plays protective role against oxidative stress, metabolizing meta-tyrosine and negatively regulating its accumulation (PubMed:31043480). Plays a role in modulating the daf-2/insulin receptor-like transduction pathway through regulating tyrosine levels (PubMed:24385923). Negatively regulates dauer formation (PubMed:24385923). Plays a role in longevity (PubMed:24385923, PubMed:31043480).
messages: Up-regulated in response to oxidative stress.

6239:CELE B0563.6
gene id: 6239:CELE_B0563.6
uniprot id: A8WFI5
uniprot id: Q11082
uniprot id: Q8MQF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Not known. Putative receptor.

6239:CELE T07C4.8
gene id: 6239:CELE_T07C4.8
uniprot id: P41958
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abundant expression is seen in embryos and adults (PubMed:7907274). Expressed in embryos prior to elongation, at comma stage, at 1.5-fold stage and in adult gonad (PubMed:17021039).
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endomembrane system
messages: Interacts with asymmetric homodimer ced-4; the interaction sequesters ced-4 (PubMed:9024666, PubMed:9027313, PubMed:15383288, PubMed:16208361). Interacts with egl-1; the interaction results in ced-4 release (PubMed:9604928, PubMed:12894216, PubMed:15383288). Interacts with dre-1; the interaction inhibits ced-9 activity, either directly or indirectly (PubMed:23431138). Interacts with dct-1 (PubMed:11114722). May form a complex composed of ced-9, ced-4 and mac-1 (PubMed:10101135).
messages: Mitochondrion membrane
messages: Perikaryon
messages: Plays a major role in programmed cell death (PCD, apoptosis) (PubMed:7907274, PubMed:10688797). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9024666, PubMed:9027313, PubMed:9604928, PubMed:12894216, PubMed:15383288, PubMed:16208361). During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway (PubMed:26074078).
messages: Synapse

6239:CELE R04F11.4
gene id: 6239:CELE_R04F11.4
uniprot id: B0M0M8
uniprot id: K8ESB6
uniprot id: K8F7Q8
uniprot id: Q21729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y41E3.3
gene id: 6239:CELE_Y41E3.3
uniprot id: O62433
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

6239:CELE Y37E11AR.6
gene id: 6239:CELE_Y37E11AR.6
uniprot id: G5EEE7
uniprot id: U4PQX3
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K10B3.7
gene id: 6239:CELE_K10B3.7
uniprot id: P17330
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in Caenorhabditis elegans.

6239:CELE R11H6.2
gene id: 6239:CELE_R11H6.2
uniprot id: O45719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

6239:CELE F15A4.9
gene id: 6239:CELE_F15A4.9
uniprot id: O17812
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C52B9.1
gene id: 6239:CELE_C52B9.1
uniprot id: Q22942
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the choline/ethanolamine kinase family.
messages: Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline.
messages: Homodimer (PubMed:12791258, PubMed:12758145). A small proportion exists as higher oligomers (PubMed:12758145).
messages: Inhibited by Ca(2+). Mild inhibition by high levels of Mg(2+)(>10 mM) (PubMed:14960577).
messages: Mn(2+) is a poor substitute (PubMed:12758145).

6239:CELE ZC250.2
gene id: 6239:CELE_ZC250.2
uniprot id: O01878
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y110A2AL.8
gene id: 6239:CELE_Y110A2AL.8
uniprot id: H2L0G5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the patched family.
messages: Embryonic lethal with embryos displaying a fluid-filled appearance and dying at hatching. RNAi-mediated knockdown results in high levels of embryonic and larval lethality. Dead and dying mutants do not respond to touch, display extensive vacuolation, molting defects which include unshed cuticles and in particular male specific molting defects that prevent unfurling of the mature tail rays. Surviving mutants are shorter in length and display defective egg-laying and abnormal vulval morphogenesis.
messages: Expressed in the hypodermis of embryos prior to hatching and expression is enhanced in the hypodermis before each molt. Expressed during larval development in the excretory duct at the L1 stage, and during morphogenesis of the somatic gonad and vulva during the L3 and L4 stages with prominent expression in the uterine seam cell and toroidal vulE and vulD cells.
messages: In males, expressed in the precursor and mature sensory rays, the cloaca, and pre-anal ganglia and cephalic neurons. Also expressed in five cells in the valve region between the seminal vesicle and vas deferens of the somatic gonad.
messages: Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting.
messages: adherens junction

6239:CELE F25F8.2
gene id: 6239:CELE_F25F8.2
uniprot id: Q17328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.
messages: Cell membrane
messages: Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817).
messages: Pentamer (By similarity). Homooligomer that can form functional heterooligomers with glc-1 (PubMed:7935817).
messages: Postsynaptic cell membrane

6239:CELE T09B9.1
gene id: 6239:CELE_T09B9.1
uniprot id: Q7JMM5
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

6239:CELE C34B2.10
gene id: 6239:CELE_C34B2.10
uniprot id: O44953
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS1 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
messages: Endoplasmic reticulum membrane

6239:CELE F25D1.1
gene id: 6239:CELE_F25D1.1
uniprot id: Q19775
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Approximately 15 percent of mutants have an overextension of the axon of ALM neurons which terminates with a small hook. Approximately 30 percent of mutants have an overextension of the axon of PLM neurons. Approximately 10 percent of mutants lack synaptic branch extension in PLM neurons.
messages: Belongs to the PP2C family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Expressed in neurons of the nerve ring and motor neurons of the ventral nerve cord.
messages: Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3.
messages: Synapse

6239:CELE F54G8.4
gene id: 6239:CELE_F54G8.4
uniprot id: Q03601
names: Disruption Phenotype
names: Subunit
messages: Double knockout with par-2 mutant (it5ts) partially suppresses the lethality phenotype of the par-2 mutant (it5ts) at 25 degrees Celsius.
messages: Interacts with ubc-13.

6239:CELE F16H6.1
gene id: 6239:CELE_F16H6.1
uniprot id: Q9XV91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0365.6
gene id: 6239:CELE_B0365.6
uniprot id: P90732
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F59E11.10
gene id: 6239:CELE_F59E11.10
uniprot id: H2L098
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F36D3.2
gene id: 6239:CELE_F36D3.2
uniprot id: O45460
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C34E10.3
gene id: 6239:CELE_C34E10.3
uniprot id: P46578
names: Function
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.
messages: Regulator of mitophagy.

6239:CELE F40D4.8
gene id: 6239:CELE_F40D4.8
uniprot id: Q9XV24
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C09E8.1
gene id: 6239:CELE_C09E8.1
uniprot id: H2KYM8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0286.4
gene id: 6239:CELE_B0286.4
uniprot id: B2MZA9
uniprot id: Q10923
uniprot id: Q95QZ4
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

6239:CELE C06A6.3
gene id: 6239:CELE_C06A6.3
uniprot id: Q17687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

6239:CELE Y53F4B.4
gene id: 6239:CELE_Y53F4B.4
uniprot id: Q9NAA7
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: RNAi-mediated knockdown increases lifespan and stress resistance (PubMed:25635753). RNAi-mediated knockdown results in a higher frequency of gene products that arise as a consequence of increased ribosomal frameshifting in response to osmotic stress induced by high salt concentrations in adults (PubMed:30977983). RNAi-mediated knockdown does not result in fertility defects (PubMed:33283887).
messages: S-adenosyl-L-methionine-dependent methyltransferase which methylates the carbon-5 position of cytosine 2381 to 5-methylcytosine (m5C2381) in 26S rRNA (PubMed:25635753, PubMed:33289480, PubMed:33283887). Plays a role in the production of mature 5S, 5.8S, 18S and 26S rRNAs and promotes the processing of the internally transcribed spacer 2 (ITS2), which separates the 5.8S and 26S rRNAs on large pre-rRNA precursors (PubMed:33289480). May play a role in the translation of leucine and proline codons (Probable). May play a role in maintaining ribosomal frameshifting in response to osmotic stress (PubMed:30977983). Not required for global translation (PubMed:33289480).

6239:CELE F37C12.2
gene id: 6239:CELE_F37C12.2
uniprot id: Q20123
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EI24 family.
messages: Cytoplasm
messages: Early autophagic structures and lgg-1 puncta form an irregular shape and clump together (PubMed:20550938). RNAi-mediated knockdown results in increased lgg-2-positive autophagosomes following fertilization and at later embryonic stages (PubMed:24374177).
messages: Expressed in pharyngeal and body wall muscles and intestine cells.
messages: Involved in autophagy (PubMed:20550938, PubMed:24374177). Thought to act in autophagasome and omegasome formation (PubMed:20550938).
messages: Membrane
messages: Ubiquitously expressed during embrygogenesis.

6239:CELE T15D6.5
gene id: 6239:CELE_T15D6.5
uniprot id: Q9XU74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F59F3.5
gene id: 6239:CELE_F59F3.5
uniprot id: Q21041
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.

6239:CELE T08D2.7
gene id: 6239:CELE_T08D2.7
uniprot id: A4F324
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE K02B9.4
gene id: 6239:CELE_K02B9.4
uniprot id: E5QCG7
uniprot id: E5QCG8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F55F8.6
gene id: 6239:CELE_F55F8.6
uniprot id: P91344
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.

6239:CELE Y46H3A.3
gene id: 6239:CELE_Y46H3A.3
uniprot id: P06582
uniprot id: V6CLQ2
names: Induction
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Induced by white light exposure.

6239:CELE T01H8.5
gene id: 6239:CELE_T01H8.5
uniprot id: G5EGJ6
uniprot id: G5EGP7
uniprot id: Q93971
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily.
messages: Expressed both maternally and zygotically during embryonic development. Zygotic expression starts during early embryonic cleavage.
messages: Gonads.
messages: Membrane
messages: Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel.

6239:CELE T24H10.7
gene id: 6239:CELE_T24H10.7
uniprot id: G5ECU7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. Jun subfamily.
messages: Expressed in all cells of the developing spermatheca and in the spermatheca-uterine junction core cells at larval stage L4.
messages: Heterodimer; with fos-1.
messages: Isoform a, isoform b, isoform c and isoform d are expressed in the spermatheca (PubMed:19570917, PubMed:24178943).
messages: Nucleus
messages: Sixty percent of animals display an egg laying defective phenotype. Animals display numerous defects in the reproductive system and have a reduced brood size.
messages: Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3' (PubMed:17942488). Required for ovulation (PubMed:19570917). Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917).

6239:CELE Y97E10AL.2
gene id: 6239:CELE_Y97E10AL.2
uniprot id: Q965S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Membrane

6239:CELE R13A5.1
gene id: 6239:CELE_R13A5.1
uniprot id: D7UU24
uniprot id: H2KYJ9
uniprot id: H2KYK0
uniprot id: Q8T666
uniprot id: Q8WSP3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F07B7.9
gene id: 6239:CELE_F07B7.9
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE K06H6.3
gene id: 6239:CELE_K06H6.3
uniprot id: O17106
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R186.4
gene id: 6239:CELE_R186.4
uniprot id: G5EF06
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

6239:CELE C50F2.7
gene id: 6239:CELE_C50F2.7
uniprot id: P91181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

6239:CELE C29F7.3
gene id: 6239:CELE_C29F7.3
uniprot id: O17622
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
messages: Confers resistance to 5-fluorouracil.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and disassembling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis (By similarity).
messages: Cytoplasm
messages: Expressed in the hypodermis, intestine, and pharynx.
messages: Monomer.
messages: Nucleus

6239:CELE K07G5.6
gene id: 6239:CELE_K07G5.6
uniprot id: G5EBW5
names: Similarity
messages: Belongs to the ferrochelatase family.

6239:CELE C04G2.7
gene id: 6239:CELE_C04G2.7
uniprot id: G5ED14
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Expressed early in the larval L3 stage, in both P6.px daughters and all four P6.pxx granddaughters following the first and second divisions of the vulval precursor cells (VPCs) (PubMed:31398431). After final VPC divisions, expressed in vulF and vulE cells (derived from P6.p) and persists into mid-L4 larval stage (PubMed:31398431, PubMed:17020758). Expression in vulF and vulE diminishes during mid-L4 so that by the transition to late L4, only uterine ventral (uv1) cell expression remains (PubMed:31398431, PubMed:17020758). Expression in uvl continues through the adult molt into adulthood (PubMed:31398431).
messages: Nucleus
messages: Transcription factor (PubMed:17021039). Binds to specific DNA sequence motifs in regulatory elements, for example in the genes encoding transcription factor lin-48, apoptosis regulator ced-9 and neuropeptide-like protein nlp-2 (PubMed:17021039, PubMed:15923112, PubMed:11532910, PubMed:31398431). Specifies cell fate, playing an essential role in embryonic and larval development (PubMed:9374390, PubMed:10511553, PubMed:31398431, PubMed:17020758). Involved in morphogenesis of the vulva and uterus in hermaphrodites and of the rectal epithelium of the tail in males (PubMed:9374390, PubMed:15923112, PubMed:31398431, PubMed:17020758). Plays multiple roles in the development of the egg-laying system, acting in both lin-3/EGF-pathway-dependent and -independent processes (PubMed:31398431, PubMed:17020758). Positively regulates expression of neuropeptide-like proteins nlp-2 and nlp-7 in uvl cells in an EGF-pathway-dependent manner (PubMed:31398431). Involved in negatively modulating apoptosis in germline and somatic cells, acting in partial redundancy with transcription factor pax-2, probably by directly regulating transcription of ced-9 (PubMed:17021039). Positively regulates transcription of lin-48 in hindgut cells and functions in the development of the hindgut (PubMed:11532910, PubMed:15923112, PubMed:10511553).

6239:CELE F46E10.1
gene id: 6239:CELE_F46E10.1
uniprot id: Q5TKA4
uniprot id: Q9UAV8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE Y46G5A.10
gene id: 6239:CELE_Y46G5A.10
uniprot id: Q9U2D6
names: Developmental Stage
names: Disruption Phenotype
names: Subunit
names: Tissue Specificity
messages: Expressed from the gastrula stage throughout adulthood.
messages: Expressed in intestine.
messages: Interacts with tax-6.
messages: RNAi-mediated knockdown results in no obvious phenotype.

6239:CELE F47C10.8
gene id: 6239:CELE_F47C10.8
uniprot id: O01563
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y48B6A.13
gene id: 6239:CELE_Y48B6A.13
uniprot id: Q9U294
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

6239:CELE F09E5.3
gene id: 6239:CELE_F09E5.3
uniprot id: Q19264
names: Function
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.

6239:CELE Y71D11A.3
gene id: 6239:CELE_Y71D11A.3
uniprot id: Q8T8B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS).
messages: Monomer.

6239:CELE T07A9.11
gene id: 6239:CELE_T07A9.11
uniprot id: Q1XFY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

6239:CELE Y39G8B.10
gene id: 6239:CELE_Y39G8B.10
uniprot id: Q7YWR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K05C4.1
gene id: 6239:CELE_K05C4.1
uniprot id: Q9XUV0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins (PubMed:27528192). This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity).
messages: Cytoplasm
messages: No visible phenotype. Constitutive skn-1-dependent expression of the proteasomal subunit rpt-3. Double knockout with ddi-1, sel-1, sel-9, png-1 or skn-1a results in failed expression of the proteasomal subunit rpt-3.
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

6239:CELE Y53C12C.1
gene id: 6239:CELE_Y53C12C.1
uniprot id: O01996
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

6239:CELE E02H9.8
gene id: 6239:CELE_E02H9.8
uniprot id: A8WJ04
uniprot id: Q9TZ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C54E10.5
gene id: 6239:CELE_C54E10.5
uniprot id: O45315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE R13A5.5
gene id: 6239:CELE_R13A5.5
uniprot id: P17488
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C36C5.10
gene id: 6239:CELE_C36C5.10
uniprot id: O16403
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C12D8.11
gene id: 6239:CELE_C12D8.11
uniprot id: Q27274
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm
messages: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs.
messages: The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
messages: The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).

6239:CELE C06E2.3
gene id: 6239:CELE_C06E2.3
uniprot id: P52484
names: Function
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins.

6239:CELE Y71F9AM.5
gene id: 6239:CELE_Y71F9AM.5
uniprot id: G8JYG1
uniprot id: Q9U757
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus
messages: Preferentially binds Ran-GTP.
messages: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).

6239:CELE C34D4.2
gene id: 6239:CELE_C34D4.2
uniprot id: Q27475
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F32D1.10
gene id: 6239:CELE_F32D1.10
uniprot id: O16297
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

6239:CELE R09B3.5
gene id: 6239:CELE_R09B3.5
uniprot id: P49029
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the mago nashi family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (Probable). Positively regulates the nuclear export of spliced mRNAs including the sex determination gene tra-2 (PubMed:23149939). Promotes oogenesis and represses germline masculinization and spermatogenesis (PubMed:10656761, PubMed:14706697, PubMed:23149939). Required for embryonic development, possibly through positively regulating the expression of pie-1 (PubMed:30279189). Not required for the spatial patterning of pie-1 in embryos (PubMed:30279189).
messages: Expressed at all stages of development in hermaphrodites (PubMed:10656761). More abundant in embryos than in larvae and adults (PubMed:10656761). First expressed in embryos prior to morphogenesis, and after morphogenesis begins, primarily expressed in the head and tail regions (PubMed:10656761).
messages: Expressed in the soma and germline of hermaphrodites.
messages: Heterodimer with rnp-4/RBM8A (PubMed:14706697). Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, mag-1/MAGOH and rnp-4/RBM8A (Probable).
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic lethality due to developmental arrest during morphogenesis (PubMed:30279189). RNAi-mediated knockdown in the syncytial gonads of adult hermaphrodites results in some inviable embryos and then eventually no egg laying (PubMed:10656761). RNAi-mediated knockdown at the L1 larval stage results in the accumulation of unspliced mRNAs including ama-1 and ife-4 in the cytoplasm, and specifically in the production of an irregular unspliced form of the sex determining protein tra-2, which accumulates in the cytoplasm and inhibits the regular tra-2 isoforms a and c reducing their expression and disrupting their nuclear localization (PubMed:23149939). RNAi-mediated knockdown in L4 hermaphrodite larvae, results in no viable embryos and egg laying ceases due to masculinization of the germline (also called a mog phenotype) with animals producing undifferentiated germ cells and sperm instead of oocytes (PubMed:10656761, PubMed:14706697). In these animals, sperm are distributed throughout the germline, including the distal tip region (PubMed:10656761). RNAi-mediated knockdown does not result in masculinization of the germline in some animals, but these animals still do not produce oocytes with germlines appearing disorganized (PubMed:10656761). RNAi-mediated knockdown reduces the expression of pie-1 in P2 blastomeres (PubMed:30279189).

6239:CELE ZK652.6
gene id: 6239:CELE_ZK652.6
uniprot id: P34664
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C34C12.7
gene id: 6239:CELE_C34C12.7
uniprot id: Q09271
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C26C6.3
gene id: 6239:CELE_C26C6.3
uniprot id: Q18206
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in hypodermal cells. Also detected in the hypodermal seam cells in L4 larvae and young adults. In old adult hermaphrodites, it localizes to the vulva (at protein level).
messages: Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:15255192).
messages: Secreted
messages: Worms exhibit a trail of old cuticle that remains attached to the posterior part of the body.

6239:CELE K06B4.10
gene id: 6239:CELE_K06B4.10
uniprot id: O17934
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F38G1.2
gene id: 6239:CELE_F38G1.2
uniprot id: G5EEF1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

6239:CELE B0365.1
gene id: 6239:CELE_B0365.1
uniprot id: P90731
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

6239:CELE T07E3.6
gene id: 6239:CELE_T07E3.6
uniprot id: G8JYC6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Conditional knockdown in AVB, PVP, and SIAV neurons reduces exploratory roaming behavior.
messages: Expressed throughout postembryonic life (PubMed:19686386). Expressed in hermaphrodites in the interneurons ADAL/R and PVT, the chemosensory neuron pairs ASI, ASK, PHA and PHB, the RMED, RMEV and RID motor neurons, the sensory neuron pair ADE, the PQR mechanosensory neuron and in the PVPL/R interneurons (PubMed:19686386, PubMed:23764289). Also expressed in rectal gland cells rectD and rectVL/R, and the intestino-rectal valve cells virL/R (PubMed:19686386). Expressed in both sexes in the head interneurons SAAV, SAAD, SIAV, AVB, AIM, RMG, and in the tail in the interneurons PVN, LUA, PVT, and the pair PVS and PVU (referred to as PVP left and right in the hermaphrodite) (PubMed:23143519, PubMed:23764289, PubMed:23972393). Expressed in male-specific ventral cord neurons CP7 and CP8, and PDC (PubMed:23143519). Expression from the AIM interneurons in males is involved in mate searching behavior (PubMed:23143519).
messages: Probable ligand of isoforms a and b of the calcitonin receptor-like protein, pdfr-1, a G-protein coupled receptor (PubMed:18390545). May not signal through isoform c of pdfr-1 (PubMed:18390545). Involved in locomotion; more specifically mate searching behavior of males, independent of nutritional status (PubMed:18390545, PubMed:22579613, PubMed:23143519, PubMed:30024377). Involved in regulating the male-specific expression of TGFbeta-like daf-7 in the ASJ chemosensory neurons (PubMed:30024377). Plays a role in circadian rhythms of locomotor activity (PubMed:26113231). Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide flp-2 (PubMed:23764289, PubMed:27585848). In the presence of food, plays a role in initiating and extending exploratory roaming behavior, in opposition to 5-hydroxytryptamine (serotonin) signaling.
messages: Secreted

6239:CELE B0491.8
gene id: 6239:CELE_B0491.8
uniprot id: G5EEX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

6239:CELE ZK697.5
gene id: 6239:CELE_ZK697.5
uniprot id: O44573
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T13H5.4
gene id: 6239:CELE_T13H5.4
uniprot id: Q22469
names: Similarity
messages: Belongs to the SF3A3 family.

6239:CELE F56F10.1
gene id: 6239:CELE_F56F10.1
uniprot id: P90893
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE F11C1.4
gene id: 6239:CELE_F11C1.4
uniprot id: Q19347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

6239:CELE F54F3.4
gene id: 6239:CELE_F54F3.4
uniprot id: G5EGA6
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of isatin, 4-oxonon-2-enal, 9,10-phenanthrenequinone, menadione, 2,3-hexaenadione, 3,4-hexanedione and 2,3-heptanedione.

6239:CELE R04B3.2
gene id: 6239:CELE_R04B3.2
uniprot id: Q21697
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ntn-hydrolase family.
messages: Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity (By similarity).
messages: Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Lysosome

6239:CELE Y71G12B.8
gene id: 6239:CELE_Y71G12B.8
uniprot id: Q95XM9
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE R10D12.7
gene id: 6239:CELE_R10D12.7
uniprot id: Q9XVJ8
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE W03G9.10
gene id: 6239:CELE_W03G9.10
uniprot id: G4SFM0
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE F47G9.1
gene id: 6239:CELE_F47G9.1
uniprot id: Q20546
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6239:CELE W02G9.4
gene id: 6239:CELE_W02G9.4
uniprot id: A0A0M7RE06
uniprot id: O61901
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK484.2
gene id: 6239:CELE_ZK484.2
uniprot id: O44897
uniprot id: Q8IA64
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

6239:CELE F27D9.6
gene id: 6239:CELE_F27D9.6
uniprot id: Q19843
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y37E11AL.7
gene id: 6239:CELE_Y37E11AL.7
uniprot id: Q965Y1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

6239:CELE C08B11.6
gene id: 6239:CELE_C08B11.6
uniprot id: Q09443
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP6 subfamily.
messages: Expressed throughout development.
messages: cytoskeleton

6239:CELE ZK218.6
gene id: 6239:CELE_ZK218.6
uniprot id: O46003
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y49A3A.4
gene id: 6239:CELE_Y49A3A.4
uniprot id: Q9XW91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y40H7A.6
gene id: 6239:CELE_Y40H7A.6
uniprot id: Q9XW96
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H27D07.5
gene id: 6239:CELE_H27D07.5
uniprot id: O61912
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C24H11.8
gene id: 6239:CELE_C24H11.8
uniprot id: A1EHR5
uniprot id: Q9XVD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F34D10.5
gene id: 6239:CELE_F34D10.5
uniprot id: G5EDU6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Differences in the regulation of lin-48 expression may explain, at least in part, differences in excretory duct morphology and function between C.elegans and the related species C.briggsae.
messages: Expressed in late embryogenesis and into adulthood (PubMed:11532910, PubMed:16310763). Expression in the excretory duct cell begins in the majority of embryos by comma stage and persists throughout larval development into adulthood (PubMed:16310763). Expressed in L1 stage larvae in the excretory duct cell, neuronal support cells of the phasmid and labial sensory structures and a small number of additional unidentified cells in the head (PubMed:11532910, PubMed:12231624).
messages: Nucleus
messages: Transcription factor (By similarity). Involved in development of the hindgut, the male tail, and the excretory duct cell (PubMed:10511553, PubMed:11532910, PubMed:12231624). Involved in modulating function of excretory duct cells (PubMed:14758362). Plays a role in left/right patterning of cell fates in the hindgut (PubMed:10511553, PubMed:11532910).

6239:CELE C29E4.8
gene id: 6239:CELE_C29E4.8
uniprot id: P34346
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

6239:CELE F56B6.4
gene id: 6239:CELE_F56B6.4
uniprot id: H2KYQ5
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.
messages: Divalent metal ions. Required for self-glucosylation. Manganese is the most effective.
messages: Forms a heterooctamer with one molecule of gyg-1 bound to each protomer of the gys-1 homotetramer. The N-terminus of gys-1 is involved in interprotomer contacts with gyg-1. The interaction with gys-1 is required for glycogen production but is not required for gys-1 intrinsic activity.
messages: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for gsy-1.
messages: Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself, forming an alpha-1,4-glycan of around 10 residues attached to Tyr-194.
messages: The length of the linker region between residues 387-394 which separates two alpha-helices regulates the size of the glycogen particles synthesized but plays no role in the interaction with gsy-1.

6239:CELE C33G8.8
gene id: 6239:CELE_C33G8.8
uniprot id: Q18393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F38A5.22
gene id: 6239:CELE_F38A5.22
uniprot id: V6CLT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE R10E11.1
gene id: 6239:CELE_R10E11.1
uniprot id: P34545
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Acetyltransferase enzyme (By similarity). Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535). In differentiated cells, negatively regulates localization of heterochromatin to the nuclear periphery (PubMed:31118512). Plays a role in migration of gonadal distal tip cells, where it probably modulates expression of genes involved in integrin-mediated adhesion (PubMed:24811939).
messages: Expressed in the gonadal distal tip cells (DTC) during larval stages L2, L3 and L4.
messages: Interacts (via N-terminus domain and HAT domain) with prmt-5; the interaction results in methylation of cbp-1 (PubMed:19521535). Interacts (via HAT domain) with cep-1; cep-1 transcriptional activity may be inhibited by interaction with methylated cbp-1 (PubMed:19521535). Component of a complex that contains prmt-5 and cbp-1 (PubMed:19521535).
messages: Methylation by prmt-5 may repress the capacity of cbp-1 to enhance cep-1-dependent transcription of egl-1.
messages: Nucleus
messages: RNAi-mediated knockdown targeted to the gonadal distal tip cells (DTC) causes DTC migration defects (PubMed:24811939). Significant reduction in expression of src-1, tln-1 and nmy-2 in DTCs (PubMed:24811939). RNAi-mediated knockdown on an mrg-1;cec-4 double mutant background restores positioning of heterochromatin to the nuclear periphery (PubMed:31118512).

6239:CELE T21B4.4
gene id: 6239:CELE_T21B4.4
uniprot id: Q1ZXT1
uniprot id: Q1ZXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

6239:CELE Y49E10.14
gene id: 6239:CELE_Y49E10.14
uniprot id: Q94131
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Disrupts blastomere cell fate. Excessive pharyngeal cells produced during embryogenesis. Reduced expression of nos-2 in P4 germline blastomeres and absence of nos-2 protein.
messages: Expressed in 1, 2 and 4-cell embryos (at protein level) (PubMed:10983990, PubMed:30279189). Expression increases between P0 (the zygote) and P2 blastomeres due to its asymmetric segregation in P1 and P2 blastomeres, its degradation in somatic cells and its translation in the P lineage (at protein level) (PubMed:30279189).
messages: Interacts with hda-1, let-418 and mep-1. Interacts (via C terminus) with cit-1.1 (via C terminus).
messages: Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex.
messages: Nucleus
messages: The C3H1-type 1 domain is required for degradation in somatic blastomeres.
messages: The C3H1-type 2 domain targets the protein to P granules, is involved in germ cell positioning in embryos and is required for default nos-2 expression.
messages: centrosome
messages: spindle

6239:CELE F29B9.4
gene id: 6239:CELE_F29B9.4
uniprot id: Q9GYI4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the JMJD6 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase.
messages: Interacts with ced-5 and ced-12.
messages: Nucleus
messages: Was initially thought to constitute the phosphatidylserine receptor, a receptor that mediates recognition of phosphatidylserine, a specific marker only present at the surface of apoptotic cells, and participates in apoptotic cell phagocytosis. However, some results strongly suggest that it does not constitute the receptor for phosphatidylserine and is not involved in apoptotic cell removal.
messages: Worms lacking psr-1 display more cell corpses than in wild-type animals.

6239:CELE M162.5
gene id: 6239:CELE_M162.5
uniprot id: Q9U3A4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T02E1.7
gene id: 6239:CELE_T02E1.7
uniprot id: O45731
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

6239:CELE Y17G7B.15
gene id: 6239:CELE_Y17G7B.15
uniprot id: Q9XXH8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Causes a delay in cell death during embryogenesis characterized by a decrease in the number of cell corpses at the comma and 1,5 fold stage and an increase in the number of cell corpses between the 2-fold and the 3-fold stages.
messages: Cell membrane
messages: Cleaved by caspase ced-3 after Asp-382 and Asp-609. Cleavage at Asp-382 is required for subsequent cleavage at Asp-609.
messages: Cytoplasm
messages: Expressed in embryos.
messages: GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6 (PubMed:22869721).
messages: Interacts (via C-terminal ankyrin repeat) with rab-10 (GTP-bound form); the interaction is required for cnt-1 recruitment to endosomes. Interacts (via C-terminal ankyrin repeat) with rab-8 (GTP-bound form) and rab-35 (GTP-bound form).
messages: Recycling endosome membrane
messages: The PH domain binds phosphatidylinositol phosphate (PIP), phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), and to a lesser extent phosphatidic acid and cardiolipin.
messages: Truncated cnt-1: Promotes apoptosis during embryonic development. Produced by caspase ced-3-mediated cleavage, and translocates to the plasma membrane where it prevents the activation of the prosurvival Akt-1/2 and sgk-1 signaling pathway by competing with Akt-1/2 for the binding to PtdIns(3,4,5)P3.

6239:CELE C07D10.4
gene id: 6239:CELE_C07D10.4
uniprot id: P55113
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in the head of adult hermaphrodites but not within pharynx cells (PubMed:14653817). Expressed in pharyngeal muscles, mc cells, intestine, hypodermal seam cells, arcade cells, spermatheca, vulva and rectal epithelial cells (PubMed:20109220).
messages: In the embryo, expression is detected just before hatching.
messages: Metalloprotease.
messages: No visible phenotype. In a nas-6 (hd108) mutant background, enhances slow growth of nas-6 single mutant.
messages: Secreted

6239:CELE K10C3.4
gene id: 6239:CELE_K10C3.4
uniprot id: O45665
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Membrane
messages: extracellular exosome

6239:CELE F20D1.1
gene id: 6239:CELE_F20D1.1
uniprot id: Q93533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane
messages: synaptic vesicle membrane

6239:CELE T22E5.2
gene id: 6239:CELE_T22E5.2
uniprot id: Q22682
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
messages: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport.

6239:CELE F38A6.3
gene id: 6239:CELE_F38A6.3
uniprot id: G5EGD2
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 66% do not survive embryogenesis when cultured in hypoxic conditions of 1% oxygen. Able to survive anoxic conditions (PubMed:11427734, PubMed:12006646). Inefficient translocation of aha-1 to the nucleus (PubMed:11427734). Inability to acclimate to heat (PubMed:12686697). Partial resistance to paralysis and killing by enteropathogenic E.coli and P.aeruginosa (PubMed:16091039, PubMed:20865124). Extends lifespan in a temperature dependent manner but not when grown with a restricted diet (PubMed:19461873, PubMed:21093262). At lower temperatures impairs lifespan because of a vulval integrity defect (PubMed:21241450). Unable to survive in even relatively low concentrations of hydrogen sulfide (PubMed:19889840). Reduced body levels of Mn(2+) and iron (PubMed:22194696). In low iron conditions, only 20% of animals reach the L4 larval stage (PubMed:22194696). RNAi-mediated knockdown causes an increase in ftn-1 and ftn-2 mRNA levels in normal conditions and prevents the repression of smf-3, ftn-1 and to a lesser extent ftn-2 mRNA transcription in response to low iron levels (PubMed:22194696).
messages: A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959). Involved in mediating susceptibility to enteropathogenic E.coli (PubMed:16091039). Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureus infection (PubMed:20865124, PubMed:22792069). Required for aha-1 nuclear localization (PubMed:11427734). Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959). Role in life span extension is dependent of temperature (PubMed:21241450). Not required for survival in anoxic conditions (PubMed:11427734). Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696). May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696).
messages: Binds to aha-1 (PubMed:11427734). Interacts (hydroxylated on Pro-621) with vhl-1; the interaction induces hif-1 degradation (PubMed:11595184).
messages: By heat acclimation, hypoxia and addition of 50 ppm hydrogen sulfide (PubMed:11427734, PubMed:12686697, PubMed:19889840). By low iron levels (PubMed:22194696).
messages: Expressed in all somatic cells.
messages: Hydroxylation on Pro-621 by egl-9 during normoxia conditions is required for vhl-1-mediated proteasomal degradation.
messages: Nucleus

6239:CELE Y47D3B.11
gene id: 6239:CELE_Y47D3B.11
uniprot id: Q9U2B7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autoubiquitinated.
messages: Belongs to the ZNRF3 family.
messages: Cell membrane
messages: Early endosome
messages: Expressed in a subset of head, ventral nerve cord and tail neurons, the excretory canal and tail epidermis.
messages: First expressed during the late gastrulation stage of embryogenesis with high expression in the tail region (PubMed:25448694). In the comma stage of embryogenesis, expression is prominent in the body wall muscle cells (PubMed:25448694). In early larval development, expressed in hypodermal cells, muscle, the pharynx, intestine and in anal depressor and stomatointestinal muscle (PubMed:25448694). In the nervous system, transiently expressed in late embryogenesis and early larval development in AVG unpaired interneurons and during larval development, expressed in neurons in the head and tail ganglia and ventral cord motor neurons (PubMed:24401370, PubMed:25448694). In the late stages of larval development, expressed in the distal tip cell, the vulva, uterine muscle cells and the VC4 and VC5 neurons that flank the vulva (PubMed:25448694).
messages: Late endosome
messages: Mutants exhibit cell migration and axon guidance defects in HSN, AVK, CAN and AVG neurons, and also display excretory canal elongation defects with premature termination of the canal. Double knockout with either unc-53 or vab-8 results in premature termination of the AVG axon and AVG polarity defects.
messages: Perikaryon
messages: Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694). Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370). May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694).
messages: The RING finger region is required to block Wnt signaling and is also required for endosomal localization.
messages: axon

6239:CELE C09B8.4
gene id: 6239:CELE_C09B8.4
uniprot id: Q17846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

6239:CELE R09B3.1
gene id: 6239:CELE_R09B3.1
uniprot id: G5EBR7
uniprot id: Q564V5
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

6239:CELE Y40B10A.7
gene id: 6239:CELE_Y40B10A.7
uniprot id: Q8WTM3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6239:CELE C54A12.2
gene id: 6239:CELE_C54A12.2
uniprot id: A0A131MBD2
uniprot id: A0A131MC86
uniprot id: A0A131MCZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE Y77E11A.1
gene id: 6239:CELE_Y77E11A.1
uniprot id: Q9N4A5
uniprot id: U4PBN7
uniprot id: U4PC09
names: Similarity
messages: Belongs to the hexokinase family.

6239:CELE C54G4.4
gene id: 6239:CELE_C54G4.4
uniprot id: Q18849
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y43F4B.4
gene id: 6239:CELE_Y43F4B.4
uniprot id: O45933
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the nuclear pore complex (NPC). Probably part of the GATOR complex.
messages: Lysosome membrane
messages: No visible phenotype.
messages: Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.
messages: nuclear pore complex

6239:CELE F21G4.1
gene id: 6239:CELE_F21G4.1
uniprot id: Q93550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane

6239:CELE B0432.8
gene id: 6239:CELE_B0432.8
uniprot id: P90989
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

6239:CELE T07H6.2
gene id: 6239:CELE_T07H6.2
uniprot id: Q22329
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Porcupine subfamily.
messages: Embryonic lethal with severely defective embryonic morphogenesis with no endoderm and excess mesoderm. In addition, embryos have defective mitotic spindle orientation in the 8-cell stage ABar blastomere.
messages: Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins (PubMed:10444600, PubMed:15020416, PubMed:9288750). Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins (By similarity). Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling (PubMed:10444600, PubMed:15020416, PubMed:9288750). Involved in cytosketetal polarity (PubMed:10444600, PubMed:15020416, PubMed:9288750). Required for the orientation of mitotic spindle axis (PubMed:9288749, PubMed:10444600, PubMed:15020416, PubMed:9288750).
messages: Membrane

6239:CELE Y71H2AM.23
gene id: 6239:CELE_Y71H2AM.23
uniprot id: G5ECM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm

6239:CELE K06C4.11
gene id: 6239:CELE_K06C4.11
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE K07A12.7
gene id: 6239:CELE_K07A12.7
uniprot id: Q9NAP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE T08B1.6
gene id: 6239:CELE_T08B1.6
uniprot id: O44560
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

6239:CELE T28F2.3
gene id: 6239:CELE_T28F2.3
uniprot id: O02637
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Membrane
messages: Reversible hydration of carbon dioxide.

6239:CELE ZK858.7
gene id: 6239:CELE_ZK858.7
uniprot id: Q94416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

6239:CELE F33D11.12
gene id: 6239:CELE_F33D11.12
uniprot id: Q95X59
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F46B3.1
gene id: 6239:CELE_F46B3.1
uniprot id: Q9XV17
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R04D3.8
gene id: 6239:CELE_R04D3.8
uniprot id: Q21716
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE M163.3
gene id: 6239:CELE_M163.3
uniprot id: P10771
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Cytoplasm
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures (Probable) (PubMed:23028351). Probably does not act as global transcriptional repressor (PubMed:23028351). Acting in concert with chromobox protein homologs hpl-1 and hpl-2, involved in reproduction, somatic gonad development, male tail development, and vulval cell fate decisions; perhaps as a result of modulating expression of Hox genes mab-5 and egl-5 (PubMed:23028351). Plays a role in linking epigenetic regulation with the innate immune response (PubMed:22083954).
messages: Interacts with nmad-1 (PubMed:31283754). Interacts (when monomethylated at Lys-14) with chromobox protein homolog hpl-1; the interaction is direct (PubMed:23028351). Interacts (when monomethylated at Lys-14) with histone H3 (when trimethylated on 'Lys-27'); the interaction is direct (PubMed:23028351).
messages: Methylation at lysine 14 is necessary to regulate male tail development.
messages: Nucleus

6239:CELE C54G4.1
gene id: 6239:CELE_C54G4.1
uniprot id: Q18846
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Activated by multiple phosphorylations on threonine and serine residues.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Enzyme activity requires the presence of both kinase domains.
messages: Serine/threonine kinase that may play a role in mediating the mitogen- and stress-induced effects on transcription. May repress transcription via phosphorylation of 'Ser-1' of histone H2A. May phosphorylate histone H3 (By similarity).

6239:CELE C54H2.5
gene id: 6239:CELE_C54H2.5
uniprot id: Q18864
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum cargo receptor that mediates the export of the yolk proteins from intestinal cells by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117). Required for the endoplasmic reticulum export of the yolk protein vit-2, which is synthesized as a lipoprotein complex, from intestinal cells (PubMed:29643117). Involved in endoplasmic reticulum exit sites (ERES) organization (PubMed:29643117).
messages: Endoplasmic reticulum membrane
messages: High rate of embryonic and larval lethality (PubMed:29643117). Some mutants reach adulthood but display severe accumulation of vit-2 in large granule-like structures in intestinal cells (PubMed:29643117).
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

6239:CELE T04A11.3
gene id: 6239:CELE_T04A11.3
uniprot id: O18016
names: Subcellular Location Annotation
messages: Cell membrane

6239:CELE F14F7.1
gene id: 6239:CELE_F14F7.1
uniprot id: O17805
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE E01A2.3
gene id: 6239:CELE_E01A2.3
uniprot id: Q27886
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Wnt family.
messages: Cell fate decisions disrupted, protein localization altered and neuron translocation disrupted. Defective tail development in males. Defective in egg laying in hermaphrodites. Nuclear localization of wrm-1 and lit-1 appears disrupted. Similar to tau-induced unc phenotype. Deviations in vulval precursor cell fate are observed when knocked down in conjunction with cwn-1 and egl-20. Bivulval phenotype when accompanied by mom-2 and/or cwn-2 knockdowns. Increase in ectopic synaptic vesicle puncta.
messages: Expressed during embryogenesis and larval development (PubMed:17719547, PubMed:7553861, PubMed:8026318). Mainly expressed in the tail during larval stages (PubMed:20711352).
messages: Expressed in the tail hypodermis.
messages: Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 localization in axon development and positioning of neuromuscular synapses in DA9 regions by negatively regulating synaptogenesis. Plays a role in motorneuron development by promoting the extension of the anterior neurite of ventral D-type GABAergic motorneurons along the anterior-posterior axis of the ventral nerve cord (PubMed:23376536).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE F08G5.4
gene id: 6239:CELE_F08G5.4
uniprot id: Q19218
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F32D1.1
gene id: 6239:CELE_F32D1.1
uniprot id: A0A168H4I0
uniprot id: O16299
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the AAA ATPase family.
messages: Expressed in germ cells.
messages: Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility.
messages: Hexamer.
messages: Nucleus
messages: Sterility owing to depletion of germ cells.

6239:CELE C54F6.13
gene id: 6239:CELE_C54F6.13
uniprot id: O16452
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endomembrane system
messages: Expressed in hypodermal cells of the main body syncytium, ut1 cells of the vulva and the spermathecal junction cell.
messages: Phosphorylated.
messages: Plays a role in epithelial membrane transport processes.

6239:CELE K01A11.4
gene id: 6239:CELE_K01A11.4
uniprot id: G3MTY7
uniprot id: G5EF09
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y39B6A.19
gene id: 6239:CELE_Y39B6A.19
uniprot id: B2FDA9
uniprot id: Q9NEV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE AC3.8
gene id: 6239:CELE_AC3.8
uniprot id: Q17404
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F15A4.3
gene id: 6239:CELE_F15A4.3
uniprot id: O17818
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F32H2.2
gene id: 6239:CELE_F32H2.2
uniprot id: P91869
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE C10H11.9
gene id: 6239:CELE_C10H11.9
uniprot id: P92199
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by rho-1 binding.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cleavage furrow
messages: Cytoplasm
messages: Expressed in the lateral hypodermal seam cells at the onset of the elongation phase of morphogenesis (at protein level).
messages: Interacts with rho-1.
messages: Loss of both zygotic and maternal expression causes defects in embryonic elongation and P-cell migration, loss of only maternal expression results in abnormal early cleavages, loss of only zygotic expression results in sterility.
messages: Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.
messages: cytoskeleton

6239:CELE W06G6.8
gene id: 6239:CELE_W06G6.8
uniprot id: Q9XU59
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F32G8.5
gene id: 6239:CELE_F32G8.5
uniprot id: Q19979
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T21B10.2
gene id: 6239:CELE_T21B10.2
uniprot id: Q27527
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

6239:CELE C04H5.6
gene id: 6239:CELE_C04H5.6
uniprot id: O45244
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.
messages: Embryonic lethal. Defects in oocytogenesis and spermatogenesis. Approximately 80% of mutants have an abnormal somatic gonad and no vulva.
messages: Expressed throughout development but most strongly in embryos and the L4 larvae stage.
messages: Interacts with mep-1 and smn-1.
messages: Nucleus

6239:CELE F59D6.3
gene id: 6239:CELE_F59D6.3
uniprot id: O16338
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C48E7.11
gene id: 6239:CELE_C48E7.11
uniprot id: Q8IG69
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Expressed broadly in somatic tissues including the intestine.
messages: Interacts with transcription factor zip-11.
messages: Nucleus
messages: RNAi-mediated knockdown reduces overall fat content (PubMed:26505800). Decreases survival upon infection with P.aeruginosa (PubMed:26876169, PubMed:28662060). Reduces induction of expression of infection response gene, irg-1, in response to P.aeruginosa (PubMed:26876169). The decrease in survival upon P.aeruginosa infection on a zip-11 mutant background is abolished by RNAi-mediated knockdown of cebp-2.
messages: Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Regulates expression of genes involved in fat metabolism, including ech-1.1 and fat-5 (PubMed:26505800). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:26876169, PubMed:28662060, PubMed:34804026). Required for the activation of infection response gene irg-1 following P.aeruginosa infection (PubMed:26876169). Required to prevent P.aeruginosa ToxA-mediated lethality (PubMed:26876169). May also function in concert with transcription factor zip-11 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway (PubMed:34804026). May act together with the bZIP transcription factor, zip-2 (PubMed:26876169).

6239:CELE R09B5.4
gene id: 6239:CELE_R09B5.4
uniprot id: O44607
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

6239:CELE C01G6.7
gene id: 6239:CELE_C01G6.7
uniprot id: Q17577
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Expressed in intestine.
messages: Peroxisome
messages: Plays a role in ascaroside pheromones biosynthesis, which regulates development and behavior (PubMed:29863473, PubMed:28371259, PubMed:32702987). Specifically, activates the side chain of medium-chain indol-3-carbonyl (IC)-ascarosides for shortening through beta-oxidation (PubMed:29863473, PubMed:32702987). Converts IC-asc-C7 and IC-asc-C9 into IC-asc-C7-CoA and IC-asc-C9-CoA, respectively (PubMed:29863473, PubMed:32702987). May play a role in fatty-acid metabolism by activating and converting nonanoate (C9) into nonanoyl-CoA (C9-CoA) (PubMed:29863473).

6239:CELE C25H3.14
gene id: 6239:CELE_C25H3.14
uniprot id: Q8IG45
names: Similarity
messages: Belongs to the thioesterase PaaI family.

6239:CELE T28F2.4
gene id: 6239:CELE_T28F2.4
uniprot id: O01658
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Attenuated response to heat shock stress and reduced survival after heat shock and oxidative stress.
messages: Belongs to the ROX family. NO66 subfamily.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Nucleus
messages: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress.

6239:CELE T04C10.1
gene id: 6239:CELE_T04C10.1
uniprot id: Q8WQL7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Expressed in all somatic cells.
messages: First observed during early cell morphogenesis in the embryo, levels increase during later embryonic development and remain at comparable levels throughout larval and adult stages.
messages: No visible phenotype.
messages: Nucleus
messages: Possible role in the function of olfactory neurons.

6239:CELE F40F9.7
gene id: 6239:CELE_F40F9.7
uniprot id: Q20237
uniprot id: Q86G95
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C01C10.3
gene id: 6239:CELE_C01C10.3
uniprot id: Q11087
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: Membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

6239:CELE K10H10.2
gene id: 6239:CELE_K10H10.2
uniprot id: O45679
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: By hydrogen sulfide or cyanide (PubMed:21840852). By morpholin-4-ium 4-methoxyphenyl (morpholino) phosphinodithioate (GYY4137) (PubMed:24260346).
messages: Homodimer.
messages: Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O-acetylserine and hydrogen sulfide (PubMed:24100226). By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection (PubMed:21840852). Involved in fertility, growth and aging (PubMed:24260346). Does not mediate survival in high levels of hydrogen sulfide (PubMed:21840852).

6239:CELE Y119D3B.16
gene id: 6239:CELE_Y119D3B.16
uniprot id: Q95Y71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL45 family.
messages: Mitochondrion

6239:CELE C33H5.14
gene id: 6239:CELE_C33H5.14
uniprot id: Q18411
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Golgi apparatus membrane
messages: In contrast to uda-1, expression is not induced by stress.
messages: Seems to be able to hydrolyze CTP, ATP and UTP.

6239:CELE F58H1.1
gene id: 6239:CELE_F58H1.1
uniprot id: Q2PJ74
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE T04F8.2
gene id: 6239:CELE_T04F8.2
uniprot id: Q22162
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W04A4.3
gene id: 6239:CELE_W04A4.3
uniprot id: O45889
names: Similarity
messages: Belongs to the GILT family.

6239:CELE M03C11.8
gene id: 6239:CELE_M03C11.8
uniprot id: G5EDG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).
messages: Nucleus

6239:CELE Y59E9AR.7
gene id: 6239:CELE_Y59E9AR.7
uniprot id: G5EBJ8
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE K03H1.1
gene id: 6239:CELE_K03H1.1
uniprot id: P34497
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Homooctamer.

6239:CELE F27C8.1
gene id: 6239:CELE_F27C8.1
uniprot id: Q19834
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C44B12.2
gene id: 6239:CELE_C44B12.2
uniprot id: P34714
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SPARC family.
messages: Expressed by body wall and sex muscle cells. Probable association with basement membranes.
messages: First expressed in unhatched larvae; continuous throughout subsequent larval stages and in adults.
messages: Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis.
messages: basement membrane

6239:CELE C24G6.4
gene id: 6239:CELE_C24G6.4
uniprot id: Q17370
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F16H11.3
gene id: 6239:CELE_F16H11.3
uniprot id: Q19495
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE F54A5.1
gene id: 6239:CELE_F54A5.1
uniprot id: Q9TYT0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HMBOX1 homeobox family.
messages: Expressed in both AWC neurons (PubMed:20713521). Also expressed in the FLP mechanosensory neurons (PubMed:20713521).
messages: Nucleus
messages: RNAi-mediated knockdown has little effect on srsx-3 expression in the AWC neuron.
messages: Transcriptional repressor which maintains cell fate asymmetry of AWC neurons in adults by repressing the expression of multiple AWC (OFF) genes, including srsx-3 in the AWC (ON) neuron.

6239:CELE F11A1.3
gene id: 6239:CELE_F11A1.3
uniprot id: G5EFF5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed throughout muscles of the pharynx (PubMed:11072073). Expressed in epidermal seam cells, the vulva, head neurons, mature spermatheca, uterus and intestine (PubMed:10859169, PubMed:23990780).
messages: Interacts with din-1 isoform d.
messages: Nuclear receptor which binds directly to response elements in target gene promoters (PubMed:9477318, PubMed:10859169, PubMed:15314028, PubMed:15489294, PubMed:15383841, PubMed:15611047, PubMed:16626392, PubMed:19828440, PubMed:21814518). Activity is modulated by binding of steroid hormone ligands that include dafachronic acids (PubMed:16529801). Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues (PubMed:9477318, PubMed:10859169, PubMed:15489294, PubMed:15383841, PubMed:16626392, PubMed:19828440, PubMed:21814518). Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1 (PubMed:19828440). Plays a role in controlling the timing of seam cell development during the larval stages (PubMed:21471153). Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs (PubMed:23990780). Controls expression of genes that promote the aerobic catabolism of fatty acids for reproductive growth (PubMed:25774872). May be involved in thermotolerance (PubMed:24957743).
messages: Nucleus
messages: Produced by alternative initiation at Met-487 of isoform a.
messages: Produced by alternative initiation at Met-60 of isoform a.
messages: Produced by alternative splicing.
messages: Reduced lifespan associated with accelerated aging and increased tissue deterioration (PubMed:16626392). Defective dauer formation (PubMed:9477318, PubMed:10859169). In the absence of cholesterol, arrest with abnormal cuticle formation (PubMed:15383841). Increased resistance to P.aeruginosa infection possibly due to elevated expression of antimicrobial genes (PubMed:23990780). Prevents increase in the number of muscle arm extension in a daf-2 (e1375) background (PubMed:18436204). RNAi-mediated knockdown results in reduced lifespan, but increased resistance to bacterial infection (PubMed:23990780).
messages: Widely expressed from embryo through to adult stages; peak expression levels seem to occur during larval stage L2.

6239:CELE K06A5.6
gene id: 6239:CELE_K06A5.6
uniprot id: O44549
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE ZK177.2
gene id: 6239:CELE_ZK177.2
uniprot id: Q09371
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C45G9.7
gene id: 6239:CELE_C45G9.7
uniprot id: Q09506
names: Function
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.

6239:CELE R11G11.5
gene id: 6239:CELE_R11G11.5
uniprot id: O16957
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK470.1
gene id: 6239:CELE_ZK470.1
uniprot id: Q23508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

6239:CELE T06E6.2
gene id: 6239:CELE_T06E6.2
uniprot id: Q10654
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II (PubMed:20599902).
messages: Nucleus
messages: RNAi-mediated knockdown causes a longer meiosis II in 1-cell embryos without affecting meiotic exit timing. In a pam-1 (or282) mutant background, restores normal timing for meiotic exit.

6239:CELE B0348.1
gene id: 6239:CELE_B0348.1
uniprot id: O61959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE T19H12.1
gene id: 6239:CELE_T19H12.1
uniprot id: H2KZ88
uniprot id: O01617
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48B6A.5
gene id: 6239:CELE_Y48B6A.5
uniprot id: Q9U2A7
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE K08C7.5
gene id: 6239:CELE_K08C7.5
uniprot id: G5EBJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

6239:CELE F46C8.6
gene id: 6239:CELE_F46C8.6
uniprot id: P34688
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.

6239:CELE ZC416.4
gene id: 6239:CELE_ZC416.4
uniprot id: H2KZI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

6239:CELE ZK430.3
gene id: 6239:CELE_ZK430.3
uniprot id: Q27538
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

6239:CELE T25B9.5
gene id: 6239:CELE_T25B9.5
uniprot id: A0A061ADQ6
uniprot id: Q22766
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE ZC123.4
gene id: 6239:CELE_ZC123.4
uniprot id: H2L0S7
uniprot id: Q65CM2
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE R11G10.3
gene id: 6239:CELE_R11G10.3
uniprot id: G5EEI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F15A2.3
gene id: 6239:CELE_F15A2.3
uniprot id: Q19473
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C16C10.4
gene id: 6239:CELE_C16C10.4
uniprot id: Q09250
names: Function
names: Similarity
names: Subunit
messages: Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity).
messages: Belongs to the SAP18 family.
messages: Interacts with SIN3 and histone deacetylase.

6239:CELE F19C6.5
gene id: 6239:CELE_F19C6.5
uniprot id: Q09308
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C35A5.8
gene id: 6239:CELE_C35A5.8
uniprot id: Q18476
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

6239:CELE F43D9.2
gene id: 6239:CELE_F43D9.2
uniprot id: Q20365
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane

6239:CELE T05G5.3
gene id: 6239:CELE_T05G5.3
uniprot id: P34556
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.
messages: Nucleus
messages: Phosphorylation both activates and inactivates the enzyme depending on the site of phosphorylation.
messages: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
messages: centrosome

6239:CELE F10E7.7
gene id: 6239:CELE_F10E7.7
uniprot id: P49180
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

6239:CELE W02B3.2
gene id: 6239:CELE_W02B3.2
uniprot id: Q09639
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
messages: Defective egg-laying with mutants retaining 35 eggs compared to 13-14 eggs in wild-type worms (PubMed:28213524, PubMed:28968387). Reduced serotonin levels, increased levels of the serotonin metabolite 5-hydroxyindoleacetic acid, increased levels of amine oxidase amx-2 in early adult stages and reduced levels of phosphorylated amx-2 (PubMed:28213524). Defective locomotion and reduced body length (PubMed:28968387).
messages: Expressed in many neurons in the adult including the ASH neurons and other sensory neurons, many interneurons, and motor neurons of the ventral nerve cord (PubMed:15157420). Expressed broadly in head neurons and is detected in several head acetylcholine neurons including the AVA, AVB, AVD and AVE premotor interneurons, the SMD and RMD head motor neurons, and the AIN, AIY, SIA, SIB and SAA interneurons (PubMed:28968387). Expressed in HSN motor neurons and VC4/VC5 motor neurons (PubMed:28213524). Also expressed in vulval muscle cells (PubMed:15157420, PubMed:28213524).
messages: Expression is observed in embryos as early as the 20-30 cell stage and persists throughout development and into adulthood.
messages: Interacts with amx-2; the interaction promotes phosphorylation of amx-2.
messages: Specifically phosphorylates the activated forms of G protein-coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis (PubMed:15157420). Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations (PubMed:16407969). Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin (PubMed:28213524). Acts in head acetylcholine neurons to positively regulate locomotion (PubMed:28968387). Inactivates dopamine receptor dop-3 which leads to inactivation of guanine nucleotide-binding protein G(o) subunit goa-1 and activation of the unc-77/nca-1 and nca-2 ion channel proteins (PubMed:28968387).
messages: The kinase domain is required for chemotaxis activity.

6239:CELE F39B2.2
gene id: 6239:CELE_F39B2.2
uniprot id: O45495
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Expressed from embryo to adulthood.
messages: Expressed in the pharynx, body wall muscle cells, vulval epithelia, distal tip cell, intestine, tail, head neurons and ventral cord motorneurons.
messages: Has no ubiquitin ligase activity on its own; may require ubiquitin-conjugating enzyme, ubc-13.
messages: Heterodimer with ubc-13.
messages: Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own (PubMed:15530417). The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63 (PubMed:15530417, PubMed:24595290). Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies (PubMed:24595290). Required for glr-1-containing glutamate receptor trafficking in neurons (PubMed:21179194). May have a role in synaptic transmission at motorneurons (PubMed:21179194). May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates (PubMed:17663792, PubMed:22494772).
messages: Nucleus
messages: Perikaryon
messages: Temperature sensitive with partial embryonic lethality at 25 degrees Celsius (PubMed:24595290). Inhibited degradation of maternal membrane proteins, cav-1, chs-1 and rme-2, and ubiquitination of cav-1 with accumulation of these proteins on the maternal plasma membrane and endosome-like vesicles in later-stage embryos (PubMed:24595290). Locomotion defect with animals displaying increased body flexing (PubMed:21179194). Mis-localized glr-1-containing glutamate receptor with increased glr-1 accumulation in the ventral nerve cord (PubMed:21179194). Reduced and irregular snb-1 accumulation at neuromuscular junctions (PubMed:21179194). RNAi-mediated knockdown prevents localization of ubiquitin and proteasomes to polyglutamine protein aggregates (PubMed:17663792). Reduced size of polyglutamine protein aggregates (PubMed:17663792). Inhibited degradation of the maternal membrane protein, cav-1 in embryos (PubMed:24595290).
messages: cytosol
messages: dendrite

6239:CELE C39H7.7
gene id: 6239:CELE_C39H7.7
uniprot id: Q95ZX2
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y41D4B.8
gene id: 6239:CELE_Y41D4B.8
uniprot id: Q95Y07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE K06C4.4
gene id: 6239:CELE_K06C4.4
uniprot id: Q27894
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE W07E6.2
gene id: 6239:CELE_W07E6.2
uniprot id: Q9TYV3
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE F07D10.1
gene id: 6239:CELE_F07D10.1
uniprot id: Q19162
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown results in a growth defect.
messages: There's a functional difference between the two L11-encoding proteins in C.elegans. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function.

6239:CELE C44C3.11
gene id: 6239:CELE_C44C3.11
uniprot id: Q7YXG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F26D12.1
gene id: 6239:CELE_F26D12.1
uniprot id: Q86ME9
uniprot id: Q86MF0
uniprot id: V6CIY1
uniprot id: V6CJE7
uniprot id: V6CKK8
uniprot id: V6CLC1
uniprot id: V6CLF5
uniprot id: V6CLS2
uniprot id: V6CLW4
uniprot id: V6CLX2
uniprot id: V6CLX8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0564.4
gene id: 6239:CELE_B0564.4
uniprot id: Q17529
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE F38E1.9
gene id: 6239:CELE_F38E1.9
uniprot id: Q20157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

6239:CELE Y38C1AB.5
gene id: 6239:CELE_Y38C1AB.5
uniprot id: G5ECT3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C13A2.1
gene id: 6239:CELE_C13A2.1
uniprot id: O16878
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE W01B6.1
gene id: 6239:CELE_W01B6.1
uniprot id: P34889
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Anterior displacement of the nerve ring in L1 stage mutant animals (PubMed:19855022). Defective ALM, BDU, CAN and QR neuroblast migration and irregular CP and CAN axon growth and guidance (PubMed:16109397). Double knockout with cfz-2 results in enhanced CAN migration defects, but the same QR neuroblast migration defects as the single cfz-2 knockout alone (PubMed:16109397). Double knockout with cwn-1 results in ALM, CAN and HSN migration defects (PubMed:16109397, PubMed:16516839). Triple knockout with cwn-1 and cfz-2 results in enhanced neuronal cell migratory defects (PubMed:16109397).
messages: Belongs to the Wnt family.
messages: Expressed at the comma stage in pharyngeal muscles and the developing intestine (PubMed:19855022). Detected in all larval forms and adults, but is most abundant in the embryonic stage (PubMed:8510930). At the two-fold stage of embryogenesis, mainly it is expressed in the intestine (PubMed:20711352). During late embryogenesis, before hatching, it is expressed in the posterior pharyngeal bulb and the pharyngeal-intestine (PubMed:20711352). After the L1 stage of larval development it is expressed in the anterior part of the animal in tissues including the pharynx, body wall muscle and ventral cord neurons (PubMed:20711352).
messages: Expressed in intestine, pharynx, anterior body wall muscle, vulva, some pharyngeal neurons and SMD head neurons (PubMed:19855022, PubMed:19561603, PubMed:22022276). Expressed along the boundary between the intestine and muscle or hypodermis, but is also expressed in the hypodermis in cells including seam cells (PubMed:22022276).
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1 (PubMed:19855022). In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore (PubMed:19855022). Together with Wnt ligand cwn-1, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219). May act through the wnt receptor cfz-2 to regulate QR neuroblast descendant migration, and to direct ALM migration (PubMed:16109397). Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397). In addition, together with wnt ligand cwn-1, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603). Through the cam-1 receptor also probably regulates the outgrowth of neurites from RME GABAergic motor neurons (PubMed:20711352). May act redundantly with other Wnt ligands such as cwn-1 and mom-2 to control seam cell polarity (PubMed:22022276).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: extracellular matrix

6239:CELE K07G5.2
gene id: 6239:CELE_K07G5.2
uniprot id: Q21302
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

6239:CELE T12A2.12
gene id: 6239:CELE_T12A2.12
uniprot id: P54126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE C46E1.3
gene id: 6239:CELE_C46E1.3
uniprot id: Q7YTQ6
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

6239:CELE M7.2
gene id: 6239:CELE_M7.2
uniprot id: H9G2T2
uniprot id: Q21592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

6239:CELE C13C4.2
gene id: 6239:CELE_C13C4.2
uniprot id: O01931
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y48B6A.1
gene id: 6239:CELE_Y48B6A.1
uniprot id: Q9U2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

6239:CELE Y54E10A.7
gene id: 6239:CELE_Y54E10A.7
uniprot id: Q9N3F3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

6239:CELE C16A11.1
gene id: 6239:CELE_C16A11.1
uniprot id: O76584
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family.
messages: Expressed in ADL and ASH neurons.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Mediates the transduction of food and serotonin signals, which modulates the avoidance response to the odorant octanol. Has a role in lifespan to promote longevity.
messages: Slow to respond to octanol.

6239:CELE T19H12.5
gene id: 6239:CELE_T19H12.5
uniprot id: O01608
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE D2045.5
gene id: 6239:CELE_D2045.5
uniprot id: Q18984
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F40F4.6
gene id: 6239:CELE_F40F4.6
uniprot id: A0A131MBU3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expressed in the posterior cells of the intestine in L4 larva.
messages: Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity.
messages: RNAi-mediated knockdown in larvae results in reduced survival following infection with the pathogenic bacterium P.luminescens. RNAi-mediated knockdown in a glp-1 e2141 mutant background (in which germ cells are deleted) rescues the increased lifespan phenotype of the glp-1 mutant.
messages: Secreted
messages: Up-regulated following infection with P.luminescens subsp Hb and E.faecalis bacteria.

6239:CELE F09E5.2
gene id: 6239:CELE_F09E5.2
uniprot id: Q19265
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

6239:CELE F25B5.1
gene id: 6239:CELE_F25B5.1
uniprot id: Q09313
names: Function
messages: May have a role in tumor suppression.

6239:CELE C43C3.3
gene id: 6239:CELE_C43C3.3
uniprot id: Q09276
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expression is first apparent in bean-stage embryos, peaks in late embryogenesis, reduces in L1 larvae and is negligible in later larval stages and adults.
messages: In the embryo, expressed in the excretory cell and, during dendrite formation, in the non-neuronal cells surrounding the sensory neurons, including hypodermal cells.
messages: Monomer under reducing conditions. Homodimer under non-reducing conditions. May also form higher order oligomers.
messages: Proteolytically cleaved and secreted in vitro.
messages: Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation (PubMed:7705621). Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development (PubMed:19344940, PubMed:34115759).
messages: Secreted
messages: dendrite

6239:CELE ZK177.6
gene id: 6239:CELE_ZK177.6
uniprot id: Q09373
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat CDC20/Fizzy family.
messages: Chromosome
messages: Cytoplasm
messages: Expressed in oocytes at the prometaphase and metaphase of meiosis I (at protein level). Expressed in early embryo at the prometaphase and metaphase of mitosis (at protein level).
messages: Plays a role in metaphase-anaphase transition during meiosis I (PubMed:12498686). Required for embryonic anterior-posterior axis formation (PubMed:11832245).
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:12498686). Embryos are arrested at the metaphase-anaphase transition of meiosis I and lack formation of polar bodies (PubMed:12498686). In addition, causes a loss of asymmetric cell division and par-2 mislocalization in the one-cell embryo followed by an arrest at the one-cell stage (PubMed:11832245).

6239:CELE T19E7.5
gene id: 6239:CELE_T19E7.5
uniprot id: Q22594
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F58D5.4
gene id: 6239:CELE_F58D5.4
uniprot id: G5EDA5
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Interacts with ndk-1.
messages: Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf (PubMed:23900546, PubMed:11882296). In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation (PubMed:11882296, PubMed:26510792). Plays a role in meiotic recombination events (PubMed:26510792). Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells (PubMed:11882296).
messages: RNAi-mediated knockdown causes sterility characterized by a lack of oocytes. In a ksr-1 n2526 mutant background, causes larval lethality.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE C50D2.2
gene id: 6239:CELE_C50D2.2
uniprot id: O44798
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK154.3
gene id: 6239:CELE_ZK154.3
uniprot id: P12456
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tubulin family.
messages: Defective touch receptor neuron synaptic transmission with reduced levels of rab-3 at synapses, conferring touch insensitivity. Irregular touch receptor neuron shape. The heterozygous mutant, but not the null mutant, rescues the touch sensitivity defect in the mec-15 single mutant.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Expressed primarily in touch receptor neurons.
messages: Mec-7 beta-tubulin is required for the production of 15-protofilament microtubules.
messages: TTubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:19652181).
messages: cytoskeleton

6239:CELE T05F1.1
gene id: 6239:CELE_T05F1.1
uniprot id: A5JYX8
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although it contains a putative aminopeptidase domain, the critical residues for Zn(2+) binding and thus for catalytic activity are not conserved suggesting that nra-2 lacks peptidase activity.
messages: Belongs to the nicastrin family.
messages: Endoplasmic reticulum membrane
messages: Expressed in body wall, pharyngeal, and vulval muscles, excretory canal cell, head and motor neurons, and vulval epithelium.
messages: Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER) (PubMed:19609303, PubMed:24567339). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER (PubMed:19609303). Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR (PubMed:19609303). Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions (PubMed:15990870, PubMed:19609303). In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel (PubMed:24567339).
messages: May interact with the levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) (PubMed:15990870). May interact with nra-4 in the ER (PubMed:19609303).
messages: RNAi-mediated knockdown causes a moderate resistance to nicotine-induced paralysis (PubMed:15990870). RNAi-mediated knockdown in neurons in a hyperactive mec-10 (A673V) mutant background increases touch neuron (TRN) cell death (PubMed:24567339).

6239:CELE C14B1.5
gene id: 6239:CELE_C14B1.5
uniprot id: P49958
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase (By similarity).
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase.

6239:CELE F25H2.8
gene id: 6239:CELE_F25H2.8
uniprot id: Q93571
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function (PubMed:12763049).
messages: Cytoplasm
messages: Expression begins during gastrulation and continues during all subsequent stages.
messages: In males and hermaphrodites, late-onset paralysis of muscular functions required for locomotion and defecation. In addition, hermaphrodites show a progressive egg-laying defect, resulting in intrauterine hatching and premature death. Vulva protrusion is often observed with occasional rupture resulting in the projection of internal organs.
messages: In the embryo, expressed in precursor neuron and muscle cells and in other cells such as hypodermal cells. After hatching of L1 larvae and in all subsequent stages, strongest expression in pharyngeal muscle and anal muscle cells. In L4 larvae and adolescent hermaphrodites, also expressed in the vulval muscles. Expression also detected in all four nerve cords and in neurons with weaker levels in all body wall muscles.
messages: Nucleus

6239:CELE F13G3.7
gene id: 6239:CELE_F13G3.7
uniprot id: Q19422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE C14F5.2
gene id: 6239:CELE_C14F5.2
uniprot id: G5EEY6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: At the L1 larval stage, display defects in the positioning of the ventral nerve cord (VNC) axons characterized by axons of PVQ and PVP neurons, but not of RMEV, HSN and AVK neurons, drifting into the opposite VNC side (axon flip-over) (PubMed:19737747). These defects are not enhanced in a zig-4 (gk34) mutant background or in zig-4 (gk34) dig-1 (ky188), zig-4 (gk34) sax-7 (nj48) or zig-4 (gk34) egl-15 (n484) mutant background (PubMed:19737747). In a zig-1, zig-2, zig-4 or zig-5 or zig-8 mutant background, cell body positioning of ASI and ASH head neurons is normal (PubMed:22829780).
messages: Expressed in PVT, AIM and ASI neurons, in vulva and weakly in body wall muscles.
messages: Expression begins at the late L1 larval stage.
messages: Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement.
messages: Secreted

6239:CELE T07C12.9
gene id: 6239:CELE_T07C12.9
uniprot id: Q22279
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

6239:CELE F07B7.10
gene id: 6239:CELE_F07B7.10
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T20B3.1
gene id: 6239:CELE_T20B3.1
uniprot id: Q9XUN8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE T15D6.2
gene id: 6239:CELE_T15D6.2
uniprot id: G5EDP7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE ZK384.3
gene id: 6239:CELE_ZK384.3
uniprot id: Q7JKL9
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE C44B7.1
gene id: 6239:CELE_C44B7.1
uniprot id: Q10920
names: Function
names: Similarity
messages: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).
messages: Belongs to the proteasome subunit p27 family.

6239:CELE ZK1128.6
gene id: 6239:CELE_ZK1128.6
uniprot id: Q09647
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Expressed in embryos and adults.
messages: Expressed in many sensory neurons in amphid.
messages: Monoglutamylase which modifies tubulin, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins (PubMed:32747782). Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin (PubMed:32747782). Involved in side-chain glutamylation of tubulin in sensory cilia (PubMed:20519502, PubMed:27635036, PubMed:29849065). Together with ttll-5 and ttll-11, required for male mating (PubMed:27635036).
messages: RNAi-mediated knockdown at the L1 or L4 larval stages causes a defect in egg-laying.

6239:CELE F28C6.1
gene id: 6239:CELE_F28C6.1
uniprot id: Q19863
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer.
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic lethality and morphological defects in larva (PubMed:27176626). Embryonic lethality is exacerbated on the transcription factor aptf-2 mutant background (PubMed:27176626).
messages: Sequence-specific DNA-binding protein that interacts with enhancer elements to regulate transcription of selected genes (By similarity). Required for neuroblast and epidermal morphogenesis, perhaps acting in cooperation with transcription factor aptf-2 (PubMed:27176626).

6239:CELE F17H10.3
gene id: 6239:CELE_F17H10.3
uniprot id: Q0G826
uniprot id: Q19532
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
messages: Cytoplasm
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)).

6239:CELE Y19D2B.1
gene id: 6239:CELE_Y19D2B.1
uniprot id: Q9XXH2
names: Similarity
messages: Belongs to the tubulin family.

6239:CELE Y11D7A.13
gene id: 6239:CELE_Y11D7A.13
uniprot id: Q9XWQ6
names: Developmental Stage
names: Function
messages: Expressed during late stages of embryogenesis and larval L1 stage.
messages: Probable transcription factor (PubMed:18794349). May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2 (PubMed:18794349).

6239:CELE T12C9.6
gene id: 6239:CELE_T12C9.6
uniprot id: Q27521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C43E11.8
gene id: 6239:CELE_C43E11.8
uniprot id: P91149
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Involved in ER-Golgi transport.

6239:CELE K12H4.7
gene id: 6239:CELE_K12H4.7
uniprot id: P34528
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE D1037.2
gene id: 6239:CELE_D1037.2
uniprot id: Q9TYS4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y47D3A.17
gene id: 6239:CELE_Y47D3A.17
uniprot id: A7DTF3
uniprot id: Q9U2C7
names: Similarity
messages: Belongs to the OSBP family.

6239:CELE K07C11.7
gene id: 6239:CELE_K07C11.7
uniprot id: G8JY31
uniprot id: Q21268
names: Similarity
messages: Belongs to the UPF0046 family.

6239:CELE W10D9.5
gene id: 6239:CELE_W10D9.5
uniprot id: O17287
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom22 family.
messages: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor tomm-20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:21264209).
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown results in impaired mitochondrial homeostasis with the up-regulation of the mitochondrial unfolded protein chaperone hsp-6 and impaired daf-28/insulin secretion.

6239:CELE M18.8
gene id: 6239:CELE_M18.8
uniprot id: G5EFD8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE Y47D3A.12
gene id: 6239:CELE_Y47D3A.12
uniprot id: Q9U2C9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in cells of the ABa lineage at the 24-cell stage of embryogenesis.
messages: Nucleus
messages: Transcription factor (By similarity). Required for mesodermal induction, acting redundantly with transcription factor tbx-38 (PubMed:15056620). Together with tbx-38, acts by inducing cell fates in the AB lineage, thereby playing a role in development of the anterior pharynx (PubMed:15056620).

6239:CELE F21G4.2
gene id: 6239:CELE_F21G4.2
uniprot id: G5EFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE C17E7.3
gene id: 6239:CELE_C17E7.3
uniprot id: A0A163UT97
uniprot id: O16394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE W04D2.3
gene id: 6239:CELE_W04D2.3
uniprot id: Q23157
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE T07C4.6
gene id: 6239:CELE_T07C4.6
uniprot id: Q22289
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells (PubMed:15066124, PubMed:15102704). First detected in the E cell at the 8 cell stage and its daughter Ea and Ep cells until the 24 cell stage (PubMed:15066124, PubMed:15102704). At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells (PubMed:15066124). At the 200 cell stage, detected in two pairs of MS descendant cells (PubMed:15066124). Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis (PubMed:15066124). During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage (PubMed:15066124, PubMed:15102704).
messages: Nucleus
messages: RNAi-mediated knockdown causes about 5% embryonic lethality with 1-10% of hatching larvae displaying posterior morphological defects (PubMed:15892873, PubMed:15102704). Defective intercalation of dorsal hypodermis (PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-8 causes at least 48% of embryos to fail to hatch and those that do display severe morphological defects and die as larvae (PubMed:15892873, PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-8 abolishes muscle expression of vab-7 (PubMed:15102704). RNAi-mediated knockdown at the larval L1 stage causes a decrease in expression of lin-39 at the larval L3 stage (PubMed:24885717). Knockdown in L1 stage larvae, in a lin-39 mutant background, causes abnormal fusion of vulval precursor cells at larval stage L2 (PubMed:24885717).
messages: Transcription factor (By similarity). Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle (PubMed:15066124, PubMed:15102704). Involved in regulating expression of vab-7 (PubMed:15102704). Appears to have partially redundant function to tbx-8 (PubMed:15066124). Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage.

6239:CELE F08B1.1
gene id: 6239:CELE_F08B1.1
uniprot id: Q10038
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Expressed in the pharynx, intestine, neurons and vulval hypodermal cells.
messages: Expressed throughout development.
messages: May interact with pmk-3.

6239:CELE C11E4.3
gene id: 6239:CELE_C11E4.3
uniprot id: Q93205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C17D12.6
gene id: 6239:CELE_C17D12.6
uniprot id: Q9TVY6
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in spermatids, during spermogenesis expression is primarily localized to the pseudopod.
messages: Membrane
messages: Modifying each EGF repeat by changing a central cysteine residue to a tyrosine disrupts the secondary structure as the specific disulfide bridges responsible for this overall structure are not formed. The cysteine to tyrosine mutation when located in EGF-like domains 1,3,4 and 5, causes a complete loss of function. The same mutation in additional EGF-like domains leads to a temperature sensitive sterile phenotype.
messages: Removing the EGF-like repeats in any combination completely abolishes fertilization.
messages: Required for fertilization. May be required for cell adhesion and/or function as a signaling molecule.

6239:CELE Y50D7A.13
gene id: 6239:CELE_Y50D7A.13
uniprot id: A0A0K3ARD1
names: Similarity
messages: Belongs to the peptidase M10A family.

6239:CELE ZK678.1
gene id: 6239:CELE_ZK678.1
uniprot id: Q27365
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Greatly reduced nuclear accumulation of lin-56 protein and increased mRNA levels (PubMed:21196525). No obvious vulval development defects (PubMed:8054684, PubMed:11463372). Double knockout with the synthetic multivulva class B protein lin-15B, dpl-1, efl-1 or lin-35 results in a multiple vulva (Muv) phenotype (PubMed:8054684, PubMed:11463372, PubMed:16624904).
messages: Nucleus
messages: Synthetic multivulva (synMuv) class A protein (PubMed:7982579, PubMed:8054684). SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684). Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway (PubMed:8054684, PubMed:16624904). May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1 (PubMed:11463372). Regulates let-23 basal activity (PubMed:8054684). Required for the correct expression and/or stability of lin-56 (PubMed:21196525).
messages: The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.

6239:CELE Y53G8AR.7
gene id: 6239:CELE_Y53G8AR.7
uniprot id: Q9N3G2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C27A2.3
gene id: 6239:CELE_C27A2.3
uniprot id: Q18235
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a chaperone and as an inhibitor for separase sep-1 (PubMed:27249343, PubMed:28263324). Plays an essential role in maintaining chromosome cohesion prior to meiotic and mitotic anaphase, in cytokinesis and in organizing the spindle and the centrosome (PubMed:12498686). Ubiquitination-dependent degradation at the onset of anaphase is likely to activate sep-1 resulting in the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes (PubMed:12498686, PubMed:23578927). Also required for cortical granule exocytosis (PubMed:17913784).
messages: Chromosome
messages: Cytoplasm
messages: Expressed in germ cells including oocytes.
messages: Forms a complex (via C-terminus) with separase sep-1 (PubMed:12498686, PubMed:23578927, PubMed:27249343, PubMed:28263324). Interaction with ify-1 stabilizes sep-1 (PubMed:27249343, PubMed:28263324). Also maintains the complex in the cytoplasm during interphase and recruits it to chromosomes during the first meiotic division (PubMed:23578927). Interacts with E3 ubiquitin-protein ligase etc-1 (PubMed:23578927).
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:12498686). Embryos are arrested at the one-cell stage (PubMed:12498686). During the first mitotic division, embryos have defects in mitotic spindle formation, and centrosome duplication and positioning (PubMed:12498686). Chromosomes are decondensed, disorganized and accumulate due to a lack of cytokinesis (PubMed:12498686). RNAi-mediated knockdown at the larval stage causes in F1 embryos a loss of chromosome separation during meiosis I and no formation of polar bodies (PubMed:12498686). During meiosis, impaired cortical granule exocytosis (PubMed:17913784). Immediately after fertilization causes a reduction in cyclin cyb-1 protein levels (PubMed:23578927).
messages: Ubiquitinated by etc-1 likely at the onset of anaphase, resulting in its degradation.
messages: spindle

6239:CELE D2030.4
gene id: 6239:CELE_D2030.4
uniprot id: P90789
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

6239:CELE F25H8.2
gene id: 6239:CELE_F25H8.2
uniprot id: Q19788
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

6239:CELE ZC317.3
gene id: 6239:CELE_ZC317.3
uniprot id: G5EEZ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F28D1.2
gene id: 6239:CELE_F28D1.2
uniprot id: Q19872
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in embryos.
messages: Nucleus
messages: Plays a role in meiosis, germline development and oocyte morphogenesis (PubMed:28696027). May play a role in DNA replication (PubMed:28696027). In the germline, involved in the maintenance of transition zone nuclei and in chromosome structure and organization, but not required for mitotic proliferation (PubMed:28696027).
messages: RNAi-mediated knockdown results in embryonic lethality in 10% of animals (PubMed:28696027). Surviving animals have a reduced brood size and abnormal diakinetic oocyte morphology (PubMed:28696027).

6239:CELE B0464.5
gene id: 6239:CELE_B0464.5
uniprot id: Q03563
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Interacts with rsp-3.
messages: Predominantly coexpressed with rsp-3 in adult hermaphrodite germlines.
messages: Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates the RS domain of rsp-3/CeSF2 in vitro.

6239:CELE F28F9.1
gene id: 6239:CELE_F28F9.1
uniprot id: G5EBU4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Detected in a few nuclei in the embryonic head as the embryo reaches morphogenesis stage. Expressed in an increasing number of nuclei as embryonic development progresses such that by the 1.5-fold stage it is detected in a large number of neuronal cells in the head and a few cells in the pharynx. At the 1.5-fold stage, expression is also prominent in motorneurons in the ventral cord and in neurons in tail ganglia. This expression is maintained during the 3-fold stage, but is reduced to undetectable levels in most cells before hatching. By the L1/L2 stage, expression is detected transiently in postembryonic motorneurons.
messages: Expressed in the six touch receptor neurons (TRNs) but not in the FLP and PVD neurons (PubMed:30291162). Expressed in the M4 cholinergic motor neuron (PubMed:25474681).
messages: Nucleus
messages: Transcription factor (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162). Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA (PubMed:12835394). Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162). Promotes touch receptor neuron differentiation by repressing the expression of egl-44 and egl-46 (PubMed:30291162). As egl-44 and egl-46, probably acting as a heterodimer, repress expression of zag-1 in FLP neurons, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162). Required for axon guidance (PubMed:12835395). Involved in the proper development of the pharynx (PubMed:12835395). Required for pharynx isthmus peristalsis, probably via a role in the differentiation of the M4 cholinergic motor neuron (PubMed:25474681). Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter (PubMed:12835394, PubMed:12835395). May also act as a transcriptional activator of the homeodomain ceh-28 (PubMed:25474681).
messages: Worms exhibit a starved appearance, are unable to swallow food and die at the L1 larval stage (PubMed:12835395). RNAi-mediated knockdown causes significant reduction in expression of mec-17 (PubMed:30291162).

6239:CELE T27A1.6
gene id: 6239:CELE_T27A1.6
uniprot id: P90971
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: First expressed during embryogenesis at the 1.5-fold stage, and in very few cells throughout development (PubMed:10716947). Expressed in L1 larvae in the posterior hindgut cells B and F and in later L1 stage in the B daughter cells B.a and B.p (PubMed:10716947). Also expressed in two posterior hypodermal nuclei of the large syncytial cell hyp7 and in the nervous system in two neurons of the lumbar ganglion (PubMed:10716947).
messages: Nucleus
messages: RNAi-mediated knockdown by injection into the gonad results in male progeny with grossly abnormal tails with no spicules (PubMed:10716947). Hermaphrodite progeny are constipated and show backward uncoordination (PubMed:10716947).
messages: Transcription factor (PubMed:28056346). Involved in cell fate determination; required to pattern the posterior hindgut (PubMed:10716947). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346). Required throughout development to repress transcription by unc-3, probably acting by binding to specific promoter elements (PubMed:28056346). Represses expression of VA and VB motor neuron-specific effector genes, such as DEG/ENaC channel del-1 and the innexin inx-12, in DA and DB motor neurons (PubMed:28056346). Represses expression of transcription factor bnc-1, perhaps acting directly, in DA and DB motor neurons (PubMed:28056346).

6239:CELE F45B8.2
gene id: 6239:CELE_F45B8.2
uniprot id: O45523
names: Disruption Phenotype
names: Function
messages: Shown to have a role in viability and embryogenesis.
messages: Sterility and embryonic lethality.

6239:CELE ZK1251.9
gene id: 6239:CELE_ZK1251.9
uniprot id: Q21106
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPRBP/DCAF1 family.
messages: Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex.
messages: Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex.
messages: Nucleus
messages: The DWD boxes are required for interaction with ddb1.

6239:CELE C17E7.8
gene id: 6239:CELE_C17E7.8
uniprot id: B1GRK4
uniprot id: O16391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C07A12.3
gene id: 6239:CELE_C07A12.3
uniprot id: Q17771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R11G1.4
gene id: 6239:CELE_R11G1.4
uniprot id: Q2L6W9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expanded cell bodies and ectopic neurites in many classes of neurons. Overlap of anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) neurites along the anteroposterior axis.
messages: Nucleus
messages: Widely expressed in embryonic and larval neurons that contribute axons to the nerve ring and in hypodermal cells, including lateral seam cells. Also displays a punctate localization in muscle.

6239:CELE LLC1.1
gene id: 6239:CELE_LLC1.1
uniprot id: Q22036
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase C2 family.
messages: Binds 3 Ca(2+) ions.
messages: Expressed in neuronal, but not in GABA-ergic neurons, intestinal, hypodermal and excretory tissues.
messages: RNAi-mediated knockdown prevents neuronal degeneration in a mec-4(u231), deg-1(u38) or gsa-1 gain-of-function mutant background.
messages: Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis (PubMed:10783162). Part of the necrosis cell death pathway (PubMed:12410314). Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa (PubMed:26795495).
messages: The C2 domain associated with the domain III is primarily responsible for calcium binding.
messages: The calpain catalytic domain is essential for in vivo function to promote female sexual development.

6239:CELE Y111B2A.15
gene id: 6239:CELE_Y111B2A.15
uniprot id: O77081
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

6239:CELE F18E9.2
gene id: 6239:CELE_F18E9.2
uniprot id: Q19569
names: Disruption Phenotype
names: Function
names: Induction
messages: May regulate lifespan in response to food availability and oxidative stress.
messages: Reduced lifespan when diet is restricted, and in the presence of the oxidative stress inducer paraquat (PubMed:19783783). Increased pha-4 and cup-4 expression when diet is restricted (PubMed:19783783). RNAi-mediated knockdown reduces lifespan and resistance to the oxidative stress inducer paraquat (PubMed:19627265, PubMed:19783783). RNAi-mediated knockdown in an eat-2 mutant background rescues lifespan, but lifespan remains greater than in wild-type (PubMed:19783783).
messages: Up-regulated when diet is restricted.

6239:CELE Y80D3A.3
gene id: 6239:CELE_Y80D3A.3
uniprot id: Q9U1R1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Expressed in the early embryo, in the mesodermal lineage derived from the MS blastomere.
messages: Nucleus
messages: RNAi-mediated knockdown on an hlh-1 mutant background causes embryos to become paralyzed and arrested at the 2-fold stage.
messages: Required for mesoderm development, including specification of muscle and coelomocyte precursors.

6239:CELE K08F4.11
gene id: 6239:CELE_K08F4.11
uniprot id: O16116
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE F16B4.1
gene id: 6239:CELE_F16B4.1
uniprot id: O61203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y37D8A.13
gene id: 6239:CELE_Y37D8A.13
uniprot id: G5EFD5
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Contains a metallopeptidase domain, but the active site is not conserved, so the protein is not expected to have protease activity.
messages: Defective sex myoblast migration (PubMed:9073451). Motor neuron axon guidance defects with aberrant axon branching in type D motor neurons (PubMed:12783787).
messages: Expressed throughout development (PubMed:8970152, PubMed:12783787, PubMed:22293500). First expressed in several posterior cells of comma stage embryos (PubMed:12783787). Expressed in the excretory cell and in some head neurons in threefold stage embryos (PubMed:12783787). At the L1 stage of larval development expressed in the syncytial hypodermis (PubMed:8970152). From the L1 stage of larval development to adulthood, expressed in head neurons, the excretory cell, excretory gland cells and in the sphincter muscle (PubMed:12783787, PubMed:22293500). From the L4 stage of larval development to adulthood, expressed in hypodermal cells surrounding the vulva (PubMed:12783787).
messages: Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development (PubMed:9073451, PubMed:12783787, PubMed:22293500). Involved in axon branching and guidance of neurons including GABAergic type D motor neurons (PubMed:12783787). Promotes sex myoblast migration and positioning independently of gonad attraction cues (PubMed:9073451, PubMed:12783787). May act downstream of mig-13 in order to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis (PubMed:22293500). Required for coordinated movements (PubMed:12783787).

6239:CELE C18F10.8
gene id: 6239:CELE_C18F10.8
uniprot id: P54129
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE R11G11.13
gene id: 6239:CELE_R11G11.13
uniprot id: O16955
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C56G2.6
gene id: 6239:CELE_C56G2.6
uniprot id: Q09517
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
messages: Expressed from first larval stage to adult.
messages: Expressed in the gut of larva and adult.
messages: Required for branched-chain fatty acid synthesis (such as (omega-1)-methyl-fatty acids) (PubMed:18390550). Catalyzes the reduction of the 3-keto-fatty acyl-CoA intermediate that is formed in each cycle of fatty acid elongation (PubMed:18390550). Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids (PubMed:12905072, PubMed:18390550, PubMed:21926990). Involved in hormone production as it metabolizes 4-androstendione (androst-4-ene-3,17-dione) into testosterone and estrone into estradiol (17beta-estradiol) in vitro, but the physiological steroid substrate is unknown (PubMed:17951538).
messages: Worms exhibit slow and retarded growth, reproductive and molting defects, defects in embryogenesis, and hypersensitivity to cholesterol limitation (PubMed:12905072). Increased polarity and tubulogenesis defects in an allelic series of let-767 (PubMed:21926990).

6239:CELE C16C10.6
gene id: 6239:CELE_C16C10.6
uniprot id: Q09252
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NSRP1 family.
messages: Cytoplasm
messages: Early larval arrest, continued gonad expansion and shortened lifespan. RNAi-mediated knockdown results in continuous distal tip cell migration past the midline during adulthood. In a rnf-5(tm794) mutant background, increased severity of the distal tip cell migration defects.
messages: Expressed in the intestine, nervous system and head neurons in both larvae and adults (PubMed:17850180). Expressed in the distal tip cell (PubMed:22285439).
messages: Nucleus
messages: Required for the cessation of distal tip cell migration at the end of larval morphogenesis.

6239:CELE F22D6.11
gene id: 6239:CELE_F22D6.11
uniprot id: Q19730
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE ZK652.5
gene id: 6239:CELE_ZK652.5
uniprot id: P34663
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus
messages: Probable transcription factor (PubMed:11493519). Required for differentiation of AIY interneurons, acting downstream of LIM/homeobox protein ttx-3 (PubMed:11493519). Modulates gene expression, acting downstream of AMP kinase aak-2/AMPK signaling (PubMed:28560849). Modulates lifespan (PubMed:28560849, PubMed:21713031).
messages: Viable and display no obvious neuroanatomical, morphological or locomotory abnormalities (PubMed:11493519). Lifespan reduced in an isp-1 or nuo-6 mutant background and extends lifespan in the short-lived gas-1 and mev-1 mutants (PubMed:28560849, PubMed:21713031). Expression of the G protein-coupled receptor sra-11 is normal in AIY neurons at the larval L1 stage, but drastically reduced in adults (PubMed:11493519). RNAi-mediated knockdown reduces lifespan in various mitochondrial mutant backgrounds, including isp-1;ctb-1, or clk-1 (PubMed:21713031).

6239:CELE AH6.11
gene id: 6239:CELE_AH6.11
uniprot id: Q09209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE D1069.3
gene id: 6239:CELE_D1069.3
uniprot id: Q6A586
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

6239:CELE D2021.2
gene id: 6239:CELE_D2021.2
uniprot id: H2KYE9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE Y38E10A.5
gene id: 6239:CELE_Y38E10A.5
uniprot id: Q9NAK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C13C4.7
gene id: 6239:CELE_C13C4.7
uniprot id: Q7YTR4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F40F8.8
gene id: 6239:CELE_F40F8.8
uniprot id: D1MN74
uniprot id: Q20232
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE D1069.2
gene id: 6239:CELE_D1069.2
uniprot id: A0A0K3AWU9
uniprot id: O44788
names: Similarity
messages: Belongs to the calponin family.

6239:CELE D2023.7
gene id: 6239:CELE_D2023.7
uniprot id: O17734
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y55H10A.1
gene id: 6239:CELE_Y55H10A.1
uniprot id: Q9TYW1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accessory component of the multisubunit proton-transporting vacuolar (V)-ATPase protein pump.
messages: Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles (By similarity). In the germline, required for the trafficking of the receptor RME-2 to the oocyte cell membrane where it regulates the uptake of yolk proteins (PubMed:22768351). Also, plays an essential role in osmoregulation in the embryo, probably by regulating the proper formation of the eggshell (PubMed:22768351).
messages: Belongs to the vacuolar ATPase subunit S1 family.
messages: Expressed in larvae and adults.
messages: Expressed in pharynx, hypodermis, intestine, vulval hypodermis and the H-shape excretory cell.
messages: Membrane
messages: RNAi-mediated knockdown at the L1 larval stage causes arrest followed by death at the L3/L4 larval stages (PubMed:22768351). RNAi-mediated knockdown at the L4 larval stage does not affect development into adults (PubMed:22768351). However, only 26% of the progeny hatched into larvae which die at the L3 larval stage. RNAi-mediated knockdown at the L4 larval stage or in the germline causes egg compression in their uterus (PubMed:22768351). Fewer oocytes are produced in the oviduct and are endomitotic (PubMed:22768351). This results in a reduced rate of ovulation over time (PubMed:22768351). Oocytes fail to endocytose vitellogenin due to a failure to traffic receptor rme-2 to the cell membrane (PubMed:22768351). Also, embryos display osmotic sensitivity and defect in osmoregulation and cytokinesis probably due to an abnormal eggshell (PubMed:22768351).

6239:CELE D1014.3
gene id: 6239:CELE_D1014.3
uniprot id: Q18921
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

6239:CELE T20F7.3
gene id: 6239:CELE_T20F7.3
uniprot id: O02167
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

6239:CELE Y60A3A.1
gene id: 6239:CELE_Y60A3A.1
uniprot id: Q23023
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: During embryonic development unc-51 is expressed extensively, particularly in the head region of late embryos. In the larval stages, expression appears to be restricted to neurons.
messages: Interacts with unc-14 and vab-8 (PubMed:15539493). Interacts (via C-terminus) with atg-13 (PubMed:19377305). Interacts (via the LIR motif) with lgg-1; the interaction is direct (PubMed:26687600).
messages: Protein kinase important for axonal elongation and axonal guidance (PubMed:7958904, PubMed:15539493). Functions in the CAN axons to direct both anterior and posterior migrations (PubMed:15539493). Phosphorylates both unc-14 and vab-8 (PubMed:15539493). Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation (PubMed:12958363, PubMed:17890369, PubMed:19377305, PubMed:26687600). Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells (PubMed:19377305). Plays a role in mitophagy during limited food availability (PubMed:30133321). Regulates cell size (PubMed:17890369). Plays a role in male tail ray pattern formation (PubMed:17890369). May be required for normal dauer morphogenesis (PubMed:12958363).
messages: The LIR motif (LC3-interacting region) is required for its interaction with lgg-1.
messages: Worms exhibit various abnormalities in axonal elongation and axonal structures (PubMed:7958904). RNAi-mediated knockdown causes abnormalities in constitutive dauer formation in daf-2 e1370 mutant including a lack of autophagosome formation (PubMed:12958363).

6239:CELE ZK662.4
gene id: 6239:CELE_ZK662.4
uniprot id: Q27395
names: Disruption Phenotype
names: Function
names: Miscellaneous
messages: No obvious vulval development defects (PubMed:8054684, PubMed:11463372). Double knockout with the synthetic multivulva class A protein lin-15A results in a multiple vulva (Muv) phenotype (PubMed:8054684). Double knockout with the programmed cell death regulator mcd-1 results in 100% lethality during the L1 stage of larval development (PubMed:17237514).
messages: Synthetic multivulva (synMuv) class B protein (PubMed:7982579, PubMed:8054684). SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684, PubMed:11463372). Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development (PubMed:8054684). Regulates let-23 basal activity (PubMed:8054684).
messages: The proteins lin-15A and lin-15B are produced from a single precursor mRNA with non-overlapping transcripts where lin-15B is the upstream transcript and lin-15A is the downstream one. The precursor mRNA is cleaved at the polyadenylation site and a 22-nucleotide SL2 leader sequence is trans-spliced to the 5'-end of lin-15A to allow its translation.

6239:CELE C56C10.8
gene id: 6239:CELE_C56C10.8
uniprot id: Q18885
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Cytoplasm
messages: Expressed throughout development.
messages: May be a general transcription factor that can form a stable complex with RNA polymerase II (By similarity). May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity). In response to heat stress, plays a role in modulating the unfolded protein response by negatively regulating the accumulation of proteins such as the chaperone protein hsp-4 in the endoplasmic reticulum (PubMed:22957041). Required to suppress apoptosis in neuronal and intestinal cells to promote development (PubMed:12944970).
messages: May be part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of icd-2 and icd-1 (via NAC-A/B domains).
messages: Mitochondrion
messages: Nucleus
messages: RNAi-mediated knockdown mostly results in embryonic lethality, but embryos that do hatch produce larvae with a large number of apoptotic cell corpses, which are first present at the comma stage of development (PubMed:12944970). Surviving animals are uncoordinated (PubMed:12944970). RNAi-mediated knockdown results in increased neuronal and intestinal cell death and a reduced number of male tail rays in larvae (PubMed:12944970). RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type (PubMed:22957041). RNAi-mediated knockdown in adults results in embryos with severe morphological defects and high numbers of enlarged bi-refringent lipofuscin glo-1-positive granules in their gut cells, and increased cell death and degeneration (PubMed:22957041). These embryos also have increased expression of the endoplasmic reticulum-specific chaperone protein hsp-4 in regions of the embryo that contain gut and epithelial cells (PubMed:22957041).

6239:CELE C53B7.2
gene id: 6239:CELE_C53B7.2
uniprot id: Q18805
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F23C8.6
gene id: 6239:CELE_F23C8.6
uniprot id: Q9TXI3
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE W09C2.3
gene id: 6239:CELE_W09C2.3
uniprot id: F5GU98
uniprot id: G5EC04
uniprot id: G5EC39
uniprot id: G5EFR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y71D11A.5
gene id: 6239:CELE_Y71D11A.5
uniprot id: Q95Y52
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Expressed in the dorsal nerve cord of L1 larva and on the dorsal side only of L4 larva and adults.
messages: Expressed in the nervous system, with high expression in cholinergic motor neurons and weak expression in GABAergic motor neurons.
messages: Presynaptic cell membrane
messages: Probable component of a ligand-gated anion channel. Negatively regulates synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. Role in synaptic vesicle release kinetics may be in association with the ligand-gated ion channel protein acc-4.
messages: Viable, with normal growth, reproduction and locomotion. Increased sensitivity to the acetylcholine esterase inhibitor aldicarb, but normal sensitivity to levamisole, an agonist for postsynaptic acetylcholine receptors on muscles. In response to induced acetylcholine release, the amplitude and rise phase of excitatory postsynaptic currents (eEPSCs) during synaptic transmission is as wild-type, but there is prolonged and slow decay of eEPSCs during the late phase of synaptic transmission, which results in increased release of synaptic vesicles in cholinergic motor neurons.
messages: axon
messages: synaptic vesicle

6239:CELE F10G7.7
gene id: 6239:CELE_F10G7.7
uniprot id: Q19321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F53E10.6
gene id: 6239:CELE_F53E10.6
uniprot id: P91318
names: Similarity
messages: Belongs to the RRP15 family.

6239:CELE F47C10.7
gene id: 6239:CELE_F47C10.7
uniprot id: A0A168H5N7
uniprot id: O01562
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F23C8.9
gene id: 6239:CELE_F23C8.9
uniprot id: Q9TXI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress.

6239:CELE B0304.9
gene id: 6239:CELE_B0304.9
uniprot id: Q3Y412
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC239.3
gene id: 6239:CELE_ZC239.3
uniprot id: P91559
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE C56E10.1
gene id: 6239:CELE_C56E10.1
uniprot id: Q18895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE M03A8.2
gene id: 6239:CELE_M03A8.2
uniprot id: Q21480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Interacts with epg-6; the interaction is direct.
messages: Lipid droplet
messages: Lipid transfer protein involved in autophagosome assembly and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates (PubMed:21802374, PubMed:25124690). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source to the IM for membrane expansion (By similarity). Involved in autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes, which is essential for maintaining nucleotide homeostasis (PubMed:30102152).
messages: Preautophagosomal structure membrane

6239:CELE ZK757.1
gene id: 6239:CELE_ZK757.1
uniprot id: P34679
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y40B10A.1
gene id: 6239:CELE_Y40B10A.1
uniprot id: Q3LFN1
uniprot id: Q965W1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE C29H12.3
gene id: 6239:CELE_C29H12.3
uniprot id: Q18312
names: Disruption Phenotype
names: Function
names: PTM
messages: May be phosphorylated and activated by egl-4.
messages: Modulates chemotaxis responses by regulating positively the sensitivity to CO2 levels in BAG neurons and by regulating negatively the sensitivity to quinine in ASH sensory neurons.
messages: RNAi-mediated knockdown in ASH sensory neurons results in hypersensitivity to dilute quinine.

6239:CELE T05B4.7
gene id: 6239:CELE_T05B4.7
uniprot id: O16415
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F13A7.1
gene id: 6239:CELE_F13A7.1
uniprot id: O17799
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F55A3.5
gene id: 6239:CELE_F55A3.5
uniprot id: Q9N5S2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE C17A2.8
gene id: 6239:CELE_C17A2.8
uniprot id: O16537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE B0336.6
gene id: 6239:CELE_B0336.6
uniprot id: Q10929
names: Similarity
messages: Belongs to the ABI family.

6239:CELE C52D10.12
gene id: 6239:CELE_C52D10.12
uniprot id: A3QM97
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the ACDP family.
messages: Highly expressed in the intestine and in neurons, but it is also expressed in a variety of tissues including the pharynx, hypodermis, rectum and in muscles.
messages: No visible phenotype. Double knockout with cnnm-3 results in increased levels of intestinal Mg(2+) and reduced levels in other tissues. This Mg(2+) deficiency in tissues leads to a reduced lifespan, 100% sterility, and smaller animals that exhibit a developmental delay with defective gonad development and which therefore do not produce oocytes or form vulva. In addition, the gonad development defect in the cnnm-1 and cnnm-3 double knockout is rescued when the AMPK alpha subunit aak-2 is also knocked out. Quintuple knockout with cnnm-2, cnnm-3, cnnm-4 and cnnm-5 results in a reduced lifespan and 100% sterility.
messages: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-2, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.

6239:CELE C04E6.10
gene id: 6239:CELE_C04E6.10
uniprot id: O01468
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y74C9A.5
gene id: 6239:CELE_Y74C9A.5
uniprot id: Q9N4D6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm
messages: May function as a negative feedback regulator of TOR function.
messages: Nucleus
messages: RNAi-mediated knockdown results in decreased lifespan.

6239:CELE R06C7.6
gene id: 6239:CELE_R06C7.6
uniprot id: Q21775
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.
messages: Monomer.

6239:CELE T05C12.5
gene id: 6239:CELE_T05C12.5
uniprot id: Q22226
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

6239:CELE F54D11.2
gene id: 6239:CELE_F54D11.2
uniprot id: Q22992
names: Function
messages: Influences the activity of genes involved in vulval development.

6239:CELE K10C3.2
gene id: 6239:CELE_K10C3.2
uniprot id: Q9XU56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

6239:CELE F25D7.3
gene id: 6239:CELE_F25D7.3
uniprot id: Q93560
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in hypodermal, vulval, intestinal and distal tip cells.
messages: Gonadal migration defects with premature dorsal turning of distal tip cells in the hermaphrodite gonad (PubMed:24613396, PubMed:24968003). Defective dauer formation, shortened lifespan and retarded terminal differentiation of seam cells with incomplete adult alae synthesis (PubMed:24613396). Suppresses the precocious seam cell terminal differentiation and gonadal migration defects seen in dre-1 mutants (PubMed:24613396). Weak dumpy phenotype and partially penetrant embryonic lethality (PubMed:24968003). Reduced expression of the transcription factor bed-3 which is involved in vulval development and failed division of vulval precursor cell descendents (PubMed:26234645). RNAi-mediated knockdown impairs the expression of several hypodermis-specific genes; reduces levels of clo-124 mRNA and increases levels of lin-29 mRNA (PubMed:32417234). RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:21408209).
messages: In distal tip cells, expressed from mid-L2 when gonadal outgrowth initiates (PubMed:24613396). By mid-L3, just prior to the dorsal gonadal turn, levels drop dramatically (PubMed:24968003). In seam and hypodermal cells, levels are largely constant throughout larval development except for a transient peak early in L4 (PubMed:24613396).
messages: Interacts with dre-1; the interaction targets blmp-1 for proteasomal degradation (PubMed:24613396, PubMed:24968003). Interacts with ldb-1 and ham-3 (PubMed:32417234).
messages: Nucleus
messages: Transcription factor which binds to enhancer elements in the promoter region of genes (PubMed:26234645). Regulates the expression of the transcription factor bed-3 to control vulval development (PubMed:26234645, PubMed:32417234). Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396). Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Ubiquitinated by the SCF(dre-1) complex, leading to its degradation by the proteasome.

6239:CELE W01A11.1
gene id: 6239:CELE_W01A11.1
uniprot id: Q23068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Endoplasmic reticulum membrane

6239:CELE T21B10.5
gene id: 6239:CELE_T21B10.5
uniprot id: A0A163UT06
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Broadly expressed in tissues at the L1 larval stage (PubMed:29702639). In the male germline, first expressed in primary spermatocytes at the L4 larval stage and expression increases as spermatocyte differentiation progresses (PubMed:29702639).
messages: Expressed in the germline (PubMed:29702639). Predominantly expressed in primary spermatocytes (PubMed:29702639). Also expressed in the oocyte-producing germline of hermaphrodites (PubMed:29702639).
messages: Histone methyltransferase that specifically mono- and di-methylates 'Lys-4' of histone H3 in vitro (PubMed:24685137). Does not tri-methylate 'Lys-4' of histone H3 in vitro (PubMed:24685137). Promotes spermatid development and fertility by positively regulating the transcription of spermatocyte-specific genes in primary spermatocytes (PubMed:29702639). Together with spr-5, required for transgenerational fertility (PubMed:24685137).
messages: Nucleus
messages: RNAi-mediated knockdown partially suppresses the sterility of spr-5 mutants (by101) and results in a slightly increased number of eggs laid as compared to the spr-5 single mutant.

6239:CELE T05G11.3
gene id: 6239:CELE_T05G11.3
uniprot id: Q9XXJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T13F2.8
gene id: 6239:CELE_T13F2.8
uniprot id: H2L2G6
uniprot id: Q94051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Homooligomer containing 14-16 monomers per oligomer.
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

6239:CELE C41C4.5
gene id: 6239:CELE_C41C4.5
uniprot id: H2FLG0
uniprot id: Q09274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Expressed in body wall muscle.
messages: Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development.
messages: Membrane

6239:CELE C33H5.6
gene id: 6239:CELE_C33H5.6
uniprot id: Q18404
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE AH6.6
gene id: 6239:CELE_AH6.6
uniprot id: Q09204
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE R07B7.6
gene id: 6239:CELE_R07B7.6
uniprot id: I2HA85
uniprot id: Q21796
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE ZC64.4
gene id: 6239:CELE_ZC64.4
uniprot id: G5EEA1
names: Caution
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in larvae and adults in neurons in the anterior ganglia (PubMed:10421632). Expressed in the precursor of serotonergic ADF neurons (PubMed:16168406). Expressed in the SMB sensory/inter/motor neurons at larval stage L1 (PubMed:26305787).
messages: Expressed in the AWB sensory neurons and in one RME motor neuron (RMEV), two RMD motor neurons (RMDL and RMDR), the RID, RIV, SAA and SIA interneurons and the SMB sensory/inter/motor neurons.
messages: Interacts with transcription factor sox-2.
messages: It has been reported that lim-4 is expressed in the SIA interneurons (PubMed:10421632). However, a subsequent report suggests that this was a mis-identification, instead indicating that the correct cell type is the SMB sensory/inter/motor neuron (PubMed:26305787).
messages: Nucleus
messages: Transcription factor that binds to the promoter of target genes (PubMed:26305787, PubMed:16168406, PubMed:26341465). Regulates genes involved in serotonin synthesis and release in serotonergic ADF neurons (PubMed:26305787, PubMed:16168406). Involved in specification of neuron cell fate, olfactory receptor expression, locomotion, and foraging behavior (PubMed:10421632, PubMed:26305787). Required in AWB olfactory neurons to repress AWC cell fate and promote the AWB cell fate during early development (PubMed:10421632). Cooperates with additional factors to direct the differentiation of the olfactory neurons, functioning with the transcription factor sox-2 to suppress AWC terminal differentiation and promote AWB neuron differentiation (PubMed:26341465). Involved in regulating terminal specification and maintenance of the SMB sensory/inter/motor neurons (PubMed:26305787). Plays a role in regulation of RID motor neuron differentiation, but is dispensable for motor axon outgrowth in the dorsal nerve cord (PubMed:14568548). May regulate its own expression (PubMed:10421632, PubMed:26305787).

6239:CELE W08E3.1
gene id: 6239:CELE_W08E3.1
uniprot id: P91918
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: cytosol

6239:CELE F26H9.8
gene id: 6239:CELE_F26H9.8
uniprot id: G5EF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

6239:CELE C14C10.5
gene id: 6239:CELE_C14C10.5
uniprot id: N1NTN5
uniprot id: Q17971
names: Similarity
messages: Belongs to the BLM10 family.

6239:CELE Y69A2AR.18
gene id: 6239:CELE_Y69A2AR.18
uniprot id: Q95XJ0
names: Similarity
messages: Belongs to the ATPase gamma chain family.

6239:CELE E02A10.1
gene id: 6239:CELE_E02A10.1
uniprot id: Q93425
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE F31D5.2
gene id: 6239:CELE_F31D5.2
uniprot id: Q19932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE M01D7.7
gene id: 6239:CELE_M01D7.7
uniprot id: G5EGU1
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

6239:CELE C06B8.8
gene id: 6239:CELE_C06B8.8
uniprot id: O17570
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

6239:CELE F59D12.4
gene id: 6239:CELE_F59D12.4
uniprot id: G5EGU4
names: Similarity
messages: Belongs to the glypican family.

6239:CELE ZK632.8
gene id: 6239:CELE_ZK632.8
uniprot id: P34212
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells (PubMed:24843160).
messages: Golgi apparatus
messages: RNAi-mediated knockdown results in disrupted clearance of intracellular pathogen N.parisii from intestinal cells.

6239:CELE R13G10.1
gene id: 6239:CELE_R13G10.1
uniprot id: P48996
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development (PubMed:7954812, PubMed:3779843, PubMed:26641248, PubMed:8939870, PubMed:14660541, PubMed:22393255, PubMed:19119011). Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase (PubMed:8939870). Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome (PubMed:14660541, PubMed:9458050). Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes (PubMed:22393255). As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites (PubMed:11937488). Also plays a role in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway (PubMed:23884442).
messages: Chromosome
messages: Component of the dosage compensation complex, which contains the mix-1/SMC2 and dpy-27/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:8939870, PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011). Within the complex, interacts with dpy-28, mix-1, dpy-26 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:9458050, PubMed:28301465). Interacts with dpy-21 (PubMed:14660541). Interacts with dpy-28; the interaction is required for dpy-28 protein stability and dpy-28 association with the X chromosome (PubMed:18198337). Interacts with smcl-1 (PubMed:28301465).
messages: Consists of two putative central coiled-coil regions flanked by putative globular regions at the N- and C-termini.
messages: Expressed in embryos and early-staged larvae (PubMed:7954812). Also expressed in adult gut nuclei (PubMed:14660541).
messages: Nucleus
messages: RNAi-mediated knockdown causes derepression of X chromosome linked genes in embryos and in larval stages L1 and L3 (PubMed:26641248). Leads to an increase of 'Lys-16' acetylation of histone H4 (H4K16ac) on hermaphrodite X chromosomes (PubMed:22393255). In the TOR complex 2 mutant background rict-1, suppresses the growth delay and elevated body fat index (PubMed:23884442). In a sex-1 mutant background, leads to high XX-specific embryonic lethality (PubMed:19119011).

6239:CELE K07H8.6
gene id: 6239:CELE_K07H8.6
uniprot id: P18948
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance (PubMed:24957743).
messages: RNAi-mediated knockdown causes a reduction in the uptake of cholesterol analog dehydroergosterol (DHE). Simultaneous RNAi-mediated knockdown of zmp-2 prevents a reduction in survival upon heat stress.
messages: Secreted
messages: Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

6239:CELE Y66D12A.22
gene id: 6239:CELE_Y66D12A.22
uniprot id: Q9Y0V6
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3 copies of tim-10/tin-10, named soluble 70 kDa complex. The complex associates with the tim-22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim-10/tin-10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
messages: Worms a small body size, reduced number of progeny produced and partial embryonic lethality due to defects in import of proteins into mitochondria.

6239:CELE ZC513.8
gene id: 6239:CELE_ZC513.8
uniprot id: G5ED38
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C07E3.2
gene id: 6239:CELE_C07E3.2
uniprot id: O17580
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOC2 family.
messages: Nucleus
messages: Required for normal somatic gonad development and for regulation of germline development and proliferation.
messages: Worms exhibit slow growth and sterility caused by germline proliferation defective phenotype (Glp) or proximal germ cell proliferation abnormal phenotype (Pro).

6239:CELE C32C4.2
gene id: 6239:CELE_C32C4.2
uniprot id: D5MCS1
uniprot id: H2FLH4
uniprot id: Q18352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE T16G12.7
gene id: 6239:CELE_T16G12.7
uniprot id: K8FE09
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE Y47G6A.6
gene id: 6239:CELE_Y47G6A.6
uniprot id: Q9N3S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

6239:CELE Y47D9A.1
gene id: 6239:CELE_Y47D9A.1
uniprot id: Q9N4V2
uniprot id: Q9N4V3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

6239:CELE T05A1.5
gene id: 6239:CELE_T05A1.5
uniprot id: Q2XN03
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0563.2
gene id: 6239:CELE_B0563.2
uniprot id: Q17526
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE F41B5.10
gene id: 6239:CELE_F41B5.10
uniprot id: O16677
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F01E11.5
gene id: 6239:CELE_F01E11.5
uniprot id: Q19084
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the pharyngeal neurons, MCL/R and NSML/R and the AS group of amphidial sensory neurons, ASEL/R, AGSL/R, ASHL/R and ASIL/R.
messages: G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. Expression in amphidial sensory neurons suggests a role in chemosensation.

6239:CELE F28D1.11
gene id: 6239:CELE_F28D1.11
uniprot id: Q9XVV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPM3 family.
messages: Endoplasmic reticulum membrane
messages: Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.

6239:CELE ZC262.3
gene id: 6239:CELE_ZC262.3
uniprot id: P34595
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F34D6.2
gene id: 6239:CELE_F34D6.2
uniprot id: O17184
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F53A3.4
gene id: 6239:CELE_F53A3.4
uniprot id: C7IVR4
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the linker cell just before it dies.
messages: In males, promotes linker cell survival.
messages: In males, required for non-apoptotic death of the linker cell once it has finished guiding gonad elongation at the end of larval development. May be involved in nuclear envelope crenellation in the linker cell.
messages: RNAi-mediated knockdown causes the survival of the linker cell in 16 percent of animals.
messages: The coiled-coil domains in isoform d are important for linker cell death.

6239:CELE K03A1.6
gene id: 6239:CELE_K03A1.6
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE K10B3.1
gene id: 6239:CELE_K10B3.1
uniprot id: G4S035
uniprot id: G5ED15
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE E02H1.1
gene id: 6239:CELE_E02H1.1
uniprot id: Q09522
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.
messages: nucleolus

6239:CELE B0310.1
gene id: 6239:CELE_B0310.1
uniprot id: Q10937
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T12A2.1
gene id: 6239:CELE_T12A2.1
uniprot id: Q22419
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

6239:CELE T01B11.4
gene id: 6239:CELE_T01B11.4
uniprot id: G5EFU2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE Y73B6A.5
gene id: 6239:CELE_Y73B6A.5
uniprot id: Q07292
uniprot id: V6CJK3
uniprot id: V6CKR7
uniprot id: V6CM38
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Gld-1 binds to the 3'-UTR of lin-45 mRNA and is able to protect nonsense-containing lin-45 mRNA from nonsense mediated decay (NMD).
messages: Interacts with cdf-1 in a zinc-dependent manner which promotes its activity.
messages: Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60 (PubMed:8483497, PubMed:11861555, PubMed:14724126). Required for progression of developing oocytes through the pachytene stage (PubMed:19826475). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Positively regulates lifespan upstream of mek-2 and mpk-1 (PubMed:20624915).
messages: RNAi-mediated knockdown causes a defect in pachytene progression resulting in a proximal gonad devoid of nuclei. The phenotype is more severe in gck-1 (km15) mutant (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915).

6239:CELE R07E5.2
gene id: 6239:CELE_R07E5.2
uniprot id: Q21824
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Homodimer; disulfide-linked, upon oxidation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

6239:CELE Y53G8B.1
gene id: 6239:CELE_Y53G8B.1
uniprot id: Q9N4S0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

6239:CELE C06A8.9
gene id: 6239:CELE_C06A8.9
uniprot id: Q17697
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Membrane

6239:CELE F12F3.1
gene id: 6239:CELE_F12F3.1
uniprot id: H2KZQ7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F29C4.2
gene id: 6239:CELE_F29C4.2
uniprot id: O76367
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6c family.

6239:CELE F13E6.6
gene id: 6239:CELE_F13E6.6
uniprot id: G5EFE1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

6239:CELE C05C8.2
gene id: 6239:CELE_C05C8.2
uniprot id: O16311
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

6239:CELE T04C10.4
gene id: 6239:CELE_T04C10.4
uniprot id: Q22156
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Expressed at steady levels during development and aging.
messages: Nucleus
messages: Positively modulated by global suppression of translation activated via integrated stress response.
messages: RNAi-mediated knockdown abrogates an increase in hydrogen-sulfide production in an mTORC2 subunit rict-1 mutant background.
messages: Transcription factor (By similarity). Involved in positively modulating longevity and stress tolerance, probably acting by positively regulating expression of transsulfuration enzyme cth-2, leading to increased hydrogen sulfide production and therefore increased protein persulfidation, a protective modification of redox-reactive cysteines (PubMed:35181679). May mediate longevity and increased stress resistance induced by mTORC1 suppression (PubMed:35181679).

6239:CELE Y18H1A.13
gene id: 6239:CELE_Y18H1A.13
uniprot id: Q1EPL5
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE Y39A3CR.4
gene id: 6239:CELE_Y39A3CR.4
uniprot id: Q9N408
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of ddp-1/tim-8 and 3 copies of tin-13/tim-13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim-22.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane (By similarity). Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane (By similarity). Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). The ddp-1/tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9.1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins (PubMed:15485840).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of ddp-1/tim-8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.
messages: Worms display mitochondria with an interconnected morphology, presumably due to defects in the assembly of outer membrane fission/fusion components.

6239:CELE R03G5.5
gene id: 6239:CELE_R03G5.5
uniprot id: A8WFK6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE F42A6.7
gene id: 6239:CELE_F42A6.7
uniprot id: Q22037
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan.
messages: telomere

6239:CELE F11F1.6
gene id: 6239:CELE_F11F1.6
uniprot id: O45348
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in body wall muscle.
messages: Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane.
messages: basement membrane

6239:CELE F28D1.10
gene id: 6239:CELE_F28D1.10
uniprot id: P55163
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HEM-1/HEM-2 family.
messages: Cytoplasm
messages: Embryonic lethality with cells differentiating, but failing to become organized (PubMed:11877381). External hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448). RNAi-mediated knockdown results in abherrent inx-3-positive gap junction formation along the adjoining membranes of EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis (PubMed:33238150).
messages: Expressed in neurons.
messages: Interacts with aco-1, gei-13 and gex-2.
messages: Rac effector required for tissue morphogenesis, cell migrations and egg laying (PubMed:11877381). May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Plays a role in the formation of gap junctions between EA and EP endodermal precursor cells in embryos (PubMed:33238150).

6239:CELE D2045.8
gene id: 6239:CELE_D2045.8
uniprot id: Q18986
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE K03B8.9
gene id: 6239:CELE_K03B8.9
uniprot id: P54244
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Postsynaptic cell membrane
messages: Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (PubMed:9860996, PubMed:11273652).
messages: The functional receptor is a heteromer of deg-3 and des-2. Interacts with ric-3; which is required for proper receptor folding.
messages: This locus is redundant or nonessential as suppression of deg-3 function results in wild-type revertants.

6239:CELE F56H6.8
gene id: 6239:CELE_F56H6.8
uniprot id: O45586
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y40B10A.8
gene id: 6239:CELE_Y40B10A.8
uniprot id: Q965W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F19H8.1
gene id: 6239:CELE_F19H8.1
uniprot id: O45380
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
messages: Expressed in all development stages.
messages: In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.
messages: No visible phenotype.

6239:CELE C07G2.3
gene id: 6239:CELE_C07G2.3
uniprot id: P47209
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE C30H6.7
gene id: 6239:CELE_C30H6.7
uniprot id: O45279
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

6239:CELE ZK1098.9
gene id: 6239:CELE_ZK1098.9
uniprot id: P34608
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y71G12B.12
gene id: 6239:CELE_Y71G12B.12
uniprot id: Q3V5I7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated to lgg-3/ATG12; which is essential for autophagy.
messages: Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane (PubMed:24185444). Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzyme promoting atg-3-mediated lgg-1 lipidation (Probable). Furthermore, association with atg-16.2 is required for the nucleation of lgg-1 positive autophagic vesicles (PubMed:24185444).
messages: Most likely a component of a complex at least containing atg-5, lgg-3/ATG12, atg-16.1 and/or atg-16.2 (Probable). Interacts with lgg-3/ATG12 (By similarity). Interacts with atg-16.1 (via N-terminus) and atg-16.2 (via N-terminus) (PubMed:24185444).
messages: Preautophagosomal structure membrane

6239:CELE F10D2.3
gene id: 6239:CELE_F10D2.3
uniprot id: A0A0B7H0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C54G7.2
gene id: 6239:CELE_C54G7.2
uniprot id: G5EC53
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y22D7AL.14
gene id: 6239:CELE_Y22D7AL.14
uniprot id: Q965P2
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

6239:CELE ZC434.8
gene id: 6239:CELE_ZC434.8
uniprot id: Q27535
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

6239:CELE C50F4.12
gene id: 6239:CELE_C50F4.12
uniprot id: Q18746
names: Similarity
messages: Belongs to the mTERF family.

6239:CELE C46H11.9
gene id: 6239:CELE_C46H11.9
uniprot id: Q9GYJ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y77E11A.13
gene id: 6239:CELE_Y77E11A.13
uniprot id: Q9N4A7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.
messages: Belongs to the WD repeat SEC13 family.
messages: COPII-coated vesicle membrane
messages: Component of a heterotertrameric COPII coat complex composed of npp-20 and sec-31 (Probable). Probably part of the GATOR complex.
messages: Endoplasmic reticulum membrane
messages: Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution (PubMed:28122936).
messages: Lysosome membrane
messages: RNAi-mediated knockdown results in embryonic lethality (PubMed:12937276, PubMed:28122936). Causes severe defects in mitosis (PubMed:28122936). Cytokinesis is blocked and nucleus formation is impaired after the first embryonic mitosis (PubMed:12937276). Centrosome assembly during prophase and prometaphase and their subsequent resolution are impaired which results from impaired nuclear import of hcp-4 (PubMed:28122936). Impaired sister chromatin segregation (PubMed:28122936).
messages: nuclear pore complex

6239:CELE C42D8.2
gene id: 6239:CELE_C42D8.2
uniprot id: P05690
names: Caution
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the intestine of adult hermaphrodites.
messages: High sequence similarity with other vitellogenin genes means that assigning functions to individual proteins is difficult; authors sometimes refer to VITs or vitellogenins.
messages: Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). Together with other vitellogenins, may play a role in modulating life-span, acting via induction of autophagy and lysosomal lipolysis (PubMed:26671266).
messages: Secreted
messages: Simultaneous RNAi-mediated knockdown of vitellogenins vit-1, vit-2, vit-3, vit-4 and vit-5 increases life span, causes accumulation of neutral lipid and an increase in lgg-1 foci in the proximal intestine; however, does not affect fertility or pharyngeal pumping rates (PubMed:26671266). Expression of transcription factors pha-4 and daf-16 are increased (PubMed:26671266).

6239:CELE F27E11.3
gene id: 6239:CELE_F27E11.3
uniprot id: G5ECQ2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Displaced anterior nerve ring and neuronal cell migration defects including irregular localization of canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right (but not the left) Q neuroblast (QR) and its descendants (PubMed:16109397, PubMed:9851916). Axon growth and guidance defects whereby some HSN, male CP neurons and CAN extend ectopic axons or branches, and furthermore some HSN irregularly route towards the ventral midline of the body (PubMed:16109397). Disorganized cells of the anterior ganglion which are normally compacted together when they form the head ganglion in wild-type animals (PubMed:16109397). Double knockout with mom-5 or cwn-2 results in enhanced CAN migration defects (PubMed:16109397). Double knockout with Wnt ligands cwn-1, cwn-2, egl-20 or frizzled protein mom-5 rescues the ALM migration defects in the single cfz-2 knockout (PubMed:16109397). Triple knockout with cwn-1 and cwn-2 results in enhanced neuronal cell migratory defects (PubMed:16109397).
messages: Expressed in two pairs of head neurons and throughout the pharynx.
messages: First expressed at the 100-cell stage of embryogenesis. During embryonic elongation, expressed in anterior, posterior and midbody cells of the embryo and in cellular projections. At hatching, expression is restricted to a few cells in the head and a pair of cells in the tail.
messages: Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
messages: Receptor for Wnt proteins (PubMed:19855022, PubMed:20711352). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to involve interactions with G-proteins (Probable). Required for the migration and axon formation and guidance of different neuronal cell types including canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right Q neuroblast (QR) and its descendants (PubMed:16109397). Directs ALM migration through frizzled protein mom-5 and Wnt ligands cwn-1, cwn-2 and egl-20 (PubMed:16109397). May act redundantly with mom-5 to direct CAN migration (PubMed:16109397). Plays a role in the organization of head ganglion cells (PubMed:16109397). Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring and may in addition positively regulate the neurite outgrowth of RME GABAergic motor neurons along the anterior-posterior axis of the body (PubMed:19855022, PubMed:20711352).
messages: The FZ domain is involved in binding with Wnt ligands.

6239:CELE C13C4.5
gene id: 6239:CELE_C13C4.5
uniprot id: O01927
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6239:CELE Y37D8A.26
gene id: 6239:CELE_Y37D8A.26
uniprot id: Q7YTJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE Y39G8B.7
gene id: 6239:CELE_Y39G8B.7
uniprot id: Q9U2J2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K05B2.4
gene id: 6239:CELE_K05B2.4
uniprot id: Q9GYN3
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE C50H11.1
gene id: 6239:CELE_C50H11.1
uniprot id: O16481
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F54F2.2
gene id: 6239:CELE_F54F2.2
uniprot id: P34447
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in somatic cells throughout development (at protein level) (PubMed:23263989). Isoform a: Predominantly expressed in embryos and adults (at protein level) (PubMed:23263989). Isoform c: Abundant at larval stages (at protein level) (PubMed:23263989).
messages: Isoform a: Expressed at high levels in maturing oocytes, but at low levels in the rest of the germ line (at protein level) (PubMed:23263989). Isoform a: Not expressed in the pharynx, germ line and tail (PubMed:27039057). Isoform c: Not expressed in the germ line (at protein level) (PubMed:23263989). Isoform c: Uniformly expressed (PubMed:27039057).
messages: Multimer; in vitro (PubMed:23806335). Interacts (via C-terminus) with dot-1.1 to form a heterodimer known as the zfp-1-dot-1.1 complex or DotCom complex (PubMed:23806335).
messages: Nucleus
messages: RNAi-mediated knockdown results in developmental defects such as slow growth, protruding vulva, and a reduced brood size (PubMed:16710447). RNAi-mediated knockdown results in germ line defects, resulting in no embryos or impaired oogenesis (PubMed:23263989). RNAi-mediated knockdown suppresses the multivulval phenotype of the lin-15A-lin15B n765 mutant (PubMed:16507136, PubMed:16710447). RNAi-mediated knockdown shortens the lifespan of daf-2 e1370 mutants (PubMed:27039057).
messages: Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription (PubMed:23806335). Recognizes and binds histone H3 methylated at 'Lys-4' (H3K4me) at the promoters of target genes (PubMed:23263989). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes (PubMed:23806335). In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated gene expression (PubMed:21980302). Thus, most likely via this mechanism, in response to stress, it confers a protective role against neuronal necrosis (PubMed:25422944). Plays a role in Insulin/IGF-1-like signaling (IIS)- and diet restriction-mediated lifespan extension by controlling daf-16/FOXO and pha-4/FOXA recruitment to target promoters (PubMed:27039057). May negatively regulate the expression of genes required for vulval development (PubMed:16507136, PubMed:16710447). May play a role in axon guidance in D-type motor neurons (PubMed:24066155). May suppress sensitivity to RNAi (PubMed:16507136).
messages: Required for migration of HSN motor neurons during embryogenesis.
messages: The PHD-type zinc finger 1 most likely mediates nuclear localization.
messages: The ePHD2 domain folds as an integrated structural module comprizing the C2HC pre-PHD-type 2 zinc finger and the PHD-type 2 zinc finger. It mediates non-specific binding to dsDNA, but does not bind histones in contrast to many PHD-type zinc fingers.

6239:CELE Y9C12A.1
gene id: 6239:CELE_Y9C12A.1
uniprot id: Q9N4P4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y46H3A.6
gene id: 6239:CELE_Y46H3A.6
uniprot id: A0A0K3ASG4
uniprot id: O61397
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE C04F5.7
gene id: 6239:CELE_C04F5.7
uniprot id: Q9GZD1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H30A04.1
gene id: 6239:CELE_H30A04.1
uniprot id: Q9NL29
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Highly expressed in the pharynx, circumpharyngeal cells, pharyngeal-intestinal valve and a subset of neurons in larval and embryonic stages. Also moderately expressed in the lining of the intestine, coelomocytes, labial process bundles and some hypodermal cells. In adults, it is predominantly expressed in the pharynx, the pharyngeal-intenstinal valve, some circumpharyngeal cells, m3, m4 and m6 pharyngeal muscles, and IL1, OLQ, BAG and ALN neurons. Weaker expression is observed in labial process bundles, coelomocytes, the ventral hypodermal ridge, the vulval hypodermis and the sensory rays of the adult male tail.
messages: Membrane
messages: Regulates pharyngeal pumping during feeding.
messages: Worms display a reduction in pharyngeal pumping rates, body length and intestine size, as well as a prolonged egg laying period and smaller brood size.

6239:CELE ZK131.9
gene id: 6239:CELE_ZK131.9
uniprot id: P04255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C18A11.7
gene id: 6239:CELE_C18A11.7
uniprot id: Q18066
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed throughout development from the 1.5 stage of embryogenesis in bodywall muscles.
messages: Stabilizes the attachment of the myofilament lattice to the muscle cell membrane. Isoform b is sufficient for wild-type function.
messages: The initiator methionine of isoform b is removed.

6239:CELE C26G2.1
gene id: 6239:CELE_C26G2.1
uniprot id: Q9U3P2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are viable, fertile, egg-laying proficient and coordinated. Abnormal synaptic vesicle clustering in the HSNL motor neuron from larval stage L3 through to adulthood. Reduced accumulation of synaptic vesicle proteins snb-1 and cat-1 in HSNL motor neuron. Defective synapse specificity due to altered distribution of synapses. syg-1 is mis-localized and diffusely distributed on the axon of the HSNL neuron.
messages: Cell adhesion protein (PubMed:15035988). Determines synapse formation (PubMed:15035988, PubMed:21858180, PubMed:24485456). Required for correct localization of syg-1 at synaptic sites (PubMed:15035988).
messages: Cell membrane
messages: Expressed in head neurons and body wall muscles during embryogenesis (PubMed:15035988). Expressed in head and body wall muscles and in punctate structures near the ventral nerve cord during larval stages L1 and L2 (PubMed:15035988). Expressed in primary vulval epithelial cells from larval stage L3, with expression increasing upon entry into L4 and diminished within six hours of adulthood (PubMed:15035988, PubMed:18675916).
messages: Expressed in vulval epithelial cells.
messages: Interacts with syg-1.
messages: Synapse
messages: The cytoplasmic domain is necessary for syg-2 subcellular localization.
messages: The first five extracellular Ig-like domains are required for correct localization of syg-1.

6239:CELE R107.2
gene id: 6239:CELE_R107.2
uniprot id: P32740
names: Function
names: Similarity
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

6239:CELE C25A1.5
gene id: 6239:CELE_C25A1.5
uniprot id: Q9XVS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F45E4.3
gene id: 6239:CELE_F45E4.3
uniprot id: W6RTA4
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the nervous system from the three-fold stage of embryonic development.
messages: Expressed in the nervous system.
messages: Produced by alternative promoter usage and alternative splicing.
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing.
messages: Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons (PubMed:29160205). The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:29160205). Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions (PubMed:29160205). Regulates synapse number in inhibitory motor neurons and plays a role in spontaneous postsynaptic synaptic vesicle release in muscle cells (PubMed:29160205).
messages: Synapse
messages: axon

6239:CELE F56F11.3
gene id: 6239:CELE_F56F11.3
uniprot id: Q9TZ64
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Expressed in all developmental stages, increasing gradually from embryo to larval L4 stage, decreasing and stabilizing in adult stage (PubMed:18680432). Expressed in intestine in all larval and adult stages, and in a few neuronal and hypodermal cells (PubMed:18680432).
messages: Expressed in intestine, hypodermis and a few neurons.
messages: Induced by treatment with high levels of paraquat, a chemical causing production of reactive oxygen species (ROS), but not by other exogenous stressors, such as heat shock or osmotic stress.
messages: Interacts with E3 ubiquitin-protein ligase wwp-1 (via WW domains).
messages: Nucleus
messages: RNAi-mediated knockown leads to increased cell death, perhaps by apoptosis, in the germline and uterus of hermaphrodites (PubMed:18680432). Lipid contents in the intestine increase (PubMed:18680432). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825). Abolishes lifespan extension on either isp-1;ctb-1 double mutant, or isp-1, gas-1 or mev-1 single mutant backgrounds; knockdown is most effective when applied in early adulthood, rather than during early development (PubMed:31346165). Further decreases the lower movement rates of isp-1;ctb-1 double mutants (PubMed:31346165).
messages: Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases (PubMed:18680432, PubMed:24805825, PubMed:31346165). Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner (PubMed:24805825, PubMed:31346165). Involved in the response to oxidative stress (PubMed:31346165). Plays a role in cell death (PubMed:18680432).
messages: Ubiquitinated; probably preferentially monoubiquitinated by wwp-1.

6239:CELE F21D12.1
gene id: 6239:CELE_F21D12.1
uniprot id: G5EBL9
uniprot id: H2KZU1
uniprot id: H2KZU2
uniprot id: H2KZU3
uniprot id: H2KZU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C05D11.5
gene id: 6239:CELE_C05D11.5
uniprot id: Q11185
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

6239:CELE C33A11.1
gene id: 6239:CELE_C33A11.1
uniprot id: G5EDE9
names: Function
names: Similarity
names: Tissue Specificity
messages: Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex.
messages: Belongs to the iASPP family.
messages: Expressed in the nervous system.

6239:CELE C27D6.8
gene id: 6239:CELE_C27D6.8
uniprot id: Q95ZY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed throughout the head.
messages: G-protein coupled receptor.
messages: Perikaryon
messages: dendrite

6239:CELE C01G12.8
gene id: 6239:CELE_C01G12.8
uniprot id: G5EFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

6239:CELE Y11D7A.3
gene id: 6239:CELE_Y11D7A.3
uniprot id: Q2A7S9
uniprot id: Q9XWR7
uniprot id: X5LXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE C32F10.6
gene id: 6239:CELE_C32F10.6
uniprot id: Q10902
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C18A3.3
gene id: 6239:CELE_C18A3.3
uniprot id: Q09958
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

6239:CELE C34G6.2
gene id: 6239:CELE_C34G6.2
uniprot id: O01497
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R05H5.6
gene id: 6239:CELE_R05H5.6
uniprot id: P54141
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed in the ADL, ADF and ASH chemosensory neurons in the head and in the PHA and PHB chemosensory neurons in the tail. Low expression also observed in the egg-laying structures in the mid-body region.
messages: Mediates recognition and avoidance of Streptomyces species by detecting dodecanoic acid secreted by the bacteria. Also mediates avoidance of decanoic acid which is not secreted by Streptomyces species but this may represent an additional important avoidance response in the environment.
messages: RNAi-mediated knockdown results in defective head and tail avoidance responses to Streptomyces and to dodecanoic acid. It also results in severely reduced calcium influx into ASH neurons in response to both S.avermitilis and dodecanoic acid.

6239:CELE F25H9.7
gene id: 6239:CELE_F25H9.7
uniprot id: E1B6U7
uniprot id: P91989
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

6239:CELE ZK455.2
gene id: 6239:CELE_ZK455.2
uniprot id: E7EAU8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in BAG sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of CO2 levels and acidity by the BAG neurons. May act as a direct receptor for CO2 and H+ (PubMed:21173231, PubMed:24240097).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium

6239:CELE F25B4.2
gene id: 6239:CELE_F25B4.2
uniprot id: Q22967
names: Similarity
messages: Belongs to the pellino family.

6239:CELE F15E6.6
gene id: 6239:CELE_F15E6.6
uniprot id: O61198
names: Cofactor
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.

6239:CELE Y47H9A.1
gene id: 6239:CELE_Y47H9A.1
uniprot id: G5EFH6
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE T07G12.5
gene id: 6239:CELE_T07G12.5
uniprot id: A0A061ACV1
uniprot id: B3GWD8
uniprot id: O18057
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T14B4.7
gene id: 6239:CELE_T14B4.7
uniprot id: P35800
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE Y71H2AM.20
gene id: 6239:CELE_Y71H2AM.20
uniprot id: Q9BL35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE K12H4.2
gene id: 6239:CELE_K12H4.2
uniprot id: P34523
names: Similarity
messages: Belongs to the Iojap/RsfS family.

6239:CELE Y73B6BL.34
gene id: 6239:CELE_Y73B6BL.34
uniprot id: Q8MXR1
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C06A6.4
gene id: 6239:CELE_C06A6.4
uniprot id: Q17686
uniprot id: Q5WRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

6239:CELE T28D9.10
gene id: 6239:CELE_T28D9.10
uniprot id: Q10013
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).
messages: cytosol

6239:CELE Y53F4B.39
gene id: 6239:CELE_Y53F4B.39
uniprot id: Q95Q18
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

6239:CELE F33D4.1
gene id: 6239:CELE_F33D4.1
uniprot id: Q9XYB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F48C5.1
gene id: 6239:CELE_F48C5.1
uniprot id: Q20559
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C27C12.4
gene id: 6239:CELE_C27C12.4
uniprot id: Q18251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE C34E10.8
gene id: 6239:CELE_C34E10.8
uniprot id: P46582
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Broadly expressed in neuronal, intestinal and in hypodermal cells, including hyp7 cells, throughout the larval stages and persisting into adulthood.
messages: Cytoplasm
messages: Nuclear factor that influences the activity of genes involved in vulval development.
messages: Nucleus
messages: axon

6239:CELE Y113G7B.24
gene id: 6239:CELE_Y113G7B.24
uniprot id: Q9U2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

6239:CELE Y48A6B.11
gene id: 6239:CELE_Y48A6B.11
uniprot id: G5EFV3
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with phosphatase regulatory subunit rsa-1 and tpxl-1 (PubMed:17218259). May interact with spd-5 (PubMed:17218259). May interact with sys-1 (PubMed:25819561).
messages: RNAi-mediated knockdown causes defects in spindle assembly characterized by kinetochore microtubule instability, a reduction in centrosomal microtubules and a decrease in outgrowth of microtubule plus ends from centrosomes (PubMed:17218259). Also causes a reduction of sys-1/beta-catenin enrichment at centrosomes throughout early embryonic cleavages (PubMed:25819561). Increases sys-1 nuclear accumulation without affecting sys-1 asymmetric distribution in E and MS blastomers (PubMed:25819561).
messages: Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes (PubMed:17218259). Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions (PubMed:25819561).
messages: centrosome

6239:CELE Y54G11A.11
gene id: 6239:CELE_Y54G11A.11
uniprot id: Q9XVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

6239:CELE F10D11.1
gene id: 6239:CELE_F10D11.1
uniprot id: P31161
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

6239:CELE M163.4
gene id: 6239:CELE_M163.4
uniprot id: Q93903
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed in gut cells and mature sperm stored in the spermatheca.
messages: Expressed in the developing germ line and throughout embryogenesis and the L1-L4 larval stages.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis.
messages: RNAi-mediated knockdown results in both viable and inviable embryos, but eventually animals display germline maintenance defects and become sterile (PubMed:11861581). Double RNAi-mediated knockdown and/or mutagenesis with such-1 results in increased embryonic lethality and the production of one-cell arrested embryos (PubMed:20944012).
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE C36H8.1
gene id: 6239:CELE_C36H8.1
uniprot id: Q18503
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE M03B6.2
gene id: 6239:CELE_M03B6.2
uniprot id: Q93896
names: Subcellular Location Annotation
messages: Membrane

6239:CELE M01A10.2
gene id: 6239:CELE_M01A10.2
uniprot id: A0A0K3AR90
uniprot id: A0A0K3ATN9
uniprot id: A0A0K3AWL6
uniprot id: G5EE26
uniprot id: Q14DX2
uniprot id: Q49HI3
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

6239:CELE Y47D7A.14
gene id: 6239:CELE_Y47D7A.14
uniprot id: A0A168HBC9
uniprot id: A0A168HBE9
uniprot id: G4SDH4
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Down-regulated by high levels of riboflavin.
messages: Expressed in embryos, larvae and adults.
messages: Expressed in intestine and pharynx.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
messages: RNAi-mediated knockdown causes a severe reduction in the number of laid eggs.
messages: Riboflavin transporter.

6239:CELE Y37D8A.22
gene id: 6239:CELE_Y37D8A.22
uniprot id: Q9XWU8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the VMP1 family.
messages: Cytoplasm
messages: Defective P granule organization and degradation (PubMed:20550938). Early autophagic structures and lgg-1 puncta form an irregular shape and clump together (PubMed:20550938). RNAi-mediated knockdown results in increased lgg-2-positive autophagosomes following fertilization and at later embryonic stages (PubMed:24374177).
messages: Expressed in pharyngeal and body wall muscles and intestine cells.
messages: Involved in autophagy (PubMed:20550938, PubMed:24374177). Thought to act in autophagasome and omegasome formation (PubMed:20550938).
messages: Membrane
messages: Ubiquitously expressed during embryogenesis.

6239:CELE R06C1.3
gene id: 6239:CELE_R06C1.3
uniprot id: F5GUF0
uniprot id: Q9XVK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

6239:CELE F22D6.4
gene id: 6239:CELE_F22D6.4
uniprot id: Q19724
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
messages: Mitochondrion inner membrane

6239:KEF34 p12
gene id: 6239:KEF34_p12
uniprot id: P24885
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

6239:CELE F35H10.5
gene id: 6239:CELE_F35H10.5
uniprot id: Q20071
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

6239:CELE H13N06.3
gene id: 6239:CELE_H13N06.3
uniprot id: Q9XTQ5
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the gob-1 trehalose phosphatase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.
messages: Expression first seen at the 8E cell stage in the embryonic intestine. Expression continues to and includes adulthood. Beginning at the comma stage, additional expression is seen in the head and possibly in the hypodermis. By the twofold stage and continuing into adulthood, expression becomes increasingly widespread, with strong staining in the intestine, pharynx, hypodermis, body wall muscle, tail, and unidentified head neurons.
messages: Lethal at early larval stage. Mutant larvae show intestinal defects, and a high proportion exhibit gut obstruction (gob). No visible phenotype when gob-1 is down-regulated together with the trehalose phosphate synthases tps-1 and tps-2.
messages: Ubiquitously expressed. Strong expression in intestine.

6239:CELE H23L24.3
gene id: 6239:CELE_H23L24.3
uniprot id: H2KZM9
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Expressed in amphid sensory neurons (PubMed:20519502, PubMed:29129530). Weakly expressed in body wall muscles (PubMed:20519502). Isoform a: Specifically expressed in ciliated sensory neurons in the head, including the IL1s, OLQ, head CEP, and amphid neurons. In the male tail, expressed in HOA, RnA, and phasmid neurons (PubMed:29129530). Isoform b: Specifically expressed in male and hermaphrodite IL2 ciliated sensory neurons, and in male-specific CEM, HOB and RnB ciliated sensory neurons (PubMed:29129530).
messages: Expressed in embryos and adults.
messages: Extracellular vesicle
messages: Perikaryon
messages: Polyglutamylase which preferentially modifies tubulin (PubMed:29129530, PubMed:27635036). Involved in the side-chain initiation step of the polyglutamylation reaction (PubMed:29129530, PubMed:27635036). By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia (PubMed:29129530). Together with ttll-4 and 5, required for male mating (PubMed:27635036).
messages: Specifically promotes tubulin glutamylation in a subset of ciliated neurons including amphid, phasmid, CEP and RnA neurons.
messages: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles (PubMed:29129530). Regulates the localization of TRP channel pdk-2 in male CEM, HOB and RnB neurons (PubMed:29129530). Regulates the environmental release of bioactive extracellular vesicles in cilia (PubMed:29129530).
messages: axon
messages: cilium
messages: dendrite

6239:CELE Y71H2B.10
gene id: 6239:CELE_Y71H2B.10
uniprot id: Q9N4F3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

6239:CELE C23G10.7
gene id: 6239:CELE_C23G10.7
uniprot id: Q45EK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

6239:CELE T18H9.6
gene id: 6239:CELE_T18H9.6
uniprot id: Q22550
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 27 family.
messages: Nucleus

6239:CELE T19A5.5
gene id: 6239:CELE_T19A5.5
uniprot id: A0A131MCX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C33F10.5
gene id: 6239:CELE_C33F10.5
uniprot id: H2KZ60
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the immunoglobulin superfamily. Contactin family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in neurons including the I1 and I3 pharyngeal interneurons, NSM and VNC motor neurons, HSN and CAN neurons, the ALM and PLM touch receptor neurons and other unidentified head neurons (PubMed:23123963). Expressed in AVG interneurons (PubMed:28901288). Also expressed in somatic muscles, the excretory canal, the excretory cell and the hypodermis (PubMed:23123963).
messages: Expressed throughout embryonic development and adulthood.
messages: Interacts with sax-7; the interaction establishes synaptic connections between neurons.
messages: Perikaryon
messages: Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation (PubMed:23123963). By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons (PubMed:28901288). Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis (PubMed:23123963). Plays a role in regulating male mating behavior (PubMed:28901288).
messages: RNAi-mediated knockdown results in truncated or shorter excretory canals, and also truncated ALM axons that fail to extend above the nerve ring, truncated PLM processes and abnormal VNC axon patterning.
messages: Synapse
messages: axon

6239:CELE C09G9.4
gene id: 6239:CELE_C09G9.4
uniprot id: Q17874
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE F40F11.2
gene id: 6239:CELE_F40F11.2
uniprot id: A6ZJ71
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: During gonad development, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody which allows for the formation of gonad arms. Role in gonad DTC migration may be in association with integrin related proteins ina-1 and mig-15.
messages: Embryonic lethal. RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis. RNAi-mediated knockdown specifically in gonad DTCs also result in a DTC migration defect in which DTCs migrate away from the hermaphrodite midbody on the dorsal basement membrane. RNAi-mediated knockdown in a unc-6 mutant background results in failed gonad DTC migration to the midbody of the hermaphrodite. RNAi-mediated knockdown with ina-1, mig-15 or talin in an rrf-3 mutant background results in enhanced gonad DTC migration.
messages: Expressed in gonad distal tip cells and gonad sheath cells.
messages: Expressed in somatic gonad precursors Z1 and Z4 in the gonad primordium and later in distal tip cells during the larval stages.
messages: Nucleus

6239:CELE F54H5.3
gene id: 6239:CELE_F54H5.3
uniprot id: P91330
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y55F3C.3
gene id: 6239:CELE_Y55F3C.3
uniprot id: Q95XV8
uniprot id: U4PAX5
uniprot id: U4PBB7
uniprot id: U4PE60
uniprot id: U4PLR3
uniprot id: U4PR20
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C41G6.2
gene id: 6239:CELE_C41G6.2
uniprot id: G5EEY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y38C1AA.11
gene id: 6239:CELE_Y38C1AA.11
uniprot id: Q8MXT1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

6239:CELE K07B1.1
gene id: 6239:CELE_K07B1.1
uniprot id: O01887
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase S1 family.
messages: Expressed in male L4 larvae and adults.
messages: In the male gonad, probably maintained inactive by swm-1.
messages: Secreted
messages: Serine protease which, in males, acts as a promoting signal during mating to activate sperm.
messages: Specifically expressed in the male gonad including the seminal vesicle, the valve region and the vas deferens.
messages: secretory vesicle lumen

6239:CELE F20A1.7
gene id: 6239:CELE_F20A1.7
uniprot id: H2KZ66
uniprot id: Q304E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE T20G5.10
gene id: 6239:CELE_T20G5.10
uniprot id: Q22616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BLOC1S1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1. Interacts with glo-2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in gut granule biogenesis. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: cytosol

6239:CELE C06G4.5
gene id: 6239:CELE_C06G4.5
uniprot id: P34311
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Putative receptor.

6239:CELE C08A9.3
gene id: 6239:CELE_C08A9.3
uniprot id: D1MN44
uniprot id: H2KYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

6239:CELE F54E4.4
gene id: 6239:CELE_F54E4.4
uniprot id: Q93787
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C10F3.6
gene id: 6239:CELE_C10F3.6
uniprot id: G5EFE7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 23 family.
messages: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (PubMed:15604090). The addition is prevented if the GlcNAc residue is already fucosylated (PubMed:15604090). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds (PubMed:20062796).
messages: Golgi stack membrane
messages: Inhibited by Fe(3+), Ni(2+) and Cu(2+).
messages: May also use Ca(2+). The enzyme has substantial activity without divalent cations.

6239:CELE C47E8.7
gene id: 6239:CELE_C47E8.7
uniprot id: Q18685
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the kindlin family.
messages: Cell membrane
messages: Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611). Probable regulator of cell-extracellular matrix adhesion (PubMed:10893272). Required during initial muscle assembly to form dense bodies and M-lines (PubMed:10893272).
messages: Interacts with pat-4/ILK (PubMed:12015115, PubMed:12781130). Probably forms a complex with pat-4 and pat-6 (PubMed:12781130). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: M line
messages: Mainly expressed in muscle cells in both embryos and adults.
messages: RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle. This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization.
messages: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.

6239:CELE Y19D10A.15
gene id: 6239:CELE_Y19D10A.15
uniprot id: G5EFQ7
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F57B10.7
gene id: 6239:CELE_F57B10.7
uniprot id: G5EC40
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

6239:CELE C34B7.4
gene id: 6239:CELE_C34B7.4
uniprot id: Q95ZX6
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

6239:CELE ZK682.2
gene id: 6239:CELE_ZK682.2
uniprot id: Q23576
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T09A5.7
gene id: 6239:CELE_T09A5.7
uniprot id: P45967
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

6239:CELE T10E10.7
gene id: 6239:CELE_T10E10.7
uniprot id: Q86NE2
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y47G6A.18
gene id: 6239:CELE_Y47G6A.18
uniprot id: Q9N3S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Membrane

6239:CELE T20D3.8
gene id: 6239:CELE_T20D3.8
uniprot id: O01259
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

6239:CELE CC4.3
gene id: 6239:CELE_CC4.3
uniprot id: G5EEG7
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat SMU1 family.
messages: Component of the spliceosome B complex (By similarity). Homodimer (via LisH domain) (PubMed:27150041). The homodimer interacts (via the N-terminal region including the LisH and CTLH domains) with smu-2, giving rise to a heterotetramer (PubMed:15254247, PubMed:27150041).
messages: Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247). Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site (PubMed:11438655, PubMed:15254247). In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18 (PubMed:11438655).
messages: Nucleus
messages: The WD repeats assemble into a seven-bladed WD propeller.
messages: Ubiquitous. Detected in the intestine and germline in adult hermaphrodites.
messages: Ubiquitous. Detected throughout embryonic and larval development and in adult hermaphrodites.

6239:CELE F41G3.12
gene id: 6239:CELE_F41G3.12
uniprot id: G5EG68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y43D4A.1
gene id: 6239:CELE_Y43D4A.1
uniprot id: Q9NF30
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C11G6.2
gene id: 6239:CELE_C11G6.2
uniprot id: Q17908
names: Similarity
messages: Belongs to the helicase family.

6239:CELE Y105C5A.24
gene id: 6239:CELE_Y105C5A.24
uniprot id: Q9NF64
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

6239:CELE T22H9.4
gene id: 6239:CELE_T22H9.4
uniprot id: Q9TXN8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE M04D8.1
gene id: 6239:CELE_M04D8.1
uniprot id: Q21507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE T23G11.3
gene id: 6239:CELE_T23G11.3
uniprot id: Q17339
names: Domain
names: Function
names: PTM
names: Subunit
names: Tissue Specificity
messages: Expressed in proximal and distal oocytes in female worms but is eliminated from proximal oocytes following mating.
messages: Homodimer.
messages: Phosphorylated by cdk-2 which may negatively regulate its expression in distal mitotic germline cells.
messages: RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence (PubMed:24838563). Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA (PubMed:11562350). Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA (PubMed:19758560). Binds sequences in the 3'-UTR region of tra-2 mRNA (PubMed:24838563). Germ line-specific tumor suppressor essential for oogenesis (PubMed:7601353). Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline (PubMed:7601353, PubMed:11562350, PubMed:24838563). Represses translation of the vacuolar ATPase component vha-13 in the distal gonad (PubMed:29168500). Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation (PubMed:11562350). By regulating cye-1 expression, prevents entry into mitosis in meiotic germline cells (PubMed:19758560, PubMed:21455289).
messages: The KH domain and the Qua2 region are involved in RNA binding.
messages: Undergoes proteasomal degradation in proximal oocytes following mating.

6239:CELE T10E9.7
gene id: 6239:CELE_T10E9.7
uniprot id: Q86NC2
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

6239:CELE T13F2.10
gene id: 6239:CELE_T13F2.10
uniprot id: Q9TVW5
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE B0334.1
gene id: 6239:CELE_B0334.1
uniprot id: Q17473
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F13C5.5
gene id: 6239:CELE_F13C5.5
uniprot id: O76565
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F52E4.7
gene id: 6239:CELE_F52E4.7
uniprot id: Q20678
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC3 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE F44C8.5
gene id: 6239:CELE_F44C8.5
uniprot id: H2L017
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE W01A11.2
gene id: 6239:CELE_W01A11.2
uniprot id: Q23067
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y47D3A.30
gene id: 6239:CELE_Y47D3A.30
uniprot id: F3Y5R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

6239:CELE C07G3.9
gene id: 6239:CELE_C07G3.9
uniprot id: A0A131MBT3
uniprot id: O16322
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK84.3
gene id: 6239:CELE_ZK84.3
uniprot id: P56173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE B0350.2
gene id: 6239:CELE_B0350.2
uniprot id: Q5TYL5
uniprot id: Q5TYL6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y57A10C.6
gene id: 6239:CELE_Y57A10C.6
uniprot id: G5EDP2
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA (PubMed:9151950). Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone (PubMed:19496754, PubMed:19174521).
messages: Expressed in all larval stages with levels peaking at the L3 larval stage and decreasing in the adult.
messages: Expressed in intestine, hypodermis and body-wall muscle.
messages: In short-term culture, loss of the capacity to enter the dauer stage which is associated with a loss in the production of the dauer pheromone. In long-term culture, the capacity to induce the dauer stage is restored and is associated with the accumulation of long fatty acid chain ascarosides (PubMed:19174521). Intestinal expression of daf-22 restores the production of the pheromone (PubMed:19174521). Partial dauer phenotype in only half of mutants when the dauer pheromone is added exogenously (PubMed:19496754). In addition, mutants accumulate large fat granules in the intestine, have a decreased growth rate resulting in smaller adults and have a substantial reduction in brood size (PubMed:19496754).
messages: Inhibited by acetyl-CoA.
messages: Peroxisome

6239:CELE C48C5.1
gene id: 6239:CELE_C48C5.1
uniprot id: Q18701
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F55A4.7
gene id: 6239:CELE_F55A4.7
uniprot id: Q94242
names: Similarity
messages: Belongs to the calponin family.

6239:CELE F44G3.9
gene id: 6239:CELE_F44G3.9
uniprot id: O45521
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C04C3.2
gene id: 6239:CELE_C04C3.2
uniprot id: O44452
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C34F6.3
gene id: 6239:CELE_C34F6.3
uniprot id: O17642
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C09H10.3
gene id: 6239:CELE_C09H10.3
uniprot id: Q17880
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

6239:CELE F25G6.7
gene id: 6239:CELE_F25G6.7
uniprot id: H2KYN8
uniprot id: Q6A592
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC239.4
gene id: 6239:CELE_ZC239.4
uniprot id: P91558
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE C27B7.4
gene id: 6239:CELE_C27B7.4
uniprot id: Q18241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

6239:CELE F53G2.7
gene id: 6239:CELE_F53G2.7
uniprot id: O17245
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

6239:CELE W03C9.4
gene id: 6239:CELE_W03C9.4
uniprot id: G5EGB2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in all larval stages, increasing in level from L1 to L4 and then diminishing in younger and older adults (PubMed:7671813). Expressed in hermaphrodite lateral hypodermal seam cells during the larval L3- to L4-molt stage and into adulthood (at protein level) (PubMed:8756296). Expressed in the hypodermal cells of the head (hyp1-hyp6), tail (hyp8-hyp12), and the large hypodermal syncytium covering most of the animal (hyp7) (at protein level) (PubMed:8756296, PubMed:27401555). Also expressed in some non-hypodermal cells during stages L2 to L4 (at protein level) (PubMed:8756296, PubMed:9334281). Expressed in the anchor cell beginning at the L2 molt or early L3 stage (PubMed:9334281). Male-specific expression in the linker cell (LC), positioned at the tip of the growing end of the gonad at stage L3 (at protein level). Male-specific expression in ventral cord neurons from late L3 stage (at protein level) (PubMed:9986728).
messages: Expressed in all larval stages, increasing in level from L2 to L4 and then diminishing in younger and older adults (PubMed:7671813). Expressed at low level in lateral seam cells in larval L3 stage and up-regulated during L4, including in the major hypodermal syncytium hyp7 (PubMed:32223899).
messages: Expressed in lateral hypodermal seam cells (at protein level).
messages: Interacts (via C-terminus) with transcription cofactor mab-10.
messages: Nucleus
messages: RNAi-mediated knockdown abolished expression of collagen col-38 at mid-to-late larval stage L4 (PubMed:29604168). Knockdown, whether untargeted, or hypodermis-specific, represses intestinal genes involved in fatty acid metabolism and beta-oxidation in the L4 larval stage (PubMed:31974205). Drastically reduces expression of the vitellogenin genes (PubMed:27401555). Knockdown causes transcription factor pqm-1 to accumulate in the intestinal nuclei at adulthood, but has no effect on daf-16 localization (PubMed:27401555).
messages: Required for seam cell fusion.
messages: Transcription factor which regulates the expression of various genes, including those involved in cuticle synthesis and maintenance, such as collagens, and in lipid metabolism (PubMed:7671813, PubMed:29604168, PubMed:31974205, PubMed:27401555). Binds to promoter regions of genes, at 5'-[(T/G)TTTTTT(A/T/C/G)]-3' consensus sequences (PubMed:29604168, PubMed:25905672). Heterochronic protein which controls the choice of stage specific cell fates, including at the juvenile to adult transition (PubMed:7671813, PubMed:32223899). Promotes differentiation, together with transcriptional cofactor mab-10, perhaps as part of a transcriptional complex (PubMed:21862562). Required for vulval morphogenesis and egg laying; perhaps by acting in a subset of the lateral seam cells (PubMed:9334281). Involved in the exit of seam cells from the cell cycle (PubMed:32223899). Required for specification of uterine pi-cell fate, acting upstream of lin-12 Notch signaling, perhaps via maintenance of lag-2 expression in the anchor cell (AC) (PubMed:11114514). Involved in morphogenesis of the specialized male tail used in mating (PubMed:9986728). Acts cell non-autonomously from the hypodermis to regulate expression of genes in the intestine, including genes involved in lipid metabolism (PubMed:31974205, PubMed:27401555). May regulate vitellogenesis via the mTORC2 signaling mediated pathway, independently of daf-16 (PubMed:27401555). May promote nuclear accumulation of mab-10 in seam cells post-transcriptionally (PubMed:21862562). Dispensable for seam cell fusion (PubMed:32223899).

6239:CELE ZK1128.4
gene id: 6239:CELE_ZK1128.4
uniprot id: Q09645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

6239:CELE C53A5.17
gene id: 6239:CELE_C53A5.17
uniprot id: A8WHT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

6239:CELE C27H6.2
gene id: 6239:CELE_C27H6.2
uniprot id: O17607
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Expressed in gonadal cells.
messages: Expressed in most cells of the early embryo. From the two-cell stage until late embryogenesis, expression is restricted to pharyngeal cells. Detected in two intestinal cells during the larval stage.
messages: Forms homohexameric rings. May form a dodecamer with ruvb-2 made of two stacked hexameric rings.
messages: Nucleus
messages: Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce-Tor signaling pathway whereby it is required for the accumulation and localization of box C/D snoRNP to nucleoli to regulate ribosomal maturation and thus protein synthesis (PubMed:18804378). Antagonizes the transcriptional activity of transcription factor pha-4, to control postembryonic development and adult longevity (PubMed:17720918, PubMed:18804378). Has a role in pharyngeal development (PubMed:17720918). Has a role in gonadal development (PubMed:25437307).
messages: RNAi-mediated knockdown results in arrest at larval stage L3, with less than 40% forming a mature vulva, lipid accumulation, epidermal granule formation and reduced protein synthesis (PubMed:17720918, PubMed:18804378). There is also gonadal detachment during gonad migration (PubMed:25437307).

6239:CELE ZK849.4
gene id: 6239:CELE_ZK849.4
uniprot id: O18303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE C06E1.8
gene id: 6239:CELE_C06E1.8
uniprot id: P34303
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K10B4.4
gene id: 6239:CELE_K10B4.4
uniprot id: O17239
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE K08F4.4
gene id: 6239:CELE_K08F4.4
uniprot id: Q21353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

6239:CELE R12H7.5
gene id: 6239:CELE_R12H7.5
uniprot id: G5EE98
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE K08E7.3
gene id: 6239:CELE_K08E7.3
uniprot id: Q21341
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Required for the proper orientation of spindles after the establishment of polarity (PubMed:9477332, PubMed:14534135). May play a role in interactions between the astral microtubules and the cortical cytoskeleton (PubMed:9477332). Required for asymmetric forces on nuclei and spindles (PubMed:9477332). Acts downstream of the PAR signaling as an intermediate that transduces polarity information to the machinery that positions the mitotic spindle, possibly by regulating force generation (PubMed:12223405). Regulates gpr-1/2 asymmetric cortical localization during the first embryonic cell divisions (PubMed:14534135). Acts antagonistically to the gpr-1/2 signaling pathway (PubMed:14534135). Regulates mes-1 expression and/or localization pattern during early embryogenesis (PubMed:11003841).
messages: cell cortex

6239:CELE K10C2.3
gene id: 6239:CELE_K10C2.3
uniprot id: Q94271
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE T02B11.6
gene id: 6239:CELE_T02B11.6
uniprot id: O16976
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y49E10.15
gene id: 6239:CELE_Y49E10.15
uniprot id: Q9XTU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: cytosol

6239:CELE H32C10.3
gene id: 6239:CELE_H32C10.3
uniprot id: Q9TYQ6
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE ZK354.4
gene id: 6239:CELE_ZK354.4
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C27F2.10
gene id: 6239:CELE_C27F2.10
uniprot id: Q95QU0
names: Similarity
messages: Belongs to the CSN12 family.

6239:CELE F57B10.9
gene id: 6239:CELE_F57B10.9
uniprot id: O44735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

6239:CELE F36A4.14
gene id: 6239:CELE_F36A4.14
uniprot id: Q20097
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T13H5.6
gene id: 6239:CELE_T13H5.6
uniprot id: Q9U369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

6239:CELE Y80D3A.2
gene id: 6239:CELE_Y80D3A.2
uniprot id: Q9U1Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWF11 family.
messages: Nucleus

6239:CELE K12D9.4
gene id: 6239:CELE_K12D9.4
uniprot id: P91379
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y55D5A.5
gene id: 6239:CELE_Y55D5A.5
uniprot id: A0A0K3ARZ1
uniprot id: A0A0K3AUY1
uniprot id: A0A0K3AXA0
uniprot id: Q968Y9
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accumulation of fat, pigmented intestine, increased lifespan, increased dauer formation and increased resistance to pathogens. Severe loss of function mutants display recessive early embryonic lethality (PubMed:9252323, PubMed:9790527, PubMed:11274053, PubMed:18782349, PubMed:18245374). RNAi-mediated knockdown in germline, hypodermis, intestine or in muscles causes increased lifespan (PubMed:24332851, PubMed:28853436). RNAi-mediated knockdown in a ncl-1 mutant (e1942) background reduces the increased longevity of the daf-2 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436). RNAi-mediated knockdown in adults causes an increase in lgg-1 positive autophagic vesicles (PubMed:22560223). RNAi-mediated knockdown results in an increase in the number of muscle arm extensions (PubMed:18436204). RNAi-mediated knockdown together with tatn-1 RNAi extends the lifespan of the single daf-2 RNAi mutant (PubMed:24385923).
messages: Autophosphorylation activates the kinase activity (By similarity). Interaction with shc-1 may inhibit its activity (PubMed:18832074).
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage (PubMed:9252323, PubMed:9790527, PubMed:11743719, PubMed:24332851, PubMed:28853436, PubMed:21334311, PubMed:29500338, PubMed:24385923). Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1 (PubMed:11274053). Required for germline progenitor proliferation during larval development (PubMed:22278922). Required for the response to environmental stimuli such as light, food, pheromone, and temperature (PubMed:24332851, PubMed:29500338). Negatively regulates resistance to UV and oxidative stress (PubMed:24332851). In a daf-16/FOXO-dependent manner, plays a role in regulating the response to white light (PubMed:29500338). Role in immune function and pathogen resistance (PubMed:18782349). Negatively regulates autophagy (PubMed:22560223). Regulates daf-18/PTEN protein levels (PubMed:23995781). Plays a role in controlling seam cell development during the larval stages (PubMed:21471153).
messages: Membrane
messages: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity). Interacts (via cytoplasmic domain) with shc-1 (PID domain) (PubMed:18832074). Interacts (via kinase domain) with daf-18 (via C-terminus) (PubMed:23995781).

6239:CELE F10B5.1
gene id: 6239:CELE_F10B5.1
uniprot id: Q09533
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (By similarity).

6239:CELE C04E12.5
gene id: 6239:CELE_C04E12.5
uniprot id: A0A131MBK3
uniprot id: O76676
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE F47H4.10
gene id: 6239:CELE_F47H4.10
uniprot id: Q9XU27
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE C39E6.6
gene id: 6239:CELE_C39E6.6
uniprot id: Q18534
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Expressed in neurons, including neurons in the head, the ventral nerve cord, and the preanal ganglion.
messages: G-protein coupled receptor for FARP(FMRFamide related peptide) neuropeptides (PubMed:12821653, PubMed:14555955). Activated by FARP neuropeptides flp-18 and flp-21 (PubMed:12821653, PubMed:14555955). Plays a role in modulating social and feeding behavior (PubMed:9741632). Required to modulate locomotion quiescence during the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity (PubMed:23764289, PubMed:27585848).
messages: It has been reported that many phenotypes associated with the Bristol N2 reference allele of npr-1 may reflect a neomorphic gain-of-function sensitivity of the receptor to flp-18 in addition to sensitivity to flp-21.
messages: Membrane

6239:CELE M05D6.2
gene id: 6239:CELE_M05D6.2
uniprot id: G5ECL1
names: Similarity
messages: Belongs to the TCP11 family.

6239:CELE R04F11.2
gene id: 6239:CELE_R04F11.2
uniprot id: Q21732
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

6239:CELE JC8.10
gene id: 6239:CELE_JC8.10
uniprot id: G5ECL2
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis.
messages: Synapse
messages: The Pro-rich domain is dispensable for endocytosis during the synaptic vesicle recycling, locomotion and for endogenous and evoked excitatory postsynaptic currents (EPSC) at neuromuscular junctions (PubMed:21029864, PubMed:25918845). May play a role together with the SAC domain in targeting unc-26 to synapses (PubMed:25918845).
messages: The SAC domain, but not is catalytic activity, is required for targeting unc-26 to synapses, for locomotion and for normal endogenous and evoked excitatory postsynaptic currents (EPSC) at neuromuscular junctions.
messages: Viable but small with slow grow and uncoordinated movements (PubMed:10931870, PubMed:21029864). Synaptic vesicles at neuromuscular synapses are reduced, arranged linearly and are dissociated from the synaptic active zone (PubMed:10931870). Several defects in vesicle recycling including accumulation of endocytic pits at the neuromuscular junctions and accumulation of coated vesicles predominantly at synapses of neurons but also near the Golgi in cell bodies of neurons, muscles, hypodermis and gonadal sheath cells (PubMed:10931870). Accumulation of endosome-like compartments in cholinergic and GABA neurons and diffused snb-1/synaptobrevin distribution along the ventral nerve cord (PubMed:10931870). Neurotransmission defects characterized by reduced endogenous frequency of synaptic vesicle fusion, a reduced evoked current amplitude after one stimulation and a faster decline in evoked response caused by multiple responses (PubMed:14622579). Resistant to paralysis induced by Aldicar, an acetylcholinesterase inhibitor which causes acetylcholine accumulation (PubMed:14622579).
messages: synaptic vesicle

6239:CELE H27D07.4
gene id: 6239:CELE_H27D07.4
uniprot id: O61910
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T27F2.1
gene id: 6239:CELE_T27F2.1
uniprot id: Q22836
names: Similarity
messages: Belongs to the SNW family.

6239:CELE AH9.1
gene id: 6239:CELE_AH9.1
uniprot id: Q10904
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Not known. Putative receptor.

6239:CELE C53B7.4
gene id: 6239:CELE_C53B7.4
uniprot id: Q18803
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase g subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE T22E7.2
gene id: 6239:CELE_T22E7.2
uniprot id: Q9N5D8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F27C1.6
gene id: 6239:CELE_F27C1.6
uniprot id: P91280
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

6239:CELE ZK945.2
gene id: 6239:CELE_ZK945.2
uniprot id: Q09583
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE H19N07.4
gene id: 6239:CELE_H19N07.4
uniprot id: F1LIN4
uniprot id: Q9NCE1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

6239:CELE F46C5.3
gene id: 6239:CELE_F46C5.3
uniprot id: Q20459
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal muscles, pharyngeal-intestinal valve, rectal gland cells and arcade cells.
messages: Metalloprotease.
messages: Secreted

6239:CELE C44B11.3
gene id: 6239:CELE_C44B11.3
uniprot id: P91910
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Specifically expressed in neurons.
messages: Touch insensitive phenotype, which may be due to defective touch receptor neuron synaptic transmission.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Component of the large-diameter neuronal microtubules which contains 15 protofilaments (PubMed:9885292). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:9885292, PubMed:19652181).
messages: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.

6239:CELE R13H8.1
gene id: 6239:CELE_R13H8.1
uniprot id: O16850
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Dauer defective phenotype in larvae and a reduced stress phenotype in adults (PubMed:9360933). Increased carbonyl accumulation and increased sensitivity to starvation (PubMed:18025456). Increased expression of the srh-234 chemoreceptor during starvation (PubMed:25357003). Increased sensitivity to physical injury and more susceptible to death by nematophagous fungal infection (PubMed:24146615). Increased lifespan (PubMed:23805378). Causes a delay in apoptosis during embryonic development (PubMed:25383666). Defective gustatory associative learning in response to salt cues (PubMed:30779740). RNAi-mediated knock-down reduces expression of daf-16 target genes and genes up-regulated in response to nematophagous fungal infection such as sod-3 (PubMed:24146615). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:17900900). Simultaneous RNAi-mediated knockdown of metalloproteinase zmp-2 restores normal survival upon heat stress and prevents increased susceptibility to heat stress in a daf-9 or daf-12 mutant background (PubMed:24957743). RNAi-mediated knockdown in a daf-2 (e1370) mutant background restores expression of deubiquitinase ubh-4 in the intestine (PubMed:23770237). RNAi-mediated knockdown suppresses the decreased number of mitotic nuclei in the germline of developing larvae in an atg-18 (gk378) or atg-16.2 (ok3224) mutant background. Suppresses associative memory, axon regeneration and fkh-9 transcript levels, in a daf-2 mutant background. RNAi-mediated knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229).
messages: Expressed in embryos, larvae, dauer larvae and adults.
messages: Expression increases substantially with age.
messages: Expression throughout the body increases slightly with age.
messages: Forkhead-type transcription factor (PubMed:9360933). Binds to the promoters of genes that contain the daf-16/FOXO binding element (DBE), TTGTTTAC, in their regulatory region (PubMed:10880363, PubMed:23770237, PubMed:26675724). Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, sleep, associative memory, and dauer formation (PubMed:9360933, PubMed:8247153, PubMed:11747821, PubMed:11747825, PubMed:11381260, PubMed:14622602, PubMed:12750521, PubMed:17900900, PubMed:18358814, PubMed:18762027, PubMed:18832074, PubMed:19103192, PubMed:21531333, PubMed:22081913, PubMed:29523076, PubMed:26675724). Longevity signaling predominantly arises from expression in the intestine (PubMed:14622602). Transcriptional activity of daf-16/FOXO is negatively regulated by interaction with host cell factor homolog hcf-1; and by cytoplasmic sequestration by association with ftt-2 (PubMed:11381260, PubMed:21531333, PubMed:18828672). Inhibition is required for the carbon dioxide (CO2) avoidance response (PubMed:18524954). Upon loss of inhibition, daf-16 translocates to the nucleus to regulate genes that result in delayed reproduction and growth while increasing stress resistance starvation tolerance and longevity (PubMed:11747825, PubMed:21531333). Association with arginine methyltransferase prmt-1 prevents phosphorylation and allows for translocation to the nucleus and the subsequent transcription of longevity-related genes (PubMed:21531333). Modulation of its activity by cGMP levels in sensory neurons regulates lifespan (PubMed:19489741). Has a protective role against muscle dystrophy (PubMed:18397876). Involved in mediating protection against aberrant protein aggregation proteotoxicity (PubMed:16902091). Influences transcription of genes that code for proteins involved in immunity as part of a general stress response (PubMed:17096597, PubMed:18245330). Targets genes that inhi…
messages: Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345). May play a role in lifespan modulation, but less significant than that played by isoforms d and f (PubMed:24834345).
messages: Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345). Transcript level in the early adult may play a role in lifespan modulation, but effect is more significant than that played by isoform a (PubMed:24834345).
messages: Induced by quinic acid.
messages: Interacts with rle-1 (PubMed:17276341). Interacts with unc-43 and tax-6 (PubMed:23805378). Interacts with jnk-1 (PubMed:15767565). Interacts with ftt-2 (PubMed:16777605, PubMed:21531333). Interacts with prmt-1 (PubMed:21531333). Interacts with hcf-1.
messages: Isoform b and isoform c are expressed in ectoderm, muscles, intestine and neurons (PubMed:9353126, PubMed:11747825, PubMed:14622602, PubMed:17894411). Isoform b is also expressed in the pharynx (PubMed:11747821). The intestine appears to be the primary site of longevity function (PubMed:14622602).
messages: Methylation by prmt-1 prevents phosphorylation and promotes translocation to the nucleus to allow for daf-16-dependent transcription.
messages: Nucleus
messages: Phosphorylated by akt-1 and/or akt-2 (PubMed:18358814, PubMed:21531333). Phosphorylated by sgk-1 (PubMed:18358814). Phosphorylated by unc-43 (PubMed:23805378). Phosphorylated by jnk-1 (PubMed:15767565). Dephosphorylated by tax-6 in vitro (PubMed:23805378).
messages: Ubiquitinated. Ubiquitination by rle-1 leads to proteasome-mediated degradation.

6239:CELE K10B4.3
gene id: 6239:CELE_K10B4.3
uniprot id: O17237
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MELT/VEPH family.
messages: Cell membrane
messages: The PH domain is required for membrane targeting.

6239:CELE T22G5.2
gene id: 6239:CELE_T22G5.2
uniprot id: O02323
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE W09C2.1
gene id: 6239:CELE_W09C2.1
uniprot id: H9G2S7
uniprot id: P28515
uniprot id: Q3S1J8
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Both zinc fingers are required for DNA binding in vitro.
messages: Expressed from the 28 cell stage of embryogenesis in hypodermal and muscle precursor cells (at protein level) (PubMed:9224715). Expressed from the 20-30 cell stage of embryogenesis onwards (PubMed:16303852). At the beginning of the comma stage, expression decreases in the dorsal and ventral hypodermis, but remains high in the seam cells until the pretzel stage of embryogenesis (PubMed:16303852). Expressed in neuronal cells of the retrovesicular ganglion during the threefold stage of embryogenesis (PubMed:16303852). Expressed highly in seam cells and retrovesicular ganglion and ventral cord neuronal cells from the L1 stage of larval development to adult (PubMed:16303852). Expressed in the sperm-producing germ line in spermatogenesis during the L4 stage of larval development (PubMed:19591818).
messages: Expressed in ventral cord and retrovesicular ganglion neurons. Expressed in vulval muscles of hermaphrodites and lateral seam and tail seam cells of males. Expressed in spermatozoa within the spermatheca of hermaphrodites.
messages: Mainly embryonic lethal (PubMed:9224715). Mutants have defective body morphogenesis (PubMed:9224715). Embryos have few or no hypodermal cells, but more neuronal and muscle cells due to defective cell divisions and cell fate specification of ABarp- and ABpla-derived and C blastomere hypodermal precursor cells of the blastomere (PubMed:9224715). Defective alae formation and bursting vulva phenotype at the L4 stage of larval development (PubMed:25816370). RNAi-mediated knockdown results in a reduced brood size, complete or half-sterility and male tail defects (PubMed:19591818). Sterility may be due to sperm infertility and sperm morphological and mobility defects (PubMed:19591818). RNAi-mediated knockdown results in flaccidity, locomotion defects, herniating gonad and gross cuticle abnormalities which may be attributed to seam cell loss, and abnormal tail morphology and reduced tail seam cells in males (PubMed:16303852). Ninety percent of embryos produced by animals fed RNAi for more than 10 hours arrest early in development (PubMed:16303852). Embryos laid 6-10 hours after RNAi administration develop to the L1 stage of larval development, but display a lumpy dumpy phenotype with reduced elt-3 expression in dorsal and ventral hypodermal cells and greatly reduced seam cells with disorganised alignment and abnormal fusion of present seam cells (PubMed:16303852). RNAi-mediated knockdown at the L1, L2 or L3 larval stages results in a general loss of structural integrity 2-4 hours following the L4 larval stage to adult molt transition (PubMed:16303852). RNAi-mediated knockdown in temperature sensitive mutants leads to abnormal dauer formation with the majority of larvae arresting and appearing dauer-like following 30-35 hours after RNAi feeding (PubMed:16303852). Surviving larvae are wider in diameter than wild-type, have reduced motility, no pharyngeal pumping, granular appearance of the hypodermal and gut cytoplasm and dauer-like gonad morphology (PubMed:16303852). 40 and …
messages: Nucleus
messages: Perikaryon
messages: Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof (PubMed:19591818, PubMed:21829390). During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage (PubMed:9224715, PubMed:16303852, PubMed:11259601). The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres (PubMed:9224715). Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion (PubMed:16303852). Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif (PubMed:21829390). Probably represses expression of eff-1 to prevent fusion of seam cells with the hypodermal syncytium (PubMed:21829390). Involved in regulating expression of elt-3, a probable downstream target in hypodermal development pathways, in dorsal and ventral hypodermal cells (PubMed:16303852, PubMed:11259601). During postembryonic development, has a role in sperm development (PubMed:19591818, PubMed:29702639). Specifically, binds the bipartite consensus sequence 5'-AGATCTx(8)GATAA-3' found in genes with sperm-specific expression (PubMed:19591818). Furthermore, regulates timing of developmental steps, possibly in parallel with daf-12, by controlling the expression of the let-7 family of miRNAs which in turn determines the transcription of heterochronic genes such as lin-41 (PubMed:25816370).
messages: axon

6239:CELE F56H11.1
gene id: 6239:CELE_F56H11.1
uniprot id: A0A061ACF5
uniprot id: A0A061ACI3
uniprot id: A0A061ADQ1
uniprot id: A0A061AIV4
uniprot id: A0A061AKL1
uniprot id: O77469
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although involved in the same pathway as gon-1 and mig-17, it is probably not cleaved by these metalloproteases.
messages: Belongs to the fibulin family.
messages: Expressed from late embryonic stage onwards.
messages: Expressed in head muscle cells, anterior and posterior intestinal cells (PubMed:15556862). Isoform a: Expressed in male and hermaphrodite gonad, anterior and posterior intestine and pharyngeal basement membranes, body-wall muscle, GLR cells, uterine attachment and mechanosensory neurons (PubMed:15556863, PubMed:16120639, PubMed:17043142). Isoform c: Expressed on ALM/PLM mechanosensory neuron attachments, in flexible tracks connecting the pharyngeal, body-wall-muscle basement membranes and in uterine attachments (PubMed:16120639).
messages: Gonads have short and swollen arms. Pharyngeal defects. Movement is lethargic.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Involved in regulating the shape and adhesion of cells in the developing pharynx, intestine, body-wall muscle and gonadal tissue (PubMed:16120639). During gonadogenesis, regulates the width of gonads and the migration of distal tip cells (DTC) (PubMed:15556862, PubMed:17043142, PubMed:22298704). Together with type IV collagen let-2 and downstream of metalloprotease mig-17, recruits nidogen nid-1 to the gonad basement membrane thereby inducing basement membrane remodeling required for the directional migration of DTCs (PubMed:15556863, PubMed:19104038). Acts antagonistically with metalloprotease gon-1 to maintain optimal levels of type IV collagen emb-9 in the gonad basement membrane during gonadogenesis (PubMed:15556862, PubMed:17043142, PubMed:22298704). Required for larval development (PubMed:17043142).
messages: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall-muscle basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane
messages: extracellular matrix

6239:CELE H43I07.3
gene id: 6239:CELE_H43I07.3
uniprot id: Q8WSL9
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

6239:CELE ZK593.7
gene id: 6239:CELE_ZK593.7
uniprot id: Q23543
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

6239:CELE Y57A10B.5
gene id: 6239:CELE_Y57A10B.5
uniprot id: Q9XWH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T02C12.1
gene id: 6239:CELE_T02C12.1
uniprot id: G5ECZ0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE R05D3.12
gene id: 6239:CELE_R05D3.12
uniprot id: P34534
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity).
messages: Homodimer.
messages: Mitochondrion

6239:CELE C54G10.4
gene id: 6239:CELE_C54G10.4
uniprot id: M1ZJU4
uniprot id: Q8I4M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE F57G9.1
gene id: 6239:CELE_F57G9.1
uniprot id: O62266
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE ZK418.1
gene id: 6239:CELE_ZK418.1
uniprot id: Q23489
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T20D4.6
gene id: 6239:CELE_T20D4.6
uniprot id: P91469
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE C36B1.8
gene id: 6239:CELE_C36B1.8
uniprot id: Q8I4M5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed both maternally and zygotically throughout development and in adult hermaphrodites (at protein level).
messages: Expressed in the germline (at protein level). In the early embryo is expressed in all cells, then becomes gradually restricted to the germ cell lineage and enriches in P granules (at protein level). In adult hermaphrodites, is expressed in the mitotic region, accumulates during early stages of meiotic prophase I and is slightly less abundant in maturing oocytes (at protein level).
messages: Isoform C interacts (via C-terminus) with gld-3 isoform A (via C-terminus) in an RNA-independent manner. Isoform C interacts with gld-4.
messages: Loss of maternal and zygotic expression causes germline survival defects. Zygotic mutants show a masculinized hermaphrodite germline. At 25 degress Celsius, hermaphrodite zygotic mutants show small oogenic cells that are either arrested in pachytene or have undergone abnormal meiotic prophase progression and failed to arrest in diakinesis, often resulting in endoreduplicating oocyte nuclei.
messages: Required maternally for germline survival by forming a maternal complex with gld-3. During hermaphrodite development forms a complex with gld-3 which promotes the sperm/oocyte switch freeing the translational repressor fbf to turn off sperm promoting factors. Required for proper oocyte differentiation and oogenic meiotic arrest. Stimulates the enzymatic activity of gld-4 and together they prevent gld-1 mRNA degradation.
messages: Trans-spliced exclusively to SL2, suggesting a transcriptional coregulation with the upstream gene dhfr-1.

6239:CELE C36H8.3
gene id: 6239:CELE_C36H8.3
uniprot id: Q18502
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: Expressed in eggs and larvae, but not in adults.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: KPSFVRF-amide: Has no effect on somatic body wall muscle, inhibits contraction of vaginal vera muscle, and inhibits the activity of the dissected pharyngeal myogenic muscle system (PubMed:9920762, PubMed:16187307). Acts as a ligand for the npr-22 receptor in vitro (PubMed:16377032).
messages: Secreted

6239:CELE Y67H2A.4
gene id: 6239:CELE_Y67H2A.4
uniprot id: Q95PZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the MICU1 family. MICU1 subfamily.
messages: Expressed at low levels in PLM touch receptor neurons, germ cells, epidermis, and muscles.
messages: Key regulator of mitochondrial calcium uniporter (MCU). Modulates the activity of the mitochondrial calcium uniporter protein mcu-1 depending on the level of intracellular calcium in PLM touch receptor neurons following axonal injury (PubMed:31983639).
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

6239:CELE W04A4.4
gene id: 6239:CELE_W04A4.4
uniprot id: O18165
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F42A10.2
gene id: 6239:CELE_F42A10.2
uniprot id: H2KYX2
uniprot id: H2KYX3
uniprot id: Q5LK46
names: Subcellular Location Annotation
messages: Membrane
messages: adherens junction
messages: cytoskeleton

6239:CELE F47B10.2
gene id: 6239:CELE_F47B10.2
uniprot id: Q20502
names: Disruption Phenotype
names: PTM
names: Similarity
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.
messages: Defective histidine metabolism resulting in elevated histidine levels and resistance to nickel and zinc toxicity. Additionally, slightly resistant to copper, slightly sensitive to cobalt and iron and substantially sensitive to manganese.

6239:CELE K05B2.3
gene id: 6239:CELE_K05B2.3
uniprot id: P90900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein.
messages: Expressed in the larva in the pharyngeal-intestinal valve, the rectum and some neurons of the tail. Highly expressed in the intestine of the newly formed dauer larva. Colocalizes with ifb-1. Not expressed in the intestine of normal developmental stages.
messages: Probably forms some heteromeric filaments with ifb-1.

6239:CELE T09E11.9
gene id: 6239:CELE_T09E11.9
uniprot id: O02309
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE Y111B2A.11
gene id: 6239:CELE_Y111B2A.11
uniprot id: G5EC14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

6239:CELE K07A1.3
gene id: 6239:CELE_K07A1.3
uniprot id: P90910
names: Similarity
messages: Belongs to the UPF0692 family.

6239:CELE T13F3.2
gene id: 6239:CELE_T13F3.2
uniprot id: O18086
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK652.2
gene id: 6239:CELE_ZK652.2
uniprot id: P34660
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom7 family.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
messages: Mitochondrion outer membrane

6239:CELE Y73F4A.2
gene id: 6239:CELE_Y73F4A.2
uniprot id: Q9XWC3
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C52B9.7
gene id: 6239:CELE_C52B9.7
uniprot id: Q22943
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

6239:CELE C04F5.5
gene id: 6239:CELE_C04F5.5
uniprot id: Q7KNQ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK1321.3
gene id: 6239:CELE_ZK1321.3
uniprot id: Q09369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE ZC317.5
gene id: 6239:CELE_ZC317.5
uniprot id: Q23077
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T05F1.10
gene id: 6239:CELE_T05F1.10
uniprot id: O18030
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE Y53F4B.12
gene id: 6239:CELE_Y53F4B.12
uniprot id: Q9NAB9
uniprot id: U4PLX3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05B4.3
gene id: 6239:CELE_T05B4.3
uniprot id: O16424
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C50D2.7
gene id: 6239:CELE_C50D2.7
uniprot id: Q86S40
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity).
messages: Monomer.
messages: Secreted

6239:CELE F27D9.1
gene id: 6239:CELE_F27D9.1
uniprot id: P34815
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Abundant at the early larval stage, decreased amounts seen at the fourth larval and the adult stages.
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: May participate in the axonal transport system and influences the acetylcholine flow in motor neurons (PubMed:1347782, PubMed:8398155). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142).
messages: Motor neurons and a limited number of neurons constituting nerve ganglia.

6239:CELE ZK666.8
gene id: 6239:CELE_ZK666.8
uniprot id: Q23566
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE ZK1151.1
gene id: 6239:CELE_ZK1151.1
uniprot id: A0A1N7SYN7
uniprot id: A0A1N7SYN9
uniprot id: A0A1N7SYP3
uniprot id: A0A1N7SYR7
uniprot id: G5ECP9
uniprot id: G5EFD1
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE F41B4.4
gene id: 6239:CELE_F41B4.4
uniprot id: Q8MXV7
uniprot id: Q8MXV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane

6239:CELE C55H1.2
gene id: 6239:CELE_C55H1.2
uniprot id: Q9BIG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE Y37A1B.10
gene id: 6239:CELE_Y37A1B.10
uniprot id: Q9U2P2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK1127.1
gene id: 6239:CELE_ZK1127.1
uniprot id: Q23406
names: Similarity
messages: Belongs to the nanos family.

6239:CELE B0025.2
gene id: 6239:CELE_B0025.2
uniprot id: O01422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN2 family.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-1, csn-3 and csn-4.
messages: Cytoplasm
messages: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Nucleus

6239:CELE F45H10.2
gene id: 6239:CELE_F45H10.2
uniprot id: O45525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE T28F2.7
gene id: 6239:CELE_T28F2.7
uniprot id: O01664
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C46H11.2
gene id: 6239:CELE_C46H11.2
uniprot id: Q9GYJ1
names: Similarity
messages: Belongs to the FMO family.

6239:CELE Y48A6B.9
gene id: 6239:CELE_Y48A6B.9
uniprot id: Q9XXC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
messages: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.
messages: Homodimer.
messages: Mitochondrion

6239:CELE Y49E10.11
gene id: 6239:CELE_Y49E10.11
uniprot id: Q9U280
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Recycling endosome membrane
messages: Results in abnormal formation of intestinal vacuoles.
messages: Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet (PubMed:18436785, PubMed:21170358, PubMed:23427264). Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes (PubMed:18436785). Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintenance and control of the membrane surface charge (PubMed:23427264). Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo, likely with its chaperone protein chat-1 (PubMed:21170358, PubMed:23427264).

6239:CELE Y38C1AA.13
gene id: 6239:CELE_Y38C1AA.13
uniprot id: D6RYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

6239:CELE F35C5.12
gene id: 6239:CELE_F35C5.12
uniprot id: G5EEA5
names: Subcellular Location Annotation
messages: Secreted

6239:CELE ZC513.5
gene id: 6239:CELE_ZC513.5
uniprot id: Q23361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane

6239:CELE C48E7.2
gene id: 6239:CELE_C48E7.2
uniprot id: Q8IG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

6239:CELE Y105E8B.5
gene id: 6239:CELE_Y105E8B.5
uniprot id: Q9NF11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

6239:CELE H25P06.2
gene id: 6239:CELE_H25P06.2
uniprot id: Q9TVL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with cyclin-T (cit-1.1 or cit-1.2) to form P-TEFb.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5.
messages: Nucleus

6239:CELE Y57G11C.46
gene id: 6239:CELE_Y57G11C.46
uniprot id: Q7YTI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE K02B2.4
gene id: 6239:CELE_K02B2.4
uniprot id: Q21123
uniprot id: V6CLI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE F42A10.9
gene id: 6239:CELE_F42A10.9
uniprot id: Q65ZK1
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

6239:CELE W04C9.6
gene id: 6239:CELE_W04C9.6
uniprot id: Q9TZE1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R04B5.3
gene id: 6239:CELE_R04B5.3
uniprot id: Q21700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T27D12.2
gene id: 6239:CELE_T27D12.2
uniprot id: G5EDQ0
uniprot id: Q22833
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK354.1
gene id: 6239:CELE_ZK354.1
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C15H9.5
gene id: 6239:CELE_C15H9.5
uniprot id: Q18024
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F57A8.2
gene id: 6239:CELE_F57A8.2
uniprot id: Q20913
uniprot id: Q2PJ77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

6239:CELE F07H5.10
gene id: 6239:CELE_F07H5.10
uniprot id: Q19174
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE H14A12.4
gene id: 6239:CELE_H14A12.4
uniprot id: O17212
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: During the larval stage of development, expressed in uterine muscle progenitors and their descendants in the sex myoblast lineage, but only expressed in type 2 vulval muscle precursor cells of the vulval muscle lineage (PubMed:11799068). In larvae, it is also expressed in a subset of enteric muscle cells including the left and right intestinal muscles and the anal depressor muscle (PubMed:11799068, PubMed:21852953).
messages: May interact with unc-37.
messages: Non-striated muscle cell fate specification defects whereby the number of vulval cells is doubled and the number of uterine cells is reduced due to the transformation of uterine cells into vulval cells.
messages: Nucleus
messages: Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells (PubMed:11799068, PubMed:21852953). Furthermore, may function with the transcriptional corepressor unc-37 (PubMed:21852953).

6239:CELE Y57A10A.11
gene id: 6239:CELE_Y57A10A.11
uniprot id: Q9NA83
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F14F4.1
gene id: 6239:CELE_F14F4.1
uniprot id: O62169
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Detected in the ADL sensory neurons, the RMED and RMEV motor neurons, and the PQR tail neuron (PubMed:23112336). In males, detected in SPC tail neurons involved in spicule penetration and sperm transfer, and male-specific oblique muscles involved in vulval contact (PubMed:23112335).
messages: Not directly activated by nematocin (PubMed:23112336, PubMed:23112335). May modulate activity of the nematocin receptor ntr-1, leading to reduced intracellular cAMP production (PubMed:23112335). Plays a role in male mating behavior (PubMed:23112335).
messages: Viable and fertile. Males have reduced reproductive success, due to a range of aberrant mating behaviors. Double knockouts with ntr-1 partially rescue the reproductive phenotypes.

6239:CELE C29H12.1
gene id: 6239:CELE_C29H12.1
uniprot id: Q18316
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE R03E1.2
gene id: 6239:CELE_R03E1.2
uniprot id: Q9XTY9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F23B2.4
gene id: 6239:CELE_F23B2.4
uniprot id: G5EFW7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the IFT complex A (IFT-A) composed of at least che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
messages: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:28479320). Plays a role in chemotaxis and sensory perception (PubMed:7240452, PubMed:7705621). Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41 (PubMed:7240452, PubMed:23284299, PubMed:25830239). Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa (PubMed:23284299).
messages: Sterile. Defective chemotaxis with 86% of mutants exhibiting reduced tracking to the chemoattractant ammonium chloride.
messages: cilium

6239:CELE T01B11.2
gene id: 6239:CELE_T01B11.2
uniprot id: P91408
names: Caution
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Does not seem to possess aminotransferase activity.

6239:CELE Y53C12B.3
gene id: 6239:CELE_Y53C12B.3
uniprot id: O18218
uniprot id: O62486
names: Similarity
messages: Belongs to the nanos family.

6239:CELE T01C4.1
gene id: 6239:CELE_T01C4.1
uniprot id: Q94298
names: Similarity
messages: Belongs to the plant self-incompatibility (S1) protein family.

6239:CELE C53D6.3
gene id: 6239:CELE_C53D6.3
uniprot id: Q18812
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylcholine-gated chloride channel subunit. Currents in channels are triggered in response to acetylcholine. Channel properties may be modulated by the formation of homomeric and heteromeric channels.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Expressed in RIA, RIG, PHA and AIZ glutamatergic neurons, URX and RIH cholinergic neurons, and in male-specific MCM neurons.
messages: Grossly normal movement.
messages: Homopentamer (in vitro). May interact with either acc-3 or acc-4; the interactions do not result in significant heteropentameric ion channel activity.

6239:CELE H04M03.1
gene id: 6239:CELE_H04M03.1
uniprot id: Q9TYQ8
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

6239:CELE F58B6.2
gene id: 6239:CELE_F58B6.2
uniprot id: Q9TYU9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the formin homology family.
messages: Constitutively active protein required for microtubule and F-actin growth, structural maintenance and organization during excretory cell tubulogenesis.
messages: Defective cytoskeleton organization characterized by disrupted F-actin and microtubule dynamics leading to abnormal excretory cell tubulogenesis. Specifically, F-actin structure and organization in excretory cell canals throughout life is disrupted and microtubule organizing centers accumulate at the tips of excretory cell canals, with a strong reduction along the canals, and the direction of microtubule growth is altered.
messages: Expressed in the excretory cell and mostly accumulates at the tip of the excretory cell canals.
messages: cytoskeleton

6239:CELE F01F1.6
gene id: 6239:CELE_F01F1.6
uniprot id: P46562
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

6239:CELE T28C6.4
gene id: 6239:CELE_T28C6.4
uniprot id: G5EDG6
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T26G10.1
gene id: 6239:CELE_T26G10.1
uniprot id: P34580
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Nucleus
messages: Probable ATP-dependent RNA helicase which may be involved in ribosome biogenesis.

6239:CELE ZK742.1
gene id: 6239:CELE_ZK742.1
uniprot id: Q23089
names: Similarity
messages: Belongs to the exportin family.

6239:CELE T03F1.8
gene id: 6239:CELE_T03F1.8
uniprot id: A5HU98
uniprot id: P91425
names: Similarity
messages: Belongs to the guanylate kinase family.

6239:CELE ZC410.2
gene id: 6239:CELE_ZC410.2
uniprot id: Q23295
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binding to mppa-1 is required for catalytic activity (PubMed:16788047). Inhibited by metal chelator ethylenediaminetetraacetic acid (EDTA) (PubMed:16788047).
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2 (Probable).
messages: Heterodimer of mppa-1 (alpha) and mppb-1 (beta) subunits, forming the mitochondrial processing protease (MPP) in which mppa-1 is involved in substrate recognition and binding and mppb-1 is the catalytic subunit.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown causes 54 percent embryonic lethality (PubMed:16788047). Embryonic lethality is further increased in simultaneous RNAi-mediated knockdown of mmpa-1 and mmpb-1 or ucr-1 and mppb-1 (PubMed:16788047).

6239:CELE C06H2.4
gene id: 6239:CELE_C06H2.4
uniprot id: Q17766
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Folate transporter.
messages: Highly expressed in pharynx and posterior part of the intestine. Expressed at lower levels in the body wall muscles, head muscles, and vulva muscles. Highly expressed in the intestine of the early larva, levels decrease in the later stages of development.
messages: Membrane
messages: Worms display defects in folate uptake, reproduction and movement.

6239:CELE C04F6.5
gene id: 6239:CELE_C04F6.5
uniprot id: Q11177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane

6239:CELE C27C12.5
gene id: 6239:CELE_C27C12.5
uniprot id: G3MU02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C12C8.3
gene id: 6239:CELE_C12C8.3
uniprot id: Q9U489
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Expressed in body wall muscles, pharyngeal muscles and most neurons at all stages from late embryogenesis until adulthood. Expressed in hypodermal seam cells until the L4 stage.
messages: Heterochronic protein which acts downstream of let-7 in temporal patterning (PubMed:10882102, PubMed:30910805). Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production (PubMed:28933985). Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division (PubMed:10882102). Involved in post-transcriptional gene regulation, uses two independent pathways (PubMed:28157501). Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repression of translation (PubMed:28111013, PubMed:30910805). Degrades the mRNA of transcription factor dmd-3 to govern the timing and extent of male tail tip morphogenesis (PubMed:16806150, PubMed:18550714, PubMed:28111013, PubMed:30910805, PubMed:26811380, PubMed:30956008). Plays a role in the sexual maturation of the nervous system (PubMed:31264582).
messages: Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein.
messages: P-body
messages: RNAi-mediated knockdown results in the precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype) (PubMed:26811380, PubMed:30956008). RNAi-mediated knockdown results in increased expression of dmd-3.
messages: The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression.

6239:CELE F49B2.5
gene id: 6239:CELE_F49B2.5
uniprot id: O45539
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Expressed in vulva, cells around anus and pharyngeal muscles.
messages: May be inhibited by csk-1-mediated phosphorylation at Tyr-500.
messages: May be phosphorylated on Tyr-500 by csk-1.
messages: Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development.
messages: RNAi-mediated knockdown causes no obvious effect on embryonic development (PubMed:12527374). Animals have a slight decrease in unc-5 tyrosine phosphorylation (PubMed:16024786).

6239:CELE Y50E8A.6
gene id: 6239:CELE_Y50E8A.6
uniprot id: Q9NAF2
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

6239:CELE T12G3.4
gene id: 6239:CELE_T12G3.4
uniprot id: Q22437
names: Similarity
messages: Belongs to the strictosidine synthase family.

6239:CELE F23C8.7
gene id: 6239:CELE_F23C8.7
uniprot id: Q9TXI2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F23H12.2
gene id: 6239:CELE_F23H12.2
uniprot id: Q19766
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom20 family.
messages: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (PubMed:21264209).
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown results in impaired mitochondrial homeostasis with the up-regulation of the mitochondrial unfolded protein chaperone hsp-6 and impaired daf-28/insulin secretion.

6239:CELE ZK686.5
gene id: 6239:CELE_ZK686.5
uniprot id: Q7Z142
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK783.4
gene id: 6239:CELE_ZK783.4
uniprot id: Q23590
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WAL family.
messages: Broadly expressed in the nervous system, including head, body and tail neurons.
messages: Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178). Positively modulates the level of global trimethylated 'Lys-9' of histone H3 (H3K9me3), but not of H3K9me2 or H3K9me1 (PubMed:32103178). May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with histone methyltransferase, set-6 (PubMed:32103178). Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178). Negatively regulates expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase), with aging (PubMed:32103178). Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178). Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
messages: Chromosome
messages: Expression increases with age.
messages: Interacts with set-6.
messages: Nucleus
messages: RNAi-mediated knockdown prevents age-related decline in the expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178). RNAi-mediated knockdown improves behavioral performance in pharyngeal pumping in aged worms (PubMed:32103178).

6239:CELE Y18H1A.6
gene id: 6239:CELE_Y18H1A.6
uniprot id: G5EFV7
uniprot id: V6CIU3
uniprot id: V6CL86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family.
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

6239:CELE T19C4.2
gene id: 6239:CELE_T19C4.2
uniprot id: Q22569
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE F32H5.7
gene id: 6239:CELE_F32H5.7
uniprot id: G5EEH1
uniprot id: K8ERV0
uniprot id: K8ESK0
uniprot id: K8FDZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F27E5.2
gene id: 6239:CELE_F27E5.2
uniprot id: G5ED66
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Expressed throughout embryogenesis and early larval development, predominantly in hypodermal cells, especially ventral P cells and their descendants.
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic lethality, vulval and gonad migration defects, and animals that survive have mild to severe body morphology defects (PubMed:26953187). A marker of the lateral hypodermal (seam cell) fate, scm, is expressed ectopically in some P cell nuclei during the early larval L1 stage (PubMed:26953187).
messages: Transcriptional activator (By similarity). Regulates the lateral/ventral epidermal cell fate decision (PubMed:26953187).

6239:CELE Y105E8A.10
gene id: 6239:CELE_Y105E8A.10
uniprot id: Q6EUT4
uniprot id: Q8WQB2
names: Function
names: Similarity
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

6239:CELE K01G5.4
gene id: 6239:CELE_K01G5.4
uniprot id: O17915
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Chromosome
messages: Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).
messages: Loss of ran-1 results in failure of correct attachment of kinetochore microtubules to mitotic chromosomes and the resultant loss of correct chromosome segregation. The number and the location of centrosomes are normal, and astral mictrotubules also seem unaffected. Nuclear envelope is not reestablished at the end of each cell division.
messages: Nucleus
messages: Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
messages: kinetochore

6239:CELE C24H11.1
gene id: 6239:CELE_C24H11.1
uniprot id: Q9U3P4
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE W08E3.3
gene id: 6239:CELE_W08E3.3
uniprot id: P91917
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Expressed in the nervous system, pharyngeal muscles and intestine (at protein level).
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. Plays a role in regulating starvation-induced thermotaxis responses in AFD thermosensory neurons (PubMed:35675262).
messages: Monomer.

6239:CELE F22B7.6
gene id: 6239:CELE_F22B7.6
uniprot id: P34409
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).
messages: Divalent metal cations. Prefers Mg(2+), but can also use Mn(2+).
messages: Nucleus
messages: The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity.

6239:CELE T05C12.10
gene id: 6239:CELE_T05C12.10
uniprot id: G5EC21
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasmic vesicle
messages: Mainly expressed in all hypodermal cells (hyp1 to hyp11) from the tip of the head to the tip of the tail from late embryogenesis to adulthood, and expressed in the excretory duct and pore cells from the 3-fold stage of embryogenesis to adulthood. Expressed in intestinal and rectal cells, sensilla support cells, and transiently in the P lineage during the L1 stage of larval development. Temporal expression during the molt phases from larval development stage L2 to L4 with high expression prior to and during the L2 and L3 molt, but low expression between the molting phases, and low expression after the L4 molt.
messages: Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development.
messages: Secreted
messages: Transiently expressed in head cells.
messages: extracellular matrix

6239:CELE ZK688.9
gene id: 6239:CELE_ZK688.9
uniprot id: P34274
names: Similarity
messages: Belongs to the TIP41 family.

6239:CELE T10F2.1
gene id: 6239:CELE_T10F2.1
uniprot id: Q10039
uniprot id: Q8I711
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
messages: Cytoplasm
messages: Homodimer.
messages: RNAi-mediated knockdown results in larval lethality. RNAi-mediated knockdown in the germline results in 100% sterility at 25 degrees Celsius.
messages: Secreted
messages: axon
messages: extracellular exosome

6239:CELE R12G8.2
gene id: 6239:CELE_R12G8.2
uniprot id: Q9XTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE R05A10.6
gene id: 6239:CELE_R05A10.6
uniprot id: O45703
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F38A5.1
gene id: 6239:CELE_F38A5.1
uniprot id: Q94218
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Aberrant localization of odr-10, str-2, str-112 and str-113. Reduced response to odorants mediated by AWA and AWC olfactory neurons. Increased aggregation and response to O2 levels when knocked down with npr-1.
messages: Belongs to the peptidase C78 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Expressed in head and tail neurons (PubMed:24603482). Expressed in the amphid head neurons ADL, ASI, ASH, ASJ, ASG, ADF, ASK, AWA, AWB, AWC, and in two tail neurons, the phasmid tail neurons PHA and PHB (PubMed:23449979).
messages: Interacts with odr-4.
messages: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:29251776, PubMed:24603482). Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC (PubMed:9590179). Operates in aggregation behavior, and responses to oxygen levels (PubMed:12410303).
messages: perinuclear region

6239:CELE Y50D7A.7
gene id: 6239:CELE_Y50D7A.7
uniprot id: O45218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
messages: Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
messages: Homodimer.
messages: Peroxisome

6239:CELE ZK1025.9
gene id: 6239:CELE_ZK1025.9
uniprot id: Q9XXL8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE M01G12.9
gene id: 6239:CELE_M01G12.9
uniprot id: O62317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE ZK1248.14
gene id: 6239:CELE_ZK1248.14
uniprot id: Q23424
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.
messages: Mitochondrion outer membrane
messages: Probable transmembrane GTPase (By similarity). Mediates mitochondrial fusion (PubMed:21248201, PubMed:25190516). Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity).
messages: RNAi-mediated knockdown results in fragmented mitochondria, most likely due to lack of fusion activity (PubMed:25190516). RNAi-mediated knockdown in a moma-1 mutant background results in mitochondrial fragmentation.

6239:CELE Y57E12AL.5
gene id: 6239:CELE_Y57E12AL.5
uniprot id: Q9N337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex (By similarity). Interacts with let-19/mdt-13 (PubMed:15790964). Interacts with RNA polymerase II (PubMed:10611325). Interacts with mdt-28 (PubMed:28603670).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Acts to repress beta-catenin target genes. Required for asymmetric division of T-cells and for gonad and germ cell development.
messages: Nucleus

6239:CELE F58E10.2
gene id: 6239:CELE_F58E10.2
uniprot id: G5EDN4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK616.6
gene id: 6239:CELE_ZK616.6
uniprot id: Q9N4N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE C24F3.3
gene id: 6239:CELE_C24F3.3
uniprot id: Q9XTD6
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal glands.
messages: Metalloprotease.
messages: Secreted

6239:CELE M199.5
gene id: 6239:CELE_M199.5
uniprot id: G3MU58
uniprot id: Q86D04
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE C06A5.7
gene id: 6239:CELE_C06A5.7
uniprot id: O01479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity).
messages: Belongs to the tropomodulin family.
messages: Binds to the N-terminus of actin.
messages: cytoskeleton

6239:CELE F31B9.1
gene id: 6239:CELE_F31B9.1
uniprot id: O62189
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F43H9.2
gene id: 6239:CELE_F43H9.2
uniprot id: Q20375
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.
messages: Heterodimer of sptl-1/sptl-2.

6239:CELE ZK970.3
gene id: 6239:CELE_ZK970.3
uniprot id: Q23679
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F22D6.3
gene id: 6239:CELE_F22D6.3
uniprot id: Q19722
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress.

6239:CELE K02G10.7
gene id: 6239:CELE_K02G10.7
uniprot id: Q7Z137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE R102.5
gene id: 6239:CELE_R102.5
uniprot id: Q9U389
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophagy receptor, which is required for allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in early embryos. After fertilization, recruited to ubiquitin-modified paternal organelles and is required for the formation of autophagosomes around the paternal organelles. Also plays a role in the regulation of autophagy in germ cells.
messages: Cytoplasm
messages: Expressed in oocytes, but not in spermatozoa.
messages: Phosphorylation on Thr-74 by ikke-1 is required for allophagic function.
messages: Self-associates. Interacts (via N-terminus) with ikke-1; the interaction is direct. Interacts (via the LIR motif) with lgg-1. Interacts (via C-terminus) with ubiquitinated proteins.
messages: The C-terminal region is required for localization to paternal organelles.

6239:CELE D1081.9
gene id: 6239:CELE_D1081.9
uniprot id: Q9U3L0
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in the germline.
messages: Interacts with zhp-1; the interaction is required for their chromosome association and stability.
messages: Recruited co-dependently with zhp-1 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:29521627). Together with zhp-1, promotes the accumulation of pro-crossover proteins, including zhp-3 and zhp-4, at a designated crossover site along the recombination intermediate (PubMed:29521627). Limits the number of crossover sites along a recombination intermediate by restricting the association of these pro-crossover proteins with other recombination sites during late prophase (PubMed:29521627). Also, together with zhp-1, plays a role in chromosome remodeling following crossover formation to promote two successive rounds of chromosome segregation during meiosis (PubMed:29521627).

6239:CELE F49C12.12
gene id: 6239:CELE_F49C12.12
uniprot id: Q20589
uniprot id: X5LX67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase K family.
messages: Membrane

6239:CELE K07F5.3
gene id: 6239:CELE_K07F5.3
uniprot id: P05634
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE D2089.1
gene id: 6239:CELE_D2089.1
uniprot id: O01159
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus

6239:CELE C25A1.6
gene id: 6239:CELE_C25A1.6
uniprot id: Q9XVR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP10 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE C25D7.1
gene id: 6239:CELE_C25D7.1
uniprot id: Q9U3P3
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE Y62E10A.12
gene id: 6239:CELE_Y62E10A.12
uniprot id: Q9U1W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

6239:CELE F38E1.5
gene id: 6239:CELE_F38E1.5
uniprot id: P22454
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in behavioral responses to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons (PubMed:25303524).

6239:CELE C43E11.9
gene id: 6239:CELE_C43E11.9
uniprot id: P91154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

6239:CELE Y58A7A.1
gene id: 6239:CELE_Y58A7A.1
uniprot id: D6RYD3
uniprot id: Q966A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6239:CELE R01H10.1
gene id: 6239:CELE_R01H10.1
uniprot id: Q21625
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A (By similarity).
messages: Delayed cell divisions/cytokinesis. Dysfunctional development of intestinal and pharyngeal cells. Mislocalization of p-granules to the nuclei at the 4- and 12-cell embryonic growth stages. Loss of cell polarity during cell divisions.
messages: May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Required for the distribution of pie-1 in cell divsion.
messages: Nucleus

6239:CELE Y47D7A.8
gene id: 6239:CELE_Y47D7A.8
uniprot id: Q9N3U9
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE K08B12.2
gene id: 6239:CELE_K08B12.2
uniprot id: O01582
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZC404.9
gene id: 6239:CELE_ZC404.9
uniprot id: Q23290
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

6239:CELE C44C3.2
gene id: 6239:CELE_C44C3.2
uniprot id: P91159
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F32A5.4
gene id: 6239:CELE_F32A5.4
uniprot id: Q19948
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I33 family.
messages: Secreted

6239:CELE C34E10.2
gene id: 6239:CELE_C34E10.2
uniprot id: P46577
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Cytoplasm
messages: Heterodimer with GPN3. Binds to RNA polymerase II (RNAPII).
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

6239:CELE T06D10.2
gene id: 6239:CELE_T06D10.2
uniprot id: Q9U380
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C49C3.4
gene id: 6239:CELE_C49C3.4
uniprot id: A0A0K3ARI2
uniprot id: Q9XUF9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F02D10.5
gene id: 6239:CELE_F02D10.5
uniprot id: G5EGI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C46E1.2
gene id: 6239:CELE_C46E1.2
uniprot id: Q6DNF4
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in URX, AQR and PQR neurons.
messages: Heterodimer; heterodimerizes with gcy-35, and possibly with other soluble guanylate cyclases.
messages: Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyperoxia and for oxygen-induced aggregation and bordering, probably by mediating oxygen sensing in URX, AQR and PQR sensory neurons.
messages: Regulated by molecular oxygen, which binds to the heme binding site. Probably not activated by nitric oxide (NO) (By similarity).
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE Y47D9A.2
gene id: 6239:CELE_Y47D9A.2
uniprot id: Q9N4V4
names: Function
names: Similarity
messages: Belongs to the CTDSPL2 family.
messages: Probable phosphatase.

6239:CELE Y57A10C.4
gene id: 6239:CELE_Y57A10C.4
uniprot id: O62489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y37E11B.5
gene id: 6239:CELE_Y37E11B.5
uniprot id: Q9TYN2
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

6239:CELE B0495.7
gene id: 6239:CELE_B0495.7
uniprot id: Q09216
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Endoplasmic reticulum membrane

6239:CELE Y65B4BR.5
gene id: 6239:CELE_Y65B4BR.5
uniprot id: Q86S66
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Cytoplasm
messages: May be part of the nascent polypeptide-associated complex (NAC), which is a heterodimer of icd-2 and icd-1 (via NAC-A/B domains).
messages: May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER) (By similarity). Plays a role in the response to heat stress (PubMed:22957041).
messages: RNAi-mediated knockdown in larvae results in increased survival and mobility in response to a constant temperature of 36 degrees Celsius, when compared to wild-type.

6239:CELE Y105E8A.11
gene id: 6239:CELE_Y105E8A.11
uniprot id: Q9NEY7
names: Similarity
messages: Belongs to the BolA/IbaG family.

6239:CELE C40H1.6
gene id: 6239:CELE_C40H1.6
uniprot id: Q03598
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
messages: E2-like enzyme which forms an intermediate with ufm-1 (PubMed:23449979). The intermediate is formed via a thioester linkage (By similarity).
messages: Expressed in the intestine.
messages: Interacts with uba-5.

6239:CELE Y17G7B.10
gene id: 6239:CELE_Y17G7B.10
uniprot id: Q9XXI5
uniprot id: Q9XXI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

6239:CELE F21F8.4
gene id: 6239:CELE_F21F8.4
uniprot id: O01531
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE Y18H1A.12
gene id: 6239:CELE_Y18H1A.12
uniprot id: V6CLD0
uniprot id: V6CLE3
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE T26A5.1
gene id: 6239:CELE_T26A5.1
uniprot id: Q22802
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

6239:CELE Y71F9AL.16
gene id: 6239:CELE_Y71F9AL.16
uniprot id: Q9N4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP3 subfamily.
messages: Component of the Arp2/3 complex.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
messages: cytoskeleton

6239:CELE T28C6.8
gene id: 6239:CELE_T28C6.8
uniprot id: Q9XVW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRI3 family.
messages: Membrane
messages: perinuclear region

6239:CELE C04F6.3
gene id: 6239:CELE_C04F6.3
uniprot id: Q11174
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

6239:CELE T02G5.7
gene id: 6239:CELE_T02G5.7
uniprot id: Q22101
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

6239:CELE T28C6.6
gene id: 6239:CELE_T28C6.6
uniprot id: G5EDG6
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C42D8.8
gene id: 6239:CELE_C42D8.8
uniprot id: Q10651
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the APP family.
messages: Early endosome
messages: Expressed in the head, pharynx, spermatheca, uterus, vulva, tail and ventral neurons (PubMed:18262516). Specifically expressed in nerve ring interneurons, the ventral cord, socket and amphids in the head, with strong expression in junctional cells, including the pharyngeal intestinal valve and uterine seam junction, and the excretory cell and weak expression in epidermal epithelial cells, including hyp7 cells, vulval cells, rectal valve cells, pharyngeal arcade cells and the tail hypodermis (PubMed:20862215).
messages: Extracellular region is proteolytically cleaved.
messages: Interacts (via cytoplasmic domain) with feh-1 (via PID 2 domain).
messages: Lacks conserved metal-binding sites and has only weak affinity for copper in vitro.
messages: Larval lethality during the L1 stage, with the formation of vacuoles in syncytial hypoderm, organ morphology defects, and molting defects (PubMed:17267616, PubMed:20862215). RNAi-mediated knockdown results in a reduced body size, transparent appearance, sluggish movement and insensitivity to touch (PubMed:18262516, PubMed:20862215). Delayed development and a molting defect that begins at the L3 to L4 larval stage transition and continues through to transition from the L4 larval stage to the young adult stage (PubMed:20862215). Increased sensitivity to acetylcholine inhibition (PubMed:20862215). Increased pharyngeal pumping (PubMed:11896189). In a let-7 mutant background, partial suppression of the let-7 bursting vulva phenotype (PubMed:28933985). Double RNAi-mediated knockdown with acn-1 in a let-7 mutant background leads to complete suppression of the heterochronic seam cell defects (PubMed:28933985).
messages: Membrane
messages: Required for normal developmental progression throughout all life stages (PubMed:18262516, PubMed:22466039). Specifically required for the molt stage during all larval transitions and morphogenesis (PubMed:18262516, PubMed:17267616, PubMed:22466039). Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition (PubMed:18262516, PubMed:28933985). Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells (PubMed:28933985). Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg-laying (PubMed:22466039). May play a role in neurotransmission (PubMed:20862215).
messages: Similar expression pattern in larval and adult cells with expression in neuronal, muscle, hypodermal and supporting cells (PubMed:17267616). Temporally expressed in seam cells from the middle of larval stage L4 and throughout adult stages (PubMed:18262516, PubMed:28933985).
messages: The NPXY motif mediates the interaction with clathrin.

6239:CELE F46H5.2
gene id: 6239:CELE_F46H5.2
uniprot id: Q20490
uniprot id: Q7Z1R2
names: Similarity
messages: Belongs to the FAM122 family.

6239:CELE T06E4.7
gene id: 6239:CELE_T06E4.7
uniprot id: Q22261
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y38C1AA.3
gene id: 6239:CELE_Y38C1AA.3
uniprot id: Q9N426
names: Similarity
messages: Belongs to the isochorismatase family.

6239:CELE Y53G8B.4
gene id: 6239:CELE_Y53G8B.4
uniprot id: A3KFD2
uniprot id: G4S7C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

6239:CELE R13H9.4
gene id: 6239:CELE_R13H9.4
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE R07E3.3
gene id: 6239:CELE_R07E3.3
uniprot id: Q21808
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expressed in seam cells in three-fold stage embryos and during dauer larvae formation (PubMed:15936343). Not expressed in adults (PubMed:15936343).
messages: Plays a role in alae formation in L1 and dauer stage larvae.
messages: RNAi-mediated knockdown results in disrupted alae formation in L1 and dauer stage larvae with alae often present on only one side of the larvae.

6239:CELE C24H11.4
gene id: 6239:CELE_C24H11.4
uniprot id: Q9XVD3
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE Y39G8B.4
gene id: 6239:CELE_Y39G8B.4
uniprot id: Q9U2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T04A11.12
gene id: 6239:CELE_T04A11.12
uniprot id: P83502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sru family.
messages: Membrane

6239:CELE Y55D9A.1
gene id: 6239:CELE_Y55D9A.1
uniprot id: G5EET6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: A short conserved N-terminal region is necessary for the function of this protein (PubMed:21943602, PubMed:26339988). Transient relocalization to microtubule minus ends after neuronal injury also requires this region (PubMed:26339988).
messages: Abnormally long and dense microtubules at the cellular cortex of early embryonic cells and growing microtubule plus ends reside at the cortex for up to five times longer. Causes excess centrosome separation and displacement towards the cellular cortex early in mitosis and subsequently a loss of anaphase spindle-pole oscillations and increased rates of spindle elongation. The centrosome separation phenotype is dependent on the motor protein dynein. Weakly delayed nuclear envelope breakdown (PubMed:21076413). Displays mild posterior lateral microtubule (PLM) axon overshooting in development and enhanced PLM regrowth following neuronal injury acting early in regrowth (PubMed:21943602). Axons display elevated numbers of growing microtubules in the steady (uninjured) state and display impenetrant developmental overgrowth in the absence of injury (PubMed:26339988).
messages: Cell membrane
messages: Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes (PubMed:21943602, PubMed:26339988). Limits microtubule growth near the cellular cortex of early embryonic cells (PubMed:21076413).
messages: Interacts (via short N-terminal region) with microtubule-associated proteins tac-1 and zyg-8.
messages: Isoform b: Enriched cortically both in the anterior portion of the one-cell zygote and at the blastomere boundary in two-cell embryos. Isoform c: Localizes to nonpolarized cellular cortex in oocytes and early one-cell zygotes and anterior cellular cortex in one-cell embryos subsequent to pseudocleavage. Present at the interface of the AB and P1 cells. Undetectable by the four-cell stage.
messages: cell cortex

6239:CELE C02B10.1
gene id: 6239:CELE_C02B10.1
uniprot id: G5EEH6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE K08F8.6
gene id: 6239:CELE_K08F8.6
uniprot id: Q93442
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex (By similarity). Interacts with sur-2/mdt-23 and let-425/mdt-6.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for asymmetric division of T-cells and for hypodermal development.
messages: Nucleus
messages: Ubiquitously expressed in larvae and embryos.
messages: Widely expressed in most adult tissues including the vulva, tail neurons, skeletal muscle, hypodermal cells, the excretory canal and pharynx.

6239:CELE T03F1.1
gene id: 6239:CELE_T03F1.1
uniprot id: P91430
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1.
messages: Expressed in the intestine.
messages: Interacts with ufc-1.
messages: Reduced egg laying and lifespan. Delayed larval development. Enhanced resistance to pathogens, heat and oxidative stress. Reduced survival in the presence of cadmium. Inactivation of the ufm-1 cascade.

6239:CELE F49F1.7
gene id: 6239:CELE_F49F1.7
uniprot id: Q9GZE2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y48G1A.3
gene id: 6239:CELE_Y48G1A.3
uniprot id: Q9N3Q8
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in many ciliated sensory neurons.
messages: Fails to localize guanylate cyclase gcy-12 to sensory cilia.
messages: May be involved in the trafficking and dendritic transport of signaling proteins, such as the receptor-type guanylate cyclases gcy-12 and daf-11, to the cilia. In ciliated sensory neurons, required for the calcium flux to the cytoplasm in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846).
messages: cilium

6239:CELE T28H10.1
gene id: 6239:CELE_T28H10.1
uniprot id: Q22856
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

6239:CELE Y46H3D.6
gene id: 6239:CELE_Y46H3D.6
uniprot id: A0A0K3AW28
uniprot id: Q966B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE R144.9
gene id: 6239:CELE_R144.9
uniprot id: Q9BI74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE T19H12.4
gene id: 6239:CELE_T19H12.4
uniprot id: O01609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y45F10D.9
gene id: 6239:CELE_Y45F10D.9
uniprot id: O62479
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:15572125). Required for centrosome biogenesis and duplication (PubMed:15665853, PubMed:19081077).
messages: Cytoplasm
messages: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets. Interacts with sas-5.
messages: RNAi-mediated knockdown results in failed centrosome duplication in embryos.
messages: Recruited to centrioles at the onset of the centrosome duplication cycle, then associates with the emerging daughter centriole.
messages: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring.
messages: The coiled coil domain is necessary and sufficient for interaction with sas-5.
messages: centriole

6239:CELE C17C3.18
gene id: 6239:CELE_C17C3.18
uniprot id: Q7JP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE W01A8.6
gene id: 6239:CELE_W01A8.6
uniprot id: G5EC13
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE C50E10.6
gene id: 6239:CELE_C50E10.6
uniprot id: A3QMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE R05F9.12
gene id: 6239:CELE_R05F9.12
uniprot id: Q21750
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T02B11.1
gene id: 6239:CELE_T02B11.1
uniprot id: O16974
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F52C12.5
gene id: 6239:CELE_F52C12.5
uniprot id: G5EGN3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZC155.7
gene id: 6239:CELE_ZC155.7
uniprot id: Q9TY08
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0554.5
gene id: 6239:CELE_B0554.5
uniprot id: P91003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE ZK822.5
gene id: 6239:CELE_ZK822.5
uniprot id: Q14V28
uniprot id: Q23616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

6239:CELE B0361.11
gene id: 6239:CELE_B0361.11
uniprot id: Q7Z118
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

6239:CELE F57A8.5
gene id: 6239:CELE_F57A8.5
uniprot id: Q20916
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T10G3.6
gene id: 6239:CELE_T10G3.6
uniprot id: E1B6V1
uniprot id: P92022
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

6239:CELE C16E9.4
gene id: 6239:CELE_C16E9.4
uniprot id: Q17394
uniprot id: Q8IG52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE K04G7.3
gene id: 6239:CELE_K04G7.3
uniprot id: O18158
uniprot id: Q2L6Y4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine.
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
messages: Cells lack O-GlcNAc post-translational modification and brood size decreases with increasing ambient temperature.
messages: Nucleus
messages: The TPR repeat domain mediates recognition of protein substrates.
messages: perinuclear region

6239:CELE M6.3
gene id: 6239:CELE_M6.3
uniprot id: Q21578
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Earliest expression in 4-8 cells of the pharyngeal primordium at around 280-300 min of embryonic development (PubMed:15282157). Expressed just before the comma stage (approximately 350 min) in two groups of pharyngeal primordium cells, persisting until the 3-fold stage (PubMed:15282157). At the 3-fold stage, expressed in several cells of the tail; expression continues in larvae and adults in several cells of the head, including at least two amphid neurons, intestinal cells, three rectal gland cells and 1-2 other unidentified rectal cells (PubMed:15282157).
messages: Nucleus
messages: Transcriptional repressor (By similarity). Involved in pharyngeal development and required for the formation of the pharyngeal isthmus (PubMed:15282157, PubMed:16806153). Plays a role in modulating cytoskeleton in the muscle cells of the isthmus (PubMed:16806153). Regulates expression of the acetylcholinesterase genes ace-1 and ace-2 (PubMed:16806153). May regulate its own expression (PubMed:15282157).

6239:CELE F11A5.10
gene id: 6239:CELE_F11A5.10
uniprot id: G5EBR3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.
messages: Cell membrane
messages: Glutamate binding is mediated by the extracellular domain. In contrast, the allosteric modulator ivermectin binds between subunits at the periphery of the transmembrane domain, proximal to the extracellular side.
messages: Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc-1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817). Plays a role in the regulation of locomotor behavior (PubMed:16527366).
messages: Pentamer (PubMed:21572436 and PubMed:25143115). Homooligomer, forms functional heterooligomers with glc-2 (PubMed:7935817).
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a decrease in the duration of forward locomotion in the absence of food, and an increase in the frequency of turns.

6239:CELE Y45G12C.2
gene id: 6239:CELE_Y45G12C.2
uniprot id: Q9N4X8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Responsible for approximately one-third of 4-hydroxy-2-nonenal conjugation (Ref.1, PubMed:16164425, PubMed:16300482). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).
messages: Expressed in cells at the mouth and adjacent to the pharyngeal bulbs of the head and also in the tail.
messages: Homodimer.
messages: Increase in susceptibility to 4-hydroxy-2-nonenal, paraquat and heat shock and a reduced lifespan.

6239:CELE C54E4.2
gene id: 6239:CELE_C54E4.2
uniprot id: O44466
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y22D7AR.13
gene id: 6239:CELE_Y22D7AR.13
uniprot id: G5EGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE T09E8.1
gene id: 6239:CELE_T09E8.1
uniprot id: G5EEK3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Deletion results in slower embryonic development, mutants that are 5% shorter than their wild-type conterparts, and also leads to the prevention of nuclear migration in the embryonic epidermis (PubMed:26371552, PubMed:26586219). RNAi-mediated knockdown results in fragmentation of the cadherin-based junctional complex in embryos and intermediate filaments display a diffuse pattern in older embryos (PubMed:26586219). RNAi-mediated knockdown of isoform h results in disrupted germline architecture and sterility (PubMed:26371552).
messages: Directs the assembly of non-centrosomal microtubule arrays that determine the position of nuclei within intracellular compartments in the epidermis and this is independent of ptrn-1 activity.
messages: First expressed in between seam cells at the lima-bean stage of embryogenesis (PubMed:26586219). Expressed in the embryonic epidermis and in puncta in the epidermal syncytium and also in between the epidermal body syncytium and the seam cells of larvae (PubMed:26371552).
messages: Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis (PubMed:26371552). Required for microtubule stability and anchorage by binding to microtubule minus ends (PubMed:26371552). Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules (PubMed:26586219).
messages: Required for normal nuclear migration in the embryonic epidermis.
messages: adherens junction
messages: cytoskeleton
messages: hemidesmosome

6239:CELE Y59E9AL.4
gene id: 6239:CELE_Y59E9AL.4
uniprot id: D6RYE3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C18E9.6
gene id: 6239:CELE_C18E9.6
uniprot id: Q18090
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Tom40 family.
messages: Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Interacts with mitochondrial targeting sequences.
messages: Mitochondrion outer membrane
messages: Mutants arrest during the larval developmental stage. Impaired mitochondrial homeostasis with the up-regulation of the mitochondrial unfolded protein chaperone hsp-6. RNAi-mediated knockdown results in embryonic lethality or larval lethality between the L1 and L3 stage of larval development. Surviving progeny are growth retarded. No localization of the mitochondrial targeted protein nnt-1 to the mitochondria of intestinal cells.
messages: Ubiquitously expressed, but highly expressed in the pharyngeal muscles, the nerve ring, the intestine, gonadal sheath and in the tail hypodermis.

6239:CELE C43C3.2
gene id: 6239:CELE_C43C3.2
uniprot id: I2HAC6
uniprot id: I2HAC8
uniprot id: I2HAC9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE C30D11.1
gene id: 6239:CELE_C30D11.1
uniprot id: G5EFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
messages: Cell membrane
messages: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior (PubMed:12684455).
messages: The potassium channel is composed of a homo- or heterotetrameric complex (PubMed:27916661). Interacts with dnj-1; dnj-1 chaperone promotes tetramerization (PubMed:27916661).

6239:CELE C06B8.1
gene id: 6239:CELE_C06B8.1
uniprot id: O17573
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE B0205.7
gene id: 6239:CELE_B0205.7
uniprot id: P18334
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2.
messages: Expressed in a subset of the adult male sensory neurons: CEM head neurons, ray RnB neurons, and hook HOB tail neurons.
messages: Perikaryon
messages: Tetramer of two alpha and two beta chains.
messages: axon
messages: cilium
messages: dendrite

6239:CELE PAR2.3
gene id: 6239:CELE_PAR2.3
uniprot id: P45894
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals (PubMed:15574588). Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development (PubMed:20110331). Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress (PubMed:26439621).
messages: Reduced survival as a result of hyperosmotic stress induced by NaCl. Double knockout with aak-2 results in reduced glycogen accumulation.

6239:CELE ZK892.4
gene id: 6239:CELE_ZK892.4
uniprot id: Q09618
names: Similarity
messages: Belongs to the CoA-transferase III family.

6239:CELE F59C6.2
gene id: 6239:CELE_F59C6.2
uniprot id: Q93828
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE Y54E10BR.6
gene id: 6239:CELE_Y54E10BR.6
uniprot id: Q9N3C9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.
messages: Nucleus

6239:CELE F26E4.3
gene id: 6239:CELE_F26E4.3
uniprot id: P90850
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Although strongly related to peptidase C1 family, it lacks the conserved active Cys in position 210, which is replaced by a Ser residue, suggesting that it has no protease activity.
messages: Belongs to the peptidase C1 family.
messages: Secreted

6239:CELE Y55F3AM.12
gene id: 6239:CELE_Y55F3AM.12
uniprot id: Q9N363
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DCP1 family.
messages: Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (By similarity). In contrast to orthologs, does not possess decapping activity and does not remove the 7-methyl guanine cap structure from mRNA molecules (PubMed:16199859). In the nervous system, negatively regulates the expression of insulin-like peptide ins-7, which in turn promotes longevity (PubMed:32366357). This may in part be through promoting the activity of daf-16 in distal tissues (PubMed:32366357). Required for the developmental axon guidance and regrowth of PLM touch receptor neurons (PubMed:31983639). In ADL sensory neurons, plays a role in ciliary shape formation (PubMed:28887031). Acts in neurons to promote larval survival at high temperatures by negatively regulating lin-14 expression (PubMed:28250105) (Probable).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Double RNAi-mediated knockdown with dcap-2 reduces survival at 20 degrees Celsius.
messages: Expressed in embryos (at protein level).
messages: Expressed in neurons including touch receptor neurons and motor neurons.
messages: May be a component of the decapping complex composed of dcap-1 and dcap-2.

6239:CELE Y71H9A.2
gene id: 6239:CELE_Y71H9A.2
uniprot id: Q9XWC6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

6239:CELE Y80D3A.4
gene id: 6239:CELE_Y80D3A.4
uniprot id: Q9U1R0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C18G1.6
gene id: 6239:CELE_C18G1.6
uniprot id: O61919
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F17A2.9
gene id: 6239:CELE_F17A2.9
uniprot id: O17822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y55F3AM.1
gene id: 6239:CELE_Y55F3AM.1
uniprot id: Q9N361
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE K02F3.11
gene id: 6239:CELE_K02F3.11
uniprot id: Q21155
names: Similarity
messages: Belongs to the splicing factor SR family.

6239:CELE ZK1098.7
gene id: 6239:CELE_ZK1098.7
uniprot id: P34748
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE B0416.1
gene id: 6239:CELE_B0416.1
uniprot id: A0A1N7SYS6
uniprot id: A0A1N7SYT6
uniprot id: A0A1N7SZ06
uniprot id: Q11069
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane
messages: Probable ion channel.

6239:CELE ZC168.2
gene id: 6239:CELE_ZC168.2
uniprot id: Q23247
names: Similarity
messages: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.

6239:CELE E04F6.11
gene id: 6239:CELE_E04F6.11
uniprot id: A0A0K3AR01
uniprot id: A0A0K3AR06
uniprot id: A0A0K3ARJ6
uniprot id: A0A0K3ATX5
uniprot id: A0A0K3ATY0
uniprot id: A0A0K3AUJ7
uniprot id: A0A0K3AWV4
uniprot id: Q9BMK9
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Cell membrane
messages: Expressed in excretory cell, 4 anterior epithelial cells of the intestine, hermaphrodite-specific neurons and enteric muscles (PubMed:11078724, PubMed:10567397). Expressed also in vulva and uterus (PubMed:10567397). Isoform a is expressed in oocytes (at protein level) (PubMed:11231150).
messages: Isoform a interacts (via RFLI motif) with gck-3 (via C-terminus).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phosphorylated by gck-3; phosphorylation at both Ser-742 and Ser-747 is required to inhibit channel activity (PubMed:19088383). Dephosphorylated by gsp-1/2 during cell swelling and oocyte meiotic maturation, which results in channel activation (PubMed:12163466).
messages: RNAi-mediated knockdown in oocytes results in inhibition of hyperpolarization-induced or swelling-induced current and in premature ovulatory contractions of gonadal sheath cells. Normal adaptive response to hypotonic swelling.
messages: The CBS domains, the R-helix linker (543-562) and the C-terminal domain (833-1001) regulate channel sensitivity to voltage, pH and extracellular chloride concentrations, probably by altering the outer pore structure (PubMed:16500974, PubMed:20581474). The region (738-751) between the CBS domains is essential for channel activation (PubMed:23083714).
messages: Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150). Sensitive to depolarizing conditioning voltages, requires stronger voltages for activation and activation is slower, is inhibited by low concentrations of chloride and is activated by low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974).
messages: Voltage-gated chloride channel (PubMed:10567397, PubMed:11078724, PubMed:11231150, PubMed:12163466, PubMed:15684092). Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (PubMed:14565992, PubMed:16500974). Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells (PubMed:11231150, PubMed:24431435). When active, may prevent tubular formation of the excretory canals (PubMed:18049475). Activated during oocyte meiotic maturation and by membrane hyperpolarization and cell swelling (PubMed:11231150, PubMed:14565992). Inhibited by Zn(2+) and to a lesser extent by Cd(2+)(PubMed:11231150).

6239:CELE K07A1.16
gene id: 6239:CELE_K07A1.16
uniprot id: E5QCH4
uniprot id: Q7JL16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE T14F9.1
gene id: 6239:CELE_T14F9.1
uniprot id: Q22494
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE C24F3.6
gene id: 6239:CELE_C24F3.6
uniprot id: Q9NAR3
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C02F5.1
gene id: 6239:CELE_C02F5.1
uniprot id: P34278
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed on chromosomes from early prophase until late anaphase.
messages: Interacts with hcp-3 and hcp-4 to form a complex (PubMed:14522947). Interacts with hcp-4, him-10, kbp-3, kbp-4, kbp-5, knl-3, and ndc-80 (PubMed:15371340). Interacts with kbp-1, kbp-2 and mis-12; which make up the MIS12 complex (PubMed:17129783).
messages: Perturbed spindle-kinetochore interactions, segregation defects and premature spindle elongation (PubMed:14522947, PubMed:15767665, PubMed:18070910). RNAi-mediated knockdown results in reduced localization of the spindly-like protein spdl-1 and the RZZ complex component zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Does not affect spdl-1 localization to microtubules (PubMed:18936247).
messages: Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division (PubMed:14522947, PubMed:15371340, PubMed:17129783, PubMed:18070910). Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy (PubMed:15767665, PubMed:16273096). Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores (PubMed:19109417, PubMed:20729837, PubMed:24567362).
messages: The N-terminus contains a number of repeats which contribute additively to bub-1 recruitment to unattached kinetochores. The repeats are not required for localization to kinetochores.
messages: cell cortex
messages: kinetochore

6239:CELE T25F10.5
gene id: 6239:CELE_T25F10.5
uniprot id: Q23049
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:17000880, PubMed:22022287, PubMed:22922713, PubMed:27930654). Plays a role in guanylyl cyclase localization in the ring-like structures at the base of the finger compartment in AFD sensory neurons (PubMed:25335890).
messages: Expressed from the embryonic stage to adulthood. Expressed in embryos from the 1.5-fold stage, with expression increasing to the 3-fold stage. Expressed in ciliated cells including amphid and both inner and outer labial neurons of the head at larval stages L1 and L2. Expressed in both phasmid neurons PHA and PHB in the tail and in the PDE sensory neuron in the mid-body at larval stage L3 and L4.
messages: Expressed in head and tail neurons (PubMed:15231740). Expressed in ciliated male tail-neurons (PubMed:14520415). Expressed in thermosensory and CO(2) sensory AFD neurons (PubMed:25335890).
messages: Mutants have normal body morphology, but with reduced body length and width, delayed larval development and decreased roaming movements (PubMed:22022287). May exhibit defective chemotaxis tendencies (PubMed:15231740). Defective sensory cilia structure and function (PubMed:15231740, PubMed:22022287). This is characterized by increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins such as rab-28 along the ciliary axoneme (PubMed:15231740, PubMed:27930654). Disrupted assembly of the BBSome complex at the base of the cilia (PubMed:22922713). Impaired localization of the guanylyl cyclase proteins, gcy-8, gcy-18 and gcy-23, within AFD sensory neurons, with accumulation along the dendrite as well as in the finger compartment of AFD neurons (PubMed:25335890). Thermotaxis defects and impaired tendencies to migrate to a food source (PubMed:25335890).
messages: Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9.
messages: cilium
messages: cilium axoneme
messages: cilium basal body

6239:CELE H19J13.1
gene id: 6239:CELE_H19J13.1
uniprot id: G5EDX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE Y51A2D.12
gene id: 6239:CELE_Y51A2D.12
uniprot id: Q9XXQ5
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE Y53F4B.2
gene id: 6239:CELE_Y53F4B.2
uniprot id: Q9NAC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

6239:CELE C05C8.9
gene id: 6239:CELE_C05C8.9
uniprot id: Q95X94
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HYLS1 family.
messages: Embryos do not show centriole duplication defects, are viable, and develop into fertile adults, but only 10% of the normal number of ciliated neurons are observed.
messages: Interacts with sas-4; leading to its localization into newly forming centrioles.
messages: Plays an important role in ciliogenesis (PubMed:19656802).
messages: centriole
messages: cilium

6239:CELE F13E6.5
gene id: 6239:CELE_F13E6.5
uniprot id: Q19403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

6239:CELE T16H12.5
gene id: 6239:CELE_T16H12.5
uniprot id: P34568
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Mediates ubiquitination and proteasomal degradation of target proteins, most likely in complex with cul-3 (PubMed:16740475). May promote the degradation of bromodomain-containing proteins such as bet-1 (PubMed:34593637).
messages: Nucleus
messages: Nucleus speckle
messages: RNAi-mediated knockdown suppresses the age-dependent paralysis and growth arrest induced by exogenous dipeptide repeat proteins PR50 and GR50.
messages: The BTB (POZ) domain mediates dimerization and interaction with a cullin.
messages: The MATH domain mediates interaction with protein-ubiquitin ligase substrates.

6239:CELE F56H1.4
gene id: 6239:CELE_F56H1.4
uniprot id: O76371
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including the PSMC3 homolog rpt-5 and few additional components.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:27528192). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown results in larval arrest and up-regulation of the aspartic protease ddi-1, indicative of proteasomal dysfunction. RNAi-mediated knockdown in a ddi-1, png-1, sel-11 or sel-1 mutant background results in reduced or failed expression of the proteasomal subunit rpt-3.

6239:CELE K11D12.4
gene id: 6239:CELE_K11D12.4
uniprot id: O44619
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE M01E11.2
gene id: 6239:CELE_M01E11.2
uniprot id: P91401
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK858.5
gene id: 6239:CELE_ZK858.5
uniprot id: Q94421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

6239:CELE F32D1.5
gene id: 6239:CELE_F32D1.5
uniprot id: O16294
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

6239:CELE R13A5.11
gene id: 6239:CELE_R13A5.11
uniprot id: A0A0K3AU53
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F08H9.6
gene id: 6239:CELE_F08H9.6
uniprot id: Q19229
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F55B12.4
gene id: 6239:CELE_F55B12.4
uniprot id: Q93795
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

6239:CELE F41E6.13
gene id: 6239:CELE_F41E6.13
uniprot id: O16466
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P-granules in somatic cells (PubMed:12958363, PubMed:19167332, PubMed:21183797, PubMed:21802374, PubMed:22451698, PubMed:25124690, PubMed:28557996). In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:21802374, PubMed:22451698). Plays a role in mitophagy, which is the autophagic consumption of mitochondria, in response to dietary restriction (PubMed:30133321). Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098). Also plays a role in membrane-pore repair (PubMed:27875098). In a daf-18/PTEN- and daf-16/FOXO-dependent manner, required for the proliferation of germ stem cell progenitors in the gonad during the late phases of larval development (PubMed:28285998). By regulating the release of neurotransmitters and neuropeptides, involved in the control of lifespan in response to dietary restriction and daf-2 signaling (PubMed:28557996). Probably through its involvement in autophagy, required for dauer formation (PubMed:12958363).
messages: Cytoplasm
messages: Expressed in neurons and intestinal cells.
messages: RNAi-mediated knockdown results in defective clearance of engulfed apoptotic cells (PubMed:21183797). RNAi-mediated knockdown reduces autophagic degradation of membrane pore-forming toxin Cry5B (PubMed:27875098). RNAi-mediated knockdown results in reduced germ stem cell proliferation during larval development (PubMed:28285998). RNAi-mediated knockdown causes abnormalities in constitutive dauer formation in daf-2 e1370 mutant including a lack of autophagosome formation (PubMed:12958363).
messages: The L/FRRG motif is required for recruitment to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
messages: phagosome membrane

6239:CELE K04D7.1
gene id: 6239:CELE_K04D7.1
uniprot id: Q21215
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: RNAi-mediated knockdown causes a complete loss of nlp-29 expression following fungal infection by D.coniospora and a partial reduction following physical injury.
messages: Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.

6239:CELE K08A8.3
gene id: 6239:CELE_K08A8.3
uniprot id: A0A131MBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

6239:CELE ZK177.10
gene id: 6239:CELE_ZK177.10
uniprot id: Q09376
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Knockout causes abnormal development of the pharynx, when cultured at the restrictive temperature of 23 degrees Celsius, which is exacerbated on a ceh-51 mutant background (PubMed:19605496). Embryonic arrest occurs on a ceh-51 mutant background (PubMed:19605496). Expression of homeodomain protein ceh-51 in embryo is reduced; abolished by simultaneous RNAi-mediated knockdown of pop-1 (PubMed:19605496).
messages: Nucleus
messages: Transcription factor which plays a role in mesoderm development, probably by regulating expression of target genes, such as homeobox protein ceh-51 (PubMed:19605496). Binds to DNA consensus motif 5'-[AG]T[GC][GT]CACC[TC][AGCT][AGCT][CT][CT]-3' in promoter elements (PubMed:19605496).

6239:CELE C01B7.6
gene id: 6239:CELE_C01B7.6
uniprot id: Q17551
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1 (PubMed:10839353, PubMed:15707898). Negatively regulates a p38 MAP kinase pathway composed of dlk-1, mkk-4, and pmk-3 that functions presynaptically to regulate synaptic architecture (PubMed:15707898). Has a role during synaptogenesis; regulates neuronal morphology, specifically presynaptic differentiation. May regulate the spatial arrangement of presynaptic terminals or restrict their development (PubMed:10839354, PubMed:15208641, PubMed:15707898, PubMed:21968191). By targeting both dlk-1 and mlk-1 for degradation, may negatively regulate mlk-1/mek-1/kgb-1 and dlk-1/mkk-4/pmk-3 pathways which are involved in axon regeneration after injury (PubMed:21670305). Regulates axon termination in PLM and ALM neurons (PubMed:21968191). May play a role in the formation of muscle connections between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
messages: Belongs to the RING-Cys relay (RCR) family.
messages: Expression is seen in the pharynx, coelomocytes and distal tip cell. Most abundant expression is in axons of the nerve ring neuropil. Expression is not seen in body wall muscle, hypodermis or intestine.
messages: First expressed in comma stage embryos and persists through to adulthood.
messages: In mutants, mechanosensory neurons fail to accumulate tagged vesicles, retract synaptic branches and ectopically extend axons (PubMed:10839354). Some motor neurons branch and overgrow, others show altered synaptic organization (PubMed:10839354). Fewer body wall muscle connections to target motor neurons (PubMed:27123983).
messages: Interacts with rae-1 (PubMed:22357847). Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641).
messages: The PHR domains are compact beta-sandwich folds composed of 11 antiparallel strands and decorated with conserved apical loops. They are likely to play a structural role and mediate interactions with substrates or partners (By similarity).
messages: The tandem cysteine domain region confers threonine specificity and contains the two essential catalytic cysteine residues that relay ubiquitin. It binds four zinc ions in a C5HC7HC2 configuration.
messages: axon

6239:CELE R13D11.6
gene id: 6239:CELE_R13D11.6
uniprot id: A0A0K3ASU2
uniprot id: O17010
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C05C9.1
gene id: 6239:CELE_C05C9.1
uniprot id: Q17654
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

6239:CELE K11H12.8
gene id: 6239:CELE_K11H12.8
uniprot id: P91373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

6239:CELE Y49F6B.10
gene id: 6239:CELE_Y49F6B.10
uniprot id: Q9N4U2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Expressed in hypodermal cells and seam cells, in the larval L4 stage, and in the young adult (PubMed:24569038). Not expressed in the cells of the developing vulva (PubMed:24569038).
messages: Membrane
messages: Nucleus
messages: Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle (PubMed:24569038).
messages: RNAi-mediated knockdown causes hypodermal or cuticular rupture, typically in the anterior body region (PubMed:24569038). Dumpy body shape (PubMed:24569038). Defects in cuticle integrity (PubMed:24569038).

6239:CELE K08E7.9
gene id: 6239:CELE_K08E7.9
uniprot id: P34712
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
messages: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
messages: Intestinal cells.
messages: Membrane

6239:CELE W02D9.1
gene id: 6239:CELE_W02D9.1
uniprot id: D7SFP4
uniprot id: O02334
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
messages: Heterodimer of a small subunit and a large subunit.

6239:CELE C32B5.13
gene id: 6239:CELE_C32B5.13
uniprot id: P91110
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F56F4.2
gene id: 6239:CELE_F56F4.2
uniprot id: A8DZ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C50B6.8
gene id: 6239:CELE_C50B6.8
uniprot id: P91983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T12C9.1
gene id: 6239:CELE_T12C9.1
uniprot id: Q95QB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T07D10.4
gene id: 6239:CELE_T07D10.4
uniprot id: G5ED09
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK418.9
gene id: 6239:CELE_ZK418.9
uniprot id: Q23487
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C08F11.12
gene id: 6239:CELE_C08F11.12
uniprot id: Q9U3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0375 family.
messages: Secreted

6239:CELE Y37B11A.2
gene id: 6239:CELE_Y37B11A.2
uniprot id: A0A0K3AUS7
uniprot id: A0A0K3AX87
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

6239:CELE F23B12.7
gene id: 6239:CELE_F23B12.7
uniprot id: Q19753
names: Similarity
messages: Belongs to the CBF/MAK21 family.

6239:CELE T07G12.2
gene id: 6239:CELE_T07G12.2
uniprot id: O18061
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F53H1.1
gene id: 6239:CELE_F53H1.1
uniprot id: U4PBN2
uniprot id: U4PRR4
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE Y55F3BL.2
gene id: 6239:CELE_Y55F3BL.2
uniprot id: U4PCA8
uniprot id: U4PS08
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F45E12.3
gene id: 6239:CELE_F45E12.3
uniprot id: Q17392
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cullin family.
messages: Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1.
messages: Highest levels in embryos and lower levels in larvae and adults.
messages: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
messages: Part of an E3 ubiquitin-protein ligase complex including cul-4 and ddb-1.

6239:CELE EEED8.9
gene id: 6239:CELE_EEED8.9
uniprot id: Q09298
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Mitochondrion
messages: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy (PubMed:25896323).
messages: RNAi-mediated knockdown in daf-2, isp-1, or clk-1 mutant backgrounds suppresses their increased lifespan phenotype.

6239:CELE Y105E8A.22
gene id: 6239:CELE_Y105E8A.22
uniprot id: Q8WQA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Expressed in the secretory system, hypodermis, vulva, pharyngeal muscle, rectal gland, tubular rectal epithelium cells, and tubular neuronal support cells in the head and tail.
messages: May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows.
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).
messages: Membrane
messages: Monomer.
messages: The N-terminal part (1-55) is necessary and sufficient for translocation from the cytosol to the membrane.

6239:CELE F30F8.2
gene id: 6239:CELE_F30F8.2
uniprot id: Q93650
names: Similarity
messages: Belongs to the glutaminase family.

6239:CELE F19C6.3
gene id: 6239:CELE_F19C6.3
uniprot id: Q09538
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T25B9.2
gene id: 6239:CELE_T25B9.2
uniprot id: Q27528
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F54C9.2
gene id: 6239:CELE_F54C9.2
uniprot id: Q20752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

6239:CELE T01B10.4
gene id: 6239:CELE_T01B10.4
uniprot id: O02151
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in intestine and head neurons in young adults.
messages: Nucleus
messages: Orphan nuclear receptor (PubMed:10022975). Transcriptional repressor of intestinal metal transporter smf-3 and genes of the innate immune response (PubMed:31532389). Inhibits nuclear localization of transcription factor pqm-1; in response to pathogen stress, may facilitate translocation of pqm-1, leading to transcriptional activation of genes involved in innate immunity and iron uptake (PubMed:31532389).
messages: RNAi-mediated knockdown causes enhanced resistance to infection with the Gram-negative bacterium P.aeruginosa (PubMed:31532389). Knockdown suppresses the developmental delay phenotype of hif-1 mutants when grown under iron limiting conditions (PubMed:31532389).

6239:CELE T05H4.14
gene id: 6239:CELE_T05H4.14
uniprot id: O16519
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the WD repeat GAD-1 family.
messages: Expressed maternally. Present at high level in early embryos. In adult hermaphrodites, expression is restricted to the germline.
messages: Required for initiation of gastrulation.

6239:CELE R07E5.19
gene id: 6239:CELE_R07E5.19
uniprot id: A5JYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

6239:CELE C02F5.12
gene id: 6239:CELE_C02F5.12
uniprot id: Q95QY7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T20B3.2
gene id: 6239:CELE_T20B3.2
uniprot id: Q9XUN9
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the troponin I family.
messages: Expressed in body wall muscle from first larval stage to adult. In adults expression is predominantly in vulval and anal muscles, body wall muscle expression is weaker. Also expressed in vulval muscles of hermaphrodites and the sex muscles of males.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.
messages: Worms exhibit abnormal muscle morphology, egg laying defects and constipation.

6239:CELE T23F11.5
gene id: 6239:CELE_T23F11.5
uniprot id: P46567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F13E9.13
gene id: 6239:CELE_F13E9.13
uniprot id: Q1NZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BtpA family.
messages: Mitochondrion

6239:CELE T08G11.5
gene id: 6239:CELE_T08G11.5
uniprot id: P48181
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Interacts with lev-1 (PubMed:15990870). Component of nicotinic acetylcholine receptor composed of 2 non-alpha subunits lev-1 and unc-29, and 3 alpha subunits unc-38, unc-63 and lev-8 (PubMed:15990870). Interacts with oig-4 (PubMed:21252855). Interacts with crld-1 (PubMed:30407909).
messages: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a resistance to nicotine-mediated paralysis and small impairment in mobility.

6239:CELE C09B8.6
gene id: 6239:CELE_C09B8.6
uniprot id: Q17849
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE F58G4.4
gene id: 6239:CELE_F58G4.4
uniprot id: Q20997
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:KEF34 p01
gene id: 6239:KEF34_p01
uniprot id: P24896
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

6239:CELE F54C9.5
gene id: 6239:CELE_F54C9.5
uniprot id: P49405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Nucleus

6239:CELE F11A10.1
gene id: 6239:CELE_F11A10.1
uniprot id: P54816
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure.

6239:CELE F57A8.7
gene id: 6239:CELE_F57A8.7
uniprot id: G5EBJ1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F11G11.13
gene id: 6239:CELE_F11G11.13
uniprot id: P91251
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y19D10A.11
gene id: 6239:CELE_Y19D10A.11
uniprot id: A0A0M7RDV0
uniprot id: A0A0M9JJ95
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0564.3
gene id: 6239:CELE_B0564.3
uniprot id: Q17528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE C39B10.2
gene id: 6239:CELE_C39B10.2
uniprot id: A7LPG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE ZK829.3
gene id: 6239:CELE_ZK829.3
uniprot id: Q23620
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE R10E4.9
gene id: 6239:CELE_R10E4.9
uniprot id: Q21905
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C55A6.1
gene id: 6239:CELE_C55A6.1
uniprot id: O17719
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

6239:CELE Y10G11A.3
gene id: 6239:CELE_Y10G11A.3
uniprot id: A0A078BPK5
uniprot id: Q7YTJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6239:CELE C25G6.5
gene id: 6239:CELE_C25G6.5
uniprot id: Q18179
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Could be a receptor for neuropeptide Y and peptide YY.

6239:CELE C36A4.3
gene id: 6239:CELE_C36A4.3
uniprot id: Q1HB05
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE K04G2.1
gene id: 6239:CELE_K04G2.1
uniprot id: Q21230
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: RNAi-mediated knockdown results in a reduced body length (PubMed:18635357). This phenotype in suppressed in a ced-4 n1162 mutant background (PubMed:18635357).
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).

6239:CELE C31H5.3
gene id: 6239:CELE_C31H5.3
uniprot id: B3WFZ2
uniprot id: G5EGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE D1054.15
gene id: 6239:CELE_D1054.15
uniprot id: G5ECP2
uniprot id: G5EEL2
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

6239:CELE B0213.16
gene id: 6239:CELE_B0213.16
uniprot id: O61204
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C12D5.8
gene id: 6239:CELE_C12D5.8
uniprot id: G5ECI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE W10D5.1
gene id: 6239:CELE_W10D5.1
uniprot id: Q9U325
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MEF2 family.
messages: Down-regulated by microRNA mir-1 (PubMed:18510933). Up-regulated in many head neurons during prolonged starvation (PubMed:27487365).
messages: Expressed broadly throughout most of development.
messages: Interacts with histone deacetylase hda-4 isoform b.
messages: Nucleus
messages: Transcription regulator (PubMed:17170704, PubMed:27487365). Binds specifically to the MEF2 element, 5'-[TC]TA[AT][AT][AT][AT]TA[AG]-3' in the regulatory elements of target genes, such as chemoreceptors str-1 and srh-234 (PubMed:10882527, PubMed:17170704, PubMed:27487365). Involved in transduction of sensory signals, together with egl-4, kin-29 and hda-4; binding to histone deacetylase hda-4 enables negative modulation of chemoreceptor gene expression in chemosensory neurons (PubMed:17170704, PubMed:18832350). In response to starvation, negatively modulates expression of chemoreceptor srh-234 in ADL sensory neurons, acting in concert with basic helix-loop-helix (bHLH) transcription factors (PubMed:27487365). Plays a role in regulating muscle sensitivity to acetylcholine (ACh) and the magnitude of presynaptic ACh release via a retrograde signal, perhaps by indirectly decreasing Ras-related protein Rab-3 activity (PubMed:18510933).

6239:CELE ZC317.4
gene id: 6239:CELE_ZC317.4
uniprot id: Q23076
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE JC8.3
gene id: 6239:CELE_JC8.3
uniprot id: P61866
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

6239:CELE F13A2.8
gene id: 6239:CELE_F13A2.8
uniprot id: O16890
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK1320.9
gene id: 6239:CELE_ZK1320.9
uniprot id: Q09657
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

6239:CELE F31E9.2
gene id: 6239:CELE_F31E9.2
uniprot id: O45426
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y116A8C.24
gene id: 6239:CELE_Y116A8C.24
uniprot id: H8ESG3
uniprot id: Q9U2U8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE E04A4.8
gene id: 6239:CELE_E04A4.8
uniprot id: O44480
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

6239:CELE R05H5.5
gene id: 6239:CELE_R05H5.5
uniprot id: Q21765
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

6239:CELE F58A6.10
gene id: 6239:CELE_F58A6.10
uniprot id: A0A3B1DZW5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abnormal distribution of male-derived sperm in the hermaphrodite uterus following mating, with sperm accumulating at the spermathecal-uterine valve 1 hour following mating.
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed throughout the head.
messages: G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030).
messages: Perikaryon
messages: dendrite

6239:CELE F09C6.16
gene id: 6239:CELE_F09C6.16
uniprot id: A9UJP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T28F2.6
gene id: 6239:CELE_T28F2.6
uniprot id: O01662
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C10G8.7
gene id: 6239:CELE_C10G8.7
uniprot id: Q94166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

6239:CELE C03B8.4
gene id: 6239:CELE_C03B8.4
uniprot id: Q11107
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed both maternally and zygotically.
messages: In the L3 stage, expressed in syncytial hypodermal cell 7, body wall muscles, intestinal cells, distal tip cells and many neurons.
messages: Interacts (via PLVPV motif) with chromobox protein homolog hpl-2 (via chromo (shadow subtype) domain); the interaction is direct and influences localization of hpl-2 to nuclear foci.
messages: Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism (PubMed:10880475, PubMed:16890929). May act in a common pathway with retinoblastoma-like protein homolog lin-35 and hpl-2 to influence the ER stress response in the intestine (PubMed:24715729). Plays a role in recruiting chromobox protein homolog hpl-2 to specific chromatin sites (PubMed:16890929).
messages: Nucleus
messages: RNAi-mediated knockdown causes various defects, including sterility, multiple vulvae, protruding vulva and arrested larvae (PubMed:10880475). Abolishes many hpl-2 nuclear foci (PubMed:16890929). Causes ectopic up-regulation of transcription of specific genes, such as lin-39 and lag-2 (PubMed:16890929).

6239:CELE Y40H7A.11
gene id: 6239:CELE_Y40H7A.11
uniprot id: Q9XW97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE F16A11.3
gene id: 6239:CELE_F16A11.3
uniprot id: G5ECH5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Embryonic lethal in 10 percent of animals and slight increase in the number of males produced (PubMed:19087961). In oocytes, slight increase in metaphase and anaphase meiotic spindle length, persistence of microtubules around chromatids during anaphase and delay in spindle assembly in meiosis II (PubMed:19087961, PubMed:23918937). However, localization of spindle pole marker aspm-1 and the shape of the meiotic spindle are normal (PubMed:23918937). The second polar body has a larger size and in 16 percent of animals its extrusion fails resulting in aneuploidy (PubMed:19087961). The size of the polar body is further increased in a mei-1 (or646) mutant background (PubMed:23918937). Increases mei-1 phosphorylation in a gain of function mei-1 (ct46) and tbb-2 (sb26) mutant background (PubMed:23918937). In gain of function mei-1 (ct46) mutant background, RNAi-mediated knockdown partially rescues embryonic lethality and improves embryonic mitotic spindle morphology in terms of length and orientation (PubMed:19087961).
messages: Expressed in embryos.
messages: Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits (By similarity). The catalytic subunit is likely to be pph-4.1 (PubMed:19087961). Interacts (via C-terminus) with mel-26 (probably via MATH domain); the interaction targets ppfr-1 for ubiquitin-mediated proteolysis (PubMed:23918937).

6239:CELE R03D7.1
gene id: 6239:CELE_R03D7.1
uniprot id: Q09582
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
messages: L-homocysteine is bound via the zinc atom.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity).

6239:CELE C07H6.7
gene id: 6239:CELE_C07H6.7
uniprot id: P34684
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Antp homeobox family. Deformed subfamily.
messages: Expressed in Q neuroblasts during larval development with higher expression in migrating QR.ap neuroblast descendents than in QL.ap neuroblast descendents.
messages: Interacts with nhr-25.
messages: Lin-39 and mab-5 double mutants have reduced sex myoblast specification-specific expression of sem-2 in the developing mesoderm.
messages: Nucleus
messages: Transcription factor that binds to the consensus 5'-TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression (PubMed:21307099, PubMed:23784779). Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage) (PubMed:21307099). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts (PubMed:23784779). This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development (PubMed:8101475, PubMed:23784779). Regulates vulval precursor cell (VPC) differentiation, in concert with orphan nuclear receptor nhr-25.

6239:CELE DH11.1
gene id: 6239:CELE_DH11.1
uniprot id: A0A0S4XRA9
uniprot id: Q19013
names: Similarity
messages: Belongs to the glutaminase family.

6239:CELE Y66H1A.2
gene id: 6239:CELE_Y66H1A.2
uniprot id: Q9TYJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

6239:CELE T18D3.3
gene id: 6239:CELE_T18D3.3
uniprot id: Q22541
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE C04E12.7
gene id: 6239:CELE_C04E12.7
uniprot id: G5EG07
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE ZK1225.6
gene id: 6239:CELE_ZK1225.6
uniprot id: Q9XXL3
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE F23C8.4
gene id: 6239:CELE_F23C8.4
uniprot id: Q9TXH9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in embryos, L4 larvae and adults. Expressed to a lesser extent between L1 and L3 larval stages.
messages: Expressed in the germline (at protein level) (PubMed:17498661, PubMed:20977550). Expressed in spermatocytes but not in mature sperm (at protein level) (PubMed:20977550). Ubiquitously expressed (PubMed:17498661). Predominantly expressed in the spermatheca (PubMed:17498661).
messages: Interacts with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus) in vitro; the interaction with cdc-48.1 is not detected in vivo.
messages: RNAi-mediated knockdown does not cause any visible phenotype. Simultaneous RNAi-mediated knockdown of ubxn-2 and ubxn-3, causes 50 percent embryonic lethality. The surviving hermaphrodite progeny are sterile due to a lack of sperm. Abnormal accumulation of sex determination terminal factor tra-1. Germline development is normal. In males, sperm production is normal.
messages: Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity (PubMed:20977550). Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1.
messages: perinuclear region

6239:CELE Y48E1C.1
gene id: 6239:CELE_Y48E1C.1
uniprot id: G5EBV2
uniprot id: G5EC81
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

6239:CELE K01C8.10
gene id: 6239:CELE_K01C8.10
uniprot id: P47208
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE Y18H1A.11
gene id: 6239:CELE_Y18H1A.11
uniprot id: Q8IU09
uniprot id: V6CIU7
uniprot id: V6CL91
names: Similarity
messages: Belongs to the cytidylyltransferase family.

6239:CELE ZK1290.4
gene id: 6239:CELE_ZK1290.4
uniprot id: Q5H9N3
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apparent discrepancy in expression data: a transgenic promoter based on about 4 kb from the 5' flank of the gene, drives reporter gene expression in larval L1-L4 stages, but endogenous transcripts are not detected in L1 larvae using in-situ hybridisation.
messages: Belongs to the CTF/NF-I family.
messages: Defects in locomotion, pharyngeal pumping rate, egg-laying, and reduced life-span.
messages: Expressed in muscles, neurons and intestinal cells.
messages: Expressed maternally in 2-cell embryos, zygotically in early and mid-embryogenesis; expression decreases after gastrulation and is abolished in L1 larvae, but re-expressed in the adult gonad.
messages: Nucleus
messages: Probable transcription factor which recognizes and binds the palindromic sequence 5'-TTGGCANNNTGCCAA-3' present in promoters (PubMed:16242019, PubMed:19584245). Plays a role in locomotion, pharyngeal pumping, egg-laying, and life span (PubMed:16242019, PubMed:18651662, PubMed:19584245).

6239:CELE Y87G2A.18
gene id: 6239:CELE_Y87G2A.18
uniprot id: Q7YXD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE W02C12.3
gene id: 6239:CELE_W02C12.3
uniprot id: H2KZZ2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MiT/TFE family.
messages: Cytoplasm
messages: Expressed in the intestine and at lower levels in other tissues, including the spermatheca and the vulva.
messages: Expressed throughout development (PubMed:24882217). In L4 larvae and young adults, expression is highest in the intestine, rectal epithelial cells, vulval epithelial cells, spermathecae, and pharynx and absent from the gonads (PubMed:24882217).
messages: Homodimer.
messages: Nucleus
messages: RNAi-mediated knockdown in adults reduces lifespan on eat-2, daf-2 and rsks-1 mutant backgrounds (PubMed:23925298). RNAi-mediated knockdown during the fourth larval stage reduces lifespan on a clk-1 mutant background (PubMed:23925298). RNAi-mediated knockdown reduces the expression of mml-1 on a glp-1 mutant background (PubMed:27001890). RNAi-mediated knockdown increases expression of lmp-1 and sqst-1 (PubMed:23925298).
messages: Transcription factor which regulates the expression of genes involved in lipid metabolism and autophagy in response to nutrient availability, bacterial pore-forming toxins or heat shock (PubMed:23604316, PubMed:23925298, PubMed:27001890, PubMed:27875098, PubMed:28198373). Binds to the E-box motif 5'-CACGTG-3' (PubMed:19632181). Under fasting conditions, binds to the promoter and activates the expression of lipase genes lipl-2, lipl-3 and lipl-5, and to a lesser extent, lipl-1, thereby regulating lipolysis (PubMed:23604316). Involved in modulating longevity in response to TOR signaling, dietary restriction, germline signaling, heat shock and the insulin-like signaling pathway (PubMed:23925298, PubMed:27001890, PubMed:24882217, PubMed:28198373). Involved in the immune response to infection by the S.aureus bacterium, probably acting downstream of the protein kinase dkf-1, leading to the transcriptional activation of host defense genes (PubMed:24882217, PubMed:27184844). May also play a role in lysosomal biogenesis in response to nutrient availability (PubMed:23604316).
messages: Up-regulated by fasting.

6239:CELE Y53C12A.1
gene id: 6239:CELE_Y53C12A.1
uniprot id: O18209
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation (PubMed:16338136, PubMed:16421191, PubMed:16466390). Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis (PubMed:11702779, PubMed:12397109, PubMed:27104746). Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown (PubMed:16421191).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Cytoplasm
messages: Expressed during both germline and early embryonic development. In larvae, it is expressed in the distal region, germline, and in some neurons and hypodermal cells. Not expressed in distal region of the adult.
messages: Golgi apparatus membrane
messages: Worms exhibit oocytes that mature prematurely (also known as the Emo phenotype) and chromosomes that appear condensed (PubMed:16421191). Subcellular defects include irregular perinuclear foci in oocytes (PubMed:16421191). RNAi-mediated knockdown results in an accumulation of damaged, compressed, polyploid oocytes in the uterus (PubMed:11702779). RNAi-mediated knockdown in a double oma-1 and oma-2 knockout background allows for the progression of meiosis beyond the prophase stage and oocyte maturation, but these oocytes cannot be fertilized (PubMed:11702779). RNAi-mediated knockdown in a cdc-25.2 mutant background suppresses the defect in intestinal cell divisions in the cdc-25.2 single mutant (PubMed:27104746).

6239:CELE R06F6.8
gene id: 6239:CELE_R06F6.8
uniprot id: Q09417
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIC1 family.
messages: Component of a guanine nucleotide exchange factor (GEF) complex.
messages: Membrane
messages: Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi.

6239:CELE C54F6.14
gene id: 6239:CELE_C54F6.14
uniprot id: O16453
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

6239:CELE F43G9.12
gene id: 6239:CELE_F43G9.12
uniprot id: G5EBK6
uniprot id: G5ECH1
names: Similarity
messages: Belongs to the GCF family.

6239:CELE Y54G2A.77
gene id: 6239:CELE_Y54G2A.77
uniprot id: U4PDY0
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE W04G5.5
gene id: 6239:CELE_W04G5.5
uniprot id: O18170
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE C09B9.85
gene id: 6239:CELE_C09B9.85
uniprot id: J7RNL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE T27F2.4
gene id: 6239:CELE_T27F2.4
uniprot id: Q22835
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Negatively regulated by the microRNA mir-60 (PubMed:27623524, PubMed:29664006). Induced in response to thermal stress in conditions where severe cold temperatures are followed by warmer temperatures (PubMed:29664006).
messages: Nucleus
messages: RNAi-mediated knockdown reduces the lifespan extension phenotype of the mir-60 loss of function mutant.
messages: Transcription factor that regulates the expression of genes in response to changes in temperature. In particular, binds to the promoter region of genes such as asp-17 in response to severe cold to warm temperature transitions to promote gene expression. Promotes stress-induced death, particularly in older animals, following cold shock followed by warming and this may have evolved as a form of kin survival under thermal stress conditions, favoring the survival of younger animals.

6239:CELE C25A1.7
gene id: 6239:CELE_C25A1.7
uniprot id: E2JL04
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE F22F7.4
gene id: 6239:CELE_F22F7.4
uniprot id: A0A0K3ASE9
uniprot id: A0A0K3AXR0
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C01F6.8
gene id: 6239:CELE_C01F6.8
uniprot id: G5EFZ5
uniprot id: G5EG22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

6239:CELE C03C10.4
gene id: 6239:CELE_C03C10.4
uniprot id: P42171
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SH3BP5 family.
messages: Cytoplasmic granule
messages: Expressed during embryogenesis.
messages: Expressed in germ cells.
messages: Golgi apparatus membrane
messages: Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows.
messages: Homodimer, tetramer and multimer. Interacts with rab-11.1. Binds preferentially to the GDP-bound form of rab-11.1.
messages: Viable. Disrupted localization of rab-11.1 and prolonged cytokinesis in embryos. Double knockout with rei-2 results in a smaller brood size, weak embryonic lethality, enhanced mislocalization of rab-11.1 and prolonged cytokinesis in embryos.

6239:CELE Y48E1B.12
gene id: 6239:CELE_Y48E1B.12
uniprot id: O45952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the borealin family. Highly divergent.
messages: Component of the CPC complex which consists of icp-1; csc-1; bir-1 and air-2. Within the complex interacts with Aurora B/air-2, bir-1 and icp-1.
messages: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direct the Aurora B/air-2 to centromeric DNA.
messages: Nucleus
messages: centromere
messages: spindle

6239:CELE D2045.6
gene id: 6239:CELE_D2045.6
uniprot id: Q17389
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cullin family.
messages: Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641). Interacts with Skp1-related proteins skr-1, skr-2, skr-3, skr-4, skr-7, skr-8, skr-9 and skr-10 (PubMed:11864566).
messages: Cytoplasm
messages: Highest levels in embryos and lower levels in larvae and adults.
messages: Neddylated; which enhances the ubiquitination activity of SCF.
messages: Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
messages: Ubiquitous.

6239:CELE B0272.1
gene id: 6239:CELE_B0272.1
uniprot id: P41937
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE F13B10.1
gene id: 6239:CELE_F13B10.1
uniprot id: Q5I9W0
uniprot id: Q86DA5
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SARM1 family.
messages: Cytoplasm
messages: Highly expressed in hypodermis. Localizes to postsynaptic regions of axons.
messages: Homodimer (PubMed:15048112, PubMed:27671644). Interacts with rab-1, pal-1 and unc-43 (PubMed:15048112, PubMed:15625192).
messages: NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism (PubMed:27671644). In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death (PubMed:31439792). In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development (PubMed:22363008). Required for both innate immune response and specification of AWC(OFF) neuron (PubMed:15048112, PubMed:15123841, PubMed:15625192). During late embryogenesis, it acts downstream of CAMKII (unc-43) to regulate specification of asymmetric odorant receptors in AWC(OFF) neuron via the nsy-1/ASK1 pmk-1/p38 MAP kinase signaling cascade. Required to localize nsy-1 to postsynaptic regions of AWC neuron, suggesting that it may act by assembling a signaling complex that regulate odorant receptor expression (PubMed:15625192). Also plays a central role in resistance to infection to a broad range of bacterial and fungi pathogens, possibly by activating pmk-1, independently of the NF-kappa-B pathway. Required for expression of antimicrobial peptides nlp-29 and nlp-31 (PubMed:15048112, PubMed:15123841). Its role in immune response and neuron specification may be mediated by the same nsy-1/ASK1 pmk-1/p38 MAP kinase cascade signaling pathway (PubMed:15048112, PubMed:15123841, PubMed:15625192). Involved in the response to anoxic conditions probably by activating the p38 pathway composed of nsy-1/sek-1/pmk-1 (PubMed:21212236). Involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381). In addition, plays a role in the up-regulation of gcs-1 upon arsenite treatment, most likely through activation of pmk-1, to confer protection against toxicity induced by heavy metals (PubMed:25204677).
messages: RNAi-mediated knockdown results in reduced survival and reduced pmk-1 phosphorylation in response to the heavy metal arsenite.
messages: Regulates expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.
messages: The SAM domains mediate the localization to postsynaptic regions of neurons.
messages: The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

6239:CELE C25G4.5
gene id: 6239:CELE_C25G4.5
uniprot id: G5EGE9
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the condensin I complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:19119011, PubMed:19781752). Within the complex, interacts with dpy-28, mix-1, smc-4 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:28301465). Component of the dosage compensation complex, which consists of the condensin I-like components mix-1/SMC2 and dpy-27/SMC4, and the three non SMC subunits dpy-26, capg-1 and dpy-28 (PubMed:19119011, PubMed:19781752). Within the complex, interacts with dpy-27, dpy-28, mix-1 and capg-1 (PubMed:8939870, PubMed:15557118, PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:9458050, PubMed:28301465). The interaction with dpy-27 is required for dpy-27 protein stability (PubMed:8939870). Interacts with smcl-1 (PubMed:28301465).
messages: Expressed in embryos and in somatic and germline tissues in L4 stage larvae (at protein level).
messages: Nucleus
messages: Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners (PubMed:8939869, PubMed:8939870, PubMed:19119011, PubMed:2917714, PubMed:19781752). Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis (PubMed:19119011, PubMed:19781752). As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure (PubMed:19781752, PubMed:18198337). Plays a role in robust cytokinesis upon presence of chromatin obstructions (PubMed:23684975). Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:19119011, PubMed:8939870, PubMed:2917714, PubMed:19781752). As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites (PubMed:11937488).
messages: Results in larval lethality in XX hermaphrodites; survivors exhibit shorter and stouter body morphology and are egg-laying defective (PubMed:2917714). Male animals are viable (PubMed:2917714). Higher percentage of spontaneous males through X chromosome non-disjunction (PubMed:2917714). Disrupts protein stability of dpy-27 (PubMed:8939870). Disrupts localization of dpy-28 and of capg-1 to the hermaphrodite X-chromosome (PubMed:18198337, PubMed:19119011). RNAi-mediated knockdown results in chromosome segregation defects in mitosis and meiosis (PubMed:19119011). In a sex-1 mutant background, leads to high embryonic lethality (PubMed:19119011).

6239:CELE E01H11.1
gene id: 6239:CELE_E01H11.1
uniprot id: G8JY36
uniprot id: P90980
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

6239:CELE F13A7.2
gene id: 6239:CELE_F13A7.2
uniprot id: O17800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F20D1.9
gene id: 6239:CELE_F20D1.9
uniprot id: Q93540
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE T01B7.3
gene id: 6239:CELE_T01B7.3
uniprot id: Q22045
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

6239:CELE B0403.2
gene id: 6239:CELE_B0403.2
uniprot id: Q11076
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6239:CELE C15B12.7
gene id: 6239:CELE_C15B12.7
uniprot id: A0A0K3ASM2
uniprot id: Q95QW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Expressed in intestinal cells (PubMed:12015965, PubMed:23717214). Expressed in the vulva (PubMed:12015965).
messages: Interacts with lin-45 in a zinc-dependent manner.
messages: Involved in the regulation of Pn.p cell fate determination (PubMed:12015965). Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling (PubMed:12015965). Involved in zinc transport from the intestinal lumen to the pseudocoelum (PubMed:23717214).
messages: Membrane

6239:CELE R07B5.9
gene id: 6239:CELE_R07B5.9
uniprot id: K8ERR8
names: Function
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Probable histone acetyltransferase (Probable). Required to initiate and then maintain lateralized gene expression in the ASE sensory neurons (PubMed:20923973). Involved in determining cell fate in the ASE neurons (PubMed:20923973).

6239:CELE F11C7.5
gene id: 6239:CELE_F11C7.5
uniprot id: O45346
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Expressed in VPCs and hypodermal cells during larval development (PubMed:18700817). Expressed in VPCs of L3 stage larvae prior to and during cell fate specification and in the seam cells of L1 stage larvae and adult animals (at protein level) (PubMed:18700817). Expressed in developing uterus of L4 stage larvae and in the spermatheca (at protein level) (PubMed:18700817).
messages: Expressed in coelomocytes (at protein level).
messages: May interact with lin-12/Notch receptor.
messages: Probable secreted lin-12/Notch ligand or co-ligand involved in the mediation of Notch signaling (PubMed:18700817, PubMed:21549604). Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs), acting redundantly with dsl-1 and lag-2 (PubMed:18700817). Required for normal octanol avoidance response, acting via both lin-12/Notch and glp-1/Notch signaling pathways in neurons, in concert with lag-2 (PubMed:21549604). Involved in regulation of sleep-like quiescence during the larval to adult transition, acting via Notch receptor activation and in parallel with EGF signaling (PubMed:21549604).
messages: RNAi-mediated knockdown causes moderately abnormal vulval development (PubMed:18700817). RNAi-mediated knockdown causes defects in octanol response (PubMed:21549604).

6239:CELE C16C10.2
gene id: 6239:CELE_C16C10.2
uniprot id: Q09462
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

6239:CELE R07B7.10
gene id: 6239:CELE_R07B7.10
uniprot id: Q21800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6239:CELE M142.2
gene id: 6239:CELE_M142.2
uniprot id: Q21540
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expressed in late embryos (PubMed:12921736). At the L1 larval stage and during the dauer stages, it is expressed adjacent to the lateral edges of the alae (at protein level) (PubMed:12921736). In the L2 pre-dauer stage, expressed in the head hypodermal cells hyp3, hyp4, hyp5, hyp6 and hyp7, along the main body and in tail hyp8, hyp9, hyp10 and hyp11 (PubMed:12921736). Not expressed at adult stages (at protein level) (PubMed:12921736).
messages: Plays a role in alae formation in dauer larvae probably by regulating cuticle assembly.
messages: RNAi-mediated knockdown results in shorter and fatter dauer phase animals (dumpy phenotype) (PubMed:12921736, PubMed:15936343). RNAi-mediated knockdown results in a folded pharynx in some animals (PubMed:12921736). RNAi-mediated knockdown results in no alae formation (PubMed:12921736). However, other studies indicate that RNAi-mediated knockdown results in partially formed alae (PubMed:15936343).

6239:CELE CD4.6
gene id: 6239:CELE_CD4.6
uniprot id: O44156
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE Y53C12A.3
gene id: 6239:CELE_Y53C12A.3
uniprot id: O18212
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

6239:CELE C09G5.3
gene id: 6239:CELE_C09G5.3
uniprot id: Q09233
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE F55A8.2
gene id: 6239:CELE_F55A8.2
uniprot id: O76360
uniprot id: U4PEQ9
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
messages: Binding of cGMP results in enzyme activation.
messages: Cytoplasm
messages: Expressed in AWC sensory neurons (at protein level) (PubMed:20220099). Mainly expressed in head neurons, hypodermis, intestine and body wall muscles. L2 and L3 larvae show extensive expression, lower levels are observed in L4 larvae, later embryos and adults. Isoform c is expressed in a subset of neurons in the head, nerve ring, and ventral nerve cord including some motor neurons, also in several neurons in the tail, the pharyngeal marginal cells, body muscle, intestine, vulval muscles, and spermatheca (PubMed:11181837, PubMed:12571101, PubMed:15330854).
messages: Increased size and extended lifespan (PubMed:11181837, PubMed:12571101, PubMed:18832350, PubMed:26434723). Defects in chemosensory behavior, egg-laying, synaptic transmission, and dauer formation (PubMed:11181837, PubMed:12571101, PubMed:18832350, PubMed:26434723). Impaired movement of adult animals in response to sensory stimuli (PubMed:10978280). Loss of adaptive behavior to long lasting exposure to attractive odorants (PubMed:20220099). Normal initial chemotaxis response during a first and short exposure to attractive odorants (PubMed:20220099). Loss of chemotaxis response to the repellent odor 2-nonanone (PubMed:23954825). Defective chemotaxis in response to diacetyl and isoamylalcohol (PubMed:26434723). High sensitivity to benzaldehyde, which is retained following pre-exposure in contrast to wild-type animals (PubMed:26434723). Increased basal cGMP levels (PubMed:24015261).
messages: Nucleus
messages: Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor (PubMed:18832350). Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2 (PubMed:21573134). Represses body size and lifespan through the dbl-1 and insulin pathways, respectively (PubMed:12571101, PubMed:15330854, PubMed:26434723). May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility (PubMed:12571101, PubMed:11181837, PubMed:21573134). Regulates behavioral responses to various chemosensory stimuli in sensory neurons (PubMed:10978280, PubMed:22319638, PubMed:23874221, PubMed:26434723). Required for the initiation of long term adaptation to prolonged odor exposure which results in a decrease in odor seeking behavior (PubMed:12495623, PubMed:20220099, PubMed:26434723). May regulate this process by phosphorylating tax-2, a subunit of cyclic nucleotide-gated channel tax-2/tax-4 (PubMed:12495623). In ASH sensory neurons, negatively regulates avoidance behavior to some bitter tastants, such as quinine, probably by phosphorylating rgs-2 and rgs-3 which are 2 regulator of G-protein signaling proteins (PubMed:23874221). In AWB sensory neurons, involved in avoidance behavior to some repellent odors (PubMed:23954825). In ASE left (ASEL) sensory neuron, involved in the sensing of environmental alkalinity downstream of receptor-type guanylate cyclase gcy-14 (PubMed:23664973). In sensory neurons, involved in the signaling pathway downstream of insulin, TGF-beta and receptor-type guanylate cyclase responsible for inducing quiescence after food intake (PubMed:18316030). Might play a role in aversive olfactory learning in AWC neurons when an odor is associated with food deprivation, depending on the ins-1/age-1 signal from the AIA to the AWC neurons (PubMed:27383131). Probably by regulating neuronal transmiss…
messages: When phosphorylated, interacts with saeg-2. May interact with saeg-1.

6239:CELE ZK1307.5
gene id: 6239:CELE_ZK1307.5
uniprot id: Q09363
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: F1 adults accumulate eggs in the uterus. Embryos are predominantly arrested at the bean/comma embryonic stage.
messages: Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate (PubMed:11005858). May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins (PubMed:11005858). Required for embryonic development (PubMed:9927677). Involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development (PubMed:16828468). Involved in vulval epithelium invagination (PubMed:9927677).
messages: Membrane

6239:CELE F54D8.4
gene id: 6239:CELE_F54D8.4
uniprot id: A0A131MB23
uniprot id: Q20781
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Has lost two of the three potential zinc-binding residues and therefore may not be active.
messages: Secreted

6239:CELE Y69A2AR.31
gene id: 6239:CELE_Y69A2AR.31
uniprot id: Q95XG5
names: Similarity
messages: Belongs to the GDNFR family.

6239:CELE Y48C3A.8
gene id: 6239:CELE_Y48C3A.8
uniprot id: B7FAS6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Defects in PLM neuron synaptic differentiation characterized by a misalignment of active zones and synaptic vesicles, branch point anterior to the vulva and overextension of synaptic branch. DD motoneurons display similar pre-synaptic defects. Increased expression of prk-2. In addition, mutants display a moderate uncoordinated movement, a small decrease in body size, a defect in egg laying and a slower growth.
messages: Expression begins at the 1.5-fold embryonic stage and is retained in the adult.
messages: Involved cell autonomously in PLM neuron pre-synaptic differentiation by negatively regulating prk-2 expression and in neurite branch positioning.
messages: Nucleus
messages: Ubiquitously expressed with higher expression in the head and tail ganglia, the vulva and PLM neurons.

6239:CELE Y41C4A.13
gene id: 6239:CELE_Y41C4A.13
uniprot id: Q9XWU2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell membrane
messages: Cell projection
messages: Expressed in a subset of neurons and in body wall muscles. In the nervous system, expressed specifically in cholinergic motor neurons of the ventral nerve cord, a subset of cholinergic head neurons, anterior sublateral neurons, and body sublateral neurons (at protein level).
messages: First detected in the embryo and persists throughout development (at protein level).
messages: May be involved in trafficking or stabilization of the vesicular acetylcholine transporter unc-17.
messages: Mild decrease in swimming behavior but otherwise no apparent phenotype.
messages: Perikaryon
messages: Synapse
messages: synaptic vesicle

6239:CELE T25B9.9
gene id: 6239:CELE_T25B9.9
uniprot id: Q17761
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

6239:CELE R153.1
gene id: 6239:CELE_R153.1
uniprot id: Q22000
uniprot id: Q2V4U0
uniprot id: S6FCW6
names: Cofactor
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: Expressed in dorsal D (DD) motor neurons and several other neurons at the L1 stage. Expression in DD neurons decreases gradually beginning in the late L1 stage. Highly expressed in adult ventral D (VD) motor neurons, but diminished in adult DD motor neurons.
messages: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP (PubMed:29033363).

6239:CELE F23B12.8
gene id: 6239:CELE_F23B12.8
uniprot id: G5ECF4
uniprot id: G5EGL7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE R06A4.10
gene id: 6239:CELE_R06A4.10
uniprot id: Q7JKI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F48F5.4
gene id: 6239:CELE_F48F5.4
uniprot id: Q9XV08
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F23B12.4
gene id: 6239:CELE_F23B12.4
uniprot id: A8WHS3
uniprot id: Q19751
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C55B7.4
gene id: 6239:CELE_C55B7.4
uniprot id: H2KZG6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE ZK829.5
gene id: 6239:CELE_ZK829.5
uniprot id: Q23622
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y49C4A.9
gene id: 6239:CELE_Y49C4A.9
uniprot id: Q965T7
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE K05C4.7
gene id: 6239:CELE_K05C4.7
uniprot id: Q9XUU5
names: Function
names: Subcellular Location Annotation
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

6239:CELE EGAP4.1
gene id: 6239:CELE_EGAP4.1
uniprot id: Q19077
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T25C12.3
gene id: 6239:CELE_T25C12.3
uniprot id: G5ECR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K01B6.2
gene id: 6239:CELE_K01B6.2
uniprot id: P34490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

6239:CELE T21C9.2
gene id: 6239:CELE_T21C9.2
uniprot id: D7SFN0
uniprot id: Q22639
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi.
messages: Belongs to the VPS54 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-52 and vps-53 (PubMed:21613545).
messages: Mutants are viable but display reduced brood size and enlarged lysosomes.
messages: trans-Golgi network

6239:CELE F07A11.5
gene id: 6239:CELE_F07A11.5
uniprot id: Q19133
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

6239:CELE C26E6.3
gene id: 6239:CELE_C26E6.3
uniprot id: Q18224
names: Subcellular Location Annotation
messages: P-body

6239:CELE F29F11.5
gene id: 6239:CELE_F29F11.5
uniprot id: P41936
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: First expressed prior to myogenic differentiation, expression continues throughout embryonic and larval development and is most abundant in embryos. It is present in decreasing amounts throughout development and a low level is found in the adults (PubMed:7925019). Expressed in distal tip cells (DTC) until L4 larval stage (PubMed:24346701).
messages: Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer.
messages: Nucleus
messages: RNAi-mediated knockdown in a bet-1 mutant background prevents the formation of extra distal tip cells (DTC) during gonad development.
messages: Regulates distal tip cell fate.
messages: The homeobox domain is required for the induction of distal tip cell fate.

6239:CELE M02H5.3
gene id: 6239:CELE_M02H5.3
uniprot id: Q966H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F54E7.7
gene id: 6239:CELE_F54E7.7
uniprot id: P53806
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the RCAN family.
messages: Expressed from late embryogenesis to adulthood.
messages: Expressed in lateral hypodermal cells, marginal cells of the pharynx, vulva epithelial cells, ventral and dorsal nerve cords and commissures and various neurons in the anterior and posterior regions (PubMed:12684004, PubMed:27871170). Expressed in male tail structures including the diagonal muscles, sensory rays and spicules (PubMed:12684004, PubMed:27871170). Expressed in PHC neurons and most tail neurons and support cells of the phasmid neurons (PubMed:21408209). Also expressed in pharyngeal muscle, head neurons, excretory canal cells and hypodermal seam cells (PubMed:27871170).
messages: Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions (PubMed:12684004, PubMed:26232604, PubMed:27871170). Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons (PubMed:26232604). In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1 (PubMed:26232604). May play a role in regulating body size (PubMed:27871170). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Interacts with tax-6 (via catalytic domain); the interaction is calcium-dependent.
messages: Slightly shorter body length as compared to wild-type (PubMed:27871170). Reduced calcium responses in AFD neurons upon a temperature increase from 16 to 20 degrees Celsius as compared to wild-type (PubMed:26232604). At 17 and 20 degrees Celsius displays cryophilic behavior, preferentially migrating towards colder regions (PubMed:26232604). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209).

6239:CELE F21D5.7
gene id: 6239:CELE_F21D5.7
uniprot id: G5EE80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

6239:CELE H20J04.3
gene id: 6239:CELE_H20J04.3
uniprot id: Q9N5M0
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK632.1
gene id: 6239:CELE_ZK632.1
uniprot id: P34647
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).
messages: Belongs to the MCM family.
messages: Component of the mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity).
messages: Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.
messages: Nucleus

6239:CELE W06B4.3
gene id: 6239:CELE_W06B4.3
uniprot id: Q23194
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Early endosome
messages: In hermaphrodites, expressed in coelomocytes and gonadal sheath cells.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (PubMed:25273556, PubMed:26783301). Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in intestinal cells of the embryo, and also promotes the trafficking of embryonic intestinal gut granules away from lysosomes (PubMed:24501423, PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:18923146, PubMed:26783301). Plays a role in the degradation of apoptotic cells during programmed cell death (PubMed:18923146).
messages: Probable core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, which in HOPS further associates with vps-33.1, vps-39 and vps-41 and in CORVET with vps-8 and vps-33.2.
messages: Temperature-sensitive defects in the formation of gut granules during embryogenesis (PubMed:24501423). At 15 degrees Celsius, pretzel-stage embryos have a reduced number of gut granules in intestinal cells, and at 22 degrees Celsius, pretzel-stage embryos completely lack gut granules in intestinal cells (PubMed:24501423). At 25 degrees Celsius, many embryos arrest by the pre-bean stage before elongation, and 76% of these embryos contain gut granules irregularly distributed throughout the embryo (PubMed:24501423). Defective apoptotic germ cell corpse digestion with delayed degradation of chromatin in late germ cell corpses (PubMed:18923146). This results in increased numbers of germ cell corpses at 20 degrees Celsius during embryogenesis and post the L4 stage of larval development, and furthermore the retention of cell corpses for a longer duration of time (PubMed:18923146). Impaired formation of endosomes and lysosomes in coelomocytes, in particular there is impaired formation of recycling endosomes (PubMed:18923146). In addition, there are endosome/lysosome fusion defects in coelomocytes (PubMed:18923146, PubMed:26783301). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen and large endosomes/lysosomes on the basal side of the cell (PubMed:25273556). Double knockout with either sorf-1 or sorf-2, results in larger endosomes and larger lysosomes and thus suppresses the endosome/lysosome fusion defect in the vps-18 single mutant (PubMed:26783301).
messages: Ubiquitously expressed in embryos. In early larvae, expressed in hypodermal cells, seam cells and body wall muscle cells.
messages: autophagosome
messages: clathrin-coated vesicle

6239:CELE B0414.5
gene id: 6239:CELE_B0414.5
uniprot id: O01835
names: Developmental Stage
names: Function
messages: Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis.
messages: Expressed maternally in oocytes.

6239:CELE C47A4.2
gene id: 6239:CELE_C47A4.2
uniprot id: Q2EEN3
uniprot id: Q7JKL2
uniprot id: Q9U3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE H28G03.6
gene id: 6239:CELE_H28G03.6
uniprot id: Q9TXP3
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1284 in the dsPTPase catalytic loop and does not have phosphatase activity (By similarity). The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Probably acts as an adapter for other myotubularin-like phosphatases (Probable).
messages: RNAi-mediated knockdown causes no obvious phenotype.

6239:CELE F41F3.2
gene id: 6239:CELE_F41F3.2
uniprot id: G5EDJ4
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subunit
messages: Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras (PubMed:11689700). Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma-aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol (PubMed:15990870). Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15 (PubMed:15990870). Regulates motility (PubMed:15990870). During the formation of neuromuscular junctions at the larval stage, down-regulates membrane protrusion from body wall muscles, probably downstream of egl-15 (PubMed:16495308). Promotes vulva induction and down-regulates fertility, probably downstream of receptor let-23 (PubMed:16547100). Down-regulates daf-2-mediated repression of dauer formation and positively regulates daf-2-mediated aging (PubMed:16547100). May be involved in the recruitment of phosphatase ptp-2 to egl-15 (PubMed:11689700).
messages: Causes a decrease in synaptic levels of lev-1, unc-38 and unc-49, a moderate resistance to paralysis induced by nicotine and levamisole (PubMed:15990870) and a mild increase in uncoordinated movements. In addition, forms ectopic muscle membrane extension during larval stage (PubMed:16495308). Rescues fluid accumulation in clr-1 e1745ts mutant (PubMed:11689700). Partially suppresses multi-vulva formation and partially restores fertility in let-60 1046gf mutant (PubMed:16547100). Prevents constitutive dauer formation in daf-2 m577 mutant (PubMed:16547100).
messages: Interacts (via C-terminus) with sem-5 (probably via SH3 domain 2) (PubMed:16547100). Interacts with nicotinic acetylcholine receptor (PubMed:15990870).
messages: May be phosphorylated.
messages: The C-terminal domain is required for fluid homeostasis.
messages: The PH domain is required for fluid homeostasis.

6239:CELE D2096.8
gene id: 6239:CELE_D2096.8
uniprot id: Q19007
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

6239:CELE C05D2.1
gene id: 6239:CELE_C05D2.1
uniprot id: A0A131MB12
uniprot id: A0A131MBJ8
uniprot id: G8JY02
uniprot id: P50488
uniprot id: Q8ITX8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Involved in a TGF-beta pathway (PubMed:8413626). May be a receptor for TGF-beta-like ligand daf-7 (PubMed:8413626). Controls the decision of whether or not larvae enter a developmentally arrested state, known as dauer, in response to environmental conditions (PubMed:8413626). Regulates body size and male tail patterning (PubMed:10887089, PubMed:21408209). Involved in regulating entry into quiescence triggered by satiety (PubMed:18316030). Involved in sensitivity to CO2 levels (PubMed:18524955).
messages: May interact with daf-1 to regulate dauer larva development (PubMed:10887089). Interacts with sma-10 (PubMed:20502686).
messages: Membrane
messages: Pharynx, intestine, hypodermis and body wall muscles in L1 through to adult stages. Also expressed in head neurons, ventral cord and tail neurons. Subset of head neurons show coexpression with daf-1 when dauer/nondauer decision is made.
messages: RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype).

6239:CELE E03H4.13
gene id: 6239:CELE_E03H4.13
uniprot id: O02235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:KEF34 p02
gene id: 6239:KEF34_p02
uniprot id: G5EDH4
uniprot id: P24895
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

6239:CELE R07E3.5
gene id: 6239:CELE_R07E3.5
uniprot id: Q1ZXU8
uniprot id: Q21812
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE K08B4.1
gene id: 6239:CELE_K08B4.1
uniprot id: V6CLJ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Su(H) family.
messages: Component of a complex consisting of at least a lin-12/Notch intracellular domain (NICD), lag-1, and lag-3 (PubMed:16530045, PubMed:10830967, PubMed:18381292). An NICD product of lin-12/Notch, including the RBP-j associated molecule (RAM) and ankyrin repeat (ANK) domains, interacts directly with lag-1 (PubMed:16530045, PubMed:10830967, PubMed:18381292, PubMed:9003776).
messages: Expressed in the precursor anchor cell and ventral uterine precursor cell (Z1.ppp, Z1.ppa, Z4.aaa, and Z4.aap) before cell specification, at early larval stage L2 (PubMed:23615264). Expressed in the ventral uterine cell (VU), but not in the anchor cell (AC), after specification, at late larval stage L2 (PubMed:23615264). Expressed in a dynamic pattern in the vulval precursor cells (VPCs) during vulval induction in larval stage L3 (PubMed:32839181). Expressed in somatic gonad cells, the distal tip cell (DTC), and all sheath and spermathecal cells, as well as in polyploid intestinal cells, in both the larval L4 and adult stages.
messages: In young adults, expressed in germ cells in the distal most ~10 cell diameters of the progenitor zone (PZ), and also in late pachytene, diplotene and diakinesis of oogenesis.
messages: Nucleus
messages: RNAi-mediated knockdown ectopically up-regulates expression of hlh-6 outside pharyngeal gland cells.
messages: Transcriptional regulator that plays a central role in lin-12/Notch and glp-1/Notch signaling pathways, involved in cell-cell communication that regulate a broad spectrum of cell-fate determinations (PubMed:8625826). Binds directly to the 5'-[A/G]TGGGAA-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:8625826, PubMed:18706403, PubMed:23615264, PubMed:15297877, PubMed:32196486, PubMed:21737278). Acts as a transcriptional repressor when it is not associated with Notch proteins (By similarity). When in a complex with a Notch intracellular domain (NICD) product of lin-12/Notch or glp-1/Notch, and transcription regulator lag-3, it may act as a transcriptional activator that activates transcription of target genes(PubMed:18381292, PubMed:10830967, PubMed:32196486, PubMed:9003776). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively (By similarity). Autonomously required in the germline for the stem cell fate, acting in the glp-1-dependent transcriptional activation of genes, including lst-1 and sygl-1 (PubMed:32196486). Involved in cell-fate specification during reproductive system development, by positively autoregulating its own expression, in response to lin-12/Notch signaling (PubMed:23615264, PubMed:32839181). Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons (PubMed:21737278). May repress expression of hlh-6, in a lin-12/Notch-independent manner (PubMed:18706403).

6239:CELE W03D2.4
gene id: 6239:CELE_W03D2.4
uniprot id: O02115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

6239:CELE K08E3.8
gene id: 6239:CELE_K08E3.8
uniprot id: Q9XUS2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 29 family.
messages: Component of the Mediator complex (By similarity). May interact with sel-7 and sel-8 (PubMed:15020414).
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes (By similarity). Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery (By similarity). Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Involved in development of gonad and seam cells (PubMed:19500563, PubMed:15020414). Plays a role in temporal regulation of seam cell division, probably acting as a part of the Mediator complex (PubMed:19500563).
messages: Nucleus
messages: RNAi-mediated knockdown has no effect on seam cell division or differentiation, but in a sel-7 mutant background decreases number of seam cells (PubMed:19500563). Partially suppresses the hermaphrodite gonadal development defect in a lin-12 mutant background (PubMed:15020414).

6239:CELE Y32H12A.7
gene id: 6239:CELE_Y32H12A.7
uniprot id: Q9N534
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

6239:CELE C05C12.3
gene id: 6239:CELE_C05C12.3
uniprot id: G5ECM4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y116F11B.1
gene id: 6239:CELE_Y116F11B.1
uniprot id: Q9NEK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F18H3.5
gene id: 6239:CELE_F18H3.5
uniprot id: Q9XTR1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Arrested cell division in the G1 phase during larval development (PubMed:25562820). RNAi-mediated knockdown results in L4 stage arrest which is associated with uncoordinated movements and a protruding vulva (PubMed:10518501). Impaired cell division of P blast cells, somatic gonad precursors Z1 and Z4 and intestinal cells (PubMed:10518501). Severe defect in the proliferation of P blast cells, intestinal cells, vulva cell precursors and somatic gonad precursors (PubMed:10518501). Mesoblast M cell division is normal (PubMed:10518501). Double knockout with lin-35 rescues the cell cycle progression defect in the single cdk-4 mutants (PubMed:11684669, PubMed:25562820).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Expression initiates during mid-embryogenesis primarily in post-proliferative hypodermal cells and neurons in the head, ventral cord and tail, then declines until hatching where it is mainly seen in seam cells. Expressed throughout larval development in several blast cell linages. In the P lineage, expression is restricted to proliferating cells, whereas it persists in somatic gonads and seam cells. Expressed in uterus and intestine and to a lesser extent in spermatheca.
messages: Interacts with cyd-1; the interaction is likely involved in regulating cdk-4 activity.
messages: Serine/threonine-protein kinase which, in association with cyclin D-like protein cyd-1, is required for the progression through the G1 phase of the cell cycle during postembryonic development by phosphorylating and inhibiting lin-35 and fzr-1 (PubMed:10518501, PubMed:11684669, PubMed:25562820). In complex with cyd-1, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP) (PubMed:16198291).

6239:CELE F58A4.11
gene id: 6239:CELE_F58A4.11
uniprot id: P34478
names: Disruption Phenotype
names: Subunit
messages: Interacts with gex-3.
messages: No visible phenotype.

6239:CELE Y105E8A.6
gene id: 6239:CELE_Y105E8A.6
uniprot id: Q9NEZ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Expressed during embryogenesis, in larvae and in adult animals.
messages: Expressed in the body wall muscles, vulval muscles and the anal muscles (PubMed:15210732, PubMed:20385102). Expressed in the muscle arms of the head muscle cells that form neuromuscular junctions and in the anal depressor muscle (PubMed:15210732).
messages: M line
messages: Nucleus
messages: RNAi-mediated knockdown leads to disorganized actin-containing I band filaments, disorganized dense bodies in the muscles and reduced motility.
messages: Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732, PubMed:20385102). Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting (PubMed:20385102). Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion (PubMed:15210732).
messages: Ubiquitinated. Ubiquitination by rnf-5 leads to dissociation from muscle dense bodies during molting and is required for ecdysis.
messages: focal adhesion

6239:CELE C08H9.5
gene id: 6239:CELE_C08H9.5
uniprot id: Q17833
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: By UV irradiation, high temperatures, starvation and old age.
messages: Cell membrane
messages: Increased life span and resistance to UV irradiation and high temperatures.
messages: Receptor tyrosine kinase which plays a role in promoting longevity and resistance to stresses including UV irradiation and high temperatures, probably downstream of daf-16.

6239:CELE Y54F10AL.1
gene id: 6239:CELE_Y54F10AL.1
uniprot id: H2KZK9
uniprot id: Q9BL66
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y46E12BL.2
gene id: 6239:CELE_Y46E12BL.2
uniprot id: Q965N8
names: Similarity
messages: Belongs to the RRP12 family.

6239:CELE B0491.7
gene id: 6239:CELE_B0491.7
uniprot id: Q17514
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

6239:CELE T08G11.1
gene id: 6239:CELE_T08G11.1
uniprot id: Q8T3D2
uniprot id: Q94010
names: Similarity
messages: Belongs to the VPS13 family.

6239:CELE F58B3.7
gene id: 6239:CELE_F58B3.7
uniprot id: Q20966
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

6239:CELE C36B1.1
gene id: 6239:CELE_C36B1.1
uniprot id: G5EDV5
uniprot id: G5EF89
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE Y48B6A.3
gene id: 6239:CELE_Y48B6A.3
uniprot id: Q9U299
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Expressed in the pharyngeal myoepithelium and intestine. Also expressed in several anterior neurons including the sensory neurons, as well as the interneuron PVT and the pharyngeal motorneuron M5.
messages: Expressed throughout all developmental stages. Detected in the M5 pharyngeal neuron only in larvae. Also persistently expressed in the intestine of adults past the molting stage.
messages: Interacts with paxt-1 (via N-terminus); the interaction is direct and results in stabilization of xrn-2 in the complex.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity (PubMed:19734881, PubMed:21397849). Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA (PubMed:19734881, PubMed:21397849, PubMed:26779609). Degradation role is enhanced when in complex with paxt-1 (PubMed:24462208, PubMed:26779609). Partially redundant to xrn-1 in miRNA guide strand degradation (PubMed:19734881, PubMed:21397849). Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA (PubMed:19734881, PubMed:21397849). Positively regulates molting of the pharyngeal cuticle (PubMed:16122351, PubMed:19734881).
messages: RNAi-mediated knockdown results in impaired miRNA degradation leading to accumulation of mature miRNA passenger (miR*) strands (PubMed:19734881, PubMed:21397849). Defective molting owing to failure to shed cuticle from the pharynx in the late L4-stage larvae (PubMed:16122351). Suppresses the vulval bursting phenotype of let-7 mutant (PubMed:19734881). Reduced paxt-1 expression (PubMed:24462208).
messages: Up-regulated prior to molting.

6239:CELE Y76B12C.3
gene id: 6239:CELE_Y76B12C.3
uniprot id: Q9N4C6
names: Similarity
messages: Belongs to the selenoprotein M/F family.

6239:CELE C24A1.1
gene id: 6239:CELE_C24A1.1
uniprot id: O17058
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Expressed in the ALA neuron in L4 stage larvae.
messages: Probable FMRFamide-like neuropeptides (PubMed:27546573). Plays a role in behaviors associated with a sleep-like state induced by stress (SIS), acting in concert with the FMRFamide related peptide flp-13 and neuropeptide-like protein nlp-8 (PubMed:27546573).
messages: Secreted

6239:CELE F28C1.3
gene id: 6239:CELE_F28C1.3
uniprot id: Q19857
names: Similarity
messages: Belongs to the PPP1R37 family.

6239:CELE K06C4.5
gene id: 6239:CELE_K06C4.5
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T28A8.7
gene id: 6239:CELE_T28A8.7
uniprot id: Q9XU10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

6239:CELE C04E6.9
gene id: 6239:CELE_C04E6.9
uniprot id: O01466
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F43D9.6
gene id: 6239:CELE_F43D9.6
uniprot id: B3CKG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3 homolog.
messages: Cytoplasm

6239:CELE C41G7.2
gene id: 6239:CELE_C41G7.2
uniprot id: G5ECC0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE T19H12.2
gene id: 6239:CELE_T19H12.2
uniprot id: O01615
names: Similarity
messages: Belongs to the ANP32 family.

6239:CELE R05D3.6
gene id: 6239:CELE_R05D3.6
uniprot id: P34539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L) (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

6239:CELE T02B5.3
gene id: 6239:CELE_T02B5.3
uniprot id: P92016
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE Y43B11AR.4
gene id: 6239:CELE_Y43B11AR.4
uniprot id: Q9N3X2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

6239:CELE C37H5.1
gene id: 6239:CELE_C37H5.1
uniprot id: A0A131MB16
names: Similarity
messages: Belongs to the annexin family.

6239:CELE F52H2.2
gene id: 6239:CELE_F52H2.2
uniprot id: A0A0K3AVL7
uniprot id: O17395
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C52E12.2
gene id: 6239:CELE_C52E12.2
uniprot id: P23678
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
messages: Expressed in nerve ring, amphid commissure and ventral nerve cord (at protein level).
messages: Motor protein involved in microtubule-associated anterograde transport (PubMed:1846075). Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons (PubMed:20510931). Regulates the polarized sorting of axonal proteins (PubMed:22101643). Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex (PubMed:21609829). Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons (PubMed:12657671). Involved in necrotic cell death (PubMed:22157748).
messages: Worms exhibit uncoordinated and slow movement.
messages: axon
messages: cytoskeleton

6239:CELE K12C11.7
gene id: 6239:CELE_K12C11.7
uniprot id: A4V4W7
uniprot id: W6RY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6239:CELE F17C8.9
gene id: 6239:CELE_F17C8.9
uniprot id: C0P278
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

6239:CELE F25H8.6
gene id: 6239:CELE_F25H8.6
uniprot id: Q19787
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in neuronal cell bodies in the ventral cord and HSN neurons.
messages: Expressed in the lateral hypodermal (seam) cells and occasionally in the hyp7 hypodermal cell during the larval stages of development with increased expression during the molting phase between the L3 and L4 stages of larval development. Also expressed in the vulval precursor cell desecendents of P5.p, P6.p and P7.p cells.
messages: Nucleus
messages: Probable transcription factor (PubMed:20005870, PubMed:24885717). Involved in vulval organogenesis (PubMed:20005870, PubMed:24885717). During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1 (PubMed:20005870). Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage (PubMed:24885717). Plays a role in larval molting (PubMed:20005870).
messages: RNAi-mediated knockdown results in an egg-laying defect and vulval cell-lineage defects including failed division of vulval precursor cell descendents (PubMed:20005870). RNAi-mediated knockdown causes a decrease in expression of lin-39 at the larval L3 stage (PubMed:24885717). Knockdown in L1 stage larvae, in a lin-39 mutant background, causes abnormal fusion of vulval precursor cells at larval stage L2 (PubMed:24885717).

6239:CELE Y22F5A.3
gene id: 6239:CELE_Y22F5A.3
uniprot id: A5PEW5
uniprot id: O62414
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

6239:CELE C52E4.6
gene id: 6239:CELE_C52E4.6
uniprot id: G5EBX3
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Involved in pre-mRNA splicing (By similarity). Functions in association with cyclin-dependent kinases (CDKs) (By similarity). Involved in induction of expression of heat shock protein hsp-16.2 in response to heat shock (PubMed:15611166). Plays a role in male tail development, perhaps acting together with cell cycle regulators cdc-25.2, cdk-1, cyb-3, and cyd-1 (PubMed:27923661).
messages: RNAi-mediated knockdown causes abnormal male tail morphology.

6239:CELE F42E11.2
gene id: 6239:CELE_F42E11.2
uniprot id: Q20332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Probable chloride channel.

6239:CELE F23B12.5
gene id: 6239:CELE_F23B12.5
uniprot id: Q19749
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

6239:CELE T28D6.9
gene id: 6239:CELE_T28D6.9
uniprot id: Q9U357
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PEN-2 family.
messages: Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2.
messages: Endoplasmic reticulum membrane
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
messages: Expressed from 100-cell stage in most somatic tissues, including neurons, muscle, intestine and developing vulva. Little or not expressed in early embryos.
messages: Golgi apparatus membrane

6239:CELE ZC434.9
gene id: 6239:CELE_ZC434.9
uniprot id: G3MU28
uniprot id: G3MU29
uniprot id: G3MU30
uniprot id: Q23318
uniprot id: Q7JLE3
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK896.8
gene id: 6239:CELE_ZK896.8
uniprot id: G5EFQ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed specifically in AFD sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium

6239:CELE Y38F1A.5
gene id: 6239:CELE_Y38F1A.5
uniprot id: Q9U2M5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Arrested cell division in the G1 phase during larval development (PubMed:25562820). RNAi-mediated knockdown results in an arrest at L2 stage which is associated with uncoordinated movements, a slightly shorter and stouter body morphology, growth arrest and premature death (PubMed:10518501). In addition, during larval development, cell division is impaired in P blast cells and mesoblast M cells due to an arrest prior to S phase (PubMed:10518501). Lack of cell division in somatic gonad precursors Z1 and Z4 which is associated with a failure to maintain germline proliferation resulting in an abnormal gonad development (PubMed:10518501). At the late embryonic stage, intestinal cells fail to divide without affecting endoreduplication which results in 4n DNA cellular content (PubMed:11684669). Mutants show slightly stronger defects including the development of only two enlarged embryonic coelomocytes (PubMed:11684669, PubMed:15708572). Double knockout with lin-35 rescues the cell cycle progression defect in the single cyd-1 mutant (PubMed:11684669, PubMed:25562820).
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Expression initiates during mid-embryogenesis primarily in post-proliferative hypodermal cells and neurons in the head, ventral cord and tail, then declines until hatching where it is mainly seen in seam cells. Expressed throughout larval development in several blast cell linages. In the P lineage, expression is restricted to proliferating cells, whereas it persists in somatic gonads and seam cells. In somatic gonads, expression is restricted to the spermathecal cells and their precursors. Not expressed in the intestine.
messages: In association with cdk-4, regulates the progression through the G1 phase of the cell cycle during postembryonic development (PubMed:10518501, PubMed:11684669, PubMed:25562820). Regulates proliferation of the coelomocyte lineage and intestinal cells during late embryogenesis (PubMed:15708572, PubMed:11684669). In complex with cdk-4, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP) (PubMed:16198291).
messages: Interacts with cdk-4; the interaction is likely involved in regulating cdk-4 activity (PubMed:10518501).

6239:CELE F39B2.9
gene id: 6239:CELE_F39B2.9
uniprot id: H2L2K0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y110A7A.20
gene id: 6239:CELE_Y110A7A.20
uniprot id: Q8TA52
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.
messages: cilium

6239:CELE M195.3
gene id: 6239:CELE_M195.3
uniprot id: Q21565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Involved in the uptake of ammonia.
messages: Membrane

6239:CELE K11G12.1
gene id: 6239:CELE_K11G12.1
uniprot id: Q21432
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Defects lead to retarded growth.
messages: Expressed in the anterior part of the intestine, CEP neurons and to a lesser extent in hypodermis.
messages: Metalloprotease.
messages: Secreted

6239:CELE C23H3.1
gene id: 6239:CELE_C23H3.1
uniprot id: P91082
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: During the L3 larval stage, transiently expressed in the anchor cell, in rectal epithelial cells D, VL, and VR, in B and in Y, and in several neuronal cells (PubMed:11784109). During the L4 larval stage, expressed near the vulva and the uterus, with expression lining the lumen of the uterus and portions of the vulval lumen including the vulval toroid cells vulB and vulE (PubMed:11784109). During the L4 larval stage, not expressed in the vulval toroid vulF (PubMed:11784109).
messages: Highly expressed in the cells of the spermatheca, the mouth, and the lining of the pharynx, the rectum, and the excretory canal (PubMed:11784109). Also expressed in the pharyngeal intestinal junction cell (PubMed:11784109).
messages: Putative acyltransferase (Probable). Plays a role in the morphogenesis of a vulval toroid cell, vulF, which is located where the vulva and the uterus connect (PubMed:11784109, PubMed:17560977). Not required for specifying vulval cell fate (PubMed:17560977).

6239:CELE F40F9.9
gene id: 6239:CELE_F40F9.9
uniprot id: G5EEK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE C27C7.3
gene id: 6239:CELE_C27C7.3
uniprot id: Q9XVC7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R08C7.2
gene id: 6239:CELE_R08C7.2
uniprot id: H2L0H3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum
messages: Expressed from early embryogenesis to adulthood in various cell types.
messages: Probable chaperone protein for the phospholipid-transporting ATPase tat-1. Regulates cell membrane structure and function. Plays a role in maintaining the membrane phosphatidylserine asymmetry and the formation of the tubular membrane structure. Involved in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo and this is likely with the phospholipid-transporting ATPase tat-1.
messages: RNAi-mediated knockdown results in the appearance of abnormal vacuoles in the intestines and defective recycling of endocytic cargo with the accumulation of cargo within abnormal early endosomes.
messages: Recycling endosome membrane

6239:CELE C25D7.3
gene id: 6239:CELE_C25D7.3
uniprot id: P34706
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:8431944, PubMed:11937488). Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:11937488, PubMed:14660541). Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes (PubMed:14660541, PubMed:9458050, PubMed:8939870, PubMed:9056777, PubMed:8939869).
messages: Component of the SDC complex, which consists of sdc-1, sdc-2 and sdc-3 (PubMed:11937488). Within the complex, interacts with sdc-1 and sdc-2 (PubMed:11937488). Interacts with dpy-21 (PubMed:14660541).
messages: Disrupts the X-chromosome specific localization of dpy-26, mix-1 and dpy-21.
messages: Expressed in embryonic and early larval stages and in adult animals.
messages: Expressed in somatic and in germline tissues in hermaphrodites (XX). In males (XO), only present in embryos younger than the 100-cell stage (at protein level).
messages: Nucleus
messages: Sumoylated. Sumoylation is important for assembly of the dosage compensation complex and its robust binding to the X chromosome.

6239:CELE F02D8.4
gene id: 6239:CELE_F02D8.4
uniprot id: G5EC96
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE F40F8.1
gene id: 6239:CELE_F40F8.1
uniprot id: A0A0K3ARK6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Nucleus

6239:CELE Y70G10A.2
gene id: 6239:CELE_Y70G10A.2
uniprot id: Q9XWC4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK1010.7
gene id: 6239:CELE_ZK1010.7
uniprot id: O18286
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y111B2A.18
gene id: 6239:CELE_Y111B2A.18
uniprot id: Q9NEW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the splicing factor SR family.
messages: Directly phosphorylated by spk-1 in vitro on serine residues of the RS domain.
messages: Interacts with spk-1.
messages: Nucleus
messages: Plays an essential role in embryogenesis.
messages: Predominantly coexpressed with spk-1 in adult hermaphrodite germlines.

6239:CELE C35D10.2
gene id: 6239:CELE_C35D10.2
uniprot id: Q18488
names: Similarity
messages: Belongs to the GIPC family.

6239:CELE C06A12.4
gene id: 6239:CELE_C06A12.4
uniprot id: Q9XU42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed bilaterally in ASK, ASI and ASJ sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221). Promotes the calcium flux to the cytoplasm in ASJ sensory neurons upon removal of a nitric oxide (NO) stimulus and is thereby involved in the behavioral avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F58G11.4
gene id: 6239:CELE_F58G11.4
uniprot id: D9N145
uniprot id: Q9XVL9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R07H5.2
gene id: 6239:CELE_R07H5.2
uniprot id: A0A061AL65
uniprot id: G5ECS9
uniprot id: G5EFE6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE F33D4.4
gene id: 6239:CELE_F33D4.4
uniprot id: O44186
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sphingolipid delta(4)-desaturase.
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Membrane

6239:CELE F07C4.10
gene id: 6239:CELE_F07C4.10
uniprot id: P91215
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T07H8.7
gene id: 6239:CELE_T07H8.7
uniprot id: O61898
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE E02H1.7
gene id: 6239:CELE_E02H1.7
uniprot id: Q09528
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZK1248.19
gene id: 6239:CELE_ZK1248.19
uniprot id: Q7JPD8
names: Similarity
messages: Belongs to the CTNNBIP1 family.

6239:CELE T02H6.11
gene id: 6239:CELE_T02H6.11
uniprot id: Q9N5E4
names: Similarity
messages: Belongs to the UQCRB/QCR7 family.

6239:CELE Y49E10.20
gene id: 6239:CELE_Y49E10.20
uniprot id: Q9XTT3
names: Similarity
messages: Belongs to the CD36 family.

6239:CELE F21F3.2
gene id: 6239:CELE_F21F3.2
uniprot id: P91267
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6239:CELE R05C11.3
gene id: 6239:CELE_R05C11.3
uniprot id: Q9TYP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Membrane

6239:CELE Y49F6B.4
gene id: 6239:CELE_Y49F6B.4
uniprot id: Q9N4U5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1 (PubMed:15254247).
messages: Belongs to the RED family.
messages: Detected at all stages of development, during early embryogenesis and in oocytes, in larvae and adults.
messages: Intrinsically disordered protein (Probable).
messages: Nucleus
messages: Probable component of the spliceosome (By similarity). Heterotetramer with smu-1 (PubMed:27150041). The smu-1 homodimer interacts (via the N-terminal region including the LisH and CTLH domains) with smu-2, giving rise to a heterotetramer (PubMed:15254247, PubMed:27150041).
messages: RNAi-mediated knockdown gives rise to no visible phenotype in wild-type, but suppresses the effects of unc-52 mutations.
messages: Ubiquitous.

6239:CELE Y48G1C.10
gene id: 6239:CELE_Y48G1C.10
uniprot id: Q8IU06
uniprot id: V6CJW9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

6239:CELE Y73F4A.1
gene id: 6239:CELE_Y73F4A.1
uniprot id: Q9XWC2
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F38C2.2
gene id: 6239:CELE_F38C2.2
uniprot id: O45489
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in embryos and during larval development (PubMed:16014321). Expressed strongly in cephalic sheath (CEPsh) glia at all developmental stages and in some motoneurons of the ventral cord in larvae (PubMed:18508862).
messages: Expressed in neuronal tissues of the head, including sheath cells of the cephalic sensilla (CEPsh) glia.
messages: Expression in ventral CEPsh glia is normal in knockout, but significantly reduced on a vab-3(ns157) mutant background (PubMed:18508862). RNAi-mediated knockdown causes egg-laying defects (PubMed:16014321).
messages: Nucleus
messages: Probable transcription factor that regulates the expression of dopamine receptors dop-1, dop-2 and dop-3 and thus dopamine-dependent behaviors (PubMed:18508862, PubMed:21688290). May act redundantly with hlh-31 and hlh-32 to regulate ventral CEPsh glia functions (PubMed:18508862). May play a role in chemotactic responses in larvae (PubMed:16014321, PubMed:21688290).

6239:CELE C08F11.17
gene id: 6239:CELE_C08F11.17
uniprot id: A0FLS3
names: Similarity
messages: Belongs to the UPF0375 family.

6239:CELE T06E4.3
gene id: 6239:CELE_T06E4.3
uniprot id: Q22258
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Expressed at all larval stages and is expressed at higher level in the adult.
messages: Nucleus
messages: RNAi-mediated knockdown results in DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the checkpoint response to double-strand breaks (DSBs) after ionizing radiation (IR) to induce cell cycle arrest or apoptosis via the cep-1/p53 pathway (PubMed:12747829, PubMed:16319925). In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites (PubMed:16628214).

6239:CELE T23G5.1
gene id: 6239:CELE_T23G5.1
uniprot id: Q03604
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Heterodimer of a large and a small subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the large subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity).

6239:CELE Y62F5A.1
gene id: 6239:CELE_Y62F5A.1
uniprot id: Q9U1W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE F42G8.8
gene id: 6239:CELE_F42G8.8
uniprot id: O44507
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE Y47D3A.29
gene id: 6239:CELE_Y47D3A.29
uniprot id: Q9NAH1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

6239:CELE H06I04.2
gene id: 6239:CELE_H06I04.2
uniprot id: A0A0K3AUV4
uniprot id: Q9N5N8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

6239:CELE C37H5.9
gene id: 6239:CELE_C37H5.9
uniprot id: P91137
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Defects lead to embryonic lethality in 6% of population.
messages: Expressed in hypodermis, uterus and spermatheca.
messages: Metalloprotease.
messages: Secreted

6239:CELE C09G4.1
gene id: 6239:CELE_C09G4.1
uniprot id: G5ED45
uniprot id: X5LPS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Catalyzes the acylation of sphingoid bases to form ceramides. Sphingolipids from Caenorhabditis elegans contain exclusively isosphingoid bases. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons.
messages: Membrane

6239:CELE Y71H2AM.2
gene id: 6239:CELE_Y71H2AM.2
uniprot id: Q9BL29
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

6239:CELE Y5F2A.2
gene id: 6239:CELE_Y5F2A.2
uniprot id: Q9XWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C03F11.3
gene id: 6239:CELE_C03F11.3
uniprot id: Q11124
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD36 family.
messages: Membrane

6239:CELE F53B1.2
gene id: 6239:CELE_F53B1.2
uniprot id: Q20696
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

6239:CELE F01F1.2
gene id: 6239:CELE_F01F1.2
uniprot id: Q19093
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

6239:CELE E02D9.3
gene id: 6239:CELE_E02D9.3
uniprot id: Q9TYV7
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE AH6.8
gene id: 6239:CELE_AH6.8
uniprot id: Q09206
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F47G6.4
gene id: 6239:CELE_F47G6.4
uniprot id: Q9TZI9
uniprot id: W6RY57
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: myofibril

6239:CELE F30A10.3
gene id: 6239:CELE_F30A10.3
uniprot id: Q93644
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

6239:CELE C28D4.1
gene id: 6239:CELE_C28D4.1
uniprot id: O17611
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F52F12.3
gene id: 6239:CELE_F52F12.3
uniprot id: Q9XTC6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Embryonic lethal with severely defective embryonic morphogenesis with no endoderm and excess mesoderm.
messages: Expressed in the embryo.
messages: Interacts with, and is activated by, tap-1.
messages: May be autophosphorylated.
messages: Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1.

6239:CELE H22D14.1
gene id: 6239:CELE_H22D14.1
uniprot id: G5EG35
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F11A6.2
gene id: 6239:CELE_F11A6.2
uniprot id: O62149
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE C08F8.2
gene id: 6239:CELE_C08F8.2
uniprot id: Q17828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction.
messages: Belongs to the helicase family.
messages: Mitochondrion matrix
messages: Nucleus

6239:CELE R13A5.15
gene id: 6239:CELE_R13A5.15
uniprot id: D7UU25
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C18A3.2
gene id: 6239:CELE_C18A3.2
uniprot id: Q09957
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F22E5.12
gene id: 6239:CELE_F22E5.12
uniprot id: O16709
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE ZK1127.5
gene id: 6239:CELE_ZK1127.5
uniprot id: Q23400
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).
messages: nucleolus

6239:CELE R07E5.3
gene id: 6239:CELE_R07E5.3
uniprot id: Q21831
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

6239:CELE K02B2.1
gene id: 6239:CELE_K02B2.1
uniprot id: Q21122
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.
messages: Synthesis and degradation of fructose 2,6-bisphosphate.

6239:CELE Y46G5A.2
gene id: 6239:CELE_Y46G5A.2
uniprot id: K8ES01
names: Function
names: Subcellular Location Annotation
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane

6239:CELE F48G7.8
gene id: 6239:CELE_F48G7.8
uniprot id: O44587
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y38A10A.1
gene id: 6239:CELE_Y38A10A.1
uniprot id: Q9UAX5
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE K06A1.1
gene id: 6239:CELE_K06A1.1
uniprot id: Q09585
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals develop with normal speed and go normally through the molt. They stop feeding for a normal time before each molt, but average nose speed is reduced by only about 10% and unlike wild-type, they are never immobile. The command interneurons AVA and AVE, which control backward movement, are not shut down during sleep-like behavior. Optogenetic channelrhodopsin activation of AIBs, RIBs and RIS interneurons during wake-like behavior using blue light does not trigger acute immobility and cessation of pumping in L1 larvae, instead it causes an increase in mobility (PubMed:24184105). No change in GABAergic function of neurons as unc-25 and the vesicular GABA transporter gene unc-47 are expressed normally. The expression of a neuropeptide gene flp-11 is strongly down-regulated in pretzel-stage embryos and in sleeping L4 larvae (PubMed:26949257).
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer.
messages: Expressed in five interneurons AIB, RIB and RIS.
messages: Expressed strongly during late embryogenesis and early larval development in three types of interneurons, the paired neurons AIB and RIB and the unpaired neuron RIS in the head, with the strongest expression in RIS. Expression after embryonic development decreases until the adult stage.
messages: Nucleus
messages: Regulates its own expression during larval development (PubMed:24184105). Transcriptionally regulated by transcription factor lim-6 in RIS interneuron in all developmental stages (PubMed:26949257).
messages: Transcription factor, which is required in the single sleep-active ring interneuron RIS for sleep-like behavioral quiescence induced by neuropeptide signaling in larvae (PubMed:24184105, PubMed:26949257). Regulates gene expression of sleep-inducing FMRFamide-like neuropeptide flp-11 in RIS (PubMed:26949257).

6239:CELE Y49A3A.5
gene id: 6239:CELE_Y49A3A.5
uniprot id: P52009
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE F35E8.1
gene id: 6239:CELE_F35E8.1
uniprot id: B6EU68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y49E10.6
gene id: 6239:CELE_Y49E10.6
uniprot id: Q9U281
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Highly expressed in nearly all larval and adult nuclei. Expressed only at low levels in intestine. Expressed throughout all stages of gametogenesis.
messages: Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).
messages: Nucleus
messages: Present at all embryonic stages (at protein level).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

6239:CELE T26F2.3
gene id: 6239:CELE_T26F2.3
uniprot id: A5JYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE F33A8.6
gene id: 6239:CELE_F33A8.6
uniprot id: G5EDI3
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE W03G9.1
gene id: 6239:CELE_W03G9.1
uniprot id: O44752
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C36E8.5
gene id: 6239:CELE_C36E8.5
uniprot id: P52275
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Cleaved by caspase ced-3 in vitro.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE F15A2.5
gene id: 6239:CELE_F15A2.5
uniprot id: Q19475
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F37C12.7
gene id: 6239:CELE_F37C12.7
uniprot id: Q20121
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F22D6.10
gene id: 6239:CELE_F22D6.10
uniprot id: Q19725
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE R144.6
gene id: 6239:CELE_R144.6
uniprot id: Q10000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE K01G5.1
gene id: 6239:CELE_K01G5.1
uniprot id: O17917
names: Function
messages: May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents.

6239:CELE DY3.6
gene id: 6239:CELE_DY3.6
uniprot id: O45323
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F28C6.4
gene id: 6239:CELE_F28C6.4
uniprot id: Q19870
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R148.2
gene id: 6239:CELE_R148.2
uniprot id: O17268
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

6239:CELE K01D12.11
gene id: 6239:CELE_K01D12.11
uniprot id: G5EDZ7
names: Similarity
messages: Belongs to the FAX family.

6239:CELE F54D8.2
gene id: 6239:CELE_F54D8.2
uniprot id: Q20779
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

6239:CELE Y46H3D.7
gene id: 6239:CELE_Y46H3D.7
uniprot id: Q966B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C29F4.2
gene id: 6239:CELE_C29F4.2
uniprot id: Q18303
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C43F9.8
gene id: 6239:CELE_C43F9.8
uniprot id: Q9U3M2
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F58E6.1
gene id: 6239:CELE_F58E6.1
uniprot id: Q20977
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment (PubMed:22470487).
messages: Cytoplasm
messages: Intron retention.
messages: Nucleus

6239:CELE K03D7.2
gene id: 6239:CELE_K03D7.2
uniprot id: O62300
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T05E11.5
gene id: 6239:CELE_T05E11.5
uniprot id: P49049
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1 (PubMed:15469912). Involved in embryonic and larval development (PubMed:15469912, PubMed:29137240).
messages: Belongs to the peptidase A22B family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: RNAi-mediated knockdown results in late stage embryonic and larval lethality, slow growth and pharyngeal pumping, uncoordinated movement, reduced brood size, middle body constriction, and muscle detachment (PubMed:15469912, PubMed:29137240). RNAi-mediated knockdown in L1 larvae causes incomplete cuticle shedding during molting (PubMed:15469912).
messages: The PAL motif is required for normal active site conformation.

6239:CELE T10B5.5
gene id: 6239:CELE_T10B5.5
uniprot id: Q86S29
uniprot id: Q9TZS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

6239:CELE Y47H10A.3
gene id: 6239:CELE_Y47H10A.3
uniprot id: Q9U2B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE ZK686.2
gene id: 6239:CELE_ZK686.2
uniprot id: P34668
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: Probable ATP-binding RNA helicase.

6239:CELE C17H12.14
gene id: 6239:CELE_C17H12.14
uniprot id: Q95X44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the V-ATPase E subunit family.
messages: Cytoplasm
messages: Expressed in embryos, larvae and adults (at protein level) (PubMed:12853134, PubMed:16684534). Expressed in the excretory cell, intestine and hypodermis throughout all developmental stages and in adults (at protein level) (PubMed:12853134, PubMed:16684534).
messages: Expressed in the excretory cell and syncytial hypodermal cells (at protein level) (PubMed:12853134, PubMed:16684534, PubMed:16785323). Expressed in the intestine (at protein level) (PubMed:16684534).
messages: Larvae are arrested at the L1 stage (PubMed:16684534). Larvae exhibit swollen vacuoles in the hypodermis of the head region, gradually spreading throughout the whole body (PubMed:16684534). Pharyngeal pumping ceases at L2 larval stage with many vacuoles covering the entire body (PubMed:16684534). Causes necrotic cell death in intestine and hypodermis (PubMed:16684534). RNAi-mediated knockdown causes sterility, formation of endomitotic oocytes in the proximal gonads, and impaired ovulation (PubMed:12853134). Diakinesis stage oocytes are displaced toward distal gonads (PubMed:12853134). Impaired yolk uptake by the oocytes from the pseudoceolomic cavities (PubMed:12853134, PubMed:16785323). Impaired acidification and food digestion of the intestine (PubMed:16684534). Causes an increase in the section of the excretory canal, which often has multiple lumens and abnormal whorls (PubMed:16785323). Does not affect alae formation in larvae (PubMed:16785323). Progeny is arrested at the embryonic stage or at the L1 larval stage (PubMed:12853134, PubMed:16785323). RNAi-mediated knockdown in embryos causes arrest at the one-cell stage (PubMed:12853134).
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Regulates pH homeostasis in the intestine (PubMed:16684534). Probably by regulating cytoplasmic pH, required for cell survival in the intestine and hypodermis (PubMed:16684534). Involved in receptor-mediated endocytosis (PubMed:12853134, PubMed:16785323). Involved in embryogenesis and larval development (PubMed:12853134, PubMed:16785323).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR.

6239:CELE F26E4.12
gene id: 6239:CELE_F26E4.12
uniprot id: O02621
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutathione peroxidase family.
messages: Cytoplasm
messages: May constitute a glutathione peroxidase-like protective system against oxidative stresses.

6239:CELE F10C1.7
gene id: 6239:CELE_F10C1.7
uniprot id: M1Z854
uniprot id: Q19286
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
messages: Expression is restricted to a discrete circumferential subapical layer within the intestinal terminal web (known as the 'endotube'); this layer joins directly to the apical junction complexes that connect adjacent gut cells.
messages: Lima bean stage of embryogenesis into adulthood.

6239:CELE C04F12.4
gene id: 6239:CELE_C04F12.4
uniprot id: Q9XVE9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

6239:CELE F36H2.3
gene id: 6239:CELE_F36H2.3
uniprot id: A0A1N7SYP5
uniprot id: A0A1N7SYV9
uniprot id: H2L2F0
uniprot id: H2L2F1
uniprot id: H2L2F4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C39B5.6
gene id: 6239:CELE_C39B5.6
uniprot id: Q9N5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

6239:CELE B0228.4
gene id: 6239:CELE_B0228.4
uniprot id: Q09221
names: Similarity
names: Tissue Specificity
messages: Belongs to the copine family.
messages: Expressed in body wall muscle.

6239:CELE W06G6.3
gene id: 6239:CELE_W06G6.3
uniprot id: Q9U338
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F43D2.1
gene id: 6239:CELE_F43D2.1
uniprot id: O17869
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE T03G6.2
gene id: 6239:CELE_T03G6.2
uniprot id: Q22127
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed throughout development (PubMed:16920335). First expressed in embryos from the 1.5-fold stage (PubMed:16920335). Highly expressed during the L2 stage of larval development (PubMed:16920335).
messages: Isoform b: Expressed in body wall muscle cells, pharyngeal muscles, rectal gland cells, vulval and uterine muscles and neurons in the head and ventral nerve cord (PubMed:16920335). Isoform c: Expressed in body wall muscle cells, neurons in the head, nerve ring, ventral and dorsal nerve cords and epidermal cells in the tail (PubMed:16920335).
messages: Nucleus
messages: Orphan nuclear receptor (Probable). Plays a role in morphogenesis and elongation during embryonic and larval development (PubMed:16920335). Plays a role in muscle formation and motility (PubMed:16920335, PubMed:18616929).
messages: RNAi-mediated knockdown results in arrest due to elongation and morphogenesis defects at the embryonic or larval stages in 30% of offspring (PubMed:16920335). Furthermore, embryos have highly disorganized epithelial cells (PubMed:16920335). RNAi-mediated knockdown in adults results in mis-localized or missing body wall muscle cells (PubMed:16920335).

6239:CELE F25H2.6
gene id: 6239:CELE_F25H2.6
uniprot id: Q93569
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Golgi apparatus

6239:CELE ZK430.8
gene id: 6239:CELE_ZK430.8
uniprot id: Q23490
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peroxidase family.
messages: Expressed in all adult and larval stages. Expression is cyclical and coincides with each of the larval molts, peaking at 12, 18, 24, and 30 hours post-hatching.
messages: Expressed in the hypodermal cells, specifically the head and seam/body.
messages: Gross morphological abnormalities causing larval arrest with associated molt defects and low levels of embryonic lethality. Cuticle function and integrity are also impaired.
messages: Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.

6239:CELE F43D9.5
gene id: 6239:CELE_F43D9.5
uniprot id: Q20361
names: Similarity
messages: Belongs to the TAF11 family.

6239:CELE T10E9.9
gene id: 6239:CELE_T10E9.9
uniprot id: A0A0K3AQR2
uniprot id: O01607
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE T11F9.6
gene id: 6239:CELE_T11F9.6
uniprot id: Q22398
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in uterine seam (utse) cell.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y57A10A.16
gene id: 6239:CELE_Y57A10A.16
uniprot id: Q9NA81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

6239:CELE T15D6.3
gene id: 6239:CELE_T15D6.3
uniprot id: O02315
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C28H8.9
gene id: 6239:CELE_C28H8.9
uniprot id: Q09477
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Cytoplasm
messages: Expressed throughout all embryonic and post-embryonic stages.
messages: Nucleus
messages: Probable transcription factor, involved in meiosis and stress protection.
messages: RNAi-mediated knockdown reduces expression of sod-3 (PubMed:28940692). RNAi-mediated knockdown on a cep-1 mutant background increases germ cell apoptosis (PubMed:28940692).

6239:CELE Y47G6A.12
gene id: 6239:CELE_Y47G6A.12
uniprot id: G5ED39
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Cleavage furrow
messages: Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis (PubMed:11728305, PubMed:12498686, PubMed:20116245, PubMed:21878498). Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase-anaphase transition (PubMed:25919583). Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase (PubMed:17913784, PubMed:21878498). Essential for embryonic cytokinesis by regulating rab-11-positive vesicle trafficking at the plasma membrane at the cleavage furrow and midbody (PubMed:20116245). Regulates centriole segregation during spermatocyte meiosis (PubMed:23401519). Required for embryonic anterior-posterior axis formation (PubMed:11832245).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed in embryos (at protein level).
messages: Expressed in oocytes (PubMed:17913784). Expressed in male germline (PubMed:23401519). Expressed in spermatocytes but undetectable in spermatids (at protein level) (PubMed:23401519).
messages: Forms a complex with securin-like protein ify-1 (via C-terminus) (PubMed:12498686, PubMed:23578927, PubMed:27249343, PubMed:28263324). Interaction with ify-1 stabilizes sep-1 (PubMed:27249343, PubMed:28263324). Also maintains the complex in the cytoplasm during interphase and recruits it to chromosomes during the first meiotic division (PubMed:23578927).
messages: Midbody
messages: Probably maintained in an inactive state via its interaction with securin ify-1 which acts as a pseudosubstrate thereby blocking access to the catalytic site. Upon ify-1 degradation at the onset of anaphase, sep-1 is likely to become active. In addition, interaction with ify-1 stabilizes sep-1.
messages: RNAi-mediated knockdown causes embryonic lethality where embryos are arrested at the onset of meiotic anaphase I (PubMed:11728305, PubMed:12498686, PubMed:23578927). During the first meiotic cell division, homologous chromosome segregation and formation of polar bodies are impaired, and multiple centrosomes accumulate resulting from a failure to undergo cytokinesis (PubMed:11728305, PubMed:12498686, PubMed:17913784, PubMed:20116245, PubMed:21878498). During meiotic anaphase I, impaired cortical granules exocytosis resulting in the formation of a one-layered eggshell instead of the normal three-layered eggshell (PubMed:11728305, PubMed:17913784, PubMed:21878498). In oocytes, ify-1 prematurely enters the nucleus prior to the nuclear envelope breakdown and fails to associate with chromosomes during meiosis I without affecting its spindle association (PubMed:23578927). Prevents histone H3-like cpar-1 cleavage at the onset of meiotic anaphase I and during embryonic mitosis (PubMed:25919583). In addition, in the one-cell embryo, causes defects in embryonic anterior-posterior polarization characterized by a failure of cortical association and posterior positioning of the paternal pronucleus and the mislocalization of par-2 and pie-1 (PubMed:11832245). During the first embryonic mitosis, abnormal accumulation of rab-11 at the cleavage furrow and midbody and furrow regression resulting in a failure to complete cytokinesis (PubMed:20116245).
messages: centrosome
messages: cytoskeleton
messages: spindle

6239:CELE Y119D3B.14
gene id: 6239:CELE_Y119D3B.14
uniprot id: Q95Y73
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

6239:CELE B0244.5
gene id: 6239:CELE_B0244.5
uniprot id: Q10909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. B0244 subfamily.
messages: Cell membrane

6239:CELE C26E6.2
gene id: 6239:CELE_C26E6.2
uniprot id: Q18225
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Expressed in the embryo (at protein level) (PubMed:18794349). Expressed in most embryonic cells starting at gastrulation and also in head and tail cells during the larval and adult stages (PubMed:18794349).
messages: Knockout causes a nearly wild-type phenotype, but a few young larvae have morphological abnormalities (PubMed:18794349). In a flh-1 mutant background, L1 larvae have severe morphological abnormalities and/or appear necrotic, and 100% die before reaching the L2 larval stage (PubMed:18794349). Embryos exhibit significantly lower expression of lin-14, and overexpression of micro-RNAs, including lin-4, mir-48, mir-241, and mir-34 (PubMed:18794349). In a flh-3 mutant background, embryos exhibit significant overexpression of micro-RNAs, including lin-4, mir-48, mir-230, and mir-65 (PubMed:18794349). RNAi-mediated knockdown has no obvious phenotype, but causes precocious embryonic expression of micro-RNA lin-4, when combined with simultaneous RNAi-mediated knockdown of flh-1 (PubMed:18794349).
messages: Probable transcription factor (PubMed:18794349). May bind to the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-1 and flh-3 (PubMed:18794349).

6239:CELE F47C10.4
gene id: 6239:CELE_F47C10.4
uniprot id: O01564
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C07A9.8
gene id: 6239:CELE_C07A9.8
uniprot id: P34319
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE ZC395.7
gene id: 6239:CELE_ZC395.7
uniprot id: Q9GYG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

6239:CELE T04B2.5
gene id: 6239:CELE_T04B2.5
uniprot id: G5EF58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y73E7A.4
gene id: 6239:CELE_Y73E7A.4
uniprot id: Q9GUM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Positively regulates a late step in synaptic vesicle exocytosis.
messages: cytosol

6239:CELE F39B2.4
gene id: 6239:CELE_F39B2.4
uniprot id: Q10669
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 23 family.
messages: Component of the Mediator complex (By similarity). Interacts with let-19/mdt-13.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Functions downstream of receptor let-23 and let-60/Ras during vulval induction likely by down-regulating the expression of phosphatase dep-1 and lin-12/Notch in vulva precursor cell descendants with a primary cell fate (PubMed:7557379, PubMed:15901674). Acts to repress beta-catenin target genes (PubMed:12130541). Required for asymmetric division of T-cells (PubMed:15790964). Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855).
messages: Highest levels in embryos and larvae. Expressed in vulval precursor cells at the time of vulval determination.
messages: Nucleus

6239:CELE Y37A1B.12
gene id: 6239:CELE_Y37A1B.12
uniprot id: O45271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

6239:CELE ZK792.3
gene id: 6239:CELE_ZK792.3
uniprot id: Q23594
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE F47G6.1
gene id: 6239:CELE_F47G6.1
uniprot id: Q9Y048
uniprot id: W6RR09
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Component of the dystrophin glycoprotein complex (DGC). Interacts with dys-1 and syntrophin (stn-1) to form the DGC.
messages: Cytoplasm
messages: From late embryogenesis to adulthood, expressed in neurons and muscles; particularly strong in the ventral nerve cord and in muscles of the body wall, head pharyngeal, and vulva; weaker in the intestinal muscle (at protein level).
messages: Mutants synergistically exhibit progressive myopathy. In dyb-1 and hlh-1 double mutants, there is an uncoordinated phenotype associated with some muscle degeneration. Overexpression of dyb-1 in dys-1 and hlh-1 double mutants delays, but does not prevent the onset and progression of myopathy.
messages: Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
messages: The coiled-coil domain mediates the specific interaction with dys-1.

6239:CELE F28F8.2
gene id: 6239:CELE_F28F8.2
uniprot id: O18693
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE F28E10.2
gene id: 6239:CELE_F28E10.2
uniprot id: U4PAZ4
uniprot id: U4PLF0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y4C6A.2
gene id: 6239:CELE_Y4C6A.2
uniprot id: A0A0K3AS42
uniprot id: A0A0K3AUI1
uniprot id: A0A0K3AV56
uniprot id: A0A0K3AXG3
uniprot id: A1IMB8
uniprot id: Q8MXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

6239:CELE Y46E12BL.4
gene id: 6239:CELE_Y46E12BL.4
uniprot id: U4PM56
uniprot id: U4PRE9
names: Similarity
messages: Belongs to the SPSB family.

6239:CELE ZK512.5
gene id: 6239:CELE_ZK512.5
uniprot id: P34643
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Interacts with tfg-1 (via N-terminus); the interaction is direct and is required for both the localization of tfg-1 and to maintain the distribution of sec-16A.1 at endoplasmic reticulum exit sites (ERES).
messages: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:21478858). In association with tfg-1, accumulates at ERES to positively regulate secretory cargo trafficking from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi apparatus (PubMed:21478858).
messages: RNAi-mediated knockdown abolishes localization of tfg-1 to endoplasmic reticulum exit sites (ERES).

6239:CELE T21H8.3
gene id: 6239:CELE_T21H8.3
uniprot id: Q94073
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE ZK783.2
gene id: 6239:CELE_ZK783.2
uniprot id: Q23588
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and thymidine to uracil and ribose-phosphate or thymine and deoxyribose-1-phosphate (PubMed:19645718). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Required for normal lifespan (PubMed:19645718).
messages: Expressed in hypodermis, pharynx, spermatheca and gonad.
messages: RNAi-mediated knockdown causes resistance to 5-fluorouracil (5-FU)-mediated toxicity.

6239:CELE C23G10.6
gene id: 6239:CELE_C23G10.6
uniprot id: Q9GYR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE T06C10.6
gene id: 6239:CELE_T06C10.6
uniprot id: Q22245
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F17E9.10
gene id: 6239:CELE_F17E9.10
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F30F8.8
gene id: 6239:CELE_F30F8.8
uniprot id: G5EF68
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TAF5 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs).
messages: Expressed in embryos (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:12458202). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early (PubMed:12458202). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced significantly in embryos (PubMed:12458202). Reduces expression of a range of genes, including let-858, rps-5, hsp16.2, and pes-10, but has little or no effect on expression of cki-2 and sur-5 (PubMed:12458202). Has little or no effect on levels of the TFIID subunits taf-10 and taf-4 (PubMed:12458202).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-5 (By similarity). Essential for early embryonic development, but not required for transcription of some genes; probably acts via activating transcription initiation by RNA Pol II, as part of the TFIID complex (PubMed:12458202).
messages: The gene name for this protein was previously taf-4 (PubMed:11963920). The nomenclature was changed in PMID:11963920 and so readers should take care to avoid confusion (PubMed:11963920).

6239:CELE F31C3.5
gene id: 6239:CELE_F31C3.5
uniprot id: O62193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of gins1, gins2, gins3 and gins4.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

6239:CELE C02C2.4
gene id: 6239:CELE_C02C2.4
uniprot id: P34272
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

6239:CELE F25D7.1
gene id: 6239:CELE_F25D7.1
uniprot id: Q93561
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: By endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner.
messages: Worms exhibit coelomocyte uptake defective (cup) phenotypes. Coelomocytes are scavenger cells that continuously and non-specifically endocytose fluid from the pseudocoelom (body cavity). Endocytosis by coelomocytes is not essential for growth or survival.

6239:CELE T05B4.13
gene id: 6239:CELE_T05B4.13
uniprot id: O16422
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE H06H21.10
gene id: 6239:CELE_H06H21.10
uniprot id: Q9TXV2
uniprot id: U4PBI0
uniprot id: U4PBV8
uniprot id: U4PEQ6
uniprot id: U4PRL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

6239:CELE F58G6.4
gene id: 6239:CELE_F58G6.4
uniprot id: A0A061ACH3
uniprot id: Q21005
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Expressed in a subset of cholinergic motor neurons including cholinergic motor neurons in the ventral cord, the retrovesicular ganglion and in head neurons such as the SMD, RMD motor neurons, the AVA and AVE command interneurons and the SAA neurons. Also expressed in a small number of glutamatergic neurons including the pharyngeal neurons MI and M3, the PLM neurons and a pair of neurons in the lateral ganglion.
messages: Grossly normal movement.
messages: Homopentamer (in vitro). Forms heteropentamers composed of acc-1 and acc-4 or acc-1 and acc-3. Both homopentamers and heteropentamers form functional ion channels.
messages: Membrane

6239:CELE W05H5.8
gene id: 6239:CELE_W05H5.8
uniprot id: Q5WRM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE R03G5.2
gene id: 6239:CELE_R03G5.2
uniprot id: G5EDF7
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Activated by nsy-1-mediated phosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: By B.thuringiensis pore-forming toxin Cry5B.
messages: Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1 (PubMed:11751572). May phosphorylate pmk-1 (PubMed:12142542, PubMed:16166371). Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons (PubMed:11751572, PubMed:12142542). Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection (PubMed:12142542, PubMed:18394898, PubMed:22216003). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796). Probably by promoting pmk-1-mediated activation of skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection (PubMed:22216003). Probably downstream of tir-1, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:18394898, PubMed:22308034). Regulates susceptibility of B.thuringiensis pore-forming toxin Cry5B and Cry21A (PubMed:15256590). Involved in the response to oxidative stress (PubMed:15888317, PubMed:22308034). May regulate transcription factor daf-16 localization during oxidative stress (PubMed:15888317). By phosphorylating pmk-1, regulates skn-1 localization during oxidative stress (PubMed:16166371). By phosphorylating and activating pmk-1, plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress (PubMed:22308034). Up-regulates expression of gcs-1 in intestine upon arsenite treatment (PubMed:16166371). Regulates germline proliferation in response to osmotic stress, starvation and germline apoptosis induced by heavy metals, such as Cu(2+) (PubMed:16729024, PubMed:19497412). In associatio…
messages: Expressed in linker cell in males.
messages: Interacts with nsy-1 (PubMed:11751572). Interacts with unc-16 (PubMed:11738026).
messages: Upon infection by P.aeruginosa and E.faecalis, RNAi-mediated knockdown results in a reduced up-regulation of gst-4 and gcs-1 expression (PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in the intestine during oxidative stress mediated by paraquat (PubMed:22308034). RNAi-mediated knockdown in a ced-1 mutant background causes a moderate reduction in germline cell apoptosis during oogenesis in response to oxidative and heat shock stresses. The phenotype is more severe and also affects the response to osmotic stress in a mek-1 and ced-1 mutant background (PubMed:16729024).

6239:CELE Y41D4B.5
gene id: 6239:CELE_Y41D4B.5
uniprot id: Q95Y04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

6239:CELE Y18H1A.14
gene id: 6239:CELE_Y18H1A.14
uniprot id: Q1EPL6
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F08B12.3
gene id: 6239:CELE_F08B12.3
uniprot id: B2MZB8
uniprot id: G5ECD1
uniprot id: G5EDJ1
uniprot id: H9G2R3
uniprot id: H9G2R4
uniprot id: H9G2R6
uniprot id: H9G2R7
uniprot id: Q565B7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y105C5B.9
gene id: 6239:CELE_Y105C5B.9
uniprot id: Q9NAM7
names: Function
names: Similarity
messages: Belongs to the PhyH family. PHYHD1 subfamily.
messages: Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity).

6239:CELE B0414.2
gene id: 6239:CELE_B0414.2
uniprot id: G5EFQ5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in seam cells in embryos from around 260 minutes post fertilization and in all subsequent developmental stages (PubMed:16236764, PubMed:16226243). Also expressed at the comma stage, at about 400 min, in the body wall muscle cells (PubMed:16226243). Expressed in males, in the descendant cells of the V5, V6, and T lineages, which include all the A-type neuron, the B-type neuron, and the structural cells of the male-specific sense organs, known as rays, from the mid-L3 larval stage to L4 stage (PubMed:15385167). Expressed in dopaminergic neurons at larval stage L4 (PubMed:31083672).
messages: Expressed in the intestine.
messages: Interacts with CBFbeta homolog bro-1; acts to increase the affinity and specificity of interaction of rnt-1 with DNA (PubMed:17933794). Interacts with TGF-beta pathway protein sma-4 (PubMed:15385167).
messages: May be phosphorylated by members of the p38 MAP kinase pathway.
messages: May be ubiquitinated in order to be targeted for proteasome-mediated degradation in intestinal cells.
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic lethality and missing male-specific sense organs, known as rays (PubMed:16236764). In hermaphrodites, RNAi-mediated knockdown causes a slight (5%) reduction in body length at adulthood (PubMed:16236764).
messages: Transcription factor (By similarity). Binds to regulatory DNA sequences in order to modulate transcription; negatively autoregulates its own expression, perhaps dependent upon CBF beta homolog bro-1 (PubMed:18158917). Promotes proliferation, and prevents differentiation, of seam cells, a stem cell-like lineage, acting in concert with bro-1 (PubMed:31740621). Required for controlling cell proliferation in the seam cells, perhaps by repressing expression of cyclin-dependent kinase inhibitor cki-1 (PubMed:16236764, PubMed:17933794). Inhibition of seam cell differentiation is regulated by rnt-1 and bro-1, perhaps acting upstream of pop-1, by antagonizing pop-1 repressor function (PubMed:31740621). Required for asymmetrical cell divisions in the lineage derived from a posterior embryonic seam cell, the T blast cell, and for asymmetric expression of zinc finger protein tlp-1 (PubMed:16226243). Regulates growth and male tail development (PubMed:15385167, PubMed:16236764, PubMed:16226243, PubMed:31083672). Involved in the oxidative stress response, perhaps downstream of the p38 MAP kinase pathway, and acting as part of a negative feedback loop via a transcriptional target gene, tyrosine-protein phosphatase vhp-1 (PubMed:22308034). Positively modulates dopaminergic signaling in a non-cell autonomous manner (PubMed:31083672). May be involved in TGF-beta signaling (PubMed:15385167).

6239:CELE R07B7.14
gene id: 6239:CELE_R07B7.14
uniprot id: Q21804
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE DY3.4
gene id: 6239:CELE_DY3.4
uniprot id: O45321
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

6239:CELE F08F8.8
gene id: 6239:CELE_F08F8.8
uniprot id: Q95ZW1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Expressed in two-fold stage embryos in the lateral epithelial cells (seam cells) and continues throughout all larval stages. In adults, expression becomes faint in seam cells and strong in intestinal cells. Also weakly expressed in epithelial cells of the vulva. Overall, expression appears to be restricted to certain types of epithelial cells and changes with developmental stages.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation.
messages: Reduction in brood size at adulthood. Abnormal tail structure, and loss of the T-cell derived rays, R7-R9, of the male-specific sensory rays, but ray sensory function remains intact. Combined with ykt-6 knock-down causes reduced seam cell leading to loss of ray phenotype. At cellular level, reduced expression of Golgi-resident proteins like mannosidase II, and more so in combination with ykt-6 knock-down.

6239:CELE C15C7.7
gene id: 6239:CELE_C15C7.7
uniprot id: Q18014
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 65 family.
messages: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines (PubMed:21966509). Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer (By similarity).
messages: Endoplasmic reticulum
messages: Manganese is bound to the substrate GDP-fucose, but is not required for enzyme activity.
messages: Monomer.

6239:CELE M05D6.6
gene id: 6239:CELE_M05D6.6
uniprot id: Q21525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

6239:CELE ZK455.1
gene id: 6239:CELE_ZK455.1
uniprot id: Q23500
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (PubMed:12438312). Has probably no RNA-binding activity (PubMed:12438312).
messages: Interacts with gex-3.
messages: cytosol

6239:CELE F59B1.9
gene id: 6239:CELE_F59B1.9
uniprot id: A0A168H5T6
uniprot id: G5EG88
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Betaine receptor that functions as a ligand-gated non-selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.
messages: Cell membrane
messages: Expressed in the body wall muscles that are arranged into four longitudinal bundles, some mechanosensory neurons, the head muscles and multiple interneurons. Not expressed in motor neurons (at protein level).
messages: Membrane
messages: Mutant worms are morphologically similar to the wild-type but exhibit mild swimming defects and are lethargic with their movement being interrupted by frequent pauses when crawling on a food-free environment (PubMed:24212673). On the same environment, in other occasions they display decreased rates of spontaneous reversal and steering, and slightly increased average speed (PubMed:23950710). Homozygotes are fully resistant to monepantel but heterozygotes are partially affected by the drug with reduced fertility and slightly impaired movement.
messages: Not expressed in embryos and L1 stage but expressed from L2 stage to adulthood in the body wall muscles (at protein level).
messages: Suppresses snf-3 mutant phenotype growth defects. Elicits no current in response to the broad-spectrum antiparasitic medicine ivermectin. This channel is allosterically sensitive to monepantel, an anthelmintic of the amino-acetonitrile derivatives (AADs) class, leading to muscle paralysis upon treatment with monepantel.

6239:CELE ZK721.1
gene id: 6239:CELE_ZK721.1
uniprot id: Q9GYF0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Sequence Caution
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SID1 family.
messages: Cell membrane
messages: Cholesterol-binding protein which is involved in dietary cholesterol uptake from the environment (PubMed:22479487). Does not play a role in double-stranded RNA transport in contrast to other SID1 family members (PubMed:29025917, PubMed:18201385).
messages: Expressed in the embryo, larva and adult with no difference in expression level across larval stages and adult.
messages: Highly expressed along the intestine with expression also detected in the pharynx, especially at the terminal bulb, and in the excretory gland cells.
messages: Hypersensitivity to cholesterol availability and decreased cholesterol uptake (PubMed:22479487). When grown in low cholesterol conditions, 72% reduction in offspring number compared to 25% reduction in wild-type worms, 60% reduction in oocyte number, altered oocyte distribution in 47% of mutants, and 5-fold increase in embryonic lethality (PubMed:22479487). In addition, in low cholesterol conditions, growth of mutants ceases by day 3, resulting in a 63% reduction in adult size at day 5, there is a 22% reduction in the number of L1 larvae that reach adulthood and a 4-5 hour delay in the L4-to-adult transition (PubMed:22479487). 78% reduction in dauer formation, increased sensitivity of adult hermaphrodites to heat exposure and reduced speed of movement independent of cholesterol availability (PubMed:22479487). Mutants show a twitching phenotype upon administration of unc-22 feeding RNAi, indicating a lack of involvement in the systemic RNAi response (PubMed:18201385). RNAi-mediated knockdown results in decreased cholesterol uptake and, when grown in low-cholesterol conditions, altered oocyte distribution in 42% of mutants, reduced oocyte numbers and reduced speed (PubMed:22479487).
messages: Probable cloning artifact.

6239:CELE B0222.4
gene id: 6239:CELE_B0222.4
uniprot id: Q17456
names: Similarity
messages: Belongs to the group II decarboxylase family.

6239:CELE Y116A8C.27
gene id: 6239:CELE_Y116A8C.27
uniprot id: Q9U2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

6239:CELE Y39B6A.17
gene id: 6239:CELE_Y39B6A.17
uniprot id: Q7YXC6
uniprot id: Q8MYP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T23G4.1
gene id: 6239:CELE_T23G4.1
uniprot id: G5EGF8
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: First expressed at the beginning of gastrulation at about 100 minutes; reduces in the anterior of the embryo at about 260 minutes, but persists and increases in the posterior embryo (PubMed:11880358). Expressed in comma-stage embryo in P neuroblasts and the mother cells of V5 and Q neuroblasts (PubMed:28716930). During larval development, expressed in the tail tip cells in hermaphrodites and males, and asymmetrically in descendants of the T cell lineage (PubMed:11880358).
messages: Nucleus
messages: Probable transcription factor that regulates development of the tail phasmid sensory organs (PubMed:11880358). Involved in migration and differentiation of lateral neuroblasts (PubMed:28716930). Involved in control of cell fate in the T cell lineage (PubMed:11880358).

6239:CELE C14F11.1
gene id: 6239:CELE_C14F11.1
uniprot id: Q17994
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6239:CELE R07G3.6
gene id: 6239:CELE_R07G3.6
uniprot id: Q09423
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed during larval development and strongly down-regulated in adults.
messages: Expressed in the hypodermal syncitium but not in hypodermal seam cells.
messages: Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23.
messages: Normal physiological responses to hypertonic stress, such as accumulation of organic osmolytes and activation of osmoresponsive genes, are constitutively activated with mutants exhibiting resistance to normally lethal levels of hypertonic stress.
messages: Secreted

6239:CELE K03H1.4
gene id: 6239:CELE_K03H1.4
uniprot id: P34500
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F42F12.4
gene id: 6239:CELE_F42F12.4
uniprot id: Q20340
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

6239:CELE F13B12.5
gene id: 6239:CELE_F13B12.5
uniprot id: G5EFY8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted

6239:CELE Y18D10A.8
gene id: 6239:CELE_Y18D10A.8
uniprot id: Q9XW13
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds to ife-3 using a bipartite interface in the C-terminal domain which comprises a canonical helix which engages the ife-3 dorsal surface and a non-canonical helix which engages the ife-3 lateral surface.
messages: Cytoplasm
messages: Interacts with eukaryotic translation initiation factor ife-3.
messages: Plays a role in promoting translation.

6239:CELE ZK180.4
gene id: 6239:CELE_ZK180.4
uniprot id: Q23445
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Also plays a role in transporting the tyrosine kinase receptor let-23 from the endoplasmic reticulum to the plasma membrane of vulval precursor cells (PubMed:32053105).
messages: RNAi-mediated knockdown results in the reduced plasma membrane localization and intracellular accumulation of the tyrosine kinase receptor let-23 in vulval precursor cells.

6239:CELE Y66A7A.8
gene id: 6239:CELE_Y66A7A.8
uniprot id: O45291
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C14C10.1
gene id: 6239:CELE_C14C10.1
uniprot id: Q17970
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE Y71H2AM.11
gene id: 6239:CELE_Y71H2AM.11
uniprot id: Q9BL46
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

6239:CELE F08D12.1
gene id: 6239:CELE_F08D12.1
uniprot id: P91240
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA) in presence of srpa-68 (By similarity). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Heterodimer with srpa-68 (By similarity). Srpa-68-srpa-72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity). Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and ZK512.4/SRP9 (By similarity). Within the SRP complex, interacts (via N-terminus) with srpa-68 (via C-terminus) (By similarity).

6239:CELE T02G5.9
gene id: 6239:CELE_T02G5.9
uniprot id: Q22099
uniprot id: Q95ZQ3
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: Cytoplasm
messages: Homodimer.
messages: It is likely that the same gene provides both this cytoplasmic isoform and an additional mitochondrial isoform.
messages: RNAi-mediated knockdown results in an arrest at an early larval stage. In adults, causes a 80 percent reduction in progeny size and a 50 percent increase in eIF2alpha phosphorylation.

6239:CELE F59F3.4
gene id: 6239:CELE_F59F3.4
uniprot id: G5EFH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE Y55F3AR.1
gene id: 6239:CELE_Y55F3AR.1
uniprot id: Q9N356
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C42C1.8
gene id: 6239:CELE_C42C1.8
uniprot id: A3QMB7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T23F2.4
gene id: 6239:CELE_T23F2.4
uniprot id: Q22701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Membrane

6239:CELE H39E23.1
gene id: 6239:CELE_H39E23.1
uniprot id: Q9TW45
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Asymmetrically localized to the posterior of the zygote before mitotic division, then differentially distributed to the germline precursor cells (at protein level).
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ.
messages: Maternally expressed.
messages: Phosphorylated at Thr-325 probably by par-4.
messages: Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:7758115). Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote (PubMed:18842813). Regulates mes-1 expression during early embryogenesis (PubMed:11003841). Critical role in postembryonic vulval morphogenesis (PubMed:12490197). Involved in the establishment of neuronal polarity (PubMed:20023164).
messages: cell cortex

6239:CELE C09G5.2
gene id: 6239:CELE_C09G5.2
uniprot id: Q09454
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the dph-1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph-1 subunit (By similarity).

6239:CELE R05G6.7
gene id: 6239:CELE_R05G6.7
uniprot id: Q21752
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of membrane-spanning sided beta-sheets.
messages: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules (By similarity). Plays a role in maintaining mitochondrial morphology (PubMed:25190516).
messages: Mitochondrion outer membrane
messages: RNAi-mediated knockdown results in a hyper-connected mitochondrial network in body wall muscle cells.

6239:CELE Y87G2A.11
gene id: 6239:CELE_Y87G2A.11
uniprot id: Q9U1Q0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the WD repeat EIPR1 family.
messages: Cytoplasm
messages: Defective egg-laying and slow, but coordinated locomotion when stimulated. Reduced levels of both unprocessed and processed luminal and transmembrane cargo in the motor neuron axons of the dorsal nerve cord. Double knockout with either rab-2, rund-1 or vps-50 results in reduced levels of both unprocessed and processed luminal and transmembrane cargo in the motor neuron axons of the dorsal nerve cord.
messages: Expressed in the hypodermis and the pharynx.
messages: Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the endosome-associated recycling protein (EARP) complex. Important for neuronal function.
messages: The subcellular location of endogenous eipr-1 could not be identified; diffuse expression of a eipr-1 construct in the cytoplasm may be an artifact due to over-expression of the construct.

6239:CELE Y32B12C.2
gene id: 6239:CELE_Y32B12C.2
uniprot id: Q9XX07
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R13A1.9
gene id: 6239:CELE_R13A1.9
uniprot id: Q7YXH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE R53.4
gene id: 6239:CELE_R53.4
uniprot id: Q22021
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE F53H1.3
gene id: 6239:CELE_F53H1.3
uniprot id: O45074
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Recycling endosome

6239:CELE ZC21.2
gene id: 6239:CELE_ZC21.2
uniprot id: P34586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.
messages: Could mediate calcium entry and form a calcium permeant channel.
messages: Membrane

6239:CELE K11E4.3
gene id: 6239:CELE_K11E4.3
uniprot id: Q21427
names: Similarity
messages: Belongs to the paraoxonase family.

6239:CELE K07D8.1
gene id: 6239:CELE_K07D8.1
uniprot id: Q21281
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abundant at hypodermal cell-matrix junctions overlying muscle of threefold embryos. Expression continues in body wall muscle in larvae and adults and is also detected in other regions where cells show mechanical attachment to the hypodermis including the inner surface of the pharynx, overlying anal and intestinal muscles, overlying vulval and uterine sex muscles, male tail muscle attachment zones and the six mechanosensory neurons (at protein level).
messages: Arrested embryonic development either at bean or twofold stages with failure of hypodermis to enclose the embryo or at threefold stage with defects in hypodermal cell organization and muscle cell positioning. When disrupted in larvae, causes paralysis and displacement of muscles.
messages: Cell membrane
messages: Expression detected in embryo, larva and adult.
messages: Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos.
messages: cytoskeleton
messages: hemidesmosome

6239:CELE C34C12.3
gene id: 6239:CELE_C34C12.3
uniprot id: Q09496
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic subunit of protein phosphatase 6 (PP6) (By similarity). In complex with saps-1, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning (PubMed:20040490). Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5 (PubMed:20040490).
messages: Cytoplasm
messages: Expressed in embryos.
messages: Forms a complex composed of catalytic subunit pph-6 and regulatory subunit saps-1; the interaction increases pph-6 and saps-1 protein stability.
messages: RNAi-mediated knockdown causes lethality in 17 percent of animals. In the 1-cell embryo, cortical contractions are severely reduced and the pseudocleavage furrow is absent. Positioning of the spindle is abnormal due to reduced pulling forces that prevent oscillatory movements of the posterior spindle pole during anaphase. In 15 percent of animals, causes defects in chromosome segregation resulting in daughter cells with multiple nuclei.
messages: cell cortex
messages: cytoskeleton
messages: spindle pole

6239:CELE Y47D3A.11
gene id: 6239:CELE_Y47D3A.11
uniprot id: Q9U2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

6239:CELE F52F12.6
gene id: 6239:CELE_F52F12.6
uniprot id: O02274
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MYT1 family.
messages: Expressed throughout embryonic development, but rarely expressed in lineages that do not produce neurons (PubMed:31386623). First expressed in neural precursors at the mid-gastrula stage of embryogenesis (PubMed:31386623). Highly expressed during the late gastrula to lima-bean embryonic stages, but weakly expressed in subsequent embryonic stages (PubMed:31386623). Post hatching, expressed in few neuronal nuclei and transiently expressed in postembryonic neuroectoblasts (PubMed:31386623). Not expressed in postmitotic neurons (PubMed:31386623). In L1 larvae, expressed in neurons and glia, but not in non-neuronal precursors (PubMed:31386623). In L2 stage larvae, expressed in the rectal epithelial Y cell (PubMed:31386623).
messages: Interacts with MuvB corepressor complex components lin-9, lin-52 and rba-1; the interaction is required to suppress the activation of non-neuronal genes in neurons (PubMed:31386623). Interacts with sin-3; the interaction is weak (PubMed:31386623).
messages: Knockout in the rectal epithelial Y cell results in impaired formation of the PDA motor neuron (PubMed:31386623). Knockout in Pn lineages (the precursor cells of the ventral epidermis of newly hatched animals) results in the defective formation of ventral cord motor neurons (PubMed:31386623).
messages: Nucleus
messages: Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis (PubMed:31386623). Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623). Required for the generation of postembryonic neurons from epidermal cells (PubMed:31386623).

6239:CELE F16B4.11
gene id: 6239:CELE_F16B4.11
uniprot id: A0A0K3AXP8
uniprot id: O44637
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y51H1A.6
gene id: 6239:CELE_Y51H1A.6
uniprot id: B7FAS0
names: Disruption Phenotype
names: Function
messages: Enhances the cell death defect of ced-3(n2427) mutants. Double knockout with the synthetic multivulva (synMuv) class B proteins lin-9, lin-15B, lin-35 or lin-54 results in 100% lethality during the L1 stage of larval development. Double knockout with the synMuv class B protein lin-53 results in slow larval growth.
messages: Promotes programmed cell death. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways.

6239:CELE T14E8.3
gene id: 6239:CELE_T14E8.3
uniprot id: Q6RYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the neurons of the head, ventral cord and tail with weak expression observed in body wall muscles and PVD neurons (PubMed:15378064). In the ventral cord, expressed strongly in GABAergic neurons with weaker expression in cholinergic motor neurons (PubMed:15378064). Expressed in cholinergic SIA neurons and octopaminergic RIC neurons (PubMed:19609300). In males, expressed in the dorsal and ventral spicule protractor and retractor muscles, and the sensory post-cloacal sensilla B (PCB) neuron (PubMed:23166505).
messages: G-protein coupled receptor which binds to the neurotransmitter dopamine with high affinity leading to the activation of an associated G-protein and downstream signaling pathways (PubMed:15378064, PubMed:16001968). Couples to G-proteins to inhibit adenylate cyclase (AC) activity and cAMP production (PubMed:15378064, PubMed:16001968). Antagonizes the D1-like dopamine receptor dop-1 to negatively regulate the rate of locomotion (PubMed:15378064). In GABAergic, RIC, and SIA neurons, antagonizes the function of dop-1 to play a role in behavioral plasticity and regulate the decision-making process when conflicting alternatives are present (PubMed:25536037). Antagonizes octopamine signaling in response to food by promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons (PubMed:19609300). This is most likely in association with the G(o)-alpha G-protein subunit goa-1 (PubMed:19609300). Promotes male mating behavior by antagonizing acetylcholine signaling to control the protrusion of copulatory spicules from the tail of males during hermaphrodite vulval location (PubMed:23166505).

6239:CELE K06B4.11
gene id: 6239:CELE_K06B4.11
uniprot id: O17933
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K04F1.15
gene id: 6239:CELE_K04F1.15
uniprot id: Q9TXM0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE Y37A1C.1
gene id: 6239:CELE_Y37A1C.1
uniprot id: E9P897
uniprot id: E9P898
uniprot id: G5EEQ4
uniprot id: G5EFE5
uniprot id: H8ESD4
uniprot id: H8ESD5
uniprot id: L8E912
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K06A1.5
gene id: 6239:CELE_K06A1.5
uniprot id: Q09406
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat tipD family.
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in neurons, pharyngeal muscles, body wall muscle cells and intestinal cells.
messages: Expressed throughout development.
messages: Homodimer (via N-terminus) (PubMed:24185444). Most likely a component of a complex at least containing atg-5, lgg-3, atg-16.1 and/or atg-16.2 (Probable). Interacts (via N-terminus) with atg-16.1 (via N-terminus) (PubMed:24185444). Interacts (via N-terminus) with atg-5 (PubMed:24185444). Interacts (via WD 5-6 repeats) with lgg-2; the interaction is direct (PubMed:26687600).
messages: Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation (PubMed:24185444, PubMed:26687600). Plays a role in the recruitment of lipidated lgg-1 probably to the autophagosome membrane to promote autophagosome formation (PubMed:24185444). Furthermore, association with atg-5 is required for the nucleation of lgg-1 positive autophagosomes (PubMed:24185444). Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.1 to regulate autophagic processes (PubMed:24185444, PubMed:28285998). In a daf-18/PTEN- and daf-16/FOXO-dependent manner, required for maintaining the numbers of germ stem cell progenitors in the gonad during the late phases of larval development (PubMed:28285998).

6239:CELE Y40B10A.2
gene id: 6239:CELE_Y40B10A.2
uniprot id: A0A0K3AT05
uniprot id: Q965W3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6239:CELE F35B12.8
gene id: 6239:CELE_F35B12.8
uniprot id: Q20015
names: Similarity
messages: Belongs to the globin family.

6239:CELE Y39A1A.14
gene id: 6239:CELE_Y39A1A.14
uniprot id: Q9XX15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.
messages: nucleolus

6239:CELE K07B1.4
gene id: 6239:CELE_K07B1.4
uniprot id: O01881
uniprot id: Q86FS9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F40F9.2
gene id: 6239:CELE_F40F9.2
uniprot id: Q20241
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

6239:CELE B0035.10
gene id: 6239:CELE_B0035.10
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F46F3.4
gene id: 6239:CELE_F46F3.4
uniprot id: Q9XVN3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iASPP family.
messages: Interacts with cep-1/p53; the interaction inhibits pro-apoptotic activity of cep-1.
messages: Negetively regulates apoptosis via its interaction with cep-1.
messages: Nucleus
messages: RNAi-mediated knockdown results in an increase in number of apoptotic germ cells (PubMed:12524540). Double RNAi-mediated knockdown together with cep-1 abrogates this increased number of apoptotic germ cells (PubMed:12524540).

6239:CELE K04G11.5
gene id: 6239:CELE_K04G11.5
uniprot id: A0A1C3NSL2
uniprot id: A0A1C3NSP8
uniprot id: A0A1C3NSR4
uniprot id: A0A1C3NSS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

6239:CELE F31C3.4
gene id: 6239:CELE_F31C3.4
uniprot id: O62192
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F35D11.3
gene id: 6239:CELE_F35D11.3
uniprot id: Q20035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

6239:CELE T21B4.17
gene id: 6239:CELE_T21B4.17
uniprot id: Q5FC44
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F59A2.4
gene id: 6239:CELE_F59A2.4
uniprot id: P52874
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

6239:CELE C11H1.4
gene id: 6239:CELE_C11H1.4
uniprot id: G5ED99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

6239:CELE Y69H2.12
gene id: 6239:CELE_Y69H2.12
uniprot id: Q9U1T8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C33H5.17
gene id: 6239:CELE_C33H5.17
uniprot id: Q18418
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription repressor.

6239:CELE E04D5.4
gene id: 6239:CELE_E04D5.4
uniprot id: G5ECJ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C26D10.1
gene id: 6239:CELE_C26D10.1
uniprot id: Q18211
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
messages: Key component of the Ran GTPase system, which comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.
messages: Loss of ran-3 causes low levels of chromosomes to misalign on the metaphase plate and segregate incorrectly in early embryonic cell divisions.
messages: Nucleus

6239:CELE F45E1.6
gene id: 6239:CELE_F45E1.6
uniprot id: Q10453
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Highly expressed in all adult nuclei.
messages: Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression (By similarity).
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

6239:CELE ZK858.4
gene id: 6239:CELE_ZK858.4
uniprot id: Q94420
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in body wall muscles.
messages: I band
messages: Interacts (via BTB domain) with cul-3 (PubMed:13679922, PubMed:14528312, PubMed:22621901). Seems to be a component of a E3 ubiquitin-protein ligase complex containing cul-3 (PubMed:13679922, PubMed:14528312). Interacts (probably via MATH domain) with mei-1, which targets mei-1 for ubiquitin-mediated proteolysis (PubMed:14528312, PubMed:22621901, PubMed:23918937). Interacts (probably via MATH domain) with ppfr-1, the regulatory subunit of the PP4 complex; targets ppfr-1 for ubiquitin-mediated proteolysis (PubMed:23918937). May interact (via MATH domain) with unc-89 (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) (PubMed:22621901).
messages: M line
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312, PubMed:13679922, PubMed:23918937). Controls degradation of microtubule severing protein mei-1 after meiosis (PubMed:14528312). Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis (PubMed:23918937). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89 (PubMed:22621901). May also activate the TORC1 pathway (PubMed:29769719).
messages: RNAi-mediated knockdown at L1 larval stage results in the disorganization of myosin thick filaments in adult body wall muscles characterized by the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A-bands (PubMed:22621901). RNAi-mediated knockdown of mel-26 also results in increased lifespan (PubMed:29769719).

6239:CELE F59A7.9
gene id: 6239:CELE_F59A7.9
uniprot id: O16284
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

6239:CELE Y39C12A.3
gene id: 6239:CELE_Y39C12A.3
uniprot id: A0A061AIZ9
uniprot id: A0A067XG43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T05A10.1
gene id: 6239:CELE_T05A10.1
uniprot id: Q7JM44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed at larval L1 and L3 stages and in adulthood.
messages: Expressed from larval stage L1 to adult stages but not during embryonic development.
messages: Expressed in the ventral nerve cord (VNC), pharynx, intestine and seam cells (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown causes a reduction in acetylcholine (ACh) content, altered sensitivity to Aldicarb, a potent acetylcholinesterase (AChE) inhibitor, reduced expression of vesicular acetylcholine transporter unc-17 and elevated levels of reactive oxygen species (PubMed:25407930). Knockdown inhibits nuclear localization of transcription factor daf-16 (PubMed:25407930).
messages: Transcription factor, probably acting as a transcriptional activator (PubMed:17397820). Required for patterning of male-specific genital sensilla (simple sense organs), known as rays (PubMed:20565799). Dispensable for regulation of body size (PubMed:20565799).
messages: Transcription factor, probably acting as a transcriptional activator and repressor, involved in the TGF-beta-like dbl-1 signaling pathway (PubMed:14627718, PubMed:17397820). Plays a role in regulation of body size, and patterning of male-specific genital sensilla (simple sense organs), known as rays, and mating-associated structures, spicules (PubMed:14627718). Required for the dorsoventral patterning of the postembryonic mesodermal lineage (M lineage), acting by antagonizing the TGF-beta-like dbl-1 signaling pathway, in part by repressing expression of transcription factor unc-130 (PubMed:16790477, PubMed:18036582, PubMed:29155044). Involved in egg-laying, perhaps via modulation of cholinergic neurotransmission (PubMed:25407930). May play a role in modulating lifespan and in responses to proteotoxic stress (PubMed:25407930).

6239:CELE Y71F9B.5
gene id: 6239:CELE_Y71F9B.5
uniprot id: A0A078BS14
uniprot id: G5EDV1
uniprot id: Q95Y45
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F40A3.3
gene id: 6239:CELE_F40A3.3
uniprot id: A0A0K3ASH2
uniprot id: O16264
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

6239:CELE F49E11.1
gene id: 6239:CELE_F49E11.1
uniprot id: A0A061ACK4
uniprot id: A0A061ACN7
uniprot id: A0A061AJ20
uniprot id: A0A061AKR6
uniprot id: Q9XTF3
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated during oocyte maturation by phosphorylation on Ser-362 by cdk-1. The pseudotyrosine phosphatases egg-4 and egg-5 sequester activated mbk-2 until the meiotic divisions and inhibit mbk-2 kinase activity directly, using a mixed-inhibition mechanism that does not involve tyrosine dephosphorylation.
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
messages: Expressed both maternally and zygotically.
messages: In L1 larvae, expressed widely in the nervous system, including head neurons and the ventral nerve cord. In adult animals, continues to be expressed in the nervous system and is also expressed in body wall muscle.
messages: Maternal-effect embryonic lethality due to defects in spindle positioning and cytokinesis in the early embryo (PubMed:12618396, PubMed:14697358). Microtubules are fragmented and disordered (PubMed:14697358). Abolishes phosphorylation of RNA-binding protein oma-1 in embryos (PubMed:16289132). RNAi-mediated knockdown causes an increase in taf-4 nuclear localization in the one-cell embryo (PubMed:18854162). RNAi-mediated knockdown causes a loss in plk-1 asymmetric localization in 2-cell stage embryo without affecting mex-5 polarization (PubMed:18199581). RNAi-mediated knockdown disrupts P granule distribution in zygotes after meiosis whereby zygotic P granules fail to disassemble in the anterior cytoplasm during zygote polarization, however new P granules assemble and accumulate in the posterior cytoplasm as in wild-type (PubMed:25535836).
messages: Part of a complex, consisting of pseudophosphatases egg-3, egg-4, egg-5 and kinase mbk-2; this complex is required for the oocyte-to-zygote transition (PubMed:19879842). Interacts (via Tyr-619 and Tyr-621) with egg-4 (via tyrosine-protein phosphatase domain) and egg-5 (via tyrosine-protein phosphatase domain); mbk-2 tyrosine phosphorylation enhances the interaction (PubMed:19879842). The interaction inhibits mbk-2 kinase activity and is required for mbk-2 oocyte cortex localization. Interacts (via N-terminus) with egg-3 (via tyrosine-protein phosphatase domain); the interaction does not affect mbk-2 kinase activity, is enhanced by mbk-2 tyrosine phosphorylation status and requires prior binding of mbk-2 to egg-4 and egg-5 (PubMed:17869113, PubMed:19879842).
messages: Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis (PubMed:16289132, PubMed:16338136, PubMed:17869113, PubMed:18854162, PubMed:18199581, PubMed:19879842). Through phosphorylation of P granule components including meg-1, promotes the disassembly of zygotic P granules in the anterior cytoplasm during zygote polarization, and thus plays a role in P granule distribution and segregation in early stage embryos following meiosis (PubMed:25535836). Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos (PubMed:14697358). Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage (PubMed:18199581).
messages: cell cortex

6239:CELE Y26E6A.3
gene id: 6239:CELE_Y26E6A.3
uniprot id: Q7YWR7
names: Similarity
messages: Belongs to the UPF0585 family.

6239:CELE F18E3.6
gene id: 6239:CELE_F18E3.6
uniprot id: Q19563
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y54G11A.7
gene id: 6239:CELE_Y54G11A.7
uniprot id: Q9XW01
names: Similarity
messages: Belongs to the TTC38 family.

6239:CELE Y95D11A.1
gene id: 6239:CELE_Y95D11A.1
uniprot id: Q9U1P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

6239:CELE Y43F4B.6
gene id: 6239:CELE_Y43F4B.6
uniprot id: O45935
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Chromosome
messages: Expressed in embryos.
messages: Expressed in the gonad.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryos that undergo early mitotic divisions as in wild-type, but which later then display aberrant patterns of nuclei and arrest before morphogenesis (PubMed:15452142). RNAi-mediated knockdown results in chromosome segregation defects in mitotic embryos whereby chromosomes form a disordered metaphase plate and multiple chromosomes exhibit delays in segregation resulting in the formation of bridges during anaphase (PubMed:15452142). The chromosome bridges stretch, break and sometimes form micronuclei (PubMed:15452142). RNAi-mediated knockdown results in kinetochore orientation defects in anaphase spindles in embryos in which kinetochores do not align on the spindle and some kinetochores stretch across the spindle interzone, parallel to the pole-pole axis (PubMed:15452142). RNAi-mediated knockdown does not cause defects in spindle architecture or cytokinesis in embryos (PubMed:15452142).
messages: Required for chromosome movement and orientation on spindle poles in mitosis and meiosis (PubMed:15452142). May play a role in early anterior-posterior chromosome movement in mitotic embryos (PubMed:15452142).
messages: nucleoplasm
messages: spindle

6239:CELE C27D6.6
gene id: 6239:CELE_C27D6.6
uniprot id: Q95ZY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed throughout the head.
messages: G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030).
messages: Perikaryon
messages: dendrite

6239:CELE Y17G7A.1
gene id: 6239:CELE_Y17G7A.1
uniprot id: G5EDQ2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus
messages: RNAi-mediated knockdown significantly reduces protein levels of ATP-dependent chaperones cdc-48.1 and cdc-48.2 in embryos.
messages: Transcriptional regulator (PubMed:18430416). Binds to specific sequence motifs in regulatory elements (PubMed:18430416). May recruit transcription factors, or may induce structural changes in chromatin, to thereby modulate embryonic expression of ATP-dependent chaperone cdc-48.1 (PubMed:18430416).

6239:CELE Y80D3A.5
gene id: 6239:CELE_Y80D3A.5
uniprot id: Q9U1R5
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE K01A2.2
gene id: 6239:CELE_K01A2.2
uniprot id: A0A0K3AWY0
uniprot id: H2KY95
uniprot id: Q9TZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE T25F10.6
gene id: 6239:CELE_T25F10.6
uniprot id: Q23050
names: Similarity
messages: Belongs to the calponin family.

6239:CELE T04F3.2
gene id: 6239:CELE_T04F3.2
uniprot id: Q22157
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y102A5A.1
gene id: 6239:CELE_Y102A5A.1
uniprot id: G5ED41
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAND family.
messages: In early embryos, expressed in all cells. Expression is higher during early stages and is reduced in late-stage embryos. Present in the one-cell stage zygote, indicating it is provided as a maternal product by the hermaphrodite parent. During larval stages, expressed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. Also observed in a subset of non-proliferative tissues, including hypodermal cells (at protein level).
messages: Interacts with cul-1, cul-2, cul-3, cul-4, cul-5 and cul-6.
messages: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
messages: Nucleus
messages: Worms show impenetrant phenotypes, including developmental arrest, morphological defects of the vulva and tail and reduced fecundity. Worms also display supernumerary seam cell divisions, defective alae formation, and the accumulation of the SCF(lin-23) target, the glutamate receptor glr-1. Increased levels of the neddylated isoforms of Cul-2 and cul-4.

6239:CELE F48E8.5
gene id: 6239:CELE_F48E8.5
uniprot id: Q09543
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1 (PubMed:23336080, PubMed:17218259). During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation (PubMed:10521400). Plays a positive role in axon guidance probably by inhibiting phosphatase let-92 (PubMed:20392746).
messages: Belongs to the phosphatase 2A regulatory subunit A family.
messages: Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
messages: Part of a complex consisting of a common heterodimeric core enzyme, composed of catalytic subunit let-92 and constant regulatory subunit paa-1, that associates with a variety of regulatory subunits which confer distinct properties to the holoenzyme (PubMed:17218259, PubMed:21497766). Interacts with rsa-1 (PubMed:17218259).
messages: RNAi-mediated knockdown causes severe embryonic lethality (PubMed:10521400, PubMed:23336080). Causes a failure to duplicate centrioles resulting in the formation of monopolar spindles at the 2-cell embryonic stage (PubMed:21497766, PubMed:23336080). sas-5 protein levels are reduced in embryos (PubMed:21497766). The few surviving animals lack a vulva resulting from defects in vulva cell induction, vulva precursor cell (VPC) generation and in vulval execution linage (PubMed:10521400). Partially suppresses multivulva formation in a let-60 n1046 mutant background (PubMed:10521400).
messages: centrosome
messages: spindle

6239:CELE C29E4.4
gene id: 6239:CELE_C29E4.4
uniprot id: P34343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: Important for early nematode development.
messages: Nucleus envelope
messages: nuclear pore complex

6239:CELE D1014.5
gene id: 6239:CELE_D1014.5
uniprot id: Q18918
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE ZC334.11
gene id: 6239:CELE_ZC334.11
uniprot id: Q7JKM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE Y45G5AL.2
gene id: 6239:CELE_Y45G5AL.2
uniprot id: A0A168H3E7
uniprot id: Q4R170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C02F5.13
gene id: 6239:CELE_C02F5.13
uniprot id: P61228
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM2 family.
messages: Membrane

6239:CELE W01B11.3
gene id: 6239:CELE_W01B11.3
uniprot id: O45012
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

6239:CELE F10D2.8
gene id: 6239:CELE_F10D2.8
uniprot id: A0A131MBU2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K09B11.1
gene id: 6239:CELE_K09B11.1
uniprot id: G5ECP4
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Expressed in the nervous system.
messages: Interacts with actl-1.
messages: Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input.

6239:CELE R102.4
gene id: 6239:CELE_R102.4
uniprot id: C6KRK8
uniprot id: C6KRK9
uniprot id: Q21890
names: Similarity
messages: Belongs to the threonine aldolase family.

6239:CELE F56D5.1
gene id: 6239:CELE_F56D5.1
uniprot id: Q20880
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T23D8.4
gene id: 6239:CELE_T23D8.4
uniprot id: O02328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE Y49E10.3
gene id: 6239:CELE_Y49E10.3
uniprot id: Q9XTT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.
messages: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

6239:CELE F28D1.9
gene id: 6239:CELE_F28D1.9
uniprot id: Q19878
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE Y39B6A.22
gene id: 6239:CELE_Y39B6A.22
uniprot id: Q8MYN7
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE F07H5.2
gene id: 6239:CELE_F07H5.2
uniprot id: Q19185
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

6239:CELE Y54F10AM.2
gene id: 6239:CELE_Y54F10AM.2
uniprot id: Q9BKZ9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Embryonic lethality or larval arrest (PubMed:11896189, PubMed:15355315). Heterozygous animals are viable and display increased pharyngeal pumping rates associated with reduced acetylcholinesterase activity (PubMed:11896189, PubMed:15355315).
messages: Expressed in the pharynx (including pharyngeal muscle and nerve cells), ventral nerve cord and tail neurons.
messages: Expressed in the pharynx from three-fold stage embryos to adulthood.
messages: Interacts (via PID 2 domain) with apl-1 (via cytoplasmic domain).
messages: Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2 (PubMed:11896189, PubMed:15355315).
messages: Phosphorylated.
messages: cytoskeleton

6239:CELE Y59E9AR.5
gene id: 6239:CELE_Y59E9AR.5
uniprot id: Q9N2K7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Alters embryonic vab-7 expression pattern.
messages: Involved in the regulatory network to control embryonic patterning and morphogenesis. Implicated in negatively regulating vab-7 expression at the anterior of embryos.
messages: Nucleus

6239:CELE Y106G6H.15
gene id: 6239:CELE_Y106G6H.15
uniprot id: Q9XWS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SKA1 family.
messages: Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (By similarity). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:23085020).
messages: Component of the ska-1 complex, composed of two copies of ska-1 and a single copy of ska-3. The core complex associates with microtubules and may form dimeric assemblies. Interacts with ska-3 and microtubules.
messages: kinetochore
messages: spindle

6239:CELE T28F3.6
gene id: 6239:CELE_T28F3.6
uniprot id: Q9XUC2
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Ciliated sensory neurons.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Regulates specific signaling activities in the cilia, such as the daf-2/insulin receptor-like transduction pathway (PubMed:16968739).
messages: In contrast to other members of the family, does not contain a prenylation domain.
messages: Worms have an extended lifespan phenotype and are defective in dauer formation.
messages: cilium axoneme

6239:CELE F57C12.4
gene id: 6239:CELE_F57C12.4
uniprot id: Q20943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE F45E12.1
gene id: 6239:CELE_F45E12.1
uniprot id: Q20432
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dullard family.
messages: Excess of internal nuclear membranes in oocyte-derived pronuclei that are nearly or completely bisecting the nucleus in embryos during nuclear closure (PubMed:32271860). Increased phosphatidylinositol (PI) production and ectopic ER sheets (PubMed:32271860). Nuclei contain openings through which imported proteins passively diffuse (PubMed:32271860). Twinned nuclei after mitosis (PubMed:32271860). Simultaneous knockdown of chmp-7 or lem-2 leads to enhanced nuclear sealing defects (PubMed:32271860).
messages: Membrane
messages: Nucleus envelope
messages: Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases (PubMed:22134922). Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (PubMed:22134922). May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics (PubMed:22134922). Contributes to closure of nuclear envelope (NE) holes and prevents excess nuclear membranes after meiosis and mitosis, possibly through spatial regulation of lipin (PubMed:32271860). May limit the production of endoplasmic reticulum (ER) sheets proximal to the NE to prevent the ER membranes that feed into NE openings from invading the nuclear interior and thereby restrict nuclear transport to nuclear pore complexes (NPCs) (PubMed:32271860). May also indirectly regulate the production of lipid droplets and triacylglycerol (PubMed:22134922).

6239:CELE C13B9.2
gene id: 6239:CELE_C13B9.2
uniprot id: Q09235
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

6239:CELE F41G4.2
gene id: 6239:CELE_F41G4.2
uniprot id: H2L023
names: Similarity
messages: Belongs to the CAP family.

6239:CELE F42A9.7
gene id: 6239:CELE_F42A9.7
uniprot id: Q95ZT8
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T24C4.5
gene id: 6239:CELE_T24C4.5
uniprot id: Q9TZ34
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

6239:CELE F41D3.3
gene id: 6239:CELE_F41D3.3
uniprot id: O45507
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y116A8C.18
gene id: 6239:CELE_Y116A8C.18
uniprot id: Q9U2V3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y47H10A.5
gene id: 6239:CELE_Y47H10A.5
uniprot id: Q9U2B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE Y71G10AR.4
gene id: 6239:CELE_Y71G10AR.4
uniprot id: Q33BL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

6239:CELE T11A5.6
gene id: 6239:CELE_T11A5.6
uniprot id: G5EEZ6
names: Similarity
messages: Belongs to the peptidase C2 family.

6239:CELE C25E10.9
gene id: 6239:CELE_C25E10.9
uniprot id: Q18158
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In male, expressed in the vas deferens cuboidal cells and, in posterior body wall and male-specific diagonal muscles (PubMed:30470702). In hermaphrodites, expressed in posterior body wall muscles and spermatheca (PubMed:30470702).
messages: In males, expression begins at late larval stage and continues in adults.
messages: Secreted
messages: Serine protease inhibitor (Probable) (PubMed:22125495). Probably by inhibiting serine protease tyr-5 in males, prevents the maturation of spermatids into mature motile spermatozoa until their transfer into a hermaphrodite (PubMed:16461278, PubMed:22125495, PubMed:30470702). Also required for efficient sperm transfer and thus for male fertility (PubMed:16461278).
messages: secretory vesicle lumen

6239:CELE B0261.2
gene id: 6239:CELE_B0261.2
uniprot id: Q95Q95
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family.
messages: Defects strongly increase lifespan, the mean lifetime being of 25 days instead of 10 days, suggesting that it may be involved in aging process (PubMed:14668850). RNAi-mediated knockdown results in increased longevity and a reduced nucleoli size (PubMed:28853436). RNAi-mediated knockdown in a ncl-1 mutant background (e1942) reduces the increased longevity and suppresses the reduced nucleoli size of the let-363 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436). RNAi-mediated knockdown in the germline causes sterility, a severe reduction in the number of germline progenitors and a delay in G2 phase of the cell cycle (PubMed:22278922). RNAi-mediated knockdown results in no sepa-1 containing aggregates at the comma stage of embryonic development indicative of no germ cell specific P-granules at this stage (PubMed:19377305). RNAi-mediated knockdown enhances the loss of touch receptor neurons in a mec-4 u231 mutant (PubMed:17327275).
messages: Nucleus
messages: Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2 (PubMed:12225660). It may have some protein kinase activity instead of lipid kinase activity (PubMed:12225660). May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis (PubMed:19377305). Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1 (PubMed:22278922). Required for larval development (PubMed:22278922). May act as a mediator of lifespan regulation by insulin signaling and nutrient sensing (PubMed:14668850, PubMed:28853436).
messages: Ubiquitous. Expressed in all major tissues and organs, including the intestine, gonads and hypodermal cells (PubMed:12225660). Expressed in neurons (PubMed:17327275).

6239:CELE B0250.1
gene id: 6239:CELE_B0250.1
uniprot id: Q9XVF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Cytoplasm

6239:CELE C05C10.3
gene id: 6239:CELE_C05C10.3
uniprot id: Q09450
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Homodimer.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
messages: Mitochondrion

6239:CELE F54D7.6
gene id: 6239:CELE_F54D7.6
uniprot id: A0A0M6VD87
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.

6239:CELE Y6E2A.9
gene id: 6239:CELE_Y6E2A.9
uniprot id: O45976
uniprot id: Q7K7S6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE ZK520.3
gene id: 6239:CELE_ZK520.3
uniprot id: G5ECZ4
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the IFT complex A (IFT-A) composed of at least che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
messages: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:28479320). Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme (PubMed:16957054, PubMed:22922713). May also associate with the BBSome complex in order to mediate ciliary transport (PubMed:22922713). Regulates cilia biogenesis, morphology and sensitivity to environmental cues (PubMed:16957054, PubMed:22922713).
messages: Defects in cilium morphology and mislocalization of intraflagellar transport proteins. Specifically, phasmid cilia are shorter compared to wild-type, ciliary IFT A complex proteins such as che-11, osm-5 are mislocalized, and the transport and accumulation of the ciliary IFT B complex protein che-13 is impaired. Mutants also display a strong osmosensory (osm) phenotype with an aversion to high osmolarity, and they exhibit impaired chemotaxis in response to volatile odorants such as pyrazine and iso-amyl alcohol.
messages: Expressed in ciliated sensory neurons.
messages: cilium

6239:CELE Y38F2AR.12
gene id: 6239:CELE_Y38F2AR.12
uniprot id: A0A9S2
names: Similarity
messages: Belongs to the oxoprolinase family.

6239:CELE H31G24.4
gene id: 6239:CELE_H31G24.4
uniprot id: Q9BLB5
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE F15A2.2
gene id: 6239:CELE_F15A2.2
uniprot id: G5EDP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

6239:CELE C50F4.14
gene id: 6239:CELE_C50F4.14
uniprot id: Q968A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Golgi apparatus membrane
messages: Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.

6239:CELE Y46H3C.3
gene id: 6239:CELE_Y46H3C.3
uniprot id: Q9N4W0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y39B6A.24
gene id: 6239:CELE_Y39B6A.24
uniprot id: Q8MYN5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aspartic proteinase.
messages: Belongs to the peptidase A1 family.
messages: Expressed in intestinal cells.
messages: Induced in response to thermal stress in conditions where severe cold temperatures are followed by warmer temperatures (PubMed:29664006). In particular, induced in the warming phase (10 to 22 degrees Celsius) during the cold (4 degrees Celsius) to warm (22 degrees Celsius) temperature transition (PubMed:29664006).
messages: Secreted

6239:CELE ZK328.2
gene id: 6239:CELE_ZK328.2
uniprot id: Q23463
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

6239:CELE F09B12.2
gene id: 6239:CELE_F09B12.2
uniprot id: O62144
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE B0454.7
gene id: 6239:CELE_B0454.7
uniprot id: O17166
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F46F11.4
gene id: 6239:CELE_F46F11.4
uniprot id: P91302
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Expression increased by citrate dietary supplementation.
messages: Interacts with dve-1; the interaction occurs in a mitochondrial stress-dependent manner.
messages: Involved in the mitochondrial unfolded protein response (mtUPR) (PubMed:17925224). Plays a role in modulation of lipid metabolism in response to the citrate-induced mtUPR, acting upstream of transcription factor nhr-80 (PubMed:35021096).
messages: RNAi-mediated knockdown inhibits expression of hsp-60 when adults are exposed to conditions causing mitochondrial unfolded protein stress.

6239:CELE ZC518.2
gene id: 6239:CELE_ZC518.2
uniprot id: Q23368
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R03D7.7
gene id: 6239:CELE_R03D7.7
uniprot id: Q09597
names: Similarity
messages: Belongs to the nanos family.

6239:CELE C08F11.8
gene id: 6239:CELE_C08F11.8
uniprot id: Q9U3Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y116A8B.5
gene id: 6239:CELE_Y116A8B.5
uniprot id: O62403
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE Y105C5A.23
gene id: 6239:CELE_Y105C5A.23
uniprot id: Q9U320
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in the ASI and ASK chemosensory neurons and in the IL-2 interneurons, but weakly expressed in other head neurons in hermaphrodites.
messages: G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5.
messages: Heterodimer; with daf-37.

6239:CELE W01G7.4
gene id: 6239:CELE_W01G7.4
uniprot id: Q9XVH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

6239:CELE R07B7.15
gene id: 6239:CELE_R07B7.15
uniprot id: Q21805
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE T05A6.6
gene id: 6239:CELE_T05A6.6
uniprot id: H2L274
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F49E8.5
gene id: 6239:CELE_F49E8.5
uniprot id: Q27257
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Although dif-1 activity is required only during embryogenesis, it is expressed at all stages of development.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.

6239:CELE F48B9.5
gene id: 6239:CELE_F48B9.5
uniprot id: Q20551
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K04G2.9
gene id: 6239:CELE_K04G2.9
uniprot id: Q21228
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F53C11.3
gene id: 6239:CELE_F53C11.3
uniprot id: Q93761
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

6239:CELE Y71H10A.1
gene id: 6239:CELE_Y71H10A.1
uniprot id: Q9TZL8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

6239:CELE F58E10.5
gene id: 6239:CELE_F58E10.5
uniprot id: Q9XUW7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y57A10A.25
gene id: 6239:CELE_Y57A10A.25
uniprot id: Q9NA76
names: Similarity
messages: Belongs to the CAF1 family.

6239:CELE T19B10.8
gene id: 6239:CELE_T19B10.8
uniprot id: Q22561
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Membrane

6239:CELE R10H10.1
gene id: 6239:CELE_R10H10.1
uniprot id: Q21915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion
messages: Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.

6239:CELE T06A4.1
gene id: 6239:CELE_T06A4.1
uniprot id: H2L0K5
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE Y56A3A.11
gene id: 6239:CELE_Y56A3A.11
uniprot id: Q9U218
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.

6239:CELE ZK54.1
gene id: 6239:CELE_ZK54.1
uniprot id: Q23514
uniprot id: Q2PJ91
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T04F8.1
gene id: 6239:CELE_T04F8.1
uniprot id: Q22161
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE Y45F3A.3
gene id: 6239:CELE_Y45F3A.3
uniprot id: Q9XWZ2
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: By heat. Two-fold induction at 25 degrees Celsius compared with 15 degrees Celsius.
messages: Homotetramer; dimer of dimers.
messages: Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat.
messages: Temperature-sensitive mutants in which embryos develop to adulthood at 15 and 20 degrees Celsius, but have a poor survival incidence at 25 degrees Celsius. Mutants have increased membrane fluidity and abnormal compositions of fatty acid species.

6239:CELE K07C11.2
gene id: 6239:CELE_K07C11.2
uniprot id: G5EDL3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

6239:CELE F48E8.1
gene id: 6239:CELE_F48E8.1
uniprot id: Q09566
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the CRISP family.
messages: Expressed in hypodermal tissues.
messages: Regulates body size morphogenesis, but does not affect male tail development.

6239:CELE F26F4.1
gene id: 6239:CELE_F26F4.1
uniprot id: Q19824
names: Similarity
messages: Belongs to the GET4 family.

6239:CELE C29E4.7
gene id: 6239:CELE_C29E4.7
uniprot id: P34345
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the GST superfamily. Omega family.
messages: Cytoplasm
messages: Exhibits glutathione-dependent thiol transferase activity (By similarity). Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid (By similarity). Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity). Protects against environmental stress and oxidative stress (PubMed:17901115).
messages: Expressed in late embryos, during the L1 to L4 stages of larval development and in adult hermaphrodites.
messages: Expressed in the intestinal cells.
messages: Homodimer.
messages: RNAi-mediated knockdown results in increased sensitivity and reduced survival in response to oxidative stress inducers cumene hydroperoxide, jugalone, paraquat and arsenite, and to heat shock treatment.

6239:CELE ZK1251.2
gene id: 6239:CELE_ZK1251.2
uniprot id: H9G2S9
uniprot id: Q23430
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Insulin-like peptide which plays a role in ageing as a consequence of daf-16 activity.
messages: RNAi-mediated knockdown extends lifespan.
messages: Secreted

6239:CELE C35D10.5
gene id: 6239:CELE_C35D10.5
uniprot id: Q18485
names: Similarity
messages: Belongs to the CBP3 family.

6239:CELE T02E9.1
gene id: 6239:CELE_T02E9.1
uniprot id: O18014
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE R06A4.7
gene id: 6239:CELE_R06A4.7
uniprot id: O17514
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
messages: Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed, while it is expressed at intermediate levels in the germline of L4 larvae.
messages: In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells (PubMed:9609829, PubMed:29702639). Expressed in the hypoderm (PubMed:29702639).
messages: Interacts directly with mes-6 via its N-terminal domain (PubMed:11320248). Forms a heterotrimeric complex with mes-3 and mes-6 (PubMed:11320248, PubMed:15380065). Does not interact with mes-4 (PubMed:11320248).
messages: Nucleus
messages: Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head (PubMed:17574230). PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259). Involved in the negative regulation of lifespan in a germline-independent fashion (PubMed:22212395).
messages: RNAi-mediated knockdown results in extended lifespan in wild type worms and in a glp-1(e2141) mutant background which lacks a germline (PubMed:22212395). Also leads to reduced H3K27me3 levels on metaphase chromosomes (PubMed:26904949). Double RNAi-mediated knockdown together with mes-6 RNAi results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). This ectopic expression of egl-5 in the head region is enhanced in a nfya-1 bp4 mutant background (PubMed:17574230). In addition in this background in males, there is ectopic expression of egl-5 in the mid-body region including in seam cells and hypodermal nuclei, and there is ectopic ray formation (PubMed:17574230).

6239:CELE C36E8.1
gene id: 6239:CELE_C36E8.1
uniprot id: P48322
names: Similarity
messages: Belongs to the RRN3 family.

6239:CELE Y75B8A.4
gene id: 6239:CELE_Y75B8A.4
uniprot id: Q9XW87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

6239:CELE T10H4.8
gene id: 6239:CELE_T10H4.8
uniprot id: O45778
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T02E9.3
gene id: 6239:CELE_T02E9.3
uniprot id: O45732
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE K04F10.1
gene id: 6239:CELE_K04F10.1
uniprot id: O44771
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F30B5.7
gene id: 6239:CELE_F30B5.7
uniprot id: Q19913
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F13H10.8
gene id: 6239:CELE_F13H10.8
uniprot id: Q1ZXU7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F56F3.6
gene id: 6239:CELE_F56F3.6
uniprot id: G5EFH1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 33% reduction in the larval diapause in the presence of dauer pheromone compared to wild-type.
messages: Belongs to the insulin family.
messages: Expressed during larval and adult stages with the highest expression during the L2 stage of larval development (PubMed:14730154). Expressed in head neurons at pre-dauer, dauer and post-dauer larval stages (PubMed:23132577). During the dauer stage, also expressed in tail neurons, amphid neurons, the ventral nerve cord and AVG interneurons (PubMed:23132577).
messages: Expressed in head neurons and the uterus.
messages: Involved in the regulation of the larval diapause.
messages: Secreted

6239:CELE Y10G11A.1
gene id: 6239:CELE_Y10G11A.1
uniprot id: E4MYG2
uniprot id: Q95ZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

6239:CELE F36A4.10
gene id: 6239:CELE_F36A4.10
uniprot id: P34687
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE K10D2.1
gene id: 6239:CELE_K10D2.1
uniprot id: Q09589
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

6239:CELE K02E10.8
gene id: 6239:CELE_K02E10.8
uniprot id: B1Q236
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are viable, fertile and coordinated (PubMed:12628183). Defective HSN axon branching at the vulva (PubMed:12628183). Abnormal synaptic vesicle clustering in HSNL motor neuron (PubMed:12628183, PubMed:15035988). Synapses in the secondary synapse region, anterior to the vulva, are not eliminated during synapse development and persist into adulthood (PubMed:17626846).
messages: Belongs to the immunoglobulin superfamily.
messages: Cell adhesion protein (PubMed:15035988). Involved in synapse formation in the HSNL egg-laying motor neuron (PubMed:12628183, PubMed:15035988, PubMed:21858180, PubMed:24485456). Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination (PubMed:17626846). Also required for F-actin assembly at the synaptic region and for axon branch formation (PubMed:24439377).
messages: Cell membrane
messages: Expression in head motor neurons, occasionally in HSN neurons and weakly in other cells in the vulval region (PubMed:12628183). Expressed in the primary synapse region of HSNL motor neuron (PubMed:18675916, PubMed:21858180).
messages: Interacts with skr-1 (PubMed:17626846). Interacts with syg-2 (PubMed:21858180, PubMed:24485456). Interacts with the WAVE regulatory complex; the interaction leads to formation of a synaptic F-actin network that is required for synapse formation and axon branching (PubMed:24439377).
messages: Localized to the primary synapse region in the vulva from early larval stage L4 to young adult stage.
messages: Synapse
messages: The first Ig-like domain is necessary for localization to the primary synapse region of HSNL motor neurons.
messages: axon

6239:CELE Y17D7A.3
gene id: 6239:CELE_Y17D7A.3
uniprot id: O45907
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T14F9.4
gene id: 6239:CELE_T14F9.4
uniprot id: A0A5S9MMK5
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed widely throughout development (at protein level) (PubMed:11203704). Earliest expression at the embryonic comma stage; expressed in the developing pharynx, hypodermal cells, hindgut lining, and also in several cells near the rectum and in the tail (at protein level) (PubMed:11203704, PubMed:15581870). Expressed in pharynx until adulthood, when it becomes undetectable (at protein level) (PubMed:11203704). Expression in adult hermaphrodites may be highest in the germ line (PubMed:11203704).
messages: May not bind metals in vitro (PubMed:15165844). It is possible that some phenotypes due to mutant cu9 allele are due to deletion of predicted flanking non-coding RNA genes.
messages: Nucleus
messages: Putative transcription factor (PubMed:11203704). Binds to specific sequence motif 5'-[TC][AGT]TGCC[GA][AT]-3' in regulatory elements of target genes such as myosin myo-2 (PubMed:11203704, PubMed:15165844). May modulate gene expression, perhaps acting in opposition to transcription factor pha-4 (PubMed:11203704, PubMed:12095247). Involved in morphogenesis, perhaps especially in formation of the pharynx (PubMed:11203704, PubMed:15581870). Plays roles in molting, feeding and morphology (PubMed:15581870).
messages: RNAi-mediated knockdown causes multiple defects, including embryonic lethality, slow larval growth, abnormal tail morphology, constipation, abnormal vulva, and abnormal pharynx.

6239:CELE F59E10.1
gene id: 6239:CELE_F59E10.1
uniprot id: Q21037
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
messages: Nucleus
messages: ORC is composed of six subunits.

6239:CELE T26E3.3
gene id: 6239:CELE_T26E3.3
uniprot id: Q9NAN2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Colocalized with par-3 at all stages in early embryos, at the anterior cortex of the embryo. Patchy expression observed at the periphery after completion of meiosis I and in meiosis II, which on completion of metaphase II, is restricted to the anterior 85% of embryo length; this decreases to 55% in embryos between prophase and telophase of the first mitosis. During the first cleavage, expression is detected in the advancing furrow. Along with pkc-3, is unable to associate with the apical cortex of cells that lack par-3. Transiently coexpressed and colocalized with par-3 and pkc-3, asymmetrically in the developing somatic gonad, including the spermathecal precursor cells of L4 larvae.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Interacts with par-3, required for its peripheral localization, and with cdc-42, required for the activation of a par-3/par-6/pkc-3 complex.
messages: Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis (PubMed:8898226). Required for localizing/ maintaining par-3 at the cell periphery (PubMed:9834192, PubMed:8898226). Regulates mes-1 expression and/or localization pattern during early embryogenesis (PubMed:11003841). Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca (PubMed:13129846, PubMed:15151982). Plays a role in endosome and Golgi body positioning (PubMed:22634595).
messages: RNAi-mediated knockdown results in a diffuse distribution of early, recycling and late endosomes and Golgi bodies and reduced intensities of markers for these organelles.
messages: tight junction

6239:CELE F57B9.5
gene id: 6239:CELE_F57B9.5
uniprot id: Q20932
names: Similarity
messages: Belongs to the bystin family.

6239:CELE T09E11.6
gene id: 6239:CELE_T09E11.6
uniprot id: O02312
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE Y73B6BL.7
gene id: 6239:CELE_Y73B6BL.7
uniprot id: Q9TZP5
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Although the active site residues Cys and His are conserved, appears to lack catalytic activity in vitro. This is probably due to the active site pentapeptide VCCRG being highly divergent from the canonical active site pentapeptide QAC[RQG]G present in catalytically active caspases.
messages: Belongs to the peptidase C14A family.
messages: Cleavage by csp-1 isoform b or ced-3 removes the propeptide and generates subunit p31 in vitro. An additional cleavage at Asp-149 generates the 2 subunits p17 and p14 but this cleavage appears to be less efficient.
messages: Cytoplasm
messages: Interacts with ced-3 (via large subunit p17 or small subunit p13); the interaction inhibits ced-3 autoactivation.
messages: Putative inactive caspase (PubMed:9857046). Dispensable for the inhibition of germline apoptosis (PubMed:19575016).
messages: Putative inactive caspase (PubMed:9857046). In the germline, binds caspase ced-3 zymogen and prevents ced-3 autoactivation. Does not affect the caspase activity of mature ced-3 and ced-4-mediated mature ced-3 activation (PubMed:19575016). Negatively regulates germline apoptosis by inhibiting autocleavage of caspase ced-3 (PubMed:19575016). Involved in fertility (PubMed:19575016).
messages: Specifically expressed in the hermaphrodite germline.
messages: Survival of touch neurons and several pharyngeal cells is not affected during development. In a ced-3 n2427 or ced-3 n2427 and cps-3 n4872 mutant background, no extra pharyngeal cells caused by impaired apoptosis are produced. In a csp-3 n4872, csp-1 n4967 and ced-3 n3692 mutant background, pharyngeal cells, that are normally fated to die, survive and 16 percent of animals have still 1 or more cell corpses that are morphologically apoptotic and are internalized by engulfing cells. In addition, apoptosis of the male linker cell occurs normally.

6239:CELE Y47G6A.7
gene id: 6239:CELE_Y47G6A.7
uniprot id: Q6AW10
uniprot id: Q9N3S9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F08B12.1
gene id: 6239:CELE_F08B12.1
uniprot id: Q19188
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane

6239:CELE Y6B3B.11
gene id: 6239:CELE_Y6B3B.11
uniprot id: Q9XWF0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although thought to contribute to D(4)-dafrachronic acid biosynthesis, the latter may not be present at physiologically relevant concentrations in C.elegans and comparative metabolomics would indicate 7-dehydrogenase activity and participation in D(7)-dafrachronic acid biosynthesis instead.
messages: Belongs to the 3-beta-HSD family.
messages: Expressed exclusively in the neuron-like XXX(L/R) cells through all four larval stages and becomes fainter in adults.
messages: Hydroxysteroid dehydrogenase involved in the biosynthesis of dafrachonic acids (PubMed:18495818, PubMed:20178781, PubMed:24411940). Catalyzes the dehydrogenation of cholesterol or its derivatives and the isomerization of the double carbon bond on the sterol ring. Modifies sterols into a Delta(4)-3-keto-sterols such as cholest-4-en-3-one, precursor of Delta(4)-dafachronic acid (PubMed:18495818). Contributes to the production of Delta(7)-dafachronic acid in the XXX cells (PubMed:24411940). Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12 suppressing dauer formation and inducing reproductive growth (PubMed:18495818, PubMed:24411940). Acts in parallel to AKT-1 to promote reproductive development via DAF-16/FoxO and DAF-12 (PubMed:20178781).
messages: Membrane
messages: Mutants are hypersensitive to pheromone induction and form dauers more readily than the wild-type.

6239:CELE F26D2.3
gene id: 6239:CELE_F26D2.3
uniprot id: Q9U3H9
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE B0035.12
gene id: 6239:CELE_B0035.12
uniprot id: Q17430
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in embryos, larvae and adults.
messages: Forms a complex composed of sart-3, terminal uridylyltransferase usip-1 and U6 snRNA; complex formation is mediated by usip-1 and sart-3 binding to U6 snRNA (PubMed:25753661). Associates with U4 and U6 snRNP complexes, probably by interacting with U4 and U6 snRNAs (PubMed:25753661).
messages: Lethal at the young adult stage due to a ruptured vulva (PubMed:25753661). RNAi-mediated knockdown causes a partial reduction in the number of hatched embryos (PubMed:25753661). RNAi-mediated knockdown in a usip-1 (tm1897) mutant background causes complete embryonic lethality (PubMed:25753661).
messages: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery (PubMed:25753661). Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:25753661).
messages: Ubiquitously expressed.
messages: nucleoplasm

6239:CELE T22C1.2
gene id: 6239:CELE_T22C1.2
uniprot id: Q22663
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Binds carbon monoxide (CO).
messages: Cell membrane
messages: Cytoplasm
messages: Detected in the head mesodermal cell. In the tail region, detected in the stomatointestinal and anal depressor muscle cells.
messages: Expressed at all developmental stages, but expression relative to adult is decreased in the L3 and dauer stages.
messages: Homodimer. Occurs in an equilibrium of monomeric and dimeric forms in solution.
messages: Nucleus lamina
messages: Plays a role in electron transport. Utilizes the bis-histidyl hexacoordinated complex with iron to transfer electrons to cytochrome c and molecular oxygen. Plays a regulatory role in the periodicity of the defecation cycle under oxidative stress conditions. Not involved in imparting protection against general conditions of oxidative stress. May participate in redox reactions under anaerobic conditions.
messages: Up-regulated by anoxia but not affected by hypoxia.

6239:CELE Y38F2AL.3
gene id: 6239:CELE_Y38F2AL.3
uniprot id: Q9XXU9
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase C subunit family.
messages: Cytoplasm
messages: Expressed ubiquitously; higher levels are found in gastrointestinal and hypodermal cells, as well as H-shaped excretory cell.
messages: Membrane
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (Probable). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). Has roles in embryogenesis and ovulation (PubMed:10846178).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunits a1 unc-32, a2 vha-5 and a3 vha-6 (PubMed:11441002).
messages: Vha-11 and vha-3 are transcribed on a dicistronic transcript where vha-3 is the upstream transcript and vha-11 the downstream.
messages: Worms display embryonic lethality. When vha-11 is silenced in adults, they are able to produce eggs but egg numbers gradually decrease and worms become sterile after 24 hours. This sterility continues for about 4 days and then viable eggs are produced again.

6239:CELE Y71F9AL.13
gene id: 6239:CELE_Y71F9AL.13
uniprot id: Q9N4I4
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

6239:CELE ZK863.4
gene id: 6239:CELE_ZK863.4
uniprot id: Q23652
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a specific terminal uridylyltransferase for U6 snRNA. Responsible for the addition of UTP at the 3' end of U6 snRNA which stabilizes U6 snRNA (PubMed:25753661). Does not have activity towards modified uridine containing 3'-monophosphorylation or 2'-O-methylation (PubMed:25753661).
messages: Belongs to the DNA polymerase type-B-like family.
messages: Binds 1 divalent cation per subunit.
messages: Forms a complex composed of sart-3, terminal uridylyltransferase usip-1 and U6 snRNA; complex formation is mediated by usip-1 and sart-3 binding to U6 snRNA.
messages: Ubiquitously expressed.
messages: nucleoplasm

6239:CELE F49E10.3
gene id: 6239:CELE_F49E10.3
uniprot id: G5EEC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor in vitro.
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Expressed in eggs, all larval stages and in adult (PubMed:9685599). Expressed in the ALA neuron in L4 stage larvae (PubMed:27546573).
messages: Expressed in the ASI sensory neurons, the ALA interneuron and the AVG interneuron from where secretion occurs. Expression in the ASI neurons is necessary and sufficient to maintain serotonin-induced fat loss.
messages: FMRFamide-like neuropeptides (PubMed:16377032, PubMed:28128367). Stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss (PubMed:33078707). Together with atfs-1, negatively regulates the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress (PubMed:33078707).
messages: Retention of a significantly greater proportion of body fat compared to wild-type following treatment with serotonin, almost complete suppression of the transcriptional induction of the atgl-1 lipase, reduced egg-laying and suppression of octopamine-induced fat loss. No effect on serotonin-induced food intake, reproduction or the enhanced slowing response which is a satiety-like locomotor response to food availability.
messages: SPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro.
messages: Secreted
messages: TPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro.

6239:CELE Y80D3A.1
gene id: 6239:CELE_Y80D3A.1
uniprot id: G5EDY2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE K12B6.1
gene id: 6239:CELE_K12B6.1
uniprot id: A0A0T7CIX3
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE F42C5.9
gene id: 6239:CELE_F42C5.9
uniprot id: Q20329
names: Similarity
messages: Belongs to the actin family.

6239:CELE D2013.9
gene id: 6239:CELE_D2013.9
uniprot id: Q09512
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Although it belongs to the tubulin--tyrosine ligase family, the TTL domain lacks some of the ATP binding sites predicted to be essential for TTL activity (By similarity). Lacks tyrosine ligase activity in vitro (By similarity). Lacks glutamylation activity in vitro (By similarity).
messages: Belongs to the tubulin--tyrosine ligase family.
messages: RNAi-mediated knockdown at the L1 larval stage causes a reduction in egg-laying, likely due to a defect in the egg-laying apparatus muscles and in hermaphrodite specific neurons.
messages: Regulates microtubule dynamics in uterine muscle cells.

6239:CELE M01H9.2
gene id: 6239:CELE_M01H9.2
uniprot id: Q95018
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE H06H21.6
gene id: 6239:CELE_H06H21.6
uniprot id: Q8WTJ4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subunit
names: Tissue Specificity
messages: Expressed at L4 larval stage and in adults. Expressed at low levels in embryos and between the L1 and L3 larval stages.
messages: Expressed in the pharynx and some head neurons.
messages: Interacts with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus).
messages: Probably acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions (PubMed:30595383).
messages: Reduced lifespan (PubMed:30595383). Prolonged expression of the lysosomal protein glo-1 12 hours after starvation (PubMed:30595383).
messages: Up-regulated in response to starvation (at protein level).

6239:CELE C40A11.3
gene id: 6239:CELE_C40A11.3
uniprot id: Q9TZA9
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE T12A7.1
gene id: 6239:CELE_T12A7.1
uniprot id: Q22422
names: Similarity
messages: Belongs to the copine family.

6239:CELE R02D5.8
gene id: 6239:CELE_R02D5.8
uniprot id: A8WHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion

6239:CELE ZC504.4
gene id: 6239:CELE_ZC504.4
uniprot id: Q23356
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Involved in cell migration and signal transduction (PubMed:11967148, PubMed:22732572). Important in several developmental processes including epidermal development, Q neuroblast migrations and muscle arm targeting. Required with ina-1/pat-3 to stabilize the commissural axons growth cone along a precise direction and are required for the cell to respond appropriately when signaling in the growth cone must change (PubMed:11967148). During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms (PubMed:22732572).
messages: Mutants exhibit premature branching of commissures (PubMed:11967148). RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis (PubMed:22732572). Double knockdown with mig-38 results in enhanced gonad DTC migration defects (PubMed:22732572).

6239:CELE ZK1248.2
gene id: 6239:CELE_ZK1248.2
uniprot id: Q23422
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F38A6.1
gene id: 6239:CELE_F38A6.1
uniprot id: Q17381
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcription factor required for formation of the pharyngeal primordium (PubMed:7607089, PubMed:18448117). Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression (PubMed:18448117). Becomes associated with pharyngeal target promoters by the 8E cell stage, playing a role in inducing large-scale chromatin decompaction, prior to the activation of transcription (PubMed:20714352). Binding with target sequences in pharyngeal cells may be repressed by the nuclear lamina protein emr-1 (PubMed:20714352). Activates a wide array of pharyngeal genes including ceh-22, pax-1 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate (PubMed:11823633, PubMed:20714352, PubMed:9584117, PubMed:14738885). Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regulation of diet-restriction-mediated longevity by increasing expression of sod-1, sod-2, sod-4 and sod-5 but not sod-3 (PubMed:17476212). Positively regulates the expression of the transcription factor hlh-6 in the pharyngeal gland (PubMed:17049341). May regulate gene expression in the intestine (PubMed:18448117).
messages: Expression first seen at the 8E cell stage in the embryonic gut. After hatching, expression is almost diminished in the pharynx and gut. Expressed in L3/L4 larvae in cells of the developing gonad. At the 8-12E stage, expression is seen for the first time in the rectal precursors. Intestinal expression is down-regulated during the larval to adult transition.
messages: Interacts with elt-2.
messages: Nucleus
messages: Strongly expressed in the embryonic pharynx, particularly pharyngeal primordium precursor cells. Expression less strong in the embryonic gut. Expressed in adult intestine (PubMed:17113066).
messages: Worms are unable to form the pharyngeal primordium with the pharyngeal precursor cells, ABaraapapaa and ABaraapppaa showing arrested development prior to terminal cell division. Some mutants exhibit malformed rectal tissues and fail to undergo proper embryonic elongation. RNAi-mediated knockdown at the L1 larval stage reduces survival (PubMed:30965033).

6239:CELE F10C2.7
gene id: 6239:CELE_F10C2.7
uniprot id: P90832
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0513.5
gene id: 6239:CELE_B0513.5
uniprot id: O45228
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate (By similarity). Through proline catabolism, promotes reactive oxygen species (ROS) production and the transcription of skn-1 target genes in response to bacterial infection by P.aeruginosa (PubMed:27974198).
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown reduces the survival incidence, results in increased bacterial load and reduces ROS production following infection by P.aeruginosa (PubMed:27974198). RNAi-mediated knockdown inhibits the nuclear accumulation of the transcription factor skn-1 and reduces the expression of skn-1 transcriptional targets including gst-4 following infection by P.aeruginosa (PubMed:27974198). RNAi-mediated knockdown suppresses the pro-survival effects of the addition of exogenous proline following infection by P.aeruginosa (PubMed:27974198).
messages: Up-regulated by infection with P.aeruginosa.

6239:CELE C37A2.6
gene id: 6239:CELE_C37A2.6
uniprot id: O01503
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. ETFBKMT family.
messages: Probable methyltransferase.

6239:CELE ZK622.1
gene id: 6239:CELE_ZK622.1
uniprot id: Q23554
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE ZK512.1
gene id: 6239:CELE_ZK512.1
uniprot id: P34639
names: Subcellular Location Annotation
messages: Membrane

6239:CELE H36L18.1
gene id: 6239:CELE_H36L18.1
uniprot id: O17913
names: Similarity
messages: Belongs to the peptidase M10A family.

6239:CELE F26E4.8
gene id: 6239:CELE_F26E4.8
uniprot id: H2L2E8
uniprot id: O18688
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6239:CELE C52E4.4
gene id: 6239:CELE_C52E4.4
uniprot id: Q18787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

6239:CELE F59B10.1
gene id: 6239:CELE_F59B10.1
uniprot id: G5EFI7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the MRF family.
messages: Constitutes a precursor of the transcription factor (PubMed:28441531). Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Homotrimer (By similarity). Interacts with myrf-2 (PubMed:28441531). Interacts (via C-terminus) with pan-1 (via LRR regions); the interaction promotes the role of myrf-1 in the synaptic remodeling of DD GABAergic motor neurons at the cell membrane (PubMed:33950834).
messages: In early L1 larvae, expressed in the pharynx, epidermis, and neurons.
messages: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.
messages: Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity.
messages: Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecular Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.
messages: Nucleus
messages: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation (PubMed:28441531). Specifically required for dorsal D (DD) GABAergic motor neurons synaptic rewiring (PubMed:28441531, PubMed:33950834). Acts in complex with myrf-2 paralog (PubMed:28441531).
messages: Widely expressed in many tissues, including neuronal, muscle and epidermal stem cells (PubMed:21989027). In neurons, expressed in dorsal D (DD) GABAergic motor neurons (PubMed:28441531).
messages: Worms show normal dorsal D (DD) GABAergic motor neurons rewiring but show larval lethality. Worms lacking both myrf-1 and myrf-2 display defective DD neurons rewiring.

6239:CELE C17E7.5
gene id: 6239:CELE_C17E7.5
uniprot id: O16388
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE AH6.1
gene id: 6239:CELE_AH6.1
uniprot id: Q09435
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Expressed predominantly in sensory neurons. Expressed asymmetrically in the right ASE (ASER) neuron and bilaterally in ASI and URX neurons. Expressed in PVT and bilaterally in AIY non-sensory neurons. Expressed in intestine.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron (PubMed:19523832).
messages: Membrane
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE Y73F8A.24
gene id: 6239:CELE_Y73F8A.24
uniprot id: D3NQB3
uniprot id: K8ESJ1
uniprot id: K8F7X5
uniprot id: Q9NA35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

6239:CELE F19B6.2
gene id: 6239:CELE_F19B6.2
uniprot id: Q19584
uniprot id: Q9U3I6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UFD1 family.
messages: Cytoplasm
messages: Forms a complex composed of ubxn-3, ufd-1, npl-4.1 and cdc-48.1; within the complex interacts with cdc-48.1 (PubMed:20977550, PubMed:16647269). Interacts with cdc-48.2 (PubMed:16647269). Interacts with npl-4.1 and/or npl-4.2 (PubMed:16647269).
messages: Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338). This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338). During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564). Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564).
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:16647269, PubMed:18728180). In embryos, DNA replication is partially impaired causing a delay in S phase progression in P0, AB and P1 cells; simultaneous RNAi-mediated knockdown of DNA replication checkpoint kinases chk-1 or atl-1 suppresses the delay in S phase (PubMed:18728180). Prevents DNA replication licensing factor cdt-1 down-regulation and causes cdt-1 accumulation on mitotic chromosomes (PubMed:21981920). Impairs dissociation from the chromatin of components of the DNA replication machinery, including cdc-45 and GINS complex component sld-5, resulting in their persistent association with chromatin throughout embryonic mitosis (PubMed:21981920, PubMed:26842564, PubMed:18728180). Abnormal ubxn-3 localization into punctate structures in the nucleus (PubMed:26842564). Reduces npl-4 expression in embryos (PubMed:21981920, PubMed:26842564). RNAi-mediated knockdown in adults causes defects in germline development, induces the unfolded protein response, and causes the accumulation of misfolded protein cpl-1 in the ER (PubMed:16647269, PubMed:20977550, PubMed:22768338).

6239:CELE T24F1.2
gene id: 6239:CELE_T24F1.2
uniprot id: Q22747
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM201 family.
messages: Expressed in pre-comma stage embryos, and in particular in hyp7 hypodermal precursor cells.
messages: Nuclear migration defects in hyp7 hypodermal precursor cells.
messages: Nucleus inner membrane
messages: Plays a role in nuclear migration in hypodermal cells.

6239:CELE F44A2.4
gene id: 6239:CELE_F44A2.4
uniprot id: Q20379
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F10B5.8
gene id: 6239:CELE_F10B5.8
uniprot id: Q9U3K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Nucleus

6239:CELE C08B11.1
gene id: 6239:CELE_C08B11.1
uniprot id: P21541
names: Developmental Stage
names: Function
names: Similarity
names: Subunit
messages: Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment.
messages: Belongs to the zyg-11 family.
messages: Interacts with elc-1. Part of an E3 ubiquitin ligase complex including zyg-11, cul-2 and elc-1.
messages: Maternally expressed but its transcription is not limited to the female germline.

6239:CELE T04A8.12
gene id: 6239:CELE_T04A8.12
uniprot id: Q22141
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).

6239:CELE C29E6.1
gene id: 6239:CELE_C29E6.1
uniprot id: Q27394
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Cleaved at the C-terminal domain.
messages: Expressed in external cuticle-producing epithelial cells including the epidermis, vulva, rectum, excretory duct and excretory pore.
messages: Lethal at the larval stage of development. Defects in the development of the excretory system during embryogenesis and the early stages of larval development. Dilated lumens of both the excretory canal cell and excretory duct which become apparent between the early and mid 3-fold stages of embryogenesis and increases in severity as development progresses. Lumen dialation may be as a result of fluid accumulation due to blockage of the lumen. At around the time of hatching, the autocellular junction, which usually seals the excretory pore tube, is absent. Detached excretory duct and pore cells, which usually connects the excretory canal cell to the outside environment for excretion. Irregular morphology of the epidermis and vulva in larvae at the L1 stage of larval development.
messages: Required for epithelial tube development and shaping (PubMed:27482894, PubMed:33141826). Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell (PubMed:7476875, PubMed:27482894, PubMed:33141826). Also plays a role in cuticle development, alae formation and shaping of the vulval lumen (PubMed:27482894). Required for larval development (PubMed:7476875, PubMed:27482894, PubMed:33141826).
messages: Secreted
messages: Secreted in the region between the embryo and inner layer of the eggshell. Expressed in excretory canal cells of embryos and at the 1.5-fold stage of embryonic development accumulates in the lumen of the excretory duct and pore. Expression ceases in the lumen of the excretory duct and pore prior to cuticle secretion. Thereafter expressed transiently in the lumen of the excretory duct and pore in the latter phase of each subsequent larval developmental stage. During the molt phase of larval development, accumulates in the space in between the new and old cuticles. During the L4 stage of larval development, accumulates in the vulval lumen.
messages: The ZP domain is required for localization at the apical cell membrane, secretion and excretory tube and vulval lumen expansion.
messages: extracellular space

6239:CELE F55G1.2
gene id: 6239:CELE_F55G1.2
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE B0303.2
gene id: 6239:CELE_B0303.2
uniprot id: P34254
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
messages: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism (PubMed:24077178).
messages: Suppressed lifespan extension when exposed to nicotinic acid and nicotinamide. Reduced reactive oxygen species levels when exposed to nicotinic acid.

6239:CELE F35G12.2
gene id: 6239:CELE_F35G12.2
uniprot id: Q20049
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Mitochondrion

6239:CELE F25H2.11
gene id: 6239:CELE_F25H2.11
uniprot id: Q93573
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Cytoplasm
messages: Involved in calcium binding and microtubule stabilization.

6239:CELE C38C10.1
gene id: 6239:CELE_C38C10.1
uniprot id: Q03566
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Not known. Putative receptor.

6239:CELE C01A2.7
gene id: 6239:CELE_C01A2.7
uniprot id: G3MU46
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the ventral and dorsal nerve cords and ventral nerve cord motor neurons (PubMed:30779740). Also expressed in tail neurons and head neurons including SAB and DBI motor neurons (PubMed:30779740).
messages: Neuropeptide ligand for the G-protein coupled receptor sprr-2.
messages: Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning.
messages: Secreted

6239:CELE E03A3.2
gene id: 6239:CELE_E03A3.2
uniprot id: Q19046
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

6239:CELE R10E4.4
gene id: 6239:CELE_R10E4.4
uniprot id: Q21902
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order mcm2-mcm6-mcm4-mcm7-mcm3-mcm5 (By simililarity).
messages: Nucleus
messages: cytosol

6239:CELE F16B12.8
gene id: 6239:CELE_F16B12.8
uniprot id: G5EE08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C37H5.5
gene id: 6239:CELE_C37H5.5
uniprot id: P91136
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

6239:CELE C26F1.10
gene id: 6239:CELE_C26F1.10
uniprot id: Q18234
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Exacerbates bordering behavior, where animals accumulate at the edges of culture media (PubMed:14555955). Enhances clumping/aggregation behavior in a G-protein coupled receptor npr-1 mutant background (PubMed:14555955). Decreases locomotion quiescence, in an npr-1 mutant background, during the sleep-like state called lethargus which occurs during molting between larval and adult stages (PubMed:23764289).
messages: Expressed in the ADL, ASE and ASH sensory neurons, the URA motor neurons and the MC, M2 and M4 pharyngeal neurons.
messages: FMRFamide-like neuropeptide (PubMed:12821653, PubMed:14555955). Involved in modulating locomotion quiescence during the sleep-like state called lethargus which occurs during molting between larval and adult stages, acting via the G-protein coupled receptor npr-1 (PubMed:23764289). Plays a role in modulating social and feeding behavior (PubMed:14555955).
messages: It has been reported that many phenotypes associated with the Bristol N2 reference allele of the receptor npr-1 may reflect a neomorphic gain-of-function sensitivity of the receptor to flp-18 in addition to sensitivity to flp-21.
messages: Ligand to G-protein coupled receptor npr-1.
messages: May be processed by convertase egl-3.
messages: Secreted

6239:CELE B0365.3
gene id: 6239:CELE_B0365.3
uniprot id: P90735
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane

6239:CELE B0286.3
gene id: 6239:CELE_B0286.3
uniprot id: Q10457
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

6239:CELE C18A3.4
gene id: 6239:CELE_C18A3.4
uniprot id: Q18071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST-alpha family.
messages: Cell membrane
messages: Probable transporter.

6239:CELE R13A5.3
gene id: 6239:CELE_R13A5.3
uniprot id: Q95Y92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y57E12AM.1
gene id: 6239:CELE_Y57E12AM.1
uniprot id: Q965T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6239:CELE C14B1.1
gene id: 6239:CELE_C14B1.1
uniprot id: Q17967
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

6239:CELE T08G3.13
gene id: 6239:CELE_T08G3.13
uniprot id: Q7YWU7
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE B0285.5
gene id: 6239:CELE_B0285.5
uniprot id: P46555
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the D-glucuronyl C5-epimerase family.
messages: Cell membrane
messages: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity). Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts (PubMed:26022293).
messages: Expression in comma stage embryos is strong in the hypodermis and intestine and weaker in the head region. In late embryos, larval, and adult stages, expressed primarily in hypodermis and intestine.
messages: Homodimer.
messages: Irregular positioning of the AQR and PQR neurons in larva at the L4 stage.
messages: basement membrane

6239:CELE F25B4.7
gene id: 6239:CELE_F25B4.7
uniprot id: P91270
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

6239:CELE R09G11.1
gene id: 6239:CELE_R09G11.1
uniprot id: Q17374
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Gain of function uncoordinated rubber band response is phenocopied by exposure to the unc-49 agonist muscimol.
messages: Low levels in body-wall muscles, eight vulval muscles, intestinal muscles and anal depressor muscle.
messages: May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex.
messages: May form a complex with sup-9 and unc-93 where sup-10 and unc-93 act as regulatory subunits of the two pore potassium channel sup-9. Sup-10 may regulate sup-9 via sup-18.
messages: Membrane

6239:CELE ZC416.6
gene id: 6239:CELE_ZC416.6
uniprot id: O44183
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE F57B10.3
gene id: 6239:CELE_F57B10.3
uniprot id: G5EFZ1
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Activity is not affected by 2,3-bisphosphoglycerate.
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese or magnesium ions per subunit (By similarity). Cobalt and nickel are less efficient (PubMed:17897734).
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Expressed ubiquitously. High expression levels in the nerve ring region, intestine and body wall muscles.
messages: RNAi knockdown results in embryonic lethality. The few surviving larvae have sluggish movements, abnormal body morphology, developmental arrest and impaired survival.

6239:CELE R13F6.5
gene id: 6239:CELE_R13F6.5
uniprot id: Q21981
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE C33F10.9
gene id: 6239:CELE_C33F10.9
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE F25E2.4
gene id: 6239:CELE_F25E2.4
uniprot id: Q19782
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.

6239:CELE C02F12.10
gene id: 6239:CELE_C02F12.10
uniprot id: A3FPJ2
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: First expressed in comma stage embryos, continuing into young adult hermaphrodites (PubMed:22207033). Expressed in the single interneuron DVC, in the tail ganglion, from larval L3 stage and throughout lifetime (PubMed:22207033). Expressed in the ut2 and ut3 cells in the uterus in young adults (PubMed:22207033).
messages: May interact with homeobox protein ceh-14.
messages: Nucleus
messages: Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1, perhaps acting in concert with homeobox protein ceh-14 (PubMed:22207033). May play a minor role in axon guidance in the DVC interneuron (PubMed:22207033).

6239:CELE F35C8.5
gene id: 6239:CELE_F35C8.5
uniprot id: Q20027
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Membrane
messages: Probable sterol desaturase.

6239:CELE Y73E7A.3
gene id: 6239:CELE_Y73E7A.3
uniprot id: G4SSQ1
uniprot id: W6RRP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

6239:CELE F01D5.9
gene id: 6239:CELE_F01D5.9
uniprot id: Q9XVA6
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C33A12.6
gene id: 6239:CELE_C33A12.6
uniprot id: A0A061AKV1
uniprot id: Q18361
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE C18F10.6
gene id: 6239:CELE_C18F10.6
uniprot id: P46572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F30A10.9
gene id: 6239:CELE_F30A10.9
uniprot id: Q93638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

6239:CELE K02D10.5
gene id: 6239:CELE_K02D10.5
uniprot id: P83351
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: RNAi-mediated knockdown results in the aberrant secretion and processing of the aspartic protease hrg-7 with accumulation of hrg-7 in its immature uncleaved form and in the intestine.
messages: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. Plays a role in the processing and secretion of the aspartic protease hrg-7 from the intestine (PubMed:28581477).
messages: synaptosome

6239:CELE F46A8.10
gene id: 6239:CELE_F46A8.10
uniprot id: Q9XV36
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE F37D6.6
gene id: 6239:CELE_F37D6.6
uniprot id: G5EDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

6239:CELE C32E8.10
gene id: 6239:CELE_C32E8.10
uniprot id: Q9XZI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin.
messages: Belongs to the PICALM/SNAP91 family.
messages: Binds clathrin and phosphatidylinositol 4,5-bisphosphate.
messages: Golgi apparatus
messages: High levels in the nervous system and at lower levels in other tissues. In neurons, enriched at presynaptic terminals and is also present in cell bodies.
messages: clathrin-coated pit
messages: clathrin-coated vesicle

6239:CELE T01B4.1
gene id: 6239:CELE_T01B4.1
uniprot id: Q22042
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C18H9.7
gene id: 6239:CELE_C18H9.7
uniprot id: Q09485
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Tissue Specificity
messages: Belongs to the RAPsyn family.
messages: Expressed in muscles and neurons.
messages: Mutants are resistant to levamisole, an agonist of nAChRs.
messages: Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction.
messages: Ubiquitinated by the BCR(kel-8) complex in the absence of unc-29, leading to its degradation.

6239:CELE F08F1.5
gene id: 6239:CELE_F08F1.5
uniprot id: O17386
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Cell membrane
messages: Cleavage by ced-3 activates ced-8 function in promoting phosphatidylserine exposure at the surface of apoptotic cells.
messages: Delayed cell death process.
messages: Phospholipid scramblase that acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:24225442, PubMed:23845944). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:24225442, PubMed:23845944). Regulates apoptosis kinetics during embryonic development (PubMed:10882128, PubMed:1936965, PubMed:24225442, PubMed:23845944). Not required for engulfment of germ cell corpses (PubMed:9927601).

6239:CELE F15D4.4
gene id: 6239:CELE_F15D4.4
uniprot id: Q93512
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y82E9BR.15
gene id: 6239:CELE_Y82E9BR.15
uniprot id: Q9BKS1
names: Similarity
messages: Belongs to the SKP1 family.

6239:CELE T14G8.3
gene id: 6239:CELE_T14G8.3
uniprot id: Q22515
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE F32D1.9
gene id: 6239:CELE_F32D1.9
uniprot id: A0A164D3G3
uniprot id: O16293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

6239:CELE F29D11.2
gene id: 6239:CELE_F29D11.2
uniprot id: G5EFJ4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome
messages: Component of the condensin I complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non-SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:19781752, PubMed:19119011). Within the complex, interacts with dpy-26, mix-1, smc-4 and dpy-28 (PubMed:19781752, PubMed:19119011, PubMed:28301465). Component of the dosage compensation complex, which consists of the condensin I-like components mix-1/SMC2 and dpy-27/SMC4, and the three non-SMC subunits dpy-26, capg-1 and dpy-28 (PubMed:19119011). Within the complex, interacts with mix-1, dpy-27, dpy-26 and dpy-28 (PubMed:19119011, PubMed:28301465). Interacts with smcl-1 (PubMed:28301465).
messages: Expressed in embryos and in somatic and germline tissues in adult animals (at protein level).
messages: Member of two distinct condensin I complexes, the condensin I complex and the condensin I-like dosage compensation complex (PubMed:19781752, PubMed:19119011). The condensin I complex is required for conversion of interphase chromatin into mitotic-like condensed chromosomes and for chromosome segregation in meiosis and mitosis (PubMed:19781752, PubMed:19119011). As a member of the condensin I complex, further controls crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure (PubMed:19781752). Regulatory subunit of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:19119011).
messages: RNAi-mediated knockdown disrupts X-chromosome localization of dpy-27, mix-1, dpy-26 and sdc-3. Results in chromosome segregation defects in mitosis leading to aneuploidy. In a sex-1 mutant background, leads to high embryonic lethality.

6239:CELE F26F2.7
gene id: 6239:CELE_F26F2.7
uniprot id: Q9U3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

6239:CELE Y41E3.10
gene id: 6239:CELE_Y41E3.10
uniprot id: Q9U2H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

6239:CELE Y43F8C.12
gene id: 6239:CELE_Y43F8C.12
uniprot id: Q9U2G5
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Expressed in head neurons, including the dopamine (DA) motor neuron, and other cells in the body.
messages: Negatively regulates cellular toxicity by mediating the export of environmental toxicants such as methylmercury out of the cell (PubMed:24266639). Plays a role in inhibiting methylmercury-induced dopamine (DA) motor neuron degeneration (PubMed:24266639). Not involved in Mn(2+)- or Al(3+)-associated toxicity (PubMed:24266639).
messages: RNAi-mediated knockdown results in increased death in response to the environmental toxicant methylmercury (PubMed:24266639). Furthermore, in response to methylmercury, RNAi-mediated knockdown results in the accumulation of the methylmercury in cells, the subsequent increase of gst-1, hsp-4, hsp-6, and hsp-16.1 gene expression, and in dopamine (DA) motor neuron degeneration (PubMed:24266639).
messages: Up-regulated in response to environmental toxicants such as methylmercury.

6239:CELE F58A4.8
gene id: 6239:CELE_F58A4.8
uniprot id: P34475
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Expressed in between seam cells at the lima-bean, 1.5-fold and 3-fold stages of embryonic development.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
messages: adherens junction
messages: centrosome
messages: hemidesmosome

6239:CELE F52E1.10
gene id: 6239:CELE_F52E1.10
uniprot id: Q20666
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE K07F5.22
gene id: 6239:CELE_K07F5.22
uniprot id: Q8WQE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

6239:CELE Y41C4A.14
gene id: 6239:CELE_Y41C4A.14
uniprot id: G5EC44
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rad1 family.
messages: May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:12445383, PubMed:16951081). Promotes DNA double strand break-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability (PubMed:10882129, PubMed:10646593, PubMed:16951081). Also required for telomere length maintenance and germline immortality (PubMed:10646593, PubMed:16951081, PubMed:22547822). May possess 3'->5' double stranded DNA exonuclease activity (By similarity).
messages: Nucleus
messages: Probable component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of hpr-9, mrt-2 and hus-1 (PubMed:12445383). Interacts with hus-1 (PubMed:12445383). Might associate with hpr-9 (Probable).
messages: RNAi-mediated knockdown disrupts hus-1 localization to the nucleus.

6239:CELE T05A7.5
gene id: 6239:CELE_T05A7.5
uniprot id: G5EEE1
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Expressed in larvae and adult.
messages: Golgi stack membrane
messages: Inhibited by divalent metal cations.
messages: Involved in the fucosylation of N-glycans (PubMed:15364955, PubMed:17369288, PubMed:23754284, PubMed:26538210, PubMed:26002521). Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the distal GlcNAc residue in N-glycans (PubMed:23754284). Catalyzes the transfer of fucose to Gal-beta-1-4-GlcNAc-alpha-pNP (LN-pNP) and Gal-beta-1-4-GlcNAc-beta-1-3-Gal-beta-1-4-Glc (LNnT) (PubMed:17369288). Unlike alpha-(1,3)-fucosyltransferase fut-1, does not transfer fucose to Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-GlcNAc-beta-1-Asn (M3), Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (M3F6) and GlcNAc-beta-1-2-Man-alpha-1-3-(GlcNAc-beta-1-2-Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (GnM3F6) (PubMed:17369288).
messages: No visible phenotype (PubMed:17369288). Loss of several tetra-fucosylated N-glycans (PubMed:15364955). Loss of tetra- and tri-fucosylated N-glycans in a fut-8 or fut-1 mutant background (PubMed:26538210). fut-1, fut-6 and fut-8 triple mutants lack all N-glycan core fucose with only one fucose present in the bisecting galactose, thus resulting in the loss of tetra-, tri- and bi-fucosylated N-glycans (PubMed:26002521).
messages: Unlike other alpha-(1,3)-fucosyltransferases, appears not to require a divalent metal cation as cofactor.

6239:CELE Y47G6A.4
gene id: 6239:CELE_Y47G6A.4
uniprot id: Q9N3S2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the maelstrom family.
messages: In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets.
messages: Insensitive to RNAi-mediated gene silencing.
messages: Interacts with rde-11 (via RING-type zinc finger domain) (PubMed:22508728, PubMed:22542102). Interacts with ergo-1 (PubMed:22542102).

6239:CELE C30F2.1
gene id: 6239:CELE_C30F2.1
uniprot id: Q18327
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE F57C12.5
gene id: 6239:CELE_F57C12.5
uniprot id: Q3S1M2
uniprot id: Q7YZW1
uniprot id: Q8MQ16
uniprot id: Q95QE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE F11H8.1
gene id: 6239:CELE_F11H8.1
uniprot id: Q19360
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric rfl-1 (uba-3)-ula-1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba-3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc-12 (By similarity). Required for cytokinesis and mitotic spindle orientation during early embryogenesis (PubMed:11847342, PubMed:19528325).
messages: Cytoplasm
messages: Expressed in intestine, vulva epithelium and head and tail neurons.
messages: Expressed throughout development.
messages: Heterodimer of uba-3 and ula-1. Interacts with NEDD8 and ubc-12 (By similarity).
messages: Nucleus
messages: RNAi-mediated knockdown results in temperature-sensitive embryonic lethality.

6239:CELE R03A10.1
gene id: 6239:CELE_R03A10.1
uniprot id: Q21655
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

6239:CELE K02A2.7
gene id: 6239:CELE_K02A2.7
uniprot id: G4RX35
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE R04D3.9
gene id: 6239:CELE_R04D3.9
uniprot id: Q21717
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F56H11.4
gene id: 6239:CELE_F56H11.4
uniprot id: G5EEE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme that catalyzes the elongation of monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Membrane

6239:CELE ZK384.6
gene id: 6239:CELE_ZK384.6
uniprot id: G5EC01
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE F54C9.10
gene id: 6239:CELE_F54C9.10
uniprot id: Q20758
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed at low levels in hyp8-11 tail tip cells during the early L4 larval stage (PubMed:21408209). Occassionally, expression is high in hyp10 tail top cells during this time (PubMed:21408209).
messages: Expressed in neuronal cells (PubMed:21408209). Expression in hypodermal tissues is absent (PubMed:21408209).
messages: GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: Golgi apparatus
messages: RNAi-mediated knockdown results in male tail tip defects.

6239:CELE D1007.2
gene id: 6239:CELE_D1007.2
uniprot id: O01873
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE T01B7.5
gene id: 6239:CELE_T01B7.5
uniprot id: Q22046
uniprot id: Q58AA7
names: Similarity
messages: Belongs to the SAS10 family.

6239:CELE R06B10.4
gene id: 6239:CELE_R06B10.4
uniprot id: G5EE02
uniprot id: Q8I6Y9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0491.1
gene id: 6239:CELE_B0491.1
uniprot id: Q17515
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

6239:CELE C48D1.3
gene id: 6239:CELE_C48D1.3
uniprot id: O02228
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Detected in the nervous system, including the nerve ring and cholinergic motor neurons of the ventral nerve cord.
messages: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.
messages: Membrane

6239:CELE C50H2.1
gene id: 6239:CELE_C50H2.1
uniprot id: G5EG04
uniprot id: L8EC40
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE M02H5.1
gene id: 6239:CELE_M02H5.1
uniprot id: Q966H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C49C8.4
gene id: 6239:CELE_C49C8.4
uniprot id: Q27482
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F44B9.6
gene id: 6239:CELE_F44B9.6
uniprot id: P34427
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in vulval precursor P(3-8).p cells and their descendants, neurons of the head, tail and ventral cord, hypodermal and intestinal cells and germline cells.
messages: Nucleus
messages: Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously.

6239:CELE F57B10.5
gene id: 6239:CELE_F57B10.5
uniprot id: O44738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6239:CELE F33D11.5
gene id: 6239:CELE_F33D11.5
uniprot id: O44773
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F45G2.4
gene id: 6239:CELE_F45G2.4
uniprot id: O62246
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).

6239:CELE C40C9.2
gene id: 6239:CELE_C40C9.2
uniprot id: Q18556
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE Y47D3B.7
gene id: 6239:CELE_Y47D3B.7
uniprot id: Q9XX00
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Broadly expressed, including many cells in the head (PubMed:33370778). Expressed in the intestine (PubMed:12530969).
messages: Endoplasmic reticulum membrane
messages: Expression increased by oxygen deprivation (PubMed:19187779). Expression increased by glucose or fructose supplementation (PubMed:19936816, PubMed:29113111). Expression increased by simulated microgravity (PubMed:32448509).
messages: Key transcription factor that regulates expression of genes involved in sterol biosynthesis and lipid homeostasis.
messages: Nucleus
messages: Precursor of the transcription factor form, which is embedded in the endoplasmic reticulum membrane (By similarity). Processing of this form allows release of the transcription factor form that translocates into the nucleus and activates transcription of genes involved in sterol biosynthesis and lipid homeostasis (By similarity).
messages: Processed in the Golgi apparatus, releasing the protein from the membrane.
messages: RNAi-mediated knockdown causes early larval arrest and a pale, skinny appearance; paleness due to absence of dark, lipid-laden fat granules from the intestine (PubMed:12530969, PubMed:19936816). Decrease in body size, delayed growth, fewer eggs laid and 5-6 days after being laid, many eggs hatch inside the body (PubMed:19936816). Exposure to oleic or linoleic acid returns body size almost to normal and also increases number of eggs laid (PubMed:19936816). In normoxic conditions, reduces total fat levels, but has no effect in anoxia (PubMed:19187779). Reduces the increase in body width/length ratio caused by anoxia (PubMed:19187779). Alters fatty-acid composition, including of monomethyl branched-chain fatty acids (mmBCFAs) (PubMed:15340492). Exacerbates induction of reactive oxygen species (ROS) production and decrease in locomotion behavior caused by simulated microgravity (PubMed:32448509). Knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229). Tissue-specific knockdown in any of several different tissues abolishes elevated levels of H3K4me3 modification (PubMed:35140229).
messages: Transcription factor involved in maintaining normal fat levels (PubMed:19187779). Regulates the expression of genes involved in lipid metabolism in response to nutrient availability, such as the fatty-acid desaturases fat-5, fat-6 and fat-7 (PubMed:12530969, PubMed:19936816). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation, acting in concert with transcription factor mxl-3 (PubMed:29113111). Plays a role in synthesis of monomethyl branched-chain fatty acids (mmBCFAs) as well as other very-long-chain fatty acids (PubMed:15340492). Downstream of the cis-Golgi membrane protein eas-1/GOLT1B and the E3 ubiquitin ligase rnf-145/RNF145, plays a role in the regulation of glial size, perhaps by modulating synthesis of long-chain polyunsaturated fatty-acids (LC-PUFA) (PubMed:33370778). Modulates expression of genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAM) (PubMed:22035958). Probably involved in a feedback loop in which decreased levels of SAM lead to increased transcriptional activity of sbp-1, thereby causing lipid accumulation (PubMed:22035958). Involved in the negative regulation of zinc homeostasis (PubMed:28710073). Involved in the response to simulated microgravity, in concert with Mediator complex subunit mdt-15, probably acting in the intestine (PubMed:32448509). Plays a role in transgenerational lipid accumulation in response to a high-fat diet, probably acting by upregulating wdr-5.1 expression to increase the level of trimethylated 'Lys-4' histone H3 (H3K4me3), which may then induce the expression of fat-5, fat-6 and fat-7 (PubMed:35140229). May act as an oxygen sensor for lipid metabolism (PubMed:19187779).
messages: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus.

6239:CELE C44E4.6
gene id: 6239:CELE_C44E4.6
uniprot id: O01805
names: Function
names: Similarity
messages: Belongs to the ACBP family.
messages: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.

6239:CELE T07A9.3
gene id: 6239:CELE_T07A9.3
uniprot id: O44408
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by mek-1 mediated phosphorylation. No differences in basal activation between larvae and adults (PubMed:22554143). Inhibited by phosphatase vhp-1 (PubMed:15116070).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: By B.thuringiensis pore-forming toxin Cry5B.
messages: Cytoplasm
messages: Expressed in somatic and germline tissues.
messages: Interacts with glh-1, glh-2 (via C-terminus), glh-3 (via C-terminus) and glh-4 (via C-terminus) (PubMed:12435362, PubMed:17699606). Interacts with csn-5; the interaction may prevent glh-1 degradation induced by kgb-1 (PubMed:17699606). Interacts with fos-1 (PubMed:23437011).
messages: May be phosphorylated by mek-1 on Ser-198 and/or Tyr-200 (PubMed:15116070). Phosphorylation is induced upon Cu(2+) and arsenite-mediated cell stimulation and by fasting (PubMed:15116070, PubMed:23352664).
messages: Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:22554143, PubMed:23352664). Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2 (PubMed:23437011). Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1 (PubMed:23352664). Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome (PubMed:17699606). Required for oogenesis and probably also for spermatogenesis (PubMed:12435362). Involved in the response to environmental stress such as heavy metals, infection and protein folding stress in an age-dependent manner (PubMed:15116070, PubMed:22554143). In larvae, has a protective role which becomes detrimental in adults (PubMed:22554143). May control susceptibility to infection, heavy metal stress and premature lethality by regulating daf-16 cellular localization (PubMed:22554143). Involved in the transcriptional response to bacterial pore-forming toxins and to fasting (PubMed:15256590, PubMed:21408619, PubMed:23352664). Required for fasting-induced longevity (PubMed:23352664). Involved in axon regeneration after injury downstream of tyrosine receptor svh-2 (PubMed:21670305, PubMed:22388962).
messages: Temperature-sensitive sterility in both hermaphrodites and males which, in hermaphrodites, is associated with disorganized gonads and with impaired production of endomitotic oocytes, likely due to a defect in oocyte maturation which often results in vulva protrusion (PubMed:12435362). Both hermaphrodites and males produce sperm but it is defective (PubMed:12435362). In addition, the formation of P granules is disrupted in later stage of oogenesis and the protein levels of glh-1, a component of the P granules, are increased (PubMed:12435362, PubMed:17699606). Old adults are bloated and move more slowly (PubMed:17699606). Hypersensitivity and impaired up-regulation of several genes in response to heavy metals (Cu(2+) and Cd(2+)) and to bacterial pore-forming toxins exposure (PubMed:15256590, PubMed:15116070, PubMed:21408619, PubMed:23437011). RNAi knockdown at different developmental stages shows age-dependent defects: larvae are hypersensitive to cadmium and protein folding stress and have a reduced survival capacity but these effects are not observed in adults (PubMed:22554143). Impaired fasting-induced longevity (PubMed:23352664). RNAi knockdown in adults results in increased daf-16 nuclear localization in intestinal cells but not in response to fasting (PubMed:22554143, PubMed:23352664). Mutants have impaired axon regeneration (PubMed:21670305).

6239:CELE K08E4.1
gene id: 6239:CELE_K08E4.1
uniprot id: Q21338
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Interacts with spt-4 to form DSIF. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of cdk-9 and cyclin-T (cit-1.1 or cit-1.2) (By similarity).
messages: May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.
messages: Nucleus
messages: Phosphorylated. Phosphorylation by P-TEFb alleviates transcriptional pausing (By similarity).

6239:CELE F26F4.11
gene id: 6239:CELE_F26F4.11
uniprot id: Q19826
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A (By similarity).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
messages: Nucleus

6239:CELE H24K24.3
gene id: 6239:CELE_H24K24.3
uniprot id: Q17335
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Plays a role in the calcium flux to the cytoplasm in the ASJ sensory neurons upon removal of a nitric oxide stimulus (PubMed:30014846).
messages: Cytoplasm
messages: Homodimer.

6239:CELE Y105E8A.3
gene id: 6239:CELE_Y105E8A.3
uniprot id: Q8WQB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane
messages: trans-Golgi network membrane

6239:CELE T05A7.8
gene id: 6239:CELE_T05A7.8
uniprot id: Q22209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y37E11AR.4
gene id: 6239:CELE_Y37E11AR.4
uniprot id: Q965X7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the NAPE-PLD family.
messages: Binds 2 zinc divalent cations per subunit.
messages: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:25423491). NAEs are bioactive lipids that are involved in diverse physiological processes such as growth and lifespan (PubMed:21562563, PubMed:25423491).
messages: Expressed in interneurons that are in close proximity to the primary sensory neurons (PubMed:21562563). Predominantly expressed in the pharynx but can also be found in cell bodies of the dorsal and ventral nerve cords (PubMed:25423491).
messages: No strong phenotype in the nape-1 deletion mutant, however its overexpression alters growth and lifespan when grown at 25 degrees Celsius compared to 15 degrees Celsius.

6239:CELE C33A11.2
gene id: 6239:CELE_C33A11.2
uniprot id: Q93319
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F26C11.1
gene id: 6239:CELE_F26C11.1
uniprot id: Q09549
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE F44C8.7
gene id: 6239:CELE_F44C8.7
uniprot id: G5EBK5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T01H8.1
gene id: 6239:CELE_T01H8.1
uniprot id: G5EE78
uniprot id: Q21734
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
messages: Activated by multiple phosphorylations on threonine and serine residues.
messages: Autophosphorylated on Ser-422, as part of the activation process.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: RNAi-mediated knockdown in lip-1 and puf-8 double mutant causes a decrease in number of germline tumors and restores normal microtubule organization in spermatocytes.
messages: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 (PubMed:22820175).

6239:CELE C13B7.3
gene id: 6239:CELE_C13B7.3
uniprot id: G5EF74
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE T10B10.1
gene id: 6239:CELE_T10B10.1
uniprot id: Q22369
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE R12E2.5
gene id: 6239:CELE_R12E2.5
uniprot id: O61787
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions (By similarity). Required for signals downstream of defecation clock (Ref.2).
messages: gap junction

6239:CELE T09D3.2
gene id: 6239:CELE_T09D3.2
uniprot id: Q23034
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T19C4.7
gene id: 6239:CELE_T19C4.7
uniprot id: Q95ZN4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the YARP (YGGW-amide related peptide) family.
messages: Expressed in hypoderm.
messages: May have antifungic activity against D.coniospora.
messages: Secreted
messages: Strongly up-regulated upon D.coniospora infection.

6239:CELE F33D4.7
gene id: 6239:CELE_F33D4.7
uniprot id: Q7KPW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE W04C9.2
gene id: 6239:CELE_W04C9.2
uniprot id: Q9TZE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE F37H8.5
gene id: 6239:CELE_F37H8.5
uniprot id: O17861
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GILT family.
messages: Secreted

6239:CELE ZK938.11
gene id: 6239:CELE_ZK938.11
uniprot id: A0A1C3NSJ4
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE F55A8.1
gene id: 6239:CELE_F55A8.1
uniprot id: G5EGF4
uniprot id: U4PMB4
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C03D6.3
gene id: 6239:CELE_C03D6.3
uniprot id: Q17607
uniprot id: Q6A3Q2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus
messages: RNA triphosphatase activity is inhibited by magnesium.

6239:CELE R12A1.4
gene id: 6239:CELE_R12A1.4
uniprot id: Q04457
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Appears in mid-proliferation phase when the developing gut has four to eight cells.
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Endoplasmic reticulum lumen
messages: Expressed only in the intestine.

6239:CELE Y119C1B.4
gene id: 6239:CELE_Y119C1B.4
uniprot id: Q95Y83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Mitochondrion

6239:CELE F32H2.1
gene id: 6239:CELE_F32H2.1
uniprot id: P91868
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs.
messages: Broadly expressed in all tissues, including head, vulva and tail.
messages: Expressed throughout development.
messages: Nucleus
messages: RNAi-mediated knockdown from larval stage L1 results in decreased 21U-RNA expression and disrupted distribution of prde-1 foci within the nuclei of germ cells.

6239:CELE Y57G11C.47
gene id: 6239:CELE_Y57G11C.47
uniprot id: Q7YTI0
names: Similarity
messages: Belongs to the isochorismatase family.

6239:CELE F54F2.8
gene id: 6239:CELE_F54F2.8
uniprot id: P34453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-19 family.
messages: Peroxisome

6239:CELE EEED8.7
gene id: 6239:CELE_EEED8.7
uniprot id: Q09511
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: May play a functionally redundant role in embryogenesis.
messages: Nucleus

6239:CELE C32E8.11
gene id: 6239:CELE_C32E8.11
uniprot id: P91133
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the UBR1 family.
messages: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development (PubMed:28602583). Negatively regulates glutamate metabolism through the aspartate aminotransferase got-1.2 (PubMed:29649217). Modulation of glutamate levels most likely controls locomotory behavior, in particular backwards locomotion or 'reversals' (PubMed:29649217).
messages: Expressed in pharyngeal muscles, body wall muscles and a subset of neurons throughout postembryonic development (PubMed:29649217). Prominently expressed in premotor interneurons, but not expressed in ventral cord motor neurons (PubMed:29649217). Weakly expressed in hypodermal seam cells (PubMed:29649217).
messages: Interacts with ubc-1 (Probable). Component of a complex containing at least ced-3, ubr-1 and possibly ate-1 (PubMed:28602583). Within complex interacts with ced-3 (via the p17 subunit); this interaction is required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 (PubMed:28602583).
messages: Membrane
messages: RNAi-mediated knockdown enhances the excessive seam cell proliferation phenotype of the ain-1 ku322 mutant.
messages: The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.

6239:CELE C34D4.13
gene id: 6239:CELE_C34D4.13
uniprot id: Q18446
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLOC1S5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed at least of blos-1, blos-2, blos-4, dsbn-1, glo-2, mutd-1 and snpn-1.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis.

6239:CELE F07C4.3
gene id: 6239:CELE_F07C4.3
uniprot id: Q9GS04
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE T14G12.4
gene id: 6239:CELE_T14G12.4
uniprot id: Q22510
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in the 4 descendants of the D blastomere in embryos at about the 185 cells stage and in many other unidentified cells located more anteriorly.
messages: Nucleus
messages: RNAi-mediated knockdown by injection into adults causes slow and spatially restricted movement of about 30% of their L1 larval progeny, which nonetheless grow normally and do not display any obvious phenotype as late larvae or adults (PubMed:11044397). However, simultaneous knockdown of forkhead gene pes-1 causes 12% of eggs produced by hermaphrodites to arrest development at late stages of embryogenesis and 81% arrest after hatching as L1 stage larvae (PubMed:11044397).
messages: Transcription factor (By similarity). Plays a role in embryogenesis and later development, perhaps acting redundantly with forkhead protein pes-1 (PubMed:11044397).

6239:CELE M03C11.4
gene id: 6239:CELE_M03C11.4
uniprot id: Q21484
names: Similarity
messages: Belongs to the HAT1 family.

6239:CELE C35E7.10
gene id: 6239:CELE_C35E7.10
uniprot id: H2KZ80
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y38F2AR.2
gene id: 6239:CELE_Y38F2AR.2
uniprot id: Q95XS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

6239:CELE Y87G2A.5
gene id: 6239:CELE_Y87G2A.5
uniprot id: Q9U1Q4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE T01G6.5
gene id: 6239:CELE_T01G6.5
uniprot id: O16965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C49H3.8
gene id: 6239:CELE_C49H3.8
uniprot id: Q9GYR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

6239:CELE K06C4.2
gene id: 6239:CELE_K06C4.2
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y6B3B.5
gene id: 6239:CELE_Y6B3B.5
uniprot id: Q5ZEQ3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

6239:CELE C50F4.3
gene id: 6239:CELE_C50F4.3
uniprot id: Q18740
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE F53A9.4
gene id: 6239:CELE_F53A9.4
uniprot id: Q20687
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

6239:CELE W02D3.12
gene id: 6239:CELE_W02D3.12
uniprot id: Q8MQG6
names: Similarity
messages: Belongs to the SDHAF4 family.

6239:CELE F52E1.13
gene id: 6239:CELE_F52E1.13
uniprot id: H2L003
uniprot id: Q3Y409
names: Similarity
messages: Belongs to the OXR1 family.

6239:CELE VW02B12L.1
gene id: 6239:CELE_VW02B12L.1
uniprot id: G5EGP4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Expressed in P2 cell of 4-cell stage embryo (at protein level) (PubMed:11441002). At the comma stage, expressed in cells in the lateral sides (at protein level) (PubMed:11441002). Specifically expressed in intestine from the 2-fold embryonic stage onwards including in the larval and adult stages (at protein level) (PubMed:11441002, PubMed:19741196).
messages: RNAi-mediated knockdown causes larval lethality at the L1 stage (PubMed:11441002). RNAi-mediated knockdown at the L1 larval stage causes reduced growth rate (PubMed:19741196). The progeny of the few that reach adulthood is arrested at the L1 larval stage (PubMed:19741196). Rhythmic defecation behavior is altered; the defecation cycle period is extended and animals have a slight arrhythmia (PubMed:19741196). In the intestinal epithelium, pH oscillates once per cycle as in the wild-type, but the oscillations are diminished in amplitude and cells are relatively acidic (PubMed:19741196). Also, luminal pH oscillations are reduced (PubMed:19741196). RNAi-mediated knockdown at the L2 larval stage causes a reduction of whole body fat mass in young adults (PubMed:19741196). In some animals, the lumen appears swollen, with a reduction of the cytoplasmic contents of intestinal cells (PubMed:19741196). Defect in nutrient absorption (PubMed:19741196).
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:19741196). In the intestine, required for the rhythmic defecation behavior by promoting acidification in the gut lumen following defecation (PubMed:19741196). Also, luminal acidification is required for nutrient uptake (PubMed:19741196).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunit C vha-11 (PubMed:11441002).

6239:CELE VW02B12L.3
gene id: 6239:CELE_VW02B12L.3
uniprot id: Q9XXA2
names: Similarity
messages: Belongs to the MAPRE family.

6239:CELE R151.9
gene id: 6239:CELE_R151.9
uniprot id: Q21993
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE F41B5.4
gene id: 6239:CELE_F41B5.4
uniprot id: O16670
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F22B3.2
gene id: 6239:CELE_F22B3.2
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C17G10.5
gene id: 6239:CELE_C17G10.5
uniprot id: Q09975
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

6239:CELE C16A3.8
gene id: 6239:CELE_C16A3.8
uniprot id: Q18033
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THOC2 family.
messages: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
messages: Nucleus

6239:CELE T12A2.9
gene id: 6239:CELE_T12A2.9
uniprot id: P46565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE C33G8.1
gene id: 6239:CELE_C33G8.1
uniprot id: Q18402
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R08E3.3
gene id: 6239:CELE_R08E3.3
uniprot id: H2L007
uniprot id: Q7JP60
names: Similarity
messages: Belongs to the CCDC22 family.

6239:CELE W07E11.3
gene id: 6239:CELE_W07E11.3
uniprot id: G5EFN6
names: Disruption Phenotype
names: Function
messages: Acts as a ligand to FMRFamide peptide receptor frpr-18 in vitro.
messages: FMRFamide-like neuropeptides (PubMed:15809090, PubMed:24533288). Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1 (PubMed:27585848). Involved in neural modulation of systemic mitochondrial unfolded protein response (PubMed:27767096).
messages: Knockouts generated by CRISPR-Cas9-mediated gene editing strongly inhibited the peripheral induction of the mitochondrial unfolded protein response.

6239:CELE ZK809.4
gene id: 6239:CELE_ZK809.4
uniprot id: F5GU99
uniprot id: G5EDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE C12D5.7
gene id: 6239:CELE_C12D5.7
uniprot id: Q27470
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F56B3.7
gene id: 6239:CELE_F56B3.7
uniprot id: O45109
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F54F7.10
gene id: 6239:CELE_F54F7.10
uniprot id: B1Q256
names: Similarity
messages: Belongs to the SKP1 family.

6239:CELE F07D3.2
gene id: 6239:CELE_F07D3.2
uniprot id: Q19165
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons. Flp-6 is expressed in the ASE sensory neurons, AFD, ASG, PVT and I1 neurons.
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides. KSAYMRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system.
messages: Secreted

6239:CELE K11D2.5
gene id: 6239:CELE_K11D2.5
uniprot id: Q7YTL5
names: Similarity
messages: Belongs to the mTERF family.

6239:CELE C50B8.3
gene id: 6239:CELE_C50B8.3
uniprot id: Q18726
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIA30 family.
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Required for normal growth and reproduction.
messages: Mitochondrion
messages: RNAi-mediated knockdown impairs mitochondrial complex I assembly. Reduced body size, reduced fat content, fewer embryos and an extended egg laying period. These phenotypes are exacerbated when nuaf-3 is simultaneously knocked down.

6239:CELE R09B5.11
gene id: 6239:CELE_R09B5.11
uniprot id: O44616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Appears to have no transport activity for glucose.
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in seam cells from the early embryonic stage through the L2 stage (at protein level).

6239:CELE F46C8.2
gene id: 6239:CELE_F46C8.2
uniprot id: Q9GYP3
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE W03D2.5
gene id: 6239:CELE_W03D2.5
uniprot id: Q9U7D3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in seam cells, excretory cell, reproductive system, pharynx, pharyngeal-intestinal valve cells, neurons and neuronal support cells.
messages: Expressed in the seam cells of 1.2-fold embryos.
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: Worms either die at embryonic or larval stages (43%), or exhibit variable abnormal morphology.

6239:CELE B0250.5
gene id: 6239:CELE_B0250.5
uniprot id: Q9XTI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
messages: Mitochondrion

6239:CELE R06C7.7
gene id: 6239:CELE_R06C7.7
uniprot id: B2D6M2
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Expressed from the one-cell embryo to the adult (at protein level).
messages: Interacts preferentially with histone H3 that is dimethylated or trimethylated at 'Lys-9'.
messages: Multivulva phenotype in combination with loss of function of class A synMuv genes lin-8, lin-38, lin-56 and lin15A and with the class B synMuv gene hpl-2. Reduction of brood size and defects in the development of germ cells. Loss of function results in suppression of mat-3(ku233) mutant vulval phenotype.
messages: Nucleus
messages: Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.
messages: The MBT repeats specifically recognize and bind histone H3 di- and tri-methylated at 'Lys-9' (H3K9me2/3).

6239:CELE T02B11.8
gene id: 6239:CELE_T02B11.8
uniprot id: Q1XFZ1
names: Similarity
messages: Belongs to the granulin family.

6239:CELE C50F2.10
gene id: 6239:CELE_C50F2.10
uniprot id: G5EC68
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811.
messages: Expressed in all larval and adult stages but not in pre-hatching embryos (at protein level).
messages: Expressed in the pharynx (at protein level). Detected in pharyngeal neurons and secretory cells.
messages: Secreted

6239:CELE K04C2.6
gene id: 6239:CELE_K04C2.6
uniprot id: G5EF25
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T27C5.10
gene id: 6239:CELE_T27C5.10
uniprot id: G5ECH4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F32B6.1
gene id: 6239:CELE_F32B6.1
uniprot id: O45436
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R53.5
gene id: 6239:CELE_R53.5
uniprot id: Q22020
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

6239:CELE C01F6.9
gene id: 6239:CELE_C01F6.9
uniprot id: G5EDA6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6239:CELE Y41G9A.4
gene id: 6239:CELE_Y41G9A.4
uniprot id: A0A0K3ATD8
uniprot id: H2L0Q3
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alpha-helical parts of the C-terminal intracellular region may mediate heterodimeric interaction with gbb-2.
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (By similarity). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (By similarity). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (By similarity). Along with gbb-2, may couple to the G(o)-alpha G-protein goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). As acetylcholine depolarizes body wall muscles, modulation of acetylcholine levels most likely results in the control of locomotory behavior (PubMed:18614679). Acts in neurons to regulate lifespan, and this may be through G-protein-egl-8/PLC-beta signaling to the transcription factor daf-16/FOXO (PubMed:26537867).
messages: Expressed in the nervous system, including cholinergic motor neurons, but not in GABAergic motor neurons or muscle.
messages: Increased lifespan (PubMed:26537867). Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Double knockout with gbb-2 also results in increased sensitivity to Aldicarb and accelerated paralysis, but in addition results in irregular locomotory behavior characterized by increased speed of locomotion, decreased turning frequency, reduced rate of reversals, and an increased maximal distance covered in a 40 second interval (PubMed:18614679). Double knockout with the GABA(A) receptor unc-49 results in body elongation defects in response to induced GABA release of GABAergic motor neurons (PubMed:21613582).
messages: May form a heterodimer with gbb-2.
messages: Membrane

6239:CELE Y47H10A.4
gene id: 6239:CELE_Y47H10A.4
uniprot id: Q9U2B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

6239:CELE F56A8.1
gene id: 6239:CELE_F56A8.1
uniprot id: C0P286
uniprot id: G5EBW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

6239:CELE F49E8.3
gene id: 6239:CELE_F49E8.3
uniprot id: Q4TT88
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Aminopeptidase (PubMed:12930831). Required for the exit from meiosis, probably upstream of cyclin cyb-3 (PubMed:17021038). Involved in the establishment of the anterior-posterior polarity at the embryonic 1-cell stage by regulating the dynamics of sperm-donated centrosomes (PubMed:17021038, PubMed:20599902, PubMed:28065742). Plays a role in oocyte maturation (PubMed:24663498). Required for embryonic development (PubMed:12930831).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit. Can also use Ni(2+) and Co(2+) (PubMed:12930831).
messages: Chromosome
messages: Cytoplasm
messages: Expressed in the 1-cell embryos (at protein level) (PubMed:20599902). Expressed during gastrulation and throughout the larval stage and in adults (PubMed:12930831).
messages: Expressed mainly in intestinal cells in the posterior part of the intestine and in amphid sensory neurons and nerve ring neurons (PubMed:12930831). Expressed in neurons in the male tail (PubMed:12930831). Expressed in mature spermatids (at protein level) (PubMed:20599902).
messages: Inhibited by chelating agent 1,10-phenanthroline, aminopeptidase inhibitors actinonin, amastatin, and leuhistin, and to a lesser extent by puromycin.
messages: RNAi-mediated knockdown causes an arrest at the gastrulation stage in 30 percent of embryos (PubMed:12930831). The surviving adults lay a substantial number of unfertilized oocytes (PubMed:12930831). However, brood size is only slightly reduced (PubMed:24663498). In the gonads, the pachytene zone is expanded in 15 percent of animals and oocyte nucleolus disassembly is delayed (PubMed:24663498). Mutant 1-cell embryos have a delay in meiotic exit during which chromosomes fail to decondense after polar body extrusion and oocyte and sperm pronuclear envelope formation is delayed (PubMed:17021038). In addition, 33 percent of 1-cell embryos have impaired chromosome segregation at meiotic anaphase II (PubMed:17021038). During meiotic exit delay, sperm pronucleus/centrosome complex (SPCC) dissociates prematurely from the posterior cortex resulting in a failure to establish anterior-posterior polarity subsequently leading to a symmetric division in half of the 1-cell embryos (PubMed:17021038, PubMed:20599902, PubMed:28065742). Premature microtubule nucleation prior to the sperm pronuclear appearance occurs (PubMed:17021038, PubMed:20599902). Cortical flows, pseudocleavage and asymmetric localization of par-1, par-2, par-3 and par-6 are absent, and cytoplasmic P granules and pie-1 are mislocalized prior to the first mitotic division (PubMed:17021038, PubMed:20599902, PubMed:28065742). In addition, non-muscle myosin nmy-2 foci fails to clear from the posterior part during polarization in half of the 1-cell embryos (PubMed:28065742). Simultaneous RNAi-mediated knockdown of cyclin cyb-3, causes a failure to extrude the second polar body and prevents anaphase entry in some of the 1-cel embryos (PubMed:17021038). Also restores normal timing for meiotic exit but not the establishment of AP axis polarity (PubMed:17021038). Simultaneous RNAi-mediated knockdown of dynein heavy chain dhc-1, restores anterior-posterior polarity, par-1, par2 and par-6 asymmetric localization and pseudocl…
messages: cell cortex
messages: spindle pole

6239:CELE F25B3.6
gene id: 6239:CELE_F25B3.6
uniprot id: G5EBY0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex which consists of at least cdc-73, ctr-9, leo-1, pafo-1 and rtfo-1.
messages: Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.
messages: Expressed in somatic cells, but not in germ cells, after the 30 cell stage.
messages: Nucleus
messages: RNAi-mediated knock-down is mostly embryonic lethal. Embryogenesis proceeds more slowly, with embryos displaying defects in the positioning and shape of epidermal cells.

6239:CELE C27A2.2
gene id: 6239:CELE_C27A2.2
uniprot id: P52819
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

6239:CELE C14C6.2
gene id: 6239:CELE_C14C6.2
uniprot id: A0A0K3AVD0
uniprot id: O44675
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y50E8A.2
gene id: 6239:CELE_Y50E8A.2
uniprot id: Q9NAF5
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F25C8.5
gene id: 6239:CELE_F25C8.5
uniprot id: Q564U4
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the tubulin--tyrosine ligase family.
messages: Expressed in embryos and adults.
messages: Expressed in head sensory neurons.
messages: Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior (PubMed:27635036). Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth (PubMed:23000142).

6239:CELE R12E2.11
gene id: 6239:CELE_R12E2.11
uniprot id: O61790
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Expressed in body wall muscles, spermatheca and vulva muscles.
messages: Homodimer.
messages: Phosphoribosyltransferase which catalyzes the formation of UMP from uracil in vitro and thus may be involved in UMP biosynthesis via the salvage pathway. May also participate in the first step of UMP synthesis by catalyzing the formation of orotidine 5'-phosphate, a UMP precursor, from orotate.

6239:CELE F23F12.3
gene id: 6239:CELE_F23F12.3
uniprot id: P46499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

6239:CELE T10B11.7
gene id: 6239:CELE_T10B11.7
uniprot id: H2KZ49
names: Disruption Phenotype
names: Function
messages: May play a role in transgenerational epigenetic inheritance.
messages: Mortal germline (Mrt) phenotype in which there is a progressive decline in fertility with each generation at 25 degrees Celsius.

6239:CELE F58H1.6
gene id: 6239:CELE_F58H1.6
uniprot id: Q21015
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE AC3.10
gene id: 6239:CELE_AC3.10
uniprot id: Q5FC64
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Expressed during spermatogenesis in budding and budded spermatids.
messages: Involved in spermatogenesis, specifically in the morphogenesis of fibrous body-membranous organelles (FB-MO), which are Golgi-derived organelles used for transporting sperm-specific components, in spermatocytes and in their localization into budding spermatids (PubMed:16143610, PubMed:2744235). Required for the proper formation of spermatids and spermatozoa (PubMed:2744235).
messages: Membrane
messages: Only expressed during spermatogenesis in adult males and in hermaphrodites in the larval stage 4.
messages: Self-sterile phenotype which is slightly temperature sensitive (PubMed:16143610). In hermaphrodites the temperature sensitivity is restricted to the larval stage 4 when spermatogenesis takes place (PubMed:16143610). Premature disassembly of FB-MO before or while spermatids are budding from spermatocytes (PubMed:2744235). FB remain in spermatocytes whereas MO localize to spermatids but often fail to fuse with plasma membrane (PubMed:2744235). Resulting spermatids are usually smaller than normal and contain several or mislocalized nuclei (PubMed:16143610, PubMed:2744235). Fewer spermatozoa are generated and those that are have abnormally short pseudopods and are immotile (PubMed:2744235). The size of spermatocytes is unaffected (PubMed:2744235). Increased life span and resistance to UV and heat but not to oxidative stress induced by paraquat (PubMed:10638523). Normal production of fertile oocytes (PubMed:10638523).
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE F49B2.6
gene id: 6239:CELE_F49B2.6
uniprot id: G5EGH4
names: Similarity
messages: Belongs to the peptidase M1 family.

6239:CELE Y15E3A.4
gene id: 6239:CELE_Y15E3A.4
uniprot id: Q9U2R3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y110A7A.17
gene id: 6239:CELE_Y110A7A.17
uniprot id: Q9N593
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the APC3/CDC27 family.
messages: Expressed in the ventral nerve cord.
messages: Nucleus
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:12620985, PubMed:11134076). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870).
messages: RNAi-mediated knockdown results in defective metaphase to anaphase transition (Mat phenotype) and embryos that arrest at the one-cell stage.
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE F23F1.5
gene id: 6239:CELE_F23F1.5
uniprot id: O17066
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

6239:CELE C34D4.12
gene id: 6239:CELE_C34D4.12
uniprot id: Q18445
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE T26H10.1
gene id: 6239:CELE_T26H10.1
uniprot id: O76554
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
messages: The functional receptor is a heteromer of deg-3 and des-2. Interacts with ric-3; which is required for proper receptor folding.

6239:CELE Y116A8C.32
gene id: 6239:CELE_Y116A8C.32
uniprot id: G5EF97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

6239:CELE Y46E12BL.1
gene id: 6239:CELE_Y46E12BL.1
uniprot id: Q965N9
names: Similarity
messages: Belongs to the TGF-beta family.

6239:CELE T23H4.1
gene id: 6239:CELE_T23H4.1
uniprot id: E5QCJ1
uniprot id: G5EGL4
uniprot id: P91827
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C09H10.2
gene id: 6239:CELE_C09H10.2
uniprot id: P48166
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

6239:CELE F33H2.1
gene id: 6239:CELE_F33H2.1
uniprot id: O62217
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y65B4BL.2
gene id: 6239:CELE_Y65B4BL.2
uniprot id: Q9N303
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of P-granules which is required for P-granule formation and integrity in adult germ cells (PubMed:18234720). Promotes the accumulation of glh-1 mRNA and localization of pgl-1 to P-granules (PubMed:18234720). Involved in RNA-mediated gene silencing (RNAi) in the germline (PubMed:18234720, PubMed:32843637). In particular, it is required for piwi-interacting RNA (piRNA) gene silencing and positively regulates the formation of secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue (PubMed:32843637). Its role in RNAi may also be through positively regulating the expression of the dsRNA-binding protein rde-4 (PubMed:18234720). Plays a role in small RNA-directed transgenerational epigenetic inheritance (PubMed:27015309, PubMed:29769721).
messages: Cytoplasmic granule
messages: Expressed at all stages of development from embryogenesis to adulthood (PubMed:18234720). Expressed at all embryonic stages (PubMed:18234720).
messages: Expressed in germ cells.
messages: Interacts (via N-terminus) with prg-1; the interaction is direct (PubMed:32843637). May interact with edg-1 (PubMed:32843637).
messages: RNAi-mediated knockdown results in sterility and disrupts the localization of pgl-1 to P-granules at 24.5 degrees Celsius.
messages: perinuclear region

6239:CELE C07H4.2
gene id: 6239:CELE_C07H4.2
uniprot id: G5EGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

6239:CELE Y105C5B.21
gene id: 6239:CELE_Y105C5B.21
uniprot id: A0A078BPM1
uniprot id: A0A078BPN7
uniprot id: A0A078BQQ1
uniprot id: A0A078BS85
uniprot id: D3DEL7
uniprot id: D3DEL8
uniprot id: Q9U308
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associated with the catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2 (PubMed:25938815). Interacts with hmr-1 (PubMed:12847081, PubMed:25938815). Interacts with picc-1 (PubMed:25938815).
messages: Belongs to the beta-catenin family.
messages: Embryos are viable, but display a partial loss of junctional component, pac-1, from adherens junctions.
messages: Epidermal cells.
messages: Expressed in the early epidermis.
messages: May act as a positive modulator of hmr-1 function during epidermal morphogenesis (PubMed:12847081). Required for proper localization of other junctional components, such as pac-1 (PubMed:25938815).
messages: Nucleus
messages: adherens junction

6239:CELE Y74C10AR.1
gene id: 6239:CELE_Y74C10AR.1
uniprot id: Q965S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE F01F1.9
gene id: 6239:CELE_F01F1.9
uniprot id: Q19087
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Plays a role in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo.
messages: Animals are viable. Suppresses the abnormal formation of intestinal vacuoles phenotype in mutants lacking the phospholipid-transporting ATPase tat-1 or its chaperone chat-1.
messages: Belongs to the peptidase M18 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Expressed from the embryonic stage to adulthood.
messages: Expressed in various cell types and tissues including the pharynx, neurons, body wall muscle, intestine and vulva.
messages: Tetrahedron-shaped homododecamer built from six homodimers.
messages: cytosol

6239:CELE C27D6.3
gene id: 6239:CELE_C27D6.3
uniprot id: Q10032
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK1127.2
gene id: 6239:CELE_ZK1127.2
uniprot id: Q23404
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE Y39A1A.15
gene id: 6239:CELE_Y39A1A.15
uniprot id: Q9XX14
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the centaurin gamma-like family.
messages: During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis.
messages: GTPase-activating protein for the ADP ribosylation factor family (Probable). During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis. In oocytes, involved in vitellogenin vit-2 uptake by regulating receptor rme-2 endocytosis.
messages: RNAi-mediated knockdown in a ced-3 n2436 mutant background results in the production of extra A/PVM neurons; the precursor Q.pp, which is normally fated to die, acquires the fate of its sister Q.pa.
messages: The N-terminal domain is required for the positive control of neuroblast asymmetric divisions.

6239:CELE ZK678.2
gene id: 6239:CELE_ZK678.2
uniprot id: Q94411
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F35E8.12
gene id: 6239:CELE_F35E8.12
uniprot id: O45449
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE C06A12.3
gene id: 6239:CELE_C06A12.3
uniprot id: D3YT87
uniprot id: D3YT88
uniprot id: Q9XU41
names: Similarity
messages: Belongs to the GSKIP family.

6239:CELE F43B10.2
gene id: 6239:CELE_F43B10.2
uniprot id: Q1XFY2
uniprot id: Q9TZM9
names: Similarity
messages: Belongs to the PAF1 family.

6239:CELE F56E10.1
gene id: 6239:CELE_F56E10.1
uniprot id: A0A0K3AS47
uniprot id: A0A0K3AUI7
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE CD4.4
gene id: 6239:CELE_CD4.4
uniprot id: O44158
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Late endosome membrane

6239:CELE F26F4.13
gene id: 6239:CELE_F26F4.13
uniprot id: Q8MNT1
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

6239:CELE R12E2.3
gene id: 6239:CELE_R12E2.3
uniprot id: O61792
names: Similarity
messages: Belongs to the peptidase M67A family.

6239:CELE M02H5.6
gene id: 6239:CELE_M02H5.6
uniprot id: A0A0K3ASR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK593.4
gene id: 6239:CELE_ZK593.4
uniprot id: A0A061ACP3
uniprot id: Q23541
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JARID1 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:17320161). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20' (PubMed:17320161). Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161). Required for normal longevity of the soma in a germline-dependent manner (PubMed:20555324, PubMed:22212395). Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258). Involved in larval development and vulva formation (PubMed:17320161).
messages: Nucleus
messages: RNAi-mediated knockdown decreases lifespan in wild type worms with an intact germline (PubMed:20555324). Results in extended lifespan when egg production is inhibited by the addition of floxuridine (FUDR) or in a glp-1 mutant background which lacks a germline (PubMed:22212395, PubMed:20555324).

6239:CELE Y97E10B.1
gene id: 6239:CELE_Y97E10B.1
uniprot id: Q965R1
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE ZC250.3
gene id: 6239:CELE_ZC250.3
uniprot id: O01879
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK616.10
gene id: 6239:CELE_ZK616.10
uniprot id: Q65XX7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed during embryogenesis (at protein level) (PubMed:20026024). First expressed shortly after the assembly of the gonad primordium (PubMed:15294864). Expressed in somatic gonadal precursor (SGP) cells in embryos and L1 stage larvae (PubMed:20026024, PubMed:24402584). Expressed in daughter cells of SGP cells throughout the L1 larval stage (PubMed:20026024).
messages: Nucleus
messages: RNAi-mediated knockdown results in abnormal gonadal development in 10% of animals whereby gonads fail to divide or grow in size (PubMed:15294864). This abnormality is enhanced in a tra-1 (e1099) mutant background and is accompanied by masculinization of gonadal tissues (PubMed:15294864).
messages: Required for proper gonadal primordium assembly and somatic gonad precursor cell morphology.
messages: Together with the zinc finger protein ztf-16, plays a role in gonadogenesis, specifically in somatic gonad precursor cell development (PubMed:12756172, PubMed:15294864, PubMed:20026024, PubMed:24402584). This is possibly by regulating tra-1 gene expression (PubMed:15294864).

6239:CELE F42D1.3
gene id: 6239:CELE_F42D1.3
uniprot id: Q93704
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Expressed in head neurons including the ASE sensory neurons and the ASI and AWB chemosensory neurons, the midbody neurons SDQ, and motor neurons in the tail.
messages: G-protein coupled receptor for the neuropeptide like protein nlp-38 (PubMed:30779740). Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning (PubMed:30779740). Its role in salt avoidance learning may be through activation of the transcription factor crh-1/CREB and de novo transcription and translation, which in turn promotes the formation of long-term memory (PubMed:30779740).

6239:CELE C17G10.1
gene id: 6239:CELE_C17G10.1
uniprot id: Q09973
names: Similarity
messages: Belongs to the TPA1 family.

6239:CELE Y71G12B.1
gene id: 6239:CELE_Y71G12B.1
uniprot id: Q95XL8
uniprot id: Q95XL9
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F02A9.10
gene id: 6239:CELE_F02A9.10
uniprot id: P34385
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AccD/PCCB family.
messages: Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.
messages: Mitochondrion matrix

6239:CELE F44A6.2
gene id: 6239:CELE_F44A6.2
uniprot id: P41830
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Most abundant in embryos.
messages: Nucleus
messages: RNAi-mediated knockdown results in 43% lethality of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown together with fox-1 results in hermaphrodite embryonic lethality (PubMed:21471153, PubMed:33372658). This hermaphrodite-specific lethality is suppressed in a sea-2 bp283 mutant or sea-1 gk799 mutant background (PubMed:21471153). RNAi-mediated knockdown results in hermaphrodites lethality due to failure of the dosage compensation complex to assemble on X chromosomes in a fox-1 y303 mutant background (PubMed:17720939). RNAi-mediated knockdown in a background containing one copy of the fox-1 gene results in the viability of 3% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of the xol-1 gene have been mutated to AUACA and AUAUA, respectively results in the viability of 1% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUACA and AUAUA, respectively results in the viability of 7% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG motifs in intron 6 of the xol-1 gene have been mutated to AUACA results in the viability of 24% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUACA results in the viability of 18% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCUAG motifs in intron 6 of the xol-1 gene have been mutated to AUAUA results in the viability of 33% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCUAG motifs in intron 6 of one copy of the xol-1 gene have been mutated to AUAUA results in the viability of 13% of hermaphrodites (PubMed:33372658). RNAi-mediated knockdown in a strain where all of the GCACG and GCUAG …
messages: Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways (PubMed:21471153, PubMed:23666922, PubMed:16139225, PubMed:17720939, PubMed:33372658). Directly binds to five 5'-A(G/C)(G/T)(T/G)C(A/G)-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development (PubMed:23666922). Together with fox-1 is involved in making the distinction between one and two X-chromosomes (PubMed:21471153, PubMed:23666922, PubMed:33372658). Plays a role in the fox-1-mediated repression of the functionally active isoform (isoform b) of the sex-determining factor xol-1 gene to promote hermaphrodite development (PubMed:33372658). Plays a role in the association of the dosage compensation complex proteins dpy-27 and sdc-3 with the hermaphrodite X chromosomes (PubMed:16139225, PubMed:17720939).

6239:CELE F28D1.1
gene id: 6239:CELE_F28D1.1
uniprot id: Q19873
names: Subcellular Location Annotation
messages: nucleolus

6239:CELE F33E2.2
gene id: 6239:CELE_F33E2.2
uniprot id: O01700
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: By forming heterooligomers with isoform a, acts as an inhibitor of isoform a activation. Its inhibitory function is independent of its catalytic activity.
messages: Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation (PubMed:15707898). Phosphorylates and activates mkk-4 (PubMed:15707898). Has a role in axonal regrowth following injury and synaptogenesis (PubMed:19737525, PubMed:19164707). Plays a role in modulating polymerization of neuronal microtubules (PubMed:21368137). Also promotes tubulin post-translational modifications that protect microtubules (PubMed:23000142). Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis, and may also have a role in intraflagellar transport in cilia (PubMed:26657059). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
messages: Cytoplasm
messages: Expressed in nerve ring, nerve cord, neurons, and pharynx.
messages: Has a role in synapse and axon development, and in axonal regrowth following injury.
messages: Homooligomer (via leucine zipper domain and hexapeptide motif) (PubMed:23141066). Isoform a (via leucine zipper domain) forms a heterooligomer with isoform c (via leucine zipper domain) (PubMed:23141066). Isoform c does not self-associate (PubMed:23141066).
messages: Inactive when associated with isoform c. Dissociation from isoform c, which is dependent on the phosphorylation of the C-terminal hexapeptide, results in self-association and activation. Transient increase in Ca(2+) levels caused by axonal injury or synaptic activity triggers the dissociation of isoform a from isoform c; the dissociation may be influenced by the phosphorylation status of the C-terminal hexapeptide.
messages: Overcome the lack of synaptogenesis caused by the loss of rpm-1 ubiquitin ligase activity (PubMed:17698012). Defects in axonal microtubule development (PubMed:19164707, PubMed:23000142). Double knockout with dlk-1 also suppresses the eva-1 receptor expression defect in the madd-3 single knockout (PubMed:27123983). Triple knockout with madd-3 and unc-54 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant (PubMed:27123983).
messages: Phosphorylation at Ser-874 and/or at Ser-878 abolishes interaction with isoform c and promotes binding to isoform a kinase domain (likely in trans) resulting in isoform a self-association and activation.
messages: Produced by alternative polyadenylation. The alternative polyadenylation site is in intron 7. In neurons, the usage of this polyadenylation site is regulated by the antagonist action of sydn-1 and ssup-72.
messages: Synapse
messages: The C-terminal domain is important for localization to synapses and axons.
messages: The C-terminal hexapeptide motif is required for homooligomerization and for its activation.
messages: Ubiquitinated by rpm-1. Negatively regulated by ubiquitination by fsn-1 bound rpm-1, followed by degradation.
messages: axon
messages: cilium
messages: dendrite

6239:CELE F55H2.2
gene id: 6239:CELE_F55H2.2
uniprot id: P34462
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE F25E2.3
gene id: 6239:CELE_F25E2.3
uniprot id: Q19781
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE T08D10.2
gene id: 6239:CELE_T08D10.2
uniprot id: Q22343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
messages: Nucleus

6239:CELE Y59A8B.23
gene id: 6239:CELE_Y59A8B.23
uniprot id: G5EEN4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Expressed at all stages.
messages: Hermaphrodites arrest after the first molt and die after at most 6 days. Most animals appear L2-like with morphologies of gonads and vulva that are out of step with the developmental stage. Mutants have a dilated intestinal lumen with extensive internal folding associated with the accumulation of undigested bacteria and a shortened excretory canal. Some animals have adult-type alae and are sterile with vulva and germ line formation defects (PubMed:20595048). In RNAi-mediated knockdown, impaired survival and slower volume recovery upon hypertonic stress (PubMed:17596296).
messages: Interacts (via C-terminus) with clh-3; required for the phosphorylation-mediated inhibition of clh-3 function (PubMed:15684092). Interacts (via C-terminus) with wnk-1; the interaction is direct (PubMed:17596296, PubMed:18049475).
messages: Nucleus
messages: Phosphorylated at Thr-280 and Ser-419 probably by wnk-1; phosphorylation results in weak activation (PubMed:18049475). Predominantly autophosphorylated at Thr-32 and Ser-190 and weakly autophosphorylated at Thr-13 and Ser-405 in vitro (PubMed:20595048).
messages: Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation-mediated inhibition of the chloride channel clh-3 (PubMed:15684092, PubMed:17596296). In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1 (PubMed:23076791). Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages (PubMed:20595048). In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. By controlling clh-3 activity, may regulate the development of the excretory canals and fertility (PubMed:18049475).
messages: Ubiquitously expressed with a higher expression in the excretory cell. Expressed in both male and female germ cells; up-regulated in maturing spermatocytes but absent in mature sperm.

6239:CELE C39D10.3
gene id: 6239:CELE_C39D10.3
uniprot id: A4UVJ6
uniprot id: Q18524
names: Similarity
messages: Belongs to the cytidylyltransferase family.

6239:CELE C01G5.8
gene id: 6239:CELE_C01G5.8
uniprot id: P90740
uniprot id: V6CK03
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: No visible phenotype in normal conditions. Strong increase of embryonic lethality following cisplatin, nitrogen mustard or mitomycin-C (MMC) treatment.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

6239:CELE C54F6.11
gene id: 6239:CELE_C54F6.11
uniprot id: Q5CCI8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T07A9.9
gene id: 6239:CELE_T07A9.9
uniprot id: O44411
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Expressed from early embryonic stages through to adulthood.
messages: Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size (PubMed:24552710). May regulate fat storage via the insulin/IGF pathway (PubMed:24552710).
messages: RNAi-mediated knockdown results in an extended lifespan, reduced brood size, slower growth rate and increased fat storage.
messages: Ubiquitously expressed.
messages: nucleolus

6239:CELE C54C8.1
gene id: 6239:CELE_C54C8.1
uniprot id: O17706
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F27D9.5
gene id: 6239:CELE_F27D9.5
uniprot id: Q19842
names: Cofactor
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Consists of an N-terminal biotin carboxylation/carboxylase (BC) domain that catalyzes the transient carboxylation of the biotin covalently attached to the C-terminal biotinyl-binding/biotin carboxyl carrier (BCC) domain.
messages: Mitochondrion matrix
messages: The biotin cofactor is covalently attached to the C-terminal biotinyl-binding domain and is required for the catalytic activity.
messages: The holoenzyme is a dodecamer composed of 6 alpha subunits and 6 beta subunits (By similarity). Interacts with sir-2.2 and sir-2.3 (PubMed:23438705).
messages: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).

6239:CELE ZC155.1
gene id: 6239:CELE_ZC155.1
uniprot id: G5EEA8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6239:CELE C30B5.9
gene id: 6239:CELE_C30B5.9
uniprot id: C8JQP7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C14B9.1
gene id: 6239:CELE_C14B9.1
uniprot id: P34328
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE ZK637.3
gene id: 6239:CELE_ZK637.3
uniprot id: P30639
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the TIP family.
messages: Expressed in all somatic gonadal cells including distal tip cells, anchor cell, uterine precursor cells and spermatheca precursor cells of the hermaphrodite. Also expressed in the pharynx, pharyngeal-intestinal valve, intestine, excretory cell and canal, seam cells, a subset of hypodermal cells, vulval precursor cells of the hermaphrodite and hook precursor cells in the male.
messages: Expressed in the somatic gonad from the L3 stage of larval development to adulthood.
messages: Hermaphrodites are maternal effect lethal and have elongated and strained appearing distal tip cells with abnormal migration. Male animals have detached gonadal cells that do not migrate leading to a partially elongated gonad. RNAi-mediated knockdown results in a mild defective gonad phenotype with 11% of animals having detached gonads and 17% of animals having 'stringy' gonads.
messages: Lateral cell membrane
messages: Probable cell adhesion protein involved in gonadal cell migration.

6239:CELE R10H10.2
gene id: 6239:CELE_R10H10.2
uniprot id: Q10579
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: May play a role in the spermatocyte cytoskeleton, possibly interacting with actin.
messages: Testis, in both spermatogonial cells and spermatocytes.
messages: cytoskeleton

6239:CELE F08H9.3
gene id: 6239:CELE_F08H9.3
uniprot id: Q19227
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE Y17G7B.17
gene id: 6239:CELE_Y17G7B.17
uniprot id: Q9XXH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

6239:CELE T21D12.2
gene id: 6239:CELE_T21D12.2
uniprot id: O16787
uniprot id: U4PBE1
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C05G6.1
gene id: 6239:CELE_C05G6.1
uniprot id: Q65CM0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in the intestine.
messages: Ligand-activated transcription factor (By similarity). Involved in modulating serotonin-mediated induction of adipose triglyceride lipase atgl-1, thereby regulating body fat (PubMed:24120942).
messages: Nucleus
messages: RNAi-mediated knockdown abrogates the increase in adipose triglyceride lipase atgl-1 expression seen in serotonin-treated animals.

6239:CELE Y63D3A.5
gene id: 6239:CELE_Y63D3A.5
uniprot id: Q9U1W1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Expressed in intestinal, hypodermal and muscle tissues (PubMed:21478858). Highly expressed in the reproductive system (PubMed:21478858).
messages: Expressed throughout embryogenesis (at protein level) (PubMed:18635357). First expressed at the two-cell stage of embryogenesis (at protein level) (PubMed:18635357).
messages: Hexamer (PubMed:21478858). The N-terminus assembles into an octamer and the C-terminus forms a dimer thus the N-terminus mediates its oligomerization, whereas the C-terminus restricts the full-length protein to form hexamers in solution in vitro (PubMed:21478858). Interacts (via N-terminus) with sec-16A.1; the interaction is direct and is required for both the localization of tfg-1 and to maintain the distribution of sec-16A.1 at endoplasmic reticulum exit sites (ERES) (PubMed:21478858).
messages: In its hexameric form, promotes the accumulation of sec-16A.1 and the COPII subunit npp-20 at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER), to positively regulate secretory cargo trafficking from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi apparatus (PubMed:21478858). Required for the assembly of proteins, such as the GTPase rab-6, at the Golgi apparatus (PubMed:21478858). Plays a role in negatively regulating cell death and promoting cell and body growth (PubMed:18635357).
messages: Mitochondrion
messages: RNAi-mediated knockdown in embryos results in lethality prior to hatching and an increased number of apoptotic cell corpses at the comma stage of embryogenesis (PubMed:18635357). RNAi-mediated knockdown in developing larvae results in smaller adults which have reduced locomotory muscle and epidermal cell sizes, and reduced total body protein content (PubMed:18635357). Cell size defects are suppressed in a ced-4 n1162 or ced-4 RNAi mutant background (PubMed:18635357). RNAi-mediated knockdown results in smaller and poorly stacked endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and Golgi membranes, fragmentation of the endoplasmic reticulum and few Golgi networks (PubMed:21478858). RNAi-mediated knockdown reduces the accumulation of sec-16A.1 and the COPII subunit npp-20 at endoplasmic reticulum exit sites (ERES) within the germline (PubMed:21478858). Does not reduce the expression of sec-16A.1 and does not affect the localization of npp-20 to the nuclear envelope (PubMed:21478858). RNAi-mediated knockdown causes the disassembly of the npp-20-containing heterotetrameric complex, resulting in monomeric npp-20 (PubMed:21478858). RNAi-mediated knockdown results in defective secretory cargo trafficking from the endoplasmic reticulum to the ERGIC and Golgi apparatus, and the subsequence accumulation of secreted integral membrane proteins including snb-1, cav-1 and sqv-8 in the endoplasmic reticulum (PubMed:21478858). RNAi-mediated knockdown results in disrupted retrograde trafficking of the GTPase rab-6 from the Golgi apparatus to the endoplasmic reticulum and causes the accumulation of rab-6 at enlarged early endosomes (PubMed:21478858).

6239:CELE C49C3.1
gene id: 6239:CELE_C49C3.1
uniprot id: Q9XUG5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y48A6B.3
gene id: 6239:CELE_Y48A6B.3
uniprot id: Q9XXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE K10C2.1
gene id: 6239:CELE_K10C2.1
uniprot id: Q94269
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE M176.1
gene id: 6239:CELE_M176.1
uniprot id: Q21550
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE T11G6.1
gene id: 6239:CELE_T11G6.1
uniprot id: P34183
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (Probable). Required for germ cell development (PubMed:21464306).
messages: RNAi-mediated knockdown results in gonadal defects including smaller, narrower gonads and reduced fertility with either no oocytes or no fertilized eggs in the majority of animals (PubMed:21464306). RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress (PubMed:23076791).

6239:CELE Y52D3.1
gene id: 6239:CELE_Y52D3.1
uniprot id: G5ECN5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Ectopic expression of pre-synaptic reporter snb-1-GFP in ASI sensory neurons. Along the dorsal nerve cord of DD motoneurons, pre-synaptic puncta appear diffuse or smaller and synapse localization of sad-1 is disrupted. Germline hyperplasia and loss of aak-2 phosphorylation during dauer development (PubMed:20110331). During neuroblast division, daughter cell size asymmetry in the Q.p division is defective (PubMed:23267054). Animals are slightly stiff but with active locomotion (PubMed:20023164). In par-4 (it33) mutants, causes embryonic lethality (PubMed:20023164). In ced-3 (n3692) mutants, impaired cell shedding during embryogenesis which results in the generation of an ectopic excretory cell (PubMed:22801495). In addition, these double mutants produce additional AVM or PVM mechanosensory neurons (PubMed:23267054).
messages: Expressed in embryo.
messages: Expressed in nervous system, pharynx and excretory canal (PubMed:20023164). Expressed in germline (PubMed:20110331).
messages: Interacts with sad-1 (PubMed:20023164). Interacts with par-4 (PubMed:20110331).
messages: Nucleus
messages: Perikaryon
messages: Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses (PubMed:20023164). Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4 (PubMed:20110331, PubMed:22801495, PubMed:23267054). May be involved in maintaining the integrity of the early embryonic cortex when bound to par-4 (PubMed:20110331).
messages: Synapse
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: axon
messages: cell cortex
messages: dendrite

6239:CELE H27M09.3
gene id: 6239:CELE_H27M09.3
uniprot id: Q9N5K3
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Chromosome
messages: Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC (PubMed:19798442, PubMed:21840865). Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination (PubMed:19798442).
messages: High levels of embryonic lethality and a high percentage of males among the surviving progeny (PubMed:19798442). Failure to localize syp-1 and syp-3, components of the synaptonemal complex central region, to chromosomes (PubMed:19798442). Failure to form chromosome synapses and lack of synaptonemal complex formation leading to a delay in meiotic progression (PubMed:19798442). Impaired stabilization of homologous pairing interactions (PubMed:19798442). Lack of chiasmata formation during diakinesis (PubMed:19798442). Reduced crossover frequency (PubMed:19798442). Increased rad-51 foci during pachytene indicating impaired DNA double-strand break (DSB) repair progression (PubMed:19798442). Elevated germ cell apoptosis (PubMed:19798442). Disruption of plk-2 localization to synapsed chromosomes during pachytene (PubMed:28346135).
messages: Phosphorylated at Ser-269 by plk-1 and plk-2. Phosphorylation starts at the pachytene stage during oogenesis and depends on crossover precursor formation. Phosphorylation negatively regulates meiotic DNA double-strand break (DSB) formation.

6239:CELE R05F9.1
gene id: 6239:CELE_R05F9.1
uniprot id: Q21747
uniprot id: Q21748
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE F58G1.1
gene id: 6239:CELE_F58G1.1
uniprot id: O62275
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline (PubMed:17110334, PubMed:29791857, PubMed:30728462). Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue (PubMed:29791857). Also interacts with the mRNA targets of 22G-RNAs (PubMed:29791857). Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes (PubMed:29791857, PubMed:29769721).
messages: Belongs to the argonaute family. WAGO subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed in the hermaphrodite germline and in oocytes (PubMed:29791857, PubMed:29769721, PubMed:30728462). Expressed at a low level in the male germline (PubMed:29791857). Not expressed in the soma of hermaphrodites or males (PubMed:29791857).
messages: Expressed throughout development (PubMed:29769721, PubMed:29791857, PubMed:30728462). Following fertilization, in the zygotes and early embryos, it is expressed in the germline (PubMed:29791857). Evenly distributed in one-cell stage embryos (PubMed:29791857). In early embryos, segregates to germline precursor cells and is expressed in P1-P4 germline cells (PubMed:29791857, PubMed:29769721, PubMed:30728462). Also expressed in the endomesodermal (EMS) precursor cell (PubMed:29791857). Exclusively expressed in Z2 and Z3 larval cells at hatching (PubMed:29791857).
messages: Interacts with znfx-1; the interaction promotes the transmission of epigenetic information across generations (PubMed:29769721). May interact with mina-1 (PubMed:30728462).
messages: Members of the WAGO (worm-specific argonaute) subfamily lack conserved metal-binding residues found in other argonaute proteins and probably do not cleave target mRNAs directly.
messages: perinuclear region

6239:CELE F54G8.3
gene id: 6239:CELE_F54G8.3
uniprot id: Q03600
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin alpha chain family.
messages: Heterodimer of an alpha and a beta subunit. Alpha ina-1 associates with beta pat-3 (PubMed:9247263). Interacts (via cytoplasmic domain) with src-1 (when phosphorylated at 'Tyr-416') (PubMed:20226672).
messages: Membrane
messages: Plays a role in cell migration, axon fasciculation, and morphogenesis (PubMed:9247263). During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419, PubMed:22732572, PubMed:25982859). Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p (PubMed:25373777). Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).
messages: RNAi-mediated knockdown in distal tip cell (DTC) causes DTC morphological and guidance defects such as precocious dorsal turns, a failure to reach the vulva and a bloated distal gonad (PubMed:19023419). Embryos at the comma, 1.5-fold and 2-fold stages have increased number of cell corpses due to a defect in cell engulfment (PubMed:20226672). RNAi-mediated knockdown with mig-38 results in enhanced gonad DTC migration (PubMed:22732572).
messages: phagocytic cup
messages: phagosome membrane

6239:CELE F14F9.5
gene id: 6239:CELE_F14F9.5
uniprot id: Q9GUC9
names: Subcellular Location Annotation
messages: Secreted

6239:CELE C49A1.2
gene id: 6239:CELE_C49A1.2
uniprot id: A0A131MB99
uniprot id: A0A131MBH1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C34C6.3
gene id: 6239:CELE_C34C6.3
uniprot id: Q18424
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK792.8
gene id: 6239:CELE_ZK792.8
uniprot id: Q9U1N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease required for autophagy (PubMed:22767594, PubMed:30880001). Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.1, but it cleaves lgg-1 precursors less efficiently than atg-4.1 (Probable). In contrast to atg-4.1, plays a more significant role in the later phases of autophagy and in addition has a role in autophagosome maturation (PubMed:30880001). Acts redundantly with atg-4.1 to promote the lgg-1 delipidation to release the protein from membranes, which facilitates multiple events during macroautophagy (PubMed:30880001). Regulates the accumulation of autophagic structures in neurons and is specifically, required for the maturation and elimination of autophagosomes from the synaptic region of AIY interneurons (PubMed:30880001).
messages: Cytoplasm

6239:CELE F58F6.1
gene id: 6239:CELE_F58F6.1
uniprot id: O44174
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y53C12B.5
gene id: 6239:CELE_Y53C12B.5
uniprot id: O18214
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in late larvae of both sexes. In the fourth larval stage, expression is approximately six-fold higher in males than in hermaphrodites. Expressed in ADF chemosensory neurons in males from the L4 larval stage (PubMed:31264582). Expressed in cells of the male tail tip from the L4 larval stage (PubMed:18550714). Not expressed in cells of the hermaphrodite tail tip at any developmental stage (PubMed:18550714).
messages: Expression is undetectable in hermaphrodites, but persists in males (PubMed:9490411). In males, expressed in cells of the tail tip (PubMed:18550714).
messages: Negatively regulated by lin-41 which causes degradation of the mRNA encoding this protein.
messages: Nucleus
messages: Transcription factor which binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer (PubMed:9490411). Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis (PubMed:18550714, PubMed:21408209). Promotes male-specific development of two tissues, the peripheral nervous system and the intestine (PubMed:9490411). In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs (PubMed:9490411). In the intestine, causes repression of vitellogenin gene transcription (PubMed:9490411).

6239:CELE Y46H3C.1
gene id: 6239:CELE_Y46H3C.1
uniprot id: A0A0K3AT19
uniprot id: A0A0K3AVB7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T28H11.8
gene id: 6239:CELE_T28H11.8
uniprot id: Q23063
names: Subcellular Location Annotation
messages: Membrane

6239:CELE D2030.9
gene id: 6239:CELE_D2030.9
uniprot id: C6KRL4
uniprot id: P90794
uniprot id: S6FN32
uniprot id: S6FWQ6
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the WD repeat LEC14B family.
messages: Increased lifespan (PubMed:17411345). RNAi-mediated knockdown significantly prevents Mn(2+)-induced dopaminergic CEP neuron degeneration (PubMed:23721876). RNAi-mediated knockdown increases tatn-1 expression and enzymatic activity (PubMed:31043480).
messages: Involved in regulation of lifespan (PubMed:17411345). Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876). Inhibits the skn-1-mediated up-regulation of tatn-1 (PubMed:31043480).
messages: Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+).

6239:CELE Y63D3A.6
gene id: 6239:CELE_Y63D3A.6
uniprot id: Q9U1W0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T07A5.1
gene id: 6239:CELE_T07A5.1
uniprot id: Q10044
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F47C10.6
gene id: 6239:CELE_F47C10.6
uniprot id: O01558
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y43F4B.3
gene id: 6239:CELE_Y43F4B.3
uniprot id: G5EEU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
messages: Chromosome
messages: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate (PubMed:22939621). Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina (PubMed:22939621). Required for small-RNA-induced H3K9 methylation (PubMed:26365259). Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9 (PubMed:27668659).
messages: Nucleus
messages: Nucleus lamina
messages: The SET domain is not required for localization to nuclear foci.

6239:CELE W10D5.2
gene id: 6239:CELE_W10D5.2
uniprot id: Q94360
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion

6239:CELE ZK682.4
gene id: 6239:CELE_ZK682.4
uniprot id: Q23579
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in intestine, neurons in head, body and tail, and in body hypodermis, and vulva (PubMed:19632181). Expressed in neurons in the male-specific genital sensilla (simple sense organs) known as rays (PubMed:15183729).
messages: Expressed in late embryogenesis, larval stages L2, L3 and L4 and in adults.
messages: Heterodimer with hlh-2.
messages: Nucleus
messages: Probable transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'.

6239:CELE K10G6.3
gene id: 6239:CELE_K10G6.3
uniprot id: A0A0K3AUE4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in seam cells, intestine cells, pharyngeal muscles and nerve ring neurons.
messages: In embryos, expressed in 20- to 30-cell stage and expression decreases after the 200-cell stage (PubMed:23666922). Expressed in seam cells, intestine cells, pharyngeal muscles and nerve ring neurons in L3 stage larvae and expression persists into adults (PubMed:21471153).
messages: Nucleus
messages: RNA-binding protein, which regulates the expression of proteins required to control developmental timing of events during the L2 to L3 larval stage switch (PubMed:21471153). Binds to the 3'UTR of the transcript of the heterochronic protein lin-28 to post-transcriptionally negatively regulate its expression in certain tissue types in the later larval stages (PubMed:21471153). During larval development, controls the timing of seam cell division and terminal differentiation into adult alae (PubMed:21471153). In vitro, it can also bind to DNA through its first zinc finger (PubMed:21471153). May bind directly or indirectly to the promoter of the sex-determining factor xol-1 to activate its transcription (PubMed:23666922). Its activation of xol-1 transcription controls sex determination and X chromosome dosage compensation to promote male development (PubMed:23666922). Through the negative regulation of lin-28 transcript, it also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153). Acts in the intestine to play a role in regulating adult lifespan (PubMed:21471153).
messages: RNAi mediated knockdown at early larval stages and in young adults results in an extended lifespan (PubMed:21471153). RNAi-mediated knockdown results in delayed developmental defects with an increased number of seam cells in young adults (PubMed:21471153). RNAi-mediated knockdown suppresses the embryonic lethality of hermaphrodites in the double fox-1 y303 and sex-1 y263 mutant background (PubMed:23666922).
messages: The Zinc finger domains 1 and 5 bind single-stranded and double-stranded RNAs (PubMed:21471153). The Zinc finger domain 1 binds DNA in vitro (PubMed:21471153).

6239:CELE T07D10.2
gene id: 6239:CELE_T07D10.2
uniprot id: O02300
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Detected in the left ASE gustatory neuron, the chemosensory neuron pairs ASH and ADF, and the PQR tail neuron (PubMed:23112336). In males, detected in hook and tail sensory neurons involved in vulval sensing and hermaphrodite contact, and in spicule protractor muscles (PubMed:23112335).
messages: Receptor for nematocin (PubMed:23112336, PubMed:23112335). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system (PubMed:23112336, PubMed:23112335). The activity of this receptor may be modulated by ntr-2, leading to reduced intracellular cAMP production (PubMed:23112335). Plays a role in gustatory associative learning (PubMed:23112336). Also plays a role in male mating behavior (PubMed:23112335).
messages: Viable and fertile (PubMed:23112336). Gustatory associative learning in response to salt cues is disrupted (PubMed:23112336). Males have reduced reproductive success, due to a range of aberrant mating behaviors (PubMed:23112335). Double knockouts with ntr-2 partially rescue the reproductive phenotypes (PubMed:23112335).

6239:CELE ZK418.3
gene id: 6239:CELE_ZK418.3
uniprot id: Q23481
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T22A3.6
gene id: 6239:CELE_T22A3.6
uniprot id: P91823
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R13H9.2
gene id: 6239:CELE_R13H9.2
uniprot id: Q17856
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C32A3.2
gene id: 6239:CELE_C32A3.2
uniprot id: Q09261
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE ZK973.9
gene id: 6239:CELE_ZK973.9
uniprot id: Q9N4L9
names: Similarity
messages: Belongs to the SS18 family.

6239:CELE Y54E2A.11
gene id: 6239:CELE_Y54E2A.11
uniprot id: Q9XWI6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: Extended lifespan in adults.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

6239:CELE F35E8.9
gene id: 6239:CELE_F35E8.9
uniprot id: O45450
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K06H7.9
gene id: 6239:CELE_K06H7.9
uniprot id: G5EFQ1
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

6239:CELE K08C7.3
gene id: 6239:CELE_K08C7.3
uniprot id: A0A061AD21
uniprot id: A0A061AJI9
uniprot id: C1P640
uniprot id: C1P641
uniprot id: G5EEV6
uniprot id: Q21313
names: Caution
names: Disruption Phenotype
names: Function
messages: During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles.

6239:CELE C23H4.6
gene id: 6239:CELE_C23H4.6
uniprot id: B6VQ85
uniprot id: Q93250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC6 subfamily.
messages: Chromosome
messages: Nucleus

6239:CELE Y105E8A.4
gene id: 6239:CELE_Y105E8A.4
uniprot id: Q9NEZ8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

6239:CELE C17G10.2
gene id: 6239:CELE_C17G10.2
uniprot id: Q09974
names: Similarity
messages: Belongs to the TTC4 family.

6239:CELE K08D12.2
gene id: 6239:CELE_K08D12.2
uniprot id: Q966I6
names: Function
names: Similarity
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.

6239:CELE Y5H2B.1
gene id: 6239:CELE_Y5H2B.1
uniprot id: Q966A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 11 family.
messages: Golgi stack membrane
messages: Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (By similarity). Required for axon regeneration after injury (PubMed:31371405).

6239:CELE K07A1.9
gene id: 6239:CELE_K07A1.9
uniprot id: A0A1N7SYQ3
uniprot id: A0A1N7SYV6
uniprot id: A0A1N7SZF7
uniprot id: P90914
uniprot id: Q8I4H6
names: Function
names: Similarity
messages: Belongs to the R-transferase family.
messages: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.

6239:CELE T15D6.6
gene id: 6239:CELE_T15D6.6
uniprot id: O02316
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE ZC334.1
gene id: 6239:CELE_ZC334.1
uniprot id: Q9XUI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE Y92C3B.2
gene id: 6239:CELE_Y92C3B.2
uniprot id: P90978
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms a heterodimer with the U2AF small subunit.
messages: Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).
messages: Nucleus

6239:CELE F54D1.4
gene id: 6239:CELE_F54D1.4
uniprot id: Q20765
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE E04A4.4
gene id: 6239:CELE_E04A4.4
uniprot id: O44476
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RNase Z family.
messages: Does not regulate the mitochondrial unfolded protein response following mitochondrial stress.
messages: Highly expressed in the germline.
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus
messages: Plays a role in mitochondrial unfolded protein response (PubMed:35451962). Upon mitochondrial stress is exported from the nucleus where its tRNA endonuclease activity is negatively regulated (PubMed:35451962). In response to mitochondrial stress, might be involved in activating a transcriptional response in an ATFS-1- and DVE-1-dependent manner (PubMed:35451962). May play a role in negatively regulating the mitochondrial membrane potential (PubMed:35451962).
messages: RNAi-mediated knockdown attenuates the mitochondrial unfolded protein response as indicated by reduced expression of hsp-6.
messages: Up-regulated in response to mitochondrial stress.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:35451962). Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Involved in germline proliferation (PubMed:14729485). May be required for both mitosis and meiosis in germ cells (PubMed:14729485).

6239:CELE F07F6.5
gene id: 6239:CELE_F07F6.5
uniprot id: Q09304
names: Function
names: Subcellular Location Annotation
messages: Acts downstream of daf-16/foxo to suppress tumors induced by disruption of gld-1. Potentially a direct target of daf-15/foxo.
messages: Membrane

6239:CELE F56H9.4
gene id: 6239:CELE_F56H9.4
uniprot id: Q20910
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the G-alpha family.
messages: Expressed in ASJ neurons.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity). Plays role in innate immunity and maintaining survival in response to metabolites of E.coli (PubMed:21108728). This might be by regulating the expression and signaling of genes such as lys-8, ins-7 and daf-28 (PubMed:21108728). Has a role in lifespan to promote longevity (PubMed:17187771, PubMed:21108728).

6239:CELE Y46E12BL.3
gene id: 6239:CELE_Y46E12BL.3
uniprot id: Q965N7
names: Similarity
messages: Belongs to the SPSB family.

6239:CELE W05H5.6
gene id: 6239:CELE_W05H5.6
uniprot id: O18175
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F08B1.2
gene id: 6239:CELE_F08B1.2
uniprot id: Q19187
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in PHA sensory neurons and in head muscles (PubMed:9096403, PubMed:21124861). Expressed in chemosensory neurons AWC, ASE, ASJ, AUA, PHA and PHB, interneuron PVQ, several other unidentified head neurons, an excretory gland cell and head muscles (PubMed:26434723). Highly expressed in the sensory cila at the nose tip (PubMed:26434723).
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:9096403). Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size (PubMed:21124861, PubMed:26434723).
messages: Increased body size and increased formation of dauer larvae. Double knockout with che-2 rescues the locomotion defect in the single che-2 mutant.
messages: Perikaryon
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium
messages: dendrite

6239:CELE F59E11.11
gene id: 6239:CELE_F59E11.11
uniprot id: O16753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C51E3.7
gene id: 6239:CELE_C51E3.7
uniprot id: G5ECN9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase S8 family. Furin subfamily.
messages: Expressed in head and tail ganglia (PubMed:7954663, PubMed:11717360, PubMed:12657671, PubMed:24671950). Expressed in neurons including mechanosensory and motor neurons, and interneurons (at protein level) (PubMed:11717360, PubMed:12657671). Expressed in the nerve ring, ventral nerve cord and intestine (PubMed:24671950).
messages: Interacts (via C-terminus) with F-box protein fsn-1 (via SPRY domain); the interaction results in egl-3 proteasomal degradation.
messages: Secreted
messages: Serine endoprotease which cleaves preproteins at paired basic amino acids (PubMed:12657671, PubMed:15180830, PubMed:16945111, PubMed:23665919, PubMed:24671950). Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides (PubMed:12657671, PubMed:16945111). Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit (PubMed:23658528). Regulates sensitivity to mechanosensory stimuli (PubMed:11717360). By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions (PubMed:12657671). Probably by processing flp neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271). Cleaves pro-insulin-like proteins ins-3, ins-4 and ins-6 into their mature active forms (PubMed:23665919, PubMed:24671950). Together with convertase kpc-1, cleaves pro-insulin-like protein ins-18 (PubMed:24671950). By controlling ins-4 and ins-6 processing and thus the activation of the daf-2/InsR pathway, negatively modulates synapse development and synaptic transmission at neuromuscular junctions (PubMed:23665919). Similarly, by controlling ins-4 and ins-6 processing, negatively regulates dauer formation under optimal environmental conditions (PubMed:24671950). Under adverse environmental conditions, may promote dauer formation by processing ins-18, a daf-2/InsR antagonist (PubMed:24671950). May cleave dense-core vesicle membrane protein ida-1 (PubMed:15180830). Involved in egg-laying, fat storage and locomotion (PubMed:11813735, PubMed:11717360, PubMed:17564681).
messages: Ubiquitinated.
messages: axon
messages: secretory vesicle lumen

6239:CELE C42D8.5
gene id: 6239:CELE_C42D8.5
uniprot id: Q18581
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the peptidase M2 family.
messages: Expressed in embryos and larvae (PubMed:14559923). Expressed in an oscillating expression pattern during larval development, with low expression at the L2 stage, high expression at the L2/L3 transition and low expression at the L3 stage (PubMed:28933985).
messages: Expressed in the hypodermis, in the vulva during organogenesis, and in the ray papillae of the male tail.
messages: Inactive as a metallopeptidase, due to a lack of active site residues (PubMed:14559923). Required for larval molting, male tail development, and formation of adult alae (PubMed:14559923). Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production (PubMed:28933985). Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events (PubMed:28933985). Might act downstream of the heterochronic protein lin-41 (PubMed:28933985). Negative regulator of lifespan, heat and oxidative stress response and age-related degenerative changes like reduced pharyngeal pumping and decreased body movements (PubMed:26918946). Lifespan restriction is dependent on the forkhead-type transcription factor daf-16 (PubMed:26918946).
messages: RNAi-mediated knockdown results in the extension of mean and maximum lifespan of 21% and 18%, respectively, and increased resistance to oxidative stress caused by paraquat (PubMed:26918946). RNAi-mediated knockdown in a daf-16 mutant background shortens mean and maximum lifespan by 3% and 2%, respectively (PubMed:26918946). RNAi-mediated knockdown in a let-7 mutant background partially suppresses the retarded and supernumerary hypodermal seam cell divisions, retarded alae production and postembryonic lethality (PubMed:28933985). Double RNAi-mediated knockdown with apl-1 in a let-7 mutant phenotype leads to complete suppression of the heterochronic seam cell defects (PubMed:28933985).

6239:CELE Y38C1AA.2
gene id: 6239:CELE_Y38C1AA.2
uniprot id: Q9N425
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-2 and csn-4. May interact with itself.
messages: Cytoplasm
messages: Nucleus

6239:CELE Y18D10A.20
gene id: 6239:CELE_Y18D10A.20
uniprot id: Q9XW16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.
messages: Expressed in the nerve ring during late embryonic stages. In adults, expression is seen in the neurons, vulva and somatic gonad.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

6239:CELE T01H10.2
gene id: 6239:CELE_T01H10.2
uniprot id: Q22080
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F16H6.7
gene id: 6239:CELE_F16H6.7
uniprot id: Q9XV94
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE C15H7.3
gene id: 6239:CELE_C15H7.3
uniprot id: P34337
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

6239:CELE C34D4.15
gene id: 6239:CELE_C34D4.15
uniprot id: M1ZJS7
uniprot id: Q18450
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T06D8.3
gene id: 6239:CELE_T06D8.3
uniprot id: Q22250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

6239:CELE C02B8.4
gene id: 6239:CELE_C02B8.4
uniprot id: Q11094
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as a transcriptional regulator. Involved in postembryonic mesodermal cell fate specification. Activates ceh-24 and egl-15 during mesodermal patterning.
messages: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer. Forms a heterodimer with hlh-2.
messages: Expressed in defecation-associated muscles and neuron-like cells in the head at the L1 stage. In later larvae, expressed in SM cells and their descendants. Not expressed in differentiated body wall or sex muscles.
messages: Nucleus

6239:CELE C47F8.8
gene id: 6239:CELE_C47F8.8
uniprot id: O62116
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y110A7A.1
gene id: 6239:CELE_Y110A7A.1
uniprot id: Q95Y84
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosomal protein which is recruited to mitotic chromosomes by hcp-3 (CENP-A) and hcp-4 (CENP-C) (PubMed:12080088, PubMed:15767665). Involved in chromosome segregation during mitosis, playing a role in chromosome condensation and in maintaining chromosome morphology, rigidity and orientation during mitosis (PubMed:12080088, PubMed:15767665).
messages: Component of the condensin-2 complex.
messages: Nucleus
messages: RNAi-mediated knockdown results in temperature sensitive embryonic lethality with chromosomes displaying segregation defects with increased anaphase bridges and chromosome lagging.
messages: centromere

6239:CELE Y54G2A.17
gene id: 6239:CELE_Y54G2A.17
uniprot id: Q95XX1
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activity is highest with Mn(2+).
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

6239:CELE C17G1.3
gene id: 6239:CELE_C17G1.3
uniprot id: Q0G821
uniprot id: Q93242
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE R13A5.9
gene id: 6239:CELE_R13A5.9
uniprot id: Q95Y88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

6239:CELE C45B2.5
gene id: 6239:CELE_C45B2.5
uniprot id: Q95YD1
names: Similarity
messages: Belongs to the glutamine synthetase family.

6239:CELE C50E10.4
gene id: 6239:CELE_C50E10.4
uniprot id: Q965H3
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Homodimer. Interacts with ubc-9. Binds through its N-terminal region to the N-terminal region of sor-1.
messages: Nucleus
messages: Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA.
messages: Sumoylated by ubc-9. Sumoylation is required for the transcriptional regulation of homeotic genes.
messages: The RNA-binding region is essential for the localization to subnuclear bodies and its function.
messages: The SAM-like domain, although only slightly related to the SAM domain, apparently displays a similar function. It is essential for homodimerization, the interaction with ubc-9, and the formation of subnuclear bodies.
messages: Widely expressed. Weakly expressed in most somatic cells of 50-cell stage embryos. At 200 cell stage, it is strongly expressed. By comma stage, it is expressed in most somatic cells.

6239:CELE F11H8.3
gene id: 6239:CELE_F11H8.3
uniprot id: P18833
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE F37C12.11
gene id: 6239:CELE_F37C12.11
uniprot id: P49197
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Cytoplasm
messages: Rough endoplasmic reticulum
messages: cytosol

6239:CELE K01G5.5
gene id: 6239:CELE_K01G5.5
uniprot id: O17919
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pseudouridine synthase TruB family.
messages: Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
messages: nucleolus

6239:CELE F33E11.1
gene id: 6239:CELE_F33E11.1
uniprot id: O61854
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE ZK856.1
gene id: 6239:CELE_ZK856.1
uniprot id: Q23639
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the cullin family.
messages: Interacts with rbx-1 and rbx-2.
messages: Neddylated; which enhances the ubiquitination activity of SCF-like complex.
messages: Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline.

6239:CELE W05B5.3
gene id: 6239:CELE_W05B5.3
uniprot id: Q9XUK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE T09B9.3
gene id: 6239:CELE_T09B9.3
uniprot id: Q10049
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58E10.3
gene id: 6239:CELE_F58E10.3
uniprot id: Q9XUW5
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE B0024.6
gene id: 6239:CELE_B0024.6
uniprot id: N1NVB7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in both ASEL and ASER neurons throughout late embryonic and early larval stages. In adults, expressed asymmetrically in ASE left (ASEL) sensory neuron.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron (PubMed:19523832).
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE C54D10.3
gene id: 6239:CELE_C54D10.3
uniprot id: Q18827
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK856.10
gene id: 6239:CELE_ZK856.10
uniprot id: Q23645
names: Similarity
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.

6239:CELE Y39A1B.3
gene id: 6239:CELE_Y39A1B.3
uniprot id: Q9U2M1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Associates with meiotic and mitotic chromosomes prior to the onset of dosage compensation and with hermaphrodite X chromosomes after the onset of dosage compensation (at protein level).
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Component of the condensin I complex, which contains the mix-1/SMC2 and smc-4/SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: dpy-26, capg-1 and dpy-28 (PubMed:19781752, PubMed:19119011, PubMed:18198337). Within the complex, interacts with dpy-26 and smc-4 (PubMed:19781752, PubMed:19119011, PubMed:28301465). Component of the dosage compensation complex, which consist of the condensin I like components mix-1/SMC2 and dpy-27/SMC4, and the three non SMC subunits dpy-26, capg-1 and dpy-28 (PubMed:18198337, PubMed:19781752, PubMed:19119011, PubMed:15557118). Within the complex, interacts with mix-1, dpy-27, dpy-26 and capg-1 (PubMed:15557118, PubMed:18198337, PubMed:19119011, PubMed:28301465). Interacts with smcl-1 (PubMed:28301465).
messages: Expressed in somatic and germline tissues (at protein level).
messages: Nucleus
messages: Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners (PubMed:19119011, PubMed:19781752, PubMed:3779843, PubMed:18198337). Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:19781752, PubMed:19119011). The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex function is required for proper chromosome segregation in mitosis and meiosis (PubMed:19119011). As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, possibly by influencing higher-order chromosome structure (PubMed:18198337, PubMed:19781752). Plays a role in robust cytokinesis upon presence of chromatin obstructions (PubMed:23684975). Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase, possibly through chromatin reorganization (PubMed:3779843, PubMed:19119011, PubMed:15557118).
messages: Results in high larval lethality in hermaphrodites, and survivors exhibit a XX-specific shorter and stouter body morphology (PubMed:18198337). Higher percentage of spontaneous males through X chromosome non-disjunction (PubMed:18198337). Increased number of crossovers, redistribution of crossovers and a reduction in crossover interference in meiosis (PubMed:18198337). Increased number of rad-51 foci in early to mid-pachytene indicating double strand break formation (PubMed:18198337, PubMed:19781752). Increase in X chromosome axis length indicating aberrant chromosome structure (PubMed:19781752). RNAi-mediated knockdown results in chromosome segregation defects in mitosis (PubMed:19119011).
messages: Sumoylated. Sumoylated in the context of the dosage compensation complex but not in the condensin I complex. Sumoylation is important for assembly of the dosage compensation complex and its robust binding to the X chromosome.

6239:CELE C27A7.3
gene id: 6239:CELE_C27A7.3
uniprot id: P90755
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Membrane
messages: Probable phosphodiesterase.

6239:CELE Y54H5A.1
gene id: 6239:CELE_Y54H5A.1
uniprot id: Q9N393
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C38C10.2
gene id: 6239:CELE_C38C10.2
uniprot id: Q03567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

6239:CELE T10C6.5
gene id: 6239:CELE_T10C6.5
uniprot id: O45766
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC15 family.
messages: Component of a spliceosomal complex that is required for activating pre-mRNA splicing.
messages: Component of spliceosomal complex.
messages: Nucleus

6239:CELE F39F10.3
gene id: 6239:CELE_F39F10.3
uniprot id: Q20192
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F58A6.11
gene id: 6239:CELE_F58A6.11
uniprot id: Q20963
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein srb family.
messages: Cell membrane
messages: Expressed in the head sensory neurons ASI, ASK and AWB (PubMed:28662030). Not expressed in male somatic gonads or sperm (PubMed:28662030).
messages: Expressed throughout larval development and adulthood.
messages: G-protein coupled receptor that antagonizes the negative effects of the gcy-35 oxygen sensor on spermatogenesis (PubMed:28662030). This leads to the maintenance of mitochondrial function in developing spermatocytes and/or spermatids prior to testis maturation during the early larval stages (PubMed:28662030). Regulates the navigational capacity of sperm during hyperoxic conditions ensuring the proper targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites (PubMed:28662030). May act in the same signaling pathway as the neuropeptide flp-21 (PubMed:28662030).
messages: Perikaryon
messages: Reduced brood size, which is in part due to an abnormal distribution of male-derived sperm in the hermaphrodite uterus following mating, with sperm reversing course frequently and accumulating at the spermathecal-uterine valve 1 hour following mating (PubMed:28662030). No visible defects in oogenesis (PubMed:28662030). Double knockout with the mcu-1 ju1154 mutant suppresses the sperm navigation defect in the srb-13 single mutant (PubMed:28662030).
messages: dendrite

6239:CELE F02D10.1
gene id: 6239:CELE_F02D10.1
uniprot id: Q19111
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C56C10.1
gene id: 6239:CELE_C56C10.1
uniprot id: Q18891
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Broadly expressed in somatic tissues including the pharynx, intestine, spermatheca, and in coelomocytes (PubMed:27558849). Expressed in the lining of the gut lumen (PubMed:25273556).
messages: Early endosome
messages: Hermaphrodites exhibit sperm-specific sterility and only lay unfertilized eggs (PubMed:27558849). In contrast to wild-type animals, mutant males produce no or few spermatids in their gonads, but instead their gonads accumulate terminally arrested spermatocytes that do not bud and contain four haploid nuclei (PubMed:27558849). In some instances, the spermatocytes have small buds that do not form spermatids (PubMed:27558849). Oocytes and unfertilized eggs contain some larger endocytic structures tethered to yolk granules (PubMed:27558849). RNAi-mediated knockdown results in defective yolk uptake in oocytes with the appearance of endocytic structures containing yolk tethered to large membranous organelles which could be lysosomes (PubMed:25273556). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen which is possibly indicative of increased endosomal fusion activity, and defective trafficking of proteins such as lmp-1 to lysosomal compartments (PubMed:25273556). RNAi-mediated knockdown in a sand-1 mutant background results in defective endosome fusion with the formation of larger, irregularly-shaped rab-5 positive endosomes in oocytes and intestinal cells, and larger yolk-containing granules than in the sand-1 single mutant (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 results in defective protein trafficking to lysosomal compartments, and an irregular distribution of vesicles of various sizes throughout the gut cells (PubMed:25273556). Double RNAi-mediated knockdown together with vsp-33.1 in a sand-1 mutant background rescues the large endosome phenotype and the defective protein trafficking to lysosomal compartments in the sand-1 single mutant, but results in lethality (PubMed:25273556).
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes (PubMed:25273556). Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25273556). Most likely within the CORVET complex, it is involved in the fusion of endocytic compartments (PubMed:25273556). Required for sperm development and function (PubMed:19109425, PubMed:27558849).
messages: Probable core component of the class C core vacuole/endosome tethering (CORVET) complex. The common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, and which further associates with vps-8 and vps-33.2 (PubMed:25273556). Interacts with spe-39 (PubMed:19109425).
messages: Recycling endosome
messages: clathrin-coated vesicle

6239:CELE ZK673.3
gene id: 6239:CELE_ZK673.3
uniprot id: Q09377
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed from the early one-cell or late two-cell stage and continues throughout embryonic and larval development and in adulthood.
messages: Greatly reduced nuclear accumulation of lin-15a protein but no effect on mRNA levels.
messages: Nucleus
messages: Required for translation, stability and/or localization of lin-15a.
messages: Widely expressed throughout embryonic development. Expressed in the six multipotent ventral ectodermal blast cells, P3.p-P8.p, which generate the vulva and in their descendants throughout vulval development.

6239:CELE Y116A8C.28
gene id: 6239:CELE_Y116A8C.28
uniprot id: A0A0K3ARK9
uniprot id: D3NQA9
uniprot id: Q2YS41
uniprot id: Q8I102
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

6239:CELE Y5H2B.5
gene id: 6239:CELE_Y5H2B.5
uniprot id: Q9N4Q5
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C47B2.6
gene id: 6239:CELE_C47B2.6
uniprot id: Q564Q1
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important for the synthesis of glycoproteins and glycolipids.
messages: Expressed in embryos, larvae and adults.
messages: Expressed in gonads, vulva, intestine, hypdermis and nervous system.

6239:CELE T02C12.3
gene id: 6239:CELE_T02C12.3
uniprot id: Q22093
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T26E4.12
gene id: 6239:CELE_T26E4.12
uniprot id: O45838
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE ZK370.7
gene id: 6239:CELE_ZK370.7
uniprot id: Q02334
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Cytoplasmic granule membrane
messages: Membrane

6239:CELE T21C9.4
gene id: 6239:CELE_T21C9.4
uniprot id: Q22640
names: Function
names: Similarity
names: Subunit
messages: Belongs to the E(R) family.
messages: Homodimer.
messages: May have a role in the cell cycle.

6239:CELE M04C9.3
gene id: 6239:CELE_M04C9.3
uniprot id: B3WFY7
uniprot id: P90933
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE W01A11.3
gene id: 6239:CELE_W01A11.3
uniprot id: Q23064
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cargo-specific adapter that is involved in nuclear migration during development and thereafter (PubMed:11748140, PubMed:19605495, PubMed:20005871, PubMed:20921138, PubMed:27697906). Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules (PubMed:11748140, PubMed:16481402, PubMed:25023515). Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations (PubMed:19605495, PubMed:20921138). Moreover, within the complex, also recruits the large microtubule-associated bicd-1-dlc-1-egal-1 and lis-1-nud-2 complexes to the nuclear envelope to regulate both the bidirectional migration of nuclei and the extent of nuclear migrations (PubMed:20005871). Not required for centrosome attachment to the nucleus (PubMed:11748140).
messages: Component of the unc-83-unc-84 LINC complex which contains at least unc-83 and unc-84 (PubMed:11748140, PubMed:16481402). Within the unc-83-unc-84 LINC complex interacts with unc-84 (via C-terminus); the interaction is probably required to recruit unc-83 to the nuclear envelope where it then recruits dynein and kinesin-1 complexes to regulate nuclear migration (PubMed:11748140, PubMed:16481402). Interacts with bicd-1 and dlc-1 (PubMed:20005871). Interacts with nud-2 (via C-terminus); the interaction is direct, and is required for recruitment of nud-2 to the nuclear envelope (PubMed:20005871). Interacts with klc-2; the interaction is direct (PubMed:19605495).
messages: Expressed in embryos and adults (PubMed:11748140). First expressed at the nuclear envelope of migrating hyp7 nuclei, then, at the bean embryonic stage, it is expressed in hyp7 cells, P cells and intestinal cells (PubMed:11748140).
messages: Nucleus membrane
messages: Nucleus outer membrane
messages: Predominantly expressed in migratory nuclei (PubMed:11748140). Expressed in a variety of cell-types, including cells around the pharynx and in the uterus (PubMed:11748140).
messages: The KASH domain, which contains a transmembrane domain, mediates nuclear envelope targeting.
messages: Viable, but with failed nuclear migrations in hyp7 hypodermal precursor cells (PubMed:11748140, PubMed:16481402, PubMed:19605495, PubMed:20005871, PubMed:20921138). Hyp7 nuclei are mislocalized to the dorsal cord of L1 stage larvae (PubMed:19605495).

6239:CELE F26A3.2
gene id: 6239:CELE_F26A3.2
uniprot id: Q93594
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp-1 and ncbp-2 that interacts with m7GpppG-capped RNA.
messages: Lethality in 98.7% of embryos.
messages: Nucleus

6239:CELE M04C9.2
gene id: 6239:CELE_M04C9.2
uniprot id: P90931
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE Y39B6A.34
gene id: 6239:CELE_Y39B6A.34
uniprot id: J7SA57
uniprot id: Q8MYM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain.
messages: Mitochondrion inner membrane

6239:CELE T09A12.3
gene id: 6239:CELE_T09A12.3
uniprot id: A0A0K3AS26
uniprot id: O61220
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK265.5
gene id: 6239:CELE_ZK265.5
uniprot id: Q94403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F08A8.5
gene id: 6239:CELE_F08A8.5
uniprot id: A5Z2X3
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 11 family.
messages: Expressed throughout development and in adult.
messages: Expression is restricted to pharyngeal neurons and gland cells.
messages: Golgi stack membrane
messages: May form oligomers.
messages: N-glycosylated.
messages: Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->3)-GalNAc-alpha-R, Gal-beta-(1->3)-(GlcNAc-beta-(1->6))-GalNAc-alpha-R and Gal-beta-(1->3)-GalNAc acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc in vitro.

6239:CELE B0334.6
gene id: 6239:CELE_B0334.6
uniprot id: Q17478
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE Y50D7A.10
gene id: 6239:CELE_Y50D7A.10
uniprot id: Q8IAA5
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

6239:CELE T06H11.1
gene id: 6239:CELE_T06H11.1
uniprot id: Q22271
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Has a role in mobility, possibly in the transport of potassium in muscles.
messages: Membrane
messages: Worms exhibit defects in mobility. Mutation causes a dumpy (dpy) phenotype thought to be due to hyper-activation of body-wall muscle. Severe mutations cause paralysis thought to be a result of fully contracted muscles.

6239:CELE T17H7.4
gene id: 6239:CELE_T17H7.4
uniprot id: Q95QA6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Basal cell membrane
messages: Cell membrane
messages: Cytoplasm
messages: Embryonic lethal with failed embryonic morphogenesis. Disrupted intracellular structural integrity from the 2-fold stage of embryogenesis resulting in thickening of the epidermis, abnormal intermediate filament distribution and detachment and collapse of muscle from the cell body, particularly in the head, tail and midbody. RNAi-mediated knockdown results in developmental defects whereby 95% embryos do not undergo morphogenesis and arrest before the two-fold stage with abnormal head and tail structures and reduced motility within the eggshell. Lethality in 40% of mutants (that survive RNAi-mediated knockdown) by the adult molting phase of development, with the remaining mutants displaying molting defects and paralysis.
messages: Interacts with vab-10 (via plankin domain).
messages: Isoform a: Expressed in dorso-ventral epidermal cells from the comma stage of embryonic development to adulthood. Isoform j: Expressed in the pharynx and head neurons from the 3-fold stage of embryonic development to adulthood. Isoform k: Expressed in dorso-ventral epidermal cells, the uterus, the vulva, the rectum and in head and tail neurons from the 3-fold stage of embryonic development to adulthood. Specifically expressed in seam cells at the 3-fold stage.
messages: Isoform a: Expressed in the uterus, the vulva, the rectum, mechanosensory neurons and in head and tail neurons. Isoform e: Expressed in spermatheca and weakly in the vulva. Isoform f: Expressed in spermatheca and weakly in the vulva. Isoform i: Expressed in spermatheca and weakly in the vulva.
messages: Required for embryonic morphology and development. Plays both a functional and a structural role in the maintenance and probably biogenesis of fibrous organelles, a hemidesomosome-like junction structure, which ensures muscle stability and muscle connection to the external cuticle.
messages: cytoskeleton
messages: hemidesmosome

6239:CELE F32D8.1
gene id: 6239:CELE_F32D8.1
uniprot id: Q19962
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F27E5.4
gene id: 6239:CELE_F27E5.4
uniprot id: Q09553
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: All developmental stages, but not dauer larva.
messages: Cell membrane
messages: Pharynx muscle cells from its early formation, in the two-fold embryo, until the adult stage.
messages: Role in pharynx function or development.

6239:CELE W02B12.3
gene id: 6239:CELE_W02B12.3
uniprot id: Q23121
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus
messages: Plays a functionally redundant role in spermatogenesis and growth rate control.
messages: RNA-mediated interference (RNAi) of rsp-1 and rsp-2 result in reduced brood sizes and abnormal egg-laying behavior, and the presence of unusual vacuolated structures in some of the secondary spermatocytes, spermatids and spermatozoa.

6239:CELE H06O01.2
gene id: 6239:CELE_H06O01.2
uniprot id: O17909
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y67D2.6
gene id: 6239:CELE_Y67D2.6
uniprot id: Q9BKQ8
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

6239:CELE Y23H5A.3
gene id: 6239:CELE_Y23H5A.3
uniprot id: O76616
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Within the pid-1 variant of the PETISCO complex may stabilize 21U-RNA precursor molecules (PubMed:31147388). Promotes the biogenesis of 21U-RNAs (PubMed:31216475). Required for chromosome segregation and cell division in early embryos (PubMed:31216475).
messages: Component of the pid-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least pid-1, tofu-6, ife-3, pid-3, and erh-2, which is required for the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the complex interacts with pid-1; the interaction is direct (PubMed:31216475, PubMed:31147388). Component of the tost-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least tost-1, tofu-6, ife-3, pid-3, and erh-2, which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the complex interacts with tost-1 (PubMed:31216475). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts with tofu-6 (via the RRM domain) and erh-2 (PubMed:31216475, PubMed:31147388). In contrast to the pid-1 variant of the PETISCO complex, the tost-1 variant of the PETISCO complex plays a minor role in the biogenesis of 21U-RNAs (PubMed:31147388).
messages: Cytoplasm
messages: Expressed from early embryogenesis (at protein level) (PubMed:31147388). During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos (PubMed:31216475).
messages: Expressed in the germline (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown results in chromosome segregation and cell division defects in early embryos (PubMed:31216475). RNAi-mediated knockdown results in defective activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388). RNAi-mediated knockdown disrupts the localization of tofu-6 and erh-2 to the perinuclear region of the germline (PubMed:31216475). Instead erh-2 accumulates in the nucleus (PubMed:31216475). RNAi-mediated knockdown results in decreased expression of tost-1 in the germline and in embryos (PubMed:31216475).
messages: perinuclear region

6239:CELE T10B9.5
gene id: 6239:CELE_T10B9.5
uniprot id: Q27517
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE F55D10.1
gene id: 6239:CELE_F55D10.1
uniprot id: Q20829
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

6239:CELE Y38F1A.10
gene id: 6239:CELE_Y38F1A.10
uniprot id: G5EGQ3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: Expressed ubiquitously in early embryo. At the comma stage and at later embryonic stages expression is mainly restricted to the anterior region of the embryo and to the ventral cord. At the 1.5-fold embryonic stage, expression starts in pharynx and in several head and tail neurons and is maintained in adults. During L1 larval stage, expressed in ALM and PLM neurons and later in PVD and AVM neurons.
messages: Interacts with mlk-1; the interaction is independent of max-2 and mlk-1 kinase activities. Interacts with mig-2 (GTP-bound form).
messages: Isoforms a and c: Partial sensitivity to the heavy metal Cu(2+), which is characterized by a failure of larvae to reach adulthood. Partial reduction in basal kgb-1 phosphorylation and after Cu(2+) treatment (PubMed:20008556). Several DD and DC motoneuron axons fail to reach the dorsal cord. RNAi-mediated knockdown causes a similar phenotype but less severe. In max-2 and pak-1 double mutants, defect in axonal guidance is more severe. Animals are also uncoordinated, defective in egg laying and in distal tip cell (DTC) migration, morphology and guidance, and exhibit ventral enclosure defects (PubMed:17050621). A more severe phenotype has been reported where double mutant animals have embryonic morphogenesis defects resulting in lethality. The few surviving adults are sterile and often have truncated gonads which, in some cases, lack sperm. RNAi-mediated knockdown rescues embryonic lethality of pak-1 and pak-2 double mutants (PubMed:23390595).
messages: Perikaryon
messages: Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk-1/mek-1/kgb-1 pathway (PubMed:20008556). In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc-6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons (PubMed:18499456). Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstream of Rho GTPases (PubMed:17050621, PubMed:19023419, PubMed:23390595). In association with pak-2, plays a role in embryogenesis. In association with pak-1, may be involved in spermatogenesis (PubMed:23390595).
messages: dendrite

6239:CELE K08A8.1
gene id: 6239:CELE_K08A8.1
uniprot id: Q21307
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
messages: Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:18809575, PubMed:20008556). May also have a synergistic role with sek-1 in phosphorylating pmk-1 (PubMed:15256594, PubMed:18809575). Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation (PubMed:11013217, PubMed:15116070, PubMed:18832074, PubMed:18809575). In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses (PubMed:16729024). Involved in resistance to pathogenic bacteria infection (PubMed:15256594). Involved in axon regeneration after injury (PubMed:21670305).
messages: Expressed at the embryonic stage.
messages: Expressed in pharyngeal muscles, uterine endothelial cells, intestine and in neurons of ring ganglia, ventral ganglion and ganglia around anus (PubMed:11013217, PubMed:18809575). Expressed also in hypodermis and body muscles (PubMed:18809575).
messages: Interacts with shc-1; the interaction is independent of mek-1 catalytic activity, is constitutive and may facilitate mlk-1-mediated phosphorylation by bringing mlk-1 and mek-1 together.
messages: Loss of kgb-1 activation (PubMed:15116070, PubMed:20008556). Hypersensitivity to high concentrations of copper (> 50 microM) and cadmium (>5 microM) and to food starvation which is characterized by a failure for most animals to reach adulthood. The few surviving adults appear starved and are defective in egg laying and are infertile (PubMed:11013217, PubMed:15116070). In addition, have moderate susceptibility to pathogenic bacteria infection characterized by a shorter lifespan and a substantial decrease in pmk-1 phosphorylation (PubMed:15256594). In absence of stress, animals have no obvious phenotype (PubMed:11013217, PubMed:15116070).
messages: May be activated by phosphorylation at Ser-221 and Ser-225.
messages: May be phosphorylated at Ser-221 and/or Ser-225 by mlk-1.

6239:CELE K12F2.1
gene id: 6239:CELE_K12F2.1
uniprot id: P12844
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Essential for muscle contraction (PubMed:2583106). Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells (PubMed:17326220).
messages: Expressed in body wall muscles, neighboring vulval muscle cells and the contractile sheath covering the hermaphrodite gonad (myoepithelial sheath cells).
messages: Expression at early and late larval stages is 1:20 of unc-54 (mhc b), however later at L1 and L4 expression is more equal at 1:1.7 and 1:3.1 respectively.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: There are four different myosin heavy chains in C.elegans.
messages: Worms exhibit retarded embryonic development and paralysis (PubMed:2583106). Muscle organization shows disruption with abnormalities of both the filament lattice that constitutes the A-band and the hypodermal cell (PubMed:2583106). RNAi-mediated knockdown causes an accumulation in the proximal gonad of endomitotic mature oocytes in 51 percent of animals (PubMed:17326220).
messages: myofibril

6239:CELE Y2H9A.3
gene id: 6239:CELE_Y2H9A.3
uniprot id: Q9U2P5
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F41G3.17
gene id: 6239:CELE_F41G3.17
uniprot id: Q7JP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE C49H3.11
gene id: 6239:CELE_C49H3.11
uniprot id: P51403
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.

6239:CELE F47A4.3
gene id: 6239:CELE_F47A4.3
uniprot id: Q20498
names: Developmental Stage
names: Function
names: Tissue Specificity
messages: Expressed in all life stages with high expression in L1-L4 larvae stages.
messages: Expressed in coelomocytes, excretory cells, uterine-seam cells and GLR cells.
messages: Functions as a GTPase-activating protein (GAP) for ced-10/rac-1 and CDC42.

6239:CELE Y113G7A.11
gene id: 6239:CELE_Y113G7A.11
uniprot id: Q9U2Z2
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sulfotransferase 1 family.
messages: Expressed in ASJ amphid sensory neurons.
messages: Expressed throughout development, but higher expression in both embryo and adult stages (at protein level) (PubMed:16567400). Expression increases at the dauer larval stage, compared to the level in the embryo (PubMed:16567400).
messages: Membrane
messages: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of xenobiotics that contain phenol functional groups (PubMed:16567400, PubMed:16973616). Acts in ASJ sensory neurons to modulate developmental arrest, perhaps by modifying endocrine signaling via the orphan nuclear receptor nhr-1 (PubMed:30514845).
messages: cytosol

6239:CELE Y52D5A.2
gene id: 6239:CELE_Y52D5A.2
uniprot id: Q9N4S6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F43H9.4
gene id: 6239:CELE_F43H9.4
uniprot id: Q95ZT6
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

6239:CELE K11G9.3
gene id: 6239:CELE_K11G9.3
uniprot id: Q23008
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE F53B3.2
gene id: 6239:CELE_F53B3.2
uniprot id: Q20710
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6239:CELE F56B6.5
gene id: 6239:CELE_F56B6.5
uniprot id: Q22995
uniprot id: Q2V4S5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE B0464.8
gene id: 6239:CELE_B0464.8
uniprot id: Q9XVX8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y6D11A.2
gene id: 6239:CELE_Y6D11A.2
uniprot id: Q8WTM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
messages: cytoskeleton

6239:CELE K10D3.1
gene id: 6239:CELE_K10D3.1
uniprot id: Q21415
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Abolishes signal transduction during cold signaling in intestine and ASER neuron.
messages: Activated by low temperature of 18 degrees Celsius in ASER neuron.
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: During embryogenesis, expressed just before hatching at low levels.
messages: Expressed in the intestine and in the ASER neuron (PubMed:31474366). Also expressed in the thermosensitive RIA interneuron (PubMed:11222641).
messages: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor in the ASER neuron where it triggers a calcium response to activate cold avoidance behavior in response to temperatures below 19 degrees Celsius (PubMed:31474366). Possibly functions as a metabotropic cold receptor and acts upstream of the G(o) G protein goa-1 in the ASER neuron (PubMed:31474366). Also functions in cold sensing in the intestine (PubMed:31474366).
messages: Ionotropic glutamate receptor (By similarity). Activation by glutamate requires additional verification (PubMed:31474366). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity).
messages: Postsynaptic cell membrane

6239:CELE C32E12.5
gene id: 6239:CELE_C32E12.5
uniprot id: Q8T3B9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Embryonic lethal whereby embryos arrest at the three-fold stage of embryogenesis. Embryos initially develop normally until the late comma stage where a delay in the elongation process culminates in severe morphological defects. RNAi-mediated knockdown results in 98% egg-laying defective mutants with muscles lacking the egg-laying muscle specific protein egl-15. In addition, mutants also exhibit a multiple vulvae phenotype with animals having two or three vulvae. Double knockdown with let-381, sys-1, hlh-1 or fozi-1 results in no sex myoblast production.
messages: First expressed in blastomeres in early gastrulating embryos (PubMed:21307099, PubMed:26153233). Expression continues throughout embryonic development with expression in neuronal and non-neuronal progenitors (PubMed:21307099, PubMed:26153233). During larval development, it is expressed in cells including vulval, hypodermal and intestinal cells, and is only expressed in RMH motor neurons (PubMed:21307099, PubMed:26153233). First expressed in the progenitor sex myoblasts at the 16-M cell stage of mesoderm development in hermaphrodite larvae and thereafter in descendants (PubMed:21307099).
messages: Nucleus
messages: Probable transcription factor required for embryogenesis, vulval development and cell fate specification of the postembryonic mesoderm (also known as the M lineage) (PubMed:21307099). Specifically, required for the specification of sex myoblast cells and their development into the muscles that are necessary for egg-laying (PubMed:21307099). In addition, may be involved in RME GABAergic motor neuron progenitor cell fate specification (PubMed:26153233).

6239:CELE Y54E10A.15
gene id: 6239:CELE_Y54E10A.15
uniprot id: Q86S68
names: Similarity
messages: Belongs to the Cdt1 family.

6239:CELE Y39G10AR.18
gene id: 6239:CELE_Y39G10AR.18
uniprot id: Q6AW06
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Chromosome
messages: Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes (PubMed:23806335). Involved in controlling tissue-specific gene expression, particularly in the epidermis (PubMed:31088904).
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Interacts with zfp-1 (via C-terminus) to form a heterodimer known as the zfp-1-dot-1.1 complex or DotCom complex.
messages: Nucleus
messages: RNAi-mediated knockdown results in the ectopic expression of the neuronal identity-inducing transcription factor che-1 in the epidermis.

6239:CELE C52E4.2
gene id: 6239:CELE_C52E4.2
uniprot id: D6R8W7
names: Similarity
messages: Belongs to the MIF family.

6239:CELE ZK1248.11
gene id: 6239:CELE_ZK1248.11
uniprot id: Q23420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

6239:CELE Y69E1A.4
gene id: 6239:CELE_Y69E1A.4
uniprot id: Q9XW33
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE C07A9.7
gene id: 6239:CELE_C07A9.7
uniprot id: P34318
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.

6239:CELE K09G1.1
gene id: 6239:CELE_K09G1.1
uniprot id: D9N146
uniprot id: D9N147
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C18H9.5
gene id: 6239:CELE_C18H9.5
uniprot id: Q09484
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T21F2.1
gene id: 6239:CELE_T21F2.1
uniprot id: H2KYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE M153.2
gene id: 6239:CELE_M153.2
uniprot id: Q21545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE C02F5.9
gene id: 6239:CELE_C02F5.9
uniprot id: P34286
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

6239:CELE F26E4.10
gene id: 6239:CELE_F26E4.10
uniprot id: O01326
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family.
messages: Each RNase III domain binds at least one Mg(2+) or Mn(2+) ion.
messages: Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.
messages: Nucleus
messages: Sterility.

6239:CELE K11G9.4
gene id: 6239:CELE_K11G9.4
uniprot id: G5EFY4
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the INSM1 family.
messages: Expressed in neuronal cells, initially in embryos after gastrulation, including ventral cord motor neurons during the L1 larval stage, FLP, AVM and HSB neurons during L2, and PVM neurons during L3 (PubMed:11274062, PubMed:12954713). Expressed in the BAG neurons at the L2 and L3 stages of larval development (PubMed:25395666). Expressed in the HOB neuron beginning at the larval L4 stage and continuing throughout adulthood (PubMed:12954713). Expressed in the Q neuroblast lineage during larval development (PubMed:23946438, PubMed:11274062).
messages: Expressed in touch cells, HSN cells, ventral cord motor neurons and ciliated ray neurons.
messages: Interacts (via C-terminus) with egl-44 (via N-terminus); the interaction is direct; the interaction may regulate transcription.
messages: Nucleus
messages: Transcription factor (PubMed:30291162). Represses expression of genes involved in differentiation of touch receptor neurons (TRN), probably acting as a heterodimer with egl-44, perhaps by occupying similar cis-regulatory elements as an unc-86/mec-3 heterodimer (PubMed:30291162). Plays a role in cell fate specification of neurons, including the hook neuron HOB, the gas-sensing neuron BAG and touch receptor neurons (PubMed:12954713, PubMed:25395666, PubMed:30291162). Plays a role in neuron differentiation by repressing the expression of zag-1 in FLP neurons, probably acting as a heterodimer with egl-44; because zag-1 represses expression of egl-46 and egl-44, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162). Acts downstream of egl-44 to prevent touch cell differentiation in FLP neurons (PubMed:11274062). Involved in male mating behavior, acting in concert with egl-44, via modulation of expression of polycystins lov-1 and pkd-2, homeodomain protein ceh-26, and neuropeptide-like protein nlp-8 (PubMed:12954713). Modulates the expression of a subset of terminal differentiation genes involved in O(2)- and CO(2)-sensing, acting in parallel to ets-5 and egl-13 (PubMed:25395666). May act upstream of RFX transcription factor daf-19 to regulate gene expression specifically in the HOB neuron (PubMed:20923979). Plays a role in specifying commissural dendrites of the PVD nociceptive neurons, acting in concert with egl-44 (PubMed:29031632). In association with egl-44, regulates cell cycle exit in the neuronal Q cell lineage (PubMed:23946438).

6239:CELE T25B6.2
gene id: 6239:CELE_T25B6.2
uniprot id: Q22763
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE K01G5.7
gene id: 6239:CELE_K01G5.7
uniprot id: O17921
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE C46C2.1
gene id: 6239:CELE_C46C2.1
uniprot id: X5M5N0
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
messages: Expressed in pharynx, nervous system, hypodermis, spermatheca, excretory cell and canal and body wall muscles.
messages: Interacts with gck-3 (via C-terminus).
messages: RNAi-mediated knockdown causes impaired survival and slower volume recovery upon hypertonic stress.
messages: Serine/threonine-protein kinase which phosphorylates gck-3 (PubMed:18049475). Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3 (PubMed:23076791). Essential for larval development and the tubular formation of the excretory canals (PubMed:18049475).
messages: Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.

6239:CELE Y41D4B.13
gene id: 6239:CELE_Y41D4B.13
uniprot id: Q9NHC3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRK family.
messages: Dead cells/corpses fail to be engulfed. Defective in the migration of distal tip cells and gonad development. Actin halos are absent.
messages: Interacts with ced-5 (via C-terminus which contains a candidate SH3-binding, proline-rich region) (PubMed:10707082, PubMed:11703940, PubMed:21616056). Forms a ternary complex with ced-5 and ced-12 (PubMed:11703940). Interacts (via SH2 domain) with src-1 (when activated and phosphorylated at 'Tyr-416') (PubMed:20226672).
messages: Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis (PubMed:10707082, PubMed:6857247, PubMed:1936965, PubMed:11449278, PubMed:15744306, PubMed:19402756, PubMed:20226672). Has a role in the migration of the 2 gonadal distal tip cells (DTCs) (PubMed:10707082). Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382).

6239:CELE F01D4.4
gene id: 6239:CELE_F01D4.4
uniprot id: O17754
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: During FMRFamide-like peptide (FaRPs or FLP) and neuropeptide-like protein (NLP) precursor processing, catalyzes the removal of Arg or Lys residues from the C-terminus following the initial endoprotease cleavage (PubMed:17564681, PubMed:12657671). By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions (PubMed:12657671, PubMed:22275875). Involved in egg-laying, defecation and locomotion (PubMed:11813735, PubMed:17564681, PubMed:22275875). By processing FLP neuropeptides, regulates the turning step of male mating behavior (PubMed:17611271). Involved in reducing pharyngeal pumping in response to high CO(2) levels (PubMed:25101962).
messages: Expression is restricted to the nervous system.
messages: Perikaryon
messages: axon
messages: secretory vesicle lumen

6239:CELE W02B12.7
gene id: 6239:CELE_W02B12.7
uniprot id: Q23124
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE C53B4.5
gene id: 6239:CELE_C53B4.5
uniprot id: Q18799
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F28C6.3
gene id: 6239:CELE_F28C6.3
uniprot id: Q19864
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y53F4B.1
gene id: 6239:CELE_Y53F4B.1
uniprot id: Q9NAC7
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F54B11.1
gene id: 6239:CELE_F54B11.1
uniprot id: Q20744
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F30B5.1
gene id: 6239:CELE_F30B5.1
uniprot id: P17657
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape.

6239:CELE B0207.3
gene id: 6239:CELE_B0207.3
uniprot id: Q9BIG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with the dopamine receptor dop-2 (via C-terminus); the interaction is direct (PubMed:22280843).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In association with the G-protein coupled dopamine receptor dop-2, modulates two types of learning: touch habituation and chemosensory associative conditioning (PubMed:23607404).

6239:CELE F57C2.3
gene id: 6239:CELE_F57C2.3
uniprot id: O45595
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: Telomeric DNA-binding protein, which binds to two or more single-stranded G-rich repeat sequences (G-strand), with high specificity to the 5'-TTAGGC-3' sequence (PubMed:18329362, PubMed:23390606). In addition, repeat sequence binding requires a 3' single-stranded telomeric overhang (PubMed:18329362). Acts redundantly with pot-1 to negatively regulate telomerase-mediated telomere extension (PubMed:18329362, PubMed:23390606, PubMed:24297748). Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres) (PubMed:23390606, PubMed:22547822, PubMed:24297748). Does not appear to have a role in anchoring telomeres to the nuclear envelope (PubMed:24297748).
messages: telomere

6239:CELE H43I07.1
gene id: 6239:CELE_H43I07.1
uniprot id: A0A163VU72
uniprot id: A0A168H995
uniprot id: A0A168H9C2
names: Similarity
messages: Belongs to the OPA3 family.

6239:CELE C05H8.1
gene id: 6239:CELE_C05H8.1
uniprot id: Q3Y416
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Activated by Ca(2+)/calmodulin (PubMed:10336483, PubMed:10428833). Binding of calmodulin may relieve intrasteric autoinhibition (By similarity).
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1 (PubMed:10336483, PubMed:10428833, PubMed:12231504). Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation (PubMed:12231504).
messages: Expressed in head and tail neurons and vulval muscles.
messages: The RP domain (arginine/proline-rich) is involved in the recognition of substrates such as cmk-1.
messages: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.

6239:CELE M04C9.5
gene id: 6239:CELE_M04C9.5
uniprot id: B3WFY8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. RCK subfamily.
messages: Expressed in head neurons including amphid and labial sensory neurons and 3 pairs of neurons in the tail including phasmid sensory neurons. In male, expressed in the tail including the sensory rays and the spicule.
messages: Perikaryon
messages: Sensory neuron cilia are longer, not correctly aligned in the amphid channel, more dispersed, misdirected and sometimes turned back towards the transition zone. Abnormal localization of kap-1 along the full cilia length. Abnormal accumulation in the middle of cilia and in the distal segment and reduced speed along the cilium axoneme of components of the IFT machinery kap-1, osm-3, xbx-1, che-11 and osm-5. In a kap-1 mutant background, 30 percent of mutants have branched cilia. In a kap-1 and osm-3 double mutant background, loss of cilia formation.
messages: Serine/threonine-protein kinase which is required for ciliogenesis. Regulates the length and the morphology of sensory neuron cilia. In addition, plays a role in the anterograde intraflagellar transport (IFT) in the cilia by regulating the undocking of kinesin-II motor complex (composed of klp-11, klp-20 and kap-1) before reaching the distal segment and the docking of kinesin motor osm-3 onto IFT cargos.
messages: axon
messages: cilium
messages: dendrite

6239:CELE Y73F8A.17
gene id: 6239:CELE_Y73F8A.17
uniprot id: Q9NA55
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T25G12.7
gene id: 6239:CELE_T25G12.7
uniprot id: Q65ZI3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE C03H12.1
gene id: 6239:CELE_C03H12.1
uniprot id: G5ECV3
uniprot id: S6EZQ4
uniprot id: S6F542
uniprot id: S6FN15
names: Similarity
messages: Belongs to the glypican family.

6239:CELE F58G11.2
gene id: 6239:CELE_F58G11.2
uniprot id: P90897
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Expressed in the soma and germline.
messages: Interacts with wago-1, ergo-1 and rde-1.
messages: P-body
messages: Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing (PubMed:24684930, PubMed:24684931). Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs (PubMed:24684930, PubMed:24684931). May associate with and recruit rde-10 to primary siRNA-targeted mRNA for secondary siRNA synthesis (PubMed:24684930). May be recruited to target mRNAs by rde-1 and/or ergo-1 (PubMed:24684930, PubMed:24684931).
messages: The C-terminal region is necessary for localization to P granules.
messages: Viable with no obvious developmental defects. Insensitive to RNAi-mediated gene silencing. Increased sensitivity to viral infection.
messages: perinuclear region

6239:CELE C05E11.5
gene id: 6239:CELE_C05E11.5
uniprot id: Q17663
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C36C5.11
gene id: 6239:CELE_C36C5.11
uniprot id: A0A0S4XR90
uniprot id: O16404
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W09C5.5
gene id: 6239:CELE_W09C5.5
uniprot id: Q9XUJ7
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domain 1 binds phorbol ester with high affinity and mediates accumulation at the cell periphery. Phorbol-ester/DAG-type domain 2 binds phorbol ester with low affinity but may mediate initial contact, resulting in a conformational change allowing previously occluded domain 1 to anchor the kinase. Phosphorylation on Thr-588 is then also required for activation and may also result in a further conformational change.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC (PubMed:16613841, PubMed:16613842). Role in the regulation of growth and neuromuscular control of movement (PubMed:16613841, PubMed:16613842). Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1 (PubMed:27184844).
messages: Cytoplasm
messages: Highly expressed in embryos and at lower levels through the four larval stages in adults. Present in a region bounded by the anterior and posterior bulbs of the pharynx and an area of the tail containing the lumbar, dorsorectal and pre-anal ganglia. Expressed in neurons.
messages: Loss of movement due to severe or complete loss of muscle contraction near the anus resulting in partial paralysis of the tail region (PubMed:16613841). RNAi-mediated knockdown results in a shortened lifespan, prevents transcription factor hlh-30 nuclear translocation during S.aureus infection and reduces survival following infection (PubMed:27184844).
messages: Membrane
messages: Prolonged phosphorylation at Thr-588 results in ubiquitination and degradation.
messages: The PH domain inhibits PKD catalytic activity in the absence of DAG, either by direct steric occlusion or distortion of the PKD catalytic cleft.

6239:CELE C09G5.4
gene id: 6239:CELE_C09G5.4
uniprot id: Q09455
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE Y69A2AR.30
gene id: 6239:CELE_Y69A2AR.30
uniprot id: Q9NGT3
uniprot id: U4PC21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAD2 family.
messages: Nucleus

6239:CELE W06H3.1
gene id: 6239:CELE_W06H3.1
uniprot id: Q9XXN2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Cytoplasm
messages: Egg-laying defects, defective oogenesis in 23% of mutants, reduced brood size and increased resistance to oxidative stress inducer paraquat (PubMed:20578245, PubMed:21248201). Abnormal mitochondrial morphology with mitochondria appearing larger, thinner and connected with large pores in the outer mitochondrial membrane (PubMed:21248201). Mitochondria also have elongated and curved cristae that are stacked with a reduced number of junctions (PubMed:21248201). Double knockout with immt-1 results in a more reduced brood size and enhanced resistance to paraquat-induced oxidative stress as compared to the single mutant, and in addition, mutants are slower swimmers, have increased hydrogen peroxide-induced reactive oxygen species (ROS), and reduced mitochondrial mass accompanied by reduced superoxide anion oxidation (PubMed:20578245).
messages: Expressed in embryos.
messages: Expressed in the gonads and muscle cells.
messages: Mitochondrion inner membrane
messages: Sustains mitochondrial morphology probably through maintaining cristae morphology (PubMed:20578245, PubMed:21248201). May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).

6239:CELE C16C2.1
gene id: 6239:CELE_C16C2.1
uniprot id: P20269
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F22A3.5
gene id: 6239:CELE_F22A3.5
uniprot id: Q45EK2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TALE/PBX homeobox family.
messages: Expressed in the intestine at the L4 larval stage and persists into adulthood (PubMed:30956009, PubMed:31675356). Expressed in sensory AWC neurons, pharyngeal muscle cells pm6, and intestine, in the adult (PubMed:30956009, PubMed:31675356).
messages: Forms a heterodimer with homeobox unc-62 (PubMed:30956009, PubMed:31675356). Interacts with pqm-1 (PubMed:30956009).
messages: Nucleus
messages: Probable transcription regulator which binds to DNA, repressing genes involved in longevity and stress, while activating genes involved in reproduction, such as the vitellogenins (PubMed:30956009, PubMed:31675356). Associates with homeobox unc-62 to regulate gene expression, including repression of genes involved in innate immunity (PubMed:30956009, PubMed:31675356). Required for intestinal expression of vitellogenin genes (PubMed:30956009, PubMed:31675356). Negatively modulates longevity, probably independently of effects on vitellogenesis (PubMed:30956009). Involved in lipid homeostasis, contributing to the reallocation of intestinal lipids to the germline and to the formation of the cuticle (PubMed:30956009, PubMed:31675356). Associates with transcriptional regulator pqm-1 at the daf-16 associated element within the promoters of stress-responsive genes to regulate expression (PubMed:30956009).
messages: RNAi mediated knockdown targeted to the intestine represses expression of vitellogenin genes.

6239:CELE C27A7.1
gene id: 6239:CELE_C27A7.1
uniprot id: P90754
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Membrane
messages: Probable phosphodiesterase.

6239:CELE C01H6.5
gene id: 6239:CELE_C01H6.5
uniprot id: P41828
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Expressed in all blastomeres of the embryo from at least the 2-cell stage until approximately the 200-cell stage (at protein level) (PubMed:9521900). Expression becomes restricted mainly to epidermal cells and their precursors after 200 cell stage and during subsequent embryogenesis (at protein level) (PubMed:9521900). Expressed at high levels in newly hatched larvae, then decreases to a minimum at 4-6 hr after L1 stage larvae start feeding; expression increases for about 2 hr and decreases before each successive molt (PubMed:11416209). In L4 larvae, expressed in hypodermal cells of the head, vulval precursor cells of hermaphrodites, and hypodermal and tail cells of males (PubMed:33060131). Also expressed in the sperm-producing germlines of males and L4 hermaphrodites, but not in hermaphrodites producing only oocytes (PubMed:33060131).
messages: Expressed in the germline and oocytes and is a maternal gene product (PubMed:9521900). In males and sperm-producing hermaphrodites, expressed in early pachytene spermatocytes, increasing in level throughout late pachytene (PubMed:33060131). Expression is undetectable in meiotically dividing spermatocytes or mature spermatids (PubMed:33060131).
messages: Nucleus
messages: Orphan nuclear receptor. Transcription factor (PubMed:9521900, PubMed:21910973, PubMed:11416209, PubMed:35968765). Modulates expression of target genes, such as Period protein homolog lin-42 and microRNA let-7, by binding to hormone response elements (HRE) (PubMed:9521900, PubMed:35968765). Involved in promoting oscillatory expression of the primary transcripts of let-7 and paralogous microRNAs miR-48, miR-84, and miR-241 (PubMed:35968765). Plays a role in normal development and required to regulate each larval molt (PubMed:9521900, PubMed:11416209, PubMed:21910973). Involved in regulating both the frequency and number of molts, acting as part of a negative feedback loop with the let-7 family of microRNAs, perhaps contributing to a self-sustaining molecular-genetic oscillator (PubMed:35968765). Positively modulates expression of collagen and hedgehog-related genes (PubMed:21910973, PubMed:11416209). Involved in development of the gonad and associated epidermal structures (PubMed:11416209, PubMed:9521900). Required in spermatogenesis, acting following the sperm/oocyte cell fate decision, downstream of the canonical sex-determination pathway (PubMed:33060131). Involved in regulating formation of the sperm-specific fibrous body-membranous organelle (FB-MO) complexes, acting independently of transcription regulator spe-44 (PubMed:33060131).
messages: Post-transcriptionally repressed by let-7 microRNAs.
messages: RNAi-mediated knockdown in the adult causes abnormally small larval progeny, difficulties in shedding old cuticles after molts and larval arrest at the L3 or L4 stage (PubMed:9521900). Up to three previous cuticle segments may remain attached near the tail (PubMed:9521900). Less than 1% of affected larvae survive to adulthood and in all cases have a strong Dumpy (short and fat) phenotype (PubMed:9521900). Defects in gonad morphogenesis and seam cell (lateral epidermis) development (PubMed:9521900). Knockdown in L1 larvae causes the majority of affected individuals to have defects in the L3/L4 molt (PubMed:11416209, PubMed:35968765). Reduces the peak level of expression of fbn-1 by 2-fold during both L3 and L4 stages (PubMed:35968765). Knockdown in L2 larvae results in a molting defect mainly at the L4/adult (A) transition (PubMed:11416209). Knockdown in L3 larvae causes developmental arrest and a molting defect in the L4/A molt (PubMed:11416209). Larval molting cycles are extended; this effect is partially suppressed in a microRNA let-7 mutant background (PubMed:35968765). Those hermaphrodite adults which survive knockdown at larval stages show defects in gonad development, with gonad often appearing misshapen, folded and constricted (PubMed:11416209). Males which survive knockdown often have tail morphogenesis defects, in addition to molting defects (PubMed:11416209). Significantly (5-11 fold) reduces level of expression of cuticle collagen dpy-7 (PubMed:11416209). Germline-targeted knockdown in hermaphrodites or males causes sterility (PubMed:33060131). Primary spermatocytes arrest in a metaphase I-like state (PubMed:33060131). Spermatocytes have defects in both cytokinesis and post-meiotic partitioning (PubMed:33060131).

6239:CELE T01B7.7
gene id: 6239:CELE_T01B7.7
uniprot id: P20784
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Localizes in stripes along the alae.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis (PubMed:21094156).

6239:CELE F56F4.9
gene id: 6239:CELE_F56F4.9
uniprot id: A8DZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C44H9.1
gene id: 6239:CELE_C44H9.1
uniprot id: Q18629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE K04C2.4
gene id: 6239:CELE_K04C2.4
uniprot id: Q21209
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Autoubiquitinated.
messages: Chromosome
messages: Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity (PubMed:16628214). When bound to chromatin, the brc-1-brd-1 heterodimer within the CeBCD complex is inactive during normal conditions, but in response to DNA damage, the brc-1-brd-1 heterodimer associates with other proteins such as the recombinase rad-51 or the E2-ubiquitin-conjugating enzyme let-70, which activate the CeBCD complex as an E3-ubiquitin ligase (PubMed:16628214). Moreover, association between the brc-1-brd-1 heterodimer and rad-51 and let-70, probably requires DNA checkpoint proteins such as atl-1 and mre-11 in order to induce ubiquitination at DNA damage sites (PubMed:16628214). To this end, the brc-1-brd-1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:14711411, PubMed:30383754). Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by ionizing radiation for example (PubMed:14711411, PubMed:30383754). In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand break repair to ensure sister chromatid recombination and aid chromosome stability (PubMed:14711411).
messages: Cytoplasm
messages: DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites (PubMed:16628214). RNAi-mediated knockdown results in elevated levels of chromosome non-disjunction that manifest as a high incidence of males, impaired progeny survival and chromosome fragmentation after irradiation and elevated levels of p53-dependent germ cell death before and after irradiation (PubMed:14711411). Absence of S-phase checkpoint function.
messages: E3 ubiquitin-protein ligase activity of CeBCD complexes occurs at DNA damage sites. Following DNA damage, E3 ubiquitin-protein ligase activity is reduced by caffeine treatment (inhibitor of ATM and ATK kinase activity).
messages: Heterodimer (via RING-type zinc finger) with brc-1 to form the core CeBCD complex (PubMed:16628214). Brc-1-brd-1 heterodimer-containing CeBCD complexes bound to chromatin are activated as an E3-ubiquitin ligase in response to DNA damage (PubMed:16628214). The heterodimer interacts with the recombinase rad-51 following ionizing irradiation; the interaction is direct (PubMed:16628214). The heterodimer interacts the E2-ubiquitin-conjugating enzyme let-70 following ionizing irradiation (PubMed:16628214). The heterodimer interacts with the pro-crossover proteins msh-5 and syp-3 (PubMed:30383754). Interacts with smt-3, tac-1 and ubc-9 (PubMed:14711411).
messages: Nucleus
messages: Phosphorylation of CeBCD complexes is required for E3 ubiquitin-protein ligase activity.

6239:CELE F21A3.3
gene id: 6239:CELE_F21A3.3
uniprot id: O17829
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F43C1.2
gene id: 6239:CELE_F43C1.2
uniprot id: P39745
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Activated by dual phosphorylation at Thr-256 and Tyr-258 (PubMed:20624915). May be inactivated by lip-1-mediated dephosphorylation (PubMed:21901106).
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Expressed in cells lining the rectum (PubMed:15268855, PubMed:20624915). Isoform a is expressed in nervous system, body wall muscles and posterior intestine (PubMed:20624915). Isoform b expression may be restricted to germline (PubMed:22820175).
messages: Functions in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation (PubMed:8299935, PubMed:8299936). Plays a negative role in proximal germline proliferation in the mitotic zone (PubMed:16319922). Required for progression of developing oocytes through the pachytene stage, perhaps acting after efl-1/dpl-1-mediated gene activation and before gld-1 down-regulation (PubMed:16319922, PubMed:19826475, PubMed:21901106, PubMed:17096596). May play a role in global X chromosome reactivation or be indirectly required for progression of germ cells through meiosis to the point where X reactivation occurs (PubMed:17096596). In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3 (PubMed:21160027). Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation (PubMed:15268855). Involved in fluid homeostasis (PubMed:11689700). In addition, involved in the up-regulation of lysozyme ilys-3 expression in the intestine in responses to M.nematophilum-mediated bacterial infection (PubMed:27525822). By phosphorylating transcription factor skn-1 (isoform c) may play a role in increasing life span downstream of lin-45, let-60 and mek-2 (PubMed:20624915). By up-regulating cep-1 and down-regulating gld-1 expression in the late pachytene stage, plays a role in germline apoptosis in response to DNA damage (PubMed:21901106). Regulates egl-1 expression in response to DNA damage, probably upstream of cep-1 (PubMed:21901106).
messages: Isoform a interacts with gck-1 (via N-terminus).
messages: Isoform a is phosphorylated at the pachytene stage during oogenesis and is negatively regulated by gck-1. Isoform b is phosphorylated in proximal oocytes.
messages: RNAi-mediated knockdown causes an increase in the number of germline cells in the mitotic zone, a lack of transition zone and a defect in pachytene progression resulting in a proximal gonad devoid of nuclei (PubMed:19826475, PubMed:16319922). Causes sterility (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915). RNAi-mediated knockdown of isoform b in lip-1 and puf-8 double mutant causes a decrease in number of germline tumors (PubMed:22820175). RNAi-mediated knockdown causes a reduction in intestinal ilys-3 expression in response to M.nematophilum-mediated bacterial infection (PubMed:27525822).
messages: Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably upstream of rskn-1.
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
messages: The phosphorylated form is present in early to mid pachytene, is absent in late pachytene and diplotene/diakinesis stages and is again present in oocytes when they reach the spermatheca (PubMed:19826475, PubMed:21901106, PubMed:22820175). The phosphorylated form is also present in sperm (PubMed:22820175).

6239:CELE C10H11.1
gene id: 6239:CELE_C10H11.1
uniprot id: P91041
names: Similarity
messages: Belongs to the villin/gelsolin family.

6239:CELE T27D12.1
gene id: 6239:CELE_T27D12.1
uniprot id: D1MN75
uniprot id: Q22832
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F59A6.3
gene id: 6239:CELE_F59A6.3
uniprot id: Q21027
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T19D12.9
gene id: 6239:CELE_T19D12.9
uniprot id: O76837
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T10B10.7
gene id: 6239:CELE_T10B10.7
uniprot id: Q22374
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C44C10.8
gene id: 6239:CELE_C44C10.8
uniprot id: Q18612
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Adults are viable and fertile, but with a moderate frequency of somatic gonad defects, which increases on an ehn-3 mutant background (PubMed:12756172). Low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hlh-1 or unc-120 mutant background (PubMed:12756172, PubMed:15892873, PubMed:17142668). Many embryos that survive to hatch become uncoordinated, dumpy larvae with variable body shape defects, typically in the posterior (PubMed:15892873, PubMed:12756172). One quarter of the embryos from homozygous hnd-1;hlh-1 heterozygous parents exhibit reduced expression of myosin myo-3 (PubMed:17142668). On a unc-120 mutant background, progeny show reduced expression of myo-3 at mid-embryogenesis (PubMed:17142668). RNAi-mediated knockdown results in abnormal number and positioning of the somatic gonadal precursor cells (SGPs) and influences the maintenance of primordial germ cells (PGCs) in L1 larvae (PubMed:15892873).
messages: Expressed in the MS, C and D embryonic lineages, which develop into somatic gonadal precursor cells (SGPs), other mesodermal cells and bodywall muscle (PubMed:12756172). Expression is abolished in most body muscle cells by the comma stage of embryogenesis, but continues in the SGPs (Z1 and Z4), and then is abolished shortly after assembly of the gonadal primordium (PubMed:12756172).
messages: Nucleus
messages: Probable transcription factor which regulates early embryonic myogenesis, in cooperation with transcription factors unc-120 and hlh-1 (PubMed:15892873, PubMed:17142668). Involved in controlling the number and position of somatic gonadal precursor cells (SGPs) in the gonadal primordium, and embryonic body shape (PubMed:12756172).

6239:CELE C42D8.3
gene id: 6239:CELE_C42D8.3
uniprot id: Q18580
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

6239:CELE C46F11.1
gene id: 6239:CELE_C46F11.1
uniprot id: Q93380
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the unc-93 family.
messages: Cell membrane
messages: Defective extension of body wall muscle connections or arms towards the ventral nerve cord. Double knockout with madd-3 results in severe muscle arm extension defects.
messages: Gain of function phenotype is phenocopied by exposure to the unc-49 agonist muscimol.
messages: Low levels in body-wall muscles, eight vulval muscles, intestinal muscles and a subset of head neurons.
messages: May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex (PubMed:1313436, PubMed:14534247). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
messages: May form a complex with sup-9 and sup-10 where unc-93 and sup-10 act as regulatory subunits of the two pore potassium channel sup-9.
messages: More highly expressed in L1 larvae than in eggs and adults.

6239:CELE B0024.2
gene id: 6239:CELE_B0024.2
uniprot id: Q17418
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C25F6.7
gene id: 6239:CELE_C25F6.7
uniprot id: H2KZ11
uniprot id: Q8MQC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

6239:CELE Y38A10A.5
gene id: 6239:CELE_Y38A10A.5
uniprot id: P27798
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: By ER stress in an xbp-1-dependent manner (PubMed:24933177). By aging (PubMed:32905769).
messages: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).
messages: Cleaved by caspase ced-3 in vitro.
messages: Endoplasmic reticulum lumen
messages: Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis (PubMed:20153198). Protects dopaminergic neurons against oxidative stress-induced neurodegeneration (PubMed:29346364). May play a role in protection against ER stress (PubMed:24933177). Plays a role in modulating lifespan, acting by influencing ER calcium homeostasis (PubMed:32905769).
messages: RNAi-mediated knockdown in a vab-10(e698) mutant background causes 45 percent embryonic lethality. In the surviving animals, causes a 14 percent larval lethality associated with the detachment of muscles from the epidermis.
messages: The interaction with glycans occurs through a binding site in the globular lectin domain.
messages: The zinc binding sites are localized to the N-domain.

6239:CELE C50A2.4
gene id: 6239:CELE_C50A2.4
uniprot id: O44138
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

6239:CELE F56D12.1
gene id: 6239:CELE_F56D12.1
uniprot id: G4RZC3
uniprot id: G5EC31
uniprot id: Q86N72
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6239:CELE C52A10.2
gene id: 6239:CELE_C52A10.2
uniprot id: Q95YC3
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE T20B12.6
gene id: 6239:CELE_T20B12.6
uniprot id: P41846
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in epidermal cells as early as the 50-100 cell stage of embryogenesis and in intestinal cells at the 4E stage (PubMed:17826759). Expressed in non-migratory, syncytial epidermis at larval stage L1 (PubMed:17826759).
messages: Expressed in intestine, neurons, muscle, hypodermis, excretory cell and other tissues.
messages: Mitochondrion
messages: Nucleus
messages: RNAi-mediated knockdown reduces lifespan, which is further reduced on daf-2 or glp-1 mutant backgrounds (PubMed:24699255, PubMed:27001890). RNAi-mediated knockdown causes premature onset of polyglutamine-mediated paralysis (PubMed:24699255). RNAi-mediated knockdown increases spore levels of the microsporidian pathogen N.parisii during infection, on an mxl-2 or mdl-1 mutant background (PubMed:27402359).
messages: Transcription factor that binds to the E box motif 5'-CACGTG-3', probably in a heterodimeric complex with mxl-2 (PubMed:17826759). Involved in modulating longevity in response to TOR signaling, dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and the insulin-like signaling pathway (PubMed:24699255, PubMed:27001890). Plays a role in autophagy (PubMed:27001890). Involved in regulating migration of the ray 1 precursor cells in the male tail, acting in concert with Wnt and semaphorin signaling pathways (PubMed:17826759). Regulates transcription of genes encoding extracellular matrix (ECM) components which may contribute to the substratum required for migration of the neighboring ray 1 precursor cells (PubMed:17826759). Involved in repressing infection by the microsporidian pathogen N.parisii, probably acting independently of its canonical partner, mxl-2 (PubMed:27402359).

6239:CELE C16A11.2
gene id: 6239:CELE_C16A11.2
uniprot id: H2KYD0
names: Similarity
messages: Belongs to the CCDC93 family.

6239:CELE R08E3.4
gene id: 6239:CELE_R08E3.4
uniprot id: H2L008
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Ikaros C2H2-type zinc-finger protein family.
messages: Expressed from embryos to adults (PubMed:20026024). First expressed in somatic gonadal precursor cells during embryogenesis (PubMed:20026024). In the L2 larval stage of development, expressed in Z1.pa and Z4.ap distal tip cells and their descendants (PubMed:20026024).
messages: Expressed in the somatic gonad, hypodermis and cells in the head and tail (PubMed:20026024). Expressed in amphid and phasmid sheath glia, amphid and phasmid socket glia, and in neurons in the head (PubMed:22298710).
messages: Nucleus
messages: Positively regulates the expression of ver-1 in the amphid sheath glia of amphid sensory neurons (PubMed:22298710). Together with ehn-3, plays a role in somatic gonad development and is required for proper gonadal primordium assembly and somatic gonad precursor cell morphology (PubMed:20026024).
messages: RNAi-mediated knockdown does not cause defects in somatic gonad development (PubMed:20026024). RNAi-mediated knockdown in a ehn-3 rd2 mutant background enhances the defects in gonadal development in the ehn-3 single mutant (PubMed:20026024).

6239:CELE C04G6.5
gene id: 6239:CELE_C04G6.5
uniprot id: Q17638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Membrane

6239:CELE T23B12.6
gene id: 6239:CELE_T23B12.6
uniprot id: O17001
names: Similarity
messages: Belongs to the KCTD3 family.

6239:CELE F54D5.1
gene id: 6239:CELE_F54D5.1
uniprot id: A5JYS0
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Sequence Caution
names: Similarity
names: Tissue Specificity
messages: Belongs to the phytochelatin synthase family.
messages: Expressed in hypodermis, pharyngeal grinder, pharyngeal-intestinal valve, body wall and vulval muscles, and coelomocytes (PubMed:20221439). Expressed in posterior pharyngeal cells and anal valve (PubMed:24333255, PubMed:26907254).
messages: Induced by zinc oxide nanoparticles in intestinal cells (PubMed:24333255). However, not induced by zinc or cadmium (PubMed:26907254).
messages: Involved in the synthesis of phytochelatins, which are heavy metal binding proteins required for the detoxification of heavy metals such as cadmium, arsenic and copper.
messages: Probable cloning artifact.
messages: RNAi-mediated knockdown causes hypersensitivity to Cd(2+), specifically causes a reduction in growth, impairs development and reduces fertility.
messages: Requires cadmium for activity.

6239:CELE C41G6.7
gene id: 6239:CELE_C41G6.7
uniprot id: O17660
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y110A7A.11
gene id: 6239:CELE_Y110A7A.11
uniprot id: Q9N598
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

6239:CELE F20A1.9
gene id: 6239:CELE_F20A1.9
uniprot id: Q19614
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the germline.

6239:CELE T09A12.2
gene id: 6239:CELE_T09A12.2
uniprot id: H2KYJ6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE T20B12.9
gene id: 6239:CELE_T20B12.9
uniprot id: P41849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Postsynaptic cell membrane

6239:CELE Y55F3AL.1
gene id: 6239:CELE_Y55F3AL.1
uniprot id: Q3V5K0
uniprot id: U4PBW0
uniprot id: U4PF39
uniprot id: U4PRY7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F44C8.4
gene id: 6239:CELE_F44C8.4
uniprot id: O16359
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F32A5.7
gene id: 6239:CELE_F32A5.7
uniprot id: Q19952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

6239:CELE R11A5.2
gene id: 6239:CELE_R11A5.2
uniprot id: O45717
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nudE family.
messages: Component of a dynein-regulating complex composed of at least lis-1 and nud-2 (PubMed:20005871). Interacts with lis-1; the interaction is direct (PubMed:16996038). Interacts (via C-terminus) with unc-83; the interaction is direct, and is required for recruitment of nud-2 to the nuclear envelope (PubMed:20005871).
messages: Expressed in ventral cord neurons, the pharynx, seam cells of the hypodermis and in vulval muscle cells.
messages: Nucleus envelope
messages: Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).
messages: RNAi-mediated knockdown results in viable animals, but a small, but significant number of animals have nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in impaired locomotion, stiffened appearance and an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).

6239:CELE C02C2.5
gene id: 6239:CELE_C02C2.5
uniprot id: P34273
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nitroreductase family.
messages: Expressed in body-wall, anal depressor and vulval muscles.
messages: May contribute to coordination of muscle contraction as regulatory subunit of the nonessential sup-9 potassium channel complex. May act downstream of sup-10.
messages: Membrane
messages: No visible phenotype. Fully suppresses the rubber band uncoordinated phenotype in gain of function (gf) mutants of sup-10 but only slightly in gf mutants of sup-9 and unc-93.

6239:CELE Y111B2A.1
gene id: 6239:CELE_Y111B2A.1
uniprot id: Q9BHM0
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE K06A4.1
gene id: 6239:CELE_K06A4.1
uniprot id: Q21252
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE K09A11.3
gene id: 6239:CELE_K09A11.3
uniprot id: Q27505
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T27E9.3
gene id: 6239:CELE_T27E9.3
uniprot id: G5ECH7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Binds 2 Mg(2+) ions.
messages: Cytoplasm
messages: Heterodimer composed of a catalytic subunit cdk-5 and a regulatory subunit cdka-1. Interaction with cdka-1 is required for cdk-5 activation.
messages: Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1 (PubMed:17671168, PubMed:21609829). Involved in the inhibition of glr-1 trafficking in hypoxic conditions (PubMed:22252129). In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport (PubMed:20510931). Regulates the trafficking of dense-core vesicles in DA and DB motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite (PubMed:22699897). May regulate these processes in association with cdka-1/p35 (PubMed:17671168, PubMed:20510931). Activity may be regulated by cyy-1 (PubMed:20510931). Involved in synapse formation during DD motor neuron remodeling by regulating transport of disassembled synaptic material to the new synaptic sites probably by activating the motor protein unc-104/kinesin-3 (PubMed:21609829). Regulates microtubule polarity in the dendrite of DB motor neurons (PubMed:22699897). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).
messages: Several glr-1-dependent behaviors are affected including an absence of backward locomotion after nose-touching stimuli and a reduction in reverse locomotion (PubMed:17671168). In L4 mutants, incomplete elimination of ventral rab-3-positive synaptic vesicles associated with a delay in the formation of dorsal rab-3-positive synaptic vesicles in DD motor neurons. Normal formation of ventral synapses in DD motor neurons at the L1 stage (PubMed:21609829). In addition, mutants have an increase in anterograde dense-core vesicle trafficking and in the number of plus-end-out microtubules in DB motor neuron dendrites (PubMed:22699897). Reduced sensitivity to the acetylcholine esterase inhibitor aldicarb (PubMed:22699897). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).
messages: dendrite

6239:CELE F17A2.7
gene id: 6239:CELE_F17A2.7
uniprot id: Q19505
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F37C12.3
gene id: 6239:CELE_F37C12.3
uniprot id: Q20122
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

6239:CELE C02E11.1
gene id: 6239:CELE_C02E11.1
uniprot id: H2KYE0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Expressed in body wall, pharyngeal, uterine and vulval muscles, motor neurons, nerve ring, motor and ventral cord neurons, hypodermal cells in the tail, vulval epithelium and intestine.
messages: Expressed in embryos and adults.
messages: Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER) (PubMed:19609303). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER (PubMed:19609303). Specifically, may promote the inclusion of alpha subunit unc-38 into and the exclusion of unc-29 from L-AChR (PubMed:19609303). Regulates L-AChR sensitivity to agonists such as nicotine and levamisole at neuro-muscular junctions (PubMed:19609303).
messages: May interact with nra-2 in the ER.

6239:CELE T09D3.6
gene id: 6239:CELE_T09D3.6
uniprot id: Q86B34
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE C36A4.6
gene id: 6239:CELE_C36A4.6
uniprot id: Q27479
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE K09B11.5
gene id: 6239:CELE_K09B11.5
uniprot id: Q2EEM6
uniprot id: Q9U3B5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F31D5.1
gene id: 6239:CELE_F31D5.1
uniprot id: Q19933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE F32D8.4
gene id: 6239:CELE_F32D8.4
uniprot id: Q19965
names: Similarity
messages: Belongs to the PIH1 family.

6239:CELE Y48E1C.2
gene id: 6239:CELE_Y48E1C.2
uniprot id: O62483
names: Similarity
messages: Belongs to the carnosine N-methyltransferase family.

6239:CELE T20F10.1
gene id: 6239:CELE_T20F10.1
uniprot id: O45797
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Expressed at the embryonic comma stage and during all the larval stages and in adults.
messages: Expressed in muscles and epithelial tissues including pharynx, intestine and hypodermis (PubMed:19605499). Expressed in vulval and spermathecal seam cells (PubMed:19737560).
messages: Interacts (via N-terminus) with yap-1 (via WW domain).
messages: Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization (PubMed:23396260). Plays an essential role in larval development (PubMed:19737560, PubMed:19605499). Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway (PubMed:19737560). Does not appear to regulate apoptosis and proliferation (PubMed:19605499). In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage (PubMed:19737560). Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins (PubMed:19605499).
messages: RNAi-mediated knockdown results in larval lethality in 50 percent of the animals (PubMed:19737560, PubMed:19605499). Surviving knockdown animals have several defects including a slower growth and a partial distortion of the pharynx. In surviving L3 animals seam cells are 30 percent smaller (PubMed:19737560).

6239:CELE Y66D12A.9
gene id: 6239:CELE_Y66D12A.9
uniprot id: Q95PZ7
names: Similarity
messages: Belongs to the PA28 family.

6239:CELE Y40B10A.6
gene id: 6239:CELE_Y40B10A.6
uniprot id: Q965W4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6239:CELE F44C4.5
gene id: 6239:CELE_F44C4.5
uniprot id: Q20390
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Removes thioester-linked fatty acyl groups such as palmitate (hexadecanoate) from modified cysteine residues in proteins or peptides.
messages: Worms exhibit a developmental delay and mild reproductive defects. They have abnormal mitochondria in muscle and neuronal cells.

6239:CELE C54A12.4
gene id: 6239:CELE_C54A12.4
uniprot id: Q09930
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Di-Ras family.
messages: Cell membrane
messages: Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1 (PubMed:22897658).
messages: Expressed specifically in neurons including the nerve ring, ventral and dorsal nerve cord motor neurons and tail ganglia.
messages: Interacts with epac-1 (via C-terminus).
messages: Viable and fertile. Resistant to paralysis induced by treatment with acetylcholinesterase inhibitor aldicarb (but not with acetylcholine agonist levamisole). Hypersensitivity to aldicarb treatment is partially reduced in an egl-30(js126), goa-1(n1134) or gsa-1(ce94) mutant background.

6239:CELE K10B4.5
gene id: 6239:CELE_K10B4.5
uniprot id: O17240
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y39G10AL.3
gene id: 6239:CELE_Y39G10AL.3
uniprot id: G5EFV5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Catalytic component which, in association with cyclin H (cyh-1) and mat1, is likely to form the CAK complex.
messages: RNAi-mediated knockdown results in an arrest at approximately 50-cell embryonic stage. The phenotype is more severe when done in a cdk7(ax224) mutant background where the embryonic arrest occurs at the 1-cell stage due to an arrest in early meiosis.
messages: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1.

6239:CELE R07B7.13
gene id: 6239:CELE_R07B7.13
uniprot id: N1NTC6
uniprot id: Q21803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C15A7.4
gene id: 6239:CELE_C15A7.4
uniprot id: A5JYS3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K06C4.12
gene id: 6239:CELE_K06C4.12
uniprot id: Q27894
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C26E6.8
gene id: 6239:CELE_C26E6.8
uniprot id: Q18217
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Heterodimer of uba-3 and ula-1. The complex binds NEDD8 and ubc-12 (By similarity).
messages: RNAi-mediated knockdown causes the formation of an everted vulva in the L4 stage, with the subsequent rupture of the animal during the L4-to-adult molt (PubMed:10993680). Loss of rfl-1 nuclear localization in a 1- to 2-cell embryonic stages (PubMed:19528325).
messages: Regulatory subunit of the dimeric uba-3-ula-1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-rfl-1 (uba-3) thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc-12 (PubMed:10993680). Required for rfl-1 (uba-3) nuclear localization during early embryonic development (PubMed:19528325).

6239:CELE F48F7.2
gene id: 6239:CELE_F48F7.2
uniprot id: Q20574
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane
messages: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

6239:CELE T03D3.1
gene id: 6239:CELE_T03D3.1
uniprot id: O16988
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK899.4
gene id: 6239:CELE_ZK899.4
uniprot id: P52274
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6239:CELE ZC64.3
gene id: 6239:CELE_ZC64.3
uniprot id: P41934
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the POU transcription factor family.
messages: Directs gonadal sheath cell differentiation and function (PubMed:9405097). Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development (PubMed:7958868). Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis (PubMed:7958868). Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization (PubMed:12533508). May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in response to fungal infection (PubMed:30036395).
messages: Expressed in the gonadal sheath cells that signal the oocyte, but not in the oocyte.
messages: First expressed in embryos at the three-fold stage (PubMed:7958868). After hatching expressed in the syncytial hypodermal cells located throughout the body, pharyngeal muscle, seam cells P hypodermal blast cells, body muscle and anterior touch cells (PubMed:7958868). Expressed in the distal tip cell of the somatic ginad from the L2 stage of larval development through to the adult stage (PubMed:7958868).
messages: Interacts with akir-1.
messages: Nucleus
messages: Viable, but some animals exhibit sterile and lethal phenotypes including hermaphrodite sterility, embryonic lethality and larval arrest (PubMed:7958868). Defective ovulation and terminal differentiation of oocytes, which result from a delay or an inability to complete meiosis during oogenesis (PubMed:7958868, PubMed:9405097). Defects in gonadal migration (PubMed:7958868). Defective sheath cell differentiation in terms of cell shape and position and defective functions which include weaker sheath cell contractions (PubMed:9405097). Abnormal hypodermal cell differentiation (PubMed:7958868). Defective MAPK activation in oocytes in the presence and absence of sperm (PubMed:12533508). RNAi-mediated knockdown reduces survival following fungal infection by D.coniospora (PubMed:30036395).

6239:CELE C10F3.5
gene id: 6239:CELE_C10F3.5
uniprot id: G8JY24
uniprot id: Q27873
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins.
messages: Monomer.
messages: cytosol

6239:CELE R09F10.3
gene id: 6239:CELE_R09F10.3
uniprot id: Q23026
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 27 family.
messages: Nucleus

6239:CELE ZK488.5
gene id: 6239:CELE_ZK488.5
uniprot id: O17019
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F56D1.3
gene id: 6239:CELE_F56D1.3
uniprot id: Q10129
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS16 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE F09F3.6
gene id: 6239:CELE_F09F3.6
uniprot id: O17776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T04A11.6
gene id: 6239:CELE_T04A11.6
uniprot id: O18017
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Negatively regulates sister chromatid exchange (SCE) (PubMed:27010650). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
messages: Belongs to the helicase family. RecQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Chromosome
messages: Component of the BTR double Holliday Junction dissolution complex, which is involved in homologous recombination during meiotic double strand break in the germline (Probable). Stabilizes and positively regulates the localization of the BTR double Holliday Junction dissolution complex component rmh-1 at nuclear foci during meiotic recombination (PubMed:27011106). Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) (PubMed:27010650).
messages: Monomer (By similarity). Homodimer (via N-terminus) (By similarity). Homotetramer (via N-terminus); dimer of dimers (By similarity). Homohexamer (via N-terminus) (By similarity). Self-association negatively regulates DNA unwinding amplitude and rate (By similarity). Oligomer forms dissociate into monomer in presence of ATP (By similarity). Component of the BTR double Holliday Junction dissolution complex composed of at least him-6, top-3, rmh-1 and rmif-2, which is involved in double strand break repair in the germline (Probable). May interact with rmh-1; the interaction is required for mutual stability and localization at nuclear foci (PubMed:27011106). Forms a complex composed of cdc-48.1, him-6 and crp-1; within the complex, interacts with cdc-48.1 (PubMed:18458060).
messages: Nucleus
messages: Reduced viability, increased rad-51 foci in the germline and an increase of meiotic crossover formation in the central region of chromosomes (PubMed:27010650). Reduced number of rmh-1 foci in the pachytene region (PubMed:27011106). In an smc-5 mutant background, defects in diakinetic chiasmata formation, compromised chromosome segregation and aberrant distribution of the condensin II subunit hcp-6 in meiosis (PubMed:27010650).
messages: The N-terminal region mediates dimerization and homooligomerization. Both the helicase ATP-binding domain and the helicase C-terminal domain form intramolecular interactions with the HRDC domain in a ATP-dependent manner. The HRDC domain is required for single-stranded DNA (ssDNA) and DNA Holliday junction binding.

6239:CELE ZC204.2
gene id: 6239:CELE_ZC204.2
uniprot id: P91547
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE W01A8.1
gene id: 6239:CELE_W01A8.1
uniprot id: A8WHP8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the perilipin family.
messages: Expressed from embryos to adults (PubMed:26357594). First expressed at the 3-fold stage of embryonic development (PubMed:26357594). Highly expressed in embryos (PubMed:26025681).
messages: Expressed in intestinal and epidermal cells (PubMed:26357594). Expressed in the muscle and hypodermis (PubMed:26025681).
messages: Lipid droplet
messages: Lipid droplet-associated protein which plays a role in lipid droplet clustering (PubMed:26121959, PubMed:26025681, PubMed:26357594).
messages: Viable, and able to reproduce normally, but embryos contain large lipid droplets (PubMed:26121959, PubMed:26357594). Reduced body fat accumulation (PubMed:26121959). Lipid droplets cluster in intestinal cells and contain a reduced amount of triglycerides (PubMed:26025681). RNAi-mediated knockdown results in a reduced brood size (PubMed:26357594).

6239:CELE C24F3.4
gene id: 6239:CELE_C24F3.4
uniprot id: F3Y5P6
uniprot id: Q9XXK6
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

6239:CELE C40H1.1
gene id: 6239:CELE_C40H1.1
uniprot id: Q03571
names: Developmental Stage
names: Function
names: Subunit
messages: Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.
messages: Interacts with fbf-1.
messages: Present in the germline just prior to overt spermatogenesis; once sperm differentiation begins, it disappears.

6239:CELE F22D6.9
gene id: 6239:CELE_F22D6.9
uniprot id: Q27494
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE K10B3.9
gene id: 6239:CELE_K10B3.9
uniprot id: P37209
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Does not seem to include a transit peptide.
messages: Mitochondrion
messages: Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.

6239:CELE K03A11.2
gene id: 6239:CELE_K03A11.2
uniprot id: Q21168
names: Similarity
messages: Belongs to the complexin/synaphin family.

6239:CELE T03D8.1
gene id: 6239:CELE_T03D8.1
uniprot id: Q9XTY6
names: Developmental Stage
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed at each stage of development with predominance of isoform c in early larvae and isoform a in adults.
messages: Expressed in cells comprising the intestine, pharyngeal cells, the anal sphincter and depressor muscles.
messages: Interacts with pkc-3.
messages: Involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase. The complex formed with pkc-3 complexes are likely to be involved in assembly, maintenance, and/or regulation of protein complexes that execute asymmetric and/or polarized cell functions.
messages: Membrane
messages: Produced by alternative initiation at Met-45 of isoform a.
messages: Produced by alternative splicing.
messages: The PID domain (phosphotyrosine interaction domain) of isoform a and isoform c is capable of binding residues 212-224 of pkc-3.
messages: cell cortex
messages: cytoskeleton

6239:CELE C05D11.6
gene id: 6239:CELE_C05D11.6
uniprot id: D7SFI4
uniprot id: D7SFI5
uniprot id: P55112
names: Caution
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Digestive tract. Found in the pharynx cells of the procorpus, metacorpus, isthmus and terminal bulb, and in the terminal bulb lumen.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Metalloprotease (By similarity). May be involved in digestion.
messages: Secreted

6239:CELE C02F12.1
gene id: 6239:CELE_C02F12.1
uniprot id: Q11098
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Expressed in dopaminergic neurons, head muscles, vulva and spermatheca.
messages: In larvae, expressed in the NSM serotonergic neuron and in muscles.
messages: Protects dopaminergic neurons against oxidative stress-induced neurodegeneration (PubMed:25474638, PubMed:29346364). May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity (PubMed:25474638). Also plays a role in modulating behaviors linked to dopamine signaling (PubMed:25474638). Confers protection against oxidative stress in the whole body (PubMed:29346364).
messages: axon
messages: dendrite

6239:CELE W01A8.8
gene id: 6239:CELE_W01A8.8
uniprot id: A0A0K3AUA4
uniprot id: Q09EE8
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

6239:CELE M79.4
gene id: 6239:CELE_M79.4
uniprot id: Q9XVX1
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons. Flp-19 is expressed in the URX interneurons, the serotonin and acetylcholine-expressing HSN neurons, and the AIN, AWA and BAG neurons.
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides. WANQVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: Secreted

6239:CELE F59H5.1
gene id: 6239:CELE_F59H5.1
uniprot id: Q9TZI4
names: Domain
names: Function
names: Subunit
names: Tissue Specificity
messages: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1.
messages: Expressed in some neurons including the head and tail neurons, HSN and VC, in a subset of glial cells, in the distal tips cells and in the intestine.
messages: Interacts (via GBA motif) with guanine nucleotide-binding protein G(o) subunit alpha goa-1 (in GDP-bound form); the interaction leads to activation of goa-1.
messages: The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).

6239:CELE R10E11.8
gene id: 6239:CELE_R10E11.8
uniprot id: Q21898
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adult H-shaped excretory cell and rectum.
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: High levels during embryogenesis, moderate levels during L1 and adult stages and very low levels during L2-L4 stages.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad (PubMed:29168500). This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization (PubMed:29168500). The introduction of sperm triggers V-ATPase accumulation in proximal oocytes and induces lysosomal acidification which leads to engulfing of protein aggregates by lysosomes and subsequent clearance of the aggregates (PubMed:29168500). Lysosomal acidification also leads to changes in mitochondrial morphology and function (PubMed:29168500). Mitochondria in distal immature oocytes are fragmented, produce high levels of reactive oxygen species (ROS) and have high membrane potential, indicative of metabolic inactivity (PubMed:29168500). In contrast, mitochondria in proximal mature oocytes are tubular with lower ROS levels and membrane potential, indicative of an active metabolic state required for aggregate mobilization before clearance (PubMed:29168500). Plays a role in the processing and secretion of the aspartic protease hrg-7 from the intestine (PubMed:28581477). During embryonic development, the V-ATPase is required to repress fusion of epidermal cells probably by negatively regulating eff-1-mediated cell fusion (PubMed:15866168). Involved in receptor-mediated endocytosis (PubMed:16785323).
messages: RNAi-mediated knockdown causes embryonic lethality (PubMed:16785323). RNAi-mediated knockdown results in increased protein aggregation in the oocytes of sperm-deficient young adult females which is not eliminated by mating (PubMed:29168500). RNAi-mediated knockdown causes hyperfusion of embryonic epidermal cells (PubMed:15866168). RNAi-mediated knockdown results in the accumulation of the aspartic protease hrg-7 in its immature uncleaved form and in the intestine (PubMed:28581477). Causes defects in alae formation in the few surviving larvae and impairs yolk uptake by the oocytes from the pseudoceolomic cavities (PubMed:16785323). Causes an increase in the section of the excretory canal, which often has multiple lumens and abnormal whorls (PubMed:16785323).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity).

6239:CELE Y71H10B.1
gene id: 6239:CELE_Y71H10B.1
uniprot id: Q95X21
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

6239:CELE T08D2.6
gene id: 6239:CELE_T08D2.6
uniprot id: A4F323
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

6239:CELE C09G4.5
gene id: 6239:CELE_C09G4.5
uniprot id: Q9GYS1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the WD repeat ESC family.
messages: Double RNAi-mediated knockdown together with mes-2 RNAi results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). This ectopic expression of egl-5 in the head region is enhanced in a nfya-1 bp4 mutant background (PubMed:17574230). In addition in this background in males, there is ectopic expression of egl-5 in the mid-body region including in seam cells and hypodermal nuclei, and there is ectopic ray formation (PubMed:17574230).
messages: Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed.
messages: In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells.
messages: Interacts directly with the N-terminal domain of mes-2. Forms a heterotrimeric complex with mes-2 and mes-3. Does not interact with mes-4.
messages: Nucleus
messages: Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head (PubMed:17574230). PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells (PubMed:12077420, PubMed:15380065). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259).

6239:CELE K08E4.6
gene id: 6239:CELE_K08E4.6
uniprot id: Q21336
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6239:CELE T08B2.10
gene id: 6239:CELE_T08B2.10
uniprot id: O01692
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

6239:CELE E02H1.2
gene id: 6239:CELE_E02H1.2
uniprot id: Q09523
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

6239:CELE B0304.5
gene id: 6239:CELE_B0304.5
uniprot id: Q10934
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F18A1.5
gene id: 6239:CELE_F18A1.5
uniprot id: Q19537
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

6239:CELE W10G11.16
gene id: 6239:CELE_W10G11.16
uniprot id: A0A1N7SYR3
uniprot id: A0A1N7SYW0
uniprot id: A0A1N7SZF8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F49C12.11
gene id: 6239:CELE_F49C12.11
uniprot id: Q20588
names: Similarity
messages: Belongs to the TMA7 family.

6239:CELE C34B2.7
gene id: 6239:CELE_C34B2.7
uniprot id: O44954
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

6239:CELE ZK1320.12
gene id: 6239:CELE_ZK1320.12
uniprot id: Q7YTH5
uniprot id: Q8WQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

6239:CELE K07A1.11
gene id: 6239:CELE_K07A1.11
uniprot id: P90917
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (By similarity). Interacts with zft-11; the interaction is required to suppress the activation of non-neuronal genes in neurons (PubMed:31386623).
messages: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression (PubMed:25446273). Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis (PubMed:31386623).
messages: Nucleus
messages: RNAi-mediated knockdown results in delayed cell cycle progression.

6239:CELE C01F1.2
gene id: 6239:CELE_C01F1.2
uniprot id: Q17557
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

6239:CELE F41E6.9
gene id: 6239:CELE_F41E6.9
uniprot id: O16458
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE F09G8.4
gene id: 6239:CELE_F09G8.4
uniprot id: P34389
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Both ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer-constitutive (daf-c) phenotype).
messages: Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons (PubMed:10801441).
messages: Membrane

6239:CELE C36B1.7
gene id: 6239:CELE_C36B1.7
uniprot id: Q93341
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

6239:CELE Y55F3BL.6
gene id: 6239:CELE_Y55F3BL.6
uniprot id: U4PMP9
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE AC3.7
gene id: 6239:CELE_AC3.7
uniprot id: Q17403
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C14C10.6
gene id: 6239:CELE_C14C10.6
uniprot id: G5EEQ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Expressed in tissues including muscles, intestine and neurons.
messages: Hypersensitive to the acetylcholinesterase inhibitor aldicarb. In a slo-1 (ky399gf) gain of function mutant, restores normal locomotory speed and sensitivity to aldicarb.
messages: Promotes the translocation of slo-1 potassium ion channels from the endoplasmic reticulum to its final destination at the plasma membrane, probably by shielding from premature proteasomal degradation in the endoplasmic reticulum.
messages: dendrite

6239:CELE T02E1.5
gene id: 6239:CELE_T02E1.5
uniprot id: A5JYX5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expressed in the intestine and vulva.
messages: Lipid droplet
messages: May play a role in lipid droplet formation. May modulate triglyceride levels.
messages: Not expressed in embryos.
messages: Viable, but intestinal cells contain lipid droplets that are reduced in size and that contained a reduced amount of triglycerides as compared to wild-type.

6239:CELE W07A12.7
gene id: 6239:CELE_W07A12.7
uniprot id: Q9XVW1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Endoplasmic reticulum membrane
messages: Expressed in intestine, some sensory neurons in the head, body wall muscles and socket cells.
messages: Impaired acute acceleration of locomotion speed upon rapid increase in oxygen levels (from 0% to 5-20% oxygen). In double mutants for both rhy-1 and hif-1, normal increase in locomotion speed is restored.
messages: In L4 stage, expressed in vulva, ventral nerve cord, tail and at higher levels in hypodermis.
messages: Induced by hypoxia.
messages: Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1-independent manner (PubMed:16980385). Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis (PubMed:20011506, PubMed:20865124). Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation (PubMed:22405203). Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis (PubMed:16980385).

6239:CELE ZK546.1
gene id: 6239:CELE_ZK546.1
uniprot id: Q23529
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the hook family.
messages: Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus (PubMed:14697201). Required for dynein localization to the nuclear envelope (PubMed:14697201). Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair (PubMed:27956467).
messages: Does not contain a transmembrane domain.
messages: Expressed in the syncytial gonad, oocytes, and in all cells during the development of the early embryo.
messages: Homodimer (PubMed:14697201). Interacts with the dynein subunit dli-1 via its N-terminus (PubMed:14697201). May interact with microtubules (PubMed:14697201). Interacts with sut-2 (PubMed:19273536). Interacts (via C-terminus) with unc-84 (via C-terminus); the interaction is direct (PubMed:27956467).
messages: In contrast to isoform a and isoform d, isoform b and isoform c contain a potential transmembrane domain which may mediate insertion into the nuclear membrane.
messages: Induced by DNA-damage.
messages: Nucleus membrane
messages: RNAi-mediated knockdown results in a reduced number of viable progeny following incubation with the DNA cross-linking agent cisplatin.
messages: The large coiled coil domain is required for homodimerization.
messages: centrosome
messages: cytoskeleton

6239:CELE Y110A7A.4
gene id: 6239:CELE_Y110A7A.4
uniprot id: Q9N588
names: Similarity
messages: Belongs to the thymidylate synthase family.

6239:CELE C46H11.7
gene id: 6239:CELE_C46H11.7
uniprot id: Q9GYJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R53.2
gene id: 6239:CELE_R53.2
uniprot id: Q22018
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Catalyzes the conversion of dTMP to dTDP.

6239:CELE Y11D7A.14
gene id: 6239:CELE_Y11D7A.14
uniprot id: Q9XWR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE F09G2.5
gene id: 6239:CELE_F09G2.5
uniprot id: O17402
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F45B8.4
gene id: 6239:CELE_F45B8.4
uniprot id: G5EDE1
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the BDU neurons, the touch neurons, the VA, VB and VC motor neurons, two AVF interneurons and unidentified neurons of the retrovesicular ganglion (at protein level).
messages: Expressed in the Pn.aa neuroblasts and in each of their descendant cells, the Pn.aaa, Pn.aap, Pn.aaaa and Pn.aaap cells and the three differentiating neurons generated by each Pn.aa neuroblast; expression is transient, becoming undetectable shortly after the cells are generated in the larval L1 stage (at protein level) (PubMed:11923211). Expressed in the AVM and PVM touch neurons at the L1 larval stage until the early L2 stage (PubMed:9169852). Expressed in the VA and VB motor neurons and their immediate precursors in late L1 to early L2 stage (PubMed:9169852).
messages: May interact with transcription factor unc-3.
messages: Nucleus
messages: Perikaryon
messages: Transcription factor (PubMed:26096732). Plays a role in the determination of neuroblast cell fate and neuronal differentiation (PubMed:11923211, PubMed:26096732). Negatively modulates expression of several components of dense-core vesicles (DCVs), thereby, in a DCV membrane protein ida-1-dependent manner, regulating neurosecretion (PubMed:19343207). Negatively modulates the transcription of its own gene, the mechanosensory gene mec-3, and also other touch neuron-specific genes in the BDU neurons; required for coordinated movement (PubMed:9169852, PubMed:8770591, PubMed:26096732). Required to determine the identity of BDU sensory neurons in concert with transcription factor unc-86, regulating expression of a number of genes, including transcription factors ceh-14 and ahr-1, neuropeptides flp-10, nlp-1 and nlp-15, and tyramine receptor-encoding ser-2 (PubMed:26096732). Acts in concert with non-canonical WNT signaling to negatively modulate transcription of mec-3 gene in BDU neurons (PubMed:26096732). May act in concert with transcription factor unc-3 in motor neuron fate determination (PubMed:18817768). May play a role programmed cell death (PubMed:11923211).
messages: axon

6239:CELE F15A4.1
gene id: 6239:CELE_F15A4.1
uniprot id: O17816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F55F3.3
gene id: 6239:CELE_F55F3.3
uniprot id: Q9XUY5
uniprot id: V6CLW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size.

6239:CELE B0495.9
gene id: 6239:CELE_B0495.9
uniprot id: Q09218
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T01A4.1
gene id: 6239:CELE_T01A4.1
uniprot id: Q86GV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in head neurons, ventral cord and tail neurons, body wall muscle, hypodermis, somatic gonad and intestine (PubMed:16547101). Isoform d is expressed specifically in AIA interneurons (PubMed:21414922).
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:9188508). Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps (PubMed:18817734).
messages: Isoforms c: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922).
messages: Perikaryon
messages: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: axon
messages: dendrite

6239:CELE W02F12.5
gene id: 6239:CELE_W02F12.5
uniprot id: O45148
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

6239:CELE F12B6.2
gene id: 6239:CELE_F12B6.2
uniprot id: H2KZQ1
uniprot id: H2KZQ3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T12A2.7
gene id: 6239:CELE_T12A2.7
uniprot id: Q22417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

6239:CELE T18H9.2
gene id: 6239:CELE_T18H9.2
uniprot id: Q86NE0
names: Similarity
messages: Belongs to the peptidase A1 family.

6239:CELE H34C03.1
gene id: 6239:CELE_H34C03.1
uniprot id: Q9TYY7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in embryos.
messages: In the first mitotic division in embryos, required for mitotic spindle alignment and asymmetric cell division (PubMed:9649522, PubMed:17947426). Required for motor-driven chromosome movement and homolog searching within the nucleus, and subsequently ensures homologous chromosome pairing during the prophase stage of meiosis (PubMed:23671424).
messages: Mitochondrion
messages: Mitochondrion outer membrane

6239:CELE C27H6.8
gene id: 6239:CELE_C27H6.8
uniprot id: O17606
names: Similarity
messages: Belongs to the MYG1 family.

6239:CELE B0393.7
gene id: 6239:CELE_B0393.7
uniprot id: Q17496
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T19C3.9
gene id: 6239:CELE_T19C3.9
uniprot id: Q7YZH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE R04A9.5
gene id: 6239:CELE_R04A9.5
uniprot id: Q86DC2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0240.3
gene id: 6239:CELE_B0240.3
uniprot id: Q8I4N4
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed in sensory neurons including ASI, ASJ, ASK, AWB and AWC. Expressed in ASJ neurons in the dauer stage.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24015261). In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs (PubMed:19489741, PubMed:24015261). Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery (PubMed:1732156, PubMed:8893028, PubMed:21304598). Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response to NO-producing organisms like P.aeruginosa (PubMed:30014846). In ASI and ASJ sensory neurons, controls dauer formation and behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family (PubMed:11677050, PubMed:25303524). Required for the chemotaxis responses to non-volatile and volatile attractants mediated by the sensory neurons ASE and AWC respectively (PubMed:7828815, PubMed:10790386). Required in ASJ neurons for phototransduction downstream of G protein coupled-photoreceptor lite-1 (PubMed:20436480). Plays a role in the development of ASJ sensory neuron axons during late larval stages and in the maintenance of normal axon morphology in adults (PubMed:9486798). Required to maintain the expression of putative olfactory receptor str-2 in one of the two AWC neurons in adults (PubMed:10571181). Regulates, via the production of cGMP, lifespan (in some environmental conditions), sensitivity to oxidative stress and entry into quiescence triggered by satiety (PubMed:18316030, PubMed:19489741, PubMed:24015261). In AWB and AWC sensory neurons, mediates the recognition of food odors which subsequently allows for the detection of preferred food sources (PubMed:25009271).
messages: Perikaryon
messages: RNAi-mediated knockdown in AWB and AWC sensory neurons results in a defective preference between different food odors.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium
messages: dendrite

6239:CELE K02E7.10
gene id: 6239:CELE_K02E7.10
uniprot id: O17255
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE T18D3.2
gene id: 6239:CELE_T18D3.2
uniprot id: P41933
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Down-regulated by the cyanotoxin microcystin-LR.
messages: Expressed predominantly in the AWA neurons.
messages: Heterodimer with a partner that confers DNA binding capacity or a nuclear hormone receptor whose DNA binding it inhibits.
messages: May be expressed at all postembryonic stages.
messages: Nucleus
messages: Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity.
messages: Worms are defective in chemotaxis to the volatile odorants diacetyl and pyrazine and weakly defective in chemotaxis to 2,4,5-trimethylthiazole, but respond normally to the odorants benzaldehyde, butanone, and isoamyl alcohol.
messages: perinuclear region

6239:CELE Y25C1A.5
gene id: 6239:CELE_Y25C1A.5
uniprot id: Q9TYL9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

6239:CELE F52A8.5
gene id: 6239:CELE_F52A8.5
uniprot id: Q20634
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE F58G6.7
gene id: 6239:CELE_F58G6.7
uniprot id: Q95QD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6239:CELE C44C1.3
gene id: 6239:CELE_C44C1.3
uniprot id: P36608
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the recoverin family.
messages: Binds three calcium ions.
messages: Membrane
messages: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Can substitute for calmodulin and directly activate PDE, NO synthase, and calcineurin. Regulates associative learning and memory in a calcium dependent manner.

6239:CELE Y94H6A.8
gene id: 6239:CELE_Y94H6A.8
uniprot id: Q9N2W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

6239:CELE K12H6.3
gene id: 6239:CELE_K12H6.3
uniprot id: G5EEL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

6239:CELE R05F9.7
gene id: 6239:CELE_R05F9.7
uniprot id: Q21741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F32B6.3
gene id: 6239:CELE_F32B6.3
uniprot id: O45431
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

6239:CELE F16H9.2
gene id: 6239:CELE_F16H9.2
uniprot id: G5EGN8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Ligand-activated transcription factor (By similarity). Involved in lifespan extension in a manner dependent upon mitochondrial function (PubMed:24107417).
messages: Nucleus
messages: RNAi-mediated knockdown in a Rieske iron-sulfur protein isp-1 mutant background reduces life-span extension, causes a mild reduction in fertility, and reduces induction of expression of glutathione S-transferase gst-4.

6239:CELE C16C8.2
gene id: 6239:CELE_C16C8.2
uniprot id: P91060
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F56C4.3
gene id: 6239:CELE_F56C4.3
uniprot id: C1P638
uniprot id: C1P639
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZC412.3
gene id: 6239:CELE_ZC412.3
uniprot id: Q23307
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F56D1.2
gene id: 6239:CELE_F56D1.2
uniprot id: Q10128
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Component of a heterodimeric receptor complex composed of ilcr-1 and ilcr-2. The receptor complex interacts with actl-1 and ilc-17.1 with the interaction being mediated by ilcr-2.
messages: Expressed in most neurons, and in pharyngeal muscle.
messages: Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.

6239:CELE K01C8.6
gene id: 6239:CELE_K01C8.6
uniprot id: Q21083
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

6239:CELE Y66D12A.17
gene id: 6239:CELE_Y66D12A.17
uniprot id: Q95Q00
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the APC5 family.
messages: Double RNAi-mediated knockdown and/or mutagenesis with gfi-3 results in increased embryonic lethality and the production of one-cell arrested embryos.
messages: Expressed in head neurons, vulval precursor cells and in mature sperm stored in the spermatheca.
messages: Expressed in the developing germ line and throughout embryogenesis.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis (PubMed:17237515, PubMed:20944012). Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells (PubMed:20944014).
messages: The APC/C complex is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.

6239:CELE Y92H12A.4
gene id: 6239:CELE_Y92H12A.4
uniprot id: W6RQY9
names: Similarity
messages: Belongs to the Integrator subunit 3 family.

6239:CELE F21D12.5
gene id: 6239:CELE_F21D12.5
uniprot id: Q19677
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R12H7.3
gene id: 6239:CELE_R12H7.3
uniprot id: G5EC92
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE T05E12.4
gene id: 6239:CELE_T05E12.4
uniprot id: Q9XUR5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE K09A11.1
gene id: 6239:CELE_K09A11.1
uniprot id: Q21374
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE R02F11.3
gene id: 6239:CELE_R02F11.3
uniprot id: H2KZ89
uniprot id: Q5ZR77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE ZK131.1
gene id: 6239:CELE_ZK131.1
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C47D12.2
gene id: 6239:CELE_C47D12.2
uniprot id: Q18668
names: Similarity
messages: Belongs to the dymeclin family.

6239:CELE K10B2.1
gene id: 6239:CELE_K10B2.1
uniprot id: Q09990
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).
messages: Highest levels in embryos and adults, lowest levels in larvae. Maternal expression results in high zygotic levels.
messages: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

6239:CELE Y5H2B.6
gene id: 6239:CELE_Y5H2B.6
uniprot id: Q9N4Q4
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C16A3.10
gene id: 6239:CELE_C16A3.10
uniprot id: Q18040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion matrix

6239:CELE Y71F9AL.5
gene id: 6239:CELE_Y71F9AL.5
uniprot id: Q9N4H6
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

6239:CELE R03E1.4
gene id: 6239:CELE_R03E1.4
uniprot id: Q69YW8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE H06H21.3
gene id: 6239:CELE_H06H21.3
uniprot id: Q9TXU7
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

6239:CELE F13G3.1
gene id: 6239:CELE_F13G3.1
uniprot id: Q19418
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed in pharyngeal epithelium/arcade, which connects the pharynx to the mouth.
messages: RNAi-mediated knockdown causes an increase in fat-5 gene expression in the pharynx (PubMed:16777607). Pharynx unattached (Pun) phenotype (PubMed:16777607).
messages: Transcription factor (PubMed:16777607). Represses gene expression, probably via binding to DNA consensus sequence 5'-[AT][CT]TTCC[AC][AG]-3' in promoter regions (PubMed:16777607). May play a role in pharynx morphogenesis (PubMed:16777607).

6239:CELE ZK652.3
gene id: 6239:CELE_ZK652.3
uniprot id: P34661
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the UFM1 family.
messages: Expressed in the intestine and head neurons.
messages: Interacts with odr-8; leading to deufmylation.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity). The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc-1, and probably the ufm-1-ligase E3 enzyme ufl-1 (PubMed:23449979).

6239:CELE Y48G8AL.5
gene id: 6239:CELE_Y48G8AL.5
uniprot id: Q9BL15
uniprot id: V6CLJ9
uniprot id: V6CLP2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C28C12.9
gene id: 6239:CELE_C28C12.9
uniprot id: H2KYN3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE T12A2.11
gene id: 6239:CELE_T12A2.11
uniprot id: P54127
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE CTEL55X.1
gene id: 6239:CELE_CTEL55X.1
uniprot id: A4F305
uniprot id: H2KY55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

6239:CELE F10G2.3
gene id: 6239:CELE_F10G2.3
uniprot id: Q22955
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE H24K24.4
gene id: 6239:CELE_H24K24.4
uniprot id: A0A0K3AVN7
uniprot id: A0A0K3AXZ0
uniprot id: Q9N5L0
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C17E4.6
gene id: 6239:CELE_C17E4.6
uniprot id: Q93230
names: Similarity
messages: Belongs to the VPS72/YL1 family.

6239:CELE C15H11.7
gene id: 6239:CELE_C15H11.7
uniprot id: O17586
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE Y71G12B.23
gene id: 6239:CELE_Y71G12B.23
uniprot id: C0VXV9
uniprot id: H2KZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE C27B7.7
gene id: 6239:CELE_C27B7.7
uniprot id: Q18245
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T03D3.3
gene id: 6239:CELE_T03D3.3
uniprot id: O16980
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C41C4.8
gene id: 6239:CELE_C41C4.8
uniprot id: P54812
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates (PubMed:18782221, PubMed:22768338). However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner (PubMed:18782221). Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains (PubMed:19545544). Involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:17825049, PubMed:21317884, PubMed:22768338, PubMed:25652260). This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:17825049, PubMed:21317884, PubMed:22768338, PubMed:25652260). Together with udf-2 and chn-1, regulates myosin assembly in body wall muscles by targeting myosin chaperone unc-45 for proteasomal degradation (PubMed:17369820). During oocyte meiosis and together with cdc-48.1, required for chromosome condensation at the diakinesis phase in prophase I and for progression of metaphase I (PubMed:17512499). During the first embryonic cell division, regulates DNA replication and thus chromosome segregation and decondensation, and nuclear envelope re-assembly (PubMed:18097415, PubMed:18728180, PubMed:21981920, PubMed:26842564). In S phase and in association with ufd-1, npl-4.1 and/or npl-4.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:21981920, PubMed:26842564). Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564). During the first embryonic cell divisions and together with cdc-48.1, regulates the re-asse…
messages: Belongs to the AAA ATPase family. CDC48 subfamily.
messages: Cytoplasm
messages: Expressed in body wall muscles.
messages: Homohexamer; oligomerization is ATP-independent (PubMed:18782221). Forms a ring-shaped particle of 18.3 nm diameter, that displays 6-fold radial symmetry (By similarity). Interacts with cdc-48.1 and thus may form heterohexamers (PubMed:16647269, PubMed:17369820). Forms a complex composed of ubxn-3, cdc-48.1 and/or cdc-48.2 and substrate cdt-1 (PubMed:26842564). Interacts (via N-terminus) with ubxn-3 (PubMed:20977550). Interacts (via N-terminus) with atx-3 (via RRDR motif) (PubMed:19545544, PubMed:21317884). Interacts (via N-terminus) with ubxn-5 (PubMed:19545544). Interacts with ufd-1 (PubMed:16647269). Interacts (via DDDLYN motif) with ufd-2 (PubMed:21317884, PubMed:17369820). Interacts (via N-terminus) with ubxn-1 (PubMed:16647269, PubMed:20977550). Interacts (via N-terminus) with ubxn-2 (PubMed:23649807, PubMed:20977550). Interacts (via N-terminus) with ubxn-4 (PubMed:20977550). Interacts with ubxn-6 (PubMed:20977550).
messages: Induced upon ER stress. Repressed by starvation and oxidative stress.
messages: Predominantly expressed in embryos (at protein level) (PubMed:16701565). Expression transiently increases at the L2 larval stage (PubMed:17369820).
messages: RNAi-mediated knockdown causes embryonic lethality in 30-50 percent of embryos (PubMed:15716356). RNAi-mediated knockdown prevents ubxn-2 nuclear localization in the 2-cell embryo (PubMed:23649807). RNAi-mediated knockdown in an unc-45 (m94) mutant background, does not restore motility (PubMed:17369820). Simultaneous RNAi-mediated knockdown of cdc-48.1 causes embryonic lethality (PubMed:15716356, PubMed:16647269, PubMed:18097415, PubMed:18728180, PubMed:26842564). Defects in oocyte meiosis I progression (PubMed:17512499). Defects in embryo S phase DNA replication causing delays in cell cycle progression (PubMed:17512499, PubMed:18097415, PubMed:18728180, PubMed:21981920). At the end of mitosis, impairs chromatin decondensation and nuclear envelope re-assembly (PubMed:18728180, PubMed:18097415). In addition, abnormal accumulation of air-2 on mitotic chromatin and impaired air-2 activation (PubMed:18097415). Does not affect ER transition into sheet-like structures at the onset of embryonic mitosis (PubMed:15716356). Simultaneous RNAi-mediated knockdown of cdc-48.2 in young adults decreases lifespan, induces the unfolded protein response, increases overall levels of polyubiquitinated proteins, and impairs the degradation of misfolded ER proteins (PubMed:16647269, PubMed:17825049, PubMed:17369820, PubMed:21317884, PubMed:22768338). Causes defects in germline development (PubMed:20977550).
messages: The first ATP-binding region has low ATPase activity (By similarity). The second ATP-binding region is responsible for ATPase activity (By similarity). ATP binding to the first ATP-binding region induces intrinsic activity of the second ATP-binding region (By similarity). While ATP binding to the first ATP-binding region appears to prevent ATP hydrolysis by the second ATP-binding region, ADP-binding to first region promotes the coordinate and cooperative ATPase cycle of the second ATP-binding region (By similarity). ATP binding to the first ATP-binding region induces a conformational change, promoting the rotation of the first ATP-binding region relative to the second ATP-binding region in the hexamer (By similarity). Inhibited by N-ethylmaleimide (NEM) (PubMed:18782221).

6239:CELE F18A1.8
gene id: 6239:CELE_F18A1.8
uniprot id: Q19541
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the pid-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least pid-1, tofu-6, ife-3, pid-3, and erh-2, which is required for the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the complex interacts with pid-3; the interaction is direct (PubMed:31216475, PubMed:31147388). Within the complex interacts with erh-2 (PubMed:31216475, PubMed:31147388). Within the complex interacts with tofu-6 (PubMed:31216475).
messages: Component of the pid-1 variant of the PETISCO complex which is required for the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the complex acts as an adapter which binds to the complex via erh-2 (PubMed:31147388). Involved in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing (PubMed:24696453, PubMed:33231880). Plays a role in small RNA-directed transgenerational epigenetic inheritance (PubMed:33231880).
messages: Cytoplasm
messages: Expressed from early embryogenesis (at protein level).
messages: Expressed predominantly in the germline (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown results in defective activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388). RNAi-mediated knockdown disrupts the localization of tofu-6 to the perinuclear region of the germline (PubMed:31216475). RNAi-mediated knockdown does not cause chromosome segregation and cell division defects in early embryos (PubMed:31216475).
messages: perinuclear region

6239:CELE M03F8.2
gene id: 6239:CELE_M03F8.2
uniprot id: Q8MXJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Golgi apparatus membrane
messages: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).

6239:CELE W01A11.6
gene id: 6239:CELE_W01A11.6
uniprot id: Q23069
names: Similarity
messages: In the N-terminal section; belongs to the MoaB/Mog family.

6239:CELE F22F1.1
gene id: 6239:CELE_F22F1.1
uniprot id: Q19743
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
messages: Nucleus

6239:CELE T06A1.1
gene id: 6239:CELE_T06A1.1
uniprot id: O61930
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C53B7.5
gene id: 6239:CELE_C53B7.5
uniprot id: Q18807
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway.
messages: Belongs to the nematode receptor-like protein str family.
messages: Defective response to diacetyl with wild-type response exhibited to other ketones and odorants sensed by AWA.
messages: Expressed in AWA olfactory neurons at the L3 larval stage in males and hermaphrodites, but expressed decreases in males from the L4 stage to adulthood.
messages: Induced upon exposure to the volatile odorant diacetyl.
messages: Interacts with odr-4.
messages: Strongly expressed in the sensory cilia of AWA olfactory neurons, and at low levels in the CEP neurons.
messages: cilium membrane

6239:CELE M01F1.7
gene id: 6239:CELE_M01F1.7
uniprot id: G5EED9
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

6239:CELE F36H2.2
gene id: 6239:CELE_F36H2.2
uniprot id: F5GUE6
uniprot id: Q93690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE T04B2.6
gene id: 6239:CELE_T04B2.6
uniprot id: D3KFT5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE C50F7.4
gene id: 6239:CELE_C50F7.4
uniprot id: P53589
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

6239:CELE K07H8.2
gene id: 6239:CELE_K07H8.2
uniprot id: O45182
uniprot id: Q965K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

6239:CELE ZK1193.1
gene id: 6239:CELE_ZK1193.1
uniprot id: P18835
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE F28B12.3
gene id: 6239:CELE_F28B12.3
uniprot id: Q19848
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Autophosphorylates in vitro.
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
messages: Embryonically lethal. Homozygous animals produced by heterozygous hermaphrodites overcome this through maternal contribution. In these animals, defects in the formation of the vulva, uterus, and uterine seam cells and in development and maintenance of the somatic gonad and thus the germ line appear in the early L3 larval stage. Adults are sterile. Cells display mitotic defects, including impaired nuclear envelope formation and baf-1 delocalization.
messages: Nucleus
messages: Present in germ cells at all stages of progression from the mitotic zone to mature oocytes, but not in maturing spermatids (at the protein level). Expressed in the ventral nerve cord and vulva cells.
messages: Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage.

6239:CELE F43G9.1
gene id: 6239:CELE_F43G9.1
uniprot id: Q93714
names: Cofactor
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.
messages: Mitochondrion
messages: RNAi-mediated knockdown causes accumulation of citrate, leading to induction of the citrate-induced mitochondrial unfolded protein response (mtUPR).

6239:CELE C06E7.6
gene id: 6239:CELE_C06E7.6
uniprot id: P54218
names: Function
messages: Required for spermiogenesis.

6239:CELE T08B1.2
gene id: 6239:CELE_T08B1.2
uniprot id: K8ERV5
uniprot id: O44556
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

6239:CELE Y54E10BR.7
gene id: 6239:CELE_Y54E10BR.7
uniprot id: Q9N3C7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K02H11.4
gene id: 6239:CELE_K02H11.4
uniprot id: O61984
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C03G5.1
gene id: 6239:CELE_C03G5.1
uniprot id: Q09508
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

6239:KEF34 p03
gene id: 6239:KEF34_p03
uniprot id: G5EGS6
uniprot id: P24894
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE C33G8.6
gene id: 6239:CELE_C33G8.6
uniprot id: O76828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F47G4.3
gene id: 6239:CELE_F47G4.3
uniprot id: Q9XTS4
names: Similarity
names: Subunit
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Homodimer.

6239:CELE C07A9.1
gene id: 6239:CELE_C07A9.1
uniprot id: P34312
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T26C12.1
gene id: 6239:CELE_T26C12.1
uniprot id: O61856
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner.
messages: Endoplasmic reticulum membrane

6239:CELE Y57A10B.3
gene id: 6239:CELE_Y57A10B.3
uniprot id: Q9XWH8
names: Subcellular Location Annotation
messages: Secreted

6239:CELE W02D3.7
gene id: 6239:CELE_W02D3.7
uniprot id: O01814
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6239:CELE F23B2.12
gene id: 6239:CELE_F23B2.12
uniprot id: G5EFJ8
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE Y48C3A.10
gene id: 6239:CELE_Y48C3A.10
uniprot id: Q9NAG2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

6239:CELE C06A5.11
gene id: 6239:CELE_C06A5.11
uniprot id: Q95Q89
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the sirtuin family. Class IV subfamily.
messages: Binds 1 zinc ion per subunit.
messages: NAD-dependent protein deacetylase.

6239:CELE T06F4.2
gene id: 6239:CELE_T06F4.2
uniprot id: H2L0J1
uniprot id: Q95ZP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

6239:CELE Y73F8A.30
gene id: 6239:CELE_Y73F8A.30
uniprot id: H2KML8
uniprot id: H2KML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C52A10.1
gene id: 6239:CELE_C52A10.1
uniprot id: Q95YC4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE K03E6.1
gene id: 6239:CELE_K03E6.1
uniprot id: Q21192
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in a restricted set of neurons, and epithelial cells of the uterus and the excretory system, late in embryogenesis at about 300 minutes of development (PubMed:10068647). Expression in neurons continues throughout adulthood (PubMed:10068647). Expressed asymmetrically, only in the left neuron (ASEL), of the ASER and ASEL chemosensory pair (PubMed:10068647). Expressed in the interneuron PVT during embryogenesis (PubMed:12490565).
messages: Nucleus
messages: Transcription factor (By similarity). Required for the terminal differentiation of sensory- and motor-neurons, especially GABAergic neurons, and for morphological aspects of uterine development (PubMed:10068647). Plays a role in the cell-type-specific regulation of glutamic acid decarboxylase unc-25 (PubMed:10068647). Involved in promoting sleep-like behavioral quiescence, acting by modulating expression of transcription factor aptf-1 in the single sleep-active ring interneuron RIS (PubMed:26949257). Plays a role in regulation of RIS differentiation (PubMed:14568548). Required for the functional asymmetry of the ASER and ASEL chemosensory neuron pair, conferring the ability to discriminate sodium from chloride, perhaps by modulating expression of receptor-type guanylate cyclases, such as gcy-5 (PubMed:11287956, PubMed:21555395). Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein ceh-14, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT (PubMed:12490565). May play a role in the functions of the excretory gland cell (PubMed:10068647).

6239:CELE Y41D4B.10
gene id: 6239:CELE_Y41D4B.10
uniprot id: Q95Y10
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

6239:CELE C01A2.5
gene id: 6239:CELE_C01A2.5
uniprot id: O02209
names: Similarity
messages: Belongs to the rtf2 family.

6239:CELE C09E9.1
gene id: 6239:CELE_C09E9.1
uniprot id: Q93196
names: Similarity
messages: Belongs to the TUSC2 family.

6239:CELE F08C6.7
gene id: 6239:CELE_F08C6.7
uniprot id: Q19203
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Disorganised A and I bands in body-wall muscle structure (PubMed:7348600). Defective extension of body wall muscle connections or arms towards the ventral nerve cord (PubMed:27123983). Double knockout with madd-3 results in severe muscle arm extension defects (PubMed:27123983).
messages: Expressed in embryos from 1.5- to 2-fold stage in myofibrils. In larvae and adults, it is expressed in body wall muscle, and in addition, anal depressor muscle and vulval muscles. More specifically it is found in the thick filaments of muscle fibers.
messages: Interacts with hum-6, mep-1, myo-3, unc-96 and unc-97/PINCH.
messages: Nucleus
messages: Probable transcription factor required for muscle structure (PubMed:12808046, PubMed:7348600). Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression (PubMed:12808046). Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role (PubMed:17158957). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).
messages: The N-terminal part (1-106) mediates the nuclear localization, while the fourth zinc finger is required for the localization to M-lines and dense bodies.

6239:CELE R11G11.1
gene id: 6239:CELE_R11G11.1
uniprot id: O16961
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK945.9
gene id: 6239:CELE_ZK945.9
uniprot id: Q09624
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the polycystin family.
messages: Exclusively expressed in a subset of three categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons.
messages: First expressed during L4 and peaks in the adult male.
messages: Interacts (via PLAT domain) with atp-2 (via N-terminus) and with kin-10 (via C-terminus). Interacts (via C-terminus) with isoform a of stam-1/pqn-19 (via C-terminus).
messages: Membrane
messages: Required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as pkd-2 and atp-2 in response behavior. May be required for ciliary targeting of pkd-2.
messages: Worms lacking lov-1 exhibit defects in two aspects of male mating behavior: response to hermaphrodite contact and vulva location.
messages: cilium

6239:CELE F09E5.8
gene id: 6239:CELE_F09E5.8
uniprot id: P52057
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

6239:CELE F42G8.11
gene id: 6239:CELE_F42G8.11
uniprot id: O44511
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

6239:CELE R07B1.4
gene id: 6239:CELE_R07B1.4
uniprot id: Q09607
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE F59F4.1
gene id: 6239:CELE_F59F4.1
uniprot id: Q93839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

6239:CELE C06A6.5
gene id: 6239:CELE_C06A6.5
uniprot id: Q17688
names: Domain
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen
messages: The thioredoxin domain lacks the 2 redox-active Cys. This strongly suggests that it lacks thioredoxin activity.

6239:CELE T01H10.1
gene id: 6239:CELE_T01H10.1
uniprot id: Q22079
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C45E1.1
gene id: 6239:CELE_C45E1.1
uniprot id: O44960
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y39H10A.7
gene id: 6239:CELE_Y39H10A.7
uniprot id: Q9N3Z3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
messages: Cytoplasm
messages: Expressed in the germline.
messages: Highly expressed in the embryo.
messages: Nucleus
messages: RNAi-mediated knockdown leads to premature cell-cycle reentry of the Z2/Z3 primordial germ cells in L1 stage larvae (PubMed:26073019). RNAi-mediated knockdown and DNA damage induced by the ribonucleotide reductase inhibitor hydroxyurea in germ cells results in impaired DNA repair, but does allow for nuclear division (PubMed:27956467). In the proliferative zone of these germ cells, nuclei do not arrest following DNA damage, but prematurely divide and are smaller compared to wild-type (PubMed:27956467).
messages: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:15326393). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:15326393). Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells (PubMed:15326393, PubMed:27956467). Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae (PubMed:26073019). Essential for embryogenesis (PubMed:15326393).
messages: perinuclear region

6239:CELE T07A9.5
gene id: 6239:CELE_T07A9.5
uniprot id: O44406
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the ERI/DICER complex at least composed of dcr-1, rrf-3 and eri-1.
messages: Cytoplasm
messages: Expressed in the somatic developing gonads and in a subset of neurons. In adults, it is specifically expressed in neurons and in spermatheca.
messages: Interacts with pir-1.
messages: RNA exonuclease that acts as a negative regulator of RNA interference (RNAi) (PubMed:14961122). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs) (PubMed:14961122). Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable).

6239:CELE K07F5.15
gene id: 6239:CELE_K07F5.15
uniprot id: I7J4C6
names: Similarity
messages: Belongs to the UPF0390 family.

6239:CELE F01F1.8
gene id: 6239:CELE_F01F1.8
uniprot id: G8JY43
uniprot id: P46550
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

6239:CELE T11A5.7
gene id: 6239:CELE_T11A5.7
uniprot id: Q5WRN5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK1127.10
gene id: 6239:CELE_ZK1127.10
uniprot id: P55216
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the trans-sulfuration enzymes family.
messages: Cytoplasm

6239:CELE C42C1.11
gene id: 6239:CELE_C42C1.11
uniprot id: G5EFT4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase which preferentially removes N-terminal Arg and Lys residues from peptides and proteins.
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Despite its similarity to leukotriene hydrolases, AP-1 does not have leukotriene hydrolase activity. One of the mammalian leukotriene binding sites, 'Tyr-378', is replaced by a Phe residue in AP-1.

6239:CELE F58G1.3
gene id: 6239:CELE_F58G1.3
uniprot id: O62272
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE Y69A2AR.2
gene id: 6239:CELE_Y69A2AR.2
uniprot id: Q9GSX9
uniprot id: U4PF95
uniprot id: U4PS45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the synembryn family.
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein coupled receptors. While it acts as a GEF for goa-1, it has no GEF activity toward gpa-16. In addition to its GEF activity, it is required for cortical subcellular localization of G-alpha proteins such as gpa-16. Also required for the interaction of goa-1 and gpr-1/2, suggesting that it may act by generating G-alpha proteins free from G-beta-gamma subunits, enabling gpr-1/2 to mediate asymmetric cell division.
messages: Interacts with GDP-bound G-alpha proteins goa-1 and gpa-16. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
messages: Present throughout the nervous system in juveniles and adults (at protein level).
messages: cell cortex

6239:CELE ZK770.3
gene id: 6239:CELE_ZK770.3
uniprot id: O01634
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expressed in hyp8-11 tail tip cells during the L4 larval stage.
messages: RNAi-mediated knockdown causes defective oocyte transit through the spermatheca. Calcium oscillations triggered during ovulation are random resulting in uncoordinated spermatheca constrictions. Oocytes enter the spermatheca normally but change direction several times before returning into the gonad or proceeding into the uterus. RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209).
messages: Structural component of the gap junctions (By similarity). Plays a role in oocyte directional transit in the spermatheca during ovulation by facilitating the directional propagation of the calcium signal in the spermatheca (PubMed:23671426). Plays a role in male tail tip morphogenesis (PubMed:21408209).
messages: gap junction

6239:CELE T09F3.3
gene id: 6239:CELE_T09F3.3
uniprot id: P04970
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in C.elegans.

6239:CELE F58G4.1
gene id: 6239:CELE_F58G4.1
uniprot id: Q21000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

6239:CELE F35G2.2
gene id: 6239:CELE_F35G2.2
uniprot id: Q20062
names: Similarity
messages: Belongs to the isochorismatase family.

6239:CELE T01H10.5
gene id: 6239:CELE_T01H10.5
uniprot id: Q22083
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y73F8A.1
gene id: 6239:CELE_Y73F8A.1
uniprot id: Q9U1S7
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Exclusively expressed in a subset of 3 categories of adult male sensory neurons: ray neurons, hook neurons and head cephalic (CEM) neurons (PubMed:10517638, PubMed:11553327, PubMed:12411744, PubMed:15563610, PubMed:16943275, PubMed:16481400, PubMed:31264582). Expressed in the male tail (PubMed:26150102, PubMed:28745435).
messages: First expressed during L4 and peaks in the adult male.
messages: Functions as a calcium permeable cation channel (PubMed:15862350). Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location (PubMed:11553327, PubMed:12411744, PubMed:15862350, PubMed:15753033, PubMed:18037411, PubMed:28745435). Acts in the same pathway as lov-1 and atp-2 in response behavior (PubMed:11553327).
messages: Perikaryon
messages: Phosphorylated. CK2 (kin-3 and kin-10) and calcineurin act antagonistically to regulate the phosphorylation state.
messages: The transmembrane domains are sufficient for localization in the cilium. The cytoplasmic tails are necessary for localization in cell bodies and anchoring at the ciliary base. Cytoplasmic tails also regulate sensory function.
messages: Worms exhibit defects in 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location.
messages: axon
messages: cilium
messages: cilium membrane
messages: dendrite

6239:CELE F48F5.5
gene id: 6239:CELE_F48F5.5
uniprot id: G5EEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.

6239:CELE K07H8.3
gene id: 6239:CELE_K07H8.3
uniprot id: O61219
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.
messages: Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (By similarity). Plays a role in regulating larval development, metabolism and longevity. Functions downstream or alongside daf-3, daf-12 and daf-16 in the dauer formation pathway. Functions upstream of daf-15 to enable animal development.
messages: Component of the N-terminal acetyltransferase A (NatA) complex.
messages: Expressed from larval stage L1 to adulthood.
messages: Expressed in head and tail hypodermal cells, hypodermal seam cells, pharynx, intestine and head and tail neurons.
messages: The majority of animals die within five days following dauer-like arrest, but surviving animals grow to the L4 larval developmental stage or adulthood. Animals display a dauer-like phenotype in response to pheromone and starvation, form dauer alae and have a constricted pharynx. Unlike dauer defective animals, these animals are not temperature sensitive and do not complete dauer morphogenesis. Animals have an increased propensity to accumulate fat. RNAi-mediated knock-down also induces a dauer-like phenotype and fat accumulation. However, knock-down does not influence the lifespan of animals.

6239:CELE C15H9.4
gene id: 6239:CELE_C15H9.4
uniprot id: Q18025
names: Similarity
messages: Belongs to the TEX28 family.

6239:CELE C37H5.2
gene id: 6239:CELE_C37H5.2
uniprot id: P91143
names: Similarity
messages: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

6239:CELE K08D10.8
gene id: 6239:CELE_K08D10.8
uniprot id: Q21318
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE K10D2.7
gene id: 6239:CELE_K10D2.7
uniprot id: Q09412
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

6239:CELE ZK1058.3
gene id: 6239:CELE_ZK1058.3
uniprot id: Q27536
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

6239:CELE R11A8.7
gene id: 6239:CELE_R11A8.7
uniprot id: Q21920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mask family.
messages: Cytoplasm

6239:CELE Y51A2D.15
gene id: 6239:CELE_Y51A2D.15
uniprot id: F3Y5P4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC88 family.
messages: Broadly expressed during embryogenesis with high expression at the presumptive nose during the 1.5-fold stage of embryogenesis. Expressed in AWB sensory neurons in larvae and in PHA/PHB tail neurons at the L1 stage of larval development.
messages: Embryonic lethal with few malformed larvae that develop to the L1 stage of larval development.
messages: Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10.
messages: The C-terminal domain is required for localization to the cilium basal body and role in ciliogenesis.
messages: centriole
messages: cilium basal body

6239:CELE F52C9.8
gene id: 6239:CELE_F52C9.8
uniprot id: Q10124
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the REXO1/REXO3 family.
messages: Expressed in the excretory canal, vulval cells, the intestine and in head and tail neurons including ASH, RIC and AIZ neurons.
messages: Nucleus
messages: Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins (PubMed:12486229). It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration (PubMed:12486229). Regulates gene expression in neurons (PubMed:22870397).
messages: The Gln/Pro-rich N-terminus and the Arg/Asp/Glu/Lys-rich charged domain are critical in protecting glutamatergic ASH sensory neurons from degeneration. ASH neurons expressing isoforms lacking these domains show progressive degeneration.

6239:CELE Y45G12C.7
gene id: 6239:CELE_Y45G12C.7
uniprot id: G5EF74
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE C45H4.17
gene id: 6239:CELE_C45H4.17
uniprot id: A0A0M7RF95
uniprot id: O44706
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F15D3.1
gene id: 6239:CELE_F15D3.1
uniprot id: Q9TW65
uniprot id: V6CJD7
uniprot id: V6CKJ6
uniprot id: V6CLR8
uniprot id: V6CLV8
uniprot id: V6CLW7
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the dystrophin glycoprotein complex (DGC). Interacts with dyb-1 and stn-1 to form the DGC. Interacts with stn-2.
messages: Expressed in body wall, head, pharyngeal and vulval muscles, from late embryogenesis to adulthood (at protein level).
messages: Mutants display a phenotype of hyperactive locomotion and are hypersensitive to the acetylcholinesterase inhibitor aldicarb and are defective in maintaining neuronal positioning. Dys-1 and hlh-1 double mutants synergistically exhibit progressive myopathy.
messages: Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.
messages: cytoskeleton
messages: sarcolemma

6239:CELE T13H10.2
gene id: 6239:CELE_T13H10.2
uniprot id: Q7YWT8
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y59C2A.1
gene id: 6239:CELE_Y59C2A.1
uniprot id: Q9TZC6
names: Similarity
messages: Belongs to the peptidase M14 family.

6239:CELE Y45G12B.3
gene id: 6239:CELE_Y45G12B.3
uniprot id: Q9N4Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L2HGDH family.
messages: Mitochondrion

6239:CELE M57.2
gene id: 6239:CELE_M57.2
uniprot id: Q9TYY0
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

6239:CELE Y56A3A.21
gene id: 6239:CELE_Y56A3A.21
uniprot id: Q9U238
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

6239:CELE C06G8.3
gene id: 6239:CELE_C06G8.3
uniprot id: A7LPH3
uniprot id: Q6BEU0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC434.4
gene id: 6239:CELE_ZC434.4
uniprot id: Q23314
names: Similarity
messages: Belongs to the RRP7 family.

6239:CELE C13F10.2
gene id: 6239:CELE_C13F10.2
uniprot id: O01488
names: Similarity
messages: Belongs to the KXD1 family.

6239:CELE B0285.1
gene id: 6239:CELE_B0285.1
uniprot id: P46551
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates 'Ser-2' in the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. Required for normal reproduction.
messages: Nucleus
messages: Phosphorylation of 'Ser-2' of the RNA polymerase II C-terminal domain is undetectable in primordial germ cells and reduced by 60% in embryonic somatic nuclei. RNAi treatment causes sterility.

6239:CELE ZK177.5
gene id: 6239:CELE_ZK177.5
uniprot id: Q09660
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE ZK858.6
gene id: 6239:CELE_ZK858.6
uniprot id: B3WFW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

6239:CELE F18C5.1
gene id: 6239:CELE_F18C5.1
uniprot id: Q19549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C39F7.2
gene id: 6239:CELE_C39F7.2
uniprot id: B1GRL4
uniprot id: Q9UAQ3
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE F59C6.12
gene id: 6239:CELE_F59C6.12
uniprot id: Q564X7
names: Similarity
messages: Belongs to the UPF0598 family.

6239:CELE F58F6.2
gene id: 6239:CELE_F58F6.2
uniprot id: O44173
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE H23N18.4
gene id: 6239:CELE_H23N18.4
uniprot id: Q9TXZ3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F56A11.1
gene id: 6239:CELE_F56A11.1
uniprot id: O44518
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYFIP family.
messages: Cytoplasm
messages: Embryonic lethal with cells differentiating, but failing to become organized (PubMed:11877381). The external hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). In one study, animals are viable and there is defective extension of body wall muscle connections or arms towards the ventral nerve cord (PubMed:27123983). In this same study, double knockout with madd-3 results in severe muscle arm extension defects (PubMed:27123983). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448).
messages: Interacts with gex-3.
messages: Required for initial steps of body morphogenesis (PubMed:11877381). May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).

6239:CELE T20G5.2
gene id: 6239:CELE_T20G5.2
uniprot id: P34575
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Mitochondrion matrix

6239:CELE F55H2.5
gene id: 6239:CELE_F55H2.5
uniprot id: P34465
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 2 heme b groups non-covalently.
messages: Membrane
messages: Putative transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles.

6239:CELE ZK1127.3
gene id: 6239:CELE_ZK1127.3
uniprot id: Q23403
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

6239:CELE C05D11.9
gene id: 6239:CELE_C05D11.9
uniprot id: Q11188
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of nuclear RNase P and RNase MRP ribonucleoproteins (By similarity). Several subunits of RNase P are also part of the RNase MRP complex (By similarity).
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (By similarity). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (By similarity).
messages: nucleolus

6239:CELE F58A4.5
gene id: 6239:CELE_F58A4.5
uniprot id: P34472
names: Subcellular Location Annotation
messages: Secreted

6239:CELE K10C9.3
gene id: 6239:CELE_K10C9.3
uniprot id: O61887
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RNase T2 family.
messages: Expressed from embryogenesis to adulthood.
messages: Expressed in the pharynx, hypodermis, muscle cells, sheath cells, intestinal cells, the vulva and tail regions.
messages: Lysosome
messages: Probable endoribonuclease involved in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes.

6239:CELE C08C3.3
gene id: 6239:CELE_C08C3.3
uniprot id: P10038
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the Antp homeobox family.
messages: Defective QL neuroblast daughter cell migration (PubMed:8898225). Lin-39 and mab-5 double mutants have reduced sex myoblast specific expression of sem-2 in the developing mesoderm (PubMed:21307099).
messages: Expressed asymmetrically in the QL neuroblast.
messages: Nucleus
messages: Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration (PubMed:8898225, PubMed:23784779). During postembryonic development, required for posterior-specific pattern formation (PubMed:2903796). Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation (PubMed:2903796, PubMed:21307099).

6239:CELE T28F2.8
gene id: 6239:CELE_T28F2.8
uniprot id: Q7Z152
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C25A6.1
gene id: 6239:CELE_C25A6.1
uniprot id: Q4R171
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F32A5.5
gene id: 6239:CELE_F32A5.5
uniprot id: Q19949
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE H41C03.3
gene id: 6239:CELE_H41C03.3
uniprot id: O76634
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE ZK993.1
gene id: 6239:CELE_ZK993.1
uniprot id: Q9N4L2
uniprot id: V6CJ20
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T07C4.2
gene id: 6239:CELE_T07C4.2
uniprot id: Q22292
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed during morphogenesis in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells (PubMed:15066124, PubMed:15102704). First detected in the Ea and Ep cells until the 24 cell stage (PubMed:15066124, PubMed:15102704). At the 24 cell stage detected in 5 cells including AB descendant cells and also the Ca and Cp cells (PubMed:15066124). At the 200 cell stage, detected in two pairs of MS descendant cells (PubMed:15066124). Thereafter detected in a subset of cells at each stage up to approximately the 400 cell stage, becoming undetectable just before morphogenesis (PubMed:15066124). During morphogenesis detected in the hypodermis, body-wall muscle, intestine and dorsal, lateral and ventral hypodermal cells up until early L1 larval stage (PubMed:15066124, PubMed:15102704).
messages: Nucleus
messages: RNAi-mediated knockdown causes about 5% embryonic lethality with 1-10% of hatching larvae displaying posterior morphological defects (PubMed:15102704, PubMed:15892873). Defective intercalation of dorsal hypodermis (PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-9 causes at least 48% of embryos to fail to hatch and those that do display severe morphological defects and die as larvae (PubMed:15892873, PubMed:15102704). Simultaneous RNAi-mediated knockdown of tbx-9 abolishes muscle expression of vab-7 (PubMed:15102704).
messages: Transcription factor (By similarity). Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle (PubMed:15066124, PubMed:15102704). Involved in regulating expression of vab-7 (PubMed:15102704). Appears to have partially redundant function to tbx-9 (PubMed:15066124).

6239:CELE C05B5.3
gene id: 6239:CELE_C05B5.3
uniprot id: P34291
names: Tissue Specificity
messages: Expressed in the pharyngeal glands.

6239:CELE B0495.4
gene id: 6239:CELE_B0495.4
uniprot id: Q8T5S1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Biphasic expression pattern with high expression in the L1 and L2 larval stages and gradual decrease through adult stages.
messages: Expressed uniformly in the intestinal epithelial cells.
messages: Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept-1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway.
messages: RNAi-mediated knockdown of the protein causes worms to become extremely lean and transparent. Slower progression through the larval stages, in particular the L1 and L2 stages. Increase in average life span, decreased brood size and loss of fat storage granules in the intestine leading to decreased opacity. Reduced rate of pharyngeal pumping, reduced size of proton pulses inside the cells, increased intracellular acidification, reduced uptake of fatty acids, and doubling of the defecation period.

6239:CELE C37H5.13
gene id: 6239:CELE_C37H5.13
uniprot id: Q95Q68
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE ZC334.10
gene id: 6239:CELE_ZC334.10
uniprot id: Q7JKM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE R08F11.5
gene id: 6239:CELE_R08F11.5
uniprot id: O01888
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK1290.12
gene id: 6239:CELE_ZK1290.12
uniprot id: Q94128
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE Y39B6A.27
gene id: 6239:CELE_Y39B6A.27
uniprot id: Q8MYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE Y19D10A.5
gene id: 6239:CELE_Y19D10A.5
uniprot id: G5EDB5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y47D3B.10
gene id: 6239:CELE_Y47D3B.10
uniprot id: Q10576
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P4HA family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen
messages: Heterotetramer of two alpha chains and two beta chains. Exists either as a phy-1(2)/pdi-2(2) tetramer or as a phy-1/phy-2/pdi-2(2) tetramer.

6239:CELE C41G6.3
gene id: 6239:CELE_C41G6.3
uniprot id: O17656
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZK795.1
gene id: 6239:CELE_ZK795.1
uniprot id: O62519
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

6239:CELE F08G5.2
gene id: 6239:CELE_F08G5.2
uniprot id: Q19221
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE M03F4.3
gene id: 6239:CELE_M03F4.3
uniprot id: Q23013
uniprot id: Q2L6V9
uniprot id: Q7JNP9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE F08C6.2
gene id: 6239:CELE_F08C6.2
uniprot id: P49583
uniprot id: Q3HKC4
names: Similarity
messages: Belongs to the cytidylyltransferase family.

6239:CELE T23H4.3
gene id: 6239:CELE_T23H4.3
uniprot id: P91828
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE H02I12.7
gene id: 6239:CELE_H02I12.7
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE T27F7.1
gene id: 6239:CELE_T27F7.1
uniprot id: Q9GYK4
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE ZK697.12
gene id: 6239:CELE_ZK697.12
uniprot id: Q7Z2B2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y48G1A.6
gene id: 6239:CELE_Y48G1A.6
uniprot id: A0SQM0
names: Disruption Phenotype
names: Subunit
messages: Interacts with histone H3 that is trimethylated at 'Lys-9' (H3K9me3).
messages: No visible phenotype.

6239:CELE F58H12.1
gene id: 6239:CELE_F58H12.1
uniprot id: Q21017
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated. Elevated cAMP levels appears to act via PKA to directly or indirectly phosphorylate multiple sites on kin-29 and inhibit function.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm
messages: Defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. Exhibit defects in food-induced quiescence behavior.
messages: Expressed throughout all stages of postembryonic development. Observed in the intestine and in cells in the tail during L1, L3 and L4.
messages: Interacts with tax-6.
messages: Nucleus
messages: Primarily neuronal, with additional expression in body wall muscle and hypodermal cells. Among neuronal cells, expressed in multiple sensory neurons and interneurons in the lateral, anterior, and lumbar ganglia, as well as in motor neurons in the ventral motor cord. Present in the AWB and AWC olfactory neurons.
messages: Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages.

6239:CELE Y51A2D.8
gene id: 6239:CELE_Y51A2D.8
uniprot id: Q9XXQ7
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE ZK370.4
gene id: 6239:CELE_ZK370.4
uniprot id: Q02331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Membrane

6239:CELE F40H6.4
gene id: 6239:CELE_F40H6.4
uniprot id: Q20257
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C44C1.5
gene id: 6239:CELE_C44C1.5
uniprot id: G8JY22
uniprot id: Q18610
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

6239:CELE T07D4.2
gene id: 6239:CELE_T07D4.2
uniprot id: Q22306
names: Similarity
messages: Belongs to the UPF0046 family.

6239:CELE Y37D8A.10
gene id: 6239:CELE_Y37D8A.10
uniprot id: Q9XWW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit sec-11 and three accessory subunits spcs-1, spcs-2 and spcs-3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
messages: Endoplasmic reticulum membrane

6239:CELE T17E9.2
gene id: 6239:CELE_T17E9.2
uniprot id: P46548
uniprot id: Q95ZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm

6239:CELE F23H12.4
gene id: 6239:CELE_F23H12.4
uniprot id: H2L2C4
uniprot id: P08124
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE ZK637.8
gene id: 6239:CELE_ZK637.8
uniprot id: P30628
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Expressed in embryos, larvae and adult. Highest level of expression is in early embryos (PubMed:11110798). Expressed in the nerve ring and ventral nerve cord in L1 larvae (PubMed:11441002).
messages: Membrane
messages: RNAi-mediated knockdown causes embryonic lethality at the 100-cell stage.
messages: Specifically expressed in the nervous system.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Regulates the size of gut granules during embryonic development (PubMed:20148972). In neurons, required for necrotic cell death by promoting intracellular acidification (PubMed:16005300). Required for cell death induced by hypoxia (PubMed:16005300). Required for acidification of synaptic vesicles and the release of neurotransmitters from adult neurons (PubMed:22426883).
messages: Ubiquitous expression in embryos. Expressed in gonads, intestine, neurons in the head and motoneurons in the ventral cord of larvae and adults (PubMed:11110798). Expressed in the vulvae and spermathecal uterine valves (PubMed:11441002). Weakly expressed in the pharynx (PubMed:11441002).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits vah-19/Ac45 and vah-20/PRR (By similarity). Interacts with V-type proton ATPase subunit C vha-11 (PubMed:11441002).

6239:CELE T27A8.2
gene id: 6239:CELE_T27A8.2
uniprot id: Q22826
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T22H6.1
gene id: 6239:CELE_T22H6.1
uniprot id: Q22687
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the IL-17 family.
messages: Expressed in RMG and AUA interneurons and ASE sensory neurons.
messages: Homodimer; disulfide-linked. Interacts with the receptor complex composed of ilcr-1 and ilcr-2 with the interaction being mediated by ilcr-2.
messages: Ligand for the receptor complex composed of ilcr-1 and ilcr-2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downstream signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones.
messages: Secreted

6239:CELE F35C12.2
gene id: 6239:CELE_F35C12.2
uniprot id: P90858
uniprot id: Q1ZXT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

6239:CELE M01B12.5
gene id: 6239:CELE_M01B12.5
uniprot id: O44959
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Cytoplasm
messages: Expressed in the nervous system at all larval stages. Expressed in somatic gonad and in the ventral nerve cord at L2 larval stage. Expressed in somatic gonad, in ventral uterine (VU/AC) cells and in the committed anchor cell at L3 larval stage. Expressed in vulF cells of the vulva, uterine cells and in uterine seam cells (utse) at L4 larval stage.
messages: Expressed in vulva and uterine cells, uterine seam cells (utse), spermatheca and in the nervous system including chemosensory neurons in the head, nerve ring neurons (RID/RIF), inhibitory motor neurons (DA/DD/VA/VD), mechanosensory neurons (ALML/PLML) and tail sensory neurons (DVA//PDA) (PubMed:24929033, PubMed:25688864). Also expressed in intestine and pharynx (procorpus) and rectal valve and gland (PubMed:25688864).
messages: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). Plays a role in oogenesis by regulating germ cell proliferation, progression through diplotene and diakinesis stages and oocyte maturation (PubMed:24929033, PubMed:25688864). Regulates germline development probably by regulating the phosphorylation of mpk-1 (PubMed:25688864). Involved in larval development (PubMed:24929033, PubMed:25688864).
messages: RNAi-mediated knockdown causes early larval arrest. In adults, results in sterility. Causes malformations of the gonad arms (empty or misshaped) and a protruding vulva (PubMed:24929033). Abnormal germline development characterized by a decrease in the number of proliferating germ cells in the mitotic and transition zones. At the diplotene stage, cells are disorganized and have enlarged nuclei. Oocytes have abnormal shape and large DNA aggregates next to abnormally located sperm. In addition, 50 percent of cells fails to decrease mpk-1 phosphorylation upon pachytene stage exit (PubMed:24929033, PubMed:25688864). RNAi-mediated knockdown in a let-60 n1046 mutant background suppresses the formation of multivulva (PubMed:24929033).

6239:CELE Y44A6B.4
gene id: 6239:CELE_Y44A6B.4
uniprot id: O62448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE Y46G5A.17
gene id: 6239:CELE_Y46G5A.17
uniprot id: Q9U2F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

6239:CELE F35C5.2
gene id: 6239:CELE_F35C5.2
uniprot id: Q9XVP3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y38F2AL.5
gene id: 6239:CELE_Y38F2AL.5
uniprot id: Q9N418
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y43F4B.10
gene id: 6239:CELE_Y43F4B.10
uniprot id: Q8MPP5
names: Similarity
messages: Belongs to the CDK2AP family.

6239:CELE T22F3.7
gene id: 6239:CELE_T22F3.7
uniprot id: Q94304
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F39G3.5
gene id: 6239:CELE_F39G3.5
uniprot id: H2KYX0
uniprot id: O16271
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T15B7.5
gene id: 6239:CELE_T15B7.5
uniprot id: O17035
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C03G6.12
gene id: 6239:CELE_C03G6.12
uniprot id: A0A131MB07
uniprot id: A0A131MB42
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F56D2.7
gene id: 6239:CELE_F56D2.7
uniprot id: O76337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ced-6 family.
messages: Cytoplasm
messages: Detected in gonadal sheath cells.
messages: Homodimer. Interacts with ced-1.
messages: May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development. Promotes engulfment of cells at both early and late stages of apoptosis. Required for actin reorganization around apoptotic cells. Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382).

6239:CELE F59E12.4
gene id: 6239:CELE_F59E12.4
uniprot id: H2KYU6
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NPL4 family.
messages: Cytoplasm
messages: Forms a complex composed of ubxn-3, ufd-1, npl-4.1 and cdc-48.1; within the complex, interacts with ufd-1 and ubxn-3 (PubMed:20977550). Interacts with ufd-1 (PubMed:16647269). Interacts with elc-1/elongin C; the interaction may mediate the interaction between the npl-4-ufd-1-cdc-48 complex and the E3 ubiquitin ligase cul-2 complex (PubMed:19773360).
messages: In association with ufd-1 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER (PubMed:16647269, PubMed:22768338). This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER (PubMed:16647269, PubMed:22768338). During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:18728180, PubMed:21981920, PubMed:26842564, PubMed:28368371). Regulates ubxn-3 nuclear localization during S phase (PubMed:26842564).
messages: Nucleus
messages: Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 causes embryonic lethality (PubMed:16647269, PubMed:26842564). In embryos, DNA replication is partially impaired causing a delay in S phase progression in P0, AB and P1 cells; simultaneous RNAi-mediated knockdown of DNA replication checkpoint kinases chk-1 or atl-1 suppresses the delay in S phase (PubMed:18728180, PubMed:26842564). During S phase, prevents DNA replication licensing factor cdt-1 down-regulation and causes cdt-1 accumulation on mitotic chromosomes (PubMed:21981920). Impairs dissociation from the chromatin of components of the DNA replication machinery, including cdc-45, GINS complex component sld-5 and CMG helicase component mcm-3, resulting in their persistent association with chromatin throughout embryonic mitosis (PubMed:21981920, PubMed:26842564, PubMed:28368371). Abnormal ubxn-3 localization into punctate structures in the nucleus (PubMed:26842564). Reduces ufd-1 expression in embryos (PubMed:21981920, PubMed:26842564). Simultaneous RNAi-mediated knockdown of npl-4.1 and npl-4.2 in adults causes a proliferation arrest of mitotic germline cells in the gonad with formation of rad-51 foci on chromatin (PubMed:18728180). Induces the unfolded protein response and increases sensitivity to tunicamycin-induced ER stress (PubMed:16647269). Causes accumulation of misfolded protein cpl-1 in the ER (PubMed:22768338).
messages: There is another gene, npl-4.2, which has a 99% identical sequence making it difficult to identify the specific function for each protein.

6239:CELE T23B3.4
gene id: 6239:CELE_T23B3.4
uniprot id: P91487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE F53A9.2
gene id: 6239:CELE_F53A9.2
uniprot id: Q20689
names: Disruption Phenotype
names: Function
names: Induction
names: Tissue Specificity
messages: By heavy metal stress conditions, in response to Cu(2+).
messages: Plays a role in the stress response to heavy metals such as copper, probably in a fos-1/kgb-1-dependent manner.
messages: RNAi-mediated knockdown results in partial sensitivity to Cu(2+) ions with only 60% of animals reaching adulthood 4 days after egg laying.
messages: Weakly expressed in the intestine, but expression is up-regulated in response to Cu(2+).

6239:CELE F20H11.5
gene id: 6239:CELE_F20H11.5
uniprot id: O01739
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAMOX/DASOX family.
messages: Expressed in probable head mesodermal cells and unidentified cells in the head, vulval muscles, hypodermis and the gonad sheath cells in adult hermaphrodites. Also expressed in the seminal vesicle and tail cells in adult males.
messages: Expression in head mesodermal cells detected from L3 stage to adult stages, and in vulval muscles from L4 stage to adult stages.
messages: Homodimer.
messages: Mutant worms have decreased egg-laying capacity at 20 degrees Celsius, and decreased hatching rate and smaller brood size at 25 degrees Celsius. They also show delay in growth to adulthood and an extended life span. Mutant worms have high D-Glu content at both egg and young adult stages and a high L-Trp level at young adult stage but do not show any change in physical appearance.
messages: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. Has no activity towards L-amino acids or N-methyl-L-aspartic acid. May play a role in the egg-laying events and maturation processes of the reproductive organs.
messages: extracellular space

6239:CELE F54C1.2
gene id: 6239:CELE_F54C1.2
uniprot id: Q10660
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control.
messages: Present at all stages. Levels increase from L1 to adult stages.

6239:CELE F43G9.6
gene id: 6239:CELE_F43G9.6
uniprot id: B2D6N9
uniprot id: Q17388
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ferlin family.
messages: Exclusively expressed in the testis.
messages: Membrane
messages: Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis.

6239:CELE C16A3.7
gene id: 6239:CELE_C16A3.7
uniprot id: Q18034
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: May play a role in transcription regulation.
messages: Nucleus

6239:CELE C05D11.3
gene id: 6239:CELE_C05D11.3
uniprot id: Q11183
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed from late embryogenesis onwards but mainly expressed at young adult and adult stages.
messages: Expressed throughout the body with high expression in the nervous system, including the ventral nerve cord and tail neurons, and vulva.
messages: Nucleus
messages: RNAi-mediated knockdown results in 60% embryonic lethality. Surviving 2-cell stage to 64-cell stage embryos display a disorganized arrangement and do not undergo cell divion. Due to short and diorganized microtubule arrangement, one cell stage embryos exhibit nuclear-centrosomal defects, failed cytokinesis, and abnormal pronuclear activity which include failed male pronucleus migration and the presence of multiple pronuclei.
messages: Required for normal microtubule organization and function (PubMed:15009089, PubMed:25575561). Regulates tubulin acetylation in ALM and PLM neurons (PubMed:25575561).

6239:CELE F11G11.1
gene id: 6239:CELE_F11G11.1
uniprot id: P91254
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE C01B10.6
gene id: 6239:CELE_C01B10.6
uniprot id: H2KYC9
uniprot id: Q8MQF7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F30F8.9
gene id: 6239:CELE_F30F8.9
uniprot id: Q8I4K3
uniprot id: Q95QI1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F28C12.5
gene id: 6239:CELE_F28C12.5
uniprot id: O18690
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE H13N06.6
gene id: 6239:CELE_H13N06.6
uniprot id: A0A0K3ATC0
uniprot id: Q9XTQ6
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Membrane
messages: Present in synaptic regions of RIC interneurons. Present in gonadal sheath cells of hermaphrodites (at protein level).
messages: Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter (PubMed:15848803). Involved in the regulation of egg laying, which is inhibited by tyramine (PubMed:15848803). Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity (PubMed:25723162).
messages: Worms are viable and healthy, but have slightly reduced locomotion rates, and defects in the inhibition of pharyngeal pumping and egg laying in the absence of food.

6239:CELE W03A5.2
gene id: 6239:CELE_W03A5.2
uniprot id: Q23135
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R05D7.3
gene id: 6239:CELE_R05D7.3
uniprot id: J7SA63
uniprot id: J7SEZ9
uniprot id: J7SF94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

6239:CELE T25D3.4
gene id: 6239:CELE_T25D3.4
uniprot id: A0A0K3ARQ9
uniprot id: A0A0K3AX26
uniprot id: Q965I9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F11C1.3
gene id: 6239:CELE_F11C1.3
uniprot id: Q19344
names: Similarity
messages: Belongs to the CD36 family.

6239:CELE B0244.10
gene id: 6239:CELE_B0244.10
uniprot id: Q960A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. B0244 subfamily.
messages: Cell membrane

6239:CELE ZK488.2
gene id: 6239:CELE_ZK488.2
uniprot id: O17025
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE R08D7.7
gene id: 6239:CELE_R08D7.7
uniprot id: P30646
names: Similarity
messages: Belongs to the FGGY kinase family.

6239:CELE ZK1236.2
gene id: 6239:CELE_ZK1236.2
uniprot id: P34618
names: Developmental Stage
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus
messages: Present in all somatic cells from the 50- to 80-cell stage on throughout development and in adult animals.

6239:CELE C35D10.15
gene id: 6239:CELE_C35D10.15
uniprot id: Q95QR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C15A7.2
gene id: 6239:CELE_C15A7.2
uniprot id: Q18000
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F09G8.6
gene id: 6239:CELE_F09G8.6
uniprot id: P34391
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE C17H12.2
gene id: 6239:CELE_C17H12.2
uniprot id: O45086
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F46G10.6
gene id: 6239:CELE_F46G10.6
uniprot id: Q18711
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MAX family.
messages: Cytoplasm
messages: Down-regulated by fasting.
messages: Expressed in the intestine and in the AWC sensory neurons.
messages: May form homodimer (PubMed:19632181). Interacts (via N-terminus) with skn-1 isoforms a and c (PubMed:23040073).
messages: Nucleus
messages: RNAi-mediated knockdown causes a depletion of fat stores. RNAi-mediated knockdown in the intestine causes a fasting-like transcriptional response, characterized by the up-regulation of the lipl-1 gene transcription.
messages: Transcription factor which regulates the expression of genes involved in lipid metabolism in response to nutrient availability (PubMed:23604316, PubMed:29113111). Binds to the E-box motif 5'-CACGTG-3' (PubMed:19632181). Under well-fed conditions, binds to the promoter and represses the expression of lipase genes lipl-1, lipl-2, lipl-3 and to a lesser extent lipl-5, thereby preventing lipolysis (PubMed:23604316). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation by up-regulating transcription factor sbp-1 expression (PubMed:29113111). Under well-fed conditions, acts remotely in the intestine to up-regulate the expression of chemoreceptor srh-234 gene in the ADL sensory neuron, possibly by regulating the insulin signaling pathway (PubMed:27487365).

6239:CELE F22B3.8
gene id: 6239:CELE_F22B3.8
uniprot id: Q19704
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE Y102A11A.6
gene id: 6239:CELE_Y102A11A.6
uniprot id: Q95XJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane

6239:CELE C34C6.1
gene id: 6239:CELE_C34C6.1
uniprot id: Q18428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE M01F1.4
gene id: 6239:CELE_M01F1.4
uniprot id: Q21453
uniprot id: Q5CZ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

6239:CELE C44C10.1
gene id: 6239:CELE_C44C10.1
uniprot id: Q18620
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE D2023.1
gene id: 6239:CELE_D2023.1
uniprot id: G5EBI9
uniprot id: G5EGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C26F1.2
gene id: 6239:CELE_C26F1.2
uniprot id: Q27472
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C48B6.6
gene id: 6239:CELE_C48B6.6
uniprot id: O01510
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family.
messages: Component of a post-splicing multiprotein NMD complex.
messages: Cytoplasm
messages: Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.

6239:CELE B0273.3
gene id: 6239:CELE_B0273.3
uniprot id: O44168
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6239:CELE Y48C3A.14
gene id: 6239:CELE_Y48C3A.14
uniprot id: H1UBJ9
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

6239:CELE T07H8.4
gene id: 6239:CELE_T07H8.4
uniprot id: H2KZ68
uniprot id: Q5ZR39
uniprot id: Q5ZR42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T03F7.1
gene id: 6239:CELE_T03F7.1
uniprot id: G5EF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

6239:CELE C14A4.10
gene id: 6239:CELE_C14A4.10
uniprot id: Q17957
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F57C9.1
gene id: 6239:CELE_F57C9.1
uniprot id: G8JXZ7
uniprot id: H1ZUV6
uniprot id: O01824
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the pyridoxine kinase family.
messages: Divalent metal cations. Zn(2+) is more efficient than Mg(2+).
messages: Required for synthesis of pyridoxal-5-phosphate from vitamin B6.

6239:CELE W02D9.2
gene id: 6239:CELE_W02D9.2
uniprot id: C6KRN3
uniprot id: D7SFP5
uniprot id: O02335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

6239:CELE F44E5.4
gene id: 6239:CELE_F44E5.4
uniprot id: G5ECU5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

6239:CELE R13F6.3
gene id: 6239:CELE_R13F6.3
uniprot id: P46564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srv family.
messages: Membrane

6239:CELE T05C12.3
gene id: 6239:CELE_T05C12.3
uniprot id: Q22230
names: Function
names: Similarity
messages: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

6239:CELE ZK20.6
gene id: 6239:CELE_ZK20.6
uniprot id: Q18673
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane
messages: Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping.
messages: Specifically expressed in pharyngeal cells and a single head neuron.

6239:CELE C52D10.9
gene id: 6239:CELE_C52D10.9
uniprot id: G5ECY4
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE ZC434.6
gene id: 6239:CELE_ZC434.6
uniprot id: A5Z2T7
uniprot id: Q23316
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nicastrin family.
messages: Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2.
messages: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
messages: Membrane

6239:CELE T14B4.6
gene id: 6239:CELE_T14B4.6
uniprot id: P35799
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.

6239:CELE F59B2.6
gene id: 6239:CELE_F59B2.6
uniprot id: P34482
names: Function
names: Subunit
messages: Probable component of the CBC(zif-1) E3 ubiquitin-protein ligase complex formed of cul-2, elc-1, rbx-1 and zif-1. Interacts with pie-1, pos-1, mex-1, mex-5, mex-6 and elc-1.
messages: Probable substrate recognition component of a CBC (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2.

6239:CELE F35B12.10
gene id: 6239:CELE_F35B12.10
uniprot id: H9G2X9
uniprot id: H9G2Y0
uniprot id: Q7YX42
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of burs and pburs.
messages: Secreted

6239:CELE D2007.5
gene id: 6239:CELE_D2007.5
uniprot id: P34379
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Component of the unc-51/atg-13 complex required for autophagosome formation (PubMed:19377305, PubMed:26687600). Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells (PubMed:19377305). This ensures exclusive localization of the P-granules in germ cells (PubMed:19377305). May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation (PubMed:19377305). Plays a role in survival during limited food availability (PubMed:19377305).
messages: Cytoplasm
messages: Expressed from the 8-cell stage and subsequently throughout embryogenesis. After hatching, highly expressed in neurons including nerve ring cells, neurons in the tail and DD/VD motor neurons in the ventral nerve cord. Also expressed in body wall muscle and pharyngeal muscle.
messages: Interacts with unc-51 (via C-terminus) (PubMed:19377305). Interacts with lgg-1; the interaction is direct (PubMed:26687600).
messages: Perikaryon
messages: Preautophagosomal structure
messages: axon
messages: cytosol

6239:CELE C54G10.2
gene id: 6239:CELE_C54G10.2
uniprot id: Q18841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

6239:CELE T26E4.16
gene id: 6239:CELE_T26E4.16
uniprot id: Q7YWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y45G5AM.1
gene id: 6239:CELE_Y45G5AM.1
uniprot id: G5EEM0
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in germ and intestinal cells and at low levels in the hypodermis.
messages: First expressed in the embryo and subsequently in larvae and adults.
messages: It has been reported that mutant phenotypes can be rescued by tryptophan dietary supplementation, but not by methionine (PubMed:23499532). However, a later report describes successful phenotype rescue by methionine supplementation; this may be due to methodological differences (PubMed:33016879).
messages: No obvious somatic morphological defects in adults (PubMed:23499532). However, shows diet-sensitive sterility arising from germ-cell proliferation defects (PubMed:23499532). Sterile when fed the standard bacterial strain, E.coli B (OP50) as food source, and fertile when maintained on E.coli K-12 strains or bacterial soil isolates (PubMed:23499532). Dietary supplementation of L-tryptophan, but not the D isomer, to E.coli B strains suppresses sterility; this effect requires live bacteria (PubMed:23499532). Sterility when fed E.coli B strain OP50 can be rescued by dietary supplementation of either vitamin B12, methionine or choline (PubMed:33016879). RNAi-mediated knockdown targeted to the intestine, but not the germline, restored almost normal fertility on an E.coli OP50 diet (PubMed:23499532). RNAi-mediated knockdown on a rrf-1 mutant background, in which knockdown occurs mainly in the germline but occurs only weakly in somatic tissues, allowed recovery of a majority (64%) of fertile animals (PubMed:23499532). RNAi-mediated knockdown on an nhr-10 mutant background suppresses expression of acdh-1 (PubMed:33016879).
messages: Nucleus
messages: Probable transcription factor which may have a role in detoxifying dietary metabolites arising from bacterial tryptophan metabolism (PubMed:23499532). Required for fertility and involved in proper postembryonic germline development, especially germline stem cell (GSC) proliferation (PubMed:23499532). Required for activation of the methionine/S-adenosylmethionine (Met/SAM) cycle in response to low levels of SAM (PubMed:33016879).

6239:CELE Y106G6E.4
gene id: 6239:CELE_Y106G6E.4
uniprot id: Q9XWE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
messages: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity).
messages: Cytoplasm
messages: Monomer.

6239:CELE D1005.1
gene id: 6239:CELE_D1005.1
uniprot id: P53585
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
messages: Cytoplasm
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

6239:CELE T24D8.1
gene id: 6239:CELE_T24D8.1
uniprot id: Q22741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F10G8.7
gene id: 6239:CELE_F10G8.7
uniprot id: Q93456
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

6239:CELE Y76A2B.6
gene id: 6239:CELE_Y76A2B.6
uniprot id: G5EBM7
names: Similarity
messages: Belongs to the CD36 family.

6239:CELE T28B8.5
gene id: 6239:CELE_T28B8.5
uniprot id: P91835
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C02B4.1
gene id: 6239:CELE_C02B4.1
uniprot id: G5ECS8
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: In hermaphrodites, expressed in the vulva, head ganglia, ventral nerve cord and amphid neurons. Expressed in the rays of the male tail.
messages: Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle.
messages: Secreted
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

6239:CELE R10E11.7
gene id: 6239:CELE_R10E11.7
uniprot id: P34551
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srxa family.
messages: Membrane

6239:CELE F17C11.8
gene id: 6239:CELE_F17C11.8
uniprot id: Q19519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

6239:CELE F47D12.4
gene id: 6239:CELE_F47D12.4
uniprot id: Q09390
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Nucleus

6239:CELE ZK637.10
gene id: 6239:CELE_ZK637.10
uniprot id: P30635
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.
messages: The active site is a redox-active disulfide bond.

6239:CELE F30F8.10
gene id: 6239:CELE_F30F8.10
uniprot id: A5JYV6
uniprot id: Q7YX26
names: Similarity
messages: Belongs to the acetyltransferase family. NAA60 subfamily.

6239:CELE E01A2.4
gene id: 6239:CELE_E01A2.4
uniprot id: Q966L6
names: Similarity
messages: Belongs to the NKAP family.

6239:CELE C04F5.1
gene id: 6239:CELE_C04F5.1
uniprot id: Q9GZC8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Absence of silencing in adjacent cells or tissues. Decrease in transgene silencing when combined with eri-1.
messages: Belongs to the SID1 family.
messages: Cell membrane
messages: Expressed in most non-neuronal cells, including body wall muscle cells.
messages: Expressed throughout all developmental stages.
messages: May self-associate to form multimers.
messages: Plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent (PubMed:26067272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307).
messages: This avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never been exposed to this pathogenic bacteria.

6239:CELE ZK757.2
gene id: 6239:CELE_ZK757.2
uniprot id: P34680
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

6239:CELE R06A4.4
gene id: 6239:CELE_R06A4.4
uniprot id: A0A131MBF9
uniprot id: O62332
uniprot id: O62333
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE F59A2.3
gene id: 6239:CELE_F59A2.3
uniprot id: Q21018
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Mitochondrion matrix

6239:CELE F57A10.2
gene id: 6239:CELE_F57A10.2
uniprot id: O45592
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C40A11.6
gene id: 6239:CELE_C40A11.6
uniprot id: Q9TZA8
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE ZK896.9
gene id: 6239:CELE_ZK896.9
uniprot id: E5QCI0
uniprot id: O02345
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K06A5.3
gene id: 6239:CELE_K06A5.3
uniprot id: O44550
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE K12D9.5
gene id: 6239:CELE_K12D9.5
uniprot id: P91380
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE R151.6
gene id: 6239:CELE_R151.6
uniprot id: Q21997
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: By endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins.

6239:CELE F17E9.9
gene id: 6239:CELE_F17E9.9
uniprot id: P04255
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
messages: Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE ZK1098.4
gene id: 6239:CELE_ZK1098.4
uniprot id: P34604
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

6239:CELE T19C3.4
gene id: 6239:CELE_T19C3.4
uniprot id: Q10010
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE Y55F3AM.9
gene id: 6239:CELE_Y55F3AM.9
uniprot id: Q9N370
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

6239:CELE T07D1.1
gene id: 6239:CELE_T07D1.1
uniprot id: A0A163UTN8
uniprot id: Q86C56
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in a pair of bilaterally symmetric neurons in the head.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE Y39C12A.5
gene id: 6239:CELE_Y39C12A.5
uniprot id: Q9U2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y53F4B.42
gene id: 6239:CELE_Y53F4B.42
uniprot id: Q2MDF2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

6239:CELE T04G9.2
gene id: 6239:CELE_T04G9.2
uniprot id: P55115
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal marginal cells and muscles.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y110A7A.14
gene id: 6239:CELE_Y110A7A.14
uniprot id: Q9N599
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

6239:CELE C29G2.6
gene id: 6239:CELE_C29G2.6
uniprot id: O16887
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0222.9
gene id: 6239:CELE_B0222.9
uniprot id: Q960A1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters per subunit.
messages: May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1.
messages: RNAi-mediated knockdown reduces both the longevity-extending effects and generation of reactive oxygen species when exposed to 1 microM N1-methylnicotinamide.

6239:CELE F32D8.14
gene id: 6239:CELE_F32D8.14
uniprot id: H9G2X8
uniprot id: Q7YTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

6239:CELE F26G1.11
gene id: 6239:CELE_F26G1.11
uniprot id: A7LPC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T01G1.4
gene id: 6239:CELE_T01G1.4
uniprot id: Q5FC21
names: Similarity
messages: Belongs to the UPP synthase family.

6239:CELE W05H5.3
gene id: 6239:CELE_W05H5.3
uniprot id: P91840
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

6239:CELE Y38H8A.3
gene id: 6239:CELE_Y38H8A.3
uniprot id: O62426
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F17E9.11
gene id: 6239:CELE_F17E9.11
uniprot id: O61518
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

6239:CELE T21D11.1
gene id: 6239:CELE_T21D11.1
uniprot id: G5ECC4
names: Similarity
messages: Belongs to the peptidase M10A family.

6239:CELE T20D4.5
gene id: 6239:CELE_T20D4.5
uniprot id: P91470
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE F02E8.2
gene id: 6239:CELE_F02E8.2
uniprot id: Q19125
uniprot id: Q7JNX1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE T01D3.6
gene id: 6239:CELE_T01D3.6
uniprot id: G5EDT4
uniprot id: G5EEP7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

6239:CELE K09D9.2
gene id: 6239:CELE_K09D9.2
uniprot id: Q9N5I1
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE M01F1.3
gene id: 6239:CELE_M01F1.3
uniprot id: Q21452
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6239:CELE E03G2.3
gene id: 6239:CELE_E03G2.3
uniprot id: G5EFQ9
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE Y53G8B.2
gene id: 6239:CELE_Y53G8B.2
uniprot id: Q9N4S3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE D1044.2
gene id: 6239:CELE_D1044.2
uniprot id: P41950
names: Developmental Stage
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development (PubMed:19344940). Promotes seam cell remodeling during the dauer phase (PubMed:30409788). Plays a role in positively regulating locomotion during the dauer phase (PubMed:30409788).
messages: Expression is first apparent in bean-stage embryos, peaks in late embryogenesis, reduces in L1 larvae and is negligible in later larval stages and adults (PubMed:19344940). In the embryo, expressed in the excretory cell and, during dendrite formation, in the non-neuronal cells surrounding the sensory neurons, including hypodermal cells (PubMed:19344940). Expressed in pharyngeal cells throughout the larval stages (PubMed:30409788). Expression in the seam cells and glia socket cells of the anterior and posterior deirid neurons begins at the L2 pre-dauer stage and persists throughout the dauer phase (PubMed:30409788). During the dauer phase expressed along the length of the animal above seam cells, alternating between alae under the outer ridges and below the lateral ridge (PubMed:30409788).
messages: May be proteolytically cleaved and secreted.
messages: Membrane
messages: Secreted
messages: dendrite

6239:CELE ZC376.4
gene id: 6239:CELE_ZC376.4
uniprot id: Q23269
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F46F5.7
gene id: 6239:CELE_F46F5.7
uniprot id: A0A0S4XRR1
uniprot id: A0A0S4XRV8
uniprot id: Q9TXY2
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C52D10.8
gene id: 6239:CELE_C52D10.8
uniprot id: G5EEX4
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE Y73E7A.2
gene id: 6239:CELE_Y73E7A.2
uniprot id: Q9GUM5
names: Similarity
messages: Belongs to the AATF family.

6239:CELE C01H6.4
gene id: 6239:CELE_C01H6.4
uniprot id: Q17585
names: Similarity
messages: Belongs to the FMO family.

6239:CELE W07G1.6
gene id: 6239:CELE_W07G1.6
uniprot id: Q9XUJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE R12E2.9
gene id: 6239:CELE_R12E2.9
uniprot id: O61786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE B0218.3
gene id: 6239:CELE_B0218.3
uniprot id: Q17446
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by phosphorylation on threonine and tyrosine. Inhibited by pyridinyl-imidazole related compounds.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Divalent cations such as magnesium or manganese.
messages: Dually phosphorylated on Thr-191 and Tyr-193, probably by sek-1, which activates the enzyme (PubMed:16166371, PubMed:21212236). Increased phosphorylation in response to the heavy metal arsenite (PubMed:25204677). Increased phosphorylation in response to intestinal colonization by probiotic Lactobacillus fermentum strain JDFM216 (PubMed:29748542).
messages: Expressed in intestinal cells.
messages: Interacts with transcription factor atf-7; perhaps in a manner dependent on dual specificity protein kinase sek-1.
messages: Knockout causes reduction in adult lifespan (PubMed:29748542). Upon infection by P.aeruginosa or E.faecalis, RNAi-mediated knockdown results in a decrease in survival rate and in a reduced up-regulation of gst-4 and gcs-1 expression (PubMed:12142542, PubMed:22216003). Causes a severe reduction in rnt-1 accumulation in the intestine during oxidative stress mediated by paraquat (PubMed:22308034). Upon exposure to C.cinerea galectin Cgl2, adults show reduced survival and larvae do not develop (PubMed:20062796). Larval development is partially restored in a bre-1, fut-8, gly-13, galt-1 or ger-1 mutant background (PubMed:20062796).
messages: Nucleus
messages: Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets (PubMed:11703092, PubMed:12142542, PubMed:16166371, PubMed:18394898, PubMed:22308034, PubMed:20369020). As part of a MAP kinase signaling pathway, plays a role in modulation of lifespan and immunity (PubMed:29748542, PubMed:12142542, PubMed:20369020, PubMed:22216003). Phosphorylates skn-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress (PubMed:16166371). Probably by activating skn-1, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection (PubMed:22216003). Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment (PubMed:16166371, PubMed:25204677). Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase which regulates pathogen resistance and responses to oxidative stress (PubMed:11703092, PubMed:12142542, PubMed:16166371, PubMed:18394898). Required for expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury (PubMed:18394898). Involved in resistance to the nematotoxic C.cinerea galectin (Cgl2) (PubMed:20062796). May play a redundant role with other MAP kinases in susceptibility to anoxia, downstream of tir-1/nsy-1 (PubMed:21212236). Phosphorylates transcription factor rnt-1 during oxidative stress which results in rnt-1 stabilization in the intestine (PubMed:22308034). Phosphorylates transcription factor atf-7 during pathogen infection resulting in modulation of target genes (PubMed:20369020). Probably downstream of nsy-1 and sek-1, involved in germline apoptosis induced by heavy metals, such as Cu(2+) (PubMed:19497412).
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

6239:CELE F49E12.5
gene id: 6239:CELE_F49E12.5
uniprot id: Q20618
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein sra family.
messages: Chemosensory receptor that negatively regulates RAS/MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit.
messages: Expressed in the AWA and AWC chemosensory neurons.
messages: Membrane

6239:CELE Y48B6A.4
gene id: 6239:CELE_Y48B6A.4
uniprot id: Q9U298
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping (PubMed:15020415, PubMed:8601480). Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity (PubMed:8462849, PubMed:9789046, PubMed:15141086, PubMed:28853436, PubMed:30965033). Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine (PubMed:30965033).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Expressed in pharyngeal muscle.
messages: Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.
messages: Postsynaptic cell membrane
messages: Worms exhibit a lack of MC neurotransmission possibly explaining the observed reduction in pharyngeal pumping rate (PubMed:15020415). Mutants show differences in their pharyngeal responses to nicotine (PubMed:15020415). A variety of mutants show an increase in lifespan ranging from 29-57% longer than wild-type (PubMed:15141086, PubMed:28853436). Extended self-fertile reproductive span, fast body movement, and a longer pharyngeal pumping span (PubMed:15141086). The strongest allele (ad1113) shows retarded growth (PubMed:15141086). Animals generally have smaller nucleoli (PubMed:28853436). Double knockout with ncl-1 reduces the increased longevity and suppresses the reduced nucleoli size phenotype of the eat-2 single mutant, and reduces the increased ribosomal protein synthesis in the ncl-1 single mutant (e1942) (PubMed:28853436).

6239:CELE C48G7.3
gene id: 6239:CELE_C48G7.3
uniprot id: G5ECF0
uniprot id: G5EDQ3
uniprot id: G5EG71
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

6239:CELE ZK637.2
gene id: 6239:CELE_ZK637.2
uniprot id: P30629
names: Similarity
messages: Belongs to the FAM136 family.

6239:CELE Y71H2AM.22
gene id: 6239:CELE_Y71H2AM.22
uniprot id: Q3V5J5
uniprot id: Q9BL31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C16D9.6
gene id: 6239:CELE_C16D9.6
uniprot id: Q22900
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05G5.5
gene id: 6239:CELE_T05G5.5
uniprot id: P34558
names: Similarity
messages: Belongs to the CoaE family.

6239:CELE C31B8.8
gene id: 6239:CELE_C31B8.8
uniprot id: G5EBU3
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Inhibited by human TIMP1 and TIMP2 and the broad MMP inhibitors BB94 (Batimastat) and CT543.
messages: Metalloproteinase.
messages: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
messages: extracellular matrix

6239:CELE K09E4.2
gene id: 6239:CELE_K09E4.2
uniprot id: E5QCI3
uniprot id: E5QCI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 58 family.
messages: Membrane

6239:CELE F59F3.2
gene id: 6239:CELE_F59F3.2
uniprot id: Q21039
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE Y71A12B.4
gene id: 6239:CELE_Y71A12B.4
uniprot id: Q9GRV5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T10B9.3
gene id: 6239:CELE_T10B9.3
uniprot id: Q27515
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE ZC581.1
gene id: 6239:CELE_ZC581.1
uniprot id: O01775
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
messages: Cytoplasm
messages: Expressed in hypodermal cells including in hyp7 syncytium but not in seam cells.
messages: Failure to shed the cuticle at the end of the first molt resulting in an arrest at the L1 to L2 transition stage. RNAi-mediated knockdown results in a less severe phenotype characterized by a failure to shed the cuticle only in the middle part of the body at the end of the first molt. In hyp7 syncytium, RNAi-mediated knockdown results in the apical membrane accumulation of lrp-1 and mislocalization of several components of the endocytic machinery.
messages: Probable serine/threonine-protein kinase required for the completion of molting. May play a role in endocytosis in the hypodermis syncytium.

6239:CELE K02F3.2
gene id: 6239:CELE_K02F3.2
uniprot id: Q21153
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Binds to one calcium ion with high affinity.
messages: Homodimer (via N-terminus).
messages: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane
messages: Upon calcium binding, the EF-hand-containing regulatory N-terminal domain binds to the C-terminal domain, opening a vestibule which allows the substrates to be translocated through the carrier domain. In the absence of calcium, the linker loop domain may close the vestibule, which may prevent substrates from entering the carrier domain.

6239:CELE M03C11.2
gene id: 6239:CELE_M03C11.2
uniprot id: Q21489
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Nucleus
messages: Required for normal cell proliferation and chromosome stability. Plays a role in DNA repair during replication.
messages: Uncoordinated and sterile with cell proliferation defects in germ and somatic cells. Hermaphrodite gonads have fewer cells with 13% of homozygotes having only one gonad arm. Most hermaphrodite mutants contain sperm but only 20% contain oocytes that develop as far as diakinesis and those that develop exhibit abnormal karyotypes. Mutant adults contain significantly fewer D neurons and seam cells than wild type. No poly-guanine tract deletions but double mutants of chl-1 and dog-1 display increased deletion frequency when compared to dog-1 mutants.

6239:CELE F26G1.3
gene id: 6239:CELE_F26G1.3
uniprot id: Q19827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C36C5.7
gene id: 6239:CELE_C36C5.7
uniprot id: Q8ITZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T26E3.7
gene id: 6239:CELE_T26E3.7
uniprot id: O45827
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

6239:CELE K08D10.13
gene id: 6239:CELE_K08D10.13
uniprot id: D5MCN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK973.3
gene id: 6239:CELE_ZK973.3
uniprot id: Q9N4M0
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE F36H1.6
gene id: 6239:CELE_F36H1.6
uniprot id: G5ECV9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

6239:CELE F36F2.4
gene id: 6239:CELE_F36F2.4
uniprot id: O62236
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

6239:CELE C09B8.7
gene id: 6239:CELE_C09B8.7
uniprot id: Q17850
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Divalent cations such as magnesium or manganese.
messages: Highly expressed at the embryonic stage, with decreasing expression from L1 onwards.
messages: In pak-1 and pak-2 double mutants, defects in embryogenesis and L1 stage lethality. The few animals reaching adulthood have normal ventral cord commissural motoneuron axonal guidance and are relatively coordinated. In max-2 and pak-1 double mutants, DD and DC motoneuron axons fail to reach the dorsal cord (PubMed:17050621). Animals are also uncoordinated, defective in egg laying and in distal tip cell (DTC) migration, guidance and morphology, and exhibit ventral enclosure defects (PubMed:17050621, PubMed:19023419).
messages: Interacts with cdc-42 (GTP-bound form) and cedd-10 (GTP-bound form).
messages: Perikaryon
messages: Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291). Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes (PubMed:17050621). Involved in orientating axonal growth of HSN neurons (PubMed:18499456). During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation (PubMed:19023419, PubMed:19797046). May phosphorylate mlc-4 (PubMed:19675126).
messages: Specifically colocalized with cdc-42 and ced-10 at all hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis. Expressed mainly in pharyngeal muscles, the CAN neurons, motor neurons in the ventral nerve cord, several cells in the tail region (including the B and Y cells from L1 to adult, the hypodermal blast cell T in the L1 and some of its progeny in later stages), and the distal tip cells.
messages: axon

6239:CELE H05B21.3
gene id: 6239:CELE_H05B21.3
uniprot id: O61970
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y45F10C.2
gene id: 6239:CELE_Y45F10C.2
uniprot id: O45941
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the UPF0375 family.
messages: Expressed in the uterine epithelium.
messages: Negatively regulates the egg-laying rate by promoting retention of fertilized eggs.
messages: Secreted

6239:CELE T26E3.2
gene id: 6239:CELE_T26E3.2
uniprot id: O45830
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

6239:CELE R07E5.8
gene id: 6239:CELE_R07E5.8
uniprot id: Q21829
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

6239:CELE K05D4.4
gene id: 6239:CELE_K05D4.4
uniprot id: O45659
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE LEV-10
gene id: 6239:CELE_LEV-10
uniprot id: C0Z3M3
uniprot id: G5EDX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T01D3.5
gene id: 6239:CELE_T01D3.5
uniprot id: Q9XVJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

6239:CELE F09E5.17
gene id: 6239:CELE_F09E5.17
uniprot id: Q8IG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

6239:CELE W06D11.4
gene id: 6239:CELE_W06D11.4
uniprot id: Q23200
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

6239:CELE Y92H12BL.1
gene id: 6239:CELE_Y92H12BL.1
uniprot id: Q8MXQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Membrane

6239:CELE C23G10.3
gene id: 6239:CELE_C23G10.3
uniprot id: P48152
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

6239:CELE F42A6.9
gene id: 6239:CELE_F42A6.9
uniprot id: O44490
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE Y19D10A.6
gene id: 6239:CELE_Y19D10A.6
uniprot id: Q966D9
uniprot id: Q9N5R0
names: Caution
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Metalloprotease.
messages: Secreted

6239:CELE C24B9.15
gene id: 6239:CELE_C24B9.15
uniprot id: Q86B38
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE B0025.1
gene id: 6239:CELE_B0025.1
uniprot id: Q9TXI7
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the PI3/PI4-kinase family.
messages: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PubMed:11927551). Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking (PubMed:11927551, PubMed:16111945). Plays a role in endosome-to-Golgi retrograde transport of mig-14 (PubMed:21183797). Involved in clearance of apoptotic cell corpses by phagosomes (PubMed:22272187). Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7, downstream of dynamin dyn-1 (PubMed:22272187, PubMed:18425118). The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse (PubMed:22272187). Required for embryonic development (PubMed:22272187). Together with bec-1, involved in L3/L4 larval molting stage probably by regulating cuticle shedding (PubMed:11927551). Regulates the expansion of the nucleus outer membrane (PubMed:11927551). Involved in the secretion and localization of lrp-1 at the apical surface of hyp7 syncytium (PubMed:16111945). May regulate endocytosis in hypodermal cells (PubMed:11927551). May play a role in the formation of gut granules (a lysosome-related organelle) (PubMed:15843430). Plays a role in germ stem cell proliferation during larval development (PubMed:28285998).
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Highly expressed in embryos and at L2 larval stage, and to a lower extent in subsequent larval stages and in adults.
messages: Inhibited by wortmannin.
messages: Interacts with bec-1 (PubMed:16111945, PubMed:26783301). May interact with dyn-1 (PubMed:18425118).
messages: Nucleus outer membrane
messages: RNAi-mediated knockdown causes a defect in the clearance of apoptotic cell corpses in gonads, a loss of rab-5 recruitment to cell corpse-containing nascent phagosomes and a decrease in PI3P levels on phagosome membranes (PubMed:18425118, PubMed:22272187). In addition, causes a reduction in mig-14 and rme-8 association with puncta structures as well as an increase in mig-14 protein levels (PubMed:21183797). RNAi-mediated knockdown results in reduced germ stem cell proliferation during larval development (PubMed:28285998).
messages: Ubiquitous.
messages: phagocytic cup

6239:CELE C50D2.4
gene id: 6239:CELE_C50D2.4
uniprot id: O44796
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE B0272.2
gene id: 6239:CELE_B0272.2
uniprot id: P41941
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR2 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Part of a unique SNARE complex.
messages: cis-Golgi network membrane

6239:CELE F32E10.4
gene id: 6239:CELE_F32E10.4
uniprot id: Q19969
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the importin alpha family.
messages: Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:11311162). Promotes docking of import substrates to the nuclear envelope (PubMed:11311162). Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (PubMed:11311162). Necessary for correct nucleoporin localization within the germline (PubMed:11311162). Essential gene for embryonic and larval development (PubMed:11311162). May be dispensable for axon development, but required for axon regeneration in both mechanosensory and motor neurons (PubMed:31417366). Required for oogenic development, ima-1 and ima-2 cannot functionally compensate for loss of ima-3 (PubMed:11311162).
messages: Cytoplasm
messages: Expressed at high levels throughout all developmental stages.
messages: Expressed in larval and adult germline and somatic tissues, including neurons.
messages: Forms a complex with an importin beta subunit (PubMed:11311162). May interact with transcription factor cebp-1 (via N-terminus) (PubMed:31417366).
messages: Larval lethality (PubMed:31417366). Mechanosensory neurons are born and develop normally (PubMed:31417366). However, cre-mediated knockdown targeted to mechanosensory neurons severely impairs axon regrowth of mechanosensory PLM neurons after injury (PubMed:31417366).
messages: Nucleus

6239:CELE C28D4.9
gene id: 6239:CELE_C28D4.9
uniprot id: Q95QT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C09G4.2
gene id: 6239:CELE_C09G4.2
uniprot id: H2KYN1
uniprot id: H2KYN2
uniprot id: Q8MQE2
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

6239:CELE F29C4.8
gene id: 6239:CELE_F29C4.8
uniprot id: A0A0F6YQF6
uniprot id: A0A131MAZ6
uniprot id: A0A131MB32
uniprot id: A0A131MBJ3
uniprot id: A0A131MBJ4
uniprot id: A0A131MBK4
uniprot id: A0A131MBL6
uniprot id: A0A131MBQ9
uniprot id: A0A131MCG3
uniprot id: A0A131MCS7
uniprot id: A0A131MCY1
uniprot id: A0A131MD72
uniprot id: O76368
uniprot id: U4PC95
uniprot id: U4PMN6
uniprot id: U4PRZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE C45E5.1
gene id: 6239:CELE_C45E5.1
uniprot id: Q18645
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

6239:CELE H12C20.6
gene id: 6239:CELE_H12C20.6
uniprot id: Q95ZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F49F1.1
gene id: 6239:CELE_F49F1.1
uniprot id: Q9GZE5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK973.10
gene id: 6239:CELE_ZK973.10
uniprot id: Q9N4L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mitochondrion inner membrane

6239:CELE ZK40.1
gene id: 6239:CELE_ZK40.1
uniprot id: Q23087
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6239:CELE K05F1.2
gene id: 6239:CELE_K05F1.2
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE K02A4.1
gene id: 6239:CELE_K02A4.1
uniprot id: P54688
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
messages: Cytoplasm
messages: Expression decreases with increasing age.
messages: RNAi-mediated knockdown extends mean lifespan by 25% and maximum lifespan by 19%, increases maximum moving speed, and increases levels of the enzyme substrates, L-leucine, L-isoleucine and L-valine.

6239:CELE K03B8.5
gene id: 6239:CELE_K03B8.5
uniprot id: Q21181
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE F26E4.5
gene id: 6239:CELE_F26E4.5
uniprot id: O01325
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE R07C3.1
gene id: 6239:CELE_R07C3.1
uniprot id: O16778
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F15H10.1
gene id: 6239:CELE_F15H10.1
uniprot id: P20630
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE K11E8.1
gene id: 6239:CELE_K11E8.1
uniprot id: G5EDZ5
uniprot id: O62305
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria (PubMed:23325232, PubMed:23505381). Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
messages: Ca2(+)/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca(2+)/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca(2+) pulses to become Ca(2+) independent.
messages: Cytoplasm
messages: Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule (PubMed:16441656, PubMed:20139983). Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1 (PubMed:15625192, PubMed:21145946). Interacts with nsy-1 (PubMed:11336672).
messages: Expressed in the nervous system. Observed in the ADF and AWC neurons. Position in AWC neurons is regulated by microtubules. Localized to clusters in ventral cord neurites which appear to be required for glr-1 trafficking. Also present in oocytes.
messages: Increased frequency of defecation, typified by a weaker repetition of the defecation motor program, an echo, 10 s after the primary motor program. Abnormal spicule protraction. Lack of tph-1 transcriptional up-regulation during learned olfactory aversion to bacteria. Reduced brood size, body length and width. Lethargic movement. A gain-of function mutation reduces locomotory activity, alters excitation of three muscle types and lengthens the period of the motor output of a behavioral clock. Both classes of mutation inhibit neurotransmitter release.
messages: Perikaryon
messages: axon

6239:CELE T24A6.11
gene id: 6239:CELE_T24A6.11
uniprot id: O61942
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0035.4
gene id: 6239:CELE_B0035.4
uniprot id: Q17435
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE Y74C10AL.2
gene id: 6239:CELE_Y74C10AL.2
uniprot id: Q9N2X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

6239:CELE Y47G6A.1
gene id: 6239:CELE_Y47G6A.1
uniprot id: Q9N3R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE Y47G6A.19
gene id: 6239:CELE_Y47G6A.19
uniprot id: H2L0D7
uniprot id: H2L0D8
names: Caution
names: Similarity
messages: Belongs to the peptidase M14 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R11D1.9
gene id: 6239:CELE_R11D1.9
uniprot id: Q21939
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

6239:CELE F15A2.1
gene id: 6239:CELE_F15A2.1
uniprot id: I2HA94
uniprot id: Q19470
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C25D7.7
gene id: 6239:CELE_C25D7.7
uniprot id: O17599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

6239:CELE D1054.14
gene id: 6239:CELE_D1054.14
uniprot id: Q18942
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

6239:CELE F09G8.2
gene id: 6239:CELE_F09G8.2
uniprot id: P34387
names: Similarity
messages: Belongs to the DNase II family.

6239:CELE F36G3.3
gene id: 6239:CELE_F36G3.3
uniprot id: Q7YX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE B0035.9
gene id: 6239:CELE_B0035.9
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE F25G6.5
gene id: 6239:CELE_F25G6.5
uniprot id: O16925
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

6239:CELE F31F4.12
gene id: 6239:CELE_F31F4.12
uniprot id: O17131
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y73B6BL.19
gene id: 6239:CELE_Y73B6BL.19
uniprot id: Q95XD1
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

6239:CELE T21G5.3
gene id: 6239:CELE_T21G5.3
uniprot id: P34689
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: First expressed during the L3-L4 stages of larval development, coinciding with germline proliferation.
messages: Interacts with csn-5; this may prevent glh-1 degradation induced by kgb-1 (PubMed:12435362, PubMed:17699606). Interacts with zyx-1 (PubMed:12435362). Interacts (via the N-terminal region containing the four CCHC zinc fingers) with pan-1 (PubMed:22342905). Interacts with kgb-1; this may promote glh-1 degradation by the proteasome (PubMed:17699606).
messages: Mortal germline (Mrt) phenotype in which there is a progressive decline in fertility with each generation at 25 degrees Celsius (PubMed:28533440). RNAi-mediated knockdown in a glh-4 mutant background results in smaller P-granules and irregular cytoplasmic localization of the P-granule component pgl-3 in embryos (PubMed:21402787). Quadruple RNAi-mediated knockdown with glh-4, pgl-1 and pgl-3 results in offspring that display 27-89% sterility, abnormal oocytes and do not have embryos in the uterus (PubMed:24746798). These sterile offspring still produce sperm (PubMed:24746798). Furthermore, these offspring may have compromised P-granule integrity as there is diffuse cytoplasmic localization of the P-granule component deps-1, which may cause germ cells to initiate somatic reprogramming (PubMed:24746798). RNAi-mediated knockdown in a double ced-1 and hpl-2 mutant background rescues the reduced somatic cell apoptotic cell defect in the ced-1 and hpl-2 double knockout (PubMed:27650246).
messages: Phosphorylated by kgb-1 (in vitro); this may be responsible for its degradation by the proteasome.
messages: Probable ATP-binding RNA helicase (PubMed:8415696). May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos (PubMed:21402787, PubMed:24746798). Plays a role in positively regulating the localization of pgl-1 to P-granules (PubMed:18234720). May play a role in transgenerational epigenetic inheritance (PubMed:28533440). May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246).
messages: perinuclear region

6239:CELE M01E11.6
gene id: 6239:CELE_M01E11.6
uniprot id: P91400
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6239:CELE F09A5.9
gene id: 6239:CELE_F09A5.9
uniprot id: A3FPK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C30B5.2
gene id: 6239:CELE_C30B5.2
uniprot id: Q18319
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Endosome membrane
messages: Involved in endosomal protein transport.

6239:CELE C47D12.6
gene id: 6239:CELE_C47D12.6
uniprot id: P52709
uniprot id: Q86D21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

6239:CELE C50B6.2
gene id: 6239:CELE_C50B6.2
uniprot id: O17687
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F27C1.7
gene id: 6239:CELE_F27C1.7
uniprot id: Q7JNG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

6239:CELE F25D1.4
gene id: 6239:CELE_F25D1.4
uniprot id: Q19777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE Y41D4B.7
gene id: 6239:CELE_Y41D4B.7
uniprot id: Q8WSN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F53H8.4
gene id: 6239:CELE_F53H8.4
uniprot id: Q20735
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane
messages: Sphingomyelin synthases (SM synthase or SMS) synthesize the sphingolipid sphingomyelin (SM) through transfer of the phosphatidyl head group of 1,2-diacyl-sn-glycero-3-phosphocholine (phosphatidylcholine, PC) on to the primary hydroxyl of ceramide (N-acylsphingoid base), yielding 1,2-diacyl-sn-glycerol (diacylglycerol, DAG) as a side product. Functions as a bidirectional lipid cholinephosphotransferases capable of converting PC and ceramide to SM and DAG and vice versa depending on the respective levels of ceramide and DAG as phosphocholine acceptors, respectively.

6239:CELE F46H6.1
gene id: 6239:CELE_F46H6.1
uniprot id: Q20496
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rho GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

6239:CELE ZC506.4
gene id: 6239:CELE_ZC506.4
uniprot id: A0A0K3ASV1
uniprot id: A0A0K3AWH7
uniprot id: A3FPK2
uniprot id: Q09630
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity).
messages: Membrane

6239:CELE T22D1.10
gene id: 6239:CELE_T22D1.10
uniprot id: Q9GZH2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Expressed in gonadal cells.
messages: Forms homohexameric rings. May form a dodecamer with ruvb-1 made of two stacked hexameric rings.
messages: Nucleus
messages: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development (PubMed:25437307). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (PubMed:25652260). Specifically, negatively controls the expression of ER homeostasis regulator ckb-2 in a cdc-48.1/2-dependent manner (PubMed:25652260).
messages: RNAi-mediated knockdown results in gonadal detachment during gonad migration (PubMed:25437307). RNAi-mediated knockdown upon tunicamycin-induced ER stress in a cdc-48.1 and/or cdc-48.2 mutant background (insensitive to tunicamycin-induced ER stress) restores the expression of ER homeostasis regulator, ckb-2 (PubMed:25652260).

6239:CELE C02B10.3
gene id: 6239:CELE_C02B10.3
uniprot id: O44443
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F28F8.1
gene id: 6239:CELE_F28F8.1
uniprot id: G5EG72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y57A10C.3
gene id: 6239:CELE_Y57A10C.3
uniprot id: O62488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE R10E12.1
gene id: 6239:CELE_R10E12.1
uniprot id: P34552
names: Developmental Stage
names: Function
messages: Expressed throughout development.
messages: Required for lin-12 degradation after it has been internalised in the vulval precursor cells.

6239:CELE C46H11.3
gene id: 6239:CELE_C46H11.3
uniprot id: P91167
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

6239:CELE F46B6.8
gene id: 6239:CELE_F46B6.8
uniprot id: Q20449
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

6239:CELE ZK328.1
gene id: 6239:CELE_ZK328.1
uniprot id: Q8WT44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C19 family.
messages: Binds Ca(2+).
messages: Cytoplasm
messages: Expressed in embryos and adults.
messages: Expressed in excretory cells, coelomocytes, head neurons, hypodermal cells, germ cells, oocytes, sperm and pharynx (at protein level).
messages: Nucleus
messages: RNAi-mediated knockdown causes embryonic lethality. Embryos have impaired cleavage after fertilization and a failure to form a functional paternal microtubule-organizing center (MTOC). Due to a lack of cytokinesis, embryos become multinucleated.
messages: Ubiquitin-protein hydrolase which cleaves ubiquitin from ubiquitinated proteins (PubMed:12006614, PubMed:11683918). Plays a role in embryo osmoregulation (PubMed:12006614). Probably by regulating osmosis, controls actin redistribution in the 1-cell embryos and thus actin-dependent processes such as cytokinesis and P-granules segregation (PubMed:12006614, PubMed:11683918). During the first embryonic mitotic division, involved in the formation of a functional microtubule organizing center provided by the male pronucleus (PubMed:11683918).
messages: microtubule organizing center

6239:CELE Y54G11A.3
gene id: 6239:CELE_Y54G11A.3
uniprot id: Q9XVZ6
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE F37C12.9
gene id: 6239:CELE_F37C12.9
uniprot id: P48150
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

6239:CELE B0348.4
gene id: 6239:CELE_B0348.4
uniprot id: A0A0K3ARR2
uniprot id: A0A0K3ARS4
uniprot id: A0A0K3AS74
uniprot id: A0A0K3AS85
uniprot id: A0A0K3AUL3
uniprot id: A0A0K3AUM3
uniprot id: A0A0K3AV83
uniprot id: A0A0K3AV97
uniprot id: A0A0K3AXK2
uniprot id: G5EBH0
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in most or all neurons with high expression in the head and tail ganglia and low expression in the motor neurons of the ventral cord. Expressed in the intestine (at protein level) (PubMed:10571227, PubMed:10571228). In males, expressed in vas deferens, spicule protractor muscles, diagonal muscles and a male-specific neuron (PubMed:15958491).
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion (PubMed:10571228). Plays a role in efficient egg laying and defecation (PubMed:10571227, PubMed:10571228, PubMed:24212673). Involved in axon regeneration after injury (PubMed:23072806). Plays a role in male mating behavior by regulating spicule insertion and sperm transfer (PubMed:15958491). By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch (PubMed:19730689). By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection (PubMed:19380113). During embryogenesis, may play a role in epidermal morphogenesis together with plc-1 (PubMed:18369461).
messages: Mutant worms are similar in size to the wild-type but animals are bloated with eggs due to defective egg laying with decreased body flexion and sluggish locomotion (PubMed:10571227, PubMed:10571228). They have defects in the posterior body contraction step of the defecation motor program and become sluggish in the presence of exogenous betaine (PubMed:24212673). Animals are resistant to aldicarb, a carbamate insecticide (PubMed:10571228). Simultaneous knockout of egl-8 and snf-3 results in uncoordinated, hypercontracted and paralyzed animals (PubMed:24212673). RNAi-mediated knockdown causes a defect in sperm transfer and a slight defect in spicule protrusion resulting in male infertility (PubMed:15958491). Ca(2+) transient increase and avoidance behavior are defective in response to nose touch but not to benzaldehyde (PubMed:19730689). nlp-29 expression is abrogated following fungal infection by D.coniospora but not following physical injury (PubMed:19380113). Causes a 1.6 fold increase in embryonic arrest in a plc-1 (tm753) mutant background (PubMed:18369461).
messages: Perikaryon
messages: Synapse
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
messages: adherens junction
messages: axon

6239:CELE F54C8.3
gene id: 6239:CELE_F54C8.3
uniprot id: P34441
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the APC4 family.
messages: Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells (PubMed:10749938, PubMed:12498686, PubMed:11134076, PubMed:17237515). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Negatively regulates ify-1 protein levels during meiosis I (PubMed:12498686). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
messages: The APC/C is probably composed of at least 12 subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3, such-1 and gfi-3.
messages: The C-terminus is specifically required for completion of oocyte meiotic divisions.

6239:CELE C02D5.4
gene id: 6239:CELE_C02D5.4
uniprot id: D7SFI3
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

6239:CELE F11C1.6
gene id: 6239:CELE_F11C1.6
uniprot id: Q19345
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nuclear hormone receptor family.
messages: Expressed in the epidermis, the developing somatic gonad, and a subset of other epithelial cells.
messages: First expressed post-fertilization and expression continues throughout embryogenesis to adulthood (PubMed:10772806). More highly expressed in embryos and L1 to L3 stage larvae than L4 larva and adults (PubMed:10772806). Highly expressed in hyp8-11 cells in the male tail tip during male tail tip morphogenesis but ceases by the late L4 larval stage of development (PubMed:21408209).
messages: Interacts with lin-39 (PubMed:15314147). Interacts with nob-1 (PubMed:15314147).
messages: Nucleus
messages: Orphan nuclear receptor and probable transcription activator, required during development (PubMed:10772806, PubMed:15314147). Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop (PubMed:21408209). Regulates vulval precursor cell (VPC) differentiation, in concert with homeobox protein lin-39 (PubMed:15314147). Involved in promoting embryogenesis, in concert with homeobox protein nob-1 (PubMed:15314147). May play a role in modulation of lifespan and immunity (PubMed:29748542).
messages: RNAi-mediated knockdown results in embryonic or larval lethality in the majority of animals (PubMed:10772806). RNAi-mediated knockdown results in embryos that do not survive due to failed epidermally mediated process of embryo elongation (PubMed:10772806). Of the animals that hatch, larvae display a squat body statue, referred to as a dumpy phenotype, have uncoordinated movements and posterior patterning defects (PubMed:10772806). Larvae also have anterior patterning defects such as kinked or notched noses (PubMed:10772806). Animals that progress to adulthood are sterile and vulvaless (PubMed:10772806). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in 33% of adult males (also known as the Lep phenotype) (PubMed:10772806, PubMed:21408209). Knockdown causes enhanced embryonic lethality on a nob-1 mutant background.
messages: Transcription up-regulated in response to intestinal colonization by probiotic Lactobacillus fermentum strain JDFM216 (PubMed:29748542).

6239:CELE F36D3.4
gene id: 6239:CELE_F36D3.4
uniprot id: O45462
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE F16B4.8
gene id: 6239:CELE_F16B4.8
uniprot id: A0A0K3ASE2
uniprot id: A0A0K3AXQ4
uniprot id: O44628
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.
messages: Required for intestinal cell division following the 16E cell stage of embryogenesis (PubMed:27104746). Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex (PubMed:27104746). Plays a role in male tail development, via regulation of the cell divisions of the ray precursor cell lineages, perhaps acting together with cell cycle regulators cyl-1, cdk-1, cyb-3, and cyd-1 (PubMed:27923661).
messages: Transiently expressed in the intestine during larval development (PubMed:27104746). Expressed in the intestine in L1 stage larvae, not expressed in L2 to L3 stage larvae, but is then again expressed in the gonad of L4 stage larvae (PubMed:27104746). Expressed in seam cells during larval development (PubMed:27923661). Broadly expressed throughout development in multiple male somatic tissues, including pharynx, ventral nerve cord, body muscles, diagonal muscles, and hypodermis (PubMed:27923661).
messages: Viable, but 85% of animals are sterile at 20 degrees Celsius (PubMed:27104746). Reduced number of intestinal cells in 1.5-fold stage embryos due to defective intestinal divisions and binuleations at the 16E cell stage of embryonic development (PubMed:27104746). Knockout with wee-1.3 RNAi suppresses the defect in intestinal cell divisions in the cdc-25.2 single mutant (PubMed:27104746). RNAi-mediated knockdown causes abnormal male tail morphology; this phenotype is suppressed by simultaneous RNAi-mediated knockdown of wee-1.3 (PubMed:27923661).

6239:CELE R10D12.14
gene id: 6239:CELE_R10D12.14
uniprot id: C6KRN1
names: Disruption Phenotype
names: Function
messages: Involved in negative regulation of early and late embryonic Notch signaling.
messages: Partially penetrant phenotypes when temperature elevated to 25 degrees Celsius which include embryonic lethality, reduced brood size, egg retention and an increased incidence of males.

6239:CELE C18C4.9
gene id: 6239:CELE_C18C4.9
uniprot id: Q18086
names: Developmental Stage
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Tissue Specificity
messages: Belongs to the globin family.
messages: By anoxia.
messages: Does not bind carbon monoxide (CO), nitric oxide (NO) or CN(-).
messages: Expressed at all developmental stages.
messages: Expressed in the head and tail neurons and nerve cord.
messages: May play a role as physiological sensor for oxygen via redox signaling and/or electron transport.

6239:CELE T28B8.4
gene id: 6239:CELE_T28B8.4
uniprot id: K7ZUR1
names: Similarity
messages: Belongs to the BLM10 family.

6239:CELE F44B9.1
gene id: 6239:CELE_F44B9.1
uniprot id: P34422
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell membrane
messages: Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.

6239:CELE R119.6
gene id: 6239:CELE_R119.6
uniprot id: O61707
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF4 family.
messages: Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein tbp-1, and a number of TBP-associated factors (TAFs) (By similarity). Interacts (via histone-fold domain) with oma-1 (via histone-fold domain) (PubMed:18854162). May also interact with oma-2 (PubMed:18854162). Interacts (via histone-fold domain) with taf-12 (via the histone-fold domain) (PubMed:18854162).
messages: Cytoplasm
messages: Expressed in one-, two- and four-cell embryos and through early morphogenesis (at protein level) (PubMed:11566890, PubMed:18854162). Also expressed in oocytes, and until at least 12-cell stage in embryos (PubMed:18854162).
messages: Nucleus
messages: RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890). The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890). Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced severely in embryos (PubMed:11566890). Abolishes expression of a range of genes, including let-858, rps-5, hsp16.2, pes-10, cki-2 and sur-5 (PubMed:11566890). RNAi-mediated knockdown in a Rieske iron-sulfur protein isp-1 mutant background abolishes lifespan extension, drastically reduces fertility, and abolishes induction of expression of glutathione S-transferase gst-4 (PubMed:24107417). Knockdown also significantly shortens lifespan in either tpk-1 or clk-1 mutant backgrounds (PubMed:24107417). Causes significant up-regulation of expression of the translation initiation factor eif-1, in a clk-1 mutant background (PubMed:30198021).
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-4 (By similarity). Essential for early embryonic development, probably acting via activating transcription initiation by RNA polymerase II, as part of the TFIID complex (PubMed:18854162, PubMed:11566890). In early embryos, but not oocytes, remains, presumably inactive, in the cytoplasm as a result of binding to oma-1 (PubMed:18854162). Upon degradation of oma-1, taf-4 is released and bound by taf-12, and the taf-4/12 heterodimer translocates to the nucleus and transcriptional repression is relieved (PubMed:18854162). Involved in lifespan extension in a manner dependent upon mitochondrial function (PubMed:24107417). Plays a role in modulating polyribosome formation (PubMed:30198021).
messages: The histone-fold domain mediates hetero-dimer protein-protein interactions.
messages: Throughout PMID:11566890, the gene name taf-5 is used instead of taf-4, based on an earlier nomenclature; readers should be aware to avoid confusion.

6239:CELE C13B9.4
gene id: 6239:CELE_C13B9.4
uniprot id: Q09460
uniprot id: S6FD44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Disrupted locomotion (unc); decreased speed, increased number of reversals and loss of mate searching behavior (PubMed:14551910, PubMed:22579613, PubMed:23143519). RNAi-mediated knockdown causes reduced expression of TGFbeta-like daf-7 in ASJ chemosensory neurons (PubMed:30024377).
messages: Expressed in both hermaphrodites and males at the L4 stage in the head, body wall muscle cells and tail.
messages: Expression was observed in the mechanosensory neuron pairs PLM, ALM, FLP, OLQD, and OLQV, the chemosensory neurons PHA, PHB, RMEV, the ring motor neurons RMED, and the pharyngeal interneuron pair I1 (PubMed:18390545). Expression in sensory neurons PHA, PQR and URY are responsible for mate searching behavior (PubMed:23143519). Expressed in AIY, RIM, RIA, and other neurons.
messages: G-protein coupled receptor for PDF neuropeptides (PubMed:18390545). Plays a role in responses to environmental signals, including chemicals and touch, and in modulating locomotory behaviors (PubMed:30024377, PubMed:18390545, PubMed:14551910, PubMed:22579613, PubMed:23143519, PubMed:23972393, PubMed:26113231). Capable of transducing signals via an adenylate cyclase acy-1 cAMP-dependent pathway (PubMed:23972393, PubMed:30024377). Required to regulate the sex-specific expression of TGFbeta-like daf-7 in the ASJ chemosensory neurons, perhaps acting via acy-1 (PubMed:30024377). Involved in modulating mate searching behavior independent of nutritional status (PubMed:18390545, PubMed:22579613, PubMed:23143519, PubMed:14551910). In the presence of food, plays a role in initiating and extending exploratory roaming behavior, perhaps acting in AIY, RIM, RIA, and other neurons, in opposition to 5-hydroxytryptamine (serotonin) signaling (PubMed:23972393). Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity (PubMed:18390545, PubMed:23764289). May play a role in circadian rhythms of locomotor activity (PubMed:26113231).
messages: G-protein coupled receptor which is activated by neuropeptides PDF-1 and PDF-2 (PubMed:18390545). Probably acts through the G-alpha(s) type of G proteins to elevate cAMP levels (PubMed:18390545).
messages: G-protein coupled receptor which is activated by neuropeptides PDF-1 and PDF-2; however, activation is lower compared to isoforms a and b (PubMed:18390545). Probably inhibits cAMP levels through the G-alpha(i/o) type of G proteins (PubMed:18390545).
messages: Membrane

6239:CELE Y54F10AM.4
gene id: 6239:CELE_Y54F10AM.4
uniprot id: Q8IA98
uniprot id: Q9BL02
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Asn-1149 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.
messages: Belongs to the CASP family.
messages: Belongs to the CUT homeobox family.
messages: Golgi apparatus membrane
messages: May be involved in intra-Golgi retrograde transport.
messages: Nucleus
messages: Probable DNA-binding regulatory protein involved in cell-fate specification.

6239:CELE T07H3.5
gene id: 6239:CELE_T07H3.5
uniprot id: O76609
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F54C1.3
gene id: 6239:CELE_F54C1.3
uniprot id: Q10665
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head (PubMed:17574230). PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells.
messages: Expressed maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed, mainly in Z2 and Z3 cells.
messages: Forms a heterotrimeric complex with the Polycomb proteins mes-2 and mes-3. Does not interact with mes-4. Interacts with nyfa-1 (PubMed:17574230).
messages: In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells.
messages: Nucleus
messages: RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region (PubMed:17574230). This ectopic expression of egl-5 in the head region is enhanced in a nfya-1 bp4 mutant background (PubMed:17574230).
messages: Repressed by GLD-1, which associates with the 3'-UTR of the mRNA and prevents its translation.

6239:CELE M6.1
gene id: 6239:CELE_M6.1
uniprot id: Q21067
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion.
messages: Expressed from late embryogenesis, and thereafter.
messages: Expressed in intestinal cells and at desmosomes in intestine and pharynx of the larva.
messages: Mutants exhibit mild dumpy phenotype and moderate defects in movement in adults.

6239:CELE K03D7.11
gene id: 6239:CELE_K03D7.11
uniprot id: Q9XUV1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE D2024.6
gene id: 6239:CELE_D2024.6
uniprot id: P34685
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

6239:CELE M60.5
gene id: 6239:CELE_M60.5
uniprot id: Q9GYM8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C33G8.7
gene id: 6239:CELE_C33G8.7
uniprot id: Q18391
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F36A4.6
gene id: 6239:CELE_F36A4.6
uniprot id: Q20091
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F15B10.1
gene id: 6239:CELE_F15B10.1
uniprot id: O44166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

6239:CELE Y46E12A.4
gene id: 6239:CELE_Y46E12A.4
uniprot id: Q1T6W8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

6239:CELE ZK652.9
gene id: 6239:CELE_ZK652.9
uniprot id: P34666
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

6239:CELE B0395.1
gene id: 6239:CELE_B0395.1
uniprot id: G5EDH8
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

6239:CELE C17E4.9
gene id: 6239:CELE_C17E4.9
uniprot id: Q93235
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Defecation defects.
messages: Non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). May also function in the peptidic vesicle transport pathway from the endoplasmic reticulum for the defecation behaviors.
messages: The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

6239:CELE C54H2.1
gene id: 6239:CELE_C54H2.1
uniprot id: G5EE38
uniprot id: Q86GI2
names: Similarity
messages: Belongs to the FAM102 family.

6239:CELE F56F4.3
gene id: 6239:CELE_F56F4.3
uniprot id: A0A7I9IA72
names: Subcellular Location Annotation
messages: Membrane

6239:CELE W03G11.3
gene id: 6239:CELE_W03G11.3
uniprot id: P49713
names: Function
names: Similarity
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.

6239:CELE Y41C4A.4
gene id: 6239:CELE_Y41C4A.4
uniprot id: Q9U2I0
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family.
messages: Defects in associative long-term memory (LTM) formation.
messages: Expressed widely, including in head neurons AFD, gustatory neurons ASE, the olfactory neurons AWC, and in the ASI sensory neurons, as well as in the intestine and gonads in hermaphrodites.
messages: Interacts with CREB-regulated transcription coactivator homolog crtc-1.
messages: Nucleus
messages: Plays a role in associative long-term memory (LTM) and learning.
messages: Plays a role in associative long-term memory (LTM) and learning; perhaps required at the time of acquisition and/or the consolidation phase of memory formation.
messages: RNAi-mediated knockdown positively modulates lifespan.
messages: Transcription factor (PubMed:12231504, PubMed:21331044). Transcriptional activity probably positively regulated by phosphorylation (PubMed:12231504, PubMed:27720609). Modulates expression of target genes, acting by binding to regulatory cAMP response elements (CRE) (PubMed:27720609, PubMed:12231504, PubMed:34260587). Acts downstream of the calcium-triggered CaMKK-CaMK1 signaling cascade, consisting of the protein kinase kinase ckk-1 and the protein kinase cmk-1 (PubMed:12231504, PubMed:27720609). Plays a role in learning and memory, feeding behavior, stress response, entry into the dauer stage and modulation of lifespan (PubMed:31413073, PubMed:21331044, PubMed:19035344, PubMed:27720609, PubMed:23013276, PubMed:34260587). Involved in commitment to the developmentally arrested larval state known as dauer, acting by positively regulating the expression of dauer-inhibiting TGF-beta-like daf-7 in the ASI neurons (PubMed:34260587). Plays a role in both associative and non-associative long-term memory (LTM) (PubMed:23013276, PubMed:31413073). Involved in modulating feeding behavior, acting by regulating transcription of tryptophan hydroxylase tph-1 in serotonergic ADF neurons (PubMed:19035344). Regulates transcription of genes involved in endoplasmic reticulum (ER) stress (PubMed:21331044). Involved in modulation of lifespan, in response to raised temperature, but independently of the heat-shock response pathway, acting by regulating transcription of FMRFamide-like neuropeptides flp-6 in the AFD neuron (PubMed:27720609, PubMed:21331044).
messages: Transcriptional activity is enhanced by phosphorylation (PubMed:12231504). Phosphorylated by cmk-1 (PubMed:12231504, PubMed:27720609).

6239:CELE C46A5.9
gene id: 6239:CELE_C46A5.9
uniprot id: G5EC23
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Expressed in embryos and the L1 larval stage (at protein level) (PubMed:11341844, PubMed:18828672). Expressed in embryos and adults, with lower levels in L1-L4 larvae (PubMed:9858614, PubMed:14629117).
messages: Interacts with daf-16/FOXO (PubMed:18828672). Interacts with deacetylase sir-2.1 (PubMed:21909281). Interacts with the 14-3-3 family proteins ftt-2 and par-5 (PubMed:21909281).
messages: Nucleus
messages: Phosphorylated at multiple serine residues (PubMed:11341844). Phosphorylation is developmentally regulated, occurring in embryos but not L1 larvae (PubMed:11341844). Phosphorylation may be cell-cycle-regulated (PubMed:11341844).
messages: RNAi-mediated knockdown causes 20-30% increase in lifespan (PubMed:18828672). Causes smaller brood size (50% of wild type) and lower hatching rate (21% vs. 99%) at 12 degrees Celsius (PubMed:18043729). Increases intestinal expression of skn-1 target genes, including gcs-1, gst-4 and gst-7; increase abolished in an skn-1 mutant background (PubMed:22568582). Substantially reduces enrichment of hcf-1 on the efl-1 promoter and enhances enrichment of daf-16 at sod-3 and mtl-1 promoters (PubMed:18828672). Two-fold reduction in the level of embryonic expression of sup-35 in a lin-35 mutant background (PubMed:19521497). Partial suppression of larval lethality in both lin-35;ubc-18 and lin-35;pha-1 mutant backgrounds and suppression of pharynx-unattached phenotypes in a pha-1 mutant background (PubMed:19521497).
messages: Transcriptional coregulator (PubMed:18828672). Involved in control of the cell cycle and in modulating mitotic histone phosphorylation (PubMed:18043729). Plays a role in modulating lifespan by regulating the transcriptional activity of daf-16/Forkhead box protein O, in concert with protein deacetylase sir-2.1/SIRT1, and perhaps acting independently of the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:18828672, PubMed:21909281). Negatively modulates responses to environmental stresses, including oxidative stress, heat stress, and exposure to heavy metals; acting via regulation of the transcription factors daf-16 and skn-1 (PubMed:18828672, PubMed:21909281, PubMed:22568582). May play a role in pharyngeal development via positive modulation of expression of sup-35 (PubMed:19521497).

6239:CELE W02A2.6
gene id: 6239:CELE_W02A2.6
uniprot id: Q9XUB3
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the rad21 family. Highly divergent.
messages: Chromosome
messages: Expressed in premeiotic and meiotic gonadal cells (PubMed:11390355, PubMed:25171895). Expressed in spermatocytes (PubMed:23401519).
messages: Nucleus
messages: Phosphorylated by air-2 in vitro.
messages: Plays a role in meiotic chromosome cohesion and segregation (PubMed:11390355, PubMed:25171895). Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II (PubMed:19574299). May also be required for repair of programmed meiotic double stranded breaks (PubMed:11390355). During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division (PubMed:23401519).
messages: RNAi-mediated knock-down results high embryonic lethality (PubMed:11390355). F1 worms have an extended lifespan, an increased incidence of males phenotype and improved survival to toxic oxidative stress (PubMed:11390355). Worms have defective meiotic chromosome cohesion and chromatid segregation (PubMed:12827206, PubMed:11390355).
messages: spindle pole

6239:CELE K08C7.2
gene id: 6239:CELE_K08C7.2
uniprot id: G5EDP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

6239:CELE T05B4.10
gene id: 6239:CELE_T05B4.10
uniprot id: O16419
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y48G1C.1
gene id: 6239:CELE_Y48G1C.1
uniprot id: Q9N3P1
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic granule
messages: Expressed in two cell, 4 cell and 300 cell embryos and in the primordial germ cells, Z2 and Z3 (PubMed:33438773). Expressed in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880). Expressed in germ cells of L4 larvae (PubMed:33231880).
messages: Expressed throughout the mitotic and meiotic regions of the germline and in oocytes.
messages: Involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and that guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33438773, PubMed:33231880). Not required for the biogenesis of 21U-RNAs (PubMed:33231880). May also be involved in gene silencing mediated by 22G-siRNAs (a class of 22 nucleotide endogenous small interfering RNAs (siRNAs) that possess a triphosphorylated guanine residue at the 5'-end) and 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end) (PubMed:33231880). Required for the biogenesis of secondary and tertiary 22G-siRNAs from many loci (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). May play a role in the production of 26G-siRNAs (PubMed:33231880). Plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33438773, PubMed:33231880). Together with the argonaut protein hrde-1, promotes the silencing of the DNA transposable element Tc1 (PubMed:33231880). Required for the formation of liquid-like condensates in the cytoplasm called Z granules, playing a role in maintaining their assembly, viscosity and morphology in adult germ cells, and localization in early embryos (PubMed:33438773, PubMed:33231880).
messages: May interact with pid-4, pid-5, app-1 and prmt-5.
messages: perinuclear region

6239:CELE Y40B1B.6
gene id: 6239:CELE_Y40B1B.6
uniprot id: Q9XWP6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavin monoamine oxidase family.
messages: Expressed throughout the development. Expressed in embryos, L1, L2, L3 and L4 larval stages and in adults.
messages: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor (PubMed:34329293). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). May be involved in H3 demethylation in mitotic cells including gut and embryonic cells (PubMed:34329293). Participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12411496). May act via the formation of a multiprotein complex that remodel or modify the chromatin (PubMed:12381669). Together with met-2, set-17 and set-26, required for transgenerational fertility (PubMed:24685137). Plays a role in developmental growth and lifespan regulation in response to ultraviolet-induced damage (PubMed:33046905).
messages: Nucleus
messages: Probably part of a large repressor complex (PubMed:12411496). Interacts with CoREST protein spr-1 (PubMed:12411496). Interacts with chromobox protein homolog hpl-1 (PubMed:26476455).
messages: Progressive loss of fertility and accumulation of histone H3 'Lys-4' dimethylation (H3K4me2) over generations (PubMed:24685137). Suppression of sel-12 mutant phenotypes, possibly by up-regulating hop-1 expression (PubMed:12411496).

6239:CELE C52E12.3
gene id: 6239:CELE_C52E12.3
uniprot id: Q18779
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Golgi apparatus membrane
messages: Involved in the import of UDP-glucuronic acid (UDP-GlcA), UDP-N-acetylgalactosamine (UDP-GalNAc) and UDP-galactose (UDP-Gal) from the cytoplasm into the Golgi lumen for the biosynthesis of glycoconjugates that play a pivotal role in development (PubMed:11259660). Involved in the synthesis of chondroitin sulfate and heparan sulfate proteoglycans (PubMed:11005858). Required for embryonic development (PubMed:9927677). Involved in vulva epithelium invagination and embryonic development (PubMed:9927677, PubMed:11259660). Involved in the directed migration of hermaphrodite-specific neurons (PubMed:24052309).

6239:CELE B0024.1
gene id: 6239:CELE_B0024.1
uniprot id: Q17417
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE H21P03.2
gene id: 6239:CELE_H21P03.2
uniprot id: Q9XTV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

6239:CELE T21H8.1
gene id: 6239:CELE_T21H8.1
uniprot id: Q94071
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the liprin family. Liprin-beta subfamily.
messages: Defective locomotion, reduced pumping rate and reduced brood size (PubMed:19290026). Defects in presynaptic and postsynaptic structures and functions in muscle cells (PubMed:19290026). Resistant to the acetylcholinesterase inhibitor aldicarb and to levamisole, an agonist for postsynaptic acetylcholine receptors in muscles (PubMed:19290026). Double knockout with the syd-2 mutant ju37 increases resistance to aldicarb and levamisole (PubMed:19290026).
messages: Expressed in pharyngeal muscle, particularly posterior bulb, adjacent to the dorsal and ventral cord (but not in ventral cord neurons), and in body wall muscles.
messages: Involved in the regulation of synaptic function at neuromuscular junctions (PubMed:19290026). Together with the liprin-alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse (PubMed:19290026). Does not seem to be required for neuronal development (PubMed:19290026). May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity).

6239:CELE C16A3.4
gene id: 6239:CELE_C16A3.4
uniprot id: Q18037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

6239:CELE C47E12.4
gene id: 6239:CELE_C47E12.4
uniprot id: Q18680
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Plays a role in intestinal development and subsequent normal secretory, digestive and absorption functions. Required for larval development.
messages: Cytoplasm
messages: Expressed from the embryonic stage of development to adulthood.
messages: Expressed in coelomocytes, the intestine and in the nervous system including the nerve cords and sensory neurons.

6239:CELE Y67D2.5
gene id: 6239:CELE_Y67D2.5
uniprot id: Q9BKR0
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

6239:CELE M117.1
gene id: 6239:CELE_M117.1
uniprot id: A0A061AE94
uniprot id: Q21538
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F54F11.3
gene id: 6239:CELE_F54F11.3
uniprot id: O02275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE C33G8.10
gene id: 6239:CELE_C33G8.10
uniprot id: Q18395
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE C01C10.4
gene id: 6239:CELE_C01C10.4
uniprot id: Q9NGJ7
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Clc family.
messages: Expressed throughout development.
messages: Membrane

6239:CELE K01G5.2
gene id: 6239:CELE_K01G5.2
uniprot id: G5EDE2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Causes ectopic up-regulation of transcription of specific genes, such as lin-39 and lag-2 (PubMed:16890929). Causes accumulation of double-stranded RNA transcripts (PubMed:29760282). Splicing defects (PubMed:29760282). Results in increased levels of spliced xbp-1 under basal conditions (PubMed:24715729). Increases survival in response to ER stress inducers tunicamycin or dithiothreitol (DTT), as compared to wild-type (PubMed:24715729). Knockout in a chromobox protein homolog hpl-1 mutant background has no effect on the distribution of monomethylated histone H3 'Lys-9' (H3K9me3) in chromatin (PubMed:26476455). Germline nuclei differ in size and morphology in a his-24 mutant background, probably as a result of altered chromatin compaction (PubMed:23028351). Causes defects in gonad elongation when grown at 25 degrees Celsius; phenotype exacerbated in an hpl-1 mutant background (PubMed:16905130). Causes vulva defects, infertility and larval lethality, in particular when grown at 25 degrees Celsius; exacerbated in various mutant backgrounds, such as hpl-1, or rcor-1 or his-24, or by simultaneous RNAi-mediated knockdown of lin-15A, or lin-9 or lin-35 (PubMed:26476455, PubMed:23028351, PubMed:16890929). Causes male tail defects in a his-24 mutant background (PubMed:23028351). Some knockout phenotypes are suppressed by simultaneous RNAi-mediated knockdown of histone-lysine N-methyltransferase set-2 (PubMed:17967446). RNAi-mediated knockdown causes sterility and vulval defects; sterility exacerbated by simultaneous RNAi-mediated knockdown of hpl-1. Defects in oocyte morphology, perhaps due to abnormal maturation (PubMed:11850401).
messages: Chromosome
messages: Expressed in embryos at about the 20-50 cell stage (PubMed:11850401, PubMed:16905130). Expression persists throughout development and into adulthood (PubMed:11850401). Also expressed at lower level in germ cells, developing oocytes and embryos starting at the two-cell stage, before the onset of zygotic transcription, suggesting that the protein is maternally inherited (PubMed:11850401). Expressed in hyp7 hypodermal cells and vulval precursor cells of larval L2 stage hermaphrodites (PubMed:19064713).
messages: Interacts with histone H3 when di-, or tri-methylated at 'Lys-27' (H3K27me2/me3), or tri-methylated at 'Lys-9' (H3K9me3) (PubMed:26476455, PubMed:23028351). Interacts with Tar DNA-binding protein homolog tdp-1; interaction may maintain localization of hpl-2 to gene bodies (PubMed:29760282). Interacts with histone H1 his-24, probably via interaction with hpl-1 (PubMed:22083954). Interacts with chromobox protein homolog hpl-1 (PubMed:22083954).
messages: May form homodimers (PubMed:16890929). Interacts (via chromo (shadow subtype) domain) with zinc finger protein lin-13 (via PLVPV motif); the interaction is direct and influences localization of hpl-2 to nuclear foci (PubMed:16890929).
messages: Nucleus
messages: Seems to be involved in transcriptional silencing in heterochromatin-like complexes (PubMed:11850401). Probably does not act as global transcriptional repressor, instead targeting a subset of genes (PubMed:23028351, PubMed:19064713, PubMed:22185090, PubMed:25467431). Involved in RNA processing mediated by Tar DNA-binding protein homolog tdp-1 (PubMed:29760282). Plays a role in linking epigenetic regulation with the innate immune response (PubMed:22083954). Involved in the endoplasmic reticulum (ER) stress response via modulation of the unfolded protein response (UPR), acting mainly through the IRE1-XBP1 pathway and perhaps, to a lesser extent, through the autophagy pathway (PubMed:24715729). May act in a common pathway with retinoblastoma-like protein homolog lin-35 and zinc finger protein lin-13 to influence the ER stress response in the intestine (PubMed:24715729). Plays a role in the formation of the vulva and in fertility, acting together with a CoREST-like complex, and chromobox protein homolog hpl-1 (PubMed:26476455, PubMed:16905130, PubMed:16890929, PubMed:11850401). Acting in concert with hpl-1 and histone H1 protein his-24, involved in reproduction, somatic gonad development, male tail development and vulval cell fate specification; perhaps as a result of modulating expression of Hox genes mab-5 and egl-5 (PubMed:23028351, PubMed:16905130, PubMed:16890929, PubMed:11850401, PubMed:19064713). In vulval cell fate specification may act by repressing transcription, of EGF family gene lin-3 in hypodermal hyp7, and of homeobox lin-39 in vulval precursor cells (VPC) (PubMed:19064713). Role in growth and somatic gonad development is antagonized by histone-lysine N-methyltransferase set-2/SET1 (PubMed:17967446). Required for larval development, acting redundantly with hpl-1 (PubMed:16905130). Plays a role in regulation of the developmentally arrested larval state known as dauer, longevity, and lipid metabolism (PubMed:22185090).

6239:CELE ZK430.7
gene id: 6239:CELE_ZK430.7
uniprot id: Q23494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

6239:CELE B0041.4
gene id: 6239:CELE_B0041.4
uniprot id: O02056
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

6239:CELE C12D8.1
gene id: 6239:CELE_C12D8.1
uniprot id: Q17935
uniprot id: Q17936
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C34H3.1
gene id: 6239:CELE_C34H3.1
uniprot id: Q9N5X7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE M70.4
gene id: 6239:CELE_M70.4
uniprot id: Q688B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

6239:CELE T01C8.5
gene id: 6239:CELE_T01C8.5
uniprot id: Q22067
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Biosynthesis of L-glutamate from L-aspartate (PubMed:29649217). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system (PubMed:29649217).
messages: Cytoplasm
messages: Expressed in all somatic tissues including the nervous system.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6239:CELE T27D1.1
gene id: 6239:CELE_T27D1.1
uniprot id: Q09637
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclophilin-type PPIase family.
messages: Co-expressed with pdi-1 in the syncytial hypodermis.
messages: Expression significantly up-regulated in the middle of the L3 (22 hours) and L4 (26 hours) larval stages.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens.

6239:CELE Y102A5C.28
gene id: 6239:CELE_Y102A5C.28
uniprot id: Q9XX85
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein str family.
messages: Cell membrane
messages: Expressed in the ADL chemosensory neurons.
messages: Lack of sensitivity of ADL neurons to N,N-diethyl-meta-toluamide (DEET) with no effect on average pause length of worms following DEET exposure in contrast to wild-type worms which show a marked increase (PubMed:30258230). Does not affect AWC neuron activity in response to DEET (PubMed:30258230).
messages: Mediates sensitivity to N,N-diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide.
messages: Probable G-protein coupled receptor.
messages: The naturally occurring CB4856 strain isolated in Hawaii carries a deletion of str-217 and is resistant to N,N-diethyl-meta-toluamide (DEET).

6239:CELE Y57A10A.10
gene id: 6239:CELE_Y57A10A.10
uniprot id: Q9NA75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Potassium channel that mediates transmembrane potassium transport (PubMed:27698420). Might be required for maintenance of rapid intracellular calcium release (By similarity). May act as a counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27698420).

6239:CELE T24A6.9
gene id: 6239:CELE_T24A6.9
uniprot id: A0A131MBQ7
uniprot id: A0A131MCM3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F08G12.4
gene id: 6239:CELE_F08G12.4
uniprot id: Q19213
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VHL family.
messages: Increased mortality induced by B.thuringiensis pore-forming toxins Cry21A and Cry21B (PubMed:20011506). Increased mortality and sensitivity to paralysis induced by enteropathogenic E.coli infection (PubMed:16091039). Increased mortality upon heat stress (PubMed:12686697). RNAi-mediated knockdown causes an enhanced resistance to polyglutamine or amyloid-beta-mediated paralysis and an increase in adult life span.
messages: Interacts with hif-1 (hydroxylated on 'Pro-621'); the interaction induces hif-1 degradation (PubMed:11595184). May be a component of the cullin E3 ubiquitin ligase complex (By similarity).
messages: Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%) (PubMed:11595184). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size (PubMed:12686697, PubMed:19372390, PubMed:22396654). Mediates resistance to enteropathogenic E.coli (PubMed:16091039). Mediates susceptibility to B.thuringiensis pore-forming toxins (PubMed:20011506). Not involved in P.aeruginosa susceptibility (PubMed:20865124).

6239:CELE T28H11.6
gene id: 6239:CELE_T28H11.6
uniprot id: Q23058
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE C53C7.1
gene id: 6239:CELE_C53C7.1
uniprot id: Q6EUU1
uniprot id: Q9XXU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

6239:CELE F40F9.6
gene id: 6239:CELE_F40F9.6
uniprot id: J7SA48
uniprot id: Q20239
uniprot id: Q9U3F8
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

6239:CELE T23D8.2
gene id: 6239:CELE_T23D8.2
uniprot id: Q9XVI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE F08C6.3
gene id: 6239:CELE_F08C6.3
uniprot id: G5EFV8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545). Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843). Important for neuronal function (PubMed:27191843).
messages: Belongs to the VPS52 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of vps-51, vps-52, vps-53 and vps-54. Within the complex interacts with vps-53 and vps-54 (PubMed:21613545). Interacts with the small GTPases rab-6.1 and rab-6.2 (PubMed:21613545).
messages: Enlarged lysosomes (PubMed:21613545). Reduced brood size (PubMed:21613545). Egg-laying defect, slow, but coordinated locomotion, and reduced levels of unprocessed and processed cargo in the motor neuron axon of the dorsal nerve cord (PubMed:27191843).
messages: Perikaryon
messages: Ubiquitously expressed, with particularly strong expression in neuronal cells (PubMed:21613545). Specifically expressed in head and tail neurons and in the pharynx and ventral cord motor neurons (PubMed:27191843).
messages: perinuclear region
messages: trans-Golgi network

6239:CELE W03D8.5
gene id: 6239:CELE_W03D8.5
uniprot id: Q1XFY6
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE ZK1128.1
gene id: 6239:CELE_ZK1128.1
uniprot id: Q09644
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

6239:CELE ZK1053.5
gene id: 6239:CELE_ZK1053.5
uniprot id: G5EEQ3
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE R160.7
gene id: 6239:CELE_R160.7
uniprot id: Q9TZD0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the lst-2 family.
messages: Causes ectopic vulval induction.
messages: Expressed in vulval precursor cells (VPCs).
messages: Highly expressed in all 6 vulval precursor cells (VPCs). At the time of inductive signaling, expression forms a gradient in response to inductive signal: expression is low in P6.p, intermediate in P5.p and P7.p and undiminished in P3.p, P4.p, and P8.p. Later, expression becomes strong again in P5.p and P7.p.
messages: Negative regulator of epidermal growth factor receptor (EGFR) signaling.

6239:CELE Y110A7A.3
gene id: 6239:CELE_Y110A7A.3
uniprot id: Q9N587
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15280391, PubMed:15990870, PubMed:20027209). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209). Involved in nAChR sensitivity to nicotine and levamisole (PubMed:15280391, PubMed:15990870).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Component of nicotinic acetylcholine receptor (PubMed:15990870, PubMed:20027209). In muscles, composed of 2 non-alpha subunits lev-1 and unc-29, and 3 alpha subunits unc-38, unc-63 and lev-8 (PubMed:15990870). In cholinergic motoneurons, composed of 2 non-alpha subunits acr-2 and acr-3, and 3 alpha subunits unc-38, unc-63 and acr-12 (PubMed:20027209). Interacts with lev-10 (PubMed:21252855).
messages: Expressed in body wall muscles, in vulval muscles and in neurons.
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a resistance to nicotine-mediated paralysis.

6239:CELE C50F4.2
gene id: 6239:CELE_C50F4.2
uniprot id: Q27483
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

6239:CELE F17A9.3
gene id: 6239:CELE_F17A9.3
uniprot id: O16213
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE B0025.4
gene id: 6239:CELE_B0025.4
uniprot id: Q8WQC3
names: Similarity
messages: Belongs to the EAF6 family.

6239:CELE ZK1127.4
gene id: 6239:CELE_ZK1127.4
uniprot id: Q23402
names: Similarity
messages: Belongs to the BCP1 family.

6239:CELE T24H10.1
gene id: 6239:CELE_T24H10.1
uniprot id: P52652
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity).
messages: Nucleus

6239:CELE F37C12.13
gene id: 6239:CELE_F37C12.13
uniprot id: Q20128
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE T21C9.12
gene id: 6239:CELE_T21C9.12
uniprot id: Q22647
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIM50 family.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

6239:CELE Y41C4A.9
gene id: 6239:CELE_Y41C4A.9
uniprot id: Q9U2I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

6239:CELE Y17G7B.13
gene id: 6239:CELE_Y17G7B.13
uniprot id: Q9XXI1
names: Domain
names: Function
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

6239:CELE T20H4.4
gene id: 6239:CELE_T20H4.4
uniprot id: Q22618
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Can prevent somatic transgenes from inducing gene silencing via the RNA interference (RNAi) pathway. This may occur due to A-to-I editing of transgene-derived dsRNA, preventing transgene RNAi.
messages: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375). Acts primarily on non-coding regions of protein-coding genes including introns and untranslated regions (UTR) (PubMed:28925356, PubMed:25373143). Required for normal chemotaxis (PubMed:12426375, PubMed:14657490). Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis (PubMed:28925356). Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143). Not required for RNA interference (PubMed:12419225). Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).
messages: Cytoplasm
messages: Highest expression observed in the embryo. Levels decrease dramatically after embryogenesis, remain relatively constant during larval stages and increase again at the onset of adulthood.
messages: Interacts with A-to-I RNA editing regulator adr-1 (PubMed:24508457). Interacts with adbp-1; the interaction facilitates adr-2 nuclear localization (PubMed:18780728).
messages: Nucleus

6239:CELE ZK430.2
gene id: 6239:CELE_ZK430.2
uniprot id: Q23493
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

6239:CELE C26E6.11
gene id: 6239:CELE_C26E6.11
uniprot id: Q18218
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

6239:CELE ZK809.7
gene id: 6239:CELE_ZK809.7
uniprot id: Q23601
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.

6239:CELE M04G12.1
gene id: 6239:CELE_M04G12.1
uniprot id: P92004
uniprot id: Q9XVK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

6239:CELE ZK1128.8
gene id: 6239:CELE_ZK1128.8
uniprot id: Q86D99
uniprot id: Q9XVX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

6239:CELE T27B7.2
gene id: 6239:CELE_T27B7.2
uniprot id: O16663
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F22D6.12
gene id: 6239:CELE_F22D6.12
uniprot id: G5EBK7
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F54G8.5
gene id: 6239:CELE_F54G8.5
uniprot id: Q03602
names: Similarity
messages: Belongs to the patched family.

6239:CELE R09E10.5
gene id: 6239:CELE_R09E10.5
uniprot id: Q21874
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC455.3
gene id: 6239:CELE_ZC455.3
uniprot id: Q23333
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C54D1.6
gene id: 6239:CELE_C54D1.6
uniprot id: Q18825
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abnormalities in vulval development due to incorrect cell fate specification, resulting in the following phenotypes, multivulva (Muv), protruding vulva (Pvl) and egg laying defective (Egl) (PubMed:9716532, PubMed:11063687, PubMed:11560894, PubMed:12441291). Mutants also show defects in Q neuroblast migration, uncoordinated movement (Unc) and reduced superoxidase dismutase levels (PubMed:15905404). Mutants can be rescued by wrm-1 and hmp-2 when expressed from the bar-1 promoter (PubMed:11560894). Double knockout with dpy-22 result in reduced body length, male tail morphology abnormalities (Mab) and dauer induction (PubMed:12441291). RNAi-mediated knockdown in the intestine decreases E.faecium-mediated protection against S.enterica infection (PubMed:35263319).
messages: Alleles mu63 and mu349 were originally reported (PubMed:9834184) as the mutations L130F and Q147STOP respectively. This is in conflict with WormBase and more recent literature (PubMed:15282167) which is represented in this entry.
messages: Belongs to the beta-catenin family.
messages: Cell junction
messages: Cytoplasm
messages: Detected throughout development from L1 to L4 and during adulthood (PubMed:15282167). Expressed in P3.p to P8.p vulval precursor cells in the late L1 and early L2 larval stage (PubMed:9716532). Not expressed in vulval precursor cells P1.p, P2.p, P9.p, P10.p or P11.p in the mid-L3 larval stage (PubMed:9716532). Expressed in other postembryonic cells including seam cells (PubMed:9716532).
messages: Expressed in body wall muscle cells, hypodermal seam cells, gonad sheath cells and vulval precursor cells.
messages: Interacts with apr-1 (PubMed:11560894). Interacts with axl-1 (PubMed:17601533). Interacts with daf-16 (PubMed:15905404). Interacts with lin-23 (PubMed:15820693). and. Interacts with pop-1 (via acidic region in N-terminus 1-44) (PubMed:10952315, PubMed:11560894). Interacts (via ARM repeats) with pry-1 (PubMed:12023307).
messages: Membrane
messages: Nucleus
messages: Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development (PubMed:10952315). Functions as a transcriptional activator but is dependent on the interaction with pop-1 (PubMed:10952315). Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses (PubMed:15820693). Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling (PubMed:9834184, PubMed:15905404). Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction (PubMed:9716532, PubMed:9834184, PubMed:11063687, PubMed:11560894, PubMed:12441291, PubMed:15905404). Functionally redundant to wrm-1 and hmp-2 (PubMed:11560894). In the intestine, plays a role in probiotic-mediated protection against infections by pathogens such as S.enterica (PubMed:35263319).

6239:CELE B0464.4
gene id: 6239:CELE_B0464.4
uniprot id: Q03562
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 2 family.
messages: Cytoplasm
messages: Endothelial cells.
messages: Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis (PubMed:12944392, PubMed:10924467). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-4 and bre-5 (PubMed:12944392, PubMed:10924467). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796). Has a role in determining brood size (PubMed:12944392, PubMed:10924467).
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein. Mutants also have reduced brood sizes at only 17% of wild-type N2.

6239:CELE F32A11.2
gene id: 6239:CELE_F32A11.2
uniprot id: G5EGG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

6239:CELE T05E11.4
gene id: 6239:CELE_T05E11.4
uniprot id: A0A061AD57
uniprot id: Q22236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOP6A family.
messages: Nucleus
messages: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.

6239:CELE M03E7.1
gene id: 6239:CELE_M03E7.1
uniprot id: Q21500
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE B0393.4
gene id: 6239:CELE_B0393.4
uniprot id: Q17493
names: Similarity
messages: Belongs to the maelstrom family.

6239:CELE F35C8.6
gene id: 6239:CELE_F35C8.6
uniprot id: Q20025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
messages: Expressed in the intestinal wall, the spermatheca, and the pharynx.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
messages: cytoskeleton

6239:CELE F23F1.8
gene id: 6239:CELE_F23F1.8
uniprot id: O17071
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

6239:CELE R04A9.2
gene id: 6239:CELE_R04A9.2
uniprot id: Q21691
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei (PubMed:18653886). Required for exogenous RNAi-induced H3K27 methylation (PubMed:26365259).

6239:CELE T22E5.5
gene id: 6239:CELE_T22E5.5
uniprot id: Q27371
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.

6239:CELE Y66D12A.15
gene id: 6239:CELE_Y66D12A.15
uniprot id: Q95PZ4
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

6239:CELE ZC116.2
gene id: 6239:CELE_ZC116.2
uniprot id: Q23240
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).
messages: Mitochondrion intermembrane space

6239:CELE R10D12.17
gene id: 6239:CELE_R10D12.17
uniprot id: Q7YWV5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T09E11.1
gene id: 6239:CELE_T09E11.1
uniprot id: O02304
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE B0399.1
gene id: 6239:CELE_B0399.1
uniprot id: G5ED53
uniprot id: G5EER9
uniprot id: G5EEZ9
uniprot id: G5EFI1
uniprot id: Q8I4D2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y116A8C.12
gene id: 6239:CELE_Y116A8C.12
uniprot id: Q9U2S4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

6239:CELE F44C8.3
gene id: 6239:CELE_F44C8.3
uniprot id: O16360
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F35G8.1
gene id: 6239:CELE_F35G8.1
uniprot id: Q20067
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

6239:CELE D1081.2
gene id: 6239:CELE_D1081.2
uniprot id: Q18955
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in muscle, varying with age, decreasing twofold during the first week of adulthood.
messages: Mutants usually hatch and appear normal in early L1, but become progressively paralyzed later during L1 (PubMed:17142668). Complete larval lethal, typically at late L1 or early L2 (PubMed:17142668). Abnormal bodywall and egg-laying muscle in hermaphrodites, but with no obvious abnormality of pharyngeal muscle or other cell types (PubMed:17142668). Five percent of the progeny from hlh-1, unc-120 double heterozygous parents exhibit partial absence of bodywall muscle and reduced expression of myosin myo-3 (PubMed:17142668). RNAi-mediated knockdown causes a low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hlh-1 or hnd-1 mutant background (PubMed:15892873). RNAi-mediated knockdown causes those embryos that survive to hatching to become uncoordinated, dumpy larvae (PubMed:15892873). RNAi-mediated knockdown causes abnormalities in muscle, including: altered mitochondrial morphology at day 6 of adulthood, two-fold to five-fold down-regulation of transcript levels at day 7 and significant increase in the number of autophagic vesicles (PubMed:29314608). RNAi-mediated knockdown causes a reduction in average lifespan by 16% (PubMed:29314608). RNAi-mediated knockdown on a daf-2 mutant background causes a dramatic decrease in physical performance at day 18 (PubMed:29314608).
messages: Nucleus
messages: Transcription factor (By similarity). Regulates myogenesis, in cooperation with transcription factors hlh-1 and hnd-1 (PubMed:15892873, PubMed:17142668). Required for maintenance of muscle in adulthood (PubMed:29314608).

6239:CELE C33H5.12
gene id: 6239:CELE_C33H5.12
uniprot id: Q18409
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Extensively phosphorylated on serine residues in the RS domain.
messages: Nucleus
messages: Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood.
messages: RNA-mediated interference (RNAi) of rsp-5 and rsp-6 result in fertile animals that exhibit excessive sperm and delayed oocyte production, and sterile animals that develop morphological abnormalities of somatic gonads. Rsp-2/rsp-6 RNAi caused severe abnormalities in somatic gonad structures and in some cases animals were arrested or dead at the larval stage.

6239:CELE F41H10.6
gene id: 6239:CELE_F41H10.6
uniprot id: Q20296
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Binds 3 Zn(2+) ions per subunit.
messages: Nucleus
messages: Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).

6239:CELE K12H4.8
gene id: 6239:CELE_K12H4.8
uniprot id: P34529
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Dicer subfamily.
messages: Component of the ERI/DICER complex at least composed of dcr-1, rrf-3 and eri-1 (Probable). Interacts with pir-1 (PubMed:16439208, PubMed:33378643).
messages: Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable). Involved in cleaving dsRNA in the RNAi pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307). Involved in innate immunity through its role in small RNA processing.
messages: RNAi-mediated knockdown in a cps-6 mutant background reduces the number of DNA breaks in embryonic cells undergoing apoptosis.
messages: The avoidance behavior is transgenerationally inherited, and thus progeny display this same aversion despite never been exposed to this pathogenic bacteria.
messages: tDCR-1 acts as a deoxyribonuclease (DNase) initiating DNA fragmentation during apoptosis, upstream of nucleases cps-6, crn-2 and nuc-1.

6239:CELE K11E4.6
gene id: 6239:CELE_K11E4.6
uniprot id: B1Q258
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE T08G2.3
gene id: 6239:CELE_T08G2.3
uniprot id: Q22347
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: By serotonin.
messages: Expressed in the epidermis and intestine.
messages: Homotetramer.
messages: Mitochondrion matrix
messages: This enzyme is specific for acyl chain lengths of 4 to 16.

6239:CELE M04G12.2
gene id: 6239:CELE_M04G12.2
uniprot id: P92005
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C08E8.1
gene id: 6239:CELE_C08E8.1
uniprot id: O62039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE Y116A8C.25
gene id: 6239:CELE_Y116A8C.25
uniprot id: A0A0K3AUF9
uniprot id: A0A0K3AV43
uniprot id: A0A0K3AXF0
uniprot id: Q9U2U7
names: Similarity
messages: Belongs to the fructosamine kinase family.

6239:CELE ZC395.10
gene id: 6239:CELE_ZC395.10
uniprot id: Q23280
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the p23/wos2 family.
messages: Co-chaperone for hsp90/daf-21 (PubMed:20880838). Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures (PubMed:25830239).
messages: Expressed from embryo to adulthood.
messages: Expressed in anterior and posterior neurons including ASE, AWC, ASI and ADL amphids and phasmid sensory neurons, peripheral neurons and ventral cord motorneurons. Additionally expressed in body wall muscle, pharynx, vulva, germ cells and intestine.
messages: Resistant to oxidative and heat stress. At increased temperatures, there is increased longevity and an increased propensity of larvae to form dauer. At decreased temperatures, lifespan is shorter. Defective chemotaxis in response to toxins.

6239:CELE R01H10.3
gene id: 6239:CELE_R01H10.3
uniprot id: Q21624
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Asymmetrically expressed in Q neuroblasts during larval development. Highly expressed at the leading edge of migrating Q neuroblasts.
messages: Belongs to the WD repeat coronin family.
messages: Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts.
messages: cytoskeleton

6239:CELE C41C4.10
gene id: 6239:CELE_C41C4.10
uniprot id: A0A131MBC0
uniprot id: Q5FC79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrial amino-acid transporter.
messages: Mitochondrion membrane

6239:CELE M18.5
gene id: 6239:CELE_M18.5
uniprot id: Q21554
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DDB1 family.
messages: Cytoplasm
messages: Expressed at high levels in the spermatheca of adult hermaphrodites.
messages: Expressed in proliferating larval blast cells including seam cells in the lateral hypodermis, P cells in the ventral hypodermis, and intestinal cells. Within the P cell lineage expression levels correlate with the proliferative state, being low in newly hatched larvae and then increasing in L1 as P cells begin to proliferate. Not expressed in the adult cells of the P lineage which are postmitotic. Also expressed in some non-proliferating cells such as the lateral hyp7 hypodermal cells, rectal gland and epithelial cells, and a subset of neuronal cells in the head and tail regions.
messages: Interacts with cdt-1 and cul-4.
messages: Nucleus
messages: Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division.

6239:CELE Y69A2AR.3
gene id: 6239:CELE_Y69A2AR.3
uniprot id: Q95XG6
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

6239:CELE R02C2.6
gene id: 6239:CELE_R02C2.6
uniprot id: Q86S44
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE W01G7.3
gene id: 6239:CELE_W01G7.3
uniprot id: Q9XVH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).
messages: Nucleus

6239:CELE E01A2.7
gene id: 6239:CELE_E01A2.7
uniprot id: Q966L1
names: Similarity
messages: Belongs to the paraoxonase family.

6239:CELE F44D12.4
gene id: 6239:CELE_F44D12.4
uniprot id: Q20393
names: Similarity
messages: Belongs to the GIPC family.

6239:CELE ZC334.2
gene id: 6239:CELE_ZC334.2
uniprot id: Q9XUI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE R05D3.11
gene id: 6239:CELE_R05D3.11
uniprot id: P34544
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Chromosome
messages: Cytoplasm
messages: Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3 (PubMed:20107519, PubMed:22939621). This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9' (PubMed:22939621). Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development (PubMed:17634190). Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish between the partnerless male X chromosome and asynapsed chromosomes thereby shielding the lone X from inappropriate activation of an apoptotic program (PubMed:21909284). Operates redundantly with set-25 to position chromatin at the nuclear periphery (PubMed:22939621). Required for small-RNA-induced H3K9 methylation (PubMed:26365259). Together with set-25, protects and stabilizes repeat-rich genomic regions by suppressing transcription-induced replication stress through methylation of H3K9 (PubMed:27668659). Together with spr-5, required for transgenerational fertility (PubMed:24685137).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Induced vulval precursor cells in the absence of lin-15A (PubMed:15990876). Multi-vulval phenotype is apparent when grown at 24.5 degrees Celsius in the absence of lin-61 and when grown at 20 degrees Celsius in the absence of hpl-2 or met-1 (PubMed:17634190, PubMed:21437264). Reduced lamin interaction of chromosome arms in the absence of set-25 (PubMed:22939621). Increased apoptosis and increased occurrence of the recombination checkpoint XO germ lines (PubMed:21909284). High incidence of endomitotic oocytes (PubMed:20107519). In spr-5 null mutants, accelerates the progressive sterility over generations, which is seen in spr-5 mutants with complete sterility achieved by generation 2 (PubMed:24685137).
messages: Nucleus

6239:CELE F32H5.5
gene id: 6239:CELE_F32H5.5
uniprot id: P91994
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE ZK507.6
gene id: 6239:CELE_ZK507.6
uniprot id: P34638
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Expressed in the cell lineages ABarp, C and E as well as the NSM neuroblasts.
messages: Homozygous mutants are not viable. Partial loss-of-function mutation bc416 causes cell division defects with a reduction in the number of dividing NSM neuroblasts and some embryonic lethality.
messages: Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis.

6239:CELE Y39C12A.7
gene id: 6239:CELE_Y39C12A.7
uniprot id: Q9U2L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F11C7.4
gene id: 6239:CELE_F11C7.4
uniprot id: Q19350
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZK686.3
gene id: 6239:CELE_ZK686.3
uniprot id: P34669
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST3/OST6 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6239:CELE F21A3.11
gene id: 6239:CELE_F21A3.11
uniprot id: H2FLJ4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

6239:CELE F22E5.6
gene id: 6239:CELE_F22E5.6
uniprot id: O16711
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE Y71F9AL.1
gene id: 6239:CELE_Y71F9AL.1
uniprot id: Q9N4H1
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

6239:CELE F26D2.14
gene id: 6239:CELE_F26D2.14
uniprot id: Q9XV58
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C50C3.2
gene id: 6239:CELE_C50C3.2
uniprot id: P34367
names: Similarity
messages: Belongs to the spectrin family.

6239:CELE B0281.5
gene id: 6239:CELE_B0281.5
uniprot id: H2KY83
uniprot id: O16612
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE F54E7.2
gene id: 6239:CELE_F54E7.2
uniprot id: P49196
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

6239:CELE F20C5.1
gene id: 6239:CELE_F20C5.1
uniprot id: A5JYS4
uniprot id: F5GU97
uniprot id: L8EC33
uniprot id: Q867X0
uniprot id: X5LVA3
uniprot id: X5M5W8
uniprot id: X5M907
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.
messages: Expressed at all developmental stages.
messages: Expressed in head and tail neurons. Also detected in the central nerve cord and motor neurons.
messages: Nucleus
messages: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:17188026). Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells (By similarity).
messages: RNAi-mediated knockdown results in increased sensitivity to gamma irradiation.
messages: Weak activity relative to mammalian poly(ADP-ribose) glycohydrolase orthologs.

6239:CELE B0416.5
gene id: 6239:CELE_B0416.5
uniprot id: Q11073
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZC513.4
gene id: 6239:CELE_ZC513.4
uniprot id: Q23360
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE ZC482.6
gene id: 6239:CELE_ZC482.6
uniprot id: O18277
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C01B12.3
gene id: 6239:CELE_C01B12.3
uniprot id: O17206
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE M01F1.5
gene id: 6239:CELE_M01F1.5
uniprot id: Q21455
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in the intestine and sheath glial cells.
messages: H(+)-myo-inositol cotransporter.
messages: In contrast to family members hmit-1.1 and hmit-1.2, it is not induced by hyperosmotic stress.
messages: Perikaryon

6239:CELE B0310.3
gene id: 6239:CELE_B0310.3
uniprot id: Q10939
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C47D12.3
gene id: 6239:CELE_C47D12.3
uniprot id: Q18666
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

6239:CELE F43C9.4
gene id: 6239:CELE_F43C9.4
uniprot id: G5EF33
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abnormal migration of QR neuroblast lineage cells and BDU interneurons (PubMed:10412978, PubMed:22293500, PubMed:26022293). QR neuroblast descendants QR.paa and QR.pap irregularly migrate towards the posterior side of the body axis while QR.ap descendants fail to migrate towards the head and remain in the central body region or migrate towards the tail (PubMed:10412978). Irregular AQR neuron morphology and polarity during migration in larva at the L4 stage (PubMed:26022293, PubMed:27780040). Loss of F-actin at the leading edge of AQR neurons and as a result AQR neurons do not extend the lamellipodium and thus fail to translocate the cell body towards the anterior of the body leading to posteriorly positioned AQR neurons (PubMed:27780040).
messages: Cell membrane
messages: Expressed from embryogenesis to adulthood (PubMed:10412978). First expressed in the anterior region of comma stage embryos (PubMed:10412978). During embryogenesis, expressed in pharyngeal, hypodermal and neuronal precursors in the anterior body region (PubMed:10412978). During larval development, expressed in the pharyngeal-intestinal valve cells and neurons in the retrovesicular ganglion and the ventral cord (PubMed:10412978). Expressed in migrating QR neuroblasts with higher expression in migrating QR.a/ap cells than QR.p/pa cells (PubMed:23784779).
messages: Expressed in pharyngeal-intestinal valve cells and ventral cord neurons.
messages: Interacts with abl-1 (via SH2 and SH3 domains); the interaction is direct. Interacts with sem-5; the interaction is direct.
messages: Perikaryon
messages: Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development (PubMed:10412978, PubMed:8898225, PubMed:15750187, PubMed:22293500, PubMed:23784779, PubMed:26022293, PubMed:27780040). Associates with and recruits the downstream components tyrosine kinase abl-1 and the tyrosine kinase adapter protein sem-5 to the leading edge of migrating Q neuroblasts and their descendants to activate signaling through the two parallel wve-1 and wsp-1 pathways, respectively, and direct migration along the anteroposterior body axis (PubMed:27780040). Involved in cytoskeleton dynamics regulating the organization of the actin cytoskeleton at the leading edge of migrating cells to ensure correct Q cell polarity and promote migration (PubMed:23784779, PubMed:27780040). Role in cytoskeleton organization may be by activation of the wve-1 and wsp-1 pathways which recruit the Arp2/3 complex to the leading edge of migrating cells (PubMed:27780040). Plays a role in regulating the asymmetric distribution of the actin cytoskeleton-binding protein cor-1 in Q neuroblasts which is required for the anterior migration of QR neuroblasts (PubMed:23784779).
messages: axon
messages: dendrite

6239:CELE F26D2.13
gene id: 6239:CELE_F26D2.13
uniprot id: Q9XV59
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F49E7.1
gene id: 6239:CELE_F49E7.1
uniprot id: Q9GYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits.
messages: Belongs to the GAPVD1 family.
messages: Interacts with GDP-bound rab-5. Interacts with alpha-adaptin.
messages: Membrane
messages: clathrin-coated vesicle

6239:CELE C26D10.2
gene id: 6239:CELE_C26D10.2
uniprot id: Q18212
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DECD subfamily.
messages: Interacts with rsr-1/SRm160.
messages: Nucleus
messages: RNAi-mediated knockdown prevents germ cells from entering meiosis and results in the accumulation of unspliced mRNAs in the cytoplasm.
messages: Required for spliced RNA export out of the nucleus (PubMed:23149939). May play a role in spliceosome assembly.

6239:CELE M01E5.4
gene id: 6239:CELE_M01E5.4
uniprot id: O45690
names: Similarity
messages: Belongs to the UPF0561 family.

6239:CELE C08A9.1
gene id: 6239:CELE_C08A9.1
uniprot id: P41977
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: By heat.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Expressed in pharynx and rectum. Upon thermal stress, expressed in vulva, body wall muscles and hypodermis.
messages: Homotetramer.
messages: Mitochondrion

6239:CELE Y17G7B.12
gene id: 6239:CELE_Y17G7B.12
uniprot id: Q9XXI3
names: Similarity
messages: Belongs to the REXO4 family.

6239:CELE Y56A3A.19
gene id: 6239:CELE_Y56A3A.19
uniprot id: Q9U241
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

6239:CELE ZK20.5
gene id: 6239:CELE_ZK20.5
uniprot id: Q23449
names: Disruption Phenotype
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S14 family.
messages: RNAi-mediated knockdown results in sterility.

6239:CELE C35D10.1
gene id: 6239:CELE_C35D10.1
uniprot id: Q8WQG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC7 family.
messages: Membrane

6239:CELE F41D9.1
gene id: 6239:CELE_F41D9.1
uniprot id: Q94222
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

6239:CELE C49G7.3
gene id: 6239:CELE_C49G7.3
uniprot id: O16226
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F13D11.2
gene id: 6239:CELE_F13D11.2
uniprot id: Q27GU0
uniprot id: Q9XYD3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hunchback C2H2-type zinc-finger protein family.
messages: Expressed primarily in ectodermal cells during embryonic and larval development.
messages: Nucleus
messages: RNAi-mediated knockdown results in premature alae formation at the L3 larval stage (PubMed:21471153). This phenotype is partially suppressed in a sea-2 bp283 mutant background (PubMed:21471153).
messages: Required for the late stages of development (PubMed:9917360). Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production (PubMed:28933985, PubMed:21471153).

6239:CELE F01D4.2
gene id: 6239:CELE_F01D4.2
uniprot id: O17757
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F20D1.2
gene id: 6239:CELE_F20D1.2
uniprot id: Q93534
names: Subcellular Location Annotation
messages: trans-Golgi network

6239:CELE C01F1.6
gene id: 6239:CELE_C01F1.6
uniprot id: Q17555
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C23H5.2
gene id: 6239:CELE_C23H5.2
uniprot id: Q7YZV1
names: Similarity
messages: Belongs to the globin family.

6239:CELE Y48G1C.2
gene id: 6239:CELE_Y48G1C.2
uniprot id: G5ECJ6
names: Developmental Stage
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
messages: Expressed mainly in the pharynx in the loop stage embryo. At L1 larval stage, predominantly expressed in the pharynx with some expression in body wall muscle, anchor cells and tail region.
messages: Expressed predominantly in pharyngeal muscles in procorpus, metacorpus and terminal bulb (PubMed:12527374, PubMed:19210548). Expressed also in some neurons (ASE, ADF, AVA, AUA, RMDV and BAG) in the head region, anchor cell, vulva, cells around anus, body wall muscle and gondal distal tip cells (PubMed:12527374).
messages: Non-receptor tyrosine-protein kinase which plays a role in pharynx function by regulating pumping and the orientation of pharyngeal muscle fibers, independently of src-1 and src-2 (PubMed:19210548). May phosphorylate and thereby negatively regulate src-1 and src-2 activities (PubMed:12527374).

6239:CELE W05G11.3
gene id: 6239:CELE_W05G11.3
uniprot id: O44904
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE ZC239.13
gene id: 6239:CELE_ZC239.13
uniprot id: C8JQQ4
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE R10D12.2
gene id: 6239:CELE_R10D12.2
uniprot id: Q9XVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE R11E3.1
gene id: 6239:CELE_R11E3.1
uniprot id: Q9TYX4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE K07A12.2
gene id: 6239:CELE_K07A12.2
uniprot id: P90920
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Expression begins around the ventral closure stage of embryogenesis, continues throughout larval development and decreases in adulthood.
messages: In L1 larvae, expressed in a subset of epithelial cells including epidermal, vulval and rectal cells and the excretory duct and pore. Also detected in some neurons. Absent from internal epithelia such as the gut and pharyngeal tubes.
messages: Lethal at early L1 larval stage due to excretory defects. Maternal copy required for survival.
messages: Required for apical extracellular matrix organization and epithelial junction maintenance.

6239:CELE Y71G12B.14
gene id: 6239:CELE_Y71G12B.14
uniprot id: Q95XN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

6239:CELE E01A2.6
gene id: 6239:CELE_E01A2.6
uniprot id: Q966L3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: 16% embryonic lethality, reduced egg laying and a 0.9% increase in the number of male progeny (PubMed:23363597). Delayed progression of meiosis, which most likely results from defective disassembly of synaptonemal complex proteins, and defective chromosome structure, alignment and condensation (PubMed:23363597). RNAi-mediated knockdown results in reduced expression of the nlp-29 antimicrobial peptide following fungal infection by D.coniospora (PubMed:30036395). Worms show reduced body size and muscle function (PubMed:31767636). Worms lacking both akir-1 and ima-2 show reduced gonad size and aberrant diakinesis oocyte formation; defects are caused by impaired meiotic recombination (PubMed:30563860).
messages: Belongs to the akirin family.
messages: Expressed from the late embryo stage onwards, with high expression at the late L4 stage of larval development.
messages: Interacts with hda-1, a component of the NuRD complex (PubMed:30036395). Interacts with let-418, a component of the NuRD and MEC complexes (PubMed:30036395). Interacts with the transcription factor ceh-18 (PubMed:30036395). Interacts with ima-2 (PubMed:30563860).
messages: Localizes to somatic tissues throughout the body, including muscle cells (PubMed:31767636). Expressed in lateral epithelial seam cells, the hyp7 epidermal syncytium, and multiple head and tail neurons (PubMed:30036395).
messages: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in antifungal innate immunity, development of the muscle and sister chromatid cohesion (PubMed:23363597, PubMed:30036395, PubMed:30563860, PubMed:31767636). Plays a role in antifungal innate immunity by acting as a bridge between components of the NuRD (Nucleosome Remodeling and Deacetylase) and MEC chromatin remodeling complexes (PubMed:30036395). NuRD and MEC complexes bind to the promoters of antimicrobial peptide genes and may recruit other proteins such as ceh-18 to control gene expression in response to fungal infection (PubMed:30036395). During meiotic prophase I, plays a role in the disassembly of synaptonemal complex proteins and in the regulation of chromosome condensation and segregation (PubMed:23363597). Together with nuclear import receptor ima-2, required for the import and load of cohesin complex proteins in meiotic nuclei, possibly by acting as a bridge between ima-2 and cohesins (PubMed:30563860). Required for embryonic development of muscle tissue (PubMed:31767636).
messages: Nucleus

6239:CELE T05E7.3
gene id: 6239:CELE_T05E7.3
uniprot id: O01858
names: Similarity
messages: Belongs to the strumpellin family.

6239:CELE C25F6.4
gene id: 6239:CELE_C25F6.4
uniprot id: Q18163
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Expressed in neurons in head and tail, some motoneurons in ventral nerve cord, in PVP interneurons, pharynx and stomato-intestinal muscle.
messages: Expression begins during bean stage in hypodermal cells. At the 2-fold stage, also expressed in a few head and tail neurons.
messages: Perikaryon
messages: Receptor which, together with svh-4, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development (PubMed:23147028). May play a role in axon regeneration following injury in D-type motor neurons (PubMed:27984580).
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: Viable. No effect on axon regeneration 24 hours following injury of D-type motor neurons. Double knockout with svh-4 results in a more enhanced axon regeneration defect of D-type motor neurons as compared to the svh-4 single mutant.
messages: axon

6239:CELE C08B11.4
gene id: 6239:CELE_C08B11.4
uniprot id: Q09225
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the acyltransferase 3 family.
messages: In L1 larvae through to adult, hyp3 and hyp5, the most anterior cells in the hypodermis, and in intestine. Other hypodermal cells show weaker expression.
messages: Increased resistance to fluoxetine-induced nose muscle contraction. Slow development, embryonic lethality and defective yolk transport to the oocytes leading to accumulation of yolk granules in the pseudocoelomic fluid and appearance of pale eggs. Reduced level of sensitivity to dihomo-gamma-linolenic acid-induced sterility.
messages: Membrane
messages: Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development.

6239:CELE T07H8.5
gene id: 6239:CELE_T07H8.5
uniprot id: O61892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:KEF34 p08
gene id: 6239:KEF34_p08
uniprot id: P24889
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion inner membrane

6239:CELE C29E4.1
gene id: 6239:CELE_C29E4.1
uniprot id: P34340
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).

6239:CELE T02B11.5
gene id: 6239:CELE_T02B11.5
uniprot id: O16975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srj family.
messages: Membrane

6239:CELE R144.5
gene id: 6239:CELE_R144.5
uniprot id: Q09346
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCR8 family.
messages: Cytoplasm
messages: Part of a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy.

6239:CELE F53G12.10
gene id: 6239:CELE_F53G12.10
uniprot id: O01802
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).

6239:CELE ZK218.7
gene id: 6239:CELE_ZK218.7
uniprot id: O46001
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F10E7.9
gene id: 6239:CELE_F10E7.9
uniprot id: Q19301
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F49H12.1
gene id: 6239:CELE_F49H12.1
uniprot id: Q9N5S3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed ubiquitously (PubMed:16291785). Earliest expression is at the 50-cell stage, and persists throughout embryogenesis, larval stages and adulthood (PubMed:16291785).
messages: Involved in transcriptional regulation (By similarity). Required to specify left-right asymmetry of the ASE gustatory neurons, probably acting upstream of microRNA lsy-6 (PubMed:16291785, PubMed:26050091). Involved in maintaining the distinction between somatic and germ cells, perhaps acting by repressing germ cell-specific genes in somatic cells (PubMed:26050091).
messages: Nucleus speckle
messages: RNAi-mediated knockdown causes ectopic expression of gcy-5 in the ASEL gustatory neuron.

6239:CELE F41G3.4
gene id: 6239:CELE_F41G3.4
uniprot id: Q20291
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

6239:CELE K07C5.4
gene id: 6239:CELE_K07C5.4
uniprot id: Q21276
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for 60S ribosomal subunit synthesis.
messages: nucleolus

6239:CELE C06C6.4
gene id: 6239:CELE_C06C6.4
uniprot id: O62034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE Y32F6B.2
gene id: 6239:CELE_Y32F6B.2
uniprot id: G5EC02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

6239:CELE C29A12.4
gene id: 6239:CELE_C29A12.4
uniprot id: A7UQ09
uniprot id: I2HAJ6
uniprot id: I2HAJ7
uniprot id: Q18291
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y69A2AL.2
gene id: 6239:CELE_Y69A2AL.2
uniprot id: Q3V5J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

6239:CELE F19C7.2
gene id: 6239:CELE_F19C7.2
uniprot id: Q19589
names: Similarity
messages: Belongs to the peptidase S28 family.

6239:CELE F17A9.6
gene id: 6239:CELE_F17A9.6
uniprot id: O16218
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

6239:CELE ZK617.1
gene id: 6239:CELE_ZK617.1
uniprot id: A0A061ACT3
uniprot id: A0A061AE24
uniprot id: H2FLH2
uniprot id: H2FLH3
uniprot id: Q23551
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: A band
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Body muscles are unable to develop or sustain normal contractions but small regions within the myofilament lattice of individual muscle cells contract transiently in the absence of contraction of the adjacent lattice (PubMed:16765996, PubMed:7190524). This results in a nearly constant body twitching phenotype (PubMed:16765996, PubMed:7190524, PubMed:25851606). Resistant to nicotine-induced paralysis (PubMed:25851606).
messages: Determination of the mutation frequency of the unc-22 gene has been used to study the biological effects of short duration spaceflight.
messages: Expressed in body wall, anal, vulval, and pharyngeal muscles (at protein level).
messages: Forces generated by the contraction/relaxation cycles of muscle activity separate the regulatory domain from the catalytic core, activating the enzyme. At rest, the kinase domain is in a closed conformation. The active site is occupied by the autoinhibitory region (CDR), which makes extensive contact with the catalytic site, blocking substrate binding. At low forces the regulatory tail will unravel reversibly and expose the active site to its substrates, potentially stabilized by binding of Ca/CALM. At high forces the kinase begins to unfold and the integrity of the active site is disrupted.
messages: May interact (via protein kinase and CRD domains) with mak-1 (via protein kinase domain).
messages: Phosphorylated by mak-1 on the protein kinase domain and/or CDR domain in vitro.
messages: Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces (PubMed:18390597, PubMed:7190524). Plays a role in the organization of sarcomeres in body wall muscles (PubMed:25851606).
messages: sarcomere

6239:CELE W10G6.3
gene id: 6239:CELE_W10G6.3
uniprot id: O02365
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.
messages: First expressed in embryos that are starting to elongate, before hemidesmosomes-associated filaments are recruited to regions of the hypodermis adjacent to muscle. Expressed throughout larval stages and in adults.
messages: Forms some heteromeric filaments with ifb-1.
messages: Mainly expressed in regions of the hypodermis adjacent to muscle. Expressed in longitudinal stripes where the mechanosensory neurons interface with the hypodermis. Also expressed to the uterine seam and within the uterine-vulval cells.
messages: hemidesmosome

6239:CELE Y15E3A.1
gene id: 6239:CELE_Y15E3A.1
uniprot id: Q9U2R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F02C9.3
gene id: 6239:CELE_F02C9.3
uniprot id: P91203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

6239:CELE Y38A8.2
gene id: 6239:CELE_Y38A8.2
uniprot id: Q23237
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

6239:CELE B0213.14
gene id: 6239:CELE_B0213.14
uniprot id: O44658
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE D2023.4
gene id: 6239:CELE_D2023.4
uniprot id: O17731
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur (PubMed:15283700). Substrate specificity: thialysine > O-(2-aminoethyl)-L-serine > S-(2-aminoethyl)-D,L-homocysteine (PubMed:15283700). Does not act on polyamines, such as spermidine and spermine, nor on diamines putrescine and cadaverine (PubMed:15283700).
messages: Homodimer.

6239:CELE K07C5.8
gene id: 6239:CELE_K07C5.8
uniprot id: G5EE12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

6239:CELE R04D3.7
gene id: 6239:CELE_R04D3.7
uniprot id: Q21715
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE ZC434.2
gene id: 6239:CELE_ZC434.2
uniprot id: Q23312
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

6239:CELE B0393.5
gene id: 6239:CELE_B0393.5
uniprot id: Q17494
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y55F3AM.8
gene id: 6239:CELE_Y55F3AM.8
uniprot id: Q9N371
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE Y105E8B.3
gene id: 6239:CELE_Y105E8B.3
uniprot id: Q95Q34
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Expressed in pharynx (metacorpus and posterior bulbus). Expression is restricted to adult stage.
messages: RNAi-mediated knockdown causes early larval arrest. In adults, results in no obvious phenotype.
messages: Required for larval development.

6239:CELE K02F3.10
gene id: 6239:CELE_K02F3.10
uniprot id: Q21154
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Abnormal mitochondrial morphology with localized swellings and tubular extensions, and distended cristae. Double knockout with fzo-1 or eat-3 RNAi results in mitochondrial fragmentation. Double knockout with chch-3 results in reduced or no brood, poor growth and withered gonads which on a cellular level contain fewer mitochondria.
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Expressed in embryos.
messages: Mitochondrion outer membrane
messages: Sustains mitochondrial morphology probably through maintaining cristae morphology (PubMed:21248201). May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).

6239:CELE H17B01.4
gene id: 6239:CELE_H17B01.4
uniprot id: H2L0C0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE K08F11.4
gene id: 6239:CELE_K08F11.4
uniprot id: H2KZL6
uniprot id: Q8MPU1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE C53B4.1
gene id: 6239:CELE_C53B4.1
uniprot id: Q18795
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F41C3.2
gene id: 6239:CELE_F41C3.2
uniprot id: Q20265
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y71F9B.10
gene id: 6239:CELE_Y71F9B.10
uniprot id: Q9N4G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE B0336.1
gene id: 6239:CELE_B0336.1
uniprot id: Q10953
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Component of the beta-catenin-lit-1 complex which promotes phosphorylation, down-regulation and subcellular relocation of pop-1 (PubMed:10380924). Within the complex, activates lit-1-dependent kinase activity (PubMed:10380924). Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells (PubMed:17476329).
messages: Expressed in the developing cells of the embryo including hypodermal cells, neuroblasts, and mesodermal cells (PubMed:15572126). Expressed in seam cells in hermaphrodites at the L2 stage of larval development (PubMed:25569233).
messages: Interacts (independently of ARM repeat) with nhr-25 (PubMed:16890160). Component of the beta-catenin-lit-1 complex (also called the lit-1/wrm-1 complex or the wrm-1/lit-1 kinase complex) at least composed of lit-1 and wrm-1 (PubMed:10380924, PubMed:15066285). Interacts (via N-terminus) with lit-1; the interaction is direct and activates lit-1 kinase activity which leads to the phosphorylation of pop-1 (PubMed:10380924, PubMed:11560894, PubMed:15066285). This promotes pop-1 interaction with par-5 and translocation of pop-1 from the nucleus to the cytoplasm (PubMed:15066285).
messages: Nucleus
messages: Worms exhibit premature cell cleavage during embryogenesis, symmetrical cell division during gonadogenesis and undifferentiated intestines. Embryos show a defect in centrosome positioning that delays ABar spindle alignment and appear to lack endoderm.
messages: cell cortex

6239:CELE F58F12.1
gene id: 6239:CELE_F58F12.1
uniprot id: Q09544
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element (Probable).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE Y54H5A.4
gene id: 6239:CELE_Y54H5A.4
uniprot id: Q9N392
names: Disruption Phenotype
names: Function
names: Similarity
messages: Arrest at the L2-L3 stage in 90% oxygen.
messages: Belongs to the NARF family.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity).

6239:CELE C25H3.12
gene id: 6239:CELE_C25H3.12
uniprot id: Q9BIA4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (Probable). In particular, may act redundantly with the intraflagellar transport protein ift-139 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility.
messages: Belongs to the IFT43 family.
messages: Component of the IFT complex A (IFT-A) composed of at least che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
messages: Expressed in ciliated sensory neurons.
messages: No visible phenotype, with no defects in cilium morphology. Double knockout with intraflagellar transport protein ift-139 results in defective cilium morphology and function.
messages: cilium

6239:CELE T14E8.4
gene id: 6239:CELE_T14E8.4
uniprot id: Q5WRS0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Tissue Specificity
messages: (Microbial infection) Promotes infection by microsporidian pathogens such as N.parisii in the early larval stages of development (PubMed:34994689). Involved in ensuring the proper orientation and location of the spore proteins of N.parisii during intestinal cell invasion (PubMed:34994689).
messages: Expressed in the terminal bulb of the pharynx and the posterior of the intestine (at protein level) (PubMed:34994689). Expressed by intestinal cells and secreted into the intestinal lumen (at protein level) (PubMed:34994689).
messages: Expressed in the terminal bulb of the pharynx and the posterior of the intestine throughout development (at protein level) (PubMed:34994689). Expressed in the arcade cells of the pharynx in embryos and in L1 stage larvae (at protein level) (PubMed:34994689).
messages: Plays a role in promoting resistance to bacterial pathogens such as P.aeruginosa by inhibiting bacterial intestinal colonization.
messages: Resistant to infection by the microsporidian pathogen N.parisii and displays a fitness advantage phenotype, whereby there is increased fitness following infection by N.parisii (PubMed:34994689). Fewer invading N.parisii spores following infection at the L1 larval stage of development due to impaired orientation, location and angle of N.parisii spore proteins relative to the host's intestinal apical membrane (PubMed:34994689). Does not affect the ability of N.parisii to invade intestinal cells or N.parisii spore consumption by intestinal cells of L1 stage larvae (PubMed:34994689). Animals are not resistant to infection by N.parisii at the L3 larval stage of development (PubMed:34994689). Reduced survival following infection by the bacteria P.aeruginosa at the L1 and L4 larval stages due to increased accumulation of the bacteria within the intestinal lumen (PubMed:34994689). Reduced survival and increased numbers of N.parisii spore proteins following co-infection with N.parisii and P.aeruginosa (PubMed:34994689).
messages: Secreted
messages: Up-regulated following infection by the microsporidian pathogen N.parisii or the bacterial pathogen P.aeruginosa.

6239:CELE F46E10.10
gene id: 6239:CELE_F46E10.10
uniprot id: Q9UAV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible conversion of (S)-malate to oxaloacetate in the cytoplasm where oxaloacetate is used for gluconeogenesis.
messages: Cytoplasm
messages: Homodimer.

6239:CELE W06D12.2
gene id: 6239:CELE_W06D12.2
uniprot id: O45891
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE ZK757.4
gene id: 6239:CELE_ZK757.4
uniprot id: G5ECT4
uniprot id: G5EDL2
uniprot id: G5EG19
uniprot id: Q8I0G4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE T02G5.13
gene id: 6239:CELE_T02G5.13
uniprot id: Q22111
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
messages: May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). Likely to have a role in propionyl-CoA and adenosylcobalamin metabolism.
messages: Mitochondrion
messages: Reduced incorporation of 1-[14C]-propionate. Defective in adenosylcobalamin synthesis. incorporation into macromolecules.

6239:CELE W09C3.4
gene id: 6239:CELE_W09C3.4
uniprot id: P91529
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

6239:CELE T01G1.1
gene id: 6239:CELE_T01G1.1
uniprot id: G5EFJ0
uniprot id: G5EGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

6239:CELE C18A3.8
gene id: 6239:CELE_C18A3.8
uniprot id: Q09961
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in both symmetric and asymmetric neuronal lineages (PubMed:21698137). In the posterior embryo, expressed in PVQ/HSN/PHB neuroblasts and their descendants (PubMed:14627726, PubMed:21698137). Expressed in the sensory ASE neuron lineage (PubMed:21698137).
messages: Nucleus
messages: Probable transcription factor, involved in determining neuroblast cell fate, morphogenesis and aspects of terminal differentiation in both left/right symmetric and asymmetric neuronal lineages.
messages: RNAi-mediated knockdown disrupts differentiation of ASE L/R sensory neurons.

6239:CELE Y4C6B.3
gene id: 6239:CELE_Y4C6B.3
uniprot id: V6CLQ0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C25A8.4
gene id: 6239:CELE_C25A8.4
uniprot id: Q18143
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Putative chitinase.
messages: Secreted

6239:CELE R12H7.1
gene id: 6239:CELE_R12H7.1
uniprot id: A0A1C3NSM1
uniprot id: O01393
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Expressed in PLM neurons (at protein level). Expressed in the nerve ring (PubMed:33238150).
messages: Heterooligomer of unc-7 and unc-9. Interacts with F-actin (PubMed:33238150).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of gap junctions (PubMed:27015090, PubMed:33238150). Plays a role in maintaining gap junction activity to promote locomotion (PubMed:33238150).
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C46H11.4
gene id: 6239:CELE_C46H11.4
uniprot id: Q95Q62
names: Activity Regulation
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the inositol phosphokinase (IPK) family.
messages: Expressed in spermatheca.
messages: Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation (PubMed:9491893, PubMed:16186564). May also regulate ovulation downstream of actin cross-linker fln-1 (PubMed:23671426).
messages: Unlike mammalian IP3K, may not be regulated by calmodulin.

6239:CELE F14F8.11
gene id: 6239:CELE_F14F8.11
uniprot id: Q7YTN3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C06C6.5
gene id: 6239:CELE_C06C6.5
uniprot id: O62031
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y73B6BL.18
gene id: 6239:CELE_Y73B6BL.18
uniprot id: G5EDT8
names: Subcellular Location Annotation
messages: Cytoplasm

6239:CELE F17A2.6
gene id: 6239:CELE_F17A2.6
uniprot id: O17821
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE F22B8.6
gene id: 6239:CELE_F22B8.6
uniprot id: K8ESE2
uniprot id: O45391
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

6239:CELE W06D4.1
gene id: 6239:CELE_W06D4.1
uniprot id: Q9Y041
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the homogentisate dioxygenase family.
messages: Expressed in the hypodermis and intestine.
messages: Plays a role in the tyrosine degradation pathway.
messages: RNAi-mediated knockdown together with fah-1 RNAi rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant.

6239:CELE T07H6.5
gene id: 6239:CELE_T07H6.5
uniprot id: A0A1N7SYU8
uniprot id: A0A1N7SZ15
uniprot id: Q22328
names: Caution
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytic processing of the C-terminus is required for clustering activity but not for secretion nor traffic.
messages: Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions.
messages: Secreted
messages: Synapse

6239:CELE R08A2.2
gene id: 6239:CELE_R08A2.2
uniprot id: Q9U395
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE ZK593.8
gene id: 6239:CELE_ZK593.8
uniprot id: Q23544
names: Activity Regulation
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the fic family.
messages: Endoplasmic reticulum membrane
messages: Expressed at all developmental stages, with high expression during embryogenesis.
messages: Forms homodimers; homodimerization might be required for adenylyltransferase activity.
messages: Nucleus membrane
messages: Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (PubMed:27138431). In vivo target proteins include the heat-shock 70 family proteins hsp-1 and hsp-3 and the translation elongation factors eef-1A, eef-1G and eef-2 (PubMed:27138431). Can AMPylate core histone H3 in vitro (PubMed:27138431). Can also act as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from target proteins (By similarity). Decreases susceptibility to P.aeruginosa-mediated killing and might therefore play a role in the innate immune response (PubMed:27138431).
messages: The fido domain mediates the adenylyltransferase activity.
messages: The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. In response to endoplasmic reticulum stress, mediates de-AMPylase activity (By similarity). Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-274 binds ATP and competes with ATP-binding at Arg-415, thereby preventing adenylyltransferase activity (By similarity). In unstressed cells, disengagement of Glu-274 promotes adenylyltransferase activity (By similarity). Activation dissociates ATP-binding from Glu-274, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain (By similarity).
messages: Ubiquitously expressed, with high expression in the germline.

6239:CELE ZK328.7
gene id: 6239:CELE_ZK328.7
uniprot id: Q20255
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TTC21 family.
messages: Component of the IFT complex A (IFT-A) composed of at least che-11, daf-10, dyf-2, ift-139, ift-43 and ifta-1.
messages: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport (PubMed:27515926, PubMed:28479320). In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Functions in cilia biogenesis (PubMed:27515926).
messages: Expressed in ciliated sensory neurons in the head and tail.
messages: Shorter cilia with an irregular morphology resulting in functional defects characterized by defective movement, dauer formation, and mating behavior (PubMed:27515926). Double knockout with intraflagellar transport protein ift-43 results in defective cilium morphology and function (PubMed:28479320).
messages: cilium
messages: cilium basal body
messages: dendrite

6239:CELE 4R79.1
gene id: 6239:CELE_4R79.1
uniprot id: Q2HQL9
uniprot id: Q9U3S9
names: Caution
names: Cofactor
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 10 percent of animals are arrested at the larval stage. Defects in the grinder of the pharynx result in reduced pharyngeal pumping rates and a slower growth. In a nas-7 (hd116) mutant background, growth is further reduced.
messages: Binds 1 zinc ion per subunit.
messages: Expressed in pharyngeal and body wall muscles, intestine, hypodermis and pharyngeal mc2 cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Metalloprotease.
messages: Secreted

6239:CELE Y48A6B.1
gene id: 6239:CELE_Y48A6B.1
uniprot id: Q9XXD5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F41B5.7
gene id: 6239:CELE_F41B5.7
uniprot id: A0A0M7RF98
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C15B12.1
gene id: 6239:CELE_C15B12.1
uniprot id: Q18006
names: Cofactor
names: Similarity
messages: Belongs to the MSOX/MTOX family.
messages: Binds 1 FAD per subunit.

6239:CELE Y47D3A.10
gene id: 6239:CELE_Y47D3A.10
uniprot id: Q9NAH2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F11F1.7
gene id: 6239:CELE_F11F1.7
uniprot id: G5ED35
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nematode transthyretin-like family.
messages: Cell surface
messages: Expressed in the intestine cells.
messages: Homodimer. Interacts with ced-1. Interacts with nrf-5.
messages: Loses ability to bind apoptotic cells and results in reduced ability of cell corpse engulfment.
messages: Plays a role as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1. Important for the generation of extracellular phosphatidylserine vesicles that promote loss of the exoplasmic leaflet from apoptotic cells in a time-dependent manner. Required for the exposure of exoplasmic leaflet on the phagocytic cells surrounding the apoptotic cells. Does not affect the phosphatidylserine externalization in living cells. May play a role in mediating transfer of phosphatidylserine from phosphatidylserine vesicles to ced-1 bearing phagocytes or alternatively result in the activation of a phosphatidylserine transporter in the phagocyte that promotes phosphatidylserine externalization.
messages: Secreted

6239:CELE F26D10.3
gene id: 6239:CELE_F26D10.3
uniprot id: P09446
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: AMPylated by fic-1.
messages: Belongs to the heat shock protein 70 family.
messages: Induced by white light exposure.
messages: Interacts with E3 ubiquitin-protein ligase chn-1.

6239:CELE M01A8.1
gene id: 6239:CELE_M01A8.1
uniprot id: P34530
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K06H6.4
gene id: 6239:CELE_K06H6.4
uniprot id: O17105
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE K04G2.6
gene id: 6239:CELE_K04G2.6
uniprot id: Q21225
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Microsome membrane

6239:CELE Y113G7A.5
gene id: 6239:CELE_Y113G7A.5
uniprot id: G5EEC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y11D7A.11
gene id: 6239:CELE_Y11D7A.11
uniprot id: Q9XWR2
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y69H2.14
gene id: 6239:CELE_Y69H2.14
uniprot id: Q8I4C0
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE W02A11.4
gene id: 6239:CELE_W02A11.4
uniprot id: Q9NAN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer with aos-1.
messages: The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).

6239:CELE F25B5.5
gene id: 6239:CELE_F25B5.5
uniprot id: Q09316
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Potential regulator of CDK5 activity.

6239:CELE EEED8.8
gene id: 6239:CELE_EEED8.8
uniprot id: Q09297
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

6239:CELE T06D8.9
gene id: 6239:CELE_T06D8.9
uniprot id: Q22254
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE F54A3.3
gene id: 6239:CELE_F54A3.3
uniprot id: Q9N4J8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity). Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Plays a role in microtubule polymerization (PubMed:16054029).
messages: RNAi-mediated knockdown results in severely reduced microtubule growth rate.

6239:CELE C41G6.15
gene id: 6239:CELE_C41G6.15
uniprot id: Q9U3M3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T21H3.3
gene id: 6239:CELE_T21H3.3
uniprot id: A0A0K3AVX0
uniprot id: O16305
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calmodulin family.
messages: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
messages: Interacts (in the presence of Ca(2+)) with pde-1, madf-3, rpl-7A, tax-6, efk-1, npp-1, obr-4, sos-1, akt-1, unc-13, tag-196, ugt-48, nmy-2, F27D4.4, ddx-23, efa-6 and R11H6.4.
messages: May be involved in calcium-mediated signal transduction.
messages: This protein has four functional calcium-binding sites.

6239:CELE T07F8.2
gene id: 6239:CELE_T07F8.2
uniprot id: P91439
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE M142.1
gene id: 6239:CELE_M142.1
uniprot id: C0P283
uniprot id: G5EGP9
uniprot id: Q10658
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Tissue Specificity
messages: Adopts an immunoglobulin-like beta-sandwich fold forming a hydrophobic cavity that capture N-terminally myristoylated target peptides. Phe residues within the hydrophobic beta sandwich are required for myristate binding (By similarity).
messages: Belongs to the PDE6D/unc-119 family.
messages: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.
messages: Predominantly neuron-specific.
messages: Worms exhibit diverse nervous system defects including defects in feeding behavior and chemosensation. Phenotypes are due to defects in protein trafficking, such as mislocalization of odr-3 and gpa-13 proteins in olfactory neurons.

6239:CELE C43H6.6
gene id: 6239:CELE_C43H6.6
uniprot id: A8WFK8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R03E9.1
gene id: 6239:CELE_R03E9.1
uniprot id: G5EG44
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in intestinal cells in adults.
messages: Expressed weakly in larval stage L1 and strongly throughout the remainder of larval development (PubMed:9764821). Expressed in larval posterior intestinal cells and neurons (PubMed:9764821, PubMed:27402359).
messages: Heterodimer with mxl-1 in presence and absence of DNA.
messages: Nucleus
messages: RNAi-mediated knockdown increases lifespan, which is abolished on an mxl-2 or mml-1 mutant background, or by simultaneous RNAi-mediated knockdown of daf-16 or pha-4 (PubMed:24699255). RNAi-mediated knockdown causes delayed onset of polyglutamine-mediated paralysis (PubMed:24699255). RNAi-mediated knockdown reduces spore levels of the microsporidian pathogen N.parisii during infection, further reduced on an mxl-2 mutant background (PubMed:27402359).
messages: Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mxl-1 (PubMed:9764821). Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and may overlap with the insulin-like signaling pathway (PubMed:24699255, PubMed:27001890). Plays a role in autophagy (PubMed:27001890). Involved in promoting infection by the microsporidian pathogen N.parisii, possibly together with transcription factors pha-4 and zip-10 (PubMed:27402359).

6239:CELE T27C10.3
gene id: 6239:CELE_T27C10.3
uniprot id: Q9TZM2
names: Similarity
messages: Belongs to the Mo25 family.

6239:CELE D1025.2
gene id: 6239:CELE_D1025.2
uniprot id: O62122
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE Y37H2A.1
gene id: 6239:CELE_Y37H2A.1
uniprot id: F3Y5R9
uniprot id: Q9U2N7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

6239:CELE B0035.14
gene id: 6239:CELE_B0035.14
uniprot id: Q17438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661).
messages: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
messages: Endoplasmic reticulum membrane
messages: Expressed in many head neurons, vulva muscles and some tail neurons.

6239:CELE Y59A8B.22
gene id: 6239:CELE_Y59A8B.22
uniprot id: D9PTP5
uniprot id: D9PTP6
uniprot id: D9PTP7
names: Similarity
messages: Belongs to the sorting nexin family.

6239:CELE F59B10.3
gene id: 6239:CELE_F59B10.3
uniprot id: Q09951
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F49E10.5
gene id: 6239:CELE_F49E10.5
uniprot id: Q20595
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Adult life span extension and increased resistance to oxidative and heat stress but not to DNA damage, starvation or pathogen stress.
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism.
messages: Homodimer.
messages: In contrast to other members of the family, lacks the conserved Arg and Glu active sites at positions 417 and 446 respectively, suggesting that it lacks dehydrogenase activity.
messages: The THAP-type zinc finger mediates DNA-binding but is not required for repression of gene expression.

6239:CELE F42G9.2
gene id: 6239:CELE_F42G9.2
uniprot id: P52014
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE Y75B8A.9
gene id: 6239:CELE_Y75B8A.9
uniprot id: Q7K755
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE B0523.3
gene id: 6239:CELE_B0523.3
uniprot id: P34266
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic granule
messages: Expressed in all embryos during the early cleavage stages until the 100- and 200-cell stage, after which, expression diminishes. During larval development, first expressed in L1 larvae, but it is not highly expressed in the germline. Expression in the germline increases at later larval stages.
messages: Highly expressed in the germline.
messages: Interacts with pgl-1 and pgl-3; association with either pgl-1 or pgl-3 is not required for P-granule localization.
messages: Transient component of P-granule which is involved in germline development.
messages: Viable, and not temperature sensitive. Triple knockout with pgl-1 and pgl-3 results in 58% of progeny arresting as late embryos and 5% as larvae at 26 degrees Celsius.

6239:CELE F58B3.6
gene id: 6239:CELE_F58B3.6
uniprot id: Q20965
names: Similarity
messages: Belongs to the IFRD family.

6239:CELE F40F4.3
gene id: 6239:CELE_F40F4.3
uniprot id: Q20223
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: First detected in hypodermal precursor cells at the time of gastrulation. From the two-fold stage through to three-fold stages, expression is localized exclusively to hyp-7 but disappears in newly hatched L1s and subsequent developmental stages. Expression from L1 to adult stages is found in a single neuron in the ventral cord with a process into the nerve ring.
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
messages: May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell.
messages: Secreted

6239:CELE H15N14.1
gene id: 6239:CELE_H15N14.1
uniprot id: Q9U3D6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Can prevent somatic transgenes from inducing gene silencing via the RNA interference pathway. This may occur due to A-to-I editing of transgene-derived dsRNA, preventing transgene RNAi.
messages: Cytoplasm
messages: Expression begins early in embryogenesis where it is detected in late gastrula and comma stage embryos. By the comma stage, expression is highest in developing neuronal tissue in the head, tail and ventral side. Neuronal expression continues through embryogenesis and, by the L1 larval stage, is the prominent pattern. Expressed in most, if not all, cells of the nervous system at all larval stages and in adult animals. Also expressed in the developing vulva but not expressed in the adult vulva.
messages: Highest expression observed in the embryo. Levels decrease dramatically after embryogenesis, remain relatively constant during larval stages and increase again at the onset of adulthood.
messages: Interacts with double-stranded RNA-specific adenosine deaminase adr-2.
messages: Nucleus
messages: Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed:12426375). Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines (PubMed:24508457, PubMed:25373143). Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs (PubMed:24508457). Represses editing efficiency of the Y75B8A.8 3' UTR in neurons (PubMed:26917557). Required for correct expression and A-to-I editing of clec-41 (PubMed:28925356). Required for normal chemotaxis (PubMed:12426375, PubMed:14657490). Also required for normal vulva development (PubMed:12426375). Plays a role in determining lifespan (PubMed:20011587, PubMed:25373143). Not required for RNA interference (PubMed:12419225). Likely to play a role in determining whether a dsRNA enters the RNAi pathway (PubMed:14657490).

6239:CELE R01H2.6
gene id: 6239:CELE_R01H2.6
uniprot id: Q21633
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Expressed in neurons localized in the head and tail of adults.
messages: Interacts with E3 ubiquitin-protein ligase wwp-1 (PubMed:19553937). Interacts with RBR-type E3 ubiquitin transferase ari-1.1 (PubMed:16457801).
messages: RNAi-mediated knockdown very slightly reduces viability and brood size; phenotype is exacerbated on a mutant background which enhances the overall efficacy of RNAi (PubMed:12783801). Increases sensitivity to paraquat and reduces lifespan at 25 degrees Celsius, but not at 20 degrees Celsius (PubMed:19553937). Abolishes lifespan extension completely on an eat-2 mutant background (PubMed:19553937). Substantially increases embryonic expression of sup-35 (PubMed:19521497).
messages: Ubiquitin-conjugating enzyme E2 (PubMed:19553937). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19553937). Required for diet restriction-mediated lifespan extension, probably acting as part of a complex with ubiquitin-protein ligase wwp-1 (PubMed:19553937). Acts redundantly with lin-35/Rb in the regulation of pharyngeal morphogenesis during embryonic development by negatively regulating the expression of proteins such as sup-35 (PubMed:12783801, PubMed:19521497).

6239:CELE R07E4.6
gene id: 6239:CELE_R07E4.6
uniprot id: P30625
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons.
messages: Expressed at a low level during embryogenesis. Expression increases sharply approximately four hours before hatching with levels peaking during the first larval stage. Levels then decrease as development progresses to adulthood.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer that binds four cAMP molecules.
messages: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain but is not phosphorylated. The physiological significance of phosphorylations by other kinases is unclear.
messages: cytosol

6239:CELE C04C3.5
gene id: 6239:CELE_C04C3.5
uniprot id: Q6I6D4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the CLUAP1 family.
messages: Cilia of at least eight pairs of amphid neurons from mutant dyf(m185) animals are truncated at a middle segment, and empty amphidial sockets were seen indicating cilium structural abnormalities.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for sensory cilia biogenesis (PubMed:15713455).
messages: Expressed in a subset of sensory neurons including eight pairs of amphid neurons (ASE, ADF, ASG, ASH, ASI, ASJ, ASK and ADL), six inner labial neurons (IL2s) and two pairs of phasmid neurons (PHA and PHB).
messages: axon
messages: cilium
messages: dendrite

6239:CELE C56G2.7
gene id: 6239:CELE_C56G2.7
uniprot id: Q09289
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ADRM1 family.
messages: Component of the 19S proteasome regulatory particle complex (By similarity). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). Interacts with deubiquitinase ubh-4 (PubMed:23770237).
messages: Cytoplasm
messages: May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.
messages: Nucleus
messages: The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with rpn-2 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows ubh-4 access to the distal subunit.

6239:CELE T24C12.2
gene id: 6239:CELE_T24C12.2
uniprot id: Q22720
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras.

6239:CELE Y113G7A.4
gene id: 6239:CELE_Y113G7A.4
uniprot id: G5EF08
uniprot id: Q1RPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE C05E11.6
gene id: 6239:CELE_C05E11.6
uniprot id: Q17662
names: Similarity
messages: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.

6239:CELE ZK1307.6
gene id: 6239:CELE_ZK1307.6
uniprot id: Q09649
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

6239:CELE C28F5.2
gene id: 6239:CELE_C28F5.2
uniprot id: Q09240
names: Developmental Stage
names: Similarity
messages: Belongs to the globin family.
messages: Expression relative to adult is increased in the L3 stage and more so in dauers.

6239:CELE Y54E10BR.5
gene id: 6239:CELE_Y54E10BR.5
uniprot id: Q9N3D0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R11A8.2
gene id: 6239:CELE_R11A8.2
uniprot id: Q21924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOS2 family.
messages: Nucleus

6239:CELE F14H3.2
gene id: 6239:CELE_F14H3.2
uniprot id: O45363
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE K02C4.3
gene id: 6239:CELE_K02C4.3
uniprot id: Q09931
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE F59B8.2
gene id: 6239:CELE_F59B8.2
uniprot id: H9G2T4
uniprot id: Q21032
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

6239:CELE C28C12.10
gene id: 6239:CELE_C28C12.10
uniprot id: Q18284
uniprot id: X5LX76
uniprot id: X5M5R1
uniprot id: X5M8V6
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE F54D1.5
gene id: 6239:CELE_F54D1.5
uniprot id: Q20766
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C10H11.4
gene id: 6239:CELE_C10H11.4
uniprot id: P91038
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C38C3.5
gene id: 6239:CELE_C38C3.5
uniprot id: Q07749
names: Function
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.
messages: Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle.

6239:CELE C53A5.5
gene id: 6239:CELE_C53A5.5
uniprot id: D5MCU0
uniprot id: O17697
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C11E4.1
gene id: 6239:CELE_C11E4.1
uniprot id: Q93204
names: Similarity
messages: Belongs to the glutathione peroxidase family.

6239:CELE T21D12.15
gene id: 6239:CELE_T21D12.15
uniprot id: O16779
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C06A8.5
gene id: 6239:CELE_C06A8.5
uniprot id: Q17695
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with Zwilch homolog zwl-1, a component of the RZZ complex (PubMed:18765790). Interacts with mdf-1 and mdf-2 (PubMed:18936247).
messages: Recessive embryonic lethality (PubMed:18936247). Hemizygous mutants are viable and survive through embryogenesis, but are either lethal at the larval stage of development or sterile (PubMed:18936247). The oocytes of sterile mutants have extra chromosomes and prematurely exit the prophase stage of meiosis which results in endomitosis (PubMed:18936247). RNAi-mediated knockdown results in embryonic lethality (PubMed:18765790, PubMed:18936247). RNA-mediated knockdown results in defective cell division characterized by irregular chromosome alignment and segregation, longer spindles during chromatid separation, premature spindle pole separation, defective formation of kinetochore-microtubule attachments and chromatin bridge formation during the anaphase stage of mitosis (PubMed:18765790, PubMed:18936247, PubMed:24231804).
messages: Transient kinetochore component required for chromosome and spindle pole alignment and chromosome segregation during mitosis (PubMed:18765790, PubMed:18936247). Functions downstream of the RZZ complex to mediate kinetochore-microtubule attachments and nuclear envelope breakdown during cell division (PubMed:18765790, PubMed:18936247, PubMed:24231804). Required for kinetochore assembly and localizes the checkpoint proteins mdf-1 and mdf-2, dynein and dynactin to unattached kinetochores (PubMed:18765790, PubMed:18936247, PubMed:24231804). Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (PubMed:24231804). Required for embryonic development (PubMed:18765790, PubMed:18936247).
messages: cytoskeleton
messages: kinetochore
messages: spindle pole

6239:CELE C33H5.18
gene id: 6239:CELE_C33H5.18
uniprot id: P53439
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane
messages: Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns).
messages: Reduced levels of phosphatidylinositol. No effect on two-cell stage nuclear morphology. Significant rescue of the nuclear morphology defects resulting from inhibition of cnep-1 or partial inhibition of lpin-1 but does not rescue the nuclear envelope disassembly defects observed following depletion of npp-12.

6239:CELE ZK512.3
gene id: 6239:CELE_ZK512.3
uniprot id: P34641
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Plays a major role in programmed cell death.

6239:CELE K11D12.2
gene id: 6239:CELE_K11D12.2
uniprot id: O44625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

6239:CELE F10G7.3
gene id: 6239:CELE_F10G7.3
uniprot id: Q19326
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

6239:CELE C30F12.7
gene id: 6239:CELE_C30F12.7
uniprot id: Q95YD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Mitochondrion

6239:CELE T24B8.2
gene id: 6239:CELE_T24B8.2
uniprot id: Q22718
names: Similarity
messages: Belongs to the SNF7 family.

6239:CELE C48B6.5
gene id: 6239:CELE_C48B6.5
uniprot id: O01509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE ZC302.1
gene id: 6239:CELE_ZC302.1
uniprot id: Q23255
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Forms a complex with rad-50.
messages: Involved in DNA double-strand break repair (DSBR) (PubMed:11238374). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (PubMed:11238374). Also involved in meiotic DSB processing (PubMed:11238374). In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites (PubMed:16628214).
messages: Nucleus
messages: RNAi-mediated knockdown results in DNA damage repair defects following ionizing radiation with reduced ubiquitination at DNA damage sites.
messages: Required for meiotic crossing over and chiasma formation. Pachytene morphology and homolog pairing are normal. Vital in long term for maintenance of reproductive capacity of subsequent generations.

6239:CELE T01G6.8
gene id: 6239:CELE_T01G6.8
uniprot id: O16963
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE K10B3.6
gene id: 6239:CELE_K10B3.6
uniprot id: Q21407
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

6239:CELE Y37D8A.6
gene id: 6239:CELE_Y37D8A.6
uniprot id: Q9XWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE H14E04.1
gene id: 6239:CELE_H14E04.1
uniprot id: Q9TYP1
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of the A-ring sterols such as lathosterone (5alpha-cholest-7-en-3-one) thereby rendering them unsuitable as ligand precursors. May irreversibly shunt sterols away from hormone dafachronic acid production. Dafachronic acids act as ligands and bind directly to the nuclear hormone receptor (NHR) daf-12 suppressing dauer formation and inducing reproductive growth. By reducing the biosynthesis of dafachronic acids, this methyltransferase can regulate dauer larva formation.
messages: Expressed in the pharynx and hypodermal syncytium.
messages: Mutants show impaired dauer larvae production.

6239:CELE ZK809.3
gene id: 6239:CELE_ZK809.3
uniprot id: Q23597
names: Similarity
messages: Belongs to the complex I NDUFB6 subunit family.

6239:CELE F21E9.3
gene id: 6239:CELE_F21E9.3
uniprot id: O16586
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F30A10.5
gene id: 6239:CELE_F30A10.5
uniprot id: H2FLJ1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

6239:CELE T01G9.5
gene id: 6239:CELE_T01G9.5
uniprot id: P34808
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with mei-2.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner (PubMed:28783150). Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles (PubMed:8027178, PubMed:10809666, PubMed:12885567, PubMed:19087961, PubMed:23918937). In body wall muscles, regulates organization of myosin thick filaments (PubMed:22621901).
messages: Chromosome
messages: Cytoplasm
messages: Highly expressed in the female germline. Degradation at the meiosis-mitosis transition reduces cytoplasmic microtubule severing activity, thereby allowing the formation of larger mitotic spindles.
messages: Homohexamer; ATP hydrolysis initiates a cycle between an open spiral and a closed ring conformation which is probably involved in pulling tubulin dimers out from microtubules (PubMed:28783150). Interacts with mei-2, which may serve as a targeting subunit (PubMed:10809666). Interacts with mel-26, which targets mei-1 for ubiquitin mediated proteolysis (PubMed:13679921, PubMed:14528312, PubMed:23918937). Interacts with phosphatase pph-4.1 (PubMed:19087961).
messages: Phosphorylated (PubMed:16338136, PubMed:23918937). Phosphorylation by mbk-2 is required for its rapid degradation following meiosis II (PubMed:16338136). Likely dephosphorylated by the PP4 complex composed of catalytic subunit pph-4.1 and regulatory subunit ppfr-1 (PubMed:23918937).
messages: Polyubiquitination targets the protein for rapid degradation via the ubiquitin system at the end of meiosis. The BTB domain protein mel-26 may serve to specifically target mei-1 for ubiquitination by cul-3 containing complexes. The cul-3 protein is in turn regulated by neddylation by ned-8.
messages: RNAi-mediated knockdown at the L1 larval stage results in the disorganization of myosin thick filaments in adult body wall muscles characterized by the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A-bands. In addition, body wall muscle cells appear shorter and broader.
messages: spindle pole

6239:CELE F36D4.3
gene id: 6239:CELE_F36D4.3
uniprot id: G8JY81
uniprot id: Q95ZU1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE F15A4.4
gene id: 6239:CELE_F15A4.4
uniprot id: O17819
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE F56A6.1
gene id: 6239:CELE_F56A6.1
uniprot id: A0A0U1RML5
uniprot id: A0A0U1RML6
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE C09H6.3
gene id: 6239:CELE_C09H6.3
uniprot id: O17581
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC4/mau-2 family.
messages: Chromosomal, neuroanatomical, guidance and egg-laying defects. Altering the activity of both the dorsal repellent slt-1 and mau-2 leads to the abnormal dorsal projection of the AVM axon. Migrating cells and axons are mispositioned along both the antero-posterior and dorsoventral body axes.
messages: Cytoplasm
messages: May heterodimerize with scc-2/SCC2 to form the cohesin loading complex.
messages: Plays an important role in the loading of the cohesin complex on to DNA (By similarity). Forms a heterodimeric complex (also known as cohesin loading complex) with scc-2/SCC2 which mediates the loading of the cohesin complex onto chromatin (By similarity). Required for normal development until the fourth larval stage. Functions cell autonomously to guide migrations during the development of the nervous system. Participates in the guidance of mechanosensory neuron AVM by a slt-1-independent mechanism. Regulates chromosome segregation in early embryos.
messages: Ubiquitously expressed in embryos by late gastrulation. Becomes predominantly expressed in the nervous system as morphogenesis progresses.
messages: nucleoplasm

6239:CELE F10G7.8
gene id: 6239:CELE_F10G7.8
uniprot id: Q19324
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

6239:CELE K11B4.2
gene id: 6239:CELE_K11B4.2
uniprot id: O45685
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor.

6239:CELE C32F10.1
gene id: 6239:CELE_C32F10.1
uniprot id: O01686
names: Similarity
messages: Belongs to the OSBP family.

6239:CELE ZK370.5
gene id: 6239:CELE_ZK370.5
uniprot id: Q02332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
messages: Mitochondrion matrix

6239:CELE F44D12.9
gene id: 6239:CELE_F44D12.9
uniprot id: E1B6S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE H22K11.2
gene id: 6239:CELE_H22K11.2
uniprot id: O76632
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

6239:CELE C17C3.7
gene id: 6239:CELE_C17C3.7
uniprot id: Q18054
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed postembryonically at all larval and adult stages, including the developmentally arrested larval state known as dauer stage (PubMed:26438299). Expressed in neurons of the head and tail, including the motor neurons VD1, DA3, and DA7 (PubMed:26438299). Also expressed in the anal depressor muscle, anterior and posterior intestinal cells, and the head and body wall muscles (PubMed:26438299). Expressed in the PDE sensory neuron pairs and rare, transient expression seen in migrating distal tip cells of larval L3/L4 stages (PubMed:26438299).
messages: Hermaphrodites produce fewer live progeny at 20 degrees Celsius than wild-type, and also laying more unfertilized oocytes throughout the egg-laying period (PubMed:26438299). Abnormal gonad morphology (PubMed:26438299). Delayed recovery from the developmentally arrested larval state known as dauer (PubMed:26438299). Significantly longer lifespan (PubMed:26438299). Decreased movement (PubMed:26438299). RNAi-mediated knockdown causes an increase in daf-18 transcripts (PubMed:26438299).
messages: Nucleus
messages: Probable transcription factor (PubMed:26438299). Modulates lifespan and also recovery from the developmentally arrested larval state known as dauer, perhaps acting upstream of phosphatase PTEN/daf-18 (PubMed:26438299). Regulates expression of genes involved in cell division, cell-cycle regulation, and sexual reproduction, including daf-18 (PubMed:26438299).

6239:CELE F33D11.3
gene id: 6239:CELE_F33D11.3
uniprot id: O44774
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F39G3.8
gene id: 6239:CELE_F39G3.8
uniprot id: O16273
names: Similarity
messages: Belongs to the TGF-beta family.

6239:CELE C54C6.1
gene id: 6239:CELE_C54C6.1
uniprot id: P49622
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

6239:CELE T08D10.1
gene id: 6239:CELE_T08D10.1
uniprot id: G5EEG1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types (PubMed:17574230). In association with the components in the nfya-1-NF-Y complex, represses the expression of the T-box transcription factor tbx-2 throughout larval development, which most likely restricts its expression to certain tissues (PubMed:23933492). May act to repress txb-2 expression in conjunction with tbx-2 itself, which has an autoregulatory role (Probable). With the components in this complex, negatively regulates the expression of the homeobox protein egl-5 to spatially restrict its expression in tissues such as the head (PubMed:17574230). May regulate egl-5 expression in association with the mes-2-mes-3-mes-6 complex (PubMed:17574230).
messages: Expressed at all developmental stages (PubMed:15704008, PubMed:17574230). In larvae, highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail, while expression in most somatic cells is weak (PubMed:17574230). Not expressed in the gonads in larval stages (PubMed:15704008).
messages: Expressed in certain parts of the gonads with high expression in fertilized oocytes in the uterus and mature oocytes from the distal to the proximal arm of the gonad, but weak expression in the syncytial ovaries and immature oocytes at the beginning of the proximal arm of the gonad (PubMed:15704008). Highly expressed in the head ganglia neurons and the developing hermaphrodite vulva and male tail (PubMed:17574230). Weakly expressed in most somatic cells (PubMed:17574230). Not expressed in the intestine, the hypodermis, body wall muscle surrounding the pseudocoelomic space, secretory cells in the pharyngeal terminal bulb wall, in the small ganglia surrounding the pharynx and in the neurons running anteriorly to the sensory organs in the head (PubMed:15704008).
messages: Forms a heterotrimeric transcription factor complex (nfya-1-NF-Y complex) composed of nfya-1, nfyb-1 and nfyc-1, which binds to 5'-CCAAT-3' box motif in the promoters of its target genes (PubMed:17574230). Interacts with the nfyb-1 and nfyc-1 dimer; the interaction is required for subsequent binding to the 5'-CCAAT-3' box motif in DNA (PubMed:17574230). Does not interact with either nfyb-1 or nfyc-1 in their monomeric form (PubMed:17574230). Interacts with mes-3 (PubMed:17574230).
messages: Nucleus
messages: RNAi-mediated knockdown results in ectopic expression of the homeobox protein egl-5 in the head region of hermaphrodites (PubMed:17574230). RNAi-mediated knockdown results in morphological defects in the male tail due to cell transformation defects whereby anterior seam cells adopt a posterior seam cell fate, which is indicated by ectopic expression of the ray-specific protein pkd-2 in the anterior mid-body region (PubMed:17574230). This leads to impaired cell identities of the rays derived from seam cells (PubMed:17574230). These animals also have defective cell transformations in the ventral cord and generate two extra serotonergic CP neurons (PubMed:17574230). RNAi-mediated knockdown results in ectopic expression of tbx-2 in the gut and seam cells of L4 stage larvae and adults (PubMed:23933492).

6239:CELE F13B9.1
gene id: 6239:CELE_F13B9.1
uniprot id: H2KZQ8
uniprot id: H2KZQ9
uniprot id: Q95ZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Golgi apparatus membrane

6239:CELE Y54G9A.6
gene id: 6239:CELE_Y54G9A.6
uniprot id: Q9XWH0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BUB3 family.
messages: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments (PubMed:18248670, PubMed:19109417, PubMed:25987605). Promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Necessary for expression and kinetochore localization of bub-1 (PubMed:19109417, PubMed:25987605). Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis (PubMed:26483555).
messages: May interact with bub-1; for localization at the kinetochore and the onset of anaphase.
messages: Nucleus
messages: Viable, but with a reduced brood size (PubMed:25987605). Reduced bub-1 expression and localization at the kinetochore which may lead to the delay in the onset of anaphase during embryogenesis (PubMed:25987605). Defective synapsis with increased numbers of nuclei that contain asymmetrically aligned (clustered) chromosomes (PubMed:26483555). RNAi-mediated knockdown results in reduced survival as compared to wild-type animals in anoxic conditions (PubMed:18248670).
messages: kinetochore

6239:CELE M04G12.4
gene id: 6239:CELE_M04G12.4
uniprot id: A0A486WWJ9
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: DNA-binding protein which binds to the promoters of let-60, lin-14 and lin-28, possibly to regulate genes involved in hypodermal and vulval development (PubMed:21979920). Together with miRNAs mir-84 and let-7 may direct terminal differentiation of the seam cells, exit from the molting cycle, and vulva formation (PubMed:21979920). Does not regulate the expression of mir-84 (PubMed:21979920). May promote hypodermal differentiation in association with swsn-9, a component of SWI/SNF chromatin remodeling complexes (PubMed:21979920).
messages: Expressed from embryogenesis to adulthood (PubMed:21979920). First expressed in comma stage embryos (PubMed:21979920). Highly expressed in L4 larvae and adults (PubMed:21979920).
messages: Expressed in hypodermal seam cells, the somatic gonad and vulval precursor cells, body wall muscle and head neurons.
messages: May interact with swsn-9; the interaction promotes hypodermal differentiation.
messages: Nucleus

6239:CELE C14A4.1
gene id: 6239:CELE_C14A4.1
uniprot id: Q17949
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
messages: Embryonic lethal with the production of multinucleated cells from the one-cell stage of embryogenesis leading to the in utero accumulation of abnormal and enlarged embryos.

6239:CELE T04B2.2
gene id: 6239:CELE_T04B2.2
uniprot id: Q22146
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Expressed in early embryo and, during later stages of embryogenesis, in epithelial cells, body wall muscle, germline and mature sperm.
messages: Interacts with hmp-2.
messages: Non-receptor tyrosine-protein kinase which plays a role in morphogenesis by regulating the epidermal enclosure of the embryo, independently of its kinase activity (PubMed:15958510). Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation (PubMed:20805471).
messages: Nucleus
messages: RNAi-mediated knockdown causes a disruption in the dorsal intercalation and ventral migration of epidermal cells, preventing enclosure and elongation of the embryo. Epidermal cells tend to round up and appear to be defective in adhesion (PubMed:15958510). In addition, causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471).

6239:CELE F45F2.5
gene id: 6239:CELE_F45F2.5
uniprot id: G4SFC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE K08E5.2
gene id: 6239:CELE_K08E5.2
uniprot id: Q21339
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Plays a role in the regulation of life span.
messages: Membrane
messages: Nad-1 and nad-2 are coexpressed in the intestinal tract from early larvae to adults, expression is from the pharynx through to the anus. Expression level is significantly greater in the anterior half of the intestine than in the posterior half.
messages: Not detected in the embryo. Expressed at the early larval, late larval and adult stages, with highest levels at the late larval stage.

6239:CELE C18G1.4
gene id: 6239:CELE_C18G1.4
uniprot id: G5EBV6
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasmic granule
messages: Expressed throughout development from embryos to adults (PubMed:15238518, PubMed:27650246). Not expressed in somatic cells of embryos (PubMed:28806108). First expressed in 1-cell embryos, and expression continues until the 24-cell stage (PubMed:15238518). Highly expressed in early stage embryos (PubMed:19167332). Expression decreases after the 24-cell stage and is negligible throughout the rest of embryogenesis and early stages of larval development (PubMed:15238518, PubMed:19167332). During larval development, first expressed in the germline of L3 stage larvae (PubMed:15238518).
messages: Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate (PubMed:26787882). P-granule component involved in germline development (PubMed:15238518, PubMed:19372764, PubMed:24746798). Together with the P-granule component pgl-1, is involved in the formation of P-granules (PubMed:21402787, PubMed:24746798, PubMed:27594427). Together with pgl-1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules (PubMed:21402787, PubMed:27594427). In vitro, binds mRNA; this interaction is required for the formation of liquid-like droplets that resemble P-granules (PubMed:27594427). Most likely recruits pgl-1 into P-granules during autophagy (PubMed:19167332). Associates with adapters such as sepa-1 and is required for the accumulation and degradation of P-granules by autophagy in somatic cells (PubMed:19167332, PubMed:24140420, PubMed:28806108). This ensures exclusive localization of the P-granules in germ cells (PubMed:19167332, PubMed:28806108). In addition, may act redundantly with pgl-1 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms (PubMed:26598553). This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis (PubMed:26598553). May protect somatic cells from excessive apoptosis during normal development (PubMed:27650246).
messages: Highly expressed in the germline (PubMed:15238518). Expressed in most somatic cells (PubMed:27650246).
messages: May form a homodimer (PubMed:21402787, PubMed:26787882). Interacts with pgl-1 and pgl-2; this association is not required for P-granule localization of either pgl-1 or pgl-2 (PubMed:15238518). Interacts with sepa-1; the interaction is enhanced in the presence of RNA (PubMed:19167332, PubMed:24140420). Interacts with prmt-1; the interaction is direct (PubMed:24140420).
messages: Methylated at arginine residues in the RNA-binding RGG-box by prmt-1. Methylation promotes P-granule degradation by autophagy.
messages: The RNA-binding RGG-box is required for the recruitment of some P-granule components such as pos-1 and probably mRNA, but is dispensable for granule formation.
messages: The dimerization domain also acts as a hinge; changes in its structure probably impact oligomerization and RNA-binding.
messages: Viable, and not temperature sensitive (PubMed:15238518). Failed degradation and diffuse cytoplasmic localization of the P-granule component pgl-1 in the somatic cells of embryos (PubMed:19167332). Increased germ cell apoptosis in gonadal arms, and this is further increased following UV irradiation (PubMed:26598553). Double knockout with pgl-1 results in 37% of progeny arresting as late embryos and 9% as larvae at 26 degrees Celsius (PubMed:15238518). Double knockout with pgl-1 enhances the temperature-sensitive sterility phenotype and germline defects of the pgl-1 single knockout (PubMed:15238518, PubMed:26598553). Germline defects include increased apoptosis in the gonad, fewer germ nuclei, no sperm and no oocytes in the gonad arms (PubMed:15238518, PubMed:26598553). The gonads of the double knockout with pgl-1 degenerate as the adults age (PubMed:15238518). Conversely, double knockout with ced-1 results in reduced somatic cell apoptosis (PubMed:27650246). Triple knockout with pgl-1 and pgl-2 results in 58% of progeny arresting as late embryos and 5% as larvae at 26 degrees Celsius (PubMed:15238518). Triple knockout with pgl-1 and him-3 further reduces the number of self-cross progeny as compared to the pgl-1 and him-3 double mutant and him-3 single mutant (PubMed:15238518). Double RNAi-mediated knockdown with pgl-1 results in a reduced number of pos-1, mex-1 and glh-1 positive granules in embryos (PubMed:21402787). Quadruple RNAi-mediated knockdown with glh-1, glh-4 and pgl-1 results in offspring that display 27-89% sterility, abnormal oocytes and do not have embryos in the uterus (PubMed:24746798). These sterile offspring still produce sperm (PubMed:24746798). Furthermore, these offspring may have compromised P-granule integrity as there is diffuse cytoplasmic localization of the P-granule component deps-1, which may cause germ cells to initiate somatic reprogramming (PubMed:24746798). RNAi-mediated knockdown in a double ced-1 and hpl-2 mutant background rescues …

6239:CELE F10D2.2
gene id: 6239:CELE_F10D2.2
uniprot id: H2KZP8
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C41C4.4
gene id: 6239:CELE_C41C4.4
uniprot id: Q09499
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autophosphorylated mainly on serine residues.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Endoplasmic reticulum membrane
messages: In combination with RNAi-mediated knockdown of atf-6, causes sluggish movement, arrested development at the L2 larval stage, and lethality soon thereafter; larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). In combination with RNAi-mediated knockdown of pek-1, larvae have intestinal degeneration and develop many vacuoles in the intestinal cells (PubMed:16184190). RNAi-mediated knockdown restores fertility, reduces the accumulation of unspliced tra-2 in the cytoplasm and suppresses germ line masculinization caused by RNAi-mediated knockdown of rnp-4/RBM8A (PubMed:23149939).
messages: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:11779465). The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes (PubMed:11779465). Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis (PubMed:11779465, PubMed:16184190). Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 and many other genes, upon ER stress (PubMed:18216284, PubMed:16184190). By activating the UPR pathway during non-lethal hypoxia pre-conditioning, confers adaptive protection to subsequent exposure to hypoxia (PubMed:20733002). ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival (PubMed:11779465, PubMed:16184190). Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939).
messages: The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity).

6239:CELE F28F8.5
gene id: 6239:CELE_F28F8.5
uniprot id: H9G301
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Described as a member of the Mediator complex and a probable MED28 ortholog but shows very low similarity to known MED28 proteins and lacks the Pfam Med28 signature found in known MED28 proteins.
messages: Expressed from embryos to adults. Expressed in embryos from the two-fold stage, and is ubiquitously expressed during embryonic and larval stages of development.
messages: Interacts with mdt-6 and mdt-30.
messages: Nucleus
messages: Plays a role in normal growth and development.
messages: Ubiquitously expressed in tissues including epidermal, intestinal, pharyngeal and uterine, and is also expressed in vulval muscle cells and gut granules.
messages: Viable, but sterile with defective development that is prominent during the late larval stages of development. The developmental defects include a squat body stature referred to as a dumpy phenotype, irregular gut, defective gonadal growth, with incomplete gonad development in some animals, a protruding vulva phenotype, defective uterus and spermatheca formation, and excretory canal defects. RNAi-mediated knockdown results in 44% of animals arresting at either the embryonic or larval stage of development, and in a range of phenotypes including defective molting, protruding vulvae that burst, male tail ray defects and uncoordinated movement.

6239:CELE ZK1251.3
gene id: 6239:CELE_ZK1251.3
uniprot id: Q23431
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

6239:CELE T14E8.1
gene id: 6239:CELE_T14E8.1
uniprot id: H2KZU7
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed in body wall and vulva muscles, pharynx, intestine, excretory canals, distal tip cells and some neurons. Expressed in D-type motor neurons upon axon injury.
messages: Interacts (via cytoplasmic domain) with mlk-1 (PubMed:22388962). Interacts with shc-1 (via SH2 domain) (PubMed:27984580). May interact (when tyrosine-phosphorylated) with tns-1 (via SH2 domain) (PubMed:31109965).
messages: May be autophosphorylated on Tyr-890 following dimerization.
messages: Receptor tyrosine kinase which may phosphorylate mlk-1, a component of the mlk-1, mek-1 and kgb-1 pathway (PubMed:22388962). Involved in axon regeneration after injury by promoting the generation of productive and stable growth cones (PubMed:22388962, PubMed:27984580, PubMed:31109965).
messages: Viable. Reduced axon regeneration 24 hours following injury of D-type motor neurons.

6239:CELE C33G8.5
gene id: 6239:CELE_C33G8.5
uniprot id: Q18398
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C06E1.7
gene id: 6239:CELE_C06E1.7
uniprot id: P34302
names: Similarity
messages: Belongs to the glycosyltransferase 11 family.

6239:CELE F33D4.2
gene id: 6239:CELE_F33D4.2
uniprot id: Q9Y0A1
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the InsP3 receptor family.
messages: Disrupted defecation rhythm with reduced pharyngeal pumping in the presence of food resulting in constipation. Disrupted reversal/avoidance response to nose touch. Hermaphrodites display endomitotic oocytes following spermathecal dilation defect and defective ovulation. Loss of male fertility due to defects in turning behavior, spicule insertion and sperm transfer.
messages: Endoplasmic reticulum membrane
messages: Interacts with myo-1, myo-2, unc-54/myo-4 and nmy-2. Also interacts with iri-1.
messages: Isoform a is expressed in the anterior cells of the pharyngeal terminal bulb, vulva, rectal epithelial cells, spicule protractor muscles of the proctodeum and male-specific neuron CP8 or CP9. Isoform d is expressed in the spermatheca, excretory cell, amphid socket cells, PDA motor neuron, spicule retractor muscles, gubernaculum retractor muscles, posterior oblique muscles, diagonal muscles and the vas deferens. Also expressed in the intestine, pharynx, pharyngeal isthmus, pharyngeal intestinal valve, somatic gonad, hypodermal cells of the vulva, uterine sheath cells, tail, head, LUA motor neuron and the embryonic epidermis (at protein level).
messages: Produced by alternative promoter usage and alternative splicing.
messages: Produced by alternative promoter usage.
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis (PubMed:10499793, PubMed:10610772, PubMed:15194811, PubMed:16186564, PubMed:23671426). Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position (PubMed:10610772). Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity (PubMed:10610772). Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyngeal pumping (PubMed:10499793, PubMed:11553721, PubMed:12062062, PubMed:11950942, PubMed:15013747, PubMed:15133127, PubMed:16186564, PubMed:21191812). Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation, spermathecal valve dilation and male mating behavior (PubMed:9491893, PubMed:15194811, PubMed:16267094, PubMed:15958491). Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis (PubMed:11950942, PubMed:15498499, PubMed:18369461). Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses (PubMed:19730689). Involved in modulating lifespan, acting downstream of transcription factor atf-6 (PubMed:32905769).
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

6239:CELE M05D6.7
gene id: 6239:CELE_M05D6.7
uniprot id: Q21526
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

6239:CELE C43F9.6
gene id: 6239:CELE_C43F9.6
uniprot id: Q9XUG9
names: Similarity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.

6239:CELE F19H6.2
gene id: 6239:CELE_F19H6.2
uniprot id: Q19601
names: Similarity
messages: Belongs to the globin family.

6239:CELE B0252.3
gene id: 6239:CELE_B0252.3
uniprot id: Q10917
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

6239:CELE C47A10.6
gene id: 6239:CELE_C47A10.6
uniprot id: O45308
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y105C5B.15
gene id: 6239:CELE_Y105C5B.15
uniprot id: A0A078BQP7
uniprot id: Q9U309
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

6239:CELE F32B4.4
gene id: 6239:CELE_F32B4.4
uniprot id: O62203
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in most tissues including the hypodermal, muscle, neuronal, vulval and intestinal tissues (PubMed:30965033). Isoform a: Expressed in the pharynx, nerve ring, intestine, neurons and ventral nerve cord (PubMed:30965033).
messages: Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding (PubMed:8462849, PubMed:21750263, PubMed:30965033). Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine (PubMed:30965033). Has a role in the determination of life span (PubMed:30965033).
messages: Nucleus
messages: Viable, but have an extended lifespan (PubMed:30965033). There is a decrease in early progeny production, resulting in smaller self-fertile brood size, and an increase in late progeny production, which results in an extended self-fertile reproductive lifespan (PubMed:30965033). Defective pharyngeal grinder positioning, which results in feeding defects (PubMed:8462849). Animals also have protruding male spicules (PubMed:8462849).

6239:CELE C31E10.6
gene id: 6239:CELE_C31E10.6
uniprot id: Q93314
names: Similarity
messages: Belongs to the CCDC93 family.

6239:CELE K10G9.3
gene id: 6239:CELE_K10G9.3
uniprot id: G1K0W1
uniprot id: Q8WR51
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 68 family.
messages: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:15233996, PubMed:26854667). O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombospondin (TSP) and spondin families (By similarity).
messages: Endoplasmic reticulum
messages: Expressed in the anterior part of embryos, in the hypodermal and neuronal cells of the head. Expressed at different levels in a variety of cell types after hatching, including neuronal, hypodermal, muscle, intestinal, and somatic gonadal cells. Expressed in the nerve ring around the pharynx, in dorsal and ventral nerve cords, intestine, and a variety of hypodermal cells of L1-L3 larvae. Expressed in gonadal sheath cells, spermatheca, and tissues surrounding the vulva of adult hermaphrodites, and in the body wall muscle and hypodermal cells of adults of both sexes.
messages: Expressed starts at morphogenetic embryonic stages and continues throughout development.
messages: Golgi apparatus

6239:CELE K09C8.5
gene id: 6239:CELE_K09C8.5
uniprot id: G5EG78
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 Ca(2+) ion per heterodimer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.
messages: Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (By similarity). Required for embryonic morphogenesis playing a role in epidermal elongation at the twofold stage of embryonic development (PubMed:20876652). Required post-embryonically for basement membrane integrity and muscle-epidermal attachments, and specifically in the function of basement membrane components such as the type IV collagens (PubMed:20876652, PubMed:29440357). May have a role in inhibiting axon regeneration (PubMed:20876652). May functionally antagonize the peroxidasin pxn-1 (PubMed:20876652).
messages: Expressed in most differentiated epidermal cells throughout development from embryogenesis to adulthood (PubMed:20876652). In late gastrulation, expressed in epidermal precursors (PubMed:20876652).
messages: Expressed in vulval muscles and in some neurons including PVQ (PubMed:20876652). Expressed in the hypodermis and in coelomocytes (PubMed:25475546).
messages: RNAi-mediated knockdown causes no neuronal defects (PubMed:26194821). Furthermore RNAi-mediated knockdown rescues the neuronal defects of the pxn-1 mutant (ok785) (PubMed:26194821).
messages: Secreted
messages: basement membrane

6239:CELE F58A4.9
gene id: 6239:CELE_F58A4.9
uniprot id: P34476
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).
messages: Nucleus

6239:CELE C15A11.7
gene id: 6239:CELE_C15A11.7
uniprot id: Q93211
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C42C1.14
gene id: 6239:CELE_C42C1.14
uniprot id: A3QMC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

6239:CELE C47F8.2
gene id: 6239:CELE_C47F8.2
uniprot id: O62112
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T27E9.2
gene id: 6239:CELE_T27E9.2
uniprot id: O45864
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

6239:CELE R74.1
gene id: 6239:CELE_R74.1
uniprot id: Q09996
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Involved in protein synthesis (PubMed:23076791). Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
messages: RNAi-mediated knockdown results in an increase in the expression of gpdh-1 independent of hypertonic stress.

6239:CELE Y73F8A.16
gene id: 6239:CELE_Y73F8A.16
uniprot id: Q9NA56
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F54C1.5
gene id: 6239:CELE_F54C1.5
uniprot id: Q8I7G4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Component of the IFT complex B composed of at least che-2, che-13, dyf-1, dyf-3, dyf-6, dyf-11, dyf-13, ift-20, ift-74, ift-81, ifta-2, osm-1, osm-5 and osm-6.
messages: Expressed in most amphid, both phasmid and several labial-quadrant neurons.
messages: Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (PubMed:16049494). Specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors (PubMed:16049494). Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320). May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320). Required for polyglutamylation of axonemal tubulin in sensory cilia (PubMed:17761526).
messages: Sensory neurons are unable to take up a fluorescent dye from the media, a phenotype that is often associated with aberrant sensory cilia.
messages: cilium

6239:CELE K11D2.3
gene id: 6239:CELE_K11D2.3
uniprot id: D7SFR1
uniprot id: P35602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma- and beta'-type subunits), a medium adaptin (mu-type subunit AP47) and a small adaptin (sigma-type subunit AP19) (By similarity). Interacts (via N-terminus) with kvs-4 (PubMed:26762178).
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation (PubMed:8288128). Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9 (PubMed:26762178).
messages: Expressed in the cholinergic motor neuron DA9.
messages: Golgi apparatus
messages: clathrin-coated vesicle membrane
messages: dendrite

6239:CELE B0304.7
gene id: 6239:CELE_B0304.7
uniprot id: Q10936
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE ZC168.6
gene id: 6239:CELE_ZC168.6
uniprot id: Q23246
names: Tissue Specificity
messages: Expressed at higher level in testis.

6239:CELE T01H10.7
gene id: 6239:CELE_T01H10.7
uniprot id: Q22084
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE H34P18.1
gene id: 6239:CELE_H34P18.1
uniprot id: O76666
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F09G2.4
gene id: 6239:CELE_F09G2.4
uniprot id: O17403
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: CPSF is a heterotetramer composed of four distinct subunits 160, 100, 70 and 30 kDa.
messages: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.
messages: Nucleus

6239:CELE F36D4.5
gene id: 6239:CELE_F36D4.5
uniprot id: H2KZK4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the DeSI family.
messages: Cytoplasm
messages: Expressed in the pharynx, hypodermis, intestine, head neuron and tail neuron.
messages: Nucleus
messages: Protease which deconjugates SUMO from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubql-1 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234).
messages: Worms lacking both POST and ubql-1 have a shorter lifespan and display an accumulation of ubiquitinated proteins in the nucleus.

6239:CELE Y77E11A.2
gene id: 6239:CELE_Y77E11A.2
uniprot id: Q9N4A9
names: Similarity
messages: Belongs to the NAD kinase family.

6239:CELE K02B2.5
gene id: 6239:CELE_K02B2.5
uniprot id: P52821
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

6239:CELE B0212.4
gene id: 6239:CELE_B0212.4
uniprot id: H2KY64
uniprot id: Q5TKB1
uniprot id: Q95X47
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R13G10.4
gene id: 6239:CELE_R13G10.4
uniprot id: G5ED05
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: No visible phenotype. Quintuple knockout with cnnm-1, cnnm-2, cnnm-3 and cnnm-4 results in a reduced lifespan and 100% sterility.
messages: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-4 to regulate Mg(2+) homeostasis.

6239:CELE T12A2.2
gene id: 6239:CELE_T12A2.2
uniprot id: P46975
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STT3 family.
messages: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Despite low primary sequence conservation between eukaryotic catalytic subunits and bacterial and archaeal single subunit OSTs (ssOST), structural comparison revealed several common motifs at spatially equivalent positions, like the DXD motif 1 on the external loop 1 and the DXD motif 2 on the external loop 2 involved in binding of the metal ion cofactor and the carboxamide group of the acceptor asparagine, the conserved Glu residue of the TIXE/SVSE motif on the external loop 5 involved in catalysis, as well as the WWDYG and the DK/MI motifs in the globular domain that define the binding pocket for the +2 Ser/Thr of the acceptor sequon. In bacterial ssOSTs, an Arg residue was found to interact with a negatively charged side chain at the -2 position of the sequon. This Arg is conserved in bacterial enzymes and correlates with an extended sequon requirement (Asp-X-Asn-X-Ser/Thr) for bacterial N-glycosylation.
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal. Embryogenesis proceeds more slowly and embryos are osmo-sensitive.

6239:CELE Y47D3A.15
gene id: 6239:CELE_Y47D3A.15
uniprot id: Q9NAH7
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

6239:CELE Y92H12A.1
gene id: 6239:CELE_Y92H12A.1
uniprot id: G5EE56
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
messages: Cell membrane
messages: Expressed in some neurons (ASE, ADF, AVA, AUA, RMDV and BAG) in the head region, anchor cell, vulva, cells around anus, body wall muscle, pharyngeal muscles in procorpus and metacorpus (PubMed:12527374). Expressed in gonadal distal tip cells (PubMed:12527374, PubMed:16251208).
messages: Interacts (via SH2 domain and SH3 domain) with unc-5 (via cytoplasmic domain); the interaction requires kinase activity (PubMed:16024786). Interacts (when activated and phosphorylated at 'Tyr-416') with ina-1 (via cytoplasmic domain) and with ced-2 (via SH2 domain) (PubMed:20226672).
messages: May be activated by autophosphorylation (PubMed:19210548, PubMed:20226672). May be inhibited by csk-1-mediated phosphorylation (PubMed:12527374).
messages: May be phosphorylated on Tyr-528 by csk-1.
messages: Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine (PubMed:12110172, PubMed:12527374, PubMed:19210548). May be dispensable for pharyngeal muscle organization in the adult (PubMed:19210548). Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion (PubMed:16024786, PubMed:16251208). Plays a role in the migration of the QR neuroblast, a precursor of the AVM neuron, and in the migration of the axon cone of AVM, ALM, CAN and PVM neurons (PubMed:16251208, PubMed:22293500). May act downstream of migratory protein mig-13 to control AVM neuron migration (PubMed:22293500). Probably downstream of integrin ina-1/pat-3, plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).
messages: RNAi-mediated knockdown causes a growth arrest between gastrulation and the 2-fold stage and an increase in number of apoptotic cell corpses at the comma and 1.5-fold stages (PubMed:12527374, PubMed:16024786, PubMed:20226672). The few hermaphrodite animals reaching adulthood have gonadal defects characterized by the formation of a straight gonad resulting from defects in distal tip cells migration during the first and second turns (PubMed:16251208, PubMed:16024786).
messages: phagocytic cup

6239:CELE B0238.1
gene id: 6239:CELE_B0238.1
uniprot id: O16497
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE F15A2.4
gene id: 6239:CELE_F15A2.4
uniprot id: Q19474
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y17G9B.3
gene id: 6239:CELE_Y17G9B.3
uniprot id: Q9N574
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE B0024.15
gene id: 6239:CELE_B0024.15
uniprot id: Q8MQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE B0273.4
gene id: 6239:CELE_B0273.4
uniprot id: Q26261
names: Caution
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Expressed in cell bodies and axons of the VNC motor neurons that extend axons to the dorsal midline and within the ventral nerve cord (PubMed:12435363). Expressed in gonadal distal tip cells (DTC) (PubMed:16251208).
messages: Failed distal tip cell migration along the dorsal-ventral axis of the body. RNAi-mediated knockdown in mom-5, ced-10, ced-12 or mig-2 mutant backgrounds suppresses the migratory defect of distal tip cells in the respective single mutants.
messages: Glycosylated via C-mannosylation by dpy-19 at Trp-305 and Trp-308.
messages: In contrast to other members of the family, it lacks a canonical signal sequence; the existence of the signal sequence is therefore unsure.
messages: Interacts (via cytoplasmic domain) with src-1 (via SH2 domain and SH3 domain) (PubMed:16024786). Interacts with madd-4 (PubMed:25122090). Interacts with unc-129; the interaction is direct (PubMed:19169249).
messages: Membrane raft
messages: Phosphorylated on different cytoplasmic tyrosine residues (PubMed:11533026, PubMed:12435363, PubMed:16024786). May be phosphorylated on tyrosine residues by src-1 (PubMed:16024786). Tyrosine phosphorylation is unc-6-dependent (PubMed:11533026).
messages: Receptor for netrin (unc-6) required for axon guidance (PubMed:8332188, PubMed:11454756). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:1384987, PubMed:8332188, PubMed:11454756, PubMed:9473333). Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors (PubMed:11454756, PubMed:9473333). Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced-10/Rac, ced-12/ELMO and mig-2/RhoG (PubMed:10631179, PubMed:26292279, PubMed:17716643).
messages: neuron projection

6239:CELE R09B5.6
gene id: 6239:CELE_R09B5.6
uniprot id: O44608
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

6239:CELE R07E4.3
gene id: 6239:CELE_R07E4.3
uniprot id: Q21817
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE Y73B6BL.26
gene id: 6239:CELE_Y73B6BL.26
uniprot id: Q9GUF0
uniprot id: V6CJ96
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0286.5
gene id: 6239:CELE_B0286.5
uniprot id: Q10924
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in the somatic gonadal precursor cells, Z1 and Z4, of XO and XX L1 stage larvae (PubMed:14993191). Expression is sexually dimorphic later in larval L1 stage and appears to be gonad-specific (PubMed:14993191).
messages: Nucleus
messages: Probable transcription factor (PubMed:14993191, PubMed:20553900). Binds to the DNA sequence motif 5'-[TA]TGTT[TG]T[TG][ATG]TT-3' (PubMed:20553900). Regulates sexual dimorphism in the gonad, promoting male gonadal cell fates in chromosomally (XO) male animals, yet plays a role in gonadogenesis in both sexes; probably acts downstream of terminal regulator of sex determination tra-1, to control early gonadogenesis (PubMed:14993191). Positively modulates expression of homeobox protein egl-5, probably acting indirectly, during early gonadal development (PubMed:20553900).

6239:CELE C27C12.2
gene id: 6239:CELE_C27C12.2
uniprot id: Q18250
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Expressed in sheath cells and distal tip cells of the somatic gonad, as well as in the intestine and sperm (at protein level) (PubMed:20736289). Expression not observed in oocytes (at protein level) (PubMed:20736289).
messages: Nucleus
messages: RNAi-mediated knockdown causes abnormalities in oocyte development, including degrading oocytes in the proximal gonadal arm and ectopic developing oocytes in the distal arm (PubMed:20736289). RNAi-mediated knockdown targeted to the soma, on an rrf-1 mutant background, exhibits only a slight increase in the frequency of oocyte defects (PubMed:20736289).
messages: Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in oocyte development, acting cell-autonomously in the somatic gonad (PubMed:20736289). Involved in negative regulation of oocyte MAPK activation and inhibits oocyte maturation and ovulation (PubMed:20736289).
messages: perinuclear region

6239:CELE F35H8.3
gene id: 6239:CELE_F35H8.3
uniprot id: Q20082
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in vulval cells and all somatic gonad structures such as spermatheca, sheath cells, uterine cells and distal tip cells.
messages: No visible phenotype. Double knockout with lin-35 results in sterility, defects in gonad migration and vulval morphology.
messages: Nucleus
messages: Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.

6239:CELE F59F5.1
gene id: 6239:CELE_F59F5.1
uniprot id: G5ECR3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C32C4.5
gene id: 6239:CELE_C32C4.5
uniprot id: G5ECK3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in a limited number of non-sex-specific tissues in males, including 6-8 unidentified neurons of the head, ventral body wall muscle, and the PHCL/R neurons.
messages: In males, expressed in several sex-specific cell types during larval development and in the adult, including the A-type ray sensory neurons, ventral male-specific muscles, and unidentified neurons of the male posterior ventral nerve cord (PubMed:12231628). Transiently expressed during larval development in the hindgut (PubMed:12231628).
messages: Nucleus
messages: Probable transcription factor that plays a role in the development of the dopaminergic neurons of the male-specific genital sensilla (simple sense organs) known as rays, by negatively regulating the activity of the transcription factor ast-1 (PubMed:22069471, PubMed:12231628). Involved in male mating behavior, probably as a result of a role in the differentiation of male-specific diagonal muscles (PubMed:12231628, PubMed:22069471). Required for development of the male proctodeum (PubMed:12231628). May be dispensable in hermaphrodites (PubMed:12231628).
messages: RNAi-mediated knockdown causes defects in patterning of the dopaminergic neurons of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:12231628). Males are unable to sire progeny due to abnormal tail and gonad morphology, whereas hermaphrodites have no obvious phenotypic defects (PubMed:12231628).

6239:CELE Y38H6C.14
gene id: 6239:CELE_Y38H6C.14
uniprot id: Q9XX47
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FAM161 family.
messages: Expressed in amphid and phasmid ciliated neurons.
messages: cilium
messages: cilium axoneme

6239:CELE T16G1.10
gene id: 6239:CELE_T16G1.10
uniprot id: Q9XUP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

6239:CELE R06B9.2
gene id: 6239:CELE_R06B9.2
uniprot id: A0A131MBN2
uniprot id: A0A131MCQ1
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE T22C1.3
gene id: 6239:CELE_T22C1.3
uniprot id: Q22672
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE ZK218.1
gene id: 6239:CELE_ZK218.1
uniprot id: O45998
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE ZC239.12
gene id: 6239:CELE_ZC239.12
uniprot id: P91555
names: Similarity
messages: Belongs to the BACURD family.

6239:CELE Y69A2AR.7
gene id: 6239:CELE_Y69A2AR.7
uniprot id: H2L0S0
uniprot id: Q86DD3
uniprot id: Q95XH2
names: Similarity
messages: Belongs to the ATG101 family.

6239:CELE Y52B11A.9
gene id: 6239:CELE_Y52B11A.9
uniprot id: Q9XWF2
names: Similarity
messages: Belongs to the KIN17 family.

6239:CELE Y37D8A.14
gene id: 6239:CELE_Y37D8A.14
uniprot id: P55954
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

6239:CELE C17E7.6
gene id: 6239:CELE_C17E7.6
uniprot id: O16389
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F07C4.5
gene id: 6239:CELE_F07C4.5
uniprot id: P91209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE R57.1
gene id: 6239:CELE_R57.1
uniprot id: G8JYE4
uniprot id: P91406
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Membrane

6239:CELE Y57G11C.22
gene id: 6239:CELE_Y57G11C.22
uniprot id: O18246
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

6239:CELE F17E9.7
gene id: 6239:CELE_F17E9.7
uniprot id: O61520
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F53B7.3
gene id: 6239:CELE_F53B7.3
uniprot id: Q20716
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ISY1 family.
messages: Nucleus
messages: RNAi-mediated knockdown results in up-regulation of the transcription factor zip-10 and its downstream target asp-17.
messages: Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10 (PubMed:29664006). Does not affect the splicing of zip-10 (PubMed:29664006).
messages: Ubiquitously expressed.

6239:CELE Y54G2A.75
gene id: 6239:CELE_Y54G2A.75
uniprot id: L8E6I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

6239:CELE C12D8.8
gene id: 6239:CELE_C12D8.8
uniprot id: Q17939
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K04F1.4
gene id: 6239:CELE_K04F1.4
uniprot id: Q9TXK7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C41D11.8
gene id: 6239:CELE_C41D11.8
uniprot id: Q95NM6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA/RNA non-specific endonuclease family.
messages: Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.
messages: Homodimer.
messages: Mitochondrion
messages: The active site contains 1 hydrated magnesium ion that has only 1 direct interaction with the protein; all other interactions are via water molecules.

6239:CELE C04C11.2
gene id: 6239:CELE_C04C11.2
uniprot id: Q17624
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE T05C12.6
gene id: 6239:CELE_T05C12.6
uniprot id: Q22227
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSH family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasm
messages: Embryonic and larval cell fate, polarity, division and migration defects (PubMed:16899238, PubMed:17196955, PubMed:26795562). In several lineages of the developing gonad 42.6% of hermaphrodites do not have either one or both distal tip cells, which results in the absence of the corresponding gonad arm, and germline proliferation defects in the male germ line (PubMed:16899238). Defects in hypodermal morphogenesis including disorganized dorsal cell intercalation, eventually resulting in 2-fold stage arrest, and failed ventral enclosure in some worms (PubMed:16899238). Cell polarity and migration defects including mitotic spindle misalignment, particularly in the ABar blastomere which results in the posterior cells of the blastomere adopting an alternate more anterior position (PubMed:16899238). Defective QL neuroblast migration with 100% of descendants migrating towards the anterior rather than the posterior of larvae (PubMed:16899238). Disrupted asymmetric cell divisions of hypodermal seam cells with the mislocalization and reduced expression of a wnt/beta catenin pathway component sys-1 and its negative regulator apr-1, and wrm-1 in daughter seam cells (PubMed:26795562). Irregular symmetric localization of lin-17/Frizzled in ectodermal blast B cells (PubMed:17196955).
messages: Expressed throughout embryonic and larval development (PubMed:16899238). Expressed in most embryonic cells during hypodermal morphogenesis, and in Z1 and Z4 distal tip precursor cells, in distal tips cells during gonadal migration and in the gonandal primordium, which become vulval precursor cells, during larval development (PubMed:16899238). Also expressed in hypodermal precursor cells P11 and P12 and their daughter cells P11.a, P11.p, P12.a and P12.p, and in the SDQL and PVM neurons which are derived from the QL neuroblast (PubMed:16899238). During larval development, expressed in blast B cells and its descendants, the QL cell and in cells in the nerve ring (PubMed:16631156).
messages: Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:26795562). Functions redundantly with other dishevelled family members throughout development (PubMed:19298786, PubMed:25344071, PubMed:26460008, PubMed:26795562). During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells (PubMed:16899238, PubMed:26795562). In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the correct mitotic spindle orientation of the ABar blastomere division plane (PubMed:16899238, PubMed:25344071). Controls the polarity and the asymmetric localization of downstream components of the wnt/beta-catenin asymmetry pathway, and in particular, controls the asymmetric localization of the wnt receptor lin-17/Frizzled in ectodermal blast B cells (PubMed:16631156, PubMed:17196955, PubMed:19298786, PubMed:26795562). May act redundantly with dsh-2 to regulate the expression and nuclear localization of the beta-catenin homolog wrm-2, but alone seems to be required for the polarity of wrm-2 during the asymmetric cell division of hypodermal seam cells (PubMed:26795562). Also, maintains the polarity and migration of QL neuroblasts in larvae (PubMed:16899238). During the embryonic development of touch receptor neurons, may act redundantly with dsh-1, downstream of wnt signaling ligands and the wnt receptor lin-17/Frizzled, to direct the growth of neurites of touch receptor neurons towards the anterior of the body of the worm and towards the PLM touch receptor neuron and other tail neurons (PubMed:26460008). May play a role in the guidance of posterior D-type motor neuron axons along the anteroposterior axis (PubMed:19259273).
messages: The DEP domain is required for cell membrane localization.
messages: cell cortex

6239:CELE M03F4.2
gene id: 6239:CELE_M03F4.2
uniprot id: P10986
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: In this organism there are four genes coding for actin. The sequences coded by genes 1 and 3 are identical. There are a few variations in the actins coded by genes 2 and 4.
messages: cytoskeleton

6239:CELE K07E3.8
gene id: 6239:CELE_K07E3.8
uniprot id: Q7YZW5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Axon guidance defects of nerve ring-associated interneurons that extend their axons posteriorly into the right ventral nerve cord as well as defects in the axon guidance of D-type motor neurons that project their axons longitudinally along the ventral nerve cord. No axon guidance defects are observed for the AVG midline neuron.
messages: Belongs to the cytochrome b5 family. MAPR subfamily.
messages: During the 1.5 fold embryo stage, detected in the AVG pioneer neuron and in the developing ventral nerve cord. At larval stage L1, detected in the AVG, CEPDL/R, RMDVL/R, RIVL/R, AVAL/R, RMDL/R, and RMDDL/R neurons. At larval stage L4, expression continues in the AVG neuron and a subset of nerve ring neurons that extend axons into the right ventral nerve cord.
messages: Expressed in the AVG pioneer midline neuron and in several nerve ring neurons that extend projecting axons into the right ventral nerve cord.
messages: Interacts with unc-40 (via cytoplasmic domain).
messages: Membrane
messages: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 84 and 106.
messages: Transmembrane protein required for the axon guidance of a subset of ventral nerve cord-associated interneurons and motor neurons. May function with the netrin receptor unc-40 in axon guidance.
messages: axon

6239:CELE T27A3.2
gene id: 6239:CELE_T27A3.2
uniprot id: P91502
names: Similarity
messages: Belongs to the peptidase C19 family.

6239:CELE Y38C9A.2
gene id: 6239:CELE_Y38C9A.2
uniprot id: Q18905
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.

6239:CELE F26E4.11
gene id: 6239:CELE_F26E4.11
uniprot id: P90859
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Proposed to have a role in neuroprotection.

6239:CELE Y73F8A.11
gene id: 6239:CELE_Y73F8A.11
uniprot id: Q9NA59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Membrane

6239:CELE C54C8.11
gene id: 6239:CELE_C54C8.11
uniprot id: G5EEZ8
uniprot id: L8E6J1
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F21F3.1
gene id: 6239:CELE_F21F3.1
uniprot id: P91268
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: Probable lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).
messages: Secreted

6239:CELE Y48E1A.1
gene id: 6239:CELE_Y48E1A.1
uniprot id: G5ED21
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

6239:CELE C05C8.1
gene id: 6239:CELE_C05C8.1
uniprot id: A6PVA5
uniprot id: O16314
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion

6239:CELE C06B3.5
gene id: 6239:CELE_C06B3.5
uniprot id: Q17704
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

6239:CELE C10E2.6
gene id: 6239:CELE_C10E2.6
uniprot id: O17328
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F36H1.4
gene id: 6239:CELE_F36H1.4
uniprot id: A0A061AD43
uniprot id: A0A061AEC4
uniprot id: Q03345
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Essential for vulval induction; acts independently of rom-1.
messages: Essential for vulval induction; its activity on vulval precursor cells is partially dependent on rom-1.
messages: Expressed at all larval stages.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes (PubMed:1641037, PubMed:15455032, PubMed:16678779, PubMed:17891142). Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation (PubMed:15194811, PubMed:9491893). Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by activating receptor lin-23-mediated signaling cascade (PubMed:17891142).
messages: RNAi-mediated knockdown in combination with double mutants for the class A and B synMuv genes lin-36;lin-15A, lin-8;lin-15B, lin-15AB, lin-35;lin-8, lin-8;lin-36, lin-8;lin-9, lin-8;lin-37 or dpl-1;lin-15A results in suppression of the synthetic multivulva phenotype.

6239:CELE C36E6.3
gene id: 6239:CELE_C36E6.3
uniprot id: P19625
names: Miscellaneous
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: This chain binds calcium.

6239:CELE F57G9.2
gene id: 6239:CELE_F57G9.2
uniprot id: O62267
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y37D8A.17
gene id: 6239:CELE_Y37D8A.17
uniprot id: A0A1N7SYQ5
uniprot id: A0A1N7SYR4
uniprot id: A0A1N7SYS5
uniprot id: Q9XWV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

6239:CELE F07C4.4
gene id: 6239:CELE_F07C4.4
uniprot id: P91210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y17D7B.1
gene id: 6239:CELE_Y17D7B.1
uniprot id: O45910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F28C6.2
gene id: 6239:CELE_F28C6.2
uniprot id: Q19862
names: Similarity
messages: Belongs to the AP-2 family.

6239:CELE Y54G11A.2
gene id: 6239:CELE_Y54G11A.2
uniprot id: Q9XW03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

6239:CELE W06F12.3
gene id: 6239:CELE_W06F12.3
uniprot id: O45897
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE F32B5.1
gene id: 6239:CELE_F32B5.1
uniprot id: O01854
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

6239:CELE C30B5.3
gene id: 6239:CELE_C30B5.3
uniprot id: Q18317
names: Function
names: Tissue Specificity
messages: Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis.
messages: Expressed specifically in the spermatogenic germ line.

6239:CELE F44F4.7
gene id: 6239:CELE_F44F4.7
uniprot id: Q20410
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the nematode receptor-like protein sra family.
messages: Expressed in neurons RIF/RIG and PVT.
messages: Membrane

6239:CELE F53H8.2
gene id: 6239:CELE_F53H8.2
uniprot id: P51485
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR) (PubMed:15878875). May play a role in clathrin-mediated GPCR endocytosis (PubMed:15878875). Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition (PubMed:20207731). Involved in egg-laying (PubMed:15878875).
messages: Belongs to the arrestin family.
messages: Component of a complex composed of arr-1, daf-18 and mpz-1 (PubMed:20207731). Within the complex, interacts (via C-terminus) with mpz-1 (via PDZ domain) and phosphatase daf-18 (PubMed:20207731). May interact (via C-terminus) with clathrin chc-1 and beta-2 adaptin (AP2) apb-1 (PubMed:15878875).
messages: Expressed in head neurons, nerve ring and ventral nerve cord (at protein level) (PubMed:15878875). Expressed in the nervous system including the nerve ring and the ventral and dorsal nerve cords (PubMed:15878875, PubMed:15157420). Highly expressed in amphid chemosensory neurons AWA, AWB, AWC, ADL and ASH, and in hermaphrodite specific neuron HSN (PubMed:15878875, PubMed:15157420). Also expressed in the intestine (PubMed:15157420).
messages: No effect on the response to the aversive chemical stimulus octanol or to volatile attractants (PubMed:15157420). Behavioral adaptation to prolonged exposure to isoamyl alcohol or benzaldehyde is impaired (PubMed:15878875). Recovery of chemotaxis from odorant-induced adaptation is impaired (PubMed:15878875). Moderate reduction in chemotaxis towards volatile attractant diacetyl but not towards isoamyl alcohol and benzaldehyde (PubMed:15878875). Slight defect in egg-laying (PubMed:15878875). Increased lifespan and nuclear localization of daf-16 (PubMed:20207731). Reduced lifespan in a daf-16 (mu86) mutant background or in a mpz-1 RNAi-mediated knockdown background (PubMed:20207731).
messages: Perikaryon
messages: The C-terminus (aa 369-435) is required for the recovery of chemotaxis from odorant-induced adaptation but is dispensable for behavioral adaptation to chemoattractant isoamyl alcohol.
messages: The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates the interaction with the AP-2 complex subunit apb-1.
messages: dendrite

6239:CELE R05F9.10
gene id: 6239:CELE_R05F9.10
uniprot id: Q21746
names: Similarity
messages: Belongs to the SGT family.

6239:CELE ZK1290.5
gene id: 6239:CELE_ZK1290.5
uniprot id: Q09632
names: Similarity
messages: Belongs to the aldo/keto reductase family.

6239:CELE T13B5.9
gene id: 6239:CELE_T13B5.9
uniprot id: Q965L2
names: Similarity
messages: Belongs to the peptidase M8 family.

6239:CELE H20J04.5
gene id: 6239:CELE_H20J04.5
uniprot id: Q9N5M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE AH6.10
gene id: 6239:CELE_AH6.10
uniprot id: Q09208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F31E3.3
gene id: 6239:CELE_F31E3.3
uniprot id: P53016
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Heteropentamer of various rfc subunits that forms a complex (RFC) with PCNA in the presence of ATP.
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).

6239:CELE Y58A7A.6
gene id: 6239:CELE_Y58A7A.6
uniprot id: Q966A3
names: Similarity
messages: Belongs to the globin family.

6239:CELE Y39E4B.9
gene id: 6239:CELE_Y39E4B.9
uniprot id: C3JXF0
uniprot id: D0Z5N7
uniprot id: Q6QMT2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Transfers N-acetylgalactosamine onto carbohydrate substrates (By similarity). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5 (PubMed:12944392). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796).
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein.

6239:CELE T19B10.11
gene id: 6239:CELE_T19B10.11
uniprot id: G5EEH5
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAX family.
messages: Expressed weakly in L1 animals and strongly throughout the remainder of larval development (PubMed:9764821). Expressed in posterior intestinal cells, neurons, hypodermal cells and body wall muscles (PubMed:9764821).
messages: Heterodimer with mdl-1 in presence and absence of DNA.
messages: Nucleus
messages: RNAi-mediated knockdown increases lifespan, which is abolished on an mxl-2 or mml-1 mutant background, or by simultaneous RNAi-mediated knockdown of daf-16 or pha-4 (PubMed:24699255). RNAi-mediated knockdown causes delayed onset of polyglutamine-mediated paralysis (PubMed:24699255).
messages: Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mdl-1 (PubMed:9764821). Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging and may overlap with the insulin-like signaling pathway (PubMed:24699255). Involved in promoting infection by the microsporidian pathogen N.parisii (PubMed:27402359).

6239:CELE DY3.7
gene id: 6239:CELE_DY3.7
uniprot id: G5EFD9
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Basolateral cell membrane
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed in embryos, larvae and in adults. Expressed in the developing vulva at the L4 larval stage and in the hypodermis at the L3 larval stage.
messages: Expressed in the germline.
messages: May interact with tetraspanin tsp-12; the interaction promotes sup-17 cell membrane localization.
messages: Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification (PubMed:9428412, PubMed:9409830, PubMed:16197940). By modulating glp-1/Notch signaling, plays a role in germline development (PubMed:16197940). Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development (PubMed:28068334). Probably by shedding ephrin efn-4, regulates axon guidance of SDQL neuron during development (PubMed:26903502).
messages: RNAi-mediated knockdown in a glp-1 (ar202) constitutively active mutant background restores fertility.

6239:CELE Y47D3A.28
gene id: 6239:CELE_Y47D3A.28
uniprot id: Q9U2C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

6239:CELE T27E9.9
gene id: 6239:CELE_T27E9.9
uniprot id: Q9U358
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Does not form a functional homopentameric ion channel. Forms a functional heteropentameric ion channel composed of acc-1 and acc-4. May interact with acc-2; the interaction does not result in significant heteropentameric ion channel activity.
messages: Expressed in all cholinergic motor neurons except for ASJ and RIB neurons. Also expressed in AVF neurons.
messages: Grossly normal movement. In addition, in response to induced acetylcholine release, there is prolonged and slow decay of excitory postsynaptic currents which results in increased release of synaptic vesicles during that late phase of synaptic vesicle release in cholinergic motor neurons. Knockout in an lgc-46 gain of function mutant background suppresses the slow locomotion defect in the single lgc-46 gain of function mutant. Knockout together with gain of function mutations in lgc-46 and acr-2 suppresses the convulsion defects in the double lgc-46 and acr-2 double gain of function mutant.
messages: Presynaptic cell membrane
messages: Probable acetylcholine-gated chloride channel subunit (PubMed:15579462). Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1 (PubMed:15579462). May function with lgc-46 to regulate synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons (PubMed:27782882).
messages: axon

6239:CELE R02F2.2
gene id: 6239:CELE_R02F2.2
uniprot id: Q21653
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed in muscles in the body wall and head, and in the nervous system in neurons including FLP and ASE neurons in the head.
messages: Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress.
messages: Viable with normal development, size and lifespan. Reduced sensitivity to factors that induce neurodegeneration. Improved chemosensory response in aging worms.

6239:CELE F57C7.2
gene id: 6239:CELE_F57C7.2
uniprot id: G5ED88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

6239:CELE T11F9.5
gene id: 6239:CELE_T11F9.5
uniprot id: Q22401
names: Caution
names: Function
names: Subcellular Location Annotation
messages: May lack metalloprotease activity.
messages: Secreted
messages: Ser-137 is present instead of the conserved His which is expected to be zinc-binding residue. There is therefore some uncertainty concerning the enzymatic activity of this protein.

6239:CELE C18E9.11
gene id: 6239:CELE_C18E9.11
uniprot id: Q95NU5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen
messages: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
messages: Worms show defects in asymmetric divisions in early embryos. In particular, mutations specifically affect the reestablishment of asymmetric PAR protein domains in the P1 cell at the 2-cell stage.

6239:CELE T22B11.2
gene id: 6239:CELE_T22B11.2
uniprot id: O44563
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C07H6.6
gene id: 6239:CELE_C07H6.6
uniprot id: Q95YE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEL2 family.
messages: DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability (PubMed:10882129, PubMed:16951081). Regulator of telomere length (PubMed:11696330, PubMed:11641227).
messages: Nucleus
messages: telomere

6239:CELE T08B2.9
gene id: 6239:CELE_T08B2.9
uniprot id: Q9GYS8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

6239:CELE K10C3.6
gene id: 6239:CELE_K10C3.6
uniprot id: O45666
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Homodimer (PubMed:22511885). Interacts with nuclear hormone receptors nhr-80 and nhr-66; the interactions are direct (PubMed:22511885). May interact with nuclear hormone receptors nhr-13, nhr-22, nhr-79, nhr-105, and nhr-256 (PubMed:22511885).
messages: Nucleus
messages: Orphan nuclear receptor (PubMed:25981666). Regulates expression of genes involved in fat metabolism and in maintaining homeostasis of fatty acid saturation, such as lipid desaturase fat-7, and acyl-CoA synthetase acs-2 (PubMed:25981666, PubMed:15719061, PubMed:22511885). May form part of a negative feedback loop with fat-7 to limit mitochondrial beta-oxidation, in which it stimulates expression of fat-7 and acs-2, and in turn fat-7 indirectly inhibits acs-2 and other genes also involved in beta-oxidation (PubMed:15719061). As part of a lysosome-to-nucleus retrograde lipid signaling pathway, acting in concert with nuclear hormone receptor nhr-80, activates the transcription of genes promoting longevity and mitochondrial beta-oxidation (PubMed:25554789, PubMed:26671266). In concert with nuclear hormone receptor nhr-66, involved in regulating target genes with roles in sphingolipid breakdown and lipid remodeling (PubMed:22511885). Also involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptors nhr-13 and nhr-80 (PubMed:22511885). Plays a role in modulating mitochondrial morphology and function (PubMed:22511885). Plays a role in transgenerational lipid accumulation in response to a high-fat diet (PubMed:35140229).
messages: RNAi-mediated knockdown eliminates the effect of C11 or C12 chain fatty acids in activating fat-7 expression and blocks overexpression of fat-7 in acdh-11 mutants (PubMed:25981666). Increased ratio of stearic acid to oleic acid (C18:0/C18:1n9) (PubMed:15719061). Drastically reduces life span (PubMed:15719061, PubMed:25554789).
messages: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

6239:CELE F37E3.1
gene id: 6239:CELE_F37E3.1
uniprot id: O01763
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NCBP1 family.
messages: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp-1 and ncbp-1 that interacts with m7GpppG-capped RNA.
messages: Lethality in 63% of embryos.
messages: Nucleus

6239:CELE F58A6.4
gene id: 6239:CELE_F58A6.4
uniprot id: Q20958
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE T25B9.7
gene id: 6239:CELE_T25B9.7
uniprot id: Q22770
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C45B2.4
gene id: 6239:CELE_C45B2.4
uniprot id: Q2WF65
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K07C6.4
gene id: 6239:CELE_K07C6.4
uniprot id: O44650
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE T03G11.8
gene id: 6239:CELE_T03G11.8
uniprot id: Q22125
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in head and tail body wall muscles.
messages: No visible phenotype (PubMed:19737747, PubMed:22829780). No defect in the positioning of ASI and ASH neuron cell bodies (PubMed:22829780). No defect in the positioning of PQV, PVP, RMEV, HSN adn AVK axons in the ventral nerve cord (PubMed:19737747).
messages: Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.
messages: Secreted

6239:CELE R74.6
gene id: 6239:CELE_R74.6
uniprot id: P50444
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

6239:CELE C05E11.4
gene id: 6239:CELE_C05E11.4
uniprot id: P54145
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Involved in the uptake of ammonia.
messages: Membrane

6239:CELE C33D12.3
gene id: 6239:CELE_C33D12.3
uniprot id: Q21467
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F57B7.4
gene id: 6239:CELE_F57B7.4
uniprot id: Q20930
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: First expressed in late embryos and continues through the adult stage. Observed on the surface of gonad, starting when distal tip cells migrate over the lateral hypodermis toward the dorsal muscles.
messages: Metalloprotease (PubMed:17491590, PubMed:18637819). Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis (PubMed:10864868, PubMed:15556863, PubMed:17491590,PubMed:19104038, PubMed:24318535, PubMed:26994289). Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane (PubMed:19104038). During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length (PubMed:26994289). Does not recruit fbl-1 to the pharynx basement membrane (PubMed:26994289).
messages: N-glycosylated by the COG complex; required for gonadal localization (PubMed:14688791, PubMed:16354716, PubMed:17761667, PubMed:17491590). N-glycosylation of the propeptide is required for gonadal localization but not for distal tip cell migration (PubMed:17491590). Required for the regulation of pharynx length (PubMed:26994289). N-glycosylation is not required for mig-17 secretion (PubMed:17491590).
messages: Secreted from muscle cells and functions in the basement membrane of the gonad to guide DTC migration (PubMed:10864868, PubMed:24318535). Localizes to the pharyngeal basement membrane (PubMed:26994289).
messages: The PLAC domain is required for distal tip cell migration but not for gonadal localization.
messages: The disintegrin domain is required for distal tip cell migration and partially for mig-17 localization to the gonad (PubMed:17491590). Required for the control of pharynx length (PubMed:26994289).
messages: The precursor is cleaved into the active mature form by autoproteolysis (PubMed:17491590, PubMed:18637819). Cleavage occurs after secretion and only during the L3-L4 larval stages (PubMed:18637819).
messages: The propeptide is required for localization to the gonad basement membrane.
messages: basement membrane

6239:CELE W09G3.8
gene id: 6239:CELE_W09G3.8
uniprot id: Q7YTG6
names: Similarity
messages: Belongs to the YOS1 family.

6239:CELE M03A8.1
gene id: 6239:CELE_M03A8.1
uniprot id: Q21481
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

6239:CELE ZK688.2
gene id: 6239:CELE_ZK688.2
uniprot id: P34672
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE H20J04.8
gene id: 6239:CELE_H20J04.8
uniprot id: Q9BLB6
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.
messages: Interacts with rnp-3.
messages: Nucleus
messages: Reduced rate of growth. Embryonic lethal. Mog-2 and rnp-3 double mutants show arrested larval development at L2, without showing signs of oogenesis or spermatogenesis and increased rates of embryonic lethality.
messages: This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing.

6239:CELE F26D10.10
gene id: 6239:CELE_F26D10.10
uniprot id: Q9XVU2
names: Similarity
messages: Belongs to the glutamine synthetase family.

6239:CELE C28A5.4
gene id: 6239:CELE_C28A5.4
uniprot id: Q18273
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the distal-less homeobox family.
messages: Expressed in dopaminergic neurons throughout the life of the neurons.
messages: Nucleus
messages: Predominantly expressed in the head hypdodermis, neuronal support cells and CAN neurons.
messages: Probable transcription factor (PubMed:23788625). Binds to the sequence motif 5'-ATAAT-3' in regulatory elements (PubMed:23788625). Required for development of the anterior hypodermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability (PubMed:11747075). Modulates and maintains dopaminergic neuron differentiation (PubMed:23788625). May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-40 and ceh-20 (PubMed:23788625).

6239:CELE H27M09.4
gene id: 6239:CELE_H27M09.4
uniprot id: G5EEB6
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y38C1AA.4
gene id: 6239:CELE_Y38C1AA.4
uniprot id: Q9N428
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: May act synergistically with the Wnt pathways to control T-cell fate specification, gonad development, and P12 cell fate specification. Required for the distribution of pop-1 and tlp-1 proteins.
messages: Nucleus
messages: Strongly expressed in the cytoplasm of the pharynx muscle cells and several head neurons, probably the IL1s or IL2s, throughout development. Also expressed in some other unidentified neurons in the tail region. Weakly expressed in the nuclei of the T-cells and the T-cell daughters. Not expressed in gonads and in P12 cell.

6239:CELE Y71G12B.27
gene id: 6239:CELE_Y71G12B.27
uniprot id: Q95XM4
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

6239:CELE DY3.1
gene id: 6239:CELE_DY3.1
uniprot id: O45319
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim-8/ddp-1 and 3 copies of tin-13/tim-13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim-22 (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim-8-tim-13 complex mediates the import of some proteins while the predominant tim-9/tin-9.1-tim-10/tin-10 70 kDa complex mediates the import of much more proteins (By similarity).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tin-13/tim-13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

6239:CELE ZK1248.7
gene id: 6239:CELE_ZK1248.7
uniprot id: D9N120
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE T08D2.1
gene id: 6239:CELE_T08D2.1
uniprot id: A4F319
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6239:CELE C47C12.6
gene id: 6239:CELE_C47C12.6
uniprot id: P24585
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane
messages: Probable sodium channel subunit. Required by a subset of neurons.

6239:CELE ZC404.10
gene id: 6239:CELE_ZC404.10
uniprot id: Q23292
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y82E9BR.18
gene id: 6239:CELE_Y82E9BR.18
uniprot id: Q9BKR5
names: Similarity
messages: Belongs to the NEMF family.

6239:CELE C24A11.9
gene id: 6239:CELE_C24A11.9
uniprot id: P91093
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

6239:CELE F42G9.7
gene id: 6239:CELE_F42G9.7
uniprot id: K8FE10
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per C2 domain.
messages: Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.
messages: Cytoplasmic vesicle
messages: Defecation abnormalities.
messages: Expressed throughout the intestine and in several neurons in the head and tail.

6239:CELE F35G8.2
gene id: 6239:CELE_F35G8.2
uniprot id: Q1W0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE ZK370.3
gene id: 6239:CELE_ZK370.3
uniprot id: Q02328
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: RNAi-mediated knockdown causes a reduction in progeny numbers and a lengthening of the defecation cycle. Touch responses are normal. Expression of poly-Q 128Q (128Q consists of the first 57 amino acids of human HTT with a 28 Gln residue expansion) in RNAi-mediated knockdown animals causes a more severe reduction in touch response compared to wild type expressing 128Q.
messages: Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle.
messages: cytoskeleton

6239:CELE T25B6.7
gene id: 6239:CELE_T25B6.7
uniprot id: O45813
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F32H2.9
gene id: 6239:CELE_F32H2.9
uniprot id: P91873
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6239:CELE C25F9.2
gene id: 6239:CELE_C25F9.2
uniprot id: O62074
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

6239:CELE H16O14.1
gene id: 6239:CELE_H16O14.1
uniprot id: C0KDV0
uniprot id: G5EEC9
uniprot id: H2KZC2
uniprot id: H2KZC3
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T02C5.1
gene id: 6239:CELE_T02C5.1
uniprot id: H2L0K1
uniprot id: Q22095
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y73E7A.7
gene id: 6239:CELE_Y73E7A.7
uniprot id: Q9GUM2
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3 and bre-5.
messages: Membrane
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein.

6239:CELE Y106G6E.1
gene id: 6239:CELE_Y106G6E.1
uniprot id: G5EFV1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6239:CELE F59B2.13
gene id: 6239:CELE_F59B2.13
uniprot id: A0A1N7SYQ7
uniprot id: P34488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE F49C12.6
gene id: 6239:CELE_F49C12.6
uniprot id: Q20583
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

6239:CELE F54G8.2
gene id: 6239:CELE_F54G8.2
uniprot id: Q03603
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels.
messages: Monomer.
messages: Slow to adapt to new temperature levels. Dgk-3 and dgk-1 double mutant shows defects in olfactory adaptation.

6239:CELE T02D1.6
gene id: 6239:CELE_T02D1.6
uniprot id: A0A0K3AS23
uniprot id: A0A0K3AXD3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6239:CELE B0272.4
gene id: 6239:CELE_B0272.4
uniprot id: P41942
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Peroxisome

6239:CELE C37F5.1
gene id: 6239:CELE_C37F5.1
uniprot id: G5EDL0
uniprot id: U4PLN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

6239:CELE K04H4.1
gene id: 6239:CELE_K04H4.1
uniprot id: P17139
names: Disruption Phenotype
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
messages: At 20 degrees Celsius, there is reduced axon regeneration following injury in D-type motor neurons in temperature-sensitive mutant embryos.
messages: Belongs to the type IV collagen family.
messages: Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons (PubMed:25080592). May play a role in axon regeneration in embryos following injury in D-type motor neurons (PubMed:27984580).
messages: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
messages: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
messages: Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.
messages: Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
messages: basement membrane

6239:CELE F54F7.7
gene id: 6239:CELE_F54F7.7
uniprot id: Q20794
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

6239:CELE F14B4.3
gene id: 6239:CELE_F14B4.3
uniprot id: Q27493
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

6239:CELE Y67A10A.8
gene id: 6239:CELE_Y67A10A.8
uniprot id: A0A061ACE6
uniprot id: Q9U1V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE F52A8.2
gene id: 6239:CELE_F52A8.2
uniprot id: Q20636
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat G protein beta family.
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10 and eat-16 (PubMed:11333232).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in regulating dopamine-mediated locomotion behavior (PubMed:15378064).

6239:CELE F01F1.13
gene id: 6239:CELE_F01F1.13
uniprot id: G1FC92
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Glycosylated via C-mannosylation by dpy-19 at Trp-58 and Trp-61.
messages: Membrane
messages: Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left-side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration.

6239:CELE B0035.2
gene id: 6239:CELE_B0035.2
uniprot id: Q17433
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

6239:CELE Y51A2D.17
gene id: 6239:CELE_Y51A2D.17
uniprot id: G5EEL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE W03G9.4
gene id: 6239:CELE_W03G9.4
uniprot id: O44750
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11606206, PubMed:25905034). Has activity towards the flp-9 neuropeptide KPSFVRF-amide (PubMed:11606206).
messages: Cytoplasm
messages: Expressed in intestine from larval stage L2 onwards. Not detected in embryos.
messages: Homodimer (PubMed:25905034). May interact with pid-2, pid-4 and pid-5 (PubMed:33231880).
messages: Specifically expressed in the intestine.
messages: Strongly inhibited by the metal ion chelators EDTA and 1,10-phenanthroline (PubMed:11606206). Also inhibited by apstatin (PubMed:11606206, PubMed:25905034). Activity towards bradykinin is inhibited by Mn(2+) and Zn(2+) at all concentrations tested, whereas Co(2+) is inhibitory at concentrations above 100 uM and activatory at 10 uM (PubMed:11606206).

6239:CELE C09G12.8
gene id: 6239:CELE_C09G12.8
uniprot id: Q03206
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Rho family.
messages: Cell membrane
messages: Colocalizes with pak-1 to hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis.
messages: In the second generation, there is defective mitotic spindle orientation in the EMS and ABar blastomeres which results in disrupted left-right asymmetry and failure to undergo morphogenesis (PubMed:20126385). Due to defective apoptotic cell clearance, embryos accumulate apoptotic cell corpses (PubMed:20126385). Distal tip cell migratory defects (PubMed:26292279). Double knockout with unc-5 RNAi suppresses the distal tip cell migratory defect in the ced-10 single mutant (PubMed:26292279).
messages: Interacts (GTP-bound form) with pak-1 (PubMed:8824291). May interact (GTP-bound form) with mig-10 (via Ras-associating and PH domains) (PubMed:18499456).
messages: Most abundant at embryonic stage, its expression decreases dramatically during development.
messages: Required in engulfing to control the phagocytosis of apoptotic cell corpses (PubMed:10707082, PubMed:20126385). Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:20126385). Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291). ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces (PubMed:10707082). Plays a redundant role with mig-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. May regulate these 2 processes by activating pak-1 and/or max-2 (PubMed:17050621). Plays a role, probably via mig-10, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. Regulates mig-10 asymmetric distribution in HSN neurons (PubMed:18499456). During the dorso-ventral axonal guidance and outgrowth of VD neurons, required together with mig-2 to inhibit growth cone filopodial protrusion mediated by netrin guidance cue unc-6 and its receptors unc-5 and unc-40 (PubMed:25371370, PubMed:30045855). Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and, together with mig-2, by restricting plus-end microtubule accumulation in the growth cone (PubMed:30045855). Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382). During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419). Furthermore, plays a role in distal tip cell polarity and migration by negatively regulating the unc-6/Netrin receptor unc-5 (PubMed:26292279). May be involved in signal transduction during cell migration (PubMed:10…

6239:CELE Y46H3C.2
gene id: 6239:CELE_Y46H3C.2
uniprot id: A0A0K3ASH0
uniprot id: Q9N4V9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T06D8.6
gene id: 6239:CELE_T06D8.6
uniprot id: P53703
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Mitochondrion inner membrane
messages: Probable lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.

6239:CELE B0240.1
gene id: 6239:CELE_B0240.1
uniprot id: Q17463
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

6239:CELE Y42H9B.1
gene id: 6239:CELE_Y42H9B.1
uniprot id: Q9N3X9
names: Similarity
messages: Belongs to the cuticular collagen family.

6239:CELE ZK185.5
gene id: 6239:CELE_ZK185.5
uniprot id: Q3V5H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

6239:CELE Y51B9A.4
gene id: 6239:CELE_Y51B9A.4
uniprot id: Q9XXC4
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE T04H1.6
gene id: 6239:CELE_T04H1.6
uniprot id: Q22179
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C17D12.3
gene id: 6239:CELE_C17D12.3
uniprot id: G5EFH6
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE AH9.2
gene id: 6239:CELE_AH9.2
uniprot id: Q10905
names: Function
messages: Involved in the degradation of chromosomal DNA. Contributes to cell killing.

6239:CELE W03D8.2
gene id: 6239:CELE_W03D8.2
uniprot id: O45001
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE D1046.1
gene id: 6239:CELE_D1046.1
uniprot id: Q18937
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y111B2A.13
gene id: 6239:CELE_Y111B2A.13
uniprot id: Q9NEX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha, a beta and a gamma subunit.

6239:CELE F08H9.5
gene id: 6239:CELE_F08H9.5
uniprot id: Q19231
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F44B9.5
gene id: 6239:CELE_F44B9.5
uniprot id: P34426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AUP1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet

6239:CELE Y39A3B.4
gene id: 6239:CELE_Y39A3B.4
uniprot id: Q9N519
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F36A4.7
gene id: 6239:CELE_F36A4.7
uniprot id: P16356
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Chromosome
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits (By similarity). Interacts with sig-7 (PubMed:27541139).
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity). Involved in the transcription of several genes including those involved in embryogenesis (PubMed:14726532, PubMed:27541139).
messages: Expressed in embryo. During embryonic development, the form phosphorylated at 'Ser-2' of the C-terminal heptapeptide repeats is present only in transcriptionally active somatic cells.
messages: Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is polyubiquitinated via 'Lys-63'-linkages on Lys-1260 at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription-coupled nucleotide excision repair (TC-NER) machinery. Subsequent DEF1-dependent polyubiquitination by the elongin complex via 'Lys-48'-linkages may lead to proteasome-mediated degradation; presumably at stalled RNA pol II where TC-NER has failed, to halt global transcription and enable 'last resort' DNA repair pathways.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic arrest at the 100-cell stage and prevents the embryonic transcription of several genes (PubMed:14726532). Surviving embryos exhibit gastrulation defects with decreased expression of genes involved in gastrulation (PubMed:27541139).
messages: The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.
messages: The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.
messages: The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II (By similarity). Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat and starts at the 3- to 4-cell embryonic stage (PubMed:14726532, PubMed:17291483). This phosphorylation also occurs in the early stages of oocyte development and is not detected in oocytes arrested at the meiotic diakinesis stage (PubMed:17291483). In the somatic lineage, phosphorylation at 'Ser-2' is mediated by cdk-12 downstream of cdk-9 whereas in the germline lineage cdk-12 phosphorylates 'Ser-2' independently of cdk-9 (PubMed:23903194). Phosphorylation is likely mediated by cdk-7 (PubMed:11960010). May be dephosphorylated by fcp-1 in diakinetic oocytes and in 1-cell and 2-cell embryos (PubMed:17291483). Dephosphorylated at 'Ser-5' of the heptapeptide repeats by ssup-72 (PubMed:26588990). The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed (By similarity).

6239:CELE C09E7.3
gene id: 6239:CELE_C09E7.3
uniprot id: Q9N5Z2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in DD and VD GABAergic motor neurons (PubMed:26387713, PubMed:26083757). Expressed in a subset of head neurons including M2 motor neurons in the pharynx (PubMed:26387713, PubMed:26083757). Expressed in coelomocytes (PubMed:26387713).
messages: Membrane
messages: Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons (PubMed:26387713, PubMed:26083757). Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr-12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation (PubMed:26387713).
messages: Transiently expressed in DD GABAergic motor neurons in embryos and during larval stage L1, with expression decreasing as development proceeds (PubMed:26387713, PubMed:26083757). Expressed strongly in VD GABAergic motor neurons from the end of larval stage L1 onwards and in particular along the ventral nerve cord (PubMed:26387713, PubMed:26083757). Specifically expressed in DD GABAergic motor neurons in the dorsal and ventral nerve cords at larval stages L1 and L4 (PubMed:26387713).
messages: Viable with locomotory defects which may be attributed to impaired GABAergic motor neuron function (PubMed:26387713, PubMed:26083757). Hypersensitive to the drug aldicarb which may be indicative of abnormal GABAergic signaling (PubMed:26083757). Premature postsynaptic remodeling/formation of DD GABAergic motor neurons in animals at larval stage L1 with remodeling/formation occurring 8-16 hours posthatching as opposed to 14-18 hours posthatching in wild-type animals (PubMed:26387713). Mislocalization of postsynaptic proteins with increased dorsal to ventral translocation of the acr-12 receptor in VD GABAergic motor neurons at larval stages L2 and L4; leading to no acr-12 puncta in the dorsal nerve and probably contributing to improper formation of synaptic inputs and ectopic postsynaptic remodeling/formation of VD motor neurons (PubMed:26387713, PubMed:26083757). Abnormal ectopic clustering of the postsynaptic receptor unc-49 along the dorsal nerve cord of DD GABAergic motor neurons (PubMed:26083757). Abnormal clustering of the presynaptic proteins snb-1 and rab-3 along the dorsal nerve cord of DD GABAergic motor neurons (PubMed:26083757). Additionally, aberrant localization of presynaptic proteins in VD GABAergic motor neurons with increased puncta for presynaptic proteins including snb-1, rab-3 and syd-2 in the dorsal nerve cord, but fewer puncta in the ventral nerve cord at larval stages proceeding the L1 larval stage, probably indicative of impaired and ectopic presynaptic remodeling/formation (PubMed:26387713, PubMed:26083757).
messages: axon
messages: dendrite
messages: extracellular space

6239:CELE H04J21.2
gene id: 6239:CELE_H04J21.2
uniprot id: O44811
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE W03F8.5
gene id: 6239:CELE_W03F8.5
uniprot id: O44565
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

6239:CELE Y76A2A.2
gene id: 6239:CELE_Y76A2A.2
uniprot id: G5ED40
uniprot id: G5EE14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

6239:CELE C07G3.10
gene id: 6239:CELE_C07G3.10
uniprot id: Q965N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE ZK770.1
gene id: 6239:CELE_ZK770.1
uniprot id: O01635
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Cell membrane
messages: Homotrimer.
messages: Proton-gated cation channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized (By similarity). Has high selectivity for sodium ions and can also transport lithium ions with high efficiency (By similarity). Can also transport potassium ions, but with lower efficiency (By similarity). It is nearly impermeable to the larger rubidium and cesium ions (By similarity). Promotes synaptic vesicle fusion to positively regulate the release of dopamine at dopaminergic neuron synapses (PubMed:31494966).

6239:CELE C53B4.7
gene id: 6239:CELE_C53B4.7
uniprot id: Q18801
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (PubMed:16650000). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5 (PubMed:10924467, PubMed:17135259, PubMed:17482642). Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds (PubMed:20062796). Has a role in determining brood size (PubMed:10924467).
messages: Expressed throughout development, showing up-regulation between stages L2 and L4.
messages: Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein. Mutants also have reduced brood sizes at only 12% of wild-type N2.

6239:CELE R06C7.1
gene id: 6239:CELE_R06C7.1
uniprot id: Q21770
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts.
messages: Belongs to the Argonaute family. WAGO subfamily.
messages: Cytoplasmic granule
messages: Enriched in sperm and oocytes.
messages: Interacts with rde-12 (PubMed:24684931). Interacts with znfx-1 (PubMed:29775580).
messages: Members of the WAGO (worm-specific argonaute) subfamily lack conserved metal-binding residues found in other argonaute proteins and probably do not cleave target mRNAs directly.

6239:CELE T24F1.3
gene id: 6239:CELE_T24F1.3
uniprot id: Q22744
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in the pharynx, epithelial cells, ciliated neurons in the head, body wall muscles, hypodermis, vulva, gonadal sheath cells, tail hypodermis and in coelomocytes.
messages: Expressed in the pharynx, neurons and vulva.
messages: In embryos, expressed in epidermal cells during the dorsal intercalation and ventral enclosure.
messages: Interacts with rab-39 (GTP-bound form) (PubMed:23294242). Interacts (via SARAH domain) with cst-1; the interaction is required for the phosphorylation of cst-1 (PubMed:23103556).
messages: Involved in embryonic morphogenesis (PubMed:23103556). Plays a role in the organization of apical filamentous actin in epithelial cells of the developing embryo (PubMed:23103556). May play a role in let-60-mediated vulval development (PubMed:23103556). May induce nuclear condensation (PubMed:23103556). Positively regulates the oxidative stress response, and this may be in association with the small GTPase rab-39 (PubMed:23294242). Not required for muscle integrity (PubMed:23103556).
messages: RNAi-mediated knockdown results in reduced survival in response to oxidative stress induced by sodium arsenite.
messages: cytoskeleton

6239:CELE F40E10.3
gene id: 6239:CELE_F40E10.3
uniprot id: Q20203
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

6239:CELE Y59A8B.20
gene id: 6239:CELE_Y59A8B.20
uniprot id: G5EGH7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Expressed in the hypodermal regions hyp4 and hyp7 from the comma stage of embryogenesis and subsequently throughout development.
messages: Mutants display an increased body growth rate during larval development and male tail morphological defects characterized by thickening of the male rays, with rays 5 and 6 the most severely affected in most cases. RNAi-mediated knockdown results in increased body length.
messages: Secreted
messages: Secreted protein that is involved in larval elongation, early adult growth and male tail development.

6239:CELE Y43F4A.1
gene id: 6239:CELE_Y43F4A.1
uniprot id: O62446
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M8 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Essential for the coordination of mitotic progression, and also plays a role in cell migration.

6239:CELE E02H1.4
gene id: 6239:CELE_E02H1.4
uniprot id: Q09525
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Inhibited by N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide HCl (PJ34), 1,5-dihydroxyisoquinoline (DHQ) and 3-aminobenzamide (3AB).
messages: Nucleus
messages: Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.
messages: Predominantly expressed at early embryonic stages and later in L4 and adult stages.

6239:CELE F28H7.10
gene id: 6239:CELE_F28H7.10
uniprot id: G5EDR9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T06A1.5
gene id: 6239:CELE_T06A1.5
uniprot id: O61929
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE R08E5.2
gene id: 6239:CELE_R08E5.2
uniprot id: O01592
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Homodimer.
messages: Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide.

6239:CELE M04C7.1
gene id: 6239:CELE_M04C7.1
uniprot id: P91907
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

6239:CELE C15H11.9
gene id: 6239:CELE_C15H11.9
uniprot id: Q9XVT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: nucleolus

6239:CELE Y53C10A.12
gene id: 6239:CELE_Y53C10A.12
uniprot id: G5EFT5
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the HSF family.
messages: Cytoplasm
messages: Expressed in intestinal cells, body wall muscle cells, and hypodermal cells, as well as many neurons in the head and tail.
messages: Forms homodimers and homotrimers (PubMed:29042483, PubMed:22265419). Component of the DHIC (ddl-1-containing hsf-1 inhibitory complex), which contains at least ddl-1, ddl-2, hsb-1 and hsf-1 (PubMed:22265419). Within the complex, interacts with ddl-1 (PubMed:22265419). Formation of the DHIC may be dependent upon the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:22265419).
messages: Functions as a stress-inducible and DNA-binding transcription factor, playing a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:29042483, PubMed:15611166, PubMed:22265419). Upon exposure to heat and other stress stimuli, activates gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of target genes, such as the HSPs (PubMed:29042483, PubMed:27688402, PubMed:15611166, PubMed:22265419). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences in HSEs (PubMed:29042483, PubMed:27688402). Involved in positive modulation of expression of heat shock protein hsp-16.2 in response to heat shock; may act in concert with homeodomain-interacting protein kinase hpk-1 (PubMed:15611166, PubMed:28198373, PubMed:29036198). In response to heat shock or starvation, required for the modulation of lifespan, and protection against aberrant protein aggregation proteotoxicity; may act in parallel with the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:15611166, PubMed:18331616, PubMed:28198373, PubMed:29036198). Plays a role in modulating autophagy, in response to a moderate and short-term heat shock, also known as a hormetic heat shock (PubMed:28198373). Involved in positive modulation of ascaroside pheromone biosynthesis in response to heat shock, perhaps by directly activating transcription of peroxisomal fatty acid beta-oxidation genes (PubMed:26759377). Required in modulating the response to infection by either Gram-negative or Gram-positive bacteria, perhaps acting via regulation of expression of Hsp90/daf-21 and members of the small heat shock protein (HSP20) family (PubMed:16916933, PubMed:29042483). May play a role downstream of the daf-16/FOXO and daf-2 signaling pathway in response to bacterial pathogens (PubMed:16916933). Modulates …
messages: Induced by heat shock.
messages: Nucleus
messages: Phosphorylated.
messages: RNAi-mediated knockdown increases susceptibility to Gram-negative bacterium P.aeruginosa in wild-type and in a daf-2 mutant background (PubMed:16916933). Abolishes both median and maximum lifespan extension caused by starvation (PubMed:18331616). Fails to prevent paralysis due to proteotoxicity under starvation conditions (PubMed:18331616). Prevents the heat shock-induced increase in lgg-1/Atg8 punctae in body-wall muscles, nerve ring neurons and proximal intestinal cells (PubMed:28198373). Accelerates death upon exposure to the Gram-negative bacterium P.aeruginosa PA14 (PubMed:29042483).
messages: Sumoylated (PubMed:29036198). Sumoylation may inhibit transcriptional activity in response to heat shock (PubMed:29036198).

6239:CELE B0331.2
gene id: 6239:CELE_B0331.2
uniprot id: O45220
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

6239:CELE F55F8.9
gene id: 6239:CELE_F55F8.9
uniprot id: G4SKK4
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T05A1.2
gene id: 6239:CELE_T05A1.2
uniprot id: Q22183
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F18F11.5
gene id: 6239:CELE_F18F11.5
uniprot id: Q86ME2
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Although the residues involved in the catalytic activity are absent, suggesting that the kinase is inactive, some kinase activity has been detected.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
messages: Expressed in vulval and body wall muscles, hypodermis, seam cells and tissues next to pharynx and anus.
messages: Membrane
messages: Negatively regulates lifespan and health span probably by participating in nutrient sensing.
messages: RNAi-mediated knockdown causes an increase in lifespan of about 60 percent compared to wild type but only when done at an early larval stage. Lifespan increase is associated with a decrease in the accumulation of the age pigment lipofuscin, a delayed age-onset nuclear membrane disintegration in muscles and loss of mobility. In addition, causes an increase in lipid catabolism resulting in fewer fat droplets in intestinal cells and hypodermis and lower triglycerides levels. Transcriptional up-regulation of genes involved in fatty acid degradation and in xenobiotic detoxification and decrease in cellular oxygen reactive species (ROS) production. Low brood size, longer reproductive span, increased autophagosome formation in seam cells and smaller body size. Normal pharyngeal pumping and feeding rate. RNAi-mediated knockdown in muscles or hypodermis causes a moderate increase in lifespan.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE T03E6.6
gene id: 6239:CELE_T03E6.6
uniprot id: O45739
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE ZC168.4
gene id: 6239:CELE_ZC168.4
uniprot id: Q10653
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin AB subfamily.
messages: Cytoplasm
messages: Essential for the control of the cell cycle at the G2/M (mitosis) transition.
messages: Expressed in mature oocytes followed by a severe reduction in protein levels as meiotic division progresses (PubMed:23578927).
messages: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF) (By similarity). The cyclin subunit imparts substrate specificity to the complex (By similarity). Interacts with E3 ubiquitin-protein ligase etc-1 (PubMed:23578927).
messages: Ubiquitinated by etc-1 likely during meiosis, resulting in its degradation.

6239:CELE M05B5.5
gene id: 6239:CELE_M05B5.5
uniprot id: G5EEG9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: During male tail development, expressed in each of the nine Rn cells and in the anterior daughter cell, the ray neuroblast (at protein level) (PubMed:11076762). First expressed at the comma stage of embryogenesis (PubMed:19632181). Expressed asymmetrically, in the mother cell of the MI pharyngeal motorneuron but not in the mother cell of the e3D epithelial cell (PubMed:21041366). Expressed during hermaphrodite gonadogenesis, in the two somatic gonadal progenitor (SGP) cells, Z1.ppp and Z4.aaa, precursors to the anchor cell (AC) and the ventral uterine precursor cell (VU), but not detected in their sister cells, Z1.ppa and Z4.aap (PubMed:14701877, PubMed:19376107, PubMed:21784067). Expressed in both pre-AC and pre-VU cells, and after the AC/VU decision, expression is reduced in the VU and its descendants; however, expression persists in the AC through the time of basement membrane invasion (PubMed:21784067, PubMed:31402303). Expressed in the gonadal distal tip cells (DTCs) throughout development and in adults (PubMed:19376107).
messages: Interacts with helix-loop-helix protein ngn-1; the interaction is direct (PubMed:21041366). Efficient DNA binding probably requires dimerization with another helix-loop-helix protein (PubMed:19632181, PubMed:11076762). Forms a heterodimer with helix-loop-helix protein hlh-12 (PubMed:17588558). Forms a heterodimer with lin-32 (PubMed:11076762). May form a heterodimer with hlh-10 (PubMed:19632181).
messages: Nucleus
messages: RNAi-mediated knockdown in the early larval L1 stage causes both somatic gonadal progenitor (SGP) cells, Z1.ppp and Z4.aaa, to assume the ventral uterine precursor cell (VU) identity; whereas, if RNAi is applied during the late larval L1 stage, or at the larval L2 stage, both assume the anchor cell (AC) identity (PubMed:21784067, PubMed:14701877). RNAi-mediated knockdown applied at the time of the larval stage L1/L2 molt causes defects in invasion of the basement membrane by the AC (PubMed:21784067). RNAi-mediated knockdown causes the MI pharyngeal motorneuron to transform into an e3D-like epithelial cell (PubMed:21041366). RNAi-mediated knockdown reduces expression of alpha integrin ina-1 and of ADAMTS protease gon-1, and causes defects in migration of the gonadal distal tip cells (DTCs) (PubMed:25982859, PubMed:17588558). RNAi-mediated knockdown causes reduction in the number of hermaphrodites with DTCs, diminishes formation of elongated gonadal arms and reduces expression of lag-2 (PubMed:19376107). RNAi-mediated knockdown during larval stage L3 causes a subsequent three-fold reduction in germ cell number in the adult hermaphrodite gonad (PubMed:19376107). RNAi-mediated knockdown increases lifespan, reduces fertility, improves the response to proteotoxic stress, alters the response to reactive oxygen species (ROS) and reduces expression of arginine kinases such as argk-1 (PubMed:32203922).
messages: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:19632181, PubMed:11076762, PubMed:14701877). Plays a key role in the anchor cell/ventral uterine precursor cell (AC/VU) decision; required for VU fate (PubMed:14701877, PubMed:31402303). Regulates expression of lin-12/Notch receptor and putative ligand lag-2 in the presumptive AC and presumptive VU cells (PubMed:31402303). Modulates expression of lag-2 in the gonadal distal tip cells (DTCs) (PubMed:14701877, PubMed:19376107). Involved in formation of the polarised cell membrane of the AC and thus facilitates invasion across the gonadal basement membrane, acting via transcriptional modulation of multiple genes (PubMed:21784067). Involved in specification of the hermaphrodite DTC and the male linker cell, perhaps acting in concert with the homeobox protein, ceh-22 (PubMed:19376107). Plays a role in regulation of migration of DTCs and the modulation of expression of alpha integrin ina-1 and ADAMTS protease gon-1 (PubMed:25982859, PubMed:17588558). Required for DTC maintenance, and for function of the DTC as a niche for germline stem cells (PubMed:19376107). Plays a role in cell-autonomously establishing a neuronal left-right asymmetry (PubMed:21041366). Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:11076762). Negatively modulates lifespan, perhaps acting by regulating expression of arginine kinases, which in turn results in altered metabolism and homeostasis of reactive oxygen species (ROS) (PubMed:32203922).

6239:CELE Y53C12A.2
gene id: 6239:CELE_Y53C12A.2
uniprot id: O18210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

6239:CELE C30G4.4
gene id: 6239:CELE_C30G4.4
uniprot id: A0A078BPF7
uniprot id: A0A078BPG4
uniprot id: A0A078BPG8
uniprot id: A0A078BPH7
uniprot id: A0A078BPI1
uniprot id: A0A078BPI6
uniprot id: A0A078BPJ1
uniprot id: A0A078BQJ7
uniprot id: A0A078BQK0
uniprot id: A0A078BQK4
uniprot id: A0A078BS39
uniprot id: A0A078BS43
uniprot id: A0A078BS47
uniprot id: A0A078BTK3
uniprot id: A0A078BTK6
uniprot id: A0A078BTK9
uniprot id: H2KYK2
uniprot id: H2KYK3
uniprot id: Q65ZH8
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

6239:CELE K10B3.8
gene id: 6239:CELE_K10B3.8
uniprot id: P17329
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.
messages: There are four nearly identical glyceraldehyde 3-phosphate dehydrogenases in Caenorhabditis elegans.

6239:CELE Y43F8C.7
gene id: 6239:CELE_Y43F8C.7
uniprot id: Q9XWP1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC10 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

6239:CELE F13A7.13
gene id: 6239:CELE_F13A7.13
uniprot id: Q7YTN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE T22F3.4
gene id: 6239:CELE_T22F3.4
uniprot id: A0A131MBQ6
uniprot id: Q94300
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm
messages: Mutants have an extended lifespan, increased volume and are sterile with a germ cell proliferation defect.
messages: Nucleus
messages: There's a functional difference between the two L11-encoding proteins in C.elegans. rpl-11.1 plays a role in the germline whereas rpl-11.2 has a somatic function.

6239:CELE F32D8.13
gene id: 6239:CELE_F32D8.13
uniprot id: I2HAD9
uniprot id: Q86NH2
names: Subcellular Location Annotation
messages: cytosol

6239:CELE D2005.3
gene id: 6239:CELE_D2005.3
uniprot id: Q93408
names: Similarity
messages: Belongs to the PDCD5 family.

6239:CELE Y71H2B.6
gene id: 6239:CELE_Y71H2B.6
uniprot id: Q9N4F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE ZC482.5
gene id: 6239:CELE_ZC482.5
uniprot id: G5ECN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C36A4.9
gene id: 6239:CELE_C36A4.9
uniprot id: Q18496
uniprot id: Q65ZB8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6239:CELE R07C3.3
gene id: 6239:CELE_R07C3.3
uniprot id: O16776
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C47E12.1
gene id: 6239:CELE_C47E12.1
uniprot id: Q18678
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer (By similarity).

6239:CELE F39H2.1
gene id: 6239:CELE_F39H2.1
uniprot id: Q93702
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: SPSAKWMRF-amide: Acts as a ligand for the npr-22 receptor in vitro.
messages: Secreted

6239:CELE T28D9.7
gene id: 6239:CELE_T28D9.7
uniprot id: Q10025
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F07B10.5
gene id: 6239:CELE_F07B10.5
uniprot id: Q6BET0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F08A8.1
gene id: 6239:CELE_F08A8.1
uniprot id: O62140
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Activated by ATP (PubMed:27551084). ATP binding leads to a conformational change that promotes FAD cofactor binding and enzyme activity (PubMed:27551084). ATP binding likely occurs during acox-1.1 folding and/or dimer formation (PubMed:27551084).
messages: Belongs to the acyl-CoA oxidase family.
messages: Expressed in hypodermis and intestine.
messages: Homodimer (Probable). Forms a heterodimer with acox-1.2 (PubMed:25775534). Forms a heterodimer with acox-1.3; the interaction may be important for the stability of acox-1.3 (PubMed:25775534).
messages: Induced by high temperatures (25 degrees Celsius).
messages: Involved in the first step of peroxisomal beta-oxidation by catalyzing the desaturation of fatty acid-derived side chains (PubMed:25775534, PubMed:29537254, PubMed:27551084). Specifically, catalyzes the desaturation of fatty acids heptanoyl-CoA (C7), nonanoyl-CoA (C9), dodecanoyl-CoA (C12) and to a lesser extent pentanoyl-CoA (C5) and hexadecanoyl-CoA (C16), and hydroxylated fatty acid hydroxynonanoyl-CoA (PubMed:25775534, PubMed:29537254, PubMed:27551084). Also, catalyzes the desaturation fatty acid-derived side chains of ascaroside pheromones, which regulates development and behavior (PubMed:20610393, PubMed:25775534, PubMed:29537254, PubMed:29863473, PubMed:27551084). Specifically, shortens ascaroside with 5-carbon omega side chain (asc-omega-C5), 7-carbon side chain (asc-C7), 9-carbon side chain (asc-C9), 11-carbon side chain (asc-C11), 13-carbon side chain (asc-C13), 15-carbon side chain (asc-C15) and to a lesser extent ascarosides with 7-omega-carbon side chain (asc-omega-C7) (PubMed:25775534, PubMed:29537254, PubMed:27551084). Also shortens indol-3-carbonyl(IC)-ascarosides with 7-carbon side chain (IC-asc-C7) and to a lesser extent (IC)-ascarosides with 9-carbon side chain (IC-asc-C9) (PubMed:29863473). May associate and regulate the folding and/or the catalytic activity of other acyl-coenzyme A oxidases including acox-1.2, acox-1.3, acox-1.4 and acox-3 modulating the type of ascarosides produced (PubMed:25775534, PubMed:29537254, PubMed:29863473). In association with acox-1.3, catalyzes the desaturation of asc-C7-CoA but not of fatty acids or hydroxylated fatty acids (PubMed:25775534). Involved in the biosynthesis of asc-C6-MK (daumone 2) and asc-delta-C9 (daumone 3) but not asc-C7 (daumone 1); daumones are pheromones produced during unfavourable growth conditions which promote entry into the dauer stage (PubMed:20610393).
messages: Peroxisome
messages: RNAi-mediated knockdown abolishes production of dauer pheromone daumone 2, severely reduces production of daumone 3 and increases production of daumone 1.

6239:CELE C01B12.1
gene id: 6239:CELE_C01B12.1
uniprot id: O17209
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F09E5.5
gene id: 6239:CELE_F09E5.5
uniprot id: Q19262
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC6 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE B0035.16
gene id: 6239:CELE_B0035.16
uniprot id: Q17440
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
messages: During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of the wobble base (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, a transient disulfide bond is formed between the two active site cysteine residues (By similarity).
messages: Mitochondrion

6239:CELE C14B9.4
gene id: 6239:CELE_C14B9.4
uniprot id: P34331
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Chromosome
messages: Cytoplasm
messages: Embryos.
messages: Impaired protein polarity (PubMed:18316412, PubMed:20823068). Lengthened AB and P1 cell cycle times (PubMed:18316412, PubMed:20823068). RNAi-mediated knockdown causes defects in germline mitosis including cell-cylce arrest and formation of polyploid nuclei (PubMed:22018922). RNAi-mediated knockdown in plk-2 mutant background causes a loss in sun-1 phosphorylation at 'Ser-8' but not at 'Ser-12' (PubMed:22018922).
messages: Interacts with mex-5, mex-6 and spat-1.
messages: Midbody
messages: Nucleus
messages: Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca (PubMed:10660671). In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes (PubMed:10660671). Zygotic role in the development of the germline and nerve cord (PubMed:10660671). In mitotic cells, plays a role in spindle organization and centrosome maturation (PubMed:20823068). Involved in asymmetric nuclear localization of cdc-25.1 during embryogenesis which affects cell division timing (PubMed:18305005, PubMed:18316412, PubMed:20823068). Together with plk-2, regulates cytoplasm polarity in early embryos (PubMed:18199581, PubMed:18316412, PubMed:18305005). May play a minor role in chromosome pairing and synapsis during oocyte meiosis I (PubMed:22018922).
messages: The POLO box domains are involved in the asymmetric cytoplasmic localization.
messages: centrosome
messages: kinetochore

6239:CELE B0511.10
gene id: 6239:CELE_B0511.10
uniprot id: O61820
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

6239:CELE Y57A10A.35
gene id: 6239:CELE_Y57A10A.35
uniprot id: Q7YWQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6239:CELE T13F2.5
gene id: 6239:CELE_T13F2.5
uniprot id: Q94048
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y47H9C.2
gene id: 6239:CELE_Y47H9C.2
uniprot id: Q9XWD7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6239:CELE C25A1.11
gene id: 6239:CELE_C25A1.11
uniprot id: O02219
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Abnormal cell morphology of developing RMEL/R neurons. Arrested development at larvae life stage due to its requirement in the pharynx. Defects in SDQR neuron cell dorsal-ventral migration. Aggregation behavior is diminished. Abolishes guanylate cyclase gene expression in the URX neurons.
messages: Expressed in many cell types throughout development, including hypodermal cells, intestinal cells, pharyngeal cells, and neurons. Expressed in every cell during embryo.
messages: Interacts with hif-1 (PubMed:11427734). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:17628356, PubMed:9501178). Forms a heterodimer with ahr-1; binds DNA as heterodimer (PubMed:9501178). Forms a heterodimer with PAS domain-containing protein cky-1; binds DNA as heterodimer (PubMed:17628356).
messages: Nucleus
messages: Transcription factor (PubMed:17628356). Efficient DNA binding requires dimerization with another bHLH protein, such as cky-1 or ahr-1 (PubMed:17628356, PubMed:9501178). Regulates transcription of target genes, probably acting in complex with cky-1 (PubMed:17628356). Has a role in cellular differentiation (PubMed:9501178, PubMed:15136141). Required for pharyngeal development (PubMed:14757639). In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration (PubMed:14757639). Acts in the cellular response to hypoxia (PubMed:11427734). Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons (PubMed:16919260).

6239:CELE K07A1.12
gene id: 6239:CELE_K07A1.12
uniprot id: P90916
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (By similarity). Probable component of a NuRD-like complex, composed of at least lin-53 and hda-1 (PubMed:17075059). Interacts with lin-35 (PubMed:9875852). Interacts with hda-1; the interaction is direct (PubMed:9875852, PubMed:17075059). Component of the DRM complex, at least composed of lin-9, lin-35, lin-37, lin-52, lin-53, lin-54- dpl-1 and efl-1 (PubMed:17075059). Interacts with hcp-3 (PubMed:26904949).
messages: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation (PubMed:25446273, PubMed:26904949). Synthetic multivulva class B (synMuvB) protein (PubMed:9875852). SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:10704416, PubMed:17075059, PubMed:9875852).
messages: Decreased protein levels of DRM complex components including lin-9, lin-37, lin-52 and lin-54 (PubMed:17075059). Double knockout with the programmed cell death regulator mcd-1 results slow larval growth (PubMed:17237514). RNAi-mediated knockdown results in embryonic lethality (PubMed:9875852, PubMed:26904949). RNAi-mediated knockdown leads to a reduction of hcp-3 and his-1 protein levels and to a depletion of hcp-3 on centromeres and a reduction of H3K27me3 levels on metaphase chromosomes (PubMed:26904949). RNAi-mediated knockdown results in chromosome segregation defects during mitosis (PubMed:25446273, PubMed:26904949).
messages: Nucleus
messages: Ubiquitously expressed in embryos and newly hatched larvae. Expressed in all P(3-8).p vulval precursor cells at the time of vulval induction and until after all cell divisions and vulval morphogenesis are complete.
messages: centromere

6239:CELE F38B2.1
gene id: 6239:CELE_F38B2.1
uniprot id: P90901
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis.
messages: Forms some heteromeric filaments with ifb-1.
messages: Isoform d is abundantly expressed in the marginal cells of the pharynx, forming apicobasally oriented thick filament bundles that are attached to the apical and basal plasma membrane by hemi-adherens junctions. Expression of isoform c is also seen in the excretory cells and in the uterus. Isoform c is detectable in the amphid sensory neurins and the pharyngeal-intestinal valve. Both isoform c and isoform d are expressed in the rectum and vulva and in some neurons of the tail. In larvae, expression is seen in the excretory cell, the vulva, the rectum and in the thick filament bundles of the pharynx. Expression in pharynx begins in late embryos.

6239:CELE T27B7.3
gene id: 6239:CELE_T27B7.3
uniprot id: O16661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE M117.3
gene id: 6239:CELE_M117.3
uniprot id: Q21539
names: Similarity
messages: Belongs to the 14-3-3 family.

6239:CELE K01A2.1
gene id: 6239:CELE_K01A2.1
uniprot id: Q9TZ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

6239:CELE F07C3.7
gene id: 6239:CELE_F07C3.7
uniprot id: Q19151
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C32B5.7
gene id: 6239:CELE_C32B5.7
uniprot id: U4PEU2
uniprot id: U4PME4
uniprot id: U4PRP9
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE C35D10.10
gene id: 6239:CELE_C35D10.10
uniprot id: Q18484
names: Domain
names: Subcellular Location Annotation
messages: Membrane
messages: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
messages: The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity.

6239:CELE C42D4.6
gene id: 6239:CELE_C42D4.6
uniprot id: Q18567
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE EEED8.1
gene id: 6239:CELE_EEED8.1
uniprot id: Q09293
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively (PubMed:31147388, PubMed:31216475). Promotes the biogenesis of 21U-RNAs (PubMed:31216475). Required for chromosome segregation and cell division in early embryos (PubMed:17171368, PubMed:31216475). May have a role in DNA replication (PubMed:17171368).
messages: Component of the pid-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least pid-1, tofu-6, ife-3, pid-3, and erh-2, which is required for the biogenesis of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the pid-1 variant of the PETISCO complex interacts with pid-1 (PubMed:31216475). Component of the tost-1 variant of the PETISCO complex (also called the pid-3, erh-2, tofu-6, and ife-3 small RNA complex) containing at least tost-1, tofu-6, ife-3, pid-3, and erh-2, which plays an essential role in embryogenesis (PubMed:31147388, PubMed:31216475). Within the tost-1 variant of the PETISCO complex interacts with tost-1 (PubMed:31216475). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts (via C-terminus) with ife-3 (PubMed:31216475, PubMed:31147388). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts (via the RRM domain) with pid-3 (PubMed:31216475, PubMed:31147388). Within the pid-1 and tost-1 variants of the PETISCO complexes interacts (via the RRM domain) with erh-2 (PubMed:31216475). In contrast to the pid-1 variant of the PETISCO complex, the tost-1 variant of the PETISCO complex plays a minor role in the biogenesis of 21U-RNAs (PubMed:31147388).
messages: Cytoplasm
messages: Expressed both maternally and zygotically. Relatively high levels of expression in early embryos, weakly detectable in subsequent developmental stages and enriched in adults (at protein level) (PubMed:31147388). During early embryogenesis, expressed during prophase and interphase in 2- and 4-cell embryos (PubMed:31216475).
messages: Expression is restricted to the germline (at protein level).
messages: Nucleus
messages: Worms whose mothers are lacking mel-47 exhibit prolonged interphase between the two and four cell stages of development. Mutants arrest as early embryos ranging from 50 to 80 cells with no signs of morphogenesis. Chromatin bridges which connect nuclei remain present after cytokinesis appears complete. RNAi-mediated knockdown results in maternal effect lethal (Mel phenotype) (PubMed:31147388). RNAi-mediated knockdown results in chromosome segregation and cell division defects in early embryos (PubMed:31216475). RNAi-mediated knockdown results in defective activity of the PIWI-interacting RNA (piRNA) silencing pathway (PubMed:31147388). RNAi-mediated knockdown results in the failure of pid-1, pid-3 and erh-2 to localize to perinuclear granules, but instead they accumulate in the nucleus (PubMed:31216475).
messages: perinuclear region

6239:CELE B0432.3
gene id: 6239:CELE_B0432.3
uniprot id: P90993
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
messages: Mitochondrion

6239:CELE F35H10.6
gene id: 6239:CELE_F35H10.6
uniprot id: Q20070
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE ZC410.7
gene id: 6239:CELE_ZC410.7
uniprot id: A0A1N7SYX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

6239:CELE T23F2.1
gene id: 6239:CELE_T23F2.1
uniprot id: G5ECB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

6239:CELE Y54H5A.3
gene id: 6239:CELE_Y54H5A.3
uniprot id: Q9N394
names: Similarity
messages: Belongs to the RRM RBM42 family.

6239:CELE Y54G11A.6
gene id: 6239:CELE_Y54G11A.6
uniprot id: O61235
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the catalase family.
messages: Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable) (PubMed:25243607, PubMed:28456303). For instance plays a role in defending against oxidative damage induced by excessive copper stress (PubMed:25243607). Not required for maintaining normal lifespan (PubMed:14996832).
messages: No defects in lifespan or egg laying capacity (PubMed:14996832). Abolishes ctl-1 enzymatic activity and reduces the global levels of catalase activity to 75% of the total catalase activity observed in wild-type animals (PubMed:14996832).
messages: Up-regulated in response to Cu(2+) (PubMed:25243607). Up-regulated in response to phoxim (an organophosphorus insecticide) and carbaryl (a carbamate insecticide) (PubMed:28456303).
messages: Was originally reported to play a role in determining adult lifespan. However, the paper was later retracted due to errors in the data.

6239:CELE R13D11.8
gene id: 6239:CELE_R13D11.8
uniprot id: O17013
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F31F6.4
gene id: 6239:CELE_F31F6.4
uniprot id: G5EGN5
uniprot id: Q8WQF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

6239:CELE B0523.5
gene id: 6239:CELE_B0523.5
uniprot id: P34268
names: Function
names: Similarity
messages: Belongs to the villin/gelsolin family.
messages: May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components.

6239:CELE C54D2.5
gene id: 6239:CELE_C54D2.5
uniprot id: G5EBS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

6239:CELE F54F2.1
gene id: 6239:CELE_F54F2.1
uniprot id: P34446
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the integrin alpha chain family.
messages: Expressed in body-wall muscle cells, distal tip cells, and vulval tissue.
messages: Heterodimer of an alpha and a beta subunit (Probable). Interacts with beta subunit pat-3 (Probable). Interacts with dep-1 (PubMed:28135265). Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).
messages: Membrane
messages: Required for muscle development probably through the regulation of the actin-myosin cytoskeleton (PubMed:8106547, PubMed:12915588). Component of an integrin containing attachment complex, which is required for muscle maintenance (PubMed:22253611). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52 (PubMed:16495308). Required for distal tip cell migration and dorsal pathfinding (PubMed:17606640). Required for egg-laying (PubMed:12915588). May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vulval development (PubMed:28135265). Probably within the alpha pat-2/beta pat-3 integrin receptor complex, plays a role in the negative regulation of let-23 signaling and vulval induction. This is probably partly by restricting the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).
messages: Severe paralysis at the 1-fold stage of embryonic development followed by an arrest in elongation at 2-fold stage (PubMed:8106547). Loss of myosin and actin organization in embryonic body wall muscles and loss of muscle cell polarization (PubMed:8106547). RNAi-mediated knockdown in post-hatching animals causes paralysis associated with severe disorganization of body wall muscle actin filaments and defects in egg-laying associated with embryonic hatching within the mother (the bag of worms phenotype) (PubMed:12915588). Few surviving adults, are uncoordinated with abnormal body size and shape and have defects in distal tip cells (DTC) migration resulting in abnormal gonad formation (PubMed:17606640). RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown in vulval precursor cells in a let-60 gain of function mutant background results in increased vulval induction and an adjacent primary fate (Apf) phenotype whereby secondary vulval precursor cells transform into primary-like vulval cells (PubMed:28135265).
messages: Up-regulated during L3 developmental stage in distal tip cells.

6239:CELE K11D9.2
gene id: 6239:CELE_K11D9.2
uniprot id: A8WI68
uniprot id: G5EEK8
uniprot id: Q9XU13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

6239:CELE Y71H2AM.19
gene id: 6239:CELE_Y71H2AM.19
uniprot id: D0PV95
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Binds RNA as a monomer at low laf-1 concentrations and as a dimer at high laf-1 concentrations.
messages: Cell membrane
messages: Cytoplasm
messages: Cytoplasmic granule
messages: Embryonic lethal or lethal at the first larval stage of development (PubMed:9043090). Embryos exhibit severe morphological defects (PubMed:9043090). RNAi-mediated knockdown results in embryonic lethality in 88% of animals (PubMed:19361491, PubMed:26015579). Knockdown also results in disrupted P granule organization and assembly in the early embryo (PubMed:26015579). Reduced survival in response to heat and oxidative stress (PubMed:24844228). Double RNAi knockdown with vbh-1 results in a high number of female offspring (PubMed:19361491).
messages: Expressed at all developmental stages. Highly expressed in embryos with levels decreasing during larval development and increasing as animals reach adulthood.
messages: Expressed in the germline and soma of young adult hermaphrodites.
messages: Inflammasome
messages: Multifunctional ATP-dependent RNA helicase (PubMed:27546789). Plays a role in RNA remodeling, but is not required for RNA unwinding (PubMed:27546789). Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA (PubMed:26015579, PubMed:27546789). This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing (PubMed:27546789). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in the regulation of transcription and translation initiation. Involved in innate immunity (By similarity). Involved in both stress and inflammatory responses (By similarity). Promotes liquid-liquid phase separation of P granules, which is a process important for intracellular organization and stress granule assembly (PubMed:26015579). Required for embryonic development (PubMed:19361491, PubMed:26015579). Plays a role in sexual cell fate determination by negatively regulating the translation of the sex determining protein tra-2 (PubMed:9043090, PubMed:9321409, PubMed:26015579). May play a protective role in the response to heat and oxidative stress (PubMed:24844228). May negatively regulate extrinsic apoptotic signaling pathway via death domain receptors. May be involved in mitotic chromosome segregation (By similarity).
messages: Nucleus
messages: Stress granule
messages: The N-terminal domain is required for the multimeric binding of laf-1 to RNA.
messages: lamellipodium

6239:CELE Y37D8A.15
gene id: 6239:CELE_Y37D8A.15
uniprot id: Q9XWV7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Defective forwards locomotion whereby sustained long foraging forwards movements are replaced with shortened forwards runs, more frequent pauses and reversals.
messages: Expressed in RID peptidergic neurons, and the sensory neurons ALA, PDE and PLN.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides (PubMed:16187307). KHEYLRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system (PubMed:16187307). Functions in RID peptidergic neurons to promote forward locomotory behavior (PubMed:27855782).
messages: Perikaryon
messages: Secreted
messages: axon

6239:CELE C43H8.1
gene id: 6239:CELE_C43H8.1
uniprot id: Q9TZN1
names: Function
names: Similarity
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (F16A11.2).

6239:CELE F29D10.4
gene id: 6239:CELE_F29D10.4
uniprot id: Q19901
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE T19D12.8
gene id: 6239:CELE_T19D12.8
uniprot id: Q22576
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F48G7.7
gene id: 6239:CELE_F48G7.7
uniprot id: O44586
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K03E5.2
gene id: 6239:CELE_K03E5.2
uniprot id: H2KZW0
uniprot id: H2KZW1
uniprot id: O61848
names: Similarity
messages: Belongs to the calponin family.

6239:CELE F53F8.1
gene id: 6239:CELE_F53F8.1
uniprot id: O62259
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Expressed in all developmental stages, increasing gradually from embryo to larval L3 stage, decreasing in L4 and stabilizing in adult stage.
messages: Expressed predominantly in intestine.
messages: Expression is repressed in response to high levels of dietary calcium.
messages: Lipid contents in the intestine increase by 44%, but increase is less in response to high levels of dietary calcium.
messages: Nucleus
messages: Probable transcription factor which regulates lipid metabolism.

6239:CELE Y24D9A.4
gene id: 6239:CELE_Y24D9A.4
uniprot id: Q966C6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Interacts with cmd-1 in the presence of Ca(2+).

6239:CELE T23B12.4
gene id: 6239:CELE_T23B12.4
uniprot id: O17003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

6239:CELE C29E4.3
gene id: 6239:CELE_C29E4.3
uniprot id: P34342
names: Function
names: Subcellular Location Annotation
messages: GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.
messages: Nucleus

6239:CELE Y113G7A.9
gene id: 6239:CELE_Y113G7A.9
uniprot id: G5EFS4
names: Activity Regulation
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the HIT family.
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) and tri-methylguanosine diphosphate (m3(2,2,7)GDP) to m(7)GMP and m3(2,2,7)GMP, respectively (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by dcs-1 to m7GMP. Binds to m7GpppG and strongly to m7GDP.
messages: Expressed in neurons in the ventral cord, the nerve ring and the pharynx.
messages: Expressed in the embryo during all developmental stages.
messages: Nucleus
messages: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping scavenger activity and acts as a competitive inhibitor in vitro.
messages: Up-regulated by heat schock.

6239:CELE ZK973.6
gene id: 6239:CELE_ZK973.6
uniprot id: Q9N4M4
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the nesprin family.
messages: First expressed in L1 larvae, and thereafter throughout adulthood.
messages: Interacts with F-actin via its N-terminal domain. Most likely interacts with unc-84; the interaction is probably required to recruit anc-1 to the nuclear envelope.
messages: Nuclear anchorage is lost resulting in free-floating nuclei that often cluster as the animal flexes. An increase in PVQ cell bodies mispositioned to the anterior is apparent between three-fold embryos and L1 larvae. Pharyngeal cells show defects including mispositioned organelles.
messages: Nucleus outer membrane
messages: Plays a central role in nuclear and mitochondrial anchoring (PubMed:12169658, PubMed:6889924, PubMed:10375507, PubMed:22298703). Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus (PubMed:15773756). Has a role in positioning of the cell body of the PVQ lumbar interneuron (PubMed:22298703).
messages: The KASH domain, which contains a potential transmembrane domain, is essential for the nuclear envelope targeting.
messages: The large coiled coil domains are composed of 6 nearly exact repeats of 903 residues. The last repeat is partial. These repeats are conserved in Hawai (CB4856), Australia (AB4) and Germany (RC301) strains. The length of the repeat may be maintained because of a selective advantage to keep the protein large and allow a single molecule to extent more than 0,5 micrometers.
messages: Ubiquitously expressed in all postembryonic cells.
messages: cytoskeleton

6239:CELE Y5H2B.2
gene id: 6239:CELE_Y5H2B.2
uniprot id: Q9N4Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: May interact with nuclear hormone receptor nhr-49.
messages: Nucleus
messages: Orphan nuclear receptor (PubMed:22511885). Involved in regulating fatty acid desaturase genes, acting in concert with nuclear hormone receptor nhr-49 (PubMed:22511885).

6239:CELE C16C10.1
gene id: 6239:CELE_C16C10.1
uniprot id: Q09461
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane

6239:CELE F35H8.5
gene id: 6239:CELE_F35H8.5
uniprot id: Q20084
names: Similarity
messages: Belongs to the RRM elav family.

6239:CELE Y62E10A.17
gene id: 6239:CELE_Y62E10A.17
uniprot id: G2HK15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AP-2 family.
messages: Binds DNA as a dimer.
messages: Cytoplasm
messages: Nucleus
messages: Sequence-specific DNA-binding protein that interacts with enhancer elements to regulate transcription of selected genes (By similarity). Required for neuroblast and epidermal morphogenesis, perhaps acting in cooperation with transcription factor aptf-4 (PubMed:27176626).

6239:CELE C33H5.7
gene id: 6239:CELE_C33H5.7
uniprot id: Q18403
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C31H5.6
gene id: 6239:CELE_C31H5.6
uniprot id: B3WFZ3
uniprot id: B3WFZ4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE C05C10.4
gene id: 6239:CELE_C05C10.4
uniprot id: Q09451
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

6239:CELE C42C1.1
gene id: 6239:CELE_C42C1.1
uniprot id: A3QMB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F53G12.6
gene id: 6239:CELE_F53G12.6
uniprot id: O01798
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Expression is restricted to male germline.
messages: Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.

6239:CELE F45H11.2
gene id: 6239:CELE_F45H11.2
uniprot id: Q93725
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family.
messages: Cleavage of precursor form is necessary for function.
messages: Cytoplasm
messages: Expressed throughout development.
messages: Interacts with dcn-1 (PubMed:15988528). Covalently attached to cullins (PubMed:12781129). May interact with atx-3 (PubMed:17935801).
messages: Nucleus
messages: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
messages: Worms either arrest during embryonic development, or show vulval eversion at the L4 stage and burst at the vulva during the L4-to-adult molt. Those who survive to the adult stage display severe defects in terminal differentiation of seam cells, vulva and male tail.

6239:CELE Y54F10BM.1
gene id: 6239:CELE_Y54F10BM.1
uniprot id: Q95XK4
names: Similarity
messages: Belongs to the PP2C family.

6239:CELE C49C3.5
gene id: 6239:CELE_C49C3.5
uniprot id: Q9XUG3
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y92H12BL.5
gene id: 6239:CELE_Y92H12BL.5
uniprot id: Q95XC4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

6239:CELE T13B5.1
gene id: 6239:CELE_T13B5.1
uniprot id: G5EBN9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the sodium:neurotransmitter symporter (SNF) family.
messages: Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space. Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine.
messages: Cell membrane
messages: Highly expressed in the head, the excretory canal, tail hypodermal cells, epidermis and vulval epithelial cells. Expressed in the excretory canal-associated neuron and in some non-amphidial sensory neurons in the head (at protein level).
messages: Mutant worms are morphologically similar to the wild-type but exhibit mild swimming defects and are lethargic when crawling on a food-free environment with their movement being interrupted by frequent pauses. Worms paralyze in the presence of exogenous betaine. Simultaneous knockdown of snf-3 and egl-8 results in uncoordinated, hypercontracted and paralyzed animals.

6239:CELE F56A6.4
gene id: 6239:CELE_F56A6.4
uniprot id: Q9GZG5
uniprot id: V6CJ54
uniprot id: V6CLH9
uniprot id: V6CLM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

6239:CELE Y46G5A.24
gene id: 6239:CELE_Y46G5A.24
uniprot id: Q9U2E4
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

6239:CELE W07G1.2
gene id: 6239:CELE_W07G1.2
uniprot id: Q9XUK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE F31E8.2
gene id: 6239:CELE_F31E8.2
uniprot id: P34693
uniprot id: Q95QH7
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: Localized to regions known to be rich in synapses and appears to be associated with synaptic vesicles. Also found in some non-neuronal secretory structures.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death (PubMed:22157748).
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: Synapse
messages: Worms exhibit severe behavioral abnormalities that are characteristic of deficiencies in synaptic function, including severe locomotion, feeding, and defecation defects (PubMed:8391930). Increased survival in response to hypoxia induced by sodium azide (PubMed:22157748). Reduces the formation of neuron cell corpses in a hyperactive mec-4 or deg-3 mutant background (PubMed:22157748).
messages: synaptic vesicle membrane

6239:CELE R05D3.2
gene id: 6239:CELE_R05D3.2
uniprot id: P34535
names: Similarity
messages: Belongs to the LIMR family.

6239:CELE F19F10.5
gene id: 6239:CELE_F19F10.5
uniprot id: O01519
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Probable transcription factor (By similarity). Involved in responses to oxidative stress (PubMed:27514077).
messages: Up-regulated by salicylamine.

6239:CELE F15B10.2
gene id: 6239:CELE_F15B10.2
uniprot id: G5EDI8
names: Similarity
messages: Belongs to the helicase family. RLR subfamily.

6239:CELE D2096.4
gene id: 6239:CELE_D2096.4
uniprot id: G5EF65
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

6239:CELE T06D8.7
gene id: 6239:CELE_T06D8.7
uniprot id: Q22252
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FUN14 family.
messages: Broadly expressed in somatic tissues (PubMed:31233739). Expressed in the hermaphrodite spermatheca and male gonad (PubMed:31233739). Expressed in spermatids, but not expressed in oocytes (PubMed:31233739).
messages: Mitochondrion outer membrane
messages: Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage.

6239:CELE ZK512.6
gene id: 6239:CELE_ZK512.6
uniprot id: P34644
uniprot id: S6DQ91
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
messages: Cell membrane
messages: Defective preference between different food odors (PubMed:25009271). Abnormal repetitive turning behavior during male mating (PubMed:17611271).
messages: Expressed in neurons of the pharynx and the extrapharyngeal nervous system. Highly expressed in male PHC sensory neurons (PubMed:28065609).
messages: Highly expressed in male PHC sensory neurons from the late L4 larval stage/young adult stage.
messages: Membrane
messages: Required for glutamatergic synaptic transmission (PubMed:10818169, PubMed:14762140, PubMed:14981253, PubMed:15371514, PubMed:9526004, PubMed:9870947). In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons (PubMed:25009271). Negatively regulates the turning step of male mating behavior (PubMed:17611271).
messages: Synapse

6239:CELE T10D4.13
gene id: 6239:CELE_T10D4.13
uniprot id: Q71UE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE C14C6.5
gene id: 6239:CELE_C14C6.5
uniprot id: A0A0K3AXM4
uniprot id: O44667
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE M03A1.1
gene id: 6239:CELE_M03A1.1
uniprot id: O61460
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
messages: Cell membrane
messages: Dephosphorylated by daf-18.
messages: During ventral enclosure of the epidermis, expression is seen in clusters of presumptive head neuronal cells and several cells in the tail region. Early larvae show expression in the nerve ring and ventral nerve cord. Strong expression is also seen in the procorpus and terminal bulb of the pharynx. Expression in the nervous system is seen through to adulthood (PubMed:9506518, PubMed:19853560). Expressed in Z2/Z3 germline precursor cells and in oocytes (at protein level). Expressed in the vulva and in the spermatheca with accumulation in the apical regions of the organ (PubMed:25529479). Expressed in oocytes and sheath cells (PubMed:12533508).
messages: Expressed in larval stage L4.
messages: Interacts (via kinase domain) with daf-18 (via C-terminus); the interaction is independent of vab-1 kinase activity.
messages: RNAi-mediated knockdown results in impaired inhibition of oocyte maturation and ovulation in the presence of reduced numbers of self-derived sperm (PubMed:12533508). As a result, hermaphrodites lay increased numbers of unfertilized oocytes (PubMed:12533508). Reduced sheath cell contraction rate in somatic cells (PubMed:12533508).
messages: Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm-sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization (PubMed:12533508). Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs (PubMed:12533508, PubMed:19853560). Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells (PubMed:12533508). Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation (PubMed:19853560). By inactivating daf-18, regulates positively insulin-like daf-2 signaling cascade (PubMed:9506518). Involved in interactions between neuronal substrate cells and a migrating epithelial sheet in head epidermis morphogenesis (PubMed:9506518). Also required for cell movements following gastrulation and during ventral closure of the epidermis (PubMed:9506518). Might play a role in spermatheca morphogenesis (PubMed:25529479). Involved in axon guidance of SDQL neurons during neurogenesis (PubMed:26903502).

6239:CELE R07H5.3
gene id: 6239:CELE_R07H5.3
uniprot id: B2MZC3
uniprot id: Q93931
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

6239:CELE F25G6.4
gene id: 6239:CELE_F25G6.4
uniprot id: O16926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE C27F2.5
gene id: 6239:CELE_C27F2.5
uniprot id: Q18258
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

6239:CELE ZK6.2
gene id: 6239:CELE_ZK6.2
uniprot id: O61872
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T13F3.3
gene id: 6239:CELE_T13F3.3
uniprot id: O18087
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor (Probable). May play a role in modulation of lifespan and immunity (PubMed:29748542).
messages: Transcription up-regulated in response to intestinal colonization by probiotic Lactobacillus fermentum strain JDFM216.

6239:CELE Y55B1AL.2
gene id: 6239:CELE_Y55B1AL.2
uniprot id: Q9N390
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxin-induced degradation of the protein causes no obvious phenotype in germ cells and early embryos.
messages: Belongs to the TFB5 family.
messages: Chromosome
messages: Component of the 7-subunit TFIIH core complex.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and in RNA transcription by RNA polymerase II (By similarity). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment (By similarity). In transcription, TFIIH has an essential role in transcription initiation (By similarity). When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape (By similarity). Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell (PubMed:34824371). Required for efficient binding of TFIIH to damaged DNA (PubMed:34824371). Dispensable for normal development, but required when transcription is challenged (PubMed:34824371).
messages: Nucleus

6239:CELE F39H11.2
gene id: 6239:CELE_F39H11.2
uniprot id: B2D6P4
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: May be a general transcription factor (PubMed:11030350, PubMed:11030349). Plays an essential role for RNA polymerase II/ama-1 transcription in early embryos whereby it activates a subset of RNA polymerase II promoters and facilitates the reestablishment of transcription after mitosis (PubMed:14726532).
messages: Nucleus
messages: RNAi-mediated knockdown causes early embryonic defects, including premature cell division of the Ea and Ep blastomeres, a failure to undergo gastrulation, and embryonic arrest (PubMed:11030350, PubMed:11030349). Knockdown causes severe loss of polymerase II large subunit ama-1 phosphorylation (PubMed:11030350, PubMed:11030349). Knockdown also causes a reduction in expression levels of several embryonic genes (PubMed:11030350, PubMed:11030349, PubMed:14726532).
messages: Widely expressed throughout embryogenesis, starting at the two-cell stage and probably expressed both maternally and zygotically (at protein level).

6239:CELE C03G6.10
gene id: 6239:CELE_C03G6.10
uniprot id: O01446
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZC247.3
gene id: 6239:CELE_ZC247.3
uniprot id: P20154
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in ADL, AVJL, AIZL, RICL, RIF and AVG neurons.
messages: Nucleus
messages: Probable transcription factor which is required for asymmetric division of vulval blast cells (PubMed:1970421, PubMed:15466489). Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons (PubMed:19561603). Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons (PubMed:29672507). Plays a role in the differentiation of the ADL sensory neurons (PubMed:29672507).

6239:CELE F10E7.4
gene id: 6239:CELE_F10E7.4
uniprot id: Q19305
names: Subcellular Location Annotation
messages: extracellular matrix

6239:CELE C25A1.2
gene id: 6239:CELE_C25A1.2
uniprot id: O17593
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE D2063.1
gene id: 6239:CELE_D2063.1
uniprot id: Q9UAT1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

6239:CELE F11G11.12
gene id: 6239:CELE_F11G11.12
uniprot id: P91250
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F44F1.3
gene id: 6239:CELE_F44F1.3
uniprot id: O02260
names: Similarity
messages: Belongs to the peptidase C2 family.

6239:CELE AH6.7
gene id: 6239:CELE_AH6.7
uniprot id: Q09205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C43F9.9
gene id: 6239:CELE_C43F9.9
uniprot id: Q7YTP9
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F43G9.13
gene id: 6239:CELE_F43G9.13
uniprot id: Q95QG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

6239:CELE H03A11.2
gene id: 6239:CELE_H03A11.2
uniprot id: G5EFE3
names: Similarity
messages: Belongs to the FAM154 family.

6239:CELE T19A6.2
gene id: 6239:CELE_T19A6.2
uniprot id: Q9XXN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

6239:CELE C34E10.7
gene id: 6239:CELE_C34E10.7
uniprot id: P46581
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding (PubMed:10976055). Involved in regulating glial specification (PubMed:32665354).
messages: Defects in axonal morphology and synaptic connectivity of the ventral cord motor neurons.
messages: Expressed at the 14 cell embryo stage.
messages: Expressed in neuroblasts of the AB lineage. More specifically in precursors of the embryonic ventral cord motor neurons. Expressed to a lesser degree in the EMS lineage which generates mostly endoderm and mesoderm tissues.
messages: Nucleus

6239:CELE T03G11.3
gene id: 6239:CELE_T03G11.3
uniprot id: Q22122
names: Similarity
messages: Belongs to the ZC2HC1 family.

6239:CELE T01E8.6
gene id: 6239:CELE_T01E8.6
uniprot id: P49391
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). Interacts with LIAT1 (By similarity).
messages: Mitochondrion

6239:CELE C52E4.3
gene id: 6239:CELE_C52E4.3
uniprot id: Q18786
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
messages: cytosol

6239:CELE F59A3.4
gene id: 6239:CELE_F59A3.4
uniprot id: P91354
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F08F8.7
gene id: 6239:CELE_F08F8.7
uniprot id: Q95ZW2
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

6239:CELE F48E3.1
gene id: 6239:CELE_F48E3.1
uniprot id: G5EBG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

6239:CELE F42G9.9
gene id: 6239:CELE_F42G9.9
uniprot id: O02592
names: Subcellular Location Annotation
messages: cytoskeleton

6239:CELE F48E8.6
gene id: 6239:CELE_F48E8.6
uniprot id: Q09568
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cleaved by caspase ced-3 in vitro.
messages: Cytoplasm
messages: P-body
messages: RNAi-mediated knockdown in a ced-3 and ain-1 double mutant background reduces the percentage of animals with developmental defects including production of ectopic seam cells.

6239:CELE R06A4.8
gene id: 6239:CELE_R06A4.8
uniprot id: O62334
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

6239:CELE F57B10.11
gene id: 6239:CELE_F57B10.11
uniprot id: O44739
names: Domain
names: Function
names: Subunit
messages: Homodimer or homotetramer.
messages: May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.
messages: The BAG domain probably mediates direct interaction with HSP70.

6239:CELE W09G3.2
gene id: 6239:CELE_W09G3.2
uniprot id: O18188
names: Subcellular Location Annotation
messages: Nucleus matrix

6239:CELE F07C4.11
gene id: 6239:CELE_F07C4.11
uniprot id: P91216
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C31B8.7
gene id: 6239:CELE_C31B8.7
uniprot id: O16900
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE C44C3.1
gene id: 6239:CELE_C44C3.1
uniprot id: P91160
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE B0222.3
gene id: 6239:CELE_B0222.3
uniprot id: Q17455
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

6239:CELE C27A2.6
gene id: 6239:CELE_C27A2.6
uniprot id: Q18239
names: Similarity
messages: Belongs to the DSH family.

6239:CELE F52D10.1
gene id: 6239:CELE_F52D10.1
uniprot id: G5EGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

6239:CELE C12D8.5
gene id: 6239:CELE_C12D8.5
uniprot id: Q17938
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cholesterol 7-desaturase family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Catalyzes the production of 7-dehydrocholesterol (7-DHC or cholesta-5,7-dien-3beta-ol) by inserting a double bond (desaturating) at the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)-dafachronic acid (one of the principal steroid hormones in nematodes). Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth.
messages: Expressed in intestine at all postembryonic stages, including dauer. Expression is reduced in daf-2 mutants.
messages: Membrane

6239:CELE B0304.1
gene id: 6239:CELE_B0304.1
uniprot id: P22980
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Body wall muscle cells; in clonal muscle precursors, in a set of early embryonic blastomeres (the ms-granddaughters), and in six glial-like cells called GLRS.
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Involved in myogenesis, in cooperation with transcription factors unc-120 and hnd-1 (PubMed:2175254, PubMed:15892873, PubMed:17142668). Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2 (PubMed:21307099).
messages: Nucleus
messages: RNAi-mediated knockdown results in a low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage; increases in frequency significantly on an hnd-1 or unc-120 mutant background (PubMed:15892873). Many embryos that survive to hatch become uncoordinated, dumpy larvae (PubMed:15892873). Double RNAi-mediated knockdown with sem-2 results in no sex myoblast production (PubMed:21307099).

6239:CELE C42D8.4
gene id: 6239:CELE_C42D8.4
uniprot id: I7KSB9
uniprot id: Q18579
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Expressed in a subset of head neurons, including the BAG sensory neurons, the AWA amphid neurons and the ASG sensory neurons.
messages: Expressed throughout development and in adult animals (PubMed:21954162). First expressed in the embryonic BAG neurons (PubMed:30890567).
messages: Lack of CO(2) avoidance behavior (PubMed:21954162, PubMed:22479504). Down-regulation of genes required for BAG neuron differentiation and function (PubMed:21954162, PubMed:22479504). Reduction in exploratory behavior and an increase of animals in the quiescent state (PubMed:28193866). Unable to sense downsteps of O(2) (PubMed:28193866). Increased intestinal fat storage (PubMed:28193866).
messages: Nucleus
messages: Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons (PubMed:21954162, PubMed:22479504, PubMed:30890567). The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels (PubMed:21954162, PubMed:22479504, PubMed:28193866). Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons (PubMed:21954162). Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons (PubMed:22479504). May mediate transcriptional activation by binding to the motif 5'-ACTTCCG-3' (PubMed:22479504, PubMed:30890567). Acts in the BAG and ASG neurons to regulate intestinal fat levels and to promote exploratory behavior, possibly by regulating neuropeptidergic signaling (PubMed:28193866).

6239:CELE T28A11.11
gene id: 6239:CELE_T28A11.11
uniprot id: P91505
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Homodimer.

6239:CELE C05G5.5
gene id: 6239:CELE_C05G5.5
uniprot id: Q17678
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease.

6239:CELE Y67D2.1
gene id: 6239:CELE_Y67D2.1
uniprot id: Q9BKQ5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Expressed in several neurons including head neurons, motor neurons located in the ventral nerve cord, HSN and CAN neurons, and tail neurons, and in muscles such as body-wall, pharyngeal, intestinal and anal sphincter (PubMed:19090809). Also expressed in seam cells, the hypodermis and the intestine (PubMed:19090809).
messages: May interact with rab-5, rab-7 and rab-11 (PubMed:19090809). Does not interact with rab-3, rab-27 and rab-10 (PubMed:19090809).
messages: RNAi-mediated knockdown results in mild defecation defects (PubMed:19090809). RNAi-mediated knockdown increases the levels of unprenylated rab-27 (PubMed:19090809). RNAi-mediated knockdown disrupts the localization of rab-5 and rab-7 (PubMed:19090809).
messages: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex (By similarity). Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B and remains bound to it after the geranylgeranyl transfer reaction (By similarity). The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane (By similarity). Plays a role in neurotransmitter release from presynaptic terminals at neuromuscular junctions (PubMed:19090809). Positively regulates the function of rab-27 in synaptic transmission most likely through mediating rab-27 prenylation (PubMed:19090809).

6239:CELE K07C6.5
gene id: 6239:CELE_K07C6.5
uniprot id: O44649
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C03G6.5
gene id: 6239:CELE_C03G6.5
uniprot id: O01454
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0376 family.
messages: Secreted

6239:CELE Y116A8C.5
gene id: 6239:CELE_Y116A8C.5
uniprot id: Q9U2T0
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE F26G1.10
gene id: 6239:CELE_F26G1.10
uniprot id: Q2V4U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F42A9.5
gene id: 6239:CELE_F42A9.5
uniprot id: Q27499
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE Y51H4A.17
gene id: 6239:CELE_Y51H4A.17
uniprot id: Q9NAD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transcription factor STAT family.
messages: Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor.
messages: Cytoplasm
messages: Expressed in adult and larval pharynx, head ganglia, tail ganglia, ventral nerve cord and body muscles.
messages: Forms a homodimer or a heterodimer with a related family member.
messages: Nucleus

6239:CELE C18E3.7
gene id: 6239:CELE_C18E3.7
uniprot id: Q86NJ8
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE Y23H5B.6
gene id: 6239:CELE_Y23H5B.6
uniprot id: Q9N478
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE Y25C1A.9
gene id: 6239:CELE_Y25C1A.9
uniprot id: Q9TYL8
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE T13H10.1
gene id: 6239:CELE_T13H10.1
uniprot id: G5EC46
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE C14A4.11
gene id: 6239:CELE_C14A4.11
uniprot id: Q17958
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are sterile and develop slowly. Excretory canals are approximately 45% shorter and are characterized by a discontinuous and wider lumen, the presence of cysts and an increased number of canalicular vesicles which are swollen. These defects start during the L3 larval stage and become more severe when reaching adulthood. In addition, cdc-42 expression levels and activity are reduced along the excretory canal length. Animals have also a reduced distribution of Golgi and ER components along the excretory canals.
messages: Apical cell membrane
messages: Belongs to the PDCD10 family.
messages: Cytoplasm
messages: Expressed in pharynx, intestine, germline, vulva and excretory canals.
messages: Interacts with gck-1.
messages: Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility.

6239:CELE B0546.4
gene id: 6239:CELE_B0546.4
uniprot id: O44440
names: Similarity
messages: Belongs to the yippee family.

6239:CELE C09B8.1
gene id: 6239:CELE_C09B8.1
uniprot id: Q17848
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

6239:CELE ZK524.3
gene id: 6239:CELE_ZK524.3
uniprot id: B3WFV4
uniprot id: Q23511
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE F40E10.4
gene id: 6239:CELE_F40E10.4
uniprot id: G5EFX6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development.
messages: Interacts with eva-1.
messages: Secreted

6239:CELE R05H5.4
gene id: 6239:CELE_R05H5.4
uniprot id: Q21764
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F56A12.1
gene id: 6239:CELE_F56A12.1
uniprot id: O17894
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Expressed in muscles and neurons from embryogenesis to adulthood (PubMed:15282156, PubMed:27855782). First expressed post-fertilization, then accumulates in anterior cells of the embryo that give rise to neuronal and mesodermal tissues and body wall muscle cells, where expression persists and increases (PubMed:15282156). Also expressed in posterior nuclei post-fertilization (PubMed:15282156). At the 2-fold stage of embryogenesis, expression is restricted to fewer cells (PubMed:15282156).
messages: Nucleus
messages: Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons (PubMed:2361334, PubMed:15282156). Specifically, plays a role in the terminal differentiation of RID peptidergic neurons (PubMed:27855782). Also required for CAN neuron axon guidance (PubMed:15282156).
messages: RNAi-mediated knockdown results in 60% larval lethality (PubMed:15282156). Surviving animals display uncoordinated locomotion, withered tail morphology, and defects in both CAN neuronal cell migration and axon guidance (PubMed:15282156).

6239:CELE F59E11.2
gene id: 6239:CELE_F59E11.2
uniprot id: O16764
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE C24G7.1
gene id: 6239:CELE_C24G7.1
uniprot id: P91103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE K09B3.1
gene id: 6239:CELE_K09B3.1
uniprot id: Q94268
uniprot id: U4PQR0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F10E7.5
gene id: 6239:CELE_F10E7.5
uniprot id: Q19302
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

6239:CELE T25E12.4
gene id: 6239:CELE_T25E12.4
uniprot id: O45818
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domain 1 binds phorbol ester with low affinity. Phorbol-ester/DAG-type domain 2 binds phorbol ester with high affinity and targets the kinase to the cell periphery, enabling phosphorylation and activation by colocalized tpa-1. Both domains 1 and 2 appear to bind DAG with equal affinity so may contribute equally to translocation and activation.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor.
messages: Cytoplasm
messages: Expressed in the late embryo, all larval stages, and adult in the intestine and in cells positioned near the posterior bulb of the pharynx.
messages: Increase in adult life span. Increased levels of daf-16 translocate into the nucleus in response to heat stress. Hypersensitive to killing by bacteria.
messages: Membrane
messages: Phosphorylation on Ser-925 by tpa-1 is the dominant regulator of catalysis, phosphorylation on Ser-929 by tpa-1 has a lesser effect. Prolonged phosphorylation results in ubiquitination and degradation.

6239:CELE F26H11.2
gene id: 6239:CELE_F26H11.2
uniprot id: Q6BER5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPTF family.
messages: Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.
messages: Nucleus
messages: Part of a nucleosome remodeling factor-like (NURF-like) complex containing nurf-1 and isw-1.

6239:CELE T20D4.1
gene id: 6239:CELE_T20D4.1
uniprot id: P91475
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F11C3.3
gene id: 6239:CELE_F11C3.3
uniprot id: P02566
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
messages: MHC A and MHC B are found exclusively in the body wall muscle. They co-assemble into body wall thick filament.
messages: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Forms a complex composed of chaperone unc-45, unc-54 and ubiquitin-protein ligase ufd-2; promotes poly-ubiquitination of unfolded unc-54 (PubMed:29396393). Within the complex interacts with unc-45 (via UCS domain) and ufd-2 (PubMed:29396393). Interacts with itr-1 (via c-terminal coiled coil domain) (PubMed:12062062).
messages: Required for muscle contraction.
messages: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
messages: There are four different myosin heavy chains in C.elegans.
messages: Unfolded unc-54 is poly-ubiquitinated by ufd-2.
messages: Viable, but paralyzed. Double knockout with madd-3 results in lethality. Triple knockout with madd-3, and either cebp-1, dlk-1, mak-2, pmk-3 or sek-3 results in paralysis (as in the unc-54 single knockout), and suppresses the lethality phenotype in the double madd-3 and unc-54 mutant.
messages: myofibril

6239:CELE C03E10.4
gene id: 6239:CELE_C03E10.4
uniprot id: O17560
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE C14C6.8
gene id: 6239:CELE_C14C6.8
uniprot id: O44672
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE F09B12.6
gene id: 6239:CELE_F09B12.6
uniprot id: Q9NLA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Membrane
messages: Present in the intestinal cells from comma-stage embryos through the adult stage, although the intestinal expression is weaker after the L1 stage. Accumulates at the cell membrane of intestinal cells, especially the lateral membrane intervening the intestinal cells. Also detected in the muscles of the pharyngeal isthmus from the 3-fold embryonic stage, and in a pair of head neurons, which correspond to the AUA neurons, from the late L1 stage (at protein level).
messages: Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms.

6239:CELE C01G8.9
gene id: 6239:CELE_C01G8.9
uniprot id: X5M5M2
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K09A9.3
gene id: 6239:CELE_K09A9.3
uniprot id: Q93871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

6239:CELE F44G3.6
gene id: 6239:CELE_F44G3.6
uniprot id: G5EE67
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE C13C12.2
gene id: 6239:CELE_C13C12.2
uniprot id: Q17944
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in early developing glial cells of the embryo and accumulates between the embryo and the eggshell.
messages: Expressed in sheath and socket glial cells in both the amphid and phasmid ciliated sensory neurons (at protein level).
messages: Interacts with daf-6.
messages: Required for the localization of daf-6 to the socket glial channel and the sheath lumen (PubMed:34115759). In association with daf-6, plays a role in dendrite extension and ciliogenesis to ensure the formation of glial channels in amphid and phasmid ciliated sensory neurons (PubMed:34115759).
messages: Secreted

6239:CELE T14B4.9
gene id: 6239:CELE_T14B4.9
uniprot id: Q22481
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F52B5.1
gene id: 6239:CELE_F52B5.1
uniprot id: G5EDF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

6239:CELE F29G9.3
gene id: 6239:CELE_F29G9.3
uniprot id: O16369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Golgi apparatus
messages: clathrin-coated pit

6239:CELE C34H3.2
gene id: 6239:CELE_C34H3.2
uniprot id: Q9N5X6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Odd C2H2-type zinc-finger protein family.
messages: Expressed in the intestine from embryogenesis to adulthood. Highly expressed in the most anterior and posterior parts of the intestine in hatched larva. Also expressed in cells outside of the intestine near the anus in hatched larva.
messages: May function as transcription regulator (Probable). Required for morphogenesis and function of the digestive tract.
messages: Nucleus
messages: RNAi-mediated knockdown results in defects in feeding, and failed growth and development eventually leading to lethality at the late L1 to L2 stage of larval development. Morphological defects in the digestive tract, such as enlarged pharyngeal intestinal valve lumen, leading to functional defects including accumulation of ingested bacteria in the lumen of the posterior intestine and defective elimination from the anterior lumen of the intestine.

6239:CELE Y94H6A.1
gene id: 6239:CELE_Y94H6A.1
uniprot id: Q9N2W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F55B12.1
gene id: 6239:CELE_F55B12.1
uniprot id: Q9NLC2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the NK-2 homeobox family.
messages: Expressed in the 8 vulval muscles, 8-10 ventral neurons in the head and in the most posterior pharyngeal muscle cell, m8 (PubMed:9425137). Expressed in SIA, SIB and SMB sublateral motor neurons, and in muscles of the pharynx and vulva (PubMed:28244369).
messages: First expressed in the m8 pharyngeal muscle cell and in ventral head neurons in embryos 400 minutes after the first cell cleavage.
messages: Normal growth, coordination, egg-laying, mating, chemotaxis, pharyngeal pumping and VC neuron synapses as in wild-type animals (PubMed:9425137). Abnormal sleep behavior with mutant larvae displaying a reduced, if not absent, type of turning behavior called 'flipping' (PubMed:28244369). Irregular formation and extension of sublateral motor neuron processes (PubMed:28244369).
messages: Nucleus
messages: Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.

6239:CELE Y54E10BR.1
gene id: 6239:CELE_Y54E10BR.1
uniprot id: G4SNP0
uniprot id: Q9N3C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE Y41E3.4
gene id: 6239:CELE_Y41E3.4
uniprot id: D3YT95
uniprot id: D3YT96
uniprot id: O62431
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6239:CELE Y57A10A.28
gene id: 6239:CELE_Y57A10A.28
uniprot id: Q9NA73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM38 family.
messages: Endoplasmic reticulum membrane
messages: Homotrimer; trimerization probably requires binding to phosphatidylinositol 4,5-bisphosphate (PIP2).
messages: Potassium channel that mediates transmembrane potassium transport (By similarity). Might be required for maintenance of rapid intracellular calcium release (By similarity). May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27698420).

6239:CELE ZC410.4
gene id: 6239:CELE_ZC410.4
uniprot id: Q23297
uniprot id: Q7JM20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE Y59A8A.1
gene id: 6239:CELE_Y59A8A.1
uniprot id: Q9GS00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN1 family.
messages: Component of the CSN complex, probably composed of csn-1, csn-2, csn-3, csn-4, csn-5, csn-6 and csn-7. Within the complex it probably interacts directly with csn-2, csn-4 and csn-5. May interact with itself. Interacts with rbx-1.
messages: Cytoplasm
messages: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mitosis transition via deneddylation of cul-3.
messages: Nucleus

6239:CELE VC5.5
gene id: 6239:CELE_VC5.5
uniprot id: Q2V069
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T09H2.1
gene id: 6239:CELE_T09H2.1
uniprot id: O61935
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE R08D7.3
gene id: 6239:CELE_R08D7.3
uniprot id: P30642
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

6239:CELE Y59A8B.7
gene id: 6239:CELE_Y59A8B.7
uniprot id: Q9GRZ1
names: Similarity
messages: Belongs to the MAPRE family.

6239:CELE D1053.1
gene id: 6239:CELE_D1053.1
uniprot id: Q18938
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily. Zeta family.
messages: Cytoplasm

6239:CELE Y105E8B.8
gene id: 6239:CELE_Y105E8B.8
uniprot id: V6CLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

6239:CELE B0252.2
gene id: 6239:CELE_B0252.2
uniprot id: Q10916
names: Cofactor
names: Developmental Stage
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Does not require zinc ions as a cofactor.
messages: Preferentially expressed in embryos, lower expression in later development.
messages: Secreted
messages: Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH. Displays its enzymatic activity when secreted. May play distinct roles in signaling.
messages: There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinases have been found in worms.

6239:CELE T05G11.7
gene id: 6239:CELE_T05G11.7
uniprot id: G5EBL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T06H11.4
gene id: 6239:CELE_T06H11.4
uniprot id: G5EGH2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

6239:CELE F57H12.1
gene id: 6239:CELE_F57H12.1
uniprot id: G5EFK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

6239:CELE W01D2.1
gene id: 6239:CELE_W01D2.1
uniprot id: O62388
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

6239:CELE T27A3.6
gene id: 6239:CELE_T27A3.6
uniprot id: P91500
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

6239:CELE T23F11.3
gene id: 6239:CELE_T23F11.3
uniprot id: Q22695
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Accumulation of presynaptic components in the dendrite of DA motor neurons (PubMed:20510931). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).
messages: Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1 (PubMed:17671168). In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport (PubMed:20510931). Regulates the polarized distribution of dense-core vesicles in DB motor neurons (PubMed:22699897). May regulate these processes in association with cdk-5 (PubMed:17671168, PubMed:20510931). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cytoplasm
messages: Expressed in all classes of neurons in the ventral cord.
messages: Heterodimer composed of a catalytic subunit cdk-5 and a regulatory subunit cdka-1. Interaction with cdka-1 is required for cdk-5 activation.
messages: axon
messages: dendrite

6239:CELE T06C12.14
gene id: 6239:CELE_T06C12.14
uniprot id: O18039
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE B0495.10
gene id: 6239:CELE_B0495.10
uniprot id: Q09219
names: Similarity
messages: Belongs to the copine family.

6239:CELE F13D12.6
gene id: 6239:CELE_F13D12.6
uniprot id: P52715
names: Similarity
messages: Belongs to the peptidase S10 family.

6239:CELE T15H9.6
gene id: 6239:CELE_T15H9.6
uniprot id: Q09995
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

6239:CELE F23F12.10
gene id: 6239:CELE_F23F12.10
uniprot id: P46506
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE C35A5.2
gene id: 6239:CELE_C35A5.2
uniprot id: Q18470
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R02F2.1
gene id: 6239:CELE_R02F2.1
uniprot id: H2KZJ2
uniprot id: H2KZJ3
uniprot id: Q8IFZ8
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE C25E10.12
gene id: 6239:CELE_C25E10.12
uniprot id: Q18161
names: Similarity
messages: Belongs to the UPF0046 family.

6239:CELE ZC504.5
gene id: 6239:CELE_ZC504.5
uniprot id: O18280
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.
messages: Chemoreceptor involved in light-induced avoidance behavior (PubMed:25640076). Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076). Involved in circadian rhythms, probably by acting as a light sensor (PubMed:27849618). In contrast to lite-1, does not act as a photoreceptor (PubMed:27863243).
messages: Expressed in I2 pharyngeal neurons.
messages: Membrane

6239:CELE C06A8.6
gene id: 6239:CELE_C06A8.6
uniprot id: Q17692
names: Similarity
messages: Belongs to the SDS22 family.

6239:CELE C05B5.2
gene id: 6239:CELE_C05B5.2
uniprot id: P34290
names: Subcellular Location Annotation
messages: Membrane

6239:CELE ZK525.2
gene id: 6239:CELE_ZK525.2
uniprot id: O46024
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F39H11.3
gene id: 6239:CELE_F39H11.3
uniprot id: P90866
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE C25H3.5
gene id: 6239:CELE_C25H3.5
uniprot id: Q18184
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Secreted

6239:CELE F54A3.2
gene id: 6239:CELE_F54A3.2
uniprot id: Q9N4J7
names: Similarity
messages: Belongs to the TOG/XMAP215 family.

6239:CELE F44E2.10
gene id: 6239:CELE_F44E2.10
uniprot id: Q95QG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6239:CELE R07G3.5
gene id: 6239:CELE_R07G3.5
uniprot id: Q09422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity.
messages: Interacts with skn-1 isoforms a and c.
messages: Mitochondrion outer membrane

6239:CELE C02F5.8
gene id: 6239:CELE_C02F5.8
uniprot id: P34285
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6239:CELE F56B3.1
gene id: 6239:CELE_F56B3.1
uniprot id: O45114
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K02F2.2
gene id: 6239:CELE_K02F2.2
uniprot id: P27604
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

6239:CELE F42G8.10
gene id: 6239:CELE_F42G8.10
uniprot id: O44509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane

6239:CELE F53B6.1
gene id: 6239:CELE_F53B6.1
uniprot id: Q9XVM9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Embryonic lethal (PubMed:23028364). Mutants display dumpy and blistered cuticle phenotypes (PubMed:23028364). Blisters contain unidentified cellular material (PubMed:23028364, PubMed:25480962). Resistant to iodide toxicity (PubMed:25480962). RNAi-mediated knockdown results in the lethality of more than 95% of progeny at the larval stage (PubMed:15454573). Most larval arrest occurs at the L4 larval stage and is characterized by body swelling and abnormal epidermal morphology, which includes blistering of the cuticle (PubMed:15454573, PubMed:25480962). The few animals that develop into adults have a distended body shape and/or epidermal blistering (PubMed:15454573). Abnormal cuticular and hypodermal morphology including splits in the cortical layer of the cuticle, abnormal gaps between the hypodermis and musculature and inconsistent thickness of the hypodermis (PubMed:15454573, PubMed:25480962). Impaired hypodermal membrane integrity and reduced fibrous organelles (PubMed:15454573).
messages: Expressed in cells along the anteroposterior axis from the 1.5-fold stage of embryogenesis until the 3-fold stage when expression decreases but increases in the body surface with prominent expression in the lateral hypodermal cells (PubMed:23028364, PubMed:15454573). Expressed in the pharynx and body wall from the larval stage to adulthood.
messages: Expressed in the body wall (hyp7 hypodermal syncitium), pharynx and vulva. Expressed in a punctate pattern along the thick region of the hypodermis.
messages: Interacts with doxa-1 and bli-3.
messages: Membrane
messages: Plays a role in cuticle biogenesis (PubMed:15454573, PubMed:23028364, PubMed:25480962). In complex with doxa-1 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix (PubMed:23028364).

6239:CELE F30B5.4
gene id: 6239:CELE_F30B5.4
uniprot id: Q19910
names: Similarity
messages: Belongs to the OKL38 family.

6239:CELE C27D9.2
gene id: 6239:CELE_C27D9.2
uniprot id: Q18256
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F58A3.4
gene id: 6239:CELE_F58A3.4
uniprot id: Q93806
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE C07E3.9
gene id: 6239:CELE_C07E3.9
uniprot id: Q17790
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

6239:CELE C55C2.2
gene id: 6239:CELE_C55C2.2
uniprot id: O01829
names: Subunit
names: Tissue Specificity
messages: Expressed at higher level in testis.
messages: Monomer.

6239:CELE C06E7.1
gene id: 6239:CELE_C06E7.1
uniprot id: P50305
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
messages: Protein expression is regulated by post-transcriptional regulation: under rich-diet conditions, mett-10 binds and methylates sams-3 mRNA, directly inhibiting splicing and protein production of S-adenosylmethionine synthase.

6239:CELE B0222.5
gene id: 6239:CELE_B0222.5
uniprot id: Q17457
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K07C11.9
gene id: 6239:CELE_K07C11.9
uniprot id: Q21270
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Required for normal Golgi function.

6239:CELE B0432.5
gene id: 6239:CELE_B0432.5
uniprot id: P90986
uniprot id: S6FN11
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: Expressed in dopaminergic cells. Expressed in neurons in the head and middle body of the hermaphrodite, and six neurons in the tail of the male.
messages: Inhibited by dopamine with an IC(50) of 32.6 uM for the unphosphorylated form and 43.4 uM for the phosphorylated form (PubMed:21087208). Phosphorylation leads to an increase in the catalytic activity (By similarity).
messages: Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior. In response to food, involved in promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons (PubMed:19609300). Modulates male mating behavior by controlling the protrusion of copulatory spicules from the tail of males during hermaphrodite vulval location (PubMed:23166505).
messages: Plays a role in promoting amphetamine-induced loss of motility in water, termed swimming-induced paralysis.
messages: Reduced (30-40% of wild type) level of dopamine thought to be due to defects in dopamine synthesis. Defects in serotonin signaling. Affects mechanosensory behavior including foraging and exploration activity. Hypersensitivity to odorants. Blocks the enhanced slowing response phenotype caused by bilobalide, a neuroprotective plant chemical. No significant effect on lifespan.
messages: axon
messages: perinuclear region

6239:CELE F57B10.12
gene id: 6239:CELE_F57B10.12
uniprot id: O44740
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline.
messages: Highly expressed in the female germline.
messages: Interacts with mei-1.
messages: spindle pole

6239:CELE F07F6.6
gene id: 6239:CELE_F07F6.6
uniprot id: G5EGQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Membrane

6239:CELE F19F10.9
gene id: 6239:CELE_F19F10.9
uniprot id: O01524
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

6239:CELE T20D3.7
gene id: 6239:CELE_T20D3.7
uniprot id: B3GWB9
uniprot id: L8E917
uniprot id: O01258
names: Function
names: Similarity
messages: Belongs to the VPS26 family.
messages: May play a role in vesicular protein sorting, similar to the yeast retromer proteins.

6239:CELE Y43F4B.5
gene id: 6239:CELE_Y43F4B.5
uniprot id: O45934
uniprot id: Q86DA0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

6239:CELE W05H7.3
gene id: 6239:CELE_W05H7.3
uniprot id: O02173
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: perinuclear region

6239:CELE F32H2.3
gene id: 6239:CELE_F32H2.3
uniprot id: P91870
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Associates with centrosomes, during nearly all of the developmental stages. In the hermaphrodite gonad, it localizes as discrete perinuclear foci in the mitotic portion of the germline. These foci are also evident during the early stages of oogenesis but are absent in mature oocytes. In contrast, in mature sperm these foci are present with each male gamete containing a single dot adjacent to the nucleus. Similarly, in meiotic stage embryos, a single expression dot is observed next to the male pronucleus. In slightly older embryos, one or two perinuclear foci are observed. The intensity of the foci increase with the age of the embryos and at mitosis it localizes to both spindle poles. As embryos progress through anaphase and telophase, the intensity of staining gradually diminishes. Careful examination of the staining pattern at this stage reveals a diffuse expression centered on one or two very bright dots corresponding to both centrioles as well the pericentriolar region.
messages: Required both for centrosome duplication and maturation (PubMed:15068791, PubMed:15186742, PubMed:19081077). Required for pericentriolar material (PCM) recruitment (PubMed:15068791, PubMed:15186742).
messages: centriole
messages: centrosome

6239:CELE F44E2.7
gene id: 6239:CELE_F44E2.7
uniprot id: P34437
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08D9.3
gene id: 6239:CELE_K08D9.3
uniprot id: A0A0S4XRY4
uniprot id: P41990
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: First expressed in late 2-cell stage embryos at the anterior periphery of the P1 blastomere, where P1 contacts the AB blastomere (at protein level) (PubMed:8674418). Maternally expressed in newly fertilised eggs, and present in all blastomeres between 1-cell and 8-cell stages (PubMed:8674418). After the 8-cell stage, rapidly disappears from all somatic blastomeres, and then expressed in P3 blastomere at the 12 cell stage (PubMed:8674418). In 36-cell stage and later embryos, can be detected in one to five unidentified cells (PubMed:8674418). Expressed in the P6.p vulval precursor cell (VPC) during larval L3 stage, coinciding with extension and reflexing of the gonad (PubMed:14960273). Expressed in cells immediately adjacent to ventral mesodermal lineage (M lineage) cells, but not next to dorsal M lineage cells, beginning at the 4-M stage (PubMed:18036582). Expressed in the distal tip cell (DTC) starting in the larval L3 stage (PubMed:19502484). Expressed in the secondary vulval epithelial cells and the non-target vm1 cells at the larval L4 stage (PubMed:23539368).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling (PubMed:14960273, PubMed:7568229, PubMed:8575327). Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs), acting redundantly with dsl-1 and lag-2 (PubMed:14960273, PubMed:7568229). Contributes to the establishment of the dorsal-ventral axis in early embryos (PubMed:8156602, PubMed:18036582). Involved in the specification of the blastomere cell ABp fate, probably acting as a signal from the P2 blastomere to the glp-1/Notch receptor on ABp and ABa (PubMed:8156602, PubMed:7925031, PubMed:8674418). Probably acts as a signal, from the secondary vulval epithelial cells and the vulval muscle type 1 (vm1) cells, to activate the lin-12/Notch pathway in type 2 vulval muscle (vm2) cells, contributing to formation of the postsynaptic muscle plasma membrane extensions, known as muscle arms (PubMed:23539368). Required for oocyte growth control, acting redundantly with lag-2, perhaps signaling via the glp-1/Notch pathway (PubMed:19502484). Plays a somatic role in ovulation during adulthood, perhaps via lin-12/Notch signaling (PubMed:29371032). Involved in establishing left-right asymmetry during intestinal organogenesis (PubMed:10903169).
messages: RNAi-mediated knockdown in the L1 larval stage causes an endomitotic oocyte phenotype; effect not seen if knockdown is targeted to germline, rather than somatic cells (PubMed:29371032). RNAi-mediated knockdown alters ovulation (PubMed:29371032). Spermatheca calcium flux is altered by RNAi-mediated knockdown (PubMed:29371032). RNAi-mediated knockdown, on a lag-2 mutant background, induces the presence of 1-2 extra mesodermal lineage (M lineage)-derived coelomocytes (PubMed:18036582). RNAi-mediated knockdown on a lin-15 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate (PubMed:14960273). On a lag-2 mutant background, RNAi-mediated knockdown causes germ cells to display nuclear morphology consistent with meiotic prophase or gametogenesis in adult hermaphrodites (PubMed:19502484). RNAi-mediated knockdown, when combined with RNAi-mediated knockdown of lag-2, on a dsl-1 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate; phenotype exacerbated on double mutant lin-15;dsl-1 background (PubMed:14960273).

6239:CELE T28F4.2
gene id: 6239:CELE_T28F4.2
uniprot id: Q22851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE F10C5.2
gene id: 6239:CELE_F10C5.2
uniprot id: Q19293
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Contributes to nuclear envelope stiffness in germ cells (By similarity). Required for fertility (PubMed:32923640).
messages: Nucleus inner membrane

6239:CELE Y57A10A.15
gene id: 6239:CELE_Y57A10A.15
uniprot id: Q9U208
names: Subcellular Location Annotation
messages: Mitochondrion

6239:CELE F26A3.3
gene id: 6239:CELE_F26A3.3
uniprot id: G5EBQ3
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE R05D11.5
gene id: 6239:CELE_R05D11.5
uniprot id: Q21737
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

6239:CELE ZK863.6
gene id: 6239:CELE_ZK863.6
uniprot id: Q10661
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dpy-30 family.
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (PubMed:31602465). Within the complex, interacts with cfp-1 and wdr-5.1 (PubMed:31602465). Interacts with jmjd-3.1 (PubMed:25124442).
messages: Essential for dosage compensation (PubMed:7588066). Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes (PubMed:7588066, PubMed:8939869). Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2 (PubMed:23884442). Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442).
messages: Expressed both maternally and zygotically in all stages.
messages: Nucleus
messages: RNAi-mediated knockdown suppresses the growth delay and elevated body fat index of the TOR complex 2 mutant rict-1 (PubMed:23884442). Results in disruption of the invariant transdifferentiation of the Y rectal cell to the PDA motor neuron (PubMed:25124442).

6239:CELE Y4C6B.4
gene id: 6239:CELE_Y4C6B.4
uniprot id: H2L027
uniprot id: Q8ITV2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C26B2.3
gene id: 6239:CELE_C26B2.3
uniprot id: Q18192
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE H10D18.3
gene id: 6239:CELE_H10D18.3
uniprot id: Q9N5N5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T09A5.6
gene id: 6239:CELE_T09A5.6
uniprot id: P45966
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for germ cell development and for transcriptional activation of certain stage-specific inducible promoters.
messages: Component of the Mediator complex.
messages: Nucleus

6239:CELE C12D5.2
gene id: 6239:CELE_C12D5.2
uniprot id: Q17929
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE ZK6.5
gene id: 6239:CELE_ZK6.5
uniprot id: O61868
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F09G8.3
gene id: 6239:CELE_F09G8.3
uniprot id: P34388
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
messages: Mitochondrion

6239:CELE T06D8.5
gene id: 6239:CELE_T06D8.5
uniprot id: Q22251
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

6239:CELE R06F6.6
gene id: 6239:CELE_R06F6.6
uniprot id: Q09602
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C12D8.4
gene id: 6239:CELE_C12D8.4
uniprot id: Q17937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE T05B4.2
gene id: 6239:CELE_T05B4.2
uniprot id: O16425
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE F53F10.3
gene id: 6239:CELE_F53F10.3
uniprot id: O01578
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: May mediate the uptake of pyruvate into mitochondria.
messages: Mitochondrion inner membrane

6239:CELE C18A11.5
gene id: 6239:CELE_C18A11.5
uniprot id: Q23229
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Although clearly related the GHMP kinase family as demonstrated by the 3D-structure, it lacks many conserved feature of GHMP kinases and probably does not bind ATP, suggesting that it probably does not have kinase activity.
messages: Belongs to the GHMP kinase family. Xol-1 subfamily.
messages: Down-regulated by at least 4 X-linked genes, termed X-signal elements including fox-1 and sex-1 (PubMed:9217163). High levels of xol-1 in males correlate with low sdc-2 expression, preventing dosage compensation. Conversely, low levels of xol-1 in hermaphrodites correlate with high sdc-2 expression and the assembly of the dosage compensation complex on the X chromosome.
messages: Inactive isoform (PubMed:7813020, PubMed:33372658). Produced by alternative splicing of intron 6 which results in the retention of intron 6 and deletion of exon 7 coding sequences (PubMed:33372658). An in-frame UAA stop codon within intron 6 prematurely terminates translation (PubMed:7813020). Intron 6 retention and exon 7 deletion can also be due to use of an alternative 3' splice acceptor site in the 3'UTR resulting in trans-splicing to the transcripts of unrelated genes (PubMed:33372658).
messages: Most abundant in male embryos (PubMed:33372658). Expressed at low levels in hermaphrodite embryos (PubMed:33372658).
messages: Nucleus
messages: Only functional isoform (PubMed:33372658). Produced by alternative splicing of intron 6 which results in the deletion of intron 6 and retention of exon 7 coding sequences (PubMed:33372658).
messages: Sex-determining factor that is required for sexual differentiation and X chromosome dosage compensation to promote male development (PubMed:7813020, PubMed:9217163, PubMed:33372658). High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear.
messages: Specifically expressed at high levels in pre-comma stage XO embryos. Also present at low levels throughout other larval stages in XO animals, but are nearly undetectable in XX larvae and adults of both sexes.
messages: Worms are XO-lethal, due to inappropriate activating dosage compensation where only 1 X chromosome is present. In contrast xol-1 overexpression is XX-lethal, deactivating the dosage compensation pathway and elevating the expression of X chromosome genes to lethal levels in hermaphrodites.

6239:CELE F47G4.7
gene id: 6239:CELE_F47G4.7
uniprot id: O02655
names: Cofactor
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Heterotetramer of two alpha and two beta chains.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Reduced body size as compared to wild-type with the production of fewer progeny. Reduced spermidine levels, but increased putrescine accumulation. Double knockout with the polyamine transporter catp-5 results in a reduced brood size, delayed postembryonic development, and a more marked reduction in spermidine levels and a more marked increase in putrescine accumulation as compared to the single mutants.

6239:CELE W09D6.6
gene id: 6239:CELE_W09D6.6
uniprot id: G5EFD4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome
messages: Expressed in coelomocytes, as well as in head and tail neurons, and in the intestinal cells.
messages: Late endosome
messages: May play a pivotal role in the detoxification of heavy metals such as cadmium but do not depend exclusively on phytochelatins (PC) synthesis.
messages: RNAi-mediated knockdown causes hypersensitivity to Cd(2+) and exhibit Cd(2+)-elicited changes in cellular morphology. Even at the lowest Cd(2+) concentrations they arrest in the early larval stages and eventually die. The intestinal epithelial cells of hmt-1 RNAi worms upon exposure to toxic levels of Cd(2+) elaborate punctate refractive inclusions within the vicinity of the nucleus.
messages: Recycling endosome
messages: Vacuole membrane

6239:CELE F28H7.4
gene id: 6239:CELE_F28H7.4
uniprot id: Q19892
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SelWTH family. SELT subfamily.
messages: Cytoplasm
messages: Exclusively expressed in AWB chemosensory amphid neurons.
messages: Expressed from the L1 stage of larval development to adults.
messages: Perikaryon
messages: Probably has thioredoxin reductase-like oxidoreductase activity.
messages: Viable with normal development, anatomy, motility, lifespan and brood size. Double knockouts with selt-1.1 are also viable with no visible phenotype.
messages: axon
messages: dendrite

6239:CELE F32A6.5
gene id: 6239:CELE_F32A6.5
uniprot id: Q19958
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: May be involved in cilia-related function.
messages: Membrane

6239:CELE F11G11.3
gene id: 6239:CELE_F11G11.3
uniprot id: P91252
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Sigma family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

6239:CELE M04G12.3
gene id: 6239:CELE_M04G12.3
uniprot id: P92006
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221).
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE C01G8.5
gene id: 6239:CELE_C01G8.5
uniprot id: G5EBK3
uniprot id: G5EES2
names: Subcellular Location Annotation
messages: Membrane
messages: adherens junction
messages: cytoskeleton

6239:CELE Y106G6H.7
gene id: 6239:CELE_Y106G6H.7
uniprot id: Q9XWS2
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Pseudocoelom.
messages: The exocyst complex is composed of sec-3/exoc1, sec-5/exoc2, sec-6/exoc3, sec-8/exoc4, sec-10/exoc5, sec-15/exoc6, exo-70/exoc7 and exo-84/exoc8.

6239:CELE K02F3.6
gene id: 6239:CELE_K02F3.6
uniprot id: G5EBI4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active against epoxyeicosatrienoic acids (EETs) including 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (8,9-EET), 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate (11,12-EET) and 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate (14,15-EET) and the linoleic acid metabolites 12,13-epoxy-(9Z)-octadecenoate (12,13-EpOME) and 9,10-epoxy-(12Z)-octadecenoate (9,10-EpOME). These epoxides function as lipid signaling molecules, the enzyme can deplete the supply of the epoxide signal by transforming them into diol species that are more readily eliminated through excretion.
messages: Membrane
messages: RNAi knockdown of both ceeh-1 and ceeh-2 results in the accumulation of 9,10-EpOME and 12,13-EpOME.

6239:CELE C44B7.10
gene id: 6239:CELE_C44B7.10
uniprot id: Q18599
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

6239:CELE R06C1.1
gene id: 6239:CELE_R06C1.1
uniprot id: G5ECH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

6239:CELE F53F1.5
gene id: 6239:CELE_F53F1.5
uniprot id: P34682
names: Developmental Stage
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Component of the insoluble part of the cuticles.
messages: Expressed before the L1 to L2 stage molt.
messages: Secreted
messages: The small repeats A-A-P-[AVI] are also present in many proteins constituting the protective envelope of other species.
messages: Tyrosine residues can be cross-linked in vitro, leading to the formation of insoluble high molecular-weight complexes.

6239:CELE C40C9.1
gene id: 6239:CELE_C40C9.1
uniprot id: G5ECW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C38H2.1
gene id: 6239:CELE_C38H2.1
uniprot id: I2HAA0
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the RUTBC family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Expressed in neurons in the head, tail and ventral nerve cord (at protein level).
messages: Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others (PubMed:22654674). GTPase activator for rab-2 (PubMed:22654674). In association with ric-19 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons (PubMed:22654674).
messages: Interacts with rab-19 (PubMed:22654674). Interacts with ric-19; the interaction is direct and may be required for the activation of rab-2 and dense vesicle maturation in cholinergic motoneurons (PubMed:22654674). Interacts (via RUN domain) with rund-1 (PubMed:24698274). Does not interact with unc-108 (GTP-bound form) (PubMed:22654674).
messages: RNAi-mediated knockdown results in neuronal dense core vesicle trafficking defects whereby fewer dense core vesicles are transported to axons of the dorsal nerve cord.
messages: trans-Golgi network

6239:CELE F09C6.8
gene id: 6239:CELE_F09C6.8
uniprot id: O45328
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T11G6.8
gene id: 6239:CELE_T11G6.8
uniprot id: Q22412
names: Similarity
messages: Belongs to the SLT11 family.

6239:CELE B0546.1
gene id: 6239:CELE_B0546.1
uniprot id: O44441
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mai-2 and tin-9.2 are transcribed on a dicistronic transcript where exos-4.1 is the upstream transcript and tin-9.2 the downstream.
messages: Mitochondrion
messages: Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. Activity is pH dependent.

6239:CELE T21D9.1
gene id: 6239:CELE_T21D9.1
uniprot id: Q22651
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE T01D3.2
gene id: 6239:CELE_T01D3.2
uniprot id: P90953
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Expressed in a small subset of neurons, probably AVJL and AVJR (PubMed:22768843). Expressed in the AVH neurons (PubMed:34604715).
messages: Nucleus
messages: Transcription factor (By similarity). Involved in specifying AVH neuron identity, acting in concert with unc-42 (PubMed:34165428). Involved in serotonin-mediated feeding behavior, probably acting by modulating expression of genes involved in glutamate signaling (PubMed:22768843).
messages: Was reported to probably be expressed in the AVJL and AVJR neurons (PubMed:22768843). However, this has been claimed to be an anatomical error and that expression is restricted to the AVH neurons (PubMed:34604715).

6239:CELE Y75B12B.10
gene id: 6239:CELE_Y75B12B.10
uniprot id: Q86DA9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE D1014.6
gene id: 6239:CELE_D1014.6
uniprot id: Q95ZW7
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE K12D9.3
gene id: 6239:CELE_K12D9.3
uniprot id: P91378
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE AH6.4
gene id: 6239:CELE_AH6.4
uniprot id: Q09203
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C06G3.11
gene id: 6239:CELE_C06G3.11
uniprot id: Q17754
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim-9/tin-9.1 and 3 copies of tim-10/tin-10, named soluble 70 kDa complex. The complex associates with the tim-22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit (By similarity).
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable).
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim-9/tin-9.1 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).
messages: Worms display a small body size, reduced number of progeny produced and partial embryonic lethality due to defects in import of proteins into mitochondria.

6239:CELE Y37D8A.18
gene id: 6239:CELE_Y37D8A.18
uniprot id: Q9XWV5
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Induction of dauer formation and larval arrest. Reduced insulin/IGF signaling.
messages: Mitochondrion
messages: Ribosomal protein required for normal mitochondrial function and normal larval development. Thought to have a role in insulin/IGF signaling.

6239:CELE K07C5.5
gene id: 6239:CELE_K07C5.5
uniprot id: G5EDL5
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME).
messages: Less active when compared to ceeh-1.
messages: RNAi knockdown of both ceeh-1 and ceeh-2 results in the accumulation of 9,10-EpOME and 12,13-EpOME.

6239:CELE F43D9.3
gene id: 6239:CELE_F43D9.3
uniprot id: A7LPF3
uniprot id: Q20364
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

6239:CELE ZK1128.2
gene id: 6239:CELE_ZK1128.2
uniprot id: Q09357
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the methyltransferase superfamily. METTL16/RlmF family.
messages: Expressed in the intestine, vulva, and cells of the somatic gonad including distal tip cells, gonadal sheath cells and spermatheca.
messages: Nucleus
messages: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289). Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:33930289). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194). Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194). Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901).
messages: Self-associates (PubMed:19752194). Interacts with dlc-1; the interaction is direct, and is required for nuclear localization of mett-10 (PubMed:19752194).

6239:CELE C18B12.3
gene id: 6239:CELE_C18B12.3
uniprot id: Q93246
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in the bilateral sensory neurons AWA, AWB, AWC, ASE, FLP and PVD. Also expressed in the enteric intestinal and anal depressor muscles.
messages: Nucleus
messages: Shortened defecation cycle length with change in periodicity of the cycle. Expulsion defective with distended gut and lack of enteric muscle contractions due to lack of exp-1 expression.
messages: Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle.
messages: axon

6239:CELE C49H3.1
gene id: 6239:CELE_C49H3.1
uniprot id: Q9GYQ4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed bilaterally in AFD sensory neurons.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:27062922). Regulates thermotaxis responses in AFD sensory neurons (PubMed:16415369, PubMed:21315599, PubMed:27062922). May regulate AFD neuronal activity such as calcium responses to temperature gradients (PubMed:16415369, PubMed:21315599). Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3 (PubMed:27062922). cGMP levels antagonize the actin cytoskeleton regulator wsp-1 (PubMed:27062922).
messages: Inhibited by chloride with an IC(50) of 60 mM.
messages: The guanylate cyclase domain is required for thermotaxis responses.
messages: The protein kinase domain is predicted to be catalytically inactive. Might be required for the negative regulation of the guanylate cyclase domain (PubMed:27062922).
messages: cilium

6239:CELE ZC84.3
gene id: 6239:CELE_ZC84.3
uniprot id: Q03609
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules.
messages: cytoskeleton

6239:CELE R09G11.2
gene id: 6239:CELE_R09G11.2
uniprot id: Q21878
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor which acts in concert with the insulin/IGF-1-like signaling (IIS) pathway during osmotic stress, perhaps in response to a ligand modified by the sulfotransferase ssu-1.

6239:CELE ZK1067.1
gene id: 6239:CELE_ZK1067.1
uniprot id: A0A0K3AX35
uniprot id: B5BM27
uniprot id: B5BM28
uniprot id: P24348
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Expressed during L2 and L3 larval stages (PubMed:10359617). Highly expressed in vulval precursor cells P6.p in late L2 and early L3 stage larvae (PubMed:32053105).
messages: Expressed in vulval precursor cells (at protein level) (PubMed:10359617). Expressed in ALA neurons, 2 ventral head neurons, a single neuron in the tail, pharyngeal-intestinal valve and posterior arcade epithelial cells (PubMed:17891142).
messages: Larval lethality, lack of vulva formation, infertility and lack of male spicule formation (PubMed:2071015). RNAi-mediated knockdown causes sterility, a small decrease in the peak rate of sheath cell contractions and a delay in the onset of ovulatory contractions (PubMed:15194811). Restores normal pharyngeal pumping rate in 30 percent of animals overexpressing lin-3 (PubMed:17891142).
messages: Membrane
messages: Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis (PubMed:2071015, PubMed:8313880, PubMed:9491893, PubMed:20230814, PubMed:32053105). Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade downstream of ligand lin-3, plays a role in ovulation by promoting ovulatory gonadal sheath cell contractions (PubMed:9491893, PubMed:15194811). Probably by regulating neuronal transmission in ALA neurons, mediates, independently of let-60/Ras, the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and upstream of plc-3 (PubMed:17891142).

6239:CELE M176.6
gene id: 6239:CELE_M176.6
uniprot id: P34891
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Expressed during hypodermal development.
messages: Hypodermal cells.
messages: May be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development. It has a role in the development of the HYP7 hypodermal syncytium.

6239:CELE T10E10.2
gene id: 6239:CELE_T10E10.2
uniprot id: Q22379
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F32E10.8
gene id: 6239:CELE_F32E10.8
uniprot id: Q95QH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F18G5.3
gene id: 6239:CELE_F18G5.3
uniprot id: Q19572
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families (PubMed:22470487, PubMed:19380113). Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:19380113).
messages: Up-regulation of nlp-29 is severely impaired in the hyp7 epidermal cell but not in vulva epidermal cells following fungal infection by D.coniospora or physical injury.

6239:CELE T13C5.5
gene id: 6239:CELE_T13C5.5
uniprot id: Q22460
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Binds 1 zinc ion per subunit.
messages: Oligomer.
messages: Reversible hydration of carbon dioxide.

6239:CELE F40H3.4
gene id: 6239:CELE_F40H3.4
uniprot id: H2KZ39
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C36H8.2
gene id: 6239:CELE_C36H8.2
uniprot id: Q9U3N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE B0035.6
gene id: 6239:CELE_B0035.6
uniprot id: Q17436
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasmic granule
messages: May interact with deps-1 and prg-1.
messages: Plays a role in regulating deps-1 cluster formation in the germline.
messages: RNAi-mediated knockdown results in enlarged deps-1-containing clusters.

6239:CELE F58G6.8
gene id: 6239:CELE_F58G6.8
uniprot id: A0A8D6UGU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE W08D2.6
gene id: 6239:CELE_W08D2.6
uniprot id: Q23222
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C54E4.3
gene id: 6239:CELE_C54E4.3
uniprot id: Q6DNF3
names: Activity Regulation
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 or 2 heme groups per heterodimer.
messages: Cytoplasm
messages: Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.
messages: Heterodimer; with other soluble guanylate cyclases.
messages: May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).
messages: Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons.
messages: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

6239:CELE Y110A7A.8
gene id: 6239:CELE_Y110A7A.8
uniprot id: Q9N592
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

6239:CELE C36E6.5
gene id: 6239:CELE_C36E6.5
uniprot id: P19626
names: Miscellaneous
names: Subunit
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: This chain binds calcium.

6239:CELE C26F1.9
gene id: 6239:CELE_C26F1.9
uniprot id: P52814
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL39 family.
messages: Interacts with impact.

6239:CELE D2023.3
gene id: 6239:CELE_D2023.3
uniprot id: E0AHC8
uniprot id: P90785
names: Similarity
messages: Belongs to the synaptotagmin family.

6239:CELE R07G3.9
gene id: 6239:CELE_R07G3.9
uniprot id: Q5WRU0
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Disrupted localization of levamisole-sensitive nicotinic acetylcholine receptor subunits in 80% of mutants, and this is mostly in conjunction with the disrupted localization of the associated transmembrane protein lev-10 and secreted protein lev-9. This results in increased sensitivity to the acetylcholine agonist levamisole.
messages: Expressed in body wall muscle cells, the pharyngeal muscle cell pm6 and in four head neurons.
messages: Interacts with the non-alpha subunit of nicotinic acetylcholine receptor unc-29 and lev-10 to stabilize the complex formed between unc-29 and lev-10.
messages: Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation.
messages: Secreted
messages: Synapse

6239:CELE F46C3.3
gene id: 6239:CELE_F46C3.3
uniprot id: B6VQ62
uniprot id: D3YT13
uniprot id: D3YT14
uniprot id: S6EZR2
uniprot id: S6FD20
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

6239:CELE F32D8.6
gene id: 6239:CELE_F32D8.6
uniprot id: Q19967
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Expressed in the germline (PubMed:8707849). Expression in the germline is regulated in a sex- and meiotic cycle stage-specific manner (PubMed:8707849). Expressed in somatic tissues including the intestine and somatic gonad (PubMed:8707849). Expressed in the intestine more highly in hermaprodites than in males (PubMed:8707849). In hermaphrodites, weakly expressed in the spermatheca (PubMed:8707849).
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Required for oocyte development and ovulation (PubMed:8707849, PubMed:12533508). Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro (PubMed:8707849).

6239:CELE Y57G11C.44
gene id: 6239:CELE_Y57G11C.44
uniprot id: F5GUJ1
uniprot id: Q7YTI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE C18D1.2
gene id: 6239:CELE_C18D1.2
uniprot id: Q09479
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C49H3.3
gene id: 6239:CELE_C49H3.3
uniprot id: Q9GYQ6
names: Similarity
messages: Belongs to the learning-associated protein family.

6239:CELE ZK1127.7
gene id: 6239:CELE_ZK1127.7
uniprot id: G5ECQ8
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the type II topoisomerase family.
messages: Lacks the conserved ATP binding sites, the conserved active site tyrosine at position 404, the conserved isoleucine at position 455 important for DNA bending, and the conserved magnesium binding site at position 143, and therefore probably lacks topoisomerase activity.
messages: Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution.
messages: RNAi-mediated knockdown leads to impaired removal of the cohesin component scc-1 from kinetochores on mitotic metaphase chromosomes.

6239:CELE T22D1.4
gene id: 6239:CELE_T22D1.4
uniprot id: Q9GZH4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Cytoplasmic granule
messages: Endoplasmic reticulum membrane
messages: RNAi-mediated knock-down is mostly embryonic lethal (PubMed:23691084). Embryos exhibit cytokinesis defects which lead to arrest during development (PubMed:23691084). Embryogenesis proceeds more slowly and embryos are osmo-sensitive (PubMed:23691084). Defective localization of the yolk receptor rme-2 and impaired yolk secretion (PubMed:23691084). May result in chromosome segregation defects (PubMed:23691084).
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6239:CELE Y47D3A.23
gene id: 6239:CELE_Y47D3A.23
uniprot id: Q9U2C4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
messages: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.
messages: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

6239:CELE Y48G9A.10
gene id: 6239:CELE_Y48G9A.10
uniprot id: Q9N3N3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

6239:CELE ZK546.14
gene id: 6239:CELE_ZK546.14
uniprot id: G8JYE5
uniprot id: Q23525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF6 family.
messages: nucleolus

6239:CELE F56A8.7
gene id: 6239:CELE_F56A8.7
uniprot id: O16000
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the syntaxin family.
messages: Expressed throughout the head ganglion, nerve ring, ventral cord, dorsal cord, intestine, vulva and spermatheca.
messages: Interacts with unc-18.
messages: Membrane
messages: Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:1945043, PubMed:9442061). Essential for embryonic viability and development. Has a role in dauer formation and adult life span (PubMed:10377425). Required for locomotion (PubMed:10377425). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt (PubMed:17891142).
messages: Worms exhibit defects in locomotion and postembryonic development. All mutants are resistant to the acetylcholinesterase inhibitor aldicarb indicating impaired cholinergic transmission.

6239:CELE Y32H12A.5
gene id: 6239:CELE_Y32H12A.5
uniprot id: Q9N536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6239:CELE ZK697.14
gene id: 6239:CELE_ZK697.14
uniprot id: Q7KPV7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE W08E12.1
gene id: 6239:CELE_W08E12.1
uniprot id: Q9N5A8
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: By exposure to the Gram-negative bacterium P.aeruginosa strain PA14.
messages: Expressed in intestine, pharynx, and hypodermis at larval stage L4.
messages: Interacts with CCAAT/enhancer-binding protein cebp-2.
messages: Nucleus
messages: RNAi-mediated knockdown targeted to the intestine, but not to neurons, hypodermis, muscle or germline, reduced the resistance to infection by the Gram-positive bacterium P.aeruginosa strain PA14 (PubMed:34804026). Reduces expression of pmk-1 pathway dependent genes, such as systemic stress signaling mediator sysm-1 and infection response gene irg-4 (PubMed:34804026).
messages: Transcription factor (By similarity). Involved in modulating innate immune response pathways, acting to promote resistance against infection by Gram-negative bacterium P.aeruginosa strain PA14 (PubMed:34804026). May act as part of a feedback regulatory loop with the pmk-1/p38 MAPK pathway (PubMed:34804026). May also function in concert with CCAAT/enhancer-binding protein cebp-2 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway (PubMed:34804026).

6239:CELE T09F5.1
gene id: 6239:CELE_T09F5.1
uniprot id: O62375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE ZK550.2
gene id: 6239:CELE_ZK550.2
uniprot id: O62511
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C34H4.4
gene id: 6239:CELE_C34H4.4
uniprot id: Q86S35
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F41H10.8
gene id: 6239:CELE_F41H10.8
uniprot id: Q20303
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ELO family.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme required for the formation of isoheptadecanoate (C17iso), which plays critical roles in animal development and growth.
messages: Expressed in the gut, neurons, pharynx and muscles of the vulva.
messages: Membrane

6239:CELE B0495.8
gene id: 6239:CELE_B0495.8
uniprot id: G8JXY3
uniprot id: Q09217
names: Similarity
messages: Belongs to the Luc7 family.

6239:CELE Y39G10AR.3
gene id: 6239:CELE_Y39G10AR.3
uniprot id: A0A061AD48
uniprot id: A0A061AJL2
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

6239:CELE W05B2.6
gene id: 6239:CELE_W05B2.6
uniprot id: Q9XVG3
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F53C3.13
gene id: 6239:CELE_F53C3.13
uniprot id: H2KZD1
uniprot id: H2KZD2
uniprot id: Q9TXU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

6239:CELE Y41D4A.6
gene id: 6239:CELE_Y41D4A.6
uniprot id: Q95Y25
uniprot id: U4PC78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

6239:CELE F58B3.1
gene id: 6239:CELE_F58B3.1
uniprot id: Q20964
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

6239:CELE Y18D10A.17
gene id: 6239:CELE_Y18D10A.17
uniprot id: Q9XW17
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LSM14 family.
messages: Nucleus
messages: RNAi-mediated knockdown significantly reduces protein levels of ATP-dependent chaperones cdc-48.1 and cdc-48.2 in embryos.
messages: Transcriptional regulator (PubMed:18430416). Involved in modulating embryonic expression of ATP-dependent chaperone cdc-48.1 (PubMed:18430416). May play a role in mRNA gene silencing, and RNA granule (P-body) assembly (PubMed:29510985).

6239:CELE Y77E11A.6
gene id: 6239:CELE_Y77E11A.6
uniprot id: Q9N4B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

6239:CELE Y34D9A.6
gene id: 6239:CELE_Y34D9A.6
uniprot id: Q9N456
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

6239:CELE C42C1.5
gene id: 6239:CELE_C42C1.5
uniprot id: A3QMC8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

6239:CELE T19D2.2
gene id: 6239:CELE_T19D2.2
uniprot id: G5EG43
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

6239:CELE F25H8.3
gene id: 6239:CELE_F25H8.3
uniprot id: H2L2A7
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R09H10.3
gene id: 6239:CELE_R09H10.3
uniprot id: Q21882
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.

6239:CELE Y11D7A.12
gene id: 6239:CELE_Y11D7A.12
uniprot id: Q9XWR1
names: Developmental Stage
names: Disruption Phenotype
names: Function
messages: Expressed during embryogenesis and adulthood (at protein level) (PubMed:18794349). Expressed in most cells starting at gastrulation and diminishing by the L1 larval stage; however, also expressed in L4 larval stage and adults (PubMed:18794349).
messages: Knockout, in a flh-2 mutant background, causes poor coordination, egg-laying defects and dumpy appearance (PubMed:18794349). Causes a ninefold to 10-fold decrease in lin-14 level in embryos and about 2-fold increase in the levels of micro-RNAs lin-4 and mir-241 (PubMed:18794349). Despite the increase in lin-4 expression, post-embryonic heterochronic defects are not observed (PubMed:18794349). RNAi-mediated knockdown causes precocious embryonic expression of micro-RNA lin-4, exacerbated by simultaneous RNAi-mediated knockdown of flh-2 (PubMed:18794349).
messages: Probable transcription factor (PubMed:18794349). Binds to the DNA sequence motif 5'-[AG]GGCGCCG-3' in the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2 (PubMed:18794349).

6239:CELE F36A4.8
gene id: 6239:CELE_F36A4.8
uniprot id: Q20089
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F57F5.1
gene id: 6239:CELE_F57F5.1
uniprot id: Q20950
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y17G7B.4
gene id: 6239:CELE_Y17G7B.4
uniprot id: Q9XXJ0
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

6239:CELE R53.3
gene id: 6239:CELE_R53.3
uniprot id: Q22024
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Dispensable for anchor cell (AC) invasion and for preventing AC proliferation.
messages: Expressed in the hermaphrodite-specific motor neuron (HSN) / phasmid sensory neuron B (PHB) precursor, and the phasmid sensory neuron A (PHA) in the tail at ~400 minutes embryogenesis (at protein level) (PubMed:10049362). Continues to be expressed in PHA and PHB neurons of L1 larvae (PubMed:10049362). Expressed in the HSN before and during HSN migration from the tail to the gonad primordium of the embryo and down-regulated after migration (at protein level) (PubMed:10049362). Expressed in the pre-anchor cell (AC)/pre-ventral uterine (VU) cells at early L2 and maintained in their 37 descendants at early L4 (PubMed:17215301, PubMed:32203506).
messages: Expressed in the ventral uterine (VU) cells of mid L2 larvae (Pn.p stage) and then in the anchor cell (AC) beginning in mid L3 larvae (PubMed:17573066, PubMed:32203506). Expression increases during AC invasion (PubMed:17573066).
messages: Expressed, earlier than isoform a, in the anchor cell (AC) at the Pn.p stage in mid L2 larvae (PubMed:17573066). Expression decreases during AC invasion (PubMed:17573066).
messages: No defects in anchor cell (AC) invasion or arrest in G1 seen upon RNAi-mediated knockdown.
messages: Nucleus
messages: Probable transcription factor, involved in lin-12 (Notch)-dependent anchor cell (AC) and ventral uterine (VU) precursor cell fate specification and in AC invasion (PubMed:17215301, PubMed:17573066, PubMed:32203506). Prevents AC proliferation after AC cell specification by repressing lin-12 expression (PubMed:32203506). May form a positive feedback loop, together with the transcription factor fos-1, that maintains mutual high levels of expression and so activates AC invasion (PubMed:32203506).
messages: Probable transcription factor, required for migration of the hermaphrodite-specific motor neurons (HSNs) from the tail to the gonad primordium during HSN cell differentiation (PubMed:8224840, PubMed:10049362). Required for phasmid neuron development (PubMed:8224840). Required to specify the pi-cell fate of ventral uterine precursor cell (VU) cells (PubMed:17573066).
messages: RNAi-mediated knockdown causes defects in anchor cell (AC) and ventral uterine (VU) precursor cell specification and AC invasion in the larval L3 and L4 stages (PubMed:17215301, PubMed:17573066). RNAi-mediated knockdown on a lin-12 mutant background reverses the AC-deficient phenotype (PubMed:17215301). RNAi-mediated knockdown reduces expression of zmp-1, cdh-3 and him-4 in the AC (PubMed:17215301, PubMed:17573066). RNAi-mediated knockdown reduces expression of fos-1a in the anchor cell (AC) approximately three-fold (PubMed:32203506). RNAi-mediated knockdown causes defects in vulval morphogenesis (PubMed:17573066).
messages: RNAi-mediated knockdown causes defects in anchor cell (AC) invasion, including increased CDK activity and re-entry of the AC into the cell cycle, resulting in the presence of two or more AC.
messages: The C2H2-type zinc-finger domains 1, 2 and 3 are dispensable for anchor cell (AC) invasion and preventing AC proliferation.
messages: The C2H2-type zinc-finger domains 4 and 5 may be required for anchor cell (AC) invasion and preventing AC proliferation.
messages: The positive regulatory (PR) domain is required for egl-43 protein stability but is dispensable for anchor cell (AC) invasion and preventing AC proliferation.

6239:CELE F14H3.11
gene id: 6239:CELE_F14H3.11
uniprot id: O45365
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE C29F3.2
gene id: 6239:CELE_C29F3.2
uniprot id: Q94130
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE T24D1.4
gene id: 6239:CELE_T24D1.4
uniprot id: O02332
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE K12G11.2
gene id: 6239:CELE_K12G11.2
uniprot id: O17951
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

6239:CELE D2089.5
gene id: 6239:CELE_D2089.5
uniprot id: Q19000
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

6239:CELE T08G5.10
gene id: 6239:CELE_T08G5.10
uniprot id: P17512
names: Domain
names: Function
names: Induction
names: Similarity
messages: All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.
messages: Belongs to the metallothionein superfamily. Type 6 family.
messages: By cadmium.
messages: This protein binds cations of several transition elements.

6239:CELE F19B6.4
gene id: 6239:CELE_F19B6.4
uniprot id: Q19585
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

6239:CELE T13C5.8
gene id: 6239:CELE_T13C5.8
uniprot id: Q8T3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFP1 family.
messages: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity).
messages: Mitochondrion inner membrane

6239:CELE W09C5.6
gene id: 6239:CELE_W09C5.6
uniprot id: Q9U332
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

6239:CELE Y24D9A.8
gene id: 6239:CELE_Y24D9A.8
uniprot id: Q966C7
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

6239:CELE T22C1.10
gene id: 6239:CELE_T22C1.10
uniprot id: Q22670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm
messages: Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
messages: The Rab3 GTPase-activating complex is a heterodimer composed of rbg-1 and rbg-2.

6239:CELE F57G9.7
gene id: 6239:CELE_F57G9.7
uniprot id: G5EBZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Membrane

6239:CELE Y57G11B.97
gene id: 6239:CELE_Y57G11B.97
uniprot id: B3GWE1
uniprot id: K8ESJ6
names: Similarity
messages: Belongs to the globin family.

6239:CELE T01G5.2
gene id: 6239:CELE_T01G5.2
uniprot id: O18009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE C45B11.6
gene id: 6239:CELE_C45B11.6
uniprot id: A4UVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Endoplasmic reticulum membrane

6239:CELE T07C12.12
gene id: 6239:CELE_T07C12.12
uniprot id: G5EF82
names: Similarity
messages: Belongs to the RMI1 family.

6239:CELE C09H6.1
gene id: 6239:CELE_C09H6.1
uniprot id: O17582
names: Disruption Phenotype
names: Function
names: Induction
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in neurons.
messages: Loss of function results in a suppression of sel-12 phenotypes, possibly by up-regulating hop-1 expression.
messages: Nucleus
messages: Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12668626, PubMed:24670762). Might play a role in the oxidative stress response (PubMed:24670762).
messages: RNAi-mediated knockdown results in reduced survival upon paraquat treatment to induce oxidative stress.
messages: Up-regulated by oxidative stress.

6239:CELE T15B7.11
gene id: 6239:CELE_T15B7.11
uniprot id: A0A131MBP5
uniprot id: A0A131MBW3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F08F1.9
gene id: 6239:CELE_F08F1.9
uniprot id: O17384
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE F22D3.2
gene id: 6239:CELE_F22D3.2
uniprot id: J7S130
uniprot id: K0M7B5
uniprot id: S6FCY3
uniprot id: S6FMZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

6239:CELE F32D1.3
gene id: 6239:CELE_F32D1.3
uniprot id: O16296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane
messages: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

6239:CELE F55A11.5
gene id: 6239:CELE_F55A11.5
uniprot id: Q20800
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acyltransferase required for the fatty acid remodeling of phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI). Mediates the conversion of lysophosphatidylinositol (2-acylglycerophosphatidylinositol or LPI) into PI (LPIAT activity). Has preference for saturated and mono-unsaturated fatty acids as acyl donors and sn-2-acyl lysoPI (2-acyl-sn-glycero-3-phospho-D-myo-inositol) as acyl acceptor. Contributes to the asymmetric cell division of epithelial cells. Asymmetric cell division is the fundamental mechanism by which multicellular organisms generate cell diversity.
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Expressed in seam cells, vulval epithelial cells and the major epithelial syncytium hyp7, and in several head neurons including AIY interneurons.
messages: Mutants showed defects in vulval morphology and in the asymmetric division of stem cell-like epithelial cells.

6239:CELE C07G2.2
gene id: 6239:CELE_C07G2.2
uniprot id: Q86MD3
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family.
messages: Chromosome
messages: Expressed in intestinal cells.
messages: Interacts with serine/threonine kinase pmk-1; perhaps in a manner dependent on dual specificity protein kinase sek-1.
messages: Nucleus
messages: RNAi-mediated knockdown increases susceptibility to infection by the Gram-negative bacterium P.aeruginosa (PubMed:20369020). Up-regulates expression of metallothionein mtl-1 (PubMed:28632756).
messages: Transcription factor which regulates the transcription of various genes, including those involved in innate immunity and oxidative stress responses (PubMed:20369020, PubMed:28632756, PubMed:30789901). Binds to promoter regions of genes, probably at 5'-[GACGTCA]-3' consensus sequences (PubMed:30789901). Together with transcription factor daf-19, involved in regulation of the serotonergic response of ADF neurons to pathogenic food (PubMed:23505381). Modulates response to infection by the Gram-negative bacterium P.aeruginosa, acting downstream of the p38 signal transduction pathway effector serine/threonine kinase pmk-1 (PubMed:20369020, PubMed:30789901). May act with transcription factor elt-2 to control p38 gene induction in response to bacterial infection (PubMed:26016853). May be phosphorylated by pmk-1 (PubMed:20369020). Regulates transcription of the metallothionein gene, mtl-1, perhaps acting downstream of pmk-1 (PubMed:28632756).

6239:CELE Y54G2A.29
gene id: 6239:CELE_Y54G2A.29
uniprot id: Q9N397
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F45F2.6
gene id: 6239:CELE_F45F2.6
uniprot id: Q22977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE F47G3.4
gene id: 6239:CELE_F47G3.4
uniprot id: G4S7A1
names: Subcellular Location Annotation
messages: Secreted

6239:CELE T18D3.9
gene id: 6239:CELE_T18D3.9
uniprot id: Q7YWV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Involved in mitochondria homeostasis.
messages: Mitochondrion inner membrane

6239:CELE C55A6.6
gene id: 6239:CELE_C55A6.6
uniprot id: O17721
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6239:CELE C08F8.6
gene id: 6239:CELE_C08F8.6
uniprot id: Q17825
names: Similarity
messages: Belongs to the protein kinase superfamily.

6239:CELE Y37H9A.6
gene id: 6239:CELE_Y37H9A.6
uniprot id: Q9U2M7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.
messages: Belongs to the Nudix hydrolase family.
messages: Divalent metal ions. Mg(2+), Co(2+), Mn(2+), Zn(2+) or Ca(2+).
messages: Monomer.
messages: Mutagenesis suggests that interactions with P1- and P4-phosphate are minimum indicating the enzyme may have a wide substrate range.

6239:CELE Y38F2AL.2
gene id: 6239:CELE_Y38F2AL.2
uniprot id: Q9N423
names: Subcellular Location Annotation
messages: cilium basal body

6239:CELE Y51B9A.6
gene id: 6239:CELE_Y51B9A.6
uniprot id: B6GUQ1
uniprot id: Q9XXC1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58A4.14
gene id: 6239:CELE_F58A4.14
uniprot id: Q5CZ52
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS4 family.
messages: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). May be required for microtubule anchoring at the centrosome but not for microtubule nucleation (By similarity). May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity). Required, redundantly with bbs-5, for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:22922713, PubMed:26150102). Plays a role in the removal of degraded mechanosensory receptors within the cilia (PubMed:26150102).
messages: Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9 (By similarity). Interacts (via C-terminus) with bbs-5; the interaction is direct (PubMed:26150102).
messages: Single mutants do not display any obvious defects in ciliogenesis. Double bbs-4 and bbs-5 mutants display a defect in cilia structure and function. This is characterized by an increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins along the ciliary axoneme. Double mutants also have defective polycystin-mediated cilia signaling and mislocalized and increased accumulation of mechanosensory receptors pkd-2, osm-9 and odr-10 within cilia.
messages: centrosome
messages: cilium membrane
messages: cytoskeleton

6239:CELE F29C12.4
gene id: 6239:CELE_F29C12.4
uniprot id: Q9XV52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

6239:CELE R12C12.1
gene id: 6239:CELE_R12C12.1
uniprot id: Q21962
uniprot id: Q86LS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE T09E8.3
gene id: 6239:CELE_T09E8.3
uniprot id: Q22361
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the cornichon family.
messages: Endoplasmic reticulum membrane
messages: Hyperreversal phenotype with considerably shorter average forward time than wild-type and a corresponding increase in frequency of reversals. Increased anterograde transport of glr-1 with corresponding increases in synaptic glr-1 expression and glr-1-mediated currents. Altered pattern of glr-1 glycosylation, indicative of increased export from the endoplasmic reticulum.
messages: Interacts with glr-1.
messages: Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses.
messages: Synapse
messages: Widely expressed in the nervous system including in the AVA interneurons.
messages: dendrite

6239:CELE C05D11.2
gene id: 6239:CELE_C05D11.2
uniprot id: Q11182
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS16 family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (PubMed:26783301). Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (By similarity). Within the HOPS complex, contributes to the normal development of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423, PubMed:25273556). The CORVET complex is proposed to function as a rab-5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for recruitment of vps-33.1 to the HOPS complex (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with vps-33.1 but not vps-33.2 (By similarity).
messages: Probable core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins vps-11, vps-16 and vps-18, which in HOPS further associates with vps-33.1, vps-39 and vps-41 and in CORVET with vps-8 and vps-33.2.
messages: Viable with a reduced number of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423). Embryos of these adults arrest in early development and lack gut granules (PubMed:15843430). Endosome/lysosome fusion defects in coelomocytes (PubMed:26783301). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen and large endosomes/lysosomes on the basal side of the cell (PubMed:25273556).

6239:CELE C01B4.7
gene id: 6239:CELE_C01B4.7
uniprot id: A0A0M7RFG7
uniprot id: G5EDZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F48F7.7
gene id: 6239:CELE_F48F7.7
uniprot id: Q20577
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE H23N18.1
gene id: 6239:CELE_H23N18.1
uniprot id: Q9TXZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T01H10.3
gene id: 6239:CELE_T01H10.3
uniprot id: Q22081
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE C27B7.6
gene id: 6239:CELE_C27B7.6
uniprot id: P48460
names: Cofactor
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.

6239:CELE E02H1.6
gene id: 6239:CELE_E02H1.6
uniprot id: Q09527
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis.
messages: Nucleus
messages: Suppresses worm growth.

6239:CELE T06G6.9
gene id: 6239:CELE_T06G6.9
uniprot id: O18054
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6239:CELE C39E9.10
gene id: 6239:CELE_C39E9.10
uniprot id: Q18545
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6239:CELE B0303.11
gene id: 6239:CELE_B0303.11
uniprot id: P34261
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane

6239:CELE B0511.8
gene id: 6239:CELE_B0511.8
uniprot id: O61818
names: Subcellular Location Annotation
messages: Mitochondrion

6239:CELE K03B8.3
gene id: 6239:CELE_K03B8.3
uniprot id: Q21179
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE T02B5.4
gene id: 6239:CELE_T02B5.4
uniprot id: P92015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C36B7.1
gene id: 6239:CELE_C36B7.1
uniprot id: Q966P5
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

6239:CELE F21F3.5
gene id: 6239:CELE_F21F3.5
uniprot id: Q23022
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:9221782, PubMed:15990870, PubMed:20027209). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209). Involved in nAChR sensitivity to nicotine (PubMed:9221782, PubMed:15990870).
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
messages: Cell membrane
messages: Component of nicotinic acetylcholine receptor (PubMed:15990870, PubMed:20027209). In muscles, composed of 2 non-alpha subunits lev-1 and unc-29, and 3 alpha subunits unc-38, unc-63 and lev-8 (PubMed:15990870). In cholinergic motoneurons, composed of 2 non-alpha subunits acr-2 and acr-3, and 3 alpha subunits unc-38, unc-63 and acr-12 (PubMed:20027209).
messages: Postsynaptic cell membrane
messages: RNAi-mediated knockdown causes a resistance to nicotine-mediated paralysis.

6239:CELE ZK1320.6
gene id: 6239:CELE_ZK1320.6
uniprot id: Q09654
names: Function
names: Similarity
messages: Acts as an E3 ubiquitin-protein ligase.
messages: In the C-terminal section; belongs to the small GTPase superfamily. Arf family.

6239:CELE F55C5.11
gene id: 6239:CELE_F55C5.11
uniprot id: Q1ZXU0
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in the VA and VB motor neurons and at lower levels in the SABV neuron pair.
messages: Expression begins around the postembryonic birth of VA and VB motor neurons at the late first larval L1 stage, and is maintained throughout the life of the animals.
messages: Nucleus
messages: Probable transcription factor (PubMed:28056346). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346). Required throughout development to repress transcription by unc-3, probably acting by binding to specific promoter elements (PubMed:28056346). Represses expression of DA and DB motor neuron-specific effector genes, such as unc-129 and unc-53, in VA and VB motor neurons (PubMed:28056346).

6239:CELE R04B5.6
gene id: 6239:CELE_R04B5.6
uniprot id: Q21703
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

6239:CELE C27D6.10
gene id: 6239:CELE_C27D6.10
uniprot id: Q95ZY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srb family.
messages: Membrane

6239:CELE T10C6.12
gene id: 6239:CELE_T10C6.12
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE C03G6.8
gene id: 6239:CELE_C03G6.8
uniprot id: O01448
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y32H12A.8
gene id: 6239:CELE_Y32H12A.8
uniprot id: Q9N533
names: Similarity
messages: Belongs to the WD repeat mio family.

6239:CELE ZK1290.2
gene id: 6239:CELE_ZK1290.2
uniprot id: G5EED8
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

6239:CELE ZK697.8
gene id: 6239:CELE_ZK697.8
uniprot id: O44578
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.

6239:CELE ZK637.13
gene id: 6239:CELE_ZK637.13
uniprot id: P30627
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: By hypoxia.
messages: Cytoplasm
messages: Expressed mainly in a subset of neuronal cells and in head muscular tissue.
messages: Homodimer.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.
messages: May be a globin and may play a role in oxygen transport.

6239:CELE C11E4.2
gene id: 6239:CELE_C11E4.2
uniprot id: Q95003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutathione peroxidase family.
messages: extracellular space

6239:CELE F34D10.2
gene id: 6239:CELE_F34D10.2
uniprot id: Q7JMR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

6239:CELE W03D8.6
gene id: 6239:CELE_W03D8.6
uniprot id: A0A078BPJ4
uniprot id: A0A078BPL3
uniprot id: A0A078BS63
uniprot id: H1ZUX6
uniprot id: O45000
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F26H9.4
gene id: 6239:CELE_F26H9.4
uniprot id: P91851
names: Function
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.
messages: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate.

6239:CELE Y60A3A.13
gene id: 6239:CELE_Y60A3A.13
uniprot id: G5ECI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

6239:CELE T14G10.5
gene id: 6239:CELE_T14G10.5
uniprot id: A0A061ACR1
uniprot id: F5GUA3
uniprot id: Q22498
uniprot id: Q2XN02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

6239:CELE F10C2.4
gene id: 6239:CELE_F10C2.4
uniprot id: P90829
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-B family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer with subunits of 125 kDa and 50 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity (By similarity).
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus
messages: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity).
messages: The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.

6239:CELE F44A2.1
gene id: 6239:CELE_F44A2.1
uniprot id: H2L031
uniprot id: Q27420
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

6239:CELE C53A5.3
gene id: 6239:CELE_C53A5.3
uniprot id: O17695
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.
messages: Chromosome
messages: Component of the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465). Probable component of a NuRD-like complex, composed of at least lin-53 and hda-1 (PubMed:17075059). Interacts with lin-53 (PubMed:9875852, PubMed:17075059). Interacts with pop-1 (PubMed:11742996). Interacts with akir-1 (PubMed:30036395). Interacts with wdr-5.1 (PubMed:31602465). Interacts with cfp-1 (PubMed:31602465). Interacts with dve-1 (PubMed:32934238). Interacts with tra-4 (PubMed:17011494). May interact with nasp-1 (PubMed:17011494). Interacts with chromobox protein homolog hpl-1.
messages: Cytoplasm
messages: Expressed both maternally and zygotically.
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic lethality. RNAi-mediated knockdown results in delayed cell cycle progression (PubMed:25446273). RNAi-mediated knockdown inhibits expression of hsp-6 when adults are exposed to conditions causing mitochondrial stress (PubMed:32934238). Reduces the dve-1 protein level (PubMed:32934238).
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:25446273). Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. Required during mitochondrial stress for the activation of genes involved in the mitochondrial unfolded protein response (mtUPR), in concert with homeobox protein dve-1 (PubMed:32934238). Promotes normal hermaphrodite (XX) development, in concert with zinc finger protein tra-4 and nasp-1, perhaps as components of a complex (PubMed:17011494). Plays a role in the regulation of longevity and mtUPR-associated innate immunity (PubMed:32934238). In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide genes in response to fungal infection (PubMed:30036395).
messages: Sumoylated.
messages: Ubiquitously expressed throughout embryonic and postembryonic development.

6239:CELE B0041.6
gene id: 6239:CELE_B0041.6
uniprot id: O02058
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Homohexamer formed of two homotrimers in a head to head fashion.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity).
messages: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.

6239:CELE Y71G12B.4
gene id: 6239:CELE_Y71G12B.4
uniprot id: Q95XM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Binds 2 copper ions per subunit.
messages: Monooxygenase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Produces an unstable peptidyl(2-hydroxyglycine) intermediate. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
messages: Secreted

6239:CELE T25G3.3
gene id: 6239:CELE_T25G3.3
uniprot id: Q22792
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

6239:CELE Y39A3B.5
gene id: 6239:CELE_Y39A3B.5
uniprot id: B2L045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

6239:CELE Y38C1BA.3
gene id: 6239:CELE_Y38C1BA.3
uniprot id: Q9N527
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE C03H5.2
gene id: 6239:CELE_C03H5.2
uniprot id: O16658
names: Subcellular Location Annotation
messages: Membrane

6239:CELE M01E5.3
gene id: 6239:CELE_M01E5.3
uniprot id: A5JYZ1
uniprot id: A5JYZ2
uniprot id: O45692
names: Similarity
messages: Belongs to the UPF0561 family.

6239:CELE F20C5.4
gene id: 6239:CELE_F20C5.4
uniprot id: Q19635
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

6239:CELE Y73B6BL.29
gene id: 6239:CELE_Y73B6BL.29
uniprot id: Q95XD5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

6239:CELE ZK6.7
gene id: 6239:CELE_ZK6.7
uniprot id: O61866
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lipase involved in lipid homeostasis (PubMed:31676440). Regulates mitochondrial lipid composition, in particular cardiolipins and coenzyme Q-9 levels, in response to nutrient availability (PubMed:31676440). Does not affect global triglyceride levels in response to nutrient availability (PubMed:31676440). However, in coelomocytes, specifically promotes triglyceride catabolism and lifespan extension in response to nutrient deprivation (PubMed:31340142).
messages: Lysosome lumen
messages: RNAi-mediated knockdown impairs triglyceride catabolism and further increases lifespan extension in response to bacteria (nutrient) deprivation.
messages: Secreted
messages: Up-regulated by fasting.

6239:CELE T22D1.1
gene id: 6239:CELE_T22D1.1
uniprot id: Q9GZH0
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:KEF34 p06
gene id: 6239:KEF34_p06
uniprot id: G5EFH2
uniprot id: P24891
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE K03E5.1
gene id: 6239:CELE_K03E5.1
uniprot id: O61849
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C06G3.9
gene id: 6239:CELE_C06G3.9
uniprot id: Q17750
names: Function
names: Similarity
messages: Belongs to the UFL1 family.
messages: E3 UFM1-protein ligase that mediates ufmylation of target proteins.

6239:CELE ZK1037.9
gene id: 6239:CELE_ZK1037.9
uniprot id: O45991
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T13B5.4
gene id: 6239:CELE_T13B5.4
uniprot id: P34804
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE D1005.3
gene id: 6239:CELE_D1005.3
uniprot id: Q18909
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Cytoplasm
messages: Expressed in touch and motor neurons.
messages: In response to methylmercury.
messages: May interact with transcription factor ets-4 (PubMed:26484536). May interact (via N-terminus) with nipi-3 (PubMed:27927209). May interact (via N-terminus) with importin subunit alpha ima-3 (PubMed:31417366).
messages: Nucleus
messages: Plays a role in repressing the response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:27927200). However, is also reported to play a protective role in the response to infection by P.aeruginosa (PubMed:28662060). These differences may be due to conditions of infection or perhaps genetic background.
messages: RNAi-mediated knockdown suppresses lifespan reduction caused by infection by the Gram-negative bacterium P.aeruginosa when combined with simultaneous knockdown of nipi-3 (PubMed:27927200). Knockdown reduces survival due to infection by the Gram-negative bacterium P.aeruginosa in a valine--tRNA ligase glp-4 mutant background (PubMed:28662060).
messages: Synapse
messages: Transcription factor (By similarity). Binds to promoter regions of target genes, perhaps at the motif 5'-[AGCT]TT[AGT][TC]GAAA[ACT]-3' (PubMed:27927209). Modulates expression of genes involved in development and in stress responses, including those regulating the p38/MAPK signaling pathways such as MAPKK sek-1 and phosphatase vhp-1 (PubMed:27927209, PubMed:34407394). Involved in innate immunity (PubMed:27927200, PubMed:28662060, PubMed:34407394). Plays a role in repressing the response to infection by the Gram-negative bacterium P.aeruginosa, perhaps acting independently of the pmk-1 or pmk-3 p38/MAPK pathways (PubMed:27927200). However, also plays a protective role in the response to infection by P.aeruginosa (PubMed:28662060). Required in axonal regrowth following injury and synaptogenesis (PubMed:19737525, PubMed:31417366, PubMed:26484536). Following axon injury, in concert with transcription factor ets-4, activates expression of receptor tyrosine kinase svh-2 (PubMed:26484536). May function downstream of the Ca2+-activated p38/MAPK pathway to promote axon regeneration (PubMed:26484536). Plays a role in modulating polymerization of neuronal microtubules (PubMed:21368137). Involved in modulating lipid homeostasis (PubMed:31851340).
messages: Widely expressed in most postembryonic tissues, including epidermis, muscles, pharynx, intestine and neurons.
messages: axon

6239:CELE Y69A2AR.5
gene id: 6239:CELE_Y69A2AR.5
uniprot id: Q95XG9
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the DAMOX/DASOX family.
messages: Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine. Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups. Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid. May play a role in egg-laying events and early development.
messages: Expressed exclusively in the intestine.
messages: Expression detected initially in the gastrula-stage embryos and continuing throughout all developmental stages to adulthood.
messages: Homodimer.
messages: Mutant worms (tm3673) exhibit decreased egg-laying capacity with smaller brood size and lower hatching rates at 25 degrees Celsius. Worms do not show any change in physical appearance.
messages: Peroxisome

6239:CELE T20B12.8
gene id: 6239:CELE_T20B12.8
uniprot id: P41848
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). In embryos, may function redundantly with hmg-3 in embryos to promote cell cycle progression and development of the anterior pharynx (PubMed:30336114). In the germline, acts non-redundantly with hmg-3 to play a role in oocyte development (PubMed:30336114).
messages: Component of the FACT complex, a stable heterodimer of hmg-4 and spt-16 (Probable). The FACT complex may also include hmg-3 instead of hmg-4 (Probable).
messages: Expressed in the germline and somatic cells.
messages: Expressed throughout development (PubMed:30336114). First expressed in embryos at the 1-cell stage (PubMed:30336114).
messages: Nucleus
messages: RNAi-mediated knockdown at the L4 larval stage results in less than 10% embryonic lethality in offspring or death at the larval stage (PubMed:30336114). RNAi-mediated knockdown at the L1 larval stage results in sterile animals, which do not seem to produce mature oocytes, but that survive to adulthood (PubMed:30336114). Double RNAi-mediated knockdown at the L4 larval stage with hmg-3 results in 60% embryonic lethality in offsping (PubMed:30336114). Double RNAi-mediated knockdown with hmg-3 in embryos results in defective cell cycle initiation, duration and completion and in failed development of the anterior pharynx (PubMed:30336114).

6239:CELE C02D4.2
gene id: 6239:CELE_C02D4.2
uniprot id: G5EF04
uniprot id: H2FLI4
uniprot id: O02213
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: A loss-of-function mutation does not affect the development of AIY interneurons, or lead to egg-laying or any other behavioral defects.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. The rank order of potency is tyramine > octopamine > dopamine > serotonin > epinephrine = norepinephrine.
messages: Membrane
messages: Produced by alternative promoter usage.
messages: Produced by alternative splicing of isoform e.
messages: Produced by alternative splicing of isoform g.
messages: The different isoforms are expressed in specific, but overlapping sets of sensory, inter- and motor neurons, including AIY, AIZ and RIA interneurons. They are also expressed in pharyngeal cells, head muscles and excretory gland cells.

6239:CELE K12C11.2
gene id: 6239:CELE_K12C11.2
uniprot id: P55853
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Chromosome
messages: Cleavage of precursor form by ulp-1 is necessary for function.
messages: Covalently attached to tbx-2 (PubMed:16701625). Covalently attached to lin-1 (PubMed:15689373). Covalently attached to lin-11 (PubMed:15466489). Covalently attached to sop-2 (PubMed:15107848). Covalently attached to bet-1 (PubMed:24349540, PubMed:24285704).
messages: Cytoplasm
messages: Nucleus
messages: RNAi-mediated knockdown reduces survival (PubMed:30642431). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown causes chromosome misalignment and anaphase bridges during the first embryonic mitotic division (PubMed:25475837). RNAi-mediated knockdown results in impaired locomotion in 23% of animals (PubMed:24285704). RNAi-mediated knockdown results in ectopic expression of egl-17 in multiple vulva precursor cells and a moderate increase in phosphorylation of mpk-1 (PubMed:24349540). RNAi-mediated knockdown results in impaired activation of the mitochondrial unfolded protein response following the inhibition of respiration induced by antimycin A (PubMed:30642431). RNAi-mediated knockdown results in ectopic tbx-2 expression in seam cells and in the syncytial hypodermis (PubMed:25873636). RNAi-mediated knockdown in a bet-1 mutant background results in decreased myo-3 levels in muscles and increased transcription levels of egl-15, sur-1 and let-60 (PubMed:24285704).
messages: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837). Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625). Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540). Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704). Plays a role in male tail tip morphogenesis (PubMed:21408209). Plays a role in the mitochondrial stress response with its covalent attachment to transcription factors dve-1 and afts-1 negatively regulating the mitochondrial unfolded protein response (PubMed:30642431).
messages: centrosome
messages: spindle

6239:CELE F37A4.7
gene id: 6239:CELE_F37A4.7
uniprot id: P41885
names: Function
names: Subcellular Location Annotation
messages: Rab-3 effector.
messages: Synapse

6239:CELE C50C3.6
gene id: 6239:CELE_C50C3.6
uniprot id: P34369
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Contains a region with structural similarity to RNase H, but lacks RNase H activity.
messages: Contains a region with structural similarity to reverse transcripase, presenting the classical thumb, fingers and palm architecture, but lacks enzyme activity, since the essential metal-binding residues are not conserved.
messages: Contains a region with structural similarity to type-2 restriction endonucleases, but the residues that would bind catalytic metal ions in endonucleases are instead involved in hydrogen bonds that stabilize the protein structure.
messages: Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
messages: Nucleus
messages: Part of the U5 snRNP complex and of the U4/U6-U5 tri-snRNP complex.
messages: The MPN (JAB/Mov34) domain has structural similarity with deubiquitinating enzymes, but lacks the residues that would bind the catalytic metal ion.

6239:CELE F31E3.5
gene id: 6239:CELE_F31E3.5
uniprot id: P53013
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

6239:CELE AH6.12
gene id: 6239:CELE_AH6.12
uniprot id: Q09210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE C14B1.8
gene id: 6239:CELE_C14B1.8
uniprot id: Q17964
names: Similarity
messages: Belongs to the SIKE family.

6239:CELE F18H3.3
gene id: 6239:CELE_F18H3.3
uniprot id: Q19579
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

6239:CELE T05C3.7
gene id: 6239:CELE_T05C3.7
uniprot id: Q86B41
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE ZK377.1
gene id: 6239:CELE_ZK377.1
uniprot id: P91573
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Cell surface
messages: Expressed in 4 to 7 sheath and socket cells of the anterior sensilla.
messages: Intercellular signal essential for a variety of patterning events during development.
messages: Secreted
messages: The C-terminal domain displays an autoproteolysis activity.
messages: extracellular space

6239:CELE F57B10.1
gene id: 6239:CELE_F57B10.1
uniprot id: O44743
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Expressed in the gonadal distal tip cells (DTC) during larval stages L2, L3 and L4.
messages: Nucleus
messages: Probable transcription factor, required during migration of the gonadal distal tip cells (DTC) (PubMed:24811939). Probably regulates cell adhesion of DTCs via modulation of expression of genes involved in integrin-mediated adhesion, including tln-1, src-1, and integrin pat-2 (PubMed:24811939). Modulates expression of genes involved in protein trafficking during embryogenesis, including emo-1, sec-61, calu-1, sec-24.1, enpl-1, sar-1 and tfg-1 (PubMed:27510972).
messages: RNAi-mediated knockdown targeted to the gonadal distal tip cells (DTC) causes DTC migration defects (PubMed:24811939). Significant reduction in expression of src-1 and tln-1 in DTCs (PubMed:24811939). Causes slow growth after hatching (PubMed:27510972).

6239:CELE R07E4.4
gene id: 6239:CELE_R07E4.4
uniprot id: Q21815
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the GDA1/CD39 NTPase family.
messages: Expressed in body wall muscles.
messages: Golgi apparatus membrane
messages: In contrast to uda-1, expression is not induced by stress.
messages: Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig-17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis.

6239:CELE Y48C3A.7
gene id: 6239:CELE_Y48C3A.7
uniprot id: Q9NAG4
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Found in a complex composed of ced-3, ced-4 and mac-1 or of ced-9, ced-4 and mac-1. Within the complex, interacts with ced-4.
messages: Probably together with ced-9, plays a modest role in preventing ced-4 and caspase ced-3-mediated apoptosis.
messages: RNAi-mediated knockdown causes an arrest at the L2-L3 larval stages with few adults reaching adulthood. Abnormal presence of vacuoles in the intestine with some intestinal sections almost completely degraded. RNAi-mediated knockdown in a ced-3 (n718) or ced-4 (n1416) mutant background causes a similar arrest at the L2-L3 larval stages.

6239:CELE R08C7.3
gene id: 6239:CELE_R08C7.3
uniprot id: Q27511
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Expressed in somatic gonadal cells.
messages: May be acetylated.
messages: Monoubiquitination of Lys-124 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: RNAi-mediated knockdown results in sterility.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AV forms a heterodimer with H2B (By similarity).
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the repression of transcription factor ceh-22 (PubMed:24346701).

6239:CELE F07F6.7
gene id: 6239:CELE_F07F6.7
uniprot id: Q8WQF8
names: Similarity
messages: Belongs to the apolipoprotein L family.

6239:CELE C28H8.1
gene id: 6239:CELE_C28H8.1
uniprot id: Q09242
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals are sterile producing no oocytes, display a protruding vulva phenotype past the young adult stage of development, and have disrupted or no alae formation. Fewer seam cells in larval stages post the L1 larval stage of development and impaired seam cell differentiation with large and irregularly shaped nuclei in seam cell-derived hyp7 cells. Defective gonadal growth and proliferation whereby gonads are thin and shortened probably due to decreased mitosis, and abnormal germ cell nuclei which are irregularly shaped and enlargened. Mis-localization of the beta-catenin homolog wrm-1 in the daughter cells of seam cells following cell division with expression equal to or stronger in the anterior daughter cells as opposed to the posterior daughter cells in 50% of mutants. Aberrant asymmetric localization of the wnt signaling component pop-1 in the nuclei of Z1 and Z4 somatic gonadal precursor cells. Increased expression of anti-apoptotic factor ced-9. RNAi-mediated knockdown results in egg-laying defective and burst vulva phenotypes.
messages: Belongs to the BCL7 family.
messages: Expressed in the hypodermis from embryogenesis to adulthood.
messages: Nucleus
messages: Required for the terminal differentiation of seam cells, and the differentiation of distal tip cells important for normal somatic gonad and germ cell development. Plays a role in the Wnt signaling pathway, regulating the expression of beta-catenin homologs wrm-1, bar-1 and sys-1, and the localization of wrm-1 and the wnt signaling pathway component pop-1 during asymmetric cell division of seam cells and the Z-cell lineage of the somatic gonad, respectively. May have a pro-apoptotic role, possibly linked to the negative regulation of expression of anti-apoptotic factor ced-9.
messages: Ubiquitous.

6239:CELE W07E11.2
gene id: 6239:CELE_W07E11.2
uniprot id: Q23212
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons. Flp-3 is expressed in the IL1 and PQR neurons.
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults.
messages: FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: Secreted

6239:CELE Y75B12B.2
gene id: 6239:CELE_Y75B12B.2
uniprot id: P52015
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6239:CELE F41G3.20
gene id: 6239:CELE_F41G3.20
uniprot id: Q4TTB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE C07E3.5
gene id: 6239:CELE_C07E3.5
uniprot id: Q17788
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y54E10BL.5
gene id: 6239:CELE_Y54E10BL.5
uniprot id: Q9N3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE K01H12.1
gene id: 6239:CELE_K01H12.1
uniprot id: Q21102
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase. Acts as an electron donor to reduce the Fe-S cluster in dph1-dph2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to dph-1-dph-2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

6239:CELE T09A5.10
gene id: 6239:CELE_T09A5.10
uniprot id: P45970
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division.
messages: Interacts with gpr-1; gpr-1 forms a complex with gpr-2 and GDP-bound goa-1.
messages: cell cortex
messages: centrosome
messages: kinetochore
messages: spindle

6239:CELE C10H11.5
gene id: 6239:CELE_C10H11.5
uniprot id: P91037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE Y70C5A.4
gene id: 6239:CELE_Y70C5A.4
uniprot id: D0VWP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE T20D4.18
gene id: 6239:CELE_T20D4.18
uniprot id: P91473
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F23B12.9
gene id: 6239:CELE_F23B12.9
uniprot id: O61667
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with ced-9; the interaction results in ced-4 release from the ced-4/ced-9 complex.
messages: Mutants block programmed cell death (PubMed:9604928). In an ain-1 mutant background, enhances the proportion of animals arrested at the larval stage, with egg-laying defects and with a ruptured vulva (PubMed:25432023).
messages: Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9 (PubMed:9604928, PubMed:10688797, PubMed:15383288). Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3 (PubMed:9604928, PubMed:10688797, PubMed:15383288). Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis (PubMed:12874127). Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron during embryogenesis (PubMed:20713707). During larval development, required for the elimination of transient presynaptic components upstream of ced-9, ced-4 and ced-3 apoptotic pathway (PubMed:26074078). Together with ain-1, a component of the miRNA-induced-silencing complex (miRISC), and probably upstream of ced-3 and ced-4, regulates temporal cell fate patterning during larval development (PubMed:25432023).
messages: Synapse

6239:CELE T12E12.1
gene id: 6239:CELE_T12E12.1
uniprot id: Q22431
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBR family. Ariadne subfamily.
messages: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
messages: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBC-2/UBE2L3, and then transfers it to substrates.
messages: Nucleus

6239:CELE C04F6.4
gene id: 6239:CELE_C04F6.4
uniprot id: Q11176
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat AIP1 family.
messages: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils.
messages: cytoskeleton

6239:CELE T10H4.12
gene id: 6239:CELE_T10H4.12
uniprot id: P43507
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE ZK637.11
gene id: 6239:CELE_ZK637.11
uniprot id: P30634
names: Similarity
messages: Belongs to the MPI phosphatase family.

6239:CELE Y54G2A.23
gene id: 6239:CELE_Y54G2A.23
uniprot id: Q9N3B0
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Animals are viable, and despite a delay in growth rate, appear healthy and have a normal lifespan (PubMed:30147641). No defects in the axon formation or guidance of dopaminergic, GABAergic or serotinergic neurons (PubMed:30147641). However, there is an age-dependent decline in the number of viable dopaminergic neurons under normal growth conditions (PubMed:30147641). Up-regulation of ER stress response protein hsp-4 in the intestine, hypodermis and spermatheca (PubMed:30147641). RNAi-mediated knockdown results in up-regulation of hsp-4 in the intestine and pharyngeal epithelium (PubMed:29497057).
messages: Belongs to the ARMET family.
messages: By endoplasmic reticulum stress.
messages: Endoplasmic reticulum lumen
messages: Expressed in the intestine, spermatheca and nervous system (PubMed:30147641, PubMed:29497057). Expressed in the hypoderm (PubMed:29497057). Expressed in structures of the excretory system (PubMed:30147641). Not expressed in the male gonad (PubMed:30147641).
messages: Expressed throughout development, but expression declines with age (PubMed:30147641). Expressed in regions corresponding to intestinal cells and the body wall muscle quadrant in gastrulating embryos, and this continues throughout all larval stages and into adulthood in most tissues except gonadal cells (PubMed:30147641). In L4 stage larva, expressed in pharyngeal and vulval muscles (PubMed:30147641).
messages: Inhibits endoplasmic reticulum (ER) stress response (By similarity). Retained in the ER under normal conditions and is up-regulated and secreted by the ER in response to ER stress and hypoxia (By similarity). Following secretion by the ER, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity). Has a neuroprotective role, ensuring survival of dopaminergic neurons during normal growth (PubMed:30147641).
messages: Secreted

6239:CELE B0414.6
gene id: 6239:CELE_B0414.6
uniprot id: O01836
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
messages: Cytoplasm
messages: During germline proliferation.
messages: Interacts with csn-5. Interacts (via C-terminus) with kgb-1. Interacts with zyx-1.
messages: Probable ATP-binding RNA helicase.

6239:CELE C34C6.8
gene id: 6239:CELE_C34C6.8
uniprot id: P20270
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K06B4.8
gene id: 6239:CELE_K06B4.8
uniprot id: O45664
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K03A1.1
gene id: 6239:CELE_K03A1.1
uniprot id: K7ZUH9
uniprot id: P08898
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation is generally linked to gene activation.
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Methylation at Lys-5 is linked to gene activation and is absent from male inactive X chromosome chromatin. Methylation at Lys-10 is linked to gene repression and is enriched in male inactive X chromosome chromatin. Methylation at Lys-37 occurs on the entire length of autosomes during meiotic prophase. Trimethylation at Lys-10 and Lys-37 is specifically antagonized by jmjd-2. Dimethylation and trimethylation at Lys-28 occurs in all nuclei. The mes-2-mes-3-mes-6 complex may be responsible for Lys-28 methylation in most of the germline and in the early embryo.
messages: Nucleus
messages: Phosphorylated at Ser-11 and Ser-29 during M phase. Phosphorylation of Ser-11 requires air-2 but not air-1. Dephosphorylated by gsp-1 and/or gsp-2 during chromosome segregation.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE ZK54.2
gene id: 6239:CELE_ZK54.2
uniprot id: Q7YZT6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
messages: Catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a 2 step process.
messages: Expressed in all development stages.
messages: In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.
messages: No visible phenotype.

6239:CELE F40G9.3
gene id: 6239:CELE_F40G9.3
uniprot id: Q9TZ69
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6239:CELE Y75B8A.14
gene id: 6239:CELE_Y75B8A.14
uniprot id: Q9XW68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

6239:CELE C06G4.2
gene id: 6239:CELE_C06G4.2
uniprot id: P34308
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle (PubMed:22253611). Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death (PubMed:12410314, PubMed:22479198).
messages: Expressed in muscle and neuronal tissues (PubMed:12410314, PubMed:22479198). Expressed in the ventral and dorsal nerve cord, intestinal and hypodermal tissues (PubMed:22479198).
messages: M line
messages: RNAi-mediated knockdown results in adult muscle defects which include irregularities in sarcomeric structures, disorganized integrin attachment complexes, and increased mitochondrial fragmentation (PubMed:22253611). RNAi-mediated knockdown in integrin attachment complex component mutants unc-112 (e669su250) and unc-52 (r367) blocks the protein degradation which normally results from complex disruption (PubMed:22253611). RNAi-mediated knockdown suppresses cell death in the neurodegenerative models deg-3 (u662), gsa-1 (Q227L) and mec-4 (u231) (PubMed:12410314).
messages: sarcomere

6239:CELE C24G7.2
gene id: 6239:CELE_C24G7.2
uniprot id: P91102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

6239:CELE T20G5.5
gene id: 6239:CELE_T20G5.5
uniprot id: P34578
names: Function
names: Subunit
names: Tissue Specificity
messages: Expressed specifically in neurons including the nerve ring, ventral and dorsal nerve cord motor neurons and tail ganglia.
messages: Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1 (PubMed:22897658).
messages: Interacts (via C-terminus) with drn-1.

6239:CELE C15C6.4
gene id: 6239:CELE_C15C6.4
uniprot id: Q9XVT1
names: Function
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.

6239:CELE K02A4.2
gene id: 6239:CELE_K02A4.2
uniprot id: P54406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units, alpha, beta and gamma (By similarity). Interacts with gpb-1 and gpb-2 (PubMed:11333232).
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
messages: Predominantly expressed in the central nervous system.

6239:CELE W03D8.8
gene id: 6239:CELE_W03D8.8
uniprot id: O45003
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE C03B8.3
gene id: 6239:CELE_C03B8.3
uniprot id: Q11106
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F58H1.4
gene id: 6239:CELE_F58H1.4
uniprot id: Q21013
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of burs and pburs.
messages: Secreted

6239:CELE Y110A7A.18
gene id: 6239:CELE_Y110A7A.18
uniprot id: Q9N585
names: Similarity
messages: Belongs to the argonaute family.

6239:CELE ZC376.7
gene id: 6239:CELE_ZC376.7
uniprot id: Q23272
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR) (PubMed:22700657, PubMed:25274306, PubMed:25773600, PubMed:30642431). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity (PubMed:22700657, PubMed:25274306, PubMed:25773600). Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of chaperone and assembly factor genes (PubMed:25773600). Component of a feedback loop involving atfs-1, atgl-1 and hlh-11 (PubMed:33078707). Acts together with flp-7 to negatively regulate the expression of the transcription regulator hlh-11, to promote expression of atgl-1, and thus atgl-1-dependent fat oxidation in response to mitochondrial stress (PubMed:33078707). In addition, functions with hlh-11 to maintain lifespan (PubMed:33078707). Promotes mtDNA maintenance and propagation of deleterious mtDNA (PubMed:27135930).
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Induced by mitochondrial stress.
messages: May be desumoylated by ulp-4.
messages: Mitochondrion matrix
messages: Nucleus
messages: Prevents the up-regulation of several innate immune genes following P.aeruginosa-mediated infection (PubMed:25274306). RNAi-mediated knockdown causes a reduction in survival following P.aeruginosa-mediated infection (PubMed:25274306). Prevents the up-regulation of mitochondrial protective genes and increases the transcription of oxidative phosphorylation machinery and tricarboxylic acid cycle genes following mitochondrial stress caused by RNAi-mediated knockdown of protease spg-7 (PubMed:22700657, PubMed:25773600). Assembly of complex I and ATP synthase of the oxidative phosphorylation machinery and oxygen consumption are reduced in a spg-7 RNAi-mediated background (PubMed:25773600). RNAi-mediated knockdown reduces the levels of deleterious mtDNA that occurs in aging cells (PubMed:27135930). Protection from death following anoxia-reperfusion is lost in a spg-7 RNAi-mediated background (PubMed:27459203). RNAi-mediated knockdown does not alter atgl-1 expression (PubMed:33078707). However, RNAi-mediated knockdown increases atgl-1 expression in a hlh-11 ok2944 mutant background (PubMed:33078707). RNAi-mediated knockdown reduces the induction of hsp-60, an indicator of mitochondrial stress following overexpression of flp-7 (PubMed:33078707).
messages: Ubiquitously expressed.

6239:CELE C24B9.7
gene id: 6239:CELE_C24B9.7
uniprot id: O76435
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.

6239:CELE Y49A3A.1
gene id: 6239:CELE_Y49A3A.1
uniprot id: G5EC25
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

6239:CELE K04A8.4
gene id: 6239:CELE_K04A8.4
uniprot id: A0A0K3AXZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE C52E4.1
gene id: 6239:CELE_C52E4.1
uniprot id: P25807
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Tissue Specificity
messages: Activated by a GATA-like transcription factor.
messages: Belongs to the peptidase C1 family.
messages: Larvae and adults, but not in embryos.
messages: Larvae exhibit strong expression in gut cells and weak expression in hypodermal cells. Adults exhibit the reverse: strong expression in hypodermal cells and weaker expression in gut cells.
messages: Thiol protease. Has a role as a digestive enzyme.

6239:CELE C35C5.1
gene id: 6239:CELE_C35C5.1
uniprot id: G5EBL3
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:2759421, PubMed:10364546). Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:2759421, PubMed:10364546, PubMed:14660541, PubMed:11937488). Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes (PubMed:8939869, PubMed:8939870, PubMed:9458050, PubMed:9056777, PubMed:10364546, PubMed:14660541). May confer protection against toxicity induced by heavy metals such as arsenite (PubMed:25204677).
messages: Component of the SDC complex, which consists of sdc-1, sdc-2 and sdc-3. Within the complex, interacts with sdc-1 and sdc-3.
messages: Expressed in embryos after the 40-cell stage and in adults.
messages: Expressed in hermaphrodites (XX), but absent in males (XO) (at protein level).
messages: Results in high lethality of hermaphrodites (XX) and in masculinization of surviving XX animals (PubMed:2759421). Disrupts the X-chromosome specific localization of sdc-3, dpy-21, dpy-26, dpy-27 and mix-1 (PubMed:9056777, PubMed:8939869, PubMed:8939870, PubMed:9458050, PubMed:14660541). RNAi-mediated knockdown results in 86% viability of hermaphrodites (PubMed:23666922). RNAi-mediated knockdown results in increased sensitivity to the heavy metal arsenite (PubMed:25204677). RNAi-mediated knockdown reduces the viability of hermaphrodites to 19% in a double xol-1(y9) and sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 11% in a triple sea-1(y356), xol-1(y9) and sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 42% in a triple sea-2(y407), xol-1(y9) sex-1(y263) mutant background (PubMed:23666922). RNAi-mediated knockdown reduces the viability of hermaphrodites to 51% in a quadruple sea-1(y356), sea-2(y407), xol-1(y9) sex-1(y263) mutant background (PubMed:23666922).

6239:CELE T05G11.1
gene id: 6239:CELE_T05G11.1
uniprot id: G5EGQ2
names: Disruption Phenotype
names: Function
names: Tissue Specificity
messages: Expressed in proximal gonad.
messages: Possible transcriptional regulator (Probable). Involved in promoting segregation of chromosomes during meiosis, perhaps acting downstream of the let-60 RAS / mpk-1 MAPK signaling pathway (PubMed:17096596).
messages: Superficially wild-type, with a normal brood size, but drastic reduction in brood size when grown at a permissive temperature of 20 degrees Celsius in an mpk-1 mutant background. Double mutant mpk-1;pzf-1 shows meiotic chromosome non-disjunction, increased embryonic lethality and also an abnormal male:hermaphrodite ratio, at 23 degrees Celsius.

6239:CELE K07C5.1
gene id: 6239:CELE_K07C5.1
uniprot id: P53489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP2 subfamily.
messages: Component of the Arp2/3 complex.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
messages: cytoskeleton

6239:CELE F43G9.9
gene id: 6239:CELE_F43G9.9
uniprot id: G5EFB5
names: Similarity
messages: Belongs to the calponin family.

6239:CELE Y39A3CR.1
gene id: 6239:CELE_Y39A3CR.1
uniprot id: Q9N405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

6239:CELE T14F9.5
gene id: 6239:CELE_T14F9.5
uniprot id: Q10574
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in PVD motor neurons.
messages: Expressed in V5 postdeirid lineage cells in L2 larvae (PubMed:31386623). Expressed in the nine ray lineage Rn.a neuroblasts and their progeny, Rn.aa and Rn.ap (PubMed:11076762).
messages: Forms a heterodimer with hlh-2.
messages: Knockout results in ectopic AMsh glial cells and also ectopic amphid socket (AMso) cells, another type of glia, from a different cell lineage (PubMed:32665354). Some animals are missing dorsal, but not ventral, CEPsh glial cells (PubMed:32665354). Mean number of ectopic AMsh glial cells increases on cnd-1 or ngn-1 mutant backgrounds (PubMed:32665354).
messages: Nucleus
messages: Probable transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:11076762). Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs (PubMed:7800042). Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis (PubMed:31386623). Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:11076762). Involved in regulating glial specification, perhaps by suppressing a glial fate in different lineages during early embryogenesis (PubMed:32665354).

6239:CELE C16C10.7
gene id: 6239:CELE_C16C10.7
uniprot id: Q09463
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the RNF5 family.
messages: Cell junction
messages: Cell membrane
messages: E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix (PubMed:15210732). Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis (PubMed:20385102, PubMed:15210732). Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting (PubMed:20385102). Plays a role in the cessation of distal tip cell migration at the end of larval morphogenesis (PubMed:22285439). Acts as a negative regulator of autophagy (PubMed:23093945).
messages: Expressed in body wall muscles.
messages: Expressed in larval stages L1, L2 and L3 and in adult animals with high expression during molting (at protein level).
messages: RNAi-mediated knockdown leads to disorganized muscle dense bodies and abnormal muscle-muscle cell boundaries. Accumulation of unc-95 in the muscle cell bodies.
messages: focal adhesion

6239:CELE C26E6.12
gene id: 6239:CELE_C26E6.12
uniprot id: Q95QU5
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

6239:CELE C10C5.4
gene id: 6239:CELE_C10C5.4
uniprot id: Q17899
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

6239:CELE C30F8.2
gene id: 6239:CELE_C30F8.2
uniprot id: Q95YD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

6239:CELE T20H4.1
gene id: 6239:CELE_T20H4.1
uniprot id: A0A168H2S6
uniprot id: Q22622
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE E04F6.5
gene id: 6239:CELE_E04F6.5
uniprot id: Q19057
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

6239:CELE E04F6.14
gene id: 6239:CELE_E04F6.14
uniprot id: Q95QP1
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE F47E1.4
gene id: 6239:CELE_F47E1.4
uniprot id: Q95ZT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C16A3.5
gene id: 6239:CELE_C16A3.5
uniprot id: Q18036
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

6239:CELE F39D8.2
gene id: 6239:CELE_F39D8.2
uniprot id: Q0G825
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Expressed in the T cell, head neurons, posterior gut cells, hypodermal cells (hyp7, hyp9, and hyp10), and P blast cells (PubMed:16824957). During T cell division, expressed asymmetrically, becoming up-regulated in posterior daughter cells (PubMed:16824957).
messages: Interacts with homeobox protein ceh-20; the interaction is direct, facilitates nuclear localization of ceh-20 and may stabilize interaction of a ceh-20-nob-1 complex with DNA.
messages: Nucleus
messages: Probable transcription coregulator (PubMed:16824957). Required for asymmetric cell divisions of the T hypodermal cells, and cell fate determination, in concert with homeobox proteins nob-1 and ceh-20 (PubMed:16824957). Acts downstream of the Wnt signaling pathway, and of ceh-20 and nob-1 (PubMed:16824957).
messages: RNAi-mediated knockdown results in absence of phasmid socket cells.

6239:CELE F37H8.1
gene id: 6239:CELE_F37H8.1
uniprot id: O17862
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in FLP neurons.
messages: In the presence of polyglutamine, mislocalizes to the cytosol and loses its transcriptional regulation activity, but is able to promote protein aggregation.
messages: Nucleus
messages: Positively regulates the RNA polymerase III-associated transcription of small non-coding RNAs.

6239:CELE ZK337.5
gene id: 6239:CELE_ZK337.5
uniprot id: G5ECI1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Expressed in embryos and larva (PubMed:12385749). In L2 and L3 stage larva, expressed in the six touch receptor neurons (PubMed:12385749).
messages: Plays a role in mechanosensory transduction (touch sensitivity).
messages: RNAi-mediated knockdown results in no visible phenotype (PubMed:12385749). RNAi-mediated knockdown enhances the touch-insensitive phenotype (the inability to respond to more than two of four touches) of mec-6 u247ts mutants at 15 degrees Celsius (PubMed:12385749).

6239:CELE C24B9.14
gene id: 6239:CELE_C24B9.14
uniprot id: Q86B37
names: Caution
names: Similarity
messages: Belongs to the nematode receptor-like protein srg family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE F54F2.5
gene id: 6239:CELE_F54F2.5
uniprot id: P34450
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F18A12.8
gene id: 6239:CELE_F18A12.8
uniprot id: O16796
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M13 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Probable cell surface protease.

6239:CELE F14B8.2
gene id: 6239:CELE_F14B8.2
uniprot id: Q19443
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Defective in RNA-mediated gene silencing.
messages: Late endosome membrane
messages: Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen.
messages: Ubiquitously present in most tissues tested. Expressed in the somatic cells of intestine, muscle, neurons, somatic gonad and embryos but not in the germline (at protein level).

6239:CELE K09C8.3
gene id: 6239:CELE_K09C8.3
uniprot id: Q21388
names: Cofactor
names: Function
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.

6239:CELE JC8.14
gene id: 6239:CELE_JC8.14
uniprot id: Q2EEM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F16F9.1
gene id: 6239:CELE_F16F9.1
uniprot id: Q94184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE T21E12.4
gene id: 6239:CELE_T21E12.4
uniprot id: A0A163VTS9
uniprot id: Q19020
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein heavy chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron (PubMed:20510931). This function may involve the regulation of dynein by pct-1 and/or cdk-5 (PubMed:20510931). Involved in the formation of synapses in the dorsal region during synaptic remodeling of DD motor neurons (PubMed:21609829). Required for anterograde trafficking of dense-core vesicles in the DB motor neuron dendrites (PubMed:22699897). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795). May also play a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). May play a role in the pairing of homologous chromosomes during meiosis (PubMed:26483555).
messages: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
messages: RNAi-mediated knockdown prevents sperm-donated centrosome from leaving the posterior cortex in 1-cell embryos (PubMed:20599902). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871). RNAi-mediated knockdown in a pam-1 mutant background restores anterior-posterior polarity, par-1, par2 and par-6 asymmetric localization and pseudocleavage formation (PubMed:20599902). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038). RNAi-mediated knockdown in a fbf-2 loss of function background results in sterility and the formation of small endomitotic oocytes (PubMed:27864381).
messages: cytoskeleton

6239:CELE ZC513.2
gene id: 6239:CELE_ZC513.2
uniprot id: Q23365
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

6239:CELE F16H6.4
gene id: 6239:CELE_F16H6.4
uniprot id: A0A0K3ARY7
uniprot id: A0A0K3AUT5
names: Similarity
messages: Belongs to the peptidase C15 family.

6239:CELE ZK1053.6
gene id: 6239:CELE_ZK1053.6
uniprot id: O02340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

6239:CELE Y22F5A.6
gene id: 6239:CELE_Y22F5A.6
uniprot id: Q9XXS1
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.
messages: By heavy metal stress conditions, in response to Cu(2+).
messages: Plays a role in the stress response to heavy metals such as copper, probably in a kgb-1-dependent manner.
messages: RNAi-mediated knockdown results in partial sensitivity to Cu(2+) ions with less than 70% of animals reaching adulthood 4 days after egg laying.
messages: Weak similarity to other lysozymes and lacks the conserved active site.

6239:CELE F18C5.2
gene id: 6239:CELE_F18C5.2
uniprot id: Q19546
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).
messages: Nucleus

6239:CELE F36H9.4
gene id: 6239:CELE_F36H9.4
uniprot id: A0A0K3AXT1
uniprot id: O16620
names: Subcellular Location Annotation
messages: Secreted

6239:CELE K07C11.4
gene id: 6239:CELE_K07C11.4
uniprot id: Q21266
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

6239:CELE C18E9.4
gene id: 6239:CELE_C18E9.4
uniprot id: Q18095
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

6239:CELE Y22D7AL.15
gene id: 6239:CELE_Y22D7AL.15
uniprot id: Q965P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6239:CELE Y32H12A.4
gene id: 6239:CELE_Y32H12A.4
uniprot id: Q9N537
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

6239:CELE F23B2.5
gene id: 6239:CELE_F23B2.5
uniprot id: P41855
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor in vitro.
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: Each flp gene is expressed in a distinct set of neurons. Flp-1 is expressed in the AVA interneurons, the M5 cholinergic pharyngeal motoneurons, and the AIA, AIY, AVE, AVK, RIG and RMG neurons.
messages: Expressed at about a twofold higher level than isoform Long.
messages: Inhibits the activity of dissected pharyngeal myogenic muscle system.
messages: May be processed by convertase egl-3.
messages: Secreted
messages: Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit.

6239:CELE C08H9.3
gene id: 6239:CELE_C08H9.3
uniprot id: P52887
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

6239:CELE T13F2.11
gene id: 6239:CELE_T13F2.11
uniprot id: Q94053
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE Y73B6BL.5
gene id: 6239:CELE_Y73B6BL.5
uniprot id: A9D2P7
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed in all nuclei in the early embryo until the comma stage, and then is expressed in body wall muscle cells and pharynx in the embryo (PubMed:17716643). Expressed in muscle until the late larval stages (PubMed:17716643). In larvae, highly expressed in intestinal cells, lateral hypodermal (seam) cells, Pn.p ventral hypodermal cells, and spermatheca (PubMed:17716643). In L3 stage larvae, expressed at low levels in distal tip cells during the ventral-to-dorsal second and longitudinal third migration phases, but not expressed during the first migration phase (PubMed:17716643). In L4 stage larvae, expressed at low levels in the ventral nerve cord (PubMed:17716643).
messages: Highly expressed in intestinal cells, lateral hypodermal (seam) cells, Pn.p ventral hypodermal cells, and spermatheca (PubMed:17716643). Expressed at low levels in the ventral nerve cord (PubMed:17716643).
messages: Nucleus
messages: Together with unc-5, involved in touch neuron axon guidance (PubMed:9473333). During gonad morphogenesis, plays a role in the unc-5-/unc-6-mediated migration of distal tip cells along the body (PubMed:17716643).

6239:CELE F54C9.6
gene id: 6239:CELE_F54C9.6
uniprot id: Q20755
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE F55G1.13
gene id: 6239:CELE_F55G1.13
uniprot id: Q20852
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE R13.3
gene id: 6239:CELE_R13.3
uniprot id: Q21973
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE F20E11.6
gene id: 6239:CELE_F20E11.6
uniprot id: Q9XV86
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C10H11.3
gene id: 6239:CELE_C10H11.3
uniprot id: P91039
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

6239:CELE K06H7.8
gene id: 6239:CELE_K06H7.8
uniprot id: P34516
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

6239:CELE F35F10.1
gene id: 6239:CELE_F35F10.1
uniprot id: Q9GYT3
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE K02G10.4
gene id: 6239:CELE_K02G10.4
uniprot id: Q21156
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a ligand for the npr-22 receptor in vitro.
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Each flp gene is expressed in a distinct set of neurons (PubMed:15236235). Flp-11 is expressed in the DD, VD and DVB motor neurons, the PVC and URX interneurons, and the AUA, BAG, DA, LUA, and SAB neurons (PubMed:15236235). Also expressed in head muscle, socket or sheath cells and uterine cells (PubMed:15236235). Expressed exclusively in PHC sensory neurons in males (PubMed:15236235, PubMed:28065609).
messages: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults (PubMed:9685599). In males, highly expressed in PHC sensory neurons during the L4 larval stage (PubMed:28065609).
messages: FMRFamides and FMRFamide-like peptides are neuropeptides.
messages: Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system (PubMed:16187307). Acts as a ligand for the npr-22 receptor in vitro (PubMed:16377032).
messages: Secreted

6239:CELE Y110A2AR.3
gene id: 6239:CELE_Y110A2AR.3
uniprot id: Q9N489
names: Similarity
messages: Belongs to the NECAP family.

6239:CELE K08D10.2
gene id: 6239:CELE_K08D10.2
uniprot id: Q21324
uniprot id: U4PF47
names: Similarity
messages: Belongs to the HscB family.

6239:CELE K02B12.8
gene id: 6239:CELE_K02B12.8
uniprot id: C6KRL6
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed througout the gonad (at protein level) (PubMed:18949042). Expressed in the germline (PubMed:15340062, PubMed:29521627).
messages: High levels of embryonic lethality, but a small proportion of the surviving progeny develop beyond the L3 larval stage (PubMed:15340062, PubMed:18949042, PubMed:29521627). Of the surviving progeny, there is a high incidence of males (him phenotype) (PubMed:18949042, PubMed:29521627). Impaired meiotic recombination with no chiasma formation between homologous chromosome pairs at diplotene and diakinesis (PubMed:15340062). This is most likely due to an absence of crossover recombination (PubMed:15340062). Disrupted rad-51 localization during meiosis, whereby rad-51-positive foci are present in the gonad similarly to wild-type, however unlike in wild-type, they disappear before the end of pachytene (PubMed:15340062).
messages: Interacts with zhp-4; the interaction is required for their localization along paired chromosomes and stability, and for the formation of chiasma during meiotic recombination.
messages: Recruited co-dependently with zhp-4 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:15340062, PubMed:18949042, PubMed:29521627, PubMed:30379819). In the early stages of pachytene, in complex with zhp-4, recruited by the zhp-1-zhp-2 heterodimer to designated crossover sites along the homolog pair to stabilize other pro-crossover factors such as rmh-1, msh-5 and cosa-1 (PubMed:29521627, PubMed:30379819). This in turn facilitates crossover and promotes the formation of chiasma in each meiotic nucleus at the late pachytene stage of meiosis (PubMed:29521627, PubMed:30379819). Plays a role in the segregation of homologous chromosomes following the completion of crossovers (PubMed:18949042). Together with him-14 and msh-5 plays a role in the activation of DNA damage-dependent apoptosis at the DNA damage checkpoint in pachytene cells (PubMed:23832114).

6239:CELE F35H12.3
gene id: 6239:CELE_F35H12.3
uniprot id: P52166
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Ubiquitously expressed throughout the development and in the adult.
messages: Expressed in most neurons.
messages: Golgi apparatus membrane
messages: Homodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable). Interacts with sel-10 (PubMed:9861048).
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling (PubMed:27661254).
messages: The PAL motif is required for normal active site conformation.

6239:CELE C27D6.4
gene id: 6239:CELE_C27D6.4
uniprot id: Q4JFH9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Expression up-regulated in animals exposed to the Gram-negative bacterium P.aeruginosa PAO1 for two generations.
messages: Nucleus
messages: Transcription factor (By similarity). Plays a role in regulating the developmentally arrested larval state known as dauer, when induced by long-term exposure to the Gram-negative bacterium P.aeruginosa PAO1, but dispensable for dauer formation induced by starvation (PubMed:32963007). Involved in regulating expression of microRNA mir-243, during long-term exposure to P.aeruginosa PAO1 (PubMed:32963007).

6239:CELE C06A8.1
gene id: 6239:CELE_C06A8.1
uniprot id: Q17693
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

6239:CELE T27E4.8
gene id: 6239:CELE_T27E4.8
uniprot id: P34696
names: Induction
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.
messages: By heat stress.

6239:CELE C25G4.10
gene id: 6239:CELE_C25G4.10
uniprot id: O18023
names: Subcellular Location Annotation
messages: Cell membrane

6239:CELE F53G12.1
gene id: 6239:CELE_F53G12.1
uniprot id: O01803
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasmic granule
messages: Endosome
messages: Expressed during embryogenesis (PubMed:18385514, PubMed:20116245, PubMed:26506309). Transiently expressed during cytokinesis in embryos on the ingressing furrow and at the midbody during early abscission (PubMed:20116245). Expressed during the L4 stage and young adult stage of development (PubMed:22634595).
messages: Expressed weakly in sperm, but more predominantly in oocytes (PubMed:18472420). Expressed in the intestine (PubMed:24843160).
messages: Golgi apparatus membrane
messages: Interacts with rei-1 and rei-2. The GDP-form preferentially binds to rei-1 and rei-2.
messages: Recycling endosome membrane
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21320697, PubMed:24843160). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21320697, PubMed:24843160). Involved in regulating the meiotic maturation of oocytes (PubMed:18472420). Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization (PubMed:18765566, PubMed:26506309). Controls cortical granule localization and targets them to the plasma membrane for exocytosis (PubMed:18765566, PubMed:22992455). Acts as a major regulator of membrane delivery during cytokinesis (PubMed:18765566, PubMed:20116245, PubMed:26506309). Regulates the cytoskeleton by facilitating astral microtubule elongation and organization during metaphase to ensure proper spindle alignment and polarity in the first embryonic cell division (PubMed:18385514). Maintains normal endoplasmic reticulum morphology during metaphase (PubMed:18385514). Involved in vesicle formation and plasma membrane repair following exposure to pore forming toxins (PubMed:21320697). Regulates endocytic recycling (PubMed:24843160). May play a role in yolk receptor endocytosis in growing oocytes (PubMed:18354496, PubMed:26506309). Plays a role in the shedding of pathogen spores from intestinal cells via its involvement in spore fusion and endocytic trafficking (PubMed:24843160).
messages: Zygotic lethal (PubMed:18765566). RNAi-mediated knockdown results in a reduced meiotic maturation rate of oocytes (PubMed:18472420). Embryos are multinucleated and osmotically sensitive with permeable and therefore defective eggshells (PubMed:18765566, PubMed:18385514). During the first cell cycle, 52% of embryos fail to extrude polar bodies, 83% of embryos display no or minimal pseudocleavage and the centrosomal-nuclear complex does not migrate to the center of embryos (PubMed:18385514). Animals display mitotic spindle alignment defects whereby in 73.9% of embryos, the P0 spindle does not rotate to the anterior-posterior axis of the embryo during anaphase, but during the metaphase to anaphase transition, the movements of the spindle are more abrupt with the spindle migrating to the posterior pole and then rebounding to the anterior-posterior axis (PubMed:18385514). In 17.4% of embryos the centrosomes are unstable and the spindle is displaced further towards the posterior pole (PubMed:18385514). Impaired localization of proteins important for establishing cell polarity such as par-2, par-3, gpr-1 and gpr-2 (PubMed:18385514). Altered microtubule organization and dynamics during metaphase including a greater distance between the growing microtubule plus ends and the posterior cortex, impeded microtubule growth with fewer growing astral microtubules reaching the cortex, and a reduced microtubule nucleation rate (PubMed:18385514). Slight defect in endoplasmic reticulum morphology whereby the large endoplasmic reticulum aggregates that normally form during metaphase and persist during anaphase, form, but do not persist during anaphase and disperse (PubMed:18385514). Mild endocytosis defect with an accumulation of the yolk protein vitellogenin in the pseudocoelom (PubMed:18354496). Impaired cortical granule (secretory vesicle) localization with granules abnormally clustered around the nuclear envelope of proximal oocytes, irregulary dispersed in the cytoplasm of oocytes a…
messages: centrosome
messages: cytosol
messages: secretory vesicle
messages: spindle
messages: spindle pole body

6239:CELE Y50E8A.9
gene id: 6239:CELE_Y50E8A.9
uniprot id: Q9NAE9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

6239:CELE F22B5.1
gene id: 6239:CELE_F22B5.1
uniprot id: Q19705
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cytoplasm
messages: Expression is first detected during embryogenesis at the beginning of morphogenesis and continues in a subset of larval tissues and in adult neurons.
messages: GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.
messages: In the embryo, strongly expressed in migrating hypodermal cells. Shortly before the beginning of elongation, expressed in many developing neurons where it persists throughout adulthood. In the larva, highly expressed in migrating hypodermal cells and the uterus. Also expressed in vulva, spermatheca, sheath cells, distal tips cells and proctoderm of the male tail.
messages: Worms exhibit abnormal vulva, gonad and male tail development and disruption in embryonic proliferation. Subcellular defects include a lack of microtubule cytoskeleton and excessive chromosomes in oocyte nuclei. Many embryos show a lethal phenotype arrested at the bean stage just prior to the beginning of morphogenesis.
messages: centrosome

6239:CELE T01E8.4
gene id: 6239:CELE_T01E8.4
uniprot id: Q22071
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Expressed in several neurons in the head, tail and ventral cord, but absent in touch receptor neurons in adults (PubMed:19652181, PubMed:23527112). Expressed in GABAergic and cholinergic motor neurons (PubMed:23527112).
messages: Expressed in touch receptor neurons and several neurons in the head, tail and ventral cord during larval development.
messages: May interact with the SCF ubiquitin ligase complex component skr-1.
messages: Perikaryon
messages: Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation (PubMed:8692859, PubMed:19652181). Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons (PubMed:23527112).
messages: Temperature-sensitive phenotype with defective touch receptor neuron synaptic transmission conferring variable degrees of touch insensitivity amongst individual animals (PubMed:8692859, PubMed:19652181). Touch receptor neurons and GABAergic motor neurons have mis-localized presynaptic vesicles as indicated by aberrant expression of the protein snb-1 and distorted cell bodies (PubMed:19652181, PubMed:23527112). Reduced rate of inhibitory postsynaptic currents at the neuromuscular junctions of GABAergic motor neurons (PubMed:23527112). No effects on cholinergic synaptic transmission or snb-1 distribution in cholinergic motor neurons (PubMed:23527112). Increased rate of paralysis, in response to acetylcholine esterase inhibition by the drug Aldicarb, due to increased accumulation of acetylcholine in the extracellular fluid resulting permanent contraction of body wall muscles (PubMed:23527112). Knockout with a mec-7 heterozygous mutant, but not a null mec-7 mutant, rescues the touch sensitivity defect in the mec-15 single mutant (PubMed:19652181).

6239:CELE F41G3.19
gene id: 6239:CELE_F41G3.19
uniprot id: Q4TTB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y60A3A.18
gene id: 6239:CELE_Y60A3A.18
uniprot id: Q9U1Y9
names: Function
names: Similarity
messages: Belongs to the SKP1 family.
messages: Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development.

6239:CELE C24H11.2
gene id: 6239:CELE_C24H11.2
uniprot id: Q9XVD6
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE F10B5.7
gene id: 6239:CELE_F10B5.7
uniprot id: G5EE53
names: Similarity
messages: Belongs to the RdRP family.

6239:CELE C02F4.1
gene id: 6239:CELE_C02F4.1
uniprot id: G5EEN3
names: Similarity
messages: Belongs to the DOCK family.

6239:CELE F48G7.11
gene id: 6239:CELE_F48G7.11
uniprot id: O44593
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F07C4.8
gene id: 6239:CELE_F07C4.8
uniprot id: P91211
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y44A6D.5
gene id: 6239:CELE_Y44A6D.5
uniprot id: Q9XXD8
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

6239:CELE F52B11.1
gene id: 6239:CELE_F52B11.1
uniprot id: Q9XUE7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the SET2 complex (also known as the SET1/COMPASS complex), which contains at least set-2, swd-2.1, cfp-1, rbbp-5, wdr-5.1, dpy-30 and ash-2 (PubMed:31602465). Within the complex, interacts with wdr-5.1, ash-2 and dpy-30 (PubMed:31602465). Also interacts with the SIN3S complex, which contains at least sin-3, hda-1, athp-1 and mrg-1 (PubMed:31602465). Interacts with sin-3, hda-1 and mrg-1 (PubMed:31602465).
messages: Nucleus
messages: Transcriptional activator that exhibits a unique DNA binding specificity for CpG motifs; enriched at promoters containing the trimethylation mark on histone H3 'Lys-4' (H3K4me3) (PubMed:24653213). Forms part of the SET2 complex and interacts with the SIN3S HDAC complex at promoters (PubMed:31602465). Required for H3K4 trimethylation and plays a repressive role in the expression of heat shock and salt-inducible genes (PubMed:30941832). Required for fertility, in cooperation with class I histone deacetylases (HDACs) (PubMed:24653213, PubMed:30941832, PubMed:31602465).

6239:CELE R11G10.2
gene id: 6239:CELE_R11G10.2
uniprot id: Q21950
names: Similarity
messages: Belongs to the selenium-binding protein family.

6239:CELE F26D11.10
gene id: 6239:CELE_F26D11.10
uniprot id: A0A131MB33
uniprot id: A0A131MB60
uniprot id: A0A131MBM6
uniprot id: A0A131MBQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6239:CELE C44B9.5
gene id: 6239:CELE_C44B9.5
uniprot id: Q18606
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K07C11.1
gene id: 6239:CELE_K07C11.1
uniprot id: Q21272
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Expressed in 14 pharyngeal cells, which include nine marginal cells, the e2 epithelial cells and the pm8 muscle (PubMed:20714352). Earliest expression in marginal cells is shortly after embryonic cell division ceases, at the late-bean to early-comma stages of development (PubMed:20714352). Expression in these cells diminishes during later embryogenesis and is absent in larvae and adults (PubMed:20714352).
messages: Nucleus
messages: Transcription factor (By similarity). May play a role in pharyngeal cell differentiation (Probable). May have a protective role in response to infection by the Gram-negative bacterium Vibrio cholerae (PubMed:22675448).

6239:CELE B0240.4
gene id: 6239:CELE_B0240.4
uniprot id: Q8I4N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope.
messages: Nucleus membrane
messages: nuclear pore complex

6239:CELE F55A12.10
gene id: 6239:CELE_F55A12.10
uniprot id: Q95R14
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Chromosome
messages: Expressed in the germline.
messages: Interacts with zhp-2; the interaction is required for their chromosome association and stability.
messages: Recruited co-dependently with zhp-2 to the synaptonemal complex between homologous chromosome pairs to regulate the formation and number of crossover events between homologs during meiotic recombination (PubMed:29521627). Together with zhp-2, promotes the accumulation of pro-crossover proteins, including zhp-3 and zhp-4, at a designated crossover site along the recombination intermediate (PubMed:29521627). Limits the number of crossover sites along a recombination intermediate by restricting the association of these pro-crossover proteins with other recombination sites during late prophase (PubMed:29521627). Also, together with zhp-2, plays a role in chromosome remodeling following crossover formation to promote two successive rounds of chromosome segregation during meiosis (PubMed:29521627).

6239:CELE C46F11.6
gene id: 6239:CELE_C46F11.6
uniprot id: Q7YX48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F45E4.7
gene id: 6239:CELE_F45E4.7
uniprot id: H2KYL1
uniprot id: H2KYL2
uniprot id: Q86MG1
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE C18A3.6
gene id: 6239:CELE_C18A3.6
uniprot id: Q95QV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

6239:CELE Y73F8A.2
gene id: 6239:CELE_Y73F8A.2
uniprot id: Q9NA62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE T04A8.1
gene id: 6239:CELE_T04A8.1
uniprot id: P46568
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srg family.
messages: Membrane

6239:CELE K02G10.3
gene id: 6239:CELE_K02G10.3
uniprot id: Q95QD1
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TMEM135 family.
messages: Cytoplasmic vesicle membrane
messages: Decreased longevity, mutants living for a significantly shorter time than wild-type worms (PubMed:21151927). Reduction in fat stores and reduction in mitochondrial action potential (PubMed:21151927).
messages: Involved in fat storage.
messages: Ubiquitously expressed.
messages: Up-regulated following cold exposure and upon fasting.

6239:CELE Y102A5C.18
gene id: 6239:CELE_Y102A5C.18
uniprot id: G5EF11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

6239:CELE Y74C9A.4
gene id: 6239:CELE_Y74C9A.4
uniprot id: Q95Y41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CoREST family.
messages: May be a component of a CoREST-like complex (PubMed:26476455). May interact with chromobox protein homolog hpl-1 (PubMed:26476455).
messages: Nucleus
messages: Probable corepressor protein acting as a component of a complex that represses transcription (Probable). May play a role, as part of a CoREST-like complex, together with the chromobox protein homologs hpl-1 and hpl-2, in the formation of the vulva and in fertility (PubMed:26476455).

6239:CELE C17G1.8
gene id: 6239:CELE_C17G1.8
uniprot id: Q5WRN1
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Expressed at 100-cell embryonic stage, in the pharynx, intestine, hypodermis and M lineage (M-1 to M-16 stages) at the L1 larval stage and in somatic gonad, vulva and rectal epithelium at the L4 larval stage.
messages: RNAi-mediated knockdown in a sma-9 (cc604) mutant background restores the production of the 2 M lineage-derived coelomocytes.
messages: Regulates cell fate specification in the postembryonic mesodermal M lineage and body size, probably by positively modulating BMP-like Sma/Mab signaling at the ligand-receptor level. Promotes ventral fate specification in the M lineage, probably by positively modulating lin-12/Notch signaling.

6239:CELE Y105C5B.19
gene id: 6239:CELE_Y105C5B.19
uniprot id: Q9NAM2
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE D1044.8
gene id: 6239:CELE_D1044.8
uniprot id: P84199
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

6239:CELE C03D6.6
gene id: 6239:CELE_C03D6.6
uniprot id: Q17604
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Expressed in 1- to 100-cell stage embryos.
messages: Interacts with gsp-1 and gsp-2; the interaction is direct.
messages: Involved in sister chromatid cohesion during mitosis and meiosis (PubMed:18923084, PubMed:22927794, PubMed:30921322). In association with the gsp-2 phosphatase, it both restricts the localization and antagonizes the function of the air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment (PubMed:18923084, PubMed:22927794, PubMed:29483514, PubMed:30921322). This in turn, drives germ cell immortality (PubMed:30921322). Furthermore, may play a role in ensuring the timely assembly of the synaptonemal complex during prophase I of meiosis (PubMed:18923084, PubMed:22927794).
messages: Nucleus
messages: RNAi-mediated knockdown results in embryonic lethality in 57% of animals, and of the surviving progeny, there is a 6% increase in the number of males (Him phenotype) (PubMed:18923084). Defective sister chromatid cohesion during meiosis and mitosis (PubMed:18923084, PubMed:22927794). Mis-localized air-2 in oocytes at the diakinesis phase of prophase I in meiosis (PubMed:18923084, PubMed:22927794). Impaired meiotic DNA double-strand break repair as evidenced by increased rad-51 positive nuclei throughout late pachytene to early diplotene in gonads, and impaired number of crossover recombination events between chromatids (PubMed:22927794). Absent syp-1, a core component of the synaptonemal complex, at the pachytene stage of meiosis (PubMed:22927794). Reduced expression of the gsp-2 phosphatase (PubMed:30921322).

6239:CELE C13A2.6
gene id: 6239:CELE_C13A2.6
uniprot id: O16871
names: Similarity
messages: Belongs to the glycosyltransferase 92 family.

6239:CELE Y38C1AA.9
gene id: 6239:CELE_Y38C1AA.9
uniprot id: Q9N432
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R11A5.1
gene id: 6239:CELE_R11A5.1
uniprot id: O45718
uniprot id: O62348
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

6239:CELE Y54F10AM.1
gene id: 6239:CELE_Y54F10AM.1
uniprot id: Q9BKZ8
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F43E2.8
gene id: 6239:CELE_F43E2.8
uniprot id: P20163
uniprot id: V6CL98
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: By endoplasmic reticulum stress.
messages: Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions (PubMed:15716356). Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion (PubMed:15716356).
messages: Endoplasmic reticulum lumen
messages: RNAi-mediated knockdown prevents the formation of ER sheet-like structures during mitosis in the 1-cell embryo. ER accumulates in foci throughout mitosis and partially fails to disperse at the end of mitosis.
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition.

6239:CELE AH6.2
gene id: 6239:CELE_AH6.2
uniprot id: Q09201
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine.
messages: Belongs to the sideroflexin family.
messages: Mitochondrion inner membrane

6239:CELE F56A4.1
gene id: 6239:CELE_F56A4.1
uniprot id: Q966D9
uniprot id: Q9N5R0
names: Caution
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Metalloprotease.
messages: Secreted

6239:CELE T24H7.3
gene id: 6239:CELE_T24H7.3
uniprot id: Q22757
names: Similarity
messages: Belongs to the GSKIP family.

6239:CELE C06B8.7
gene id: 6239:CELE_C06B8.7
uniprot id: O17575
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE K02F3.4
gene id: 6239:CELE_K02F3.4
uniprot id: Q21148
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Expressed in the pharynx, as well as throughout the intestine.
messages: Induced by P. aeruginosa infection.
messages: Nucleus
messages: RNAi-mediated knockdown increases the proportion of aged worms with fragmented mitochondria from 5% to 59% and causes a 30% decrease in cellular ATP levels at day 8 in adult (PubMed:32350153). RNAi-mediated knockdown decreases survival upon infection with P.aeruginosa (PubMed:20133860, PubMed:28662060). RNAi-mediated knockdown reduces induction of expression of infection response gene, irg-1, in response to P.aeruginosa (PubMed:26876169, PubMed:20133860).
messages: Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). May act together with the bZIP transcription factor, cebp-2 (PubMed:26876169). Involved in responding to mitochondrial damage (PubMed:28662060, PubMed:32350153). Plays a role in the delay of age-associated mitochondrial fragmentation and muscle decline (PubMed:32350153). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:26876169, PubMed:28662060, PubMed:20133860). Required to prevent P.aeruginosa ToxA-mediated lethality (PubMed:22520464). Required for the activation of infection response genes irg-1 and irg-2 following P.aeruginosa infection (PubMed:20133860).

6239:CELE C31H1.5
gene id: 6239:CELE_C31H1.5
uniprot id: Q18339
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F52E4.4
gene id: 6239:CELE_F52E4.4
uniprot id: G5ED42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F13B9.8
gene id: 6239:CELE_F13B9.8
uniprot id: Q6AHP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

6239:CELE Y4C6B.5
gene id: 6239:CELE_Y4C6B.5
uniprot id: Q9UAZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE Y19D10A.16
gene id: 6239:CELE_Y19D10A.16
uniprot id: G5ECR6
names: Similarity
messages: Belongs to the aldose epimerase family.

6239:CELE T05G5.4
gene id: 6239:CELE_T05G5.4
uniprot id: P34557
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K05C4.2
gene id: 6239:CELE_K05C4.2
uniprot id: Q9XUU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane

6239:CELE R01E6.3
gene id: 6239:CELE_R01E6.3
uniprot id: Q21614
uniprot id: Q8WQD8
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

6239:CELE C15A7.1
gene id: 6239:CELE_C15A7.1
uniprot id: Q17999
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE F40G9.11
gene id: 6239:CELE_F40G9.11
uniprot id: Q9TZ70
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in non-migratory, syncytial epidermis at larval stage L1.
messages: Mitochondrion
messages: Nucleus
messages: RNAi-mediated knockdown reduces lifespan and is further reduced on a daf-2 mutant background (PubMed:24699255). RNAi-mediated knockdown causes premature onset of polyglutamine-mediated paralysis (PubMed:24699255). RNAi-mediated knockdown reduces spore levels of the microsporidian pathogen N.parisii during infection, further reduced on an mdl-1 mutant background (PubMed:27402359).
messages: Transcription factor (PubMed:17826759). Binds to the E box motif 5'-CACGTG-3', probably in a heterodimeric complex with mml-1 (PubMed:17826759). Involved in modulating longevity in response to TOR signaling, dietary restriction, the decline in protein homeostasis associated with normal aging, germline signaling and the insulin-like signaling pathway (PubMed:24699255, PubMed:27001890). Plays a role in autophagy (PubMed:27001890). Involved in regulating migration of the ray 1 precursor cells in the male tail, acting in concert with Wnt and semaphorin signaling pathways (PubMed:17826759). Regulates transcription of genes encoding extracellular matrix (ECM) components which may contribute to the substratum required for migration of the neighboring ray 1 precursor cells (PubMed:17826759). Required for resistance to oxidative stress (PubMed:24699255). Involved in promoting infection by the microsporidian pathogen N.parisii, probably acting independently of its canonical partner, mml-1 (PubMed:27402359).
messages: Widely expressed.

6239:CELE T26C11.7
gene id: 6239:CELE_T26C11.7
uniprot id: Q22812
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the CUT homeobox family.
messages: Chromosome
messages: Expressed in embryos (PubMed:17720939). First expressed in the 2 cell stage, with expression increasing at the 8-cell stage, but subsequently decreasing by the 150-cell stage and almost abolished by the 200-cell stage (PubMed:17720939).
messages: Expressed in hermaphrodite gonads.
messages: Nucleus
messages: RNAi-mediated knockdown results in viable hermaphrodites as in wild-type.
messages: Transcriptional regulator which is involved in the sex determination and X chromosome dosage compensation pathways (PubMed:23666922, PubMed:17720939). Directly binds to 5'-ATTGAT-3' sites in the promoter of sex-determining factor xol-1 to negatively regulate its expression and promote hermaphrodite development (PubMed:23666922, PubMed:17720939). Associates with condensed DNA during mitosis (PubMed:17720939).

6239:CELE W09G12.8
gene id: 6239:CELE_W09G12.8
uniprot id: O45199
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

6239:CELE Y51F10.3
gene id: 6239:CELE_Y51F10.3
uniprot id: Q8WTJ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE Y67H2A.7
gene id: 6239:CELE_Y67H2A.7
uniprot id: A0A061ACY6
uniprot id: Q95PY9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

6239:CELE F30H5.2
gene id: 6239:CELE_F30H5.2
uniprot id: Q09982
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YARP (YGGW-amide related peptide) family.
messages: May have antimicrobial activity.
messages: Secreted

6239:CELE F59E12.13
gene id: 6239:CELE_F59E12.13
uniprot id: G5EFP5
names: Activity Regulation
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Catalyzes the addition of fucose in alpha 1-3 linkage. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc-beta-1->2-Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (GnM3F6) acceptors.
messages: Expressed in larvae and adult.
messages: Golgi stack membrane
messages: Inhibited by Ni(2+) and to a lesser extent by Mn(2+) and Cu(2+).
messages: N-glycosylated.
messages: No obvious defect in N-glycan composition.
messages: Unlike other alpha-(1,3)-fucosyltransferases, appears not to require a divalent metal cation as cofactor.

6239:CELE K12C11.6
gene id: 6239:CELE_K12C11.6
uniprot id: A4V4W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6239:CELE Y2H9A.1
gene id: 6239:CELE_Y2H9A.1
uniprot id: Q9NH52
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Derepression of X-linked genes in the germline. RNAi-mediated knockdown results in sterility (PubMed:16710447). RNAi-mediated knockdown suppresses the multivulval phenotype of the lin-15A/B n765 mutant (PubMed:16507136, PubMed:16710447). RNAi-mediated knockdown at 25 degrees Celsius rescues the larval lethality phenotype of the mep-1 (q660) single mutants (PubMed:16710447).
messages: Expressed both maternally and zygotically. Expressed in all cells of early embryos. In late embryos and L1 larva, it is weakly expressed in somatic cells, while it is expressed at intermediate levels in the primordial germ cells Z2 and Z3.
messages: Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes (PubMed:12077420, PubMed:16968818). Not related to transcription elongation (PubMed:12077420, PubMed:16968818). Required for small-RNA-induced H3K27 trimethylation (PubMed:26365259). May suppress sensitivity to RNAi (PubMed:16507136). May regulate the expression of genes required for vulval development (PubMed:16507136, PubMed:16710447).
messages: In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells.
messages: Nucleus

6239:CELE F19F10.4
gene id: 6239:CELE_F19F10.4
uniprot id: O01517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE F42A9.1
gene id: 6239:CELE_F42A9.1
uniprot id: D5MCN8
uniprot id: H2KZC9
names: Function
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.
messages: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

6239:CELE T11F8.3
gene id: 6239:CELE_T11F8.3
uniprot id: O44191
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE R08D7.6
gene id: 6239:CELE_R08D7.6
uniprot id: P30645
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
messages: May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.
messages: Reduced body size and an egg-laying constitutive phenotype.

6239:CELE Y47D3A.26
gene id: 6239:CELE_Y47D3A.26
uniprot id: B2FDA8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Chromosome
messages: Component of the cohesin complex, composed of the smc-1 and smc-3 heterodimer attached via their SMC hinge domain, scc-1 which links them, and scc-3. Interacts with scc-1, smc-1 and tim-1.
messages: Involved in chromosome cohesion during cell cycle and in DNA repair (PubMed:21957461). Involved in the repair of double strand breaks during mitosis and meiosis (PubMed:21957461). Required for chromosome segregation during mitosis (PubMed:12808038). Central component of cohesin complex (PubMed:12827206, PubMed:12808038, PubMed:21957461). The cohesin complex is required for the cohesion of sister chromatids after DNA replication (PubMed:12827206). The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). Required for the localization of lab-1 to meiotic and mitotic chromosomes (PubMed:22927794).
messages: Nucleus
messages: RNAi-mediated knock-down is embryonic lethal and results in aberrant chromosome segregation during mitosis. RNAi-mediated knockdown at 20 degrees Celsius results in the mis-localization of lab-1 in germ line nuclei (PubMed:22927794).

6239:CELE R74.3
gene id: 6239:CELE_R74.3
uniprot id: G5EE07
names: Disruption Phenotype
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE) (By similarity). Plays a role in modulation of the UPR, lipid metabolism, proteostasis, and lifespan (PubMed:23791175, PubMed:31303493, PubMed:31315038. PubMed:31570707). In neurons, rescues stress resistance, increases longevity, and, drives expression of lysosomal genes in the intestine and activates the UPR in distal, non-neuronal cell types through a cell-nonautonomous mechanism (PubMed:23791175, PubMed:31303493, PubMed:31315038). In neurons or intestine, plays a role in protection against proteotoxicity, acting via positive modulation of genes involved in lysosomal function, including lipases and the fatty-acid desaturase fat-6 (PubMed:31303493, PubMed:31315038). Protection against proteotoxicity in neurons is dependent upon the transcription factor atf-6 (PubMed:31570707).
messages: Interacts with SUMO-conjugating enzyme ubc-9; the interaction is direct.
messages: Nucleus
messages: Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ire-1: upon ER stress, the emerging xbp-1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient docking to the ER membrane and translational pausing, therefore facilitating efficient ire-1-mediated xbp-1 mRNA isoform 2 production.
messages: RNAi-mediated knockdown inhibits induction of expression of the endoplasmic reticulum chaperone BiP homolog hsp-4 and heat shock protein hsp-3 during the unfolded protein response (UPR) (PubMed:11780124, PubMed:11779465). Larval development is normal, but in a pek-1 genetic background, causes arrested development at or prior to the L2 larval stage (PubMed:11779465). Abolishes crt-1 promoter activity (PubMed:24933177). Reduces lifespan, perhaps acting independently of macroautophagy (PubMed:31303493). In combination with RNAi-mediated knockdown of atf-6, causes lethality early in larval development (PubMed:16184190). Intestine-specific RNAi-mediated knockdown prevents up-regulation of several lysosomal transcripts (PubMed:31303493).
messages: Required for transcriptional regulation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) under stressed conditions, acting downstream of ire-1, and also maintaining ER homeostasis via a negative feedback loop, in parallel with ER kinase pek-1 (PubMed:11780124, PubMed:11779465, PubMed:22125500, PubMed:16184190). May also regulate Golgi protein trafficking distal to the ER (PubMed:16184190). Protects the host organism from the detrimental effects of mounting an innate immune response to microbes, such as the Gram-negative bacterium P.aeruginosa, probably by modulating the UPR (PubMed:20182512, PubMed:22125500).
messages: Sumoylated (PubMed:24933177). Sumoylation may negatively modulate the transcription of genes involved in the ER-stress-response (PubMed:24933177).

6239:CELE R02D3.5
gene id: 6239:CELE_R02D3.5
uniprot id: O44501
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

6239:CELE BE10.2
gene id: 6239:CELE_BE10.2
uniprot id: O17554
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. TMEM195 subfamily.
messages: Endoplasmic reticulum membrane
messages: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.

6239:CELE T07F10.4
gene id: 6239:CELE_T07F10.4
uniprot id: Q22316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

6239:CELE Y17G7B.18
gene id: 6239:CELE_Y17G7B.18
uniprot id: Q9U2R0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Probable RNA methyltransferase.

6239:CELE Y116A8A.2
gene id: 6239:CELE_Y116A8A.2
uniprot id: Q9U2W1
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE T12D8.10
gene id: 6239:CELE_T12D8.10
uniprot id: Q69ZI6
names: Similarity
messages: Belongs to the BolA/IbaG family.

6239:CELE Y51A2D.5
gene id: 6239:CELE_Y51A2D.5
uniprot id: Q9XXQ9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Expressed in the excretory canal cell and in pairs of amphid and sheath glia.
messages: H(+)-myo-inositol cotransporter (By similarity). Probably by promoting the transport of myo-inositol regulates intracellular osmosis in response to hyperosmotic stress (PubMed:21679696).
messages: Induced by hyperosmotic stress.
messages: Perikaryon

6239:CELE T25G3.2
gene id: 6239:CELE_T25G3.2
uniprot id: G5ECD6
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family. Class IV subfamily.
messages: Cell membrane
messages: Essential for the embryonic synthesis of chitin, a component of the eggshell.
messages: Expressed at L3-L4 larval stages and in adults.
messages: RNAi-mediated knockdown causes the production of abnormal eggs characterized by a spherical morphology, the absence of the eggshell chitin layer, increased permeability to small molecules and a failure to divide (PubMed:16098962). Loss of polar body formation and loss of egg-3 and mbk-2 cortical localization in oocytes (PubMed:17869112). RNAi-mediated knockdown causes polyspermy in 40 percent of animals and a failure to internalize egg-1 after oocyte fertilization (PubMed:20971008). Simultaneous RNAi-mediated knockdown with mat-1 prevents the formation of the eggshell chitin layer (PubMed:20971008).

6239:CELE C02B8.5
gene id: 6239:CELE_C02B8.5
uniprot id: Q11095
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

6239:CELE C28C12.8
gene id: 6239:CELE_C28C12.8
uniprot id: Q18277
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: First expressed in the gonadal leader cells, the distal tip cells (DTCs) in hermaphrodites and linker cells in males, during the early larval L2 stage (PubMed:17588558). Expression in the linker cells in males continues until larval stage L4 (PubMed:17588558). Expression in DTCs in hermaphrodites continues until adulthood (PubMed:17588558).
messages: Forms a heterodimer with helix-loop-helix protein hlh-2.
messages: Nucleus
messages: RNAi-mediated knockdown reduces expression of alpha integrin ina-1 and ADAMTS protease gon-1, and causes defects in migration of the gonadal distal tip cells (DTCs).
messages: Transcription factor which binds the E box motif 5'-GCAGGTG-3' (PubMed:17588558). Involved in migration of the gonadal leader cells; distal tip cells (DTCs) in hermaphrodites, and linker cells in males (PubMed:25982859, PubMed:17588558). Positively regulates expression of alpha integrin ina-1 and ADAMTS protease gon-1 (PubMed:25982859, PubMed:17588558).

6239:CELE K01G5.8
gene id: 6239:CELE_K01G5.8
uniprot id: G5ECC8
uniprot id: G5EDH3
names: Similarity
messages: Belongs to the FAM32 family.

6239:CELE ZK550.3
gene id: 6239:CELE_ZK550.3
uniprot id: O62512
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

6239:CELE Y45F10C.4
gene id: 6239:CELE_Y45F10C.4
uniprot id: O45944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0375 family.
messages: Secreted

6239:CELE T26H5.5
gene id: 6239:CELE_T26H5.5
uniprot id: G5EDR2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE B0336.8
gene id: 6239:CELE_B0336.8
uniprot id: Q10931
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Expressed at low levels in embryos.
messages: Most likely a component of a complex at least containing atg-5, lgg-3/ATG12, atg-16.1 and/or atg-16.2 (Probable). Interacts with atg-5 (By similarity). Interacts (via the LIR motif) with lgg-2; the interaction is direct (PubMed:26687600).
messages: Preautophagosomal structure membrane
messages: RNAi-mediated knockdown causes no visible phenotype, but animals have a reduced lifespan (PubMed:17204841). Accumulation of pgl-1-positive P granules in somatic cells (PubMed:19167332). Reduced lgg-1-positive autophagosomes in seam cells (PubMed:28758895). Delayed removal of paternal mitochondria in fertilized eggs (PubMed:22105480). RNAi-mediated knockdown reduces autophagic degradation of membrane pore-forming toxin Cry5B.
messages: The LIR motif (LC3-interacting region) is required for its interaction with lgg-2.
messages: Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin-like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane (PubMed:26687600, PubMed:28758895). Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzyme promoting atg-3-mediated lgg-1 lipidation (Probable). Involved in the degradation of P-granules by autophagy in somatic cells (PubMed:19167332). This ensures exclusive localization of the P-granules in germ cells (PubMed:19167332). Involved in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480). Involved in xenophagy, the autophagy-mediated degradation of pathogens and pathogen products, such as toxins (PubMed:27875098). Also plays a role in membrane-pore repair (PubMed:27875098).

6239:CELE ZK669.4
gene id: 6239:CELE_ZK669.4
uniprot id: Q23571
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion matrix
messages: RNAi-mediated knockdown results in reduced monomethyl branched-chain fatty acid generation and also results in larval arrest in the subsequent generation.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component (By similarity). Required for the catabolism of branched-chain amino acids and the subsequent synthesis of monomethyl branched-chain fatty acids, which are important for regulating postembryonic growth (PubMed:26683372).
messages: Ubiquitously expressed.
messages: cilium
messages: cytosol
messages: dendrite

6239:CELE R02E12.8
gene id: 6239:CELE_R02E12.8
uniprot id: Q21645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

6239:CELE F29F11.2
gene id: 6239:CELE_F29F11.2
uniprot id: G5EES5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F54C8.6
gene id: 6239:CELE_F54C8.6
uniprot id: P34444
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F08B4.5
gene id: 6239:CELE_F08B4.5
uniprot id: Q19196
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Consists of four subunits.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Nucleus

6239:CELE T10E10.5
gene id: 6239:CELE_T10E10.5
uniprot id: Q86NE4
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F44G4.8
gene id: 6239:CELE_F44G4.8
uniprot id: G5EGJ9
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
messages: Initially expressed in vulva precursor cells P5.p, P6.p and P7.p. Expression is later restricted to P5.px and P7.px and their descendants P5.pxx and P7.pxx with higher levels in the cells proximal to P6.p descendants.
messages: Interacts with pat-2.
messages: Membrane
messages: Phosphatase which may dephosphorylate receptor let-23 and thereby regulate cell fate during the development of the vulva and the excretory system (PubMed:15901674). By inhibiting let-23 signaling prevents the establishment of a primary cell fate in the descendants of vulva precursor cells P5.p and P7.p (PubMed:15901674). Similarly, may prevent duct cell fate in ABpr precursor (PubMed:15901674). Also dephosphorylates the beta-integrin subunit pat-3, probably within the alpha pat-2/beta pat-3 integrin receptor complex, which leads to down-stream effects including the negative regulation of let-23 signaling and vulval induction (PubMed:28135265). In particular, by dephosphorylating pat-3, promotes the recruitment (by unphosphorylated pat-3) of the cytoplasmic adapter protein tln-1 to the plasma membrane of secondary vulval precursor cells (PubMed:28135265). This promotes the linking of focal adhesion sites to the F-actin cytoskeleton, and also acts to restrict the mobility of the let-23 receptor on the plasma membrane of vulval cells thereby attenuating let-23 signaling (PubMed:28135265).
messages: RNAi-mediated knockdown in a lip-1 zh15 mutant background causes the descendants of P5.p and/or P7.p vulva precursor cells to adopt a mixed primary and secondary cell fate. Multivulva formation in 19 percent of animals. RNAi-mediated knockdown in a let-23 sy-1 mutant background partially restores vulva induction.

6239:CELE K03B8.1
gene id: 6239:CELE_K03B8.1
uniprot id: Q21180
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Metalloprotease.
messages: Secreted

6239:CELE F46B3.5
gene id: 6239:CELE_F46B3.5
uniprot id: Q9XV14
names: Subcellular Location Annotation
messages: Secreted

6239:CELE B0310.2
gene id: 6239:CELE_B0310.2
uniprot id: Q10938
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE F53B1.8
gene id: 6239:CELE_F53B1.8
uniprot id: X5LPS1
uniprot id: X5LX59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

6239:CELE T24H7.1
gene id: 6239:CELE_T24H7.1
uniprot id: P50093
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prohibitin family.
messages: High molecular weight complex that consist of phb-1 and phb-2.
messages: Mitochondrion inner membrane
messages: PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells (PubMed:12794069). Required for clearance of paternal mitochondria after embryonic fertilization (PubMed:28017329).

6239:CELE C10A4.8
gene id: 6239:CELE_C10A4.8
uniprot id: Q17895
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: In larva and adult, expressed in the M3 pharyngeal motor neurons, extrapharyngeal neurons in the head, the PQR tail neurons, rectal cells, vulva cells, the spermetheca-uterine valve, body wall muscle cells and neurons of the ventral nerve cord. In the embryo, expressed in pharyngeal cells, extrapharyngeal head neurons and within the tail. Expressed in body wall muscle cells during late embryonic stages. Expressed in the mother cells of the M2 and M3 pharyngeal motor neurons precursor cells at the embryonic bean stage and subsequently in the M2 and M3 cells as they are born. Expression is sustained only in the two M3 cells up to at least the 5-day-old adult. In contrast, expression gradually declines in the M2 cells beginning from the time of their birth, and is completely undetectable by the time of hatching.
messages: Nucleus
messages: RNAi-mediated knockdown results in defective formation of the distal end of the two M2 pharyngeal motor neurons.
messages: Required in the M3 pharyngeal motor neuron to guide the growth cone of the sister M2 motor neuron during axon development.

6239:CELE C48E7.9
gene id: 6239:CELE_C48E7.9
uniprot id: Q8IG65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F27E11.1
gene id: 6239:CELE_F27E11.1
uniprot id: G5EE77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

6239:CELE B0281.6
gene id: 6239:CELE_B0281.6
uniprot id: O16613
names: Similarity
messages: Belongs to the BACURD family.

6239:KEF34 p09
gene id: 6239:KEF34_p09
uniprot id: G5EFS7
uniprot id: P24888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.

6239:CELE T20G5.4
gene id: 6239:CELE_T20G5.4
uniprot id: P34577
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms chloride channels.
messages: Forms oligomers.

6239:CELE Y73C8B.4
gene id: 6239:CELE_Y73C8B.4
uniprot id: P45442
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in cells immediately adjacent to ventral mesodermal lineage (M lineage) cells, but not next to dorsal M lineage cells, beginning at the 4-M stage (PubMed:18036582). Expressed in all six vulval precursor cells (VPCs) in the early larval L3 stage, subsequently more highly expressed in P6.p while the expression in the other VPCs diminishes (PubMed:14960273, PubMed:21596897). Expressed in the anchor cell (AC) and distal tip cells (DTCs) of the somatic gonad at larval stage L3 (PubMed:21596897). Expressed in the inter labial IL2 neurons at the onset of and throughout the developmentally arrested larval state known as dauer (PubMed:18599512).
messages: Expressed in the gonad distal tip cell (DTC) of hermaphrodites.
messages: May interact with lin-12 / Notch receptor.
messages: Probable ligand for lin-12/Notch and glp-1/Notch receptors and involved in the mediation of Notch signaling (PubMed:8139658, PubMed:7607081, PubMed:18036582, PubMed:18700817, PubMed:8575327). Involved in the lin-12/Notch pathway signaling of cell fate in vulval precursor cells (VPCs) and in the postembryonic mesodermal lineage (M lineage), acting redundantly with dsl-1 and apx-1 (PubMed:14960273, PubMed:18036582). Functions in uterine cells to promote basement membrane mobility during tissue remodeling (PubMed:27661254, PubMed:8139658). Required for oocyte growth control, acting redundantly with apx-1, perhaps signaling via the glp-1/Notch pathway (PubMed:19502484). Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons (PubMed:21737278). Involved in maintaining the developmentally arrested larval state known as dauer, probably signaling in the glp-1/Notch pathway (PubMed:18599512). Required for normal sleep bout quantity and arousal thresholds during the transition from the last larval stage to adulthood in well-fed animals (PubMed:29523076).
messages: RNAi-mediated knockdown in cells of the pi uterine cell lineage results in impaired basement membrane mobility (PubMed:27661254). RNAi-mediated knockdown, on a lin-15 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate (PubMed:14960273). RNAi-mediated knockdown, when combined with knockdown of apx-1, on a dsl-1 mutant background, causes adjacent vulval precursor cells (VPCs) to adopt altered cell fate; phenotype exacerbated on double mutant lin-15;dsl-1 background (PubMed:14960273). RNAi-mediated knockdown, on a lin-12 mutant background, induces the presence of 1-2 extra mesodermal lineage (M lineage)-derived coelomocytes and the concomitant loss of sex myoblasts on the ventral side of the animal (PubMed:18036582). On an apx-1 mutant background, RNAi-mediated knockdown causes germ cells to display nuclear morphology consistent with meiotic prophase or gametogenesis in adult hermaphrodites (PubMed:19502484).
messages: The N-terminal region and DSL domain may be involved in interacting with Notch receptors.

6239:CELE F22B5.7
gene id: 6239:CELE_F22B5.7
uniprot id: G5EEM5
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TOG/XMAP215 family.
messages: Cytoplasm
messages: Expressed maternally during oogenesis. Observed during mitotic cell cycle from interphase through to early anaphase.
messages: Interacts with tac-1 to form a heterodimer.
messages: Maternal-effect embryonic lethal with meiotic and mitotic spindle positioning defects in one-cell stage embryos. RNAi-mediated knockdown results in meiosis and mitosis defects in embryos whereby embryos have one or both polar bodies absent, more than one female pronucleus and display irregular female pronuclear migration, which leads to delayed association with the male pronucleus (PubMed:16971515). RNAi-mediated knockdown results in defective mitotic spindle positioning and rotation in which spindles are established in the posterior side of the embryo and on the wrong axis (PubMed:16971515). RNAi-mediated knockdown results in a decrease in length of astral microtubules in embryos, with fewer microtubules extending from their centrosomes during cold conditions (PubMed:16971515). RNAi-mediated knockdown in a let-711 heteroallelic s2587 and it150 mutant background results in inviable embryos which do not hatch, however the astral microtubule length, polar body, female pronuclear migration and mitotic spindle defects of the single zyg-9 RNAi mutant are partially suppressed (PubMed:16971515).
messages: Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos (PubMed:16971515). Required for default nucleus positioning in oocytes (PubMed:16971515).
messages: The TOG (tumor overexpressed gene) domains are arranged in the N-terminal region with each domain composed of six (for the most part non-canonical) HEAT repeats and forming a oblong paddle-like structure. 3D-structure analysis shows the presence of additional HEAT repeats that are not detected by sequence-based prediction programs. Intra-HEAT loops are positioned along a face of the TOG domain and bind to a single alpha/beta-tubulin heterodimer. The TOG domains seem to be structurally and functionally polarized. Differential functions may range from microtubule (MT) lattice binding and/or free tubulin heterodimer binding to potentiating stable incorporation of tubulin into the MT lattice.
messages: centrosome
messages: spindle pole

6239:CELE C49F5.2
gene id: 6239:CELE_C49F5.2
uniprot id: O17679
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Broadly expressed in the nervous system, including head, body and tail neurons.
messages: Chromosome
messages: Expression increases with age.
messages: Histone methyltransferase that specifically di- and trimethylates 'Lys-9' of histone H3 (H3K9me2 and H3K9me3, respectively); involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178). May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2 (PubMed:32103178). Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178). Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178). Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178). Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
messages: Interacts with baz-2.
messages: Nucleus
messages: RNAi-mediated knockdown prevents age-related decline in the expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178). RNAi-mediated knockdown improves behavioral performance in pharyngeal pumping in aged worms (PubMed:32103178).

6239:CELE F59H6.7
gene id: 6239:CELE_F59H6.7
uniprot id: Q7Z134
names: Similarity
messages: Belongs to the cyclin family.

6239:CELE C56G7.1
gene id: 6239:CELE_C56G7.1
uniprot id: Q09510
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Arrest at the 2-fold embryonic stage which is associated with a defect in embryo elongation and failure of seam cells to elongate to a narrow morphology. No abnormalities in body wall or pharyngeal muscles and in the number of hypodermal cells.
messages: Cytoplasm
messages: Expressed at the bean stage in the lateral hypodermal seam cells and then throughout embryogenesis and into larval stages.
messages: Expressed in the spermathecal and uterine walls. Weak expression in gonadal sheath and intestinal muscle. Not detected in vulval, pharyngeal or body wall muscles.
messages: May be phosphorylated by let-502 or/and pak-1 and dephosphorylated by mel-11 to regulate its activation and myosin II-mediated contraction.
messages: Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).
messages: Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles (PubMed:19675126). Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity (PubMed:10427096).
messages: This chain binds calcium.
messages: cytoskeleton

6239:CELE T15B7.4
gene id: 6239:CELE_T15B7.4
uniprot id: O17036
names: Subunit
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE K10D6.1
gene id: 6239:CELE_K10D6.1
uniprot id: Q21420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE K07E8.6
gene id: 6239:CELE_K07E8.6
uniprot id: H2L0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

6239:CELE C35A5.5
gene id: 6239:CELE_C35A5.5
uniprot id: Q18473
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 92 family.
messages: Membrane

6239:CELE F25F2.2
gene id: 6239:CELE_F25F2.2
uniprot id: Q19319
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Broadly expressed in the nervous system starting early in development (PubMed:22442082). At the L3 larval stage, broad expression throughout the nervous system ceases, and it is specifically expressed in ventral D-type GABAergic motorneurons (PubMed:22442082).
messages: Cell membrane
messages: In larvae and adult, it is expressed in various tissues including pharyngeal muscle, hypodermis and gonad. In the nervous system it is expressed in sensory neurons and motor neurons in the ventral cord.
messages: Potential calcium-dependent cell-adhesion protein that controls axon guidance in the ventral cord.
messages: RNAi-mediated knockdown results in irregular accumulation of snb-1-positive synaptic vesicles along the axons of ventral D-type GABAergic motorneurons.
messages: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

6239:CELE F23F1.9
gene id: 6239:CELE_F23F1.9
uniprot id: Q95X83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

6239:CELE F14H12.1
gene id: 6239:CELE_F14H12.1
uniprot id: Q966K5
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F21A3.7
gene id: 6239:CELE_F21A3.7
uniprot id: G5EE87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE Y49E10.24
gene id: 6239:CELE_Y49E10.24
uniprot id: Q9XTU0
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE T22A3.4
gene id: 6239:CELE_T22A3.4
uniprot id: Q8I4F7
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
messages: Expressed in pharyngeal and body wall muscles.
messages: Histone methyltransferase (PubMed:29514099). Specifically methylates 'Lys-36' of histone H3, inducing di-methylation (PubMed:29514099). Plays a role in modulating lifespan and oxidative stress resistance, in a manner dependent upon daf-16/Forkhead box protein O and the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:29514099). Represses transcription of daf-16 isoform a, perhaps by methylating histone H3 at the daf-16 promoter, which in turn leads to recruitment of histone deacetylases and thus modulation of expression (PubMed:29514099).
messages: Muscle-specific expression increases in adults between day 3 and day 11.
messages: RNAi-mediated knockdown causes lifespan extension.

6239:CELE F25B4.1
gene id: 6239:CELE_F25B4.1
uniprot id: Q22968
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6239:CELE R03E9.3
gene id: 6239:CELE_R03E9.3
uniprot id: H2L0C4
uniprot id: Q58G79
uniprot id: Q58QG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

6239:CELE Y71G12B.25
gene id: 6239:CELE_Y71G12B.25
uniprot id: Q95XM8
uniprot id: W6RYA2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE K09A11.2
gene id: 6239:CELE_K09A11.2
uniprot id: Q27506
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE W10C8.6
gene id: 6239:CELE_W10C8.6
uniprot id: Q4W4Z6
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

6239:CELE F55C7.7
gene id: 6239:CELE_F55C7.7
uniprot id: O61528
uniprot id: Q7JNG6
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

6239:CELE F22A3.2
gene id: 6239:CELE_F22A3.2
uniprot id: Q19694
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode transthyretin-like family.
messages: Secreted

6239:CELE C03D6.8
gene id: 6239:CELE_C03D6.8
uniprot id: Q17606
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homologue, RPL24 (By similarity).
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity).
messages: nucleolus

6239:CELE C18E9.10
gene id: 6239:CELE_C18E9.10
uniprot id: G5EDD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

6239:CELE F28C6.7
gene id: 6239:CELE_F28C6.7
uniprot id: Q19869
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

6239:CELE F55A11.3
gene id: 6239:CELE_F55A11.3
uniprot id: Q20798
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
messages: Belongs to the HRD1 family.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Reduced growth rate.
messages: The RING-type zinc finger is required for E3 ligase activity.

6239:CELE Y48A6C.4
gene id: 6239:CELE_Y48A6C.4
uniprot id: Q9XWK5
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

6239:CELE C38H2.2
gene id: 6239:CELE_C38H2.2
uniprot id: Q18515
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Homodimer; disulfide-linked.
messages: Membrane
messages: Ubiquitously expressed throughout development. Present in all cells.

6239:CELE C09D8.1
gene id: 6239:CELE_C09D8.1
uniprot id: L8E6H9
uniprot id: L8E6W1
uniprot id: L8E7X5
uniprot id: Q9BMN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
messages: Both isoforms are ubiquitously expressed in early embryos. In later embryos, larvae and adults expression is highest in the nerve ring, dorsal cord, ventral cord and epithelial tissues.
messages: Cell membrane
messages: Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors.
messages: adherens junction

6239:CELE C44C3.7
gene id: 6239:CELE_C44C3.7
uniprot id: Q8IFX9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C13C4.3
gene id: 6239:CELE_C13C4.3
uniprot id: O01930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus
messages: Orphan nuclear receptor.

6239:CELE Y76A2B.1
gene id: 6239:CELE_Y76A2B.1
uniprot id: G5EDS2
uniprot id: K8ESK9
uniprot id: K8F7Z0
uniprot id: K8FE00
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

6239:CELE F45F2.3
gene id: 6239:CELE_F45F2.3
uniprot id: P62784
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y59E9AR.1
gene id: 6239:CELE_Y59E9AR.1
uniprot id: G5EBJ8
names: Function
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.

6239:CELE W09C5.8
gene id: 6239:CELE_W09C5.8
uniprot id: Q9U329
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

6239:CELE ZC412.2
gene id: 6239:CELE_ZC412.2
uniprot id: Q23310
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expressed asymmetrically in ASEL sensory neuron.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4 (PubMed:23664973, PubMed:19523832).
messages: Homodimer.
messages: The extracellular domain is required for the direct sensing of alkaline pH.
messages: The protein kinase domain is predicted to be catalytically inactive.
messages: cilium

6239:CELE F49E11.2
gene id: 6239:CELE_F49E11.2
uniprot id: Q20601
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE F58H7.3
gene id: 6239:CELE_F58H7.3
uniprot id: O61216
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE F16H9.1
gene id: 6239:CELE_F16H9.1
uniprot id: P49808
names: Disruption Phenotype
names: Function
names: PTM
names: Tissue Specificity
messages: Expressed in a subset of neurons including ventral cord and head- and tail-ganglia neurons. Also expressed in non-neuronal cells including pharyngeal and uterine muscles.
messages: May be phosphorylated and activated by egl-4.
messages: RNAi-mediated knockdown in ASH sensory neurons results in hypersensitivity to dilute quinine.
messages: Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior (PubMed:10950865). Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons (PubMed:23874221).

6239:CELE F10B5.2
gene id: 6239:CELE_F10B5.2
uniprot id: Q09305
names: Similarity
messages: Belongs to the AAR2 family.

6239:CELE Y32F6A.2
gene id: 6239:CELE_Y32F6A.2
uniprot id: O45915
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F40F12.5
gene id: 6239:CELE_F40F12.5
uniprot id: H2L265
uniprot id: H2L266
uniprot id: Q7JMS4
names: Subcellular Location Annotation
messages: centrosome
messages: perinuclear region

6239:CELE T04C9.6
gene id: 6239:CELE_T04C9.6
uniprot id: H2KZV9
names: Subcellular Location Annotation
messages: adherens junction

6239:CELE ZK353.7
gene id: 6239:CELE_ZK353.7
uniprot id: P34630
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the CutC family.
messages: Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size.
messages: Reduced copper tolerance, which results in reduced brood size and retarded body length, protruding vulva (pvl) phenotype.

6239:CELE W02B3.4
gene id: 6239:CELE_W02B3.4
uniprot id: Q09341
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Membrane

6239:CELE EEED8.5
gene id: 6239:CELE_EEED8.5
uniprot id: Q09530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
messages: Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes.
messages: Nucleus

6239:CELE C35C5.6
gene id: 6239:CELE_C35C5.6
uniprot id: Q93330
names: Similarity
messages: Belongs to the NIBP family.

6239:CELE F35B12.5
gene id: 6239:CELE_F35B12.5
uniprot id: Q20010
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with sas-6 via its coiled coil domain. Interacts (via C terminus) with let-92 (part of the PP2A complex).
messages: Present in germ cells during early oogenesis, but not during late oogenesis.
messages: Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.
messages: centriole

6239:CELE C24H12.5
gene id: 6239:CELE_C24H12.5
uniprot id: A0A0K3ARI1
uniprot id: A0A0K3AWU0
uniprot id: H1ZUV7
uniprot id: H2KYF1
uniprot id: Q95X82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

6239:CELE F26D10.11
gene id: 6239:CELE_F26D10.11
uniprot id: Q9XVU1
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F37A4.9
gene id: 6239:CELE_F37A4.9
uniprot id: P41886
names: Function
names: Subunit
messages: Interacts with cul-3.
messages: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

6239:CELE F48A11.5
gene id: 6239:CELE_F48A11.5
uniprot id: H2L056
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Causes approximately 30 percent embryonic lethality (PubMed:26842564). RNAi-mediated knockdown does not cause any visible phenotype (PubMed:20977550). Cell division at the 3-cell stage is delayed. In a cdc-48.1 (tm544) mutant background, the delay in cell cycle progression is further enhanced and DNA replication is impaired resulting in the formation of DNA repair rad-51 foci (PubMed:26842564). In addition, cdt-1 degradation and disassembly of cdc-45 and sld-5 from the chromatin during mitosis is impaired (PubMed:26842564). Simultaneous RNAi-mediated knockdown of lrr-1, causes a failure to disassemble components of the CGM helicase complex psf-1, cdc-45 and spd-5 from the chromatin resulting in their abnormal association with chromatin during mitosis (PubMed:28368371). Simultaneous RNAi-mediated knockdown of ubxn-1 and ubxn-2, causes 50 percent embryonic lethality (PubMed:20977550). The surviving hermaphrodite progeny are sterile due to a lack of sperm (PubMed:20977550). Abnormal accumulation of sex determination terminal factor tra-1 (PubMed:20977550). Germline development is normal (PubMed:20977550). In males, sperm production is normal (PubMed:20977550).
messages: Chromosome
messages: Cytoplasm
messages: Expressed in embryos (at protein level) (PubMed:17498661, PubMed:26842564). Also expressed in L4 larvae and adults (PubMed:17498661). Expressed to a lesser extent between L1 and L3 larval stages (PubMed:17498661).
messages: Expressed in the germline (at protein level) (PubMed:17498661, PubMed:20977550). Expressed in spermatocytes but not in mature sperm (at protein level) (PubMed:20977550). Expressed in the spermatheca and nerve cells (PubMed:17498661).
messages: Forms a complex composed of ubxn-3, cdc-48.1, ufd-1 and npl-4.1 (PubMed:20977550). Forms a complex composed of ubxn-3, cdc-48.1 and/or cdc-48.2 and substrate cdt-1 (PubMed:26842564). Interacts (via FPK motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus) (PubMed:20977550, PubMed:26842564). Interacts (via N-terminus) with cdt-1 and ubiquitinated protein substrates; the interaction is cdc-48-independent (PubMed:26842564). May interact with npl-4.1 (PubMed:20977550).
messages: Nucleus
messages: Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity (PubMed:20977550, PubMed:26842564, PubMed:28368371). Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1 (PubMed:20977550). During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:26842564, PubMed:28368371).
messages: perinuclear region

6239:CELE F13D11.4
gene id: 6239:CELE_F13D11.4
uniprot id: Q19391
names: Similarity
messages: Belongs to the 3-beta-HSD family.

6239:CELE W05E10.3
gene id: 6239:CELE_W05E10.3
uniprot id: Q23175
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Expressed in the posterior gonad (PubMed:11476572). Expressed in some cells in the head that are probably neurons (PubMed:30890567). Expressed in the dorsal and ventral neuron RMD pair and the inner labial neuron class IL1 (PubMed:32814896). Not expressed in BAG neurons (PubMed:30890567).
messages: Expression starts during embryonic gastrulation and persists through to adults (PubMed:11476572). Expressed in neuronal precursor cells during embryogenesis (PubMed:11476572). Upon hatching, expression is also seen in sheath/spermatheca precursor cells and later in gonadal sheath cells (PubMed:11476572). Expressed in head hypodermal cells (hyp3, hyp4, hyp5 and hyp6) in larvae (PubMed:11476572).
messages: Interacts with gmn-1.
messages: Nucleus
messages: RNAi-mediated knockdown in hermaphrodite adults causes embryonic and larval lethality and head morphogenesis defects in L1 and L2 larval stages of offspring.
messages: Transcription factor which binds a motif with the core sequence 5'-GTATCA-3' (PubMed:30890567). Plays a role in head morphogenesis (PubMed:11476572). Involved in embryonic development (PubMed:32814896). Required for cell specification of the RIA interneurons (PubMed:32814896). May cooperate with the transcription factor vab-3 and phosphatase eya-1 to repress transcription factor ets-5 expression in non BAG neuronal cells (PubMed:30890567).

6239:CELE W01C8.6
gene id: 6239:CELE_W01C8.6
uniprot id: Q9GNP0
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F26D2.9
gene id: 6239:CELE_F26D2.9
uniprot id: Q9XV63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE C32F10.5
gene id: 6239:CELE_C32F10.5
uniprot id: O01683
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to double-stranded DNA (By similarity). In embryos, may function redundantly with hmg-4 to promote cell cycle progression and development of the anterior pharynx (PubMed:30336114). In the germline, acts non-redundantly with hmg-4 to play a role in oocyte development (PubMed:30336114).
messages: Component of the FACT complex, a stable heterodimer of hmg-3 and spt-16 (Probable). The FACT complex may also include hmg-4 instead of hmg-3 (Probable).
messages: Expressed in the germline.
messages: Expressed throughout development (PubMed:30336114). First expressed in embryos at the 1-cell stage, but, in contrast to hmg-4, expression begins to decrease in somatic cells from the 8E stage until the 2-fold stage (PubMed:30336114). However, expression in the germline persists throughout the larval and adult stages (PubMed:30336114).
messages: Nucleus
messages: RNAi-mediated knockdown at the L4 larval stage results in less than 10% embryonic lethality in offspring and surviving adults are sterile (PubMed:30336114). Double RNAi-mediated knockdown with hmg-4 at the L4 larval stage results in 60% embryonic lethality in offspring (PubMed:30336114). Double RNAi-mediated knockdown with hmg-4 in embryos results in defective cell cycle initiation, duration and completion and in failed development of the anterior pharynx (PubMed:30336114).

6239:CELE Y71A12B.1
gene id: 6239:CELE_Y71A12B.1
uniprot id: I2HAF9
uniprot id: Q9NEN6
names: Function
names: PTM
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.
messages: Component of the 40S small ribosomal subunit (By similarity). Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Negatively regulates lifespan (PubMed:23879233).
messages: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes.

6239:CELE C14F5.5
gene id: 6239:CELE_C14F5.5
uniprot id: P29355
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23 (PubMed:1372395, PubMed:16547100). Involved in sex myoblast migration (PubMed:1372395, PubMed:9073451). Negatively regulates fluid homeostasis probably downstream of egl-15 (PubMed:1372395, PubMed:11689700). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl-15 (PubMed:16495308). Involved in cytoskeleton dynamics and is recruited by mig-13 to the leading edge of Q neuroblasts and their descendants to signal downstream to activate the wsp-1 pathway and direct migration along the anteroposterior body axis during larval development (PubMed:27780040). Involved in let-23-mediated regulation of fertility independently of let-60/Ras (PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870). May play a role in oocyte development upstream of let-60/Ras and the MAP kinase pathway (PubMed:12169634).
messages: Belongs to the GRB2/sem-5/DRK family.
messages: Cell membrane
messages: Expressed in body wall muscles, pharynx, intestine and hypodermis.
messages: Interacts (probably via SH3 domain 2) with soc-1 (via C-terminus) (PubMed:16547100). Interacts with mig-2 (active GTP-bound form) and wsp-1 (PubMed:27780040). Interacts with mig-13; the interaction is direct (PubMed:27780040).
messages: RNAi-mediated knockdown or RNAi-mediated knockdown in body wall muscles causes ectopic membrane extensions from body wall muscles.

6239:CELE F54E12.5
gene id: 6239:CELE_F54E12.5
uniprot id: J7S164
uniprot id: J7SA65
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE Y41D4A.4
gene id: 6239:CELE_Y41D4A.4
uniprot id: Q95Y24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

6239:CELE BE0003N10.1
gene id: 6239:CELE_BE0003N10.1
uniprot id: Q965N3
names: Similarity
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.

6239:CELE F01G10.8
gene id: 6239:CELE_F01G10.8
uniprot id: F5GUE5
names: Developmental Stage
names: Function
names: Subunit
messages: Interacts with R-SMAD daf-8 and co-SMAD daf-3 (PubMed:20081192). Interacts with daf-3 in a daf-8 dependent manner (PubMed:20081192).
messages: Probably an atypical receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta-like daf-7 signaling (PubMed:10625546). Plays a role in TGF-beta-like daf-7 signaling in regulating entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions; partially redundant with R-SMAD daf-8 (PubMed:10625546, PubMed:20081192).
messages: Widely expressed in all stages from the embryo to the adult in a complex and dynamic pattern (PubMed:10625546). In L1 and L2 stage larvae, expressed in intestinal cells, lateral hypodermal cells, the anal sphincter muscle, phasmid sheath cells, neurons in the lateral ganglia, and the excretory duct cell (PubMed:10625546).

6239:CELE Y43C5A.6
gene id: 6239:CELE_Y43C5A.6
uniprot id: G5EGG8
uniprot id: L8E822
uniprot id: Q95Q25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.
messages: Nucleus

6239:CELE C36C5.6
gene id: 6239:CELE_C36C5.6
uniprot id: Q8ITZ7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE R151.5
gene id: 6239:CELE_R151.5
uniprot id: P98060
names: Cofactor
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Binds 1 zinc ion per subunit.
messages: Expressed in hypodermis, rectal and vulval epithelial cells and amphid socket cells.
messages: Expression begins at the 2-fold embryonic stage and continues throughout larval development and adulthood. In larvae, expressed in the hypodermis but not in seam cells.
messages: Metalloprotease which cleaves the carboxyl terminus of procollagens, such as sqt-3, to mature collagens (By similarity). Involved in cuticular collagen maturation (PubMed:15579684).
messages: RNAi-mediated knockdown causes embryonic lethality in 5 percent of the progeny.
messages: Secreted

6239:CELE T21G5.5
gene id: 6239:CELE_T21G5.5
uniprot id: G5EFF1
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Defective alternative splicing of the unc-60 gene which results in decreased expression of the muscle-specific isoform of unc-60 (PubMed:23071450). Double knockout with isoform c of unc-60 rescues the motility and actin filament disorganization defects in the single unc-60 isoform c mutant (PubMed:23071450). RNAi-mediated knockdown results animals that are viable throughout embryonic and larval development, and furthermore, results in defective alternative splicing of the let-2 gene, whereby transcripts containing exon 10 are not formed in larvae and so the muscle-specific isoform of let-2 is not expressed in body wall muscles (PubMed:18230701). RNAi-mediated knockdown results in abnormal ectopic expression of the non-muscle-specific isoform b of unc-60 in body wall muscles (PubMed:23071450).
messages: Expressed during embryonic development.
messages: Interacts with sup-12; in the presence of RNA, but with weak affinity in the absence of RNA.
messages: Isoform b: Expressed in the hypodermis and pharyngeal muscles (PubMed:18230701). Isoform c: Expressed in body wall muscles and phayngeal muscles (PubMed:18230701, PubMed:23071450).
messages: Nucleus
messages: RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)-UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing (PubMed:18230701, PubMed:20573244, PubMed:23071450). Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons during pre-mRNA maturation (PubMed:18230701, PubMed:23071450). Involved in muscle-specific gene expression regulating the alternative splicing of genes such as let-2 and unc-60 to ensure that their respective isoforms are expressed in muscle (PubMed:18230701, PubMed:23071450). Promotes the removal of intron 10 from let-2 pre-mRNA to allow for the exclusive expression of the muscle-specific let-2 isoform (as opposed to the non-muscle-specific isoform expressed in embryos) in body wall muscles during late larval and adult stages of development (PubMed:18230701). Binds cooperatively with RNA-binding protein sup-12 to intron 1A of the unc-60 pre-mRNA to promote alternative splicing and expression of the muscle specific isoform of unc-60 (PubMed:23071450).
messages: The KH domain and the Qua2 region are involved in RNA binding.

6239:CELE Y52B11A.2
gene id: 6239:CELE_Y52B11A.2
uniprot id: Q9XWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPACT family.
messages: Cytoplasm
messages: Interacts with gcn-1; prevents the interaction of gcn-1 with gcn-2 and inhibits gcn-2 kinase activity. Interaction with rpl-39; this interaction occurs in a gcn-1-independent manner. Associates with ribosomes; this interaction occurs in a gcn-1-independent manner. Associates with actin; this interaction occurs in a gcn-1-independent manner.
messages: Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.

6239:CELE H04J21.3
gene id: 6239:CELE_H04J21.3
uniprot id: O61208
uniprot id: Q8ITY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

6239:CELE T06G6.2
gene id: 6239:CELE_T06G6.2
uniprot id: O62368
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F08F3.7
gene id: 6239:CELE_F08F3.7
uniprot id: Q27531
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE F40F11.1
gene id: 6239:CELE_F40F11.1
uniprot id: Q20206
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

6239:CELE C33B4.3
gene id: 6239:CELE_C33B4.3
uniprot id: B7WN72
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Animals are viable, but produce a reduced brood size, have a prolonged defecation cycle and a reduced pharyngeal pumping rate as compared to wild-type (PubMed:21191812). Reduced male fertility which may be due to irregular male mating behavior and defective sperm function (PubMed:21191812). Reduced cell surface abundance of the L-type egl-19 calcium channel in body wall muscles, which results in a 20% decrease in Ca(2+) current density (PubMed:28477407). In response to the nicotinic acetylcholine agonist levamisole, there is reduced expression of genes such as gem-4 (PubMed:28477407). Irregular postsynaptic transmission at neuromuscular junctions characterized by larger stimulus-evoked excitatory postsynaptic currents as compared to wild-type (PubMed:28477407). RNAi-mediated knockdown results in viable animals with no visible phenotype (PubMed:15013747). However, there is a slight reduction in brood size, but there are no visible defects in terms of embryonic viability, growth or morphology in their resulting progeny (PubMed:15013747). RNAi-mediated knockdown in an itr-1(sa73) loss of function mutant background results in a longer defecation cycle as compared to the itr-1 single mutant (PubMed:15013747).
messages: Belongs to the SHANK family.
messages: Cytoplasmic vesicle
messages: Expressed in the pharynx, pharyngeal-intestinal valve, intestine, rectal epithelial cells, tail neurons, nerve cord and sperm.
messages: Expressed throughout development from embryos to adults. Highly expressed in the nerve cord of embryos. Expressed in vulval epithelial cells of L4 stage hermaphrodites.
messages: In contrast to the mammalian Shank proteins, does not contain a SH3 domain.
messages: Interacts (via PDZ domain) with egl-19 (via C-terminus).
messages: Postsynaptic density
messages: Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions (PubMed:28477407). Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density (PubMed:28477407). The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4 (PubMed:28477407). Plays a role in the regulation of the defecation cycle, and this may be in association with the inositol trisphosphate (IP3) receptor itr-1, which in turn mediates periodic calcium release and muscle contractions (PubMed:15013747, PubMed:21191812). Required for normal fertility and pharyngeal pumping (PubMed:21191812).
messages: pseudopodium

6239:CELE C17C3.3
gene id: 6239:CELE_C17C3.3
uniprot id: Q18061
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

6239:CELE T21B10.1
gene id: 6239:CELE_T21B10.1
uniprot id: Q22623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

6239:CELE F45F2.1
gene id: 6239:CELE_F45F2.1
uniprot id: Q22980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

6239:CELE F48G7.5
gene id: 6239:CELE_F48G7.5
uniprot id: O44585
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T05G5.10
gene id: 6239:CELE_T05G5.10
uniprot id: G1K0V8
uniprot id: P34563
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Expressed specifically in the germline in the distal region of gonads where germ cells actively proliferate.
messages: Lys-54 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Present at late larval stages and adults.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation (By similarity). Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

6239:CELE F56B3.6
gene id: 6239:CELE_F56B3.6
uniprot id: O45108
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6239:CELE Y24F12A.2
gene id: 6239:CELE_Y24F12A.2
uniprot id: A0A061ACG4
uniprot id: G5EGB3
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

6239:CELE C25A8.5
gene id: 6239:CELE_C25A8.5
uniprot id: Q18142
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6239:CELE F46F2.2
gene id: 6239:CELE_F46F2.2
uniprot id: Q20471
names: Activity Regulation
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
messages: Constant expression throughout development (PubMed:15691769, PubMed:29880558). However, expression decreases prior to the L2 larval stage, increases at the beginning of the L3 larval stage, and then decreases and plateaus from the mid L3 larval stage onwards (PubMed:31910362, PubMed:29880558). In the nervous system, expressed as dim speckles in developing DD motor neurons from the 3-fold stage of embryogenesis, then expression is dim in neurons of L1 stage larvae (PubMed:31910362). At the L2 larval stage, it is highly expressed in epidermal cells and motor neurons (PubMed:31910362). At the L4 laravl stage, it is expressed in all cell types and in the spermatheca (PubMed:31910362).
messages: Cytoplasm
messages: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms (By similarity). Casein kinases are operationally defined by their preferential utilization of acidic proteins (By similarity). Positively regulates the expression of components of the heterochronic pathway, which regulate developmental timing, such as the transcriptional repressor lin-42 and microRNAs such as let-7 (PubMed:29880558). Negatively regulates cell cycle exit and cell fusion to prevent the premature differentiation of hypodermal seam cells into adult cells (PubMed:15691769). Plays a role in regulating axon branching and subsequently, the maturation of the nervous system, most likely by preventing the premature termination of transcripts for proteins such as Ankyrin/unc-44, which are required for maintaining the nervous system (PubMed:31910362). May phosphorylate ssup-72 to promote nervous system maturation (Probable).
messages: Exhibits substrate-dependent heparin activation.
messages: Expressed throughout development.
messages: Expressed throughout larval development and into the adult stage in both hypodermal seam cells and the hermaphrodite specific neuron.
messages: Highly expressed throughout development.
messages: Monomer.
messages: Nucleus
messages: RNAi-mediated knockdown results in precocious seam cell fusion and the early exit of seam cell from the cell cycle during the L4 larval stage (PubMed:15691769). RNAi-mediated knockdown does not impair alae formation (PubMed:15691769). RNAi-mediated knockdown results in a squat body statue, referred to as a dumpy phenotype, and rescues the incomplete alae formation defect in the lin-42 (n1089) mutant (PubMed:29880558). RNAi-mediated knockdown increases the survival rate and partially restores alae formation of let-7 n2853 mutants at 20 dgrees Celsius (PubMed:15691769). RNAi-mediated knockdown rescues the lethal bursting phenotype that occurs after the L4 stage molt in the let-7(n2853) mutant at 25 degrees Celsius (PubMed:29880558).
messages: Weakly expressed throughout development.
messages: adherens junction
messages: centromere

6239:CELE JC8.7
gene id: 6239:CELE_JC8.7
uniprot id: D3YT79
uniprot id: O62291
names: Similarity
messages: Belongs to the HPF1 family.

6239:CELE M142.4
gene id: 6239:CELE_M142.4
uniprot id: Q93899
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the even-skipped homeobox family.
messages: Embryo, L1 and L2 larvae.
messages: Nucleus
messages: Transcription factor (PubMed:28056346). Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346). Probably acts by binding to specific promoter elements (PubMed:28056346). Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression (PubMed:8654927).

6239:CELE F10G7.2
gene id: 6239:CELE_F10G7.2
uniprot id: Q19328
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

6239:CELE R08F11.1
gene id: 6239:CELE_R08F11.1
uniprot id: O01893
names: Function
names: Similarity
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

6239:CELE T06E4.6
gene id: 6239:CELE_T06E4.6
uniprot id: Q22260
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE F36H1.9
gene id: 6239:CELE_F36H1.9
uniprot id: Q7YTM8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Constitutively expressed. Not regulated by heme level.
messages: Heme transporter.
messages: Membrane

6239:CELE Y110A2AL.14
gene id: 6239:CELE_Y110A2AL.14
uniprot id: Q9N491
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
messages: Golgi apparatus membrane
messages: Worms are infertile because of the failure of the progeny of homozygous mutants to initiate cytokinesis and because of the failure to form an extracellular space between the egg and the eggshell.

6239:CELE Y45G5AM.2
gene id: 6239:CELE_Y45G5AM.2
uniprot id: Q9GUI6
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24B family.
messages: Expressed in germ cells of L4 larvae (PubMed:33231880). Expressed at low levels in the pachytene stage of the meiotic region of L4 larvae (PubMed:33231880).
messages: May interact with pid-2, app-1 and prmt-5.
messages: P-body
messages: Together with pid-4, it is involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33231880). Together with pid-4, it is required for the biogenesis of secondary and tertiary 22G-siRNAs (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). Together with pid-4, plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33231880). Together with pid-4, plays a role in the formation of liquid-like condensates in the cytoplasm called Z granules (PubMed:33231880).
messages: perinuclear region

6239:CELE C10G8.5
gene id: 6239:CELE_C10G8.5
uniprot id: H2KYP2
uniprot id: H2KYP3
uniprot id: H2KYP4
uniprot id: Q8I7I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

6239:CELE T19C9.10
gene id: 6239:CELE_T19C9.10
uniprot id: D3YT90
names: Similarity
messages: Belongs to the helicase family.

6239:CELE B0410.2
gene id: 6239:CELE_B0410.2
uniprot id: H2KY90
uniprot id: Q95ZZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

6239:CELE Y71H9A.1
gene id: 6239:CELE_Y71H9A.1
uniprot id: G5EBQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE K06C4.3
gene id: 6239:CELE_K06C4.3
uniprot id: P09588
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitination of Lys-121 gives a specific tag for epigenetic transcriptional repression.
messages: Nucleus
messages: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6239:CELE ZK970.1
gene id: 6239:CELE_ZK970.1
uniprot id: G5ED52
uniprot id: G5EDC4
names: Similarity
messages: Belongs to the peptidase M13 family.

6239:CELE F39C12.4
gene id: 6239:CELE_F39C12.4
uniprot id: Q4R128
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the vasopressin/oxytocin family.
messages: Detected in thermosensory AFD neurons, neurosecretory NSM cells, AVK interneurons, pharyngeal neuron M5, and the mechanosensory DVA neuron (PubMed:23112336, PubMed:23112335). Detected in male-specific CP motor neurons (PubMed:23112335).
messages: Ligand for the G-protein coupled receptor ntr-1 (PubMed:23112336, PubMed:23112335). Plays a role in gustatory associative learning (PubMed:23112336). Also plays a role in male mating behavior (PubMed:23112335).
messages: Secreted
messages: Viable and fertile (PubMed:23112336). Gustatory associative learning in response to salt cues is disrupted (PubMed:23112336). Males have reduced reproductive success, due to a range of aberrant mating behaviors (PubMed:23112335).

6239:CELE H23N18.2
gene id: 6239:CELE_H23N18.2
uniprot id: Q9TXZ5
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T28F3.9
gene id: 6239:CELE_T28F3.9
uniprot id: G5EBQ5
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6239:CELE F10C1.2
gene id: 6239:CELE_F10C1.2
uniprot id: Q19289
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2.
messages: Expressed in epidermal cells. Expressed in amphid sensory neurons, the excretory cells, the vulva, the uterus, the rectum and some neurons of the tail. Isoform a and isoform b display a similar pattern of expression. Isoform a is predominant in pharyngeal tonofilaments.
messages: Forms some heteromeric filaments with ifa-1, ifa-2, ifa-3 and probably ifa-4.
messages: RNAi-mediated knockdown results in 79% embryonic lethality and 19% larval lethality. Abnormal localization of epidermal structural protein pat-12 during embryogenesis.

6239:CELE C39E9.14
gene id: 6239:CELE_C39E9.14
uniprot id: G5ECK7
uniprot id: G5ED34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

6239:CELE F48C1.7
gene id: 6239:CELE_F48C1.7
uniprot id: P54217
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Expressed during spermatogenesis.
messages: Expressed in mature sperm.
messages: Paternally sperm-supplied factor required for embryogenesis (PubMed:8565851, PubMed:20971008). Plays a role in preventing polyspermy possibly by promoting the formation of a continuous and cohesive eggshell chitin layer (PubMed:20971008).
messages: Worms fail to complete meiosis, form a weak eggshell, fail to orient properly the first mitotic spindle and fail to undergo cytokinesis.
messages: perinuclear region

6239:CELE K11D12.5
gene id: 6239:CELE_K11D12.5
uniprot id: O44620
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

6239:CELE F17A2.10
gene id: 6239:CELE_F17A2.10
uniprot id: Q19508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE C05B5.8
gene id: 6239:CELE_C05B5.8
uniprot id: Q86DA7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F07C6.1
gene id: 6239:CELE_F07C6.1
uniprot id: Q19157
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed in neurons and intestine.
messages: Nucleus

6239:CELE Y39B6A.47
gene id: 6239:CELE_Y39B6A.47
uniprot id: Q9NEV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F16B3.1
gene id: 6239:CELE_F16B3.1
uniprot id: O44164
names: Subcellular Location Annotation
messages: Membrane

6239:CELE B0464.2
gene id: 6239:CELE_B0464.2
uniprot id: Q03560
names: Disruption Phenotype
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the PAF1 complex which consists of at least cdc-73, ctr-9, leo-1, pafo-1 and rtfo-1.
messages: Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification (By similarity). Ctr-9 is required for epidermal microtubule organization during morphogenesis (PubMed:24721716).
messages: Nucleus
messages: RNAi-mediated knock-down is mostly embryonic lethal. Embryogenesis proceeds more slowly, with embryos displaying defects in the positioning and shape of epidermal cells. Randomly orientated microtubules are present in epidermal cells during the epidermal elongation process. F-actin accumulation is visible at the leading edge during ventral closure and circumferential actin bundles are present in epidermal cells. Decreased expression of pafo-1, increased cytoplasmic expression of leo-1 and increased nuclear expression of rtfo-1.

6239:CELE C14A4.2
gene id: 6239:CELE_C14A4.2
uniprot id: G5EFC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

6239:CELE C56A3.7
gene id: 6239:CELE_C56A3.7
uniprot id: Q18879
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Apical cell membrane
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Defective in the apical uptake of lipid and protein trafficking. Reduced brood size thought to be due to attenuated nutrient supply.
messages: Expressed in intracellular bodies in intestinal cells.
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying.
messages: caveola

6239:CELE Y51H4A.15
gene id: 6239:CELE_Y51H4A.15
uniprot id: Q2HQJ8
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

6239:CELE T19H12.11
gene id: 6239:CELE_T19H12.11
uniprot id: Q3S1L2
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F29F11.4
gene id: 6239:CELE_F29F11.4
uniprot id: Q19907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6239:CELE F42A9.4
gene id: 6239:CELE_F42A9.4
uniprot id: Q20315
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE C08F11.11
gene id: 6239:CELE_C08F11.11
uniprot id: O62053
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0375 family.
messages: Secreted

6239:CELE ZK1128.7
gene id: 6239:CELE_ZK1128.7
uniprot id: G5EF99
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6239:CELE T14G11.3
gene id: 6239:CELE_T14G11.3
uniprot id: Q22505
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Cytoplasm
messages: Egg-laying defects, defective oogenesis in 30% of mutants, reduced brood size and increased resistance to oxidative stress inducer paraquat (PubMed:20578245). Abnormal mitochondrial morphology with mitochondria appearing larger and as localized swellings and tubular extensions (PubMed:20578245, PubMed:21248201). Mitochondria also have elongated and curved cristae that are stacked with a reduced number of junctions (PubMed:20578245, PubMed:21248201). Double knockout with immt-2 results in a more reduced brood size and enhanced resistance to paraquat-induced oxidative stress as compared to the single mutant, and in addition, mutants are slower swimmers, have increased hydrogen peroxide-induced reactive oxygen species (ROS), and reduced mitochondrial mass accompanied by reduced superoxide anion oxidation (PubMed:20578245). Double knockout with chch-3 RNAi results in reduced or no brood, poor growth and withered gonads (PubMed:21248201).
messages: Expressed in embryos.
messages: Expressed in the gonads and muscle cells.
messages: Mitochondrion inner membrane
messages: Sustains mitochondrial morphology probably through maintaining cristae morphology (PubMed:20578245, PubMed:21248201). May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).

6239:CELE F26B1.3
gene id: 6239:CELE_F26B1.3
uniprot id: P91276
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the importin alpha family.
messages: Cytoplasm
messages: Embryonic lethality associated with a terminal aneuploid phenotype: embryos display severe defects in nuclear envelope formation, accumulating nucleoporins and lamin in the cytoplasm (PubMed:12221121). Worms lacking both akir-1 and ima-2 show reduced gonad size and aberrant diakinesis oocyte formation; defects are caused by impaired meiotic recombination (PubMed:30563860).
messages: Expressed weakly in early larvae, levels of expression increase in larval stage 4 and adult stages when germ cells are continually proliferating.
messages: Forms a complex with an importin beta subunit (PubMed:11311162). Interacts with akir-1 (PubMed:30563860).
messages: Germline tissues (PubMed:11311162, PubMed:12221121). Expressed exclusively in germ line cells from the early embryonic through adult stages (PubMed:12221121).
messages: Nuclear transport receptor that mediates nuclear import of proteins, and which is involved in sister chromatid cohesion (PubMed:11311162, PubMed:12221121, PubMed:30563860). Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signals (NLS) motif (By similarity). Promotes docking of import substrates to the nuclear envelope (By similarity). Together with akir-1 adapter, required for the import and load of cohesin complex proteins in meiotic nuclei (PubMed:30563860).
messages: Nucleus
messages: Nucleus envelope

6239:CELE T26C11.5
gene id: 6239:CELE_T26C11.5
uniprot id: Q22810
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE Y19D10A.4
gene id: 6239:CELE_Y19D10A.4
uniprot id: A0A0M7RFG7
uniprot id: G5EDZ6
names: Subcellular Location Annotation
messages: Membrane

6239:CELE T21E3.1
gene id: 6239:CELE_T21E3.1
uniprot id: O01767
names: Caution
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein-tyrosine phosphatase family.
messages: Expressed in developing oocytes (at protein level).
messages: Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition (PubMed:19879842, PubMed:19879147). Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization (PubMed:19879147). Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I (PubMed:19879842). Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization (PubMed:19879147).
messages: Part of a complex, consisting of pseudophosphatases egg-3, egg-4, egg-5 and kinase mbk-2; this complex is required for the oocyte-to-zygote transition (PubMed:19879842). Interacts (via tyrosine-protein phosphatase domain) with kinase mbk-2 (via 'Tyr-619' and 'Tyr-621'); mbk-2 tyrosine phosphorylation enhances the interaction (PubMed:19879842). The interaction inhibits mbk-2 kinase activity and is required for mbk-2 oocyte cortex localization (PubMed:19879842, PubMed:19879147). Interacts with egg-3 (PubMed:19879147).
messages: Severe reduction in the number of hatched larvae (PubMed:19879147). Simultaneous RNAi-mediated knockdown of egg-5 results in no viable progeny and causes endomitosis in the uterus, generation of polyspermic embryos and defects in meiosis completion, polar body formation and eggshell chitin layer formation (PubMed:19879147). In addition, posterior formation of F-actin cap at the cortex oocyte and its polarized dispersal after fertilization are impaired (PubMed:19879147). Prevents mbk-2 localization to the unfertilized oocyte cortex without affecting egg-3 cortical localization (PubMed:19879842, PubMed:19879147). Prevents mbk-2, egg-3 and chs-1 re-localization to cytoplasmic foci at meiosis anaphase I (PubMed:19879147). Simultaneous RNAi-mediated knockdown of egg-5 and mel-26 causes premature phosphorylation of mei-1, a mbk-1 substrate, during oocyte maturation (PubMed:19879842).
messages: The active site Cys-600 is replaced by a Asp residue suggesting that egg-4 may lack catalytic activity. Despite the lack of catalytic activity, egg-4 may retain the capacity to bind to phosphorylated substrates. Does not dephosphorylate mbk-2 (PubMed:19879842).
messages: cell cortex

6239:CELE F58A6.8
gene id: 6239:CELE_F58A6.8
uniprot id: P53017
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C18B12.2
gene id: 6239:CELE_C18B12.2
uniprot id: G5EBF7
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F45C12.15
gene id: 6239:CELE_F45C12.15
uniprot id: O16749
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE K08F4.8
gene id: 6239:CELE_K08F4.8
uniprot id: P53020
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE C17D12.2
gene id: 6239:CELE_C17D12.2
uniprot id: A0A0K3AWH2
uniprot id: G5EE68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

6239:CELE F53F4.9
gene id: 6239:CELE_F53F4.9
uniprot id: K8F7R4
uniprot id: Q20721
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE E04F6.13
gene id: 6239:CELE_E04F6.13
uniprot id: Q95QP0
names: Similarity
messages: Belongs to the nematode receptor-like protein srd family.

6239:CELE H12I13.4
gene id: 6239:CELE_H12I13.4
uniprot id: Q9N5M6
names: Developmental Stage
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cytoplasm
messages: Expressed specifically in the germline (at protein level).
messages: Expression increases in abundance during postembryonic development and peaks during the fourth larval stage.
messages: Fbf-1 and fbf-2 are >90% identical on both nucleotide and protein sequence level. Experimental approaches often do not distinguish between the two genes, which are collectively referred to as fbf and are considered to be functionally redundant.
messages: Interacts (via C-terminus) with gld-3 isoform A in an RNA-independent manner.
messages: Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline (PubMed:9393998). May also play a role in the hermaphrodite germline proliferation and oogenesis (PubMed:9393998, PubMed:15454534). Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch (PubMed:9393998, PubMed:15454534). Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b (PubMed:9393998, PubMed:15454534). In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone (PubMed:21455289). By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone (PubMed:16319922). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes (PubMed:22820175).

6239:CELE Y42A5A.5
gene id: 6239:CELE_Y42A5A.5
uniprot id: Q7YWR3
names: Similarity
messages: Belongs to the complex I LYR family.

6239:CELE F57B9.3
gene id: 6239:CELE_F57B9.3
uniprot id: Q20935
names: Similarity
messages: Belongs to the DEAD box helicase family.

6239:CELE D2096.3
gene id: 6239:CELE_D2096.3
uniprot id: Q19004
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6239:CELE T07C4.1
gene id: 6239:CELE_T07C4.1
uniprot id: G5EDZ2
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: 56 percent of embryos fail to hatch and are arrested at various stages between the bean stage and the four-fold stage (PubMed:20148972). 30 percent of L1 larvae fail to reach adulthood (PubMed:20148972). Embryos from the bean stage through to hatching have abnormally enlarged gut granules which fail to acidify (PubMed:20148972). Their size and number decreases at the L1 larval stage (PubMed:20148972). Normal gut granules in L2 larvae and adults (PubMed:20148972). Lysosomes in intestinal cells are mislocalized. 7 percent of embryos lack attachment of the anterior pharynx to the buccal cavity (PubMed:20148972). Exposure to hypertonic conditions reduces the number of vacuoles in mutant larvae (PubMed:20148972). Resistance to 5-fluorouracil (5-FU)-mediated toxicity (PubMed:19645718, PubMed:24262006).
messages: Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis (PubMed:19645718). May also form UMP from uracil (PubMed:19645718). Regulates the size of gut granules during embryonic development (PubMed:20148972). Involved in resistance to DNA damaging agents including UV-C and X-ray radiation (PubMed:24262006).
messages: Cytoplasm
messages: Expressed in intestine and in neurons near the nerve ring and rectum.
messages: Expression starts at the early embryonic pretzel-stage in the intestine and in a few cells in the head and the tail, and continues throughout larval stages and adulthood.
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

6239:CELE C25E10.7
gene id: 6239:CELE_C25E10.7
uniprot id: Q18156
names: Subcellular Location Annotation
messages: Secreted

6239:CELE F15B9.2
gene id: 6239:CELE_F15B9.2
uniprot id: Q19477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
messages: Secreted

6239:CELE T10B9.8
gene id: 6239:CELE_T10B9.8
uniprot id: Q27520
names: Function
names: Similarity
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

6239:CELE C06G8.4
gene id: 6239:CELE_C06G8.4
uniprot id: Q17760
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein srd family.
messages: Membrane

6239:CELE Y76B12C.7
gene id: 6239:CELE_Y76B12C.7
uniprot id: Q9N4C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF1 family.
messages: CPSF is a heterotetramer composed of four distinct subunits 160 (cpsf-1), 100 (cpsf-2), 70 (cpsf-3), and 30 kDa (cpsf-4).
messages: CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).
messages: Nucleus

6239:CELE H42K12.1
gene id: 6239:CELE_H42K12.1
uniprot id: Q9Y1J3
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
messages: Cytoplasm
messages: Expressed in late stage embryos and throughout life. At L1, expressed in neurons, intestinal cells and hypodermal cells. In adults, expressed in the somatic gonad.
messages: Interacts directly with sgk-1, akt-1 and akt-2.
messages: Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage (PubMed:10364160, PubMed:21980302). Phosphorylates and activates sgk-1, akt-1 and akt-2 (PubMed:15068796).
messages: The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.

6239:CELE Y52E8A.4
gene id: 6239:CELE_Y52E8A.4
uniprot id: A0A0K3AR66
uniprot id: A0A0K3AUS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

6239:CELE Y67D8C.10
gene id: 6239:CELE_Y67D8C.10
uniprot id: B7CED8
uniprot id: Q95XP5
uniprot id: Q95XP6
uniprot id: U4PMD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6239:CELE C53B4.3
gene id: 6239:CELE_C53B4.3
uniprot id: Q18797
names: Subcellular Location Annotation
messages: Membrane

6239:CELE F41D9.5
gene id: 6239:CELE_F41D9.5
uniprot id: Q94225
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Possible sulfate transporter.

6239:CELE F19B6.1
gene id: 6239:CELE_F19B6.1
uniprot id: Q9U3I7
names: Similarity
messages: Belongs to the uridine kinase family.

6239:CELE C18E3.8
gene id: 6239:CELE_C18E3.8
uniprot id: O02100
names: Developmental Stage
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the peptidase A22A family.
messages: Down-regulated by spr-1, spr-3, spr-4 and spr-5.
messages: Endoplasmic reticulum membrane
messages: Expressed both maternally and zygotically. Predominantly expressed in the adult. Weakly expressed in the embryo, L2 and L3 stages, and almost absent in L1 stage larvae.
messages: Golgi apparatus membrane
messages: Homodimer. Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable).
messages: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function.
messages: The PAL motif is required for normal active site conformation.
messages: Weakly expressed.

6239:CELE D2085.4
gene id: 6239:CELE_D2085.4
uniprot id: O17736
names: Disruption Phenotype
names: Function
names: Subunit
messages: E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos.
messages: Interacts with ify-1 and cyb-1.
messages: RNAi-mediated knockdown causes a reduction in progeny viability. ify-1 and cyb-1 accumulate in the cytoplasm during meiosis II. Also extents the length of meiosis II and causes retention of rec-8, a component of the cohesin complex, at sister chromatid cohesion. Causes a delay in oocyte budding.

6239:CELE C50B6.11
gene id: 6239:CELE_C50B6.11
uniprot id: P91985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6239:CELE ZK430.1
gene id: 6239:CELE_ZK430.1
uniprot id: Q23495
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
messages: nucleolus

6239:CELE F37B4.8
gene id: 6239:CELE_F37B4.8
uniprot id: O45170
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

6239:CELE Y37E11AR.2
gene id: 6239:CELE_Y37E11AR.2
uniprot id: Q965X6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.
messages: Interacts with tir-1.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.

6239:CELE F18C5.8
gene id: 6239:CELE_F18C5.8
uniprot id: Q19552
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F49E11.7
gene id: 6239:CELE_F49E11.7
uniprot id: Q27500
names: Similarity
messages: Belongs to the PPP phosphatase family.

6239:CELE C41C4.2
gene id: 6239:CELE_C41C4.2
uniprot id: Q09273
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sre family.
messages: Cell membrane

6239:CELE E04D5.1
gene id: 6239:CELE_E04D5.1
uniprot id: Q19052
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

6239:CELE R06F6.4
gene id: 6239:CELE_R06F6.4
uniprot id: Q09415
names: Subcellular Location Annotation
messages: Nucleus

6239:CELE T22D1.9
gene id: 6239:CELE_T22D1.9
uniprot id: Q9GZH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

6239:CELE F36H1.10
gene id: 6239:CELE_F36H1.10
uniprot id: D3YT32
uniprot id: Q7YTM7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Constitutively expressed. Not regulated by heme level.
messages: Heme transporter.
messages: Membrane

6239:CELE T03D8.5
gene id: 6239:CELE_T03D8.5
uniprot id: Q9XTY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cell membrane
messages: Expression in ASER neuron begins at an early larval stage and is maintained in the adult.
messages: Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron (PubMed:19523832, PubMed:20837997). May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations (PubMed:19523832).
messages: The extracellular and guanylate cyclase domains are essential for chemosensory responses.
messages: The protein kinase domain is predicted to be catalytically inactive.

6239:CELE F54D5.14
gene id: 6239:CELE_F54D5.14
uniprot id: G5EG17
names: Developmental Stage
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SMC family. SMC6 subfamily.
messages: Chromosome
messages: Core component of the smc-5/smc-6 complex (PubMed:20661436). Involved in DNA double-strand break repair by promoting sister-chromatid homologous recombination during meiosis (PubMed:20661436, PubMed:24939994, PubMed:27010650). Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions (PubMed:24424777). Promotes efficient DNA replication (PubMed:24424777).
messages: Expressed in the germline (at protein level).
messages: Expressed in the primordial germ cells Z2 and Z3 in embryos and in proliferating germ cells in L2/L3 stage larvae (at protein level).
messages: Interacts with smc-5.
messages: Nucleus
messages: Reduced fecundity and transgenerational sterility (PubMed:20661436). Increased germ cell apoptosis and hypersensitivity to ultraviolet and ionizing radiation and hydroxyurea-induced replication stress (PubMed:20661436, PubMed:24424777). Increased rad-51 foci in the mitotic and meiotic germline on autosomes, but not on X chromosomes (PubMed:20661436, PubMed:27010650, PubMed:24424777, PubMed:24939994). Chromosome fragmentation defects and unresolved diakinesis chromosomes in meiotic oocytes (PubMed:20661436, PubMed:27010650). Impaired DNA replication in germ cells (PubMed:24424777). Accumulation of brd-1 on chromosomes in mitotic germ cells (PubMed:24424777). In a him-3 mutant background, increased rad-51 foci and chromosome fragmentation (PubMed:20661436). RNAi-mediated knockdown of syp-2 leads to an increase of chromosome fragmentation (PubMed:20661436). In a him-6 mutant background, leads to synergistic lethality (PubMed:27010650). In a fem-3 or him-8 mutant background, RNAi-mediated knockdown leads to increased fragmentation of autosomes and asynapsed X chromosomes but not of X chromosomes in males (PubMed:24939994).
messages: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc-5, forming a V-shaped heterodimer.

6239:CELE E02C12.5
gene id: 6239:CELE_E02C12.5
uniprot id: P28052
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde-1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways (PubMed:19489741). Involved in behavioral response to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons (PubMed:25303524). Plays a role in the avoidance response to the noxious chemical quinine in ASH sensory neurons (PubMed:14988722).

6239:CELE T08H4.3
gene id: 6239:CELE_T08H4.3
uniprot id: Q22355
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the ETS family.
messages: Expressed in the A-neurons in the male-specific genital sensilla (simple sense organs) known as rays.
messages: Expressed in the embryo in sensory neurons with 6-fold symmetry, probably the inner labial neurons (PubMed:16584723). Expressed between comma and 3-fold stage, diminishing afterwards and absent in larval stages and adults (PubMed:16584723). Expressed in all dopaminergic neurons throughout postembryonic stages (PubMed:19287374). Expressed in a few cells in the pharynx at the 2-fold stage (PubMed:16584723).
messages: Nucleus
messages: RNAi-mediated knockdown abolishes expression of tyrosine monooxygenase cat-2 in neurons in the male-specific genital sensilla (simple sense organs) known as rays.
messages: Transcription factor (PubMed:16584723, PubMed:19287374, PubMed:23788625). Probably binds to DNA sequences containing the consensus motif 5'-CGGA[AT][AG]-3' (PubMed:19287374). Positively modulates expression of dopamine pathway genes, acting as a terminal selector for differentiation of dopaminergic neurons; may act in concert with homeobox proteins ceh-40, ceh-43 and ceh-20 (PubMed:19287374, PubMed:23788625, PubMed:22069471). Required for axon navigation in some interneurons, perhaps acting in the same pathways as basement membrane protein nid-1 and unc-6/netrin (PubMed:16584723). Plays a role in the differentiation of the ventral cord pioneer neuron AVG (PubMed:16584723). Required for morphogenesis of the pharynx (PubMed:16584723).
messages: neuron projection

6239:CELE ZC334.3
gene id: 6239:CELE_ZC334.3
uniprot id: Q9U1P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE T11B7.3
gene id: 6239:CELE_T11B7.3
uniprot id: A5JYR8
uniprot id: A5JYR9
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

6239:CELE Y25C1A.7
gene id: 6239:CELE_Y25C1A.7
uniprot id: H2KY98
uniprot id: Q2Z1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane

6239:CELE R09F10.1
gene id: 6239:CELE_R09F10.1
uniprot id: Q23030
names: Similarity
messages: Belongs to the peptidase C1 family.

6239:CELE Y59A8B.25
gene id: 6239:CELE_Y59A8B.25
uniprot id: Q1RPT8
names: Similarity
messages: Belongs to the SNAP family.

6239:CELE ZK1128.5
gene id: 6239:CELE_ZK1128.5
uniprot id: Q09646
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the SMARCD family.
messages: Broadly expressed in all cell types.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes (Probable). The canonical complex contains a catalytic subunit swsn-4, core subunits swsn-1 and swsn-5, and accessory subunits swsn-3, swsn-6, phf-10, dpff-1, swsn-9 and either ham-3/swsn-2.1 or swsn-2.2 (Probable). May interact with blmp-1 (PubMed:32417234).
messages: First observed after gastrulation and persists into the first larval stages and in the adult.
messages: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Required for the blmp-1-mediated transcriptional activation or repression of several hypodermal genes such as bed-3 (PubMed:32417234). Involved in regulating differentiation, migration and axon pathfinding of specific serotonergic neurons (HSNs) (PubMed:26739451). Probably regulates vulva development through the let-60/Ras pathway (PubMed:26739451). May be involved in regulation of developmental processes in the embryo driven by the Wnt pathway (PubMed:26739451). Involved in gonadogenesis (PubMed:26739451, PubMed:24402584).
messages: Nucleus
messages: RNAi-mediated knockdown at the L1 larval stage reduces brood size (PubMed:26739451). RNAi-mediated knockdown reduces expression of tph-1, which encodes a component of the serotonin synthesis pathway (PubMed:23457234). RNAi-mediated knockdown reduces the level of bed-3 and col-124 mRNAs and increases the level of lin-29 mRNA (PubMed:32417234). Simultaneous knockouts of swsn-2.2 do not survive beyond the L2 larval stage (PubMed:24402584). Simultaneous RNAi-mediated knockdown of swsn-2.2 at the L1 larval stage causes sterility, while at the L3 larval stage, causes embryonic lethality for the progeny (PubMed:26739451). The sterile animals resulting from simultaneous RNAi-mediated knockdown of swsn-2.2 at the L1 larval stage develop smaller germ lines (PubMed:26739451). Simultaneous RNAi-mediated knockdown of swsn-2.2 also results in vulva protrusion and ectopic expression of egl-17 in cells derived from the vulval precursor cells P5.p and P7.p (PubMed:26739451).

6239:CELE Y48G8AR.1
gene id: 6239:CELE_Y48G8AR.1
uniprot id: G5EDF0
uniprot id: W6RT88
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. Grainyhead subfamily.
messages: Expressed in embryos, larvae and adults.
messages: Nucleus
messages: Probable transcription factor that binds a motif with the core sequence 5'-C[ACT][TG]G-3'.
messages: RNAi-mediated knockdown results in defective cuticle development (PubMed:12888489). RNAi-mediated knockdown in L4 stage larvae has no effect, but upon reaching adulthood, over 95% of the embryos produced by these animals arrest and fail to hatch (PubMed:12888489). Development arrests at the three-fold stage, showing abnormal constrictions or puckering in the external cuticle and approximately 8% of embryos exhibit ruptures in their cuticles resulting in the extrusion of cells (PubMed:12888489).

6239:CELE F55F8.5
gene id: 6239:CELE_F55F8.5
uniprot id: P91343
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
messages: nucleolus
messages: nucleoplasm

6239:CELE C56C10.5
gene id: 6239:CELE_C56C10.5
uniprot id: Q18881
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nematode receptor-like protein sra family.
messages: Membrane

6239:CELE F55A11.4
gene id: 6239:CELE_F55A11.4
uniprot id: C8JQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6239:CELE F37B4.2
gene id: 6239:CELE_F37B4.2
uniprot id: O45168
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.

6239:CELE C14B9.8
gene id: 6239:CELE_C14B9.8
uniprot id: P34335
names: Function
names: Similarity
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (By similarity).

6239:CELE C44E4.1
gene id: 6239:CELE_C44E4.1
uniprot id: A0A0S4XR36
uniprot id: O01808
names: Similarity
messages: Belongs to the UBR4 family.

6239:CELE C14C11.3
gene id: 6239:CELE_C14C11.3
uniprot id: G5EFL1
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

6239:CELE C46A5.3
gene id: 6239:CELE_C46A5.3
uniprot id: B2MZB1
uniprot id: P18834
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cuticular collagen family.
messages: Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
messages: Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

6239:CELE Y39A1A.19
gene id: 6239:CELE_Y39A1A.19
uniprot id: G5ECJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

6239:CELE T20B12.1
gene id: 6239:CELE_T20B12.1
uniprot id: P41842
names: Developmental Stage
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the TTC27 family.
messages: Cytoplasm
messages: Developmental protein required for cell fate determination in both the germline and seam cells of the developing epidermis. Specifically, involved in sex determination and may function in parallel or downstream of other sex determination factors, including tra-2 and fem-3, to promote oogenesis in its role in the regulation of the switch from spermatogenesis to oogenesis in the gonads. Also implicated in the mitosis to meiosis switch in distal tip cells.
messages: Expressed in seam cells throughout postembryonic development. Expressed in the developing gonad, distal tip cells and spermatheca from larval stage L3.
messages: Expressed in the spermatheca.
messages: High level of lethality with a significant reduction in seam cell number. RNAi-mediated knockdown results in defects linked to cell fate determination including impaired hypodermal differentiation, fewer seam cells, possibly due to a change in cell fate, a molting defect in 10% of animals and male tail abnormalities, including reduced sensory ray number. The germline exhibits a mog (masculinization of the germline) phenotype with increased sperm numbers and largely absent oocytes in the gonad. Defective mitosis to meiosis switching and general impaired morphology in distal tip cells with abnormal extending processes (cytonemes) that are thicker and extend further into the proximal gonad from early stages of development.

6239:CELE K07F5.2
gene id: 6239:CELE_K07F5.2
uniprot id: P05634
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Around 30 MSP isoforms may exist in C.elegans.
messages: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
messages: Sperm.
messages: cytoskeleton
messages: pseudopodium

6239:CELE ZK643.1
gene id: 6239:CELE_ZK643.1
uniprot id: I2HAB8
uniprot id: I2HAB9
uniprot id: P30647
names: Similarity
messages: Belongs to the arrestin family.

6239:CELE D1044.3
gene id: 6239:CELE_D1044.3
uniprot id: P41951
names: Subcellular Location Annotation
messages: Membrane

6239:CELE C26D10.3
gene id: 6239:CELE_C26D10.3
uniprot id: Q18213
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.

6239:CELE T03E6.3
gene id: 6239:CELE_T03E6.3
uniprot id: Q9XU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F44C4.2
gene id: 6239:CELE_F44C4.2
uniprot id: Q20389
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

6239:CELE F49C12.8
gene id: 6239:CELE_F49C12.8
uniprot id: Q20585
names: Function
names: Similarity
names: Tissue Specificity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S10 family.
messages: Expressed in multiple tissues including the intestine, pharynx and hypodermis.

6239:CELE K01D12.14
gene id: 6239:CELE_K01D12.14
uniprot id: G5EGC7
names: Similarity
messages: Belongs to the FAX family.

6239:CELE Y8A9A.6
gene id: 6239:CELE_Y8A9A.6
uniprot id: Q9TYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

6239:CELE F14F7.2
gene id: 6239:CELE_F14F7.2
uniprot id: O17806
names: Similarity
messages: Belongs to the cytochrome P450 family.

6239:CELE H25P06.1
gene id: 6239:CELE_H25P06.1
uniprot id: Q9XU15
names: Similarity
messages: Belongs to the hexokinase family.

6239:CELE ZK550.6
gene id: 6239:CELE_ZK550.6
uniprot id: O62515
names: Function
names: Similarity
messages: Belongs to the PhyH family.
messages: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.

6239:CELE Y57G11C.13
gene id: 6239:CELE_Y57G11C.13
uniprot id: G5EDC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Lysosome membrane

6239:CELE H28O16.1
gene id: 6239:CELE_H28O16.1
uniprot id: Q9XXK1
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and is required for the assimilation of enterobactin-bound iron from non-pathogenic bacteria. Promotes mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159).
messages: Mitochondrion
messages: Mitochondrion inner membrane
messages: RNAi-mediated knockdown of the protein leads to impaired growth and development. In addition, it impairs the assimilation of enterobactin-bound iron.
messages: Subunit of the F-type ATPase which has 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: The siderophore enterobactin (Ent) produced by enteric bacteria binds Fe(3+) and helps them scavenge iron ions from the environment. Enterobactin produced by non-pathogenic E.coli strains facilitates iron assimilation in C.elegans (PubMed:30146159). Other siderophores, such as ferrichrome and pyoverdine that is produced by pathogenic bacteria, do not facilitate intestinal iron absorption in C.elegans (PubMed:30146159).
messages: Ubiquitous (at protein level).

6239:CELE T10F2.3
gene id: 6239:CELE_T10F2.3
uniprot id: Q09353
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: Nucleus envelope
messages: Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.
messages: RNAi-mediated knockdown causes increased presence of smo-1 conjugates during the first embryonic mitotic division.