61853:KHDC3L
gene id: 61853:KHDC3L
uniprot id: G1QKH1
names: Similarity
messages: Belongs to the KHDC1 family.

61853:GPR157
gene id: 61853:GPR157
uniprot id: G1RDI8
names: Subcellular Location Annotation
messages: Membrane

61853:PAXBP1
gene id: 61853:PAXBP1
uniprot id: G1QUH6
names: Similarity
messages: Belongs to the GCF family.

61853:PCMTD1
gene id: 61853:PCMTD1
uniprot id: G1QIP4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61853:B3GAT2
gene id: 61853:B3GAT2
uniprot id: G1QJQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:ATP6V0A2
gene id: 61853:ATP6V0A2
uniprot id: G1QNC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

61853:ADH1B
gene id: 61853:ADH1B
uniprot id: A0A2I3HZ96
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61853:RPL5
gene id: 61853:RPL5
uniprot id: G1RHR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

61853:TXNRD1
gene id: 61853:TXNRD1
uniprot id: G1R475
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

61853:VDR
gene id: 61853:VDR
uniprot id: G1S8A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

61853:ST8SIA1
gene id: 61853:ST8SIA1
uniprot id: G1QYM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:AP5M1
gene id: 61853:AP5M1
uniprot id: G1RRC4
names: Subcellular Location Annotation
names: Subunit
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

61853:AP3M2
gene id: 61853:AP3M2
uniprot id: G1RQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

61853:SERINC5
gene id: 61853:SERINC5
uniprot id: A0A2I3HZ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

61853:IL36G
gene id: 61853:IL36G
uniprot id: A0A2I3GMW0
uniprot id: G1QN31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61853:NIPAL2
gene id: 61853:NIPAL2
uniprot id: G1QQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61853:DESI1
gene id: 61853:DESI1
uniprot id: G1S096
names: Similarity
messages: Belongs to the DeSI family.

61853:REEP4
gene id: 61853:REEP4
uniprot id: M3ZB55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:CLCN5
gene id: 61853:CLCN5
uniprot id: A0A2I3HN01
uniprot id: G1R9L3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
messages: Cell membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Interacts with NEDD4 and NEDD4L.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:EXOSC5
gene id: 61853:EXOSC5
uniprot id: G1RTP2
names: Subcellular Location Annotation
messages: Cytoplasm

61853:LOC100594235
gene id: 61853:LOC100594235
uniprot id: G1S045
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

61853:SLC11A1
gene id: 61853:SLC11A1
uniprot id: G1RBA4
names: Similarity
messages: Belongs to the NRAMP family.

61853:IGFBP5
gene id: 61853:IGFBP5
uniprot id: G1R6Q6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:CCNA2
gene id: 61853:CCNA2
uniprot id: G1RDS0
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

61853:INMT
gene id: 61853:INMT
uniprot id: G1RYW1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

61853:WFIKKN2
gene id: 61853:WFIKKN2
uniprot id: A0A2I3H3L6
names: Similarity
messages: Belongs to the WFIKKN family.

61853:UNC5CL
gene id: 61853:UNC5CL
uniprot id: G1QYX1
names: Similarity
messages: Belongs to the unc-5 family.

61853:LOC100591180
gene id: 61853:LOC100591180
uniprot id: A0A2I3HFN4
names: Similarity
messages: Belongs to the histone H3 family.

61853:PLCZ1
gene id: 61853:PLCZ1
uniprot id: G1QWP9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

61853:PARL
gene id: 61853:PARL
uniprot id: A0A2I3HNQ7
uniprot id: G1R2D6
names: Subcellular Location Annotation
messages: Membrane

61853:SMCO2
gene id: 61853:SMCO2
uniprot id: G1R0D8
names: Subcellular Location Annotation
messages: Membrane

61853:SLC35F2
gene id: 61853:SLC35F2
uniprot id: G1R6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

61853:LOC100581858
gene id: 61853:LOC100581858
uniprot id: G1S9A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:TCEA1
gene id: 61853:TCEA1
uniprot id: G1QJV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

61853:ABRACL
gene id: 61853:ABRACL
uniprot id: A0A2I3G5U2
names: Similarity
messages: Belongs to the costars family.

61853:MMGT1
gene id: 61853:MMGT1
uniprot id: G1QPD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

61853:LOC100593126
gene id: 61853:LOC100593126
uniprot id: G1S9J2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:TMEM182
gene id: 61853:TMEM182
uniprot id: G1RXC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

61853:LETM2
gene id: 61853:LETM2
uniprot id: A0A2I3HJU9
names: Subcellular Location Annotation
messages: Membrane

61853:LPAR4
gene id: 61853:LPAR4
uniprot id: G1SBK7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:ACR
gene id: 61853:ACR
uniprot id: G1QKK8
names: Function
names: Subunit
messages: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
messages: Heavy chain (catalytic) and a light chain linked by two disulfide bonds. Forms a heterodimer with SERPINA5.

61853:RARB
gene id: 61853:RARB
uniprot id: G1QU20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61853:PDE1A
gene id: 61853:PDE1A
uniprot id: A0A2I3G921
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:POMK
gene id: 61853:POMK
uniprot id: G1RR88
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

61853:MED29
gene id: 61853:MED29
uniprot id: G1RWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

61853:TMEM38B
gene id: 61853:TMEM38B
uniprot id: A0A2I3H147
uniprot id: G1S678
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

61853:RPL17
gene id: 61853:RPL17
uniprot id: A0A2I3GXY8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61853:TDP1
gene id: 61853:TDP1
uniprot id: A0A2I3H8R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

61853:CACFD1
gene id: 61853:CACFD1
uniprot id: G1RS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

61853:CAB39L
gene id: 61853:CAB39L
uniprot id: G1QTT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

61853:DEF8
gene id: 61853:DEF8
uniprot id: A0A2I3G8E8
names: Similarity
messages: Belongs to the DEF8 family.

61853:SI
gene id: 61853:SI
uniprot id: G1QY24
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:IRGM
gene id: 61853:IRGM
uniprot id: C3UZU9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

61853:TMEM183A
gene id: 61853:TMEM183A
uniprot id: G1S907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

61853:LOC100591991
gene id: 61853:LOC100591991
uniprot id: G1RDH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

61853:SOX9
gene id: 61853:SOX9
uniprot id: A0A2I3G6W7
names: Subcellular Location Annotation
messages: Nucleus

61853:PSIP1
gene id: 61853:PSIP1
uniprot id: G1S757
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

61853:ZIC2
gene id: 61853:ZIC2
uniprot id: G1R8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

61853:UCHL1
gene id: 61853:UCHL1
uniprot id: A0A2I3HF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:RPL15
gene id: 61853:RPL15
uniprot id: A0A2I3G2C0
uniprot id: G1QTQ8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61853:VAMP1
gene id: 61853:VAMP1
uniprot id: G1QU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61853:CD55
gene id: 61853:CD55
uniprot id: A0A2I3H2K1
uniprot id: A0A2I3H749
uniprot id: G1QJZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:DGKB
gene id: 61853:DGKB
uniprot id: G1S2U8
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61853:RTF2
gene id: 61853:RTF2
uniprot id: G1R5V8
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

61853:SYNDIG1
gene id: 61853:SYNDIG1
uniprot id: G1S000
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:DDIT4L
gene id: 61853:DDIT4L
uniprot id: G1RTG4
names: Similarity
messages: Belongs to the DDIT4 family.

61853:AK6
gene id: 61853:AK6
uniprot id: A0A2I3HKT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

61853:PKIA
gene id: 61853:PKIA
uniprot id: G1QNA1
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

61853:ITPKB
gene id: 61853:ITPKB
uniprot id: G1RUG9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61853:CD200
gene id: 61853:CD200
uniprot id: A0A2I3FWF0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:ZDHHC6
gene id: 61853:ZDHHC6
uniprot id: G1S129
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:LSM1
gene id: 61853:LSM1
uniprot id: A0A2I3HZW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

61853:TIGD1
gene id: 61853:TIGD1
uniprot id: G1S9M7
names: Subcellular Location Annotation
messages: Nucleus

61853:ALKAL2
gene id: 61853:ALKAL2
uniprot id: A0A2I3GYA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

61853:GCLM
gene id: 61853:GCLM
uniprot id: G1RJ06
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

61853:AKAP12
gene id: 61853:AKAP12
uniprot id: A0A2I3GLF0
uniprot id: G1RZJ5
names: Subcellular Location Annotation
messages: Membrane

61853:FAM114A2
gene id: 61853:FAM114A2
uniprot id: A0A2I3GJY3
names: Similarity
messages: Belongs to the FAM114 family.

61853:LOC100607281
gene id: 61853:LOC100607281
uniprot id: A0A2I3HIR5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

61853:RAN
gene id: 61853:RAN
uniprot id: A0A2I3H4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

61853:LOC100599925
gene id: 61853:LOC100599925
uniprot id: G1SB22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

61853:GCNT4
gene id: 61853:GCNT4
uniprot id: G1S9D8
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61853:UBE2E3
gene id: 61853:UBE2E3
uniprot id: G1R373
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:PPM1G
gene id: 61853:PPM1G
uniprot id: G1QTW4
names: Similarity
messages: Belongs to the PP2C family.

61853:LBR
gene id: 61853:LBR
uniprot id: A0A2I3H2J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

61853:RBP4
gene id: 61853:RBP4
uniprot id: G1RQU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Interacts with TTR.
messages: Retinol-binding protein that mediates retinol transport in blood plasma.
messages: Secreted

61853:LOC100607627
gene id: 61853:LOC100607627
uniprot id: G1S6V7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61853:SEMA3E
gene id: 61853:SEMA3E
uniprot id: G1RXV2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:COQ3
gene id: 61853:COQ3
uniprot id: G1RTK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

61853:AGL
gene id: 61853:AGL
uniprot id: G1RLT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

61853:BMP2
gene id: 61853:BMP2
uniprot id: G1RV31
names: Similarity
messages: Belongs to the TGF-beta family.

61853:IRX2
gene id: 61853:IRX2
uniprot id: G1RK74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

61853:AIDA
gene id: 61853:AIDA
uniprot id: G1RTA2
names: Similarity
messages: Belongs to the AIDA family.

61853:CCN2
gene id: 61853:CCN2
uniprot id: G1RWQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:BPIFC
gene id: 61853:BPIFC
uniprot id: G1QYI0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

61853:LCE2D
gene id: 61853:LCE2D
uniprot id: G1RH93
names: Similarity
messages: Belongs to the LCE family.

61853:PTN
gene id: 61853:PTN
uniprot id: G1RTF8
names: Similarity
messages: Belongs to the pleiotrophin family.

61853:LOC100586304
gene id: 61853:LOC100586304
uniprot id: G1SC39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ODF1
gene id: 61853:ODF1
uniprot id: G1QTW7
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

61853:TGIF1
gene id: 61853:TGIF1
uniprot id: A0A2I3HM26
uniprot id: A0A2I3HPT4
names: Subcellular Location Annotation
messages: Nucleus

61853:GOLT1A
gene id: 61853:GOLT1A
uniprot id: G1RVL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

61853:ARPC5L
gene id: 61853:ARPC5L
uniprot id: G1S679
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

61853:FUT11
gene id: 61853:FUT11
uniprot id: G1S471
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane
messages: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors.

61853:PRKAA1
gene id: 61853:PRKAA1
uniprot id: G1S3D1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

61853:TMOD3
gene id: 61853:TMOD3
uniprot id: G1R3U4
names: Subcellular Location Annotation
messages: cytoskeleton

61853:GALNTL5
gene id: 61853:GALNTL5
uniprot id: G1QXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

61853:OSM
gene id: 61853:OSM
uniprot id: A0A2I3GYK4
uniprot id: G1QTJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

61853:TTR
gene id: 61853:TTR
uniprot id: G1R3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

61853:KCNH1
gene id: 61853:KCNH1
uniprot id: G1QPR1
names: Subcellular Location Annotation
messages: Membrane

61853:FOXN3
gene id: 61853:FOXN3
uniprot id: A0A2I3GYP6
names: Subcellular Location Annotation
messages: Nucleus

61853:ADAM12
gene id: 61853:ADAM12
uniprot id: G1QJE1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:DOK6
gene id: 61853:DOK6
uniprot id: G1RCZ4
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

61853:EEF1A1
gene id: 61853:EEF1A1
uniprot id: A0A2I3HHP9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61853:DTNA
gene id: 61853:DTNA
uniprot id: G1R3A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

61853:NLK
gene id: 61853:NLK
uniprot id: G1QMQ8
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

61853:NEURL2
gene id: 61853:NEURL2
uniprot id: G1R4Z8
names: Subcellular Location Annotation
messages: Cytoplasm

61853:ING4
gene id: 61853:ING4
uniprot id: G1QWX0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61853:RPL36
gene id: 61853:RPL36
uniprot id: G1RTM2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

61853:TDGF1
gene id: 61853:TDGF1
uniprot id: G1R2M8
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:NR0B2
gene id: 61853:NR0B2
uniprot id: G1RDZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

61853:CHD7
gene id: 61853:CHD7
uniprot id: A0A2I3GT41
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

61853:GATB
gene id: 61853:GATB
uniprot id: G1R1L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

61853:LOC100606147
gene id: 61853:LOC100606147
uniprot id: G1RCE7
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:CASR
gene id: 61853:CASR
uniprot id: G1QHE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:SNCA
gene id: 61853:SNCA
uniprot id: G1RW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse
messages: axon

61853:MS4A2
gene id: 61853:MS4A2
uniprot id: A0A2I3HNR3
uniprot id: A0A2I3HX60
names: Similarity
messages: Belongs to the MS4A family.

61853:LECT2
gene id: 61853:LECT2
uniprot id: G1RA57
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

61853:S100A2
gene id: 61853:S100A2
uniprot id: G1RHG7
names: Similarity
messages: Belongs to the S-100 family.

61853:IMPAD1
gene id: 61853:IMPAD1
uniprot id: G1QKW2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61853:DNPEP
gene id: 61853:DNPEP
uniprot id: G1RE20
names: Similarity
names: Subunit
messages: Belongs to the peptidase M18 family.
messages: Tetrahedron-shaped homododecamer built from six homodimers.

61853:PON2
gene id: 61853:PON2
uniprot id: G1S130
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

61853:FAR2
gene id: 61853:FAR2
uniprot id: G1R0S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

61853:AMIGO3
gene id: 61853:AMIGO3
uniprot id: G1SA89
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

61853:DYNC1I1
gene id: 61853:DYNC1I1
uniprot id: G1S1E0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

61853:DNAJA4
gene id: 61853:DNAJA4
uniprot id: G1RAW1
names: Subcellular Location Annotation
messages: Membrane

61853:FANCM
gene id: 61853:FANCM
uniprot id: A0A2I3HXM4
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

61853:SLC39A3
gene id: 61853:SLC39A3
uniprot id: A0A2I3H310
names: Subcellular Location Annotation
messages: Membrane

61853:TMCC3
gene id: 61853:TMCC3
uniprot id: G1R1A6
names: Similarity
messages: Belongs to the TEX28 family.

61853:MCOLN3
gene id: 61853:MCOLN3
uniprot id: A0A2I3GXL0
uniprot id: G1RG44
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61853:SLC10A4
gene id: 61853:SLC10A4
uniprot id: G1S6H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61853:NAA30
gene id: 61853:NAA30
uniprot id: G1RRD1
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

61853:GRID2
gene id: 61853:GRID2
uniprot id: G1RVW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

61853:MS4A4A
gene id: 61853:MS4A4A
uniprot id: A0A2I3HN35
uniprot id: G1RSG5
names: Similarity
messages: Belongs to the MS4A family.

61853:PTAR1
gene id: 61853:PTAR1
uniprot id: A0A2I3H3C2
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

61853:HARBI1
gene id: 61853:HARBI1
uniprot id: G1RUU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

61853:PTK7
gene id: 61853:PTK7
uniprot id: A0A2I3HRK6
names: Subcellular Location Annotation
messages: Membrane

61853:CD5L
gene id: 61853:CD5L
uniprot id: G1RRC5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MRPS10
gene id: 61853:MRPS10
uniprot id: A0A2I3G6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

61853:STATH
gene id: 61853:STATH
uniprot id: A0A2I3GGL2
uniprot id: G1R7Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
messages: Secreted

61853:YPEL5
gene id: 61853:YPEL5
uniprot id: G1RZT5
names: Similarity
messages: Belongs to the yippee family.

61853:HS6ST1
gene id: 61853:HS6ST1
uniprot id: G1S1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

61853:NPC1L1
gene id: 61853:NPC1L1
uniprot id: A0A2I3H0I0
uniprot id: G1QUH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

61853:CCNYL1
gene id: 61853:CCNYL1
uniprot id: G1R667
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

61853:S100B
gene id: 61853:S100B
uniprot id: G1QSV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

61853:ESR2
gene id: 61853:ESR2
uniprot id: A0A2I3H3K6
uniprot id: A0A2I3HIJ7
uniprot id: G1RVD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61853:CPLX2
gene id: 61853:CPLX2
uniprot id: G1QID6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61853:FOXI2
gene id: 61853:FOXI2
uniprot id: G1QIC1
names: Subcellular Location Annotation
messages: Nucleus

61853:CXCL6
gene id: 61853:CXCL6
uniprot id: G1R8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:CHST6
gene id: 61853:CHST6
uniprot id: G1RRF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61853:MYCL
gene id: 61853:MYCL
uniprot id: G1RN33
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

61853:ATP6AP2
gene id: 61853:ATP6AP2
uniprot id: G1QLK9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

61853:MAPKAPK3
gene id: 61853:MAPKAPK3
uniprot id: G1R5T7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:OPN1MW
gene id: 61853:OPN1MW
uniprot id: G1RU23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

61853:CAMP
gene id: 61853:CAMP
uniprot id: G1R3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

61853:LOC100589568
gene id: 61853:LOC100589568
uniprot id: G1S3F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

61853:RFC4
gene id: 61853:RFC4
uniprot id: G1R4J2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

61853:LOC100604647
gene id: 61853:LOC100604647
uniprot id: G1QP52
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:DPYSL3
gene id: 61853:DPYSL3
uniprot id: G1RG10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: growth cone

61853:SEM1
gene id: 61853:SEM1
uniprot id: A0A2I3G278
uniprot id: G1S1L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

61853:BOLA2B
gene id: 61853:BOLA2B
uniprot id: A0A2I3GLW4
names: Similarity
messages: Belongs to the BolA/IbaG family.

61853:MDFI
gene id: 61853:MDFI
uniprot id: A0A2I3H3Z7
uniprot id: G1QYG0
names: Similarity
messages: Belongs to the MDFI family.

61853:PVALB
gene id: 61853:PVALB
uniprot id: G1RX85
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

61853:PIGC
gene id: 61853:PIGC
uniprot id: G1RZ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

61853:SLC25A18
gene id: 61853:SLC25A18
uniprot id: G1R8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:TMEM147
gene id: 61853:TMEM147
uniprot id: G1RKA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:OGG1
gene id: 61853:OGG1
uniprot id: A0A2I3GAC1
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

61853:RRP7A
gene id: 61853:RRP7A
uniprot id: A0A2I3H015
names: Similarity
messages: Belongs to the RRP7 family.

61853:HPS6
gene id: 61853:HPS6
uniprot id: G1SBR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

61853:HINT2
gene id: 61853:HINT2
uniprot id: A0A2I3HTB9
names: Similarity
messages: Belongs to the HINT family.

61853:MAOB
gene id: 61853:MAOB
uniprot id: G1QPV3
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

61853:CHST10
gene id: 61853:CHST10
uniprot id: G1RW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:NAGA
gene id: 61853:NAGA
uniprot id: G1S0X4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

61853:FOXN1
gene id: 61853:FOXN1
uniprot id: G1QPC4
names: Subcellular Location Annotation
messages: Nucleus

61853:GTPBP8
gene id: 61853:GTPBP8
uniprot id: A0A2I3GXL5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

61853:HTR3E
gene id: 61853:HTR3E
uniprot id: A0A2I3HBI9
uniprot id: G1R2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

61853:HTRA1
gene id: 61853:HTRA1
uniprot id: G1S581
names: Similarity
messages: Belongs to the peptidase S1C family.

61853:DDX21
gene id: 61853:DDX21
uniprot id: G1RLM7
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.

61853:WASHC3
gene id: 61853:WASHC3
uniprot id: G1R3G5
names: Similarity
messages: Belongs to the CCDC53 family.

61853:ZIC4
gene id: 61853:ZIC4
uniprot id: G1QPN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

61853:SUSD6
gene id: 61853:SUSD6
uniprot id: G1QLT4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:IL23A
gene id: 61853:IL23A
uniprot id: G1S6V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

61853:YOD1
gene id: 61853:YOD1
uniprot id: G1QJN7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

61853:LOC100586892
gene id: 61853:LOC100586892
uniprot id: G1S1L5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

61853:POMGNT2
gene id: 61853:POMGNT2
uniprot id: G1R1Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:NAB1
gene id: 61853:NAB1
uniprot id: A0A2I3FXT4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

61853:PSMA3
gene id: 61853:PSMA3
uniprot id: G1RRR8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61853:TGFBR2
gene id: 61853:TGFBR2
uniprot id: A0A2I3H3F9
uniprot id: G1QVR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

61853:DKC1
gene id: 61853:DKC1
uniprot id: G1RW04
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

61853:AIMP2
gene id: 61853:AIMP2
uniprot id: A0A2I3H899
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

61853:CYTB
gene id: 61853:CYTB
uniprot id: E5DW44
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

61853:FUCA1
gene id: 61853:FUCA1
uniprot id: G1RBV2
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

61853:PIPOX
gene id: 61853:PIPOX
uniprot id: G1QSK9
names: Similarity
messages: Belongs to the MSOX/MTOX family.

61853:TNFAIP6
gene id: 61853:TNFAIP6
uniprot id: G1RJ80
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:FAM24B
gene id: 61853:FAM24B
uniprot id: A0A2I3HNE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM24 family.
messages: Secreted

61853:LOC100606376
gene id: 61853:LOC100606376
uniprot id: G1QZU8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:LOC105739662
gene id: 61853:LOC105739662
uniprot id: A0A2I3G397
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61853:VANGL1
gene id: 61853:VANGL1
uniprot id: A0A2I3H432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

61853:ATP5PB
gene id: 61853:ATP5PB
uniprot id: G1QV65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

61853:WNK1
gene id: 61853:WNK1
uniprot id: A0A2I3GCL4
uniprot id: A0A2I3HNY6
uniprot id: A0A2I3HU96
uniprot id: G1QPM5
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

61853:PPDPF
gene id: 61853:PPDPF
uniprot id: G1RGC5
names: Similarity
messages: Belongs to the PPDPF family.

61853:MCM10
gene id: 61853:MCM10
uniprot id: G1RNT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

61853:NSG2
gene id: 61853:NSG2
uniprot id: G1QI84
names: Similarity
messages: Belongs to the NSG family.

61853:CLRN3
gene id: 61853:CLRN3
uniprot id: G1QIC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

61853:NXPH2
gene id: 61853:NXPH2
uniprot id: G1RCC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

61853:KCNK2
gene id: 61853:KCNK2
uniprot id: G1RW39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61853:CRAT
gene id: 61853:CRAT
uniprot id: G1S7C3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61853:RBM47
gene id: 61853:RBM47
uniprot id: G1S5P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

61853:CLCN1
gene id: 61853:CLCN1
uniprot id: G1QSM6
names: Subcellular Location Annotation
messages: Membrane

61853:RPIA
gene id: 61853:RPIA
uniprot id: G1QSD6
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

61853:FAM189A1
gene id: 61853:FAM189A1
uniprot id: G1RPE3
names: Similarity
messages: Belongs to the ENTREP family.

61853:ACVR1
gene id: 61853:ACVR1
uniprot id: G1QJA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61853:RPS3A
gene id: 61853:RPS3A
uniprot id: G1R1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

61853:CHAF1B
gene id: 61853:CHAF1B
uniprot id: G1QWT6
names: Subcellular Location Annotation
messages: Nucleus

61853:ZSCAN12
gene id: 61853:ZSCAN12
uniprot id: A0A2I3HKR0
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC15A2
gene id: 61853:SLC15A2
uniprot id: A0A2I3G8C1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

61853:GJD2
gene id: 61853:GJD2
uniprot id: G1RJX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:ALKBH6
gene id: 61853:ALKBH6
uniprot id: G1RLP2
names: Similarity
messages: Belongs to the alkB family.

61853:LOC100605478
gene id: 61853:LOC100605478
uniprot id: A0A2I3H5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:LOC100579320
gene id: 61853:LOC100579320
uniprot id: A0A2I3HUJ6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:SND1
gene id: 61853:SND1
uniprot id: G1RNW5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

61853:PPP1R2
gene id: 61853:PPP1R2
uniprot id: G1RAE4
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

61853:GUCY1A1
gene id: 61853:GUCY1A1
uniprot id: G1R2Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

61853:FMNL3
gene id: 61853:FMNL3
uniprot id: A0A2I3H8A6
uniprot id: G1S809
names: Similarity
messages: Belongs to the formin homology family.

61853:EML5
gene id: 61853:EML5
uniprot id: A0A2I3GLG1
uniprot id: G1S518
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

61853:TNFSF11
gene id: 61853:TNFSF11
uniprot id: A0A2I3FWG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

61853:MC3R
gene id: 61853:MC3R
uniprot id: G1SC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

61853:LYPLAL1
gene id: 61853:LYPLAL1
uniprot id: A0A2I3H8E3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

61853:TSPO
gene id: 61853:TSPO
uniprot id: G1S1Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane
messages: Mitochondrion membrane

61853:ITGA9
gene id: 61853:ITGA9
uniprot id: A0A2I3HRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61853:CCR2
gene id: 61853:CCR2
uniprot id: G1RS01
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:KCNJ13
gene id: 61853:KCNJ13
uniprot id: G1RW76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61853:ETV6
gene id: 61853:ETV6
uniprot id: G1QTB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:TRAM2
gene id: 61853:TRAM2
uniprot id: G1QUA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

61853:SLC1A2
gene id: 61853:SLC1A2
uniprot id: A0A2I3GBH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

61853:LOC100595527
gene id: 61853:LOC100595527
uniprot id: A0A2I3H8U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:BRMS1
gene id: 61853:BRMS1
uniprot id: G1R2G4
names: Subcellular Location Annotation
messages: Nucleus

61853:LAMA4
gene id: 61853:LAMA4
uniprot id: G1RRG8
names: Caution
names: Function
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:EBF4
gene id: 61853:EBF4
uniprot id: G1RD02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61853:SMIM7
gene id: 61853:SMIM7
uniprot id: A0A2I3H1M6
names: Similarity
messages: Belongs to the SMIM7 family.

61853:EIF2B1
gene id: 61853:EIF2B1
uniprot id: A0A2I3HZ59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

61853:UTS2
gene id: 61853:UTS2
uniprot id: G1RBW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

61853:BORA
gene id: 61853:BORA
uniprot id: A0A2I3HK76
uniprot id: G1S1R4
names: Similarity
messages: Belongs to the BORA family.

61853:KARS1
gene id: 61853:KARS1
uniprot id: A0A2I3GJB4
uniprot id: G1RRL2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61853:ACO1
gene id: 61853:ACO1
uniprot id: G1QTE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
messages: cytosol

61853:GATA3
gene id: 61853:GATA3
uniprot id: G1RMR6
names: Subcellular Location Annotation
messages: Nucleus

61853:CCDC103
gene id: 61853:CCDC103
uniprot id: G1QZC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

61853:CTTNBP2
gene id: 61853:CTTNBP2
uniprot id: G1RM35
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CTTN/cortactin SH3 domain. Interacts with STRN, STRN4/zinedin and MOB4/phocein; this interaction may regulate dendritic spine distribution of STRN and STRN4 in hippocampal neurons. Activation of glutamate receptors weakens the interaction with STRN and STRN4.
messages: Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
messages: cell cortex
messages: dendritic spine

61853:MAFB
gene id: 61853:MAFB
uniprot id: G1R3T7
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

61853:LTB
gene id: 61853:LTB
uniprot id: A0A0U5CJC9
uniprot id: G1R2L2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61853:CRYBB3
gene id: 61853:CRYBB3
uniprot id: G1R847
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

61853:CRP
gene id: 61853:CRP
uniprot id: G1RS43
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:LOC100603596
gene id: 61853:LOC100603596
uniprot id: G1SCB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ZNF287
gene id: 61853:ZNF287
uniprot id: A0A2I3GRJ7
names: Subcellular Location Annotation
messages: Nucleus

61853:S100A7
gene id: 61853:S100A7
uniprot id: G1RHF4
names: Similarity
messages: Belongs to the S-100 family.

61853:ARPC1A
gene id: 61853:ARPC1A
uniprot id: G1RJF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

61853:CA11
gene id: 61853:CA11
uniprot id: G1QX88
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

61853:DSEL
gene id: 61853:DSEL
uniprot id: G1SA09
names: Similarity
messages: Belongs to the dermatan-sulfate isomerase family.

61853:EGFLAM
gene id: 61853:EGFLAM
uniprot id: A0A2I3GPH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PGM3
gene id: 61853:PGM3
uniprot id: A0A2I3GLF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

61853:NIF3L1
gene id: 61853:NIF3L1
uniprot id: G1R5I3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

61853:EXOSC8
gene id: 61853:EXOSC8
uniprot id: G1QMJ8
names: Subcellular Location Annotation
messages: Cytoplasm

61853:ANAPC4
gene id: 61853:ANAPC4
uniprot id: G1S4N5
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

61853:INSL6
gene id: 61853:INSL6
uniprot id: G1RCJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: May have a role in sperm development and fertilization.
messages: Secreted

61853:SLC13A1
gene id: 61853:SLC13A1
uniprot id: G1RN91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61853:TRMT13
gene id: 61853:TRMT13
uniprot id: A0A2I3HEU0
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

61853:WDR35
gene id: 61853:WDR35
uniprot id: G1QP20
uniprot id: M3ZB26
names: Function
names: Subcellular Location Annotation
messages: As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.
messages: centrosome
messages: cilium basal body

61853:ESRRG
gene id: 61853:ESRRG
uniprot id: A0A2I3HQE9
uniprot id: G1RVM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61853:TOMM7
gene id: 61853:TOMM7
uniprot id: A0A2I3HZT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

61853:CCNJL
gene id: 61853:CCNJL
uniprot id: A0A2I3HMK6
names: Similarity
messages: Belongs to the cyclin family.

61853:TOM1L1
gene id: 61853:TOM1L1
uniprot id: G1R947
names: Similarity
messages: Belongs to the TOM1 family.

61853:METTL6
gene id: 61853:METTL6
uniprot id: A0A2I3G9M1
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.

61853:KCNC2
gene id: 61853:KCNC2
uniprot id: A0A2I3HKC4
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100586622
gene id: 61853:LOC100586622
uniprot id: G1RWZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61853:TGFB2
gene id: 61853:TGFB2
uniprot id: A0A2I3GW08
uniprot id: G1RVC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

61853:DXO
gene id: 61853:DXO
uniprot id: G1R3V9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Binds 2 magnesium ions.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

61853:LOC100586929
gene id: 61853:LOC100586929
uniprot id: G1QTU3
names: Similarity
messages: Belongs to the SPAN-X family.

61853:DNAJA2
gene id: 61853:DNAJA2
uniprot id: G1S0P3
names: Subcellular Location Annotation
messages: Membrane

61853:NPC2
gene id: 61853:NPC2
uniprot id: A0A2I3HN70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

61853:MON2
gene id: 61853:MON2
uniprot id: A0A2I3GEP6
uniprot id: A0A2I3GH18
uniprot id: A0A2I3GNT3
names: Similarity
messages: Belongs to the MON2 family.

61853:LOC100604848
gene id: 61853:LOC100604848
uniprot id: G1S9K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:TBCA
gene id: 61853:TBCA
uniprot id: A0A2I3GWX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

61853:SLC12A6
gene id: 61853:SLC12A6
uniprot id: A0A2I3FY94
uniprot id: A0A2I3GV01
uniprot id: A0A2I3HZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61853:WNT6
gene id: 61853:WNT6
uniprot id: G1RCK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:AWAT2
gene id: 61853:AWAT2
uniprot id: G1QIW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

61853:SLC9B1
gene id: 61853:SLC9B1
uniprot id: M3ZB54
names: Subcellular Location Annotation
messages: Membrane

61853:LAMTOR3
gene id: 61853:LAMTOR3
uniprot id: G1RTM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

61853:TPD52
gene id: 61853:TPD52
uniprot id: A0A2I3GQN3
uniprot id: A0A2I3H321
uniprot id: A0A2I3HEE0
uniprot id: G1QPH6
names: Similarity
messages: Belongs to the TPD52 family.

61853:PIAS2
gene id: 61853:PIAS2
uniprot id: A0A2I3GI93
uniprot id: G1RKU4
names: Similarity
messages: Belongs to the PIAS family.

61853:DMGDH
gene id: 61853:DMGDH
uniprot id: G1RQP4
names: Similarity
messages: Belongs to the GcvT family.

61853:ZSCAN16
gene id: 61853:ZSCAN16
uniprot id: G1QWT8
names: Subcellular Location Annotation
messages: Nucleus

61853:GPR152
gene id: 61853:GPR152
uniprot id: G1SB83
names: Subcellular Location Annotation
messages: Cell membrane

61853:C1QBP
gene id: 61853:C1QBP
uniprot id: A0A2I3HP96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAM33 family.
messages: Cell membrane

61853:FGF16
gene id: 61853:FGF16
uniprot id: G1QK87
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:SCN3B
gene id: 61853:SCN3B
uniprot id: A0A2I3H6W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

61853:CSTA
gene id: 61853:CSTA
uniprot id: G1QHF2
names: Similarity
messages: Belongs to the cystatin family.

61853:PACC1
gene id: 61853:PACC1
uniprot id: G1QRD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

61853:UBE2L6
gene id: 61853:UBE2L6
uniprot id: A0A2I3GB03
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:ZIC1
gene id: 61853:ZIC1
uniprot id: A0A2I3HPN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

61853:MCHR1
gene id: 61853:MCHR1
uniprot id: G1RZH5
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

61853:CASP9
gene id: 61853:CASP9
uniprot id: A0A2I3GAX9
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:CYSLTR1
gene id: 61853:CYSLTR1
uniprot id: G1QNF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:AP1B1
gene id: 61853:AP1B1
uniprot id: G1QRQ0
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61853:ARL5A
gene id: 61853:ARL5A
uniprot id: G1RK72
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61853:DDX59
gene id: 61853:DDX59
uniprot id: G1S8W5
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX59 subfamily.

61853:ZSCAN10
gene id: 61853:ZSCAN10
uniprot id: G1REM6
names: Subcellular Location Annotation
messages: Nucleus

61853:ACTN3
gene id: 61853:ACTN3
uniprot id: G1R2R8
names: Similarity
messages: Belongs to the alpha-actinin family.

61853:SCTR
gene id: 61853:SCTR
uniprot id: G1RH59
names: Subcellular Location Annotation
messages: Membrane

61853:IL1RAPL2
gene id: 61853:IL1RAPL2
uniprot id: G1RTG0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61853:PIP4P2
gene id: 61853:PIP4P2
uniprot id: G1QPQ0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

61853:SYF2
gene id: 61853:SYF2
uniprot id: A0A2I3HZ55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

61853:CNTNAP4
gene id: 61853:CNTNAP4
uniprot id: G1RRS8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:DNAJC16
gene id: 61853:DNAJC16
uniprot id: G1R7U4
uniprot id: M3ZB76
names: Subcellular Location Annotation
messages: Membrane

61853:DUSP3
gene id: 61853:DUSP3
uniprot id: G1R137
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61853:GRAMD1C
gene id: 61853:GRAMD1C
uniprot id: G1QXN3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:PHYHIPL
gene id: 61853:PHYHIPL
uniprot id: G1RNU6
names: Similarity
messages: Belongs to the PHYHIP family.

61853:CCL22
gene id: 61853:CCL22
uniprot id: A0A2I3H9H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61853:SLC45A1
gene id: 61853:SLC45A1
uniprot id: G1RC02
names: Subcellular Location Annotation
messages: Membrane

61853:OLFM4
gene id: 61853:OLFM4
uniprot id: G1S108
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:C2H16orf87
gene id: 61853:C2H16orf87
uniprot id: G1S0H9
names: Similarity
messages: Belongs to the UPF0547 family.

61853:EXOSC7
gene id: 61853:EXOSC7
uniprot id: G1R280
names: Subcellular Location Annotation
messages: Cytoplasm

61853:YIF1B
gene id: 61853:YIF1B
uniprot id: A0A2I3HXL8
uniprot id: G1S4V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

61853:UPK1B
gene id: 61853:UPK1B
uniprot id: G1QY17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).
messages: Membrane

61853:TMEM43
gene id: 61853:TMEM43
uniprot id: G1QYM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

61853:PLA2G4A
gene id: 61853:PLA2G4A
uniprot id: G1S8S8
names: Domain
messages: The N-terminal C2 domain associates with lipid membranes upon calcium binding.

61853:APOC3
gene id: 61853:APOC3
uniprot id: G1R6X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

61853:PDE1B
gene id: 61853:PDE1B
uniprot id: A0A2I3GV81
uniprot id: G1S7A7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:POLL
gene id: 61853:POLL
uniprot id: G1RXX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

61853:USP16
gene id: 61853:USP16
uniprot id: G1QSD9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

61853:METTL3
gene id: 61853:METTL3
uniprot id: G1RWX6
names: Similarity
messages: Belongs to the MT-A70-like family.

61853:ANKRD13A
gene id: 61853:ANKRD13A
uniprot id: G1QQB4
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

61853:LOC100594283
gene id: 61853:LOC100594283
uniprot id: A0A2I3GMF3
names: Similarity
messages: Belongs to the calcitonin family.

61853:CRB1
gene id: 61853:CRB1
uniprot id: A0A2I3GQB3
uniprot id: G1S8V2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TAT
gene id: 61853:TAT
uniprot id: G1R1D7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

61853:NFU1
gene id: 61853:NFU1
uniprot id: G1RGG8
names: Similarity
messages: Belongs to the NifU family.

61853:IRF2
gene id: 61853:IRF2
uniprot id: G1RJ05
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:HSD17B2
gene id: 61853:HSD17B2
uniprot id: G1RIG2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:IZUMO4
gene id: 61853:IZUMO4
uniprot id: A0A2I3GKS1
uniprot id: G1QNE0
names: Similarity
messages: Belongs to the Izumo family.

61853:CA1
gene id: 61853:CA1
uniprot id: G1QRE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

61853:UPK1A
gene id: 61853:UPK1A
uniprot id: G1RKG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:NOL11
gene id: 61853:NOL11
uniprot id: G1QLL5
names: Subcellular Location Annotation
messages: nucleolus

61853:LOC100600963
gene id: 61853:LOC100600963
uniprot id: G1SC61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:NUDT18
gene id: 61853:NUDT18
uniprot id: A0A2I3HER2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

61853:PTPRG
gene id: 61853:PTPRG
uniprot id: A0A2I3H9Q3
uniprot id: G1RLQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

61853:HYAL1
gene id: 61853:HYAL1
uniprot id: G1R5P3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

61853:BMP4
gene id: 61853:BMP4
uniprot id: G1RQ54
names: Similarity
messages: Belongs to the TGF-beta family.

61853:CHST2
gene id: 61853:CHST2
uniprot id: G1QYK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61853:STXBP3
gene id: 61853:STXBP3
uniprot id: G1QN24
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61853:CALB1
gene id: 61853:CALB1
uniprot id: G1QPC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

61853:MX1
gene id: 61853:MX1
uniprot id: G1RBH6
uniprot id: K4JR57
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

61853:CTNNB1
gene id: 61853:CTNNB1
uniprot id: A0A2I3HZB4
uniprot id: G1R1B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: adherens junction

61853:ROMO1
gene id: 61853:ROMO1
uniprot id: G1RHA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

61853:TYROBP
gene id: 61853:TYROBP
uniprot id: G1RLK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TYROBP family.
messages: Cell membrane
messages: Membrane

61853:RETREG1
gene id: 61853:RETREG1
uniprot id: A0A2I3H7X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

61853:CCT3
gene id: 61853:CCT3
uniprot id: G1RPV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

61853:CSN2
gene id: 61853:CSN2
uniprot id: G1R7Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-casein family.
messages: Important role in determination of the surface properties of the casein micelles.
messages: Secreted

61853:GHITM
gene id: 61853:GHITM
uniprot id: A0A2I3G315
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

61853:EPN1
gene id: 61853:EPN1
uniprot id: G1RI64
names: Similarity
messages: Belongs to the epsin family.

61853:PLBD1
gene id: 61853:PLBD1
uniprot id: G1QUM3
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

61853:SPR
gene id: 61853:SPR
uniprot id: A0A2I3GCA6
names: Similarity
messages: Belongs to the sepiapterin reductase family.

61853:TINAGL1
gene id: 61853:TINAGL1
uniprot id: G1QN12
names: Similarity
messages: Belongs to the peptidase C1 family.

61853:MTCH1
gene id: 61853:MTCH1
uniprot id: G1RJP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:TRPM7
gene id: 61853:TRPM7
uniprot id: G1R398
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
messages: Membrane

61853:ZDHHC15
gene id: 61853:ZDHHC15
uniprot id: A0A2I3G564
uniprot id: G1QK60
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:LOC100584971
gene id: 61853:LOC100584971
uniprot id: G1S982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:AKAP4
gene id: 61853:AKAP4
uniprot id: G1R9M2
names: Similarity
messages: Belongs to the AKAP110 family.

61853:SRD5A1
gene id: 61853:SRD5A1
uniprot id: G1RKY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

61853:LOC100581434
gene id: 61853:LOC100581434
uniprot id: A0A2I3HL22
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:GTPBP10
gene id: 61853:GTPBP10
uniprot id: G1RYU0
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

61853:GABRA2
gene id: 61853:GABRA2
uniprot id: G1S691
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

61853:H1-1
gene id: 61853:H1-1
uniprot id: G1S9Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61853:RNF20
gene id: 61853:RNF20
uniprot id: G1S5M8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

61853:NLN
gene id: 61853:NLN
uniprot id: A0A2I3HC35
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

61853:UBE2B
gene id: 61853:UBE2B
uniprot id: G1R9J2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:TM6SF2
gene id: 61853:TM6SF2
uniprot id: G1R2Z2
names: Subcellular Location Annotation
messages: Membrane

61853:LHPP
gene id: 61853:LHPP
uniprot id: G1QI70
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

61853:PPP2R2C
gene id: 61853:PPP2R2C
uniprot id: G1RM57
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

61853:GINS4
gene id: 61853:GINS4
uniprot id: G1RPX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

61853:KCNQ5
gene id: 61853:KCNQ5
uniprot id: A0A2I3HKC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:AMPD1
gene id: 61853:AMPD1
uniprot id: A0A2I3GH93
uniprot id: G1QY15
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61853:CAMK1G
gene id: 61853:CAMK1G
uniprot id: G1QM17
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:MGMT
gene id: 61853:MGMT
uniprot id: G1QLG0
names: Function
names: Similarity
messages: Belongs to the MGMT family.
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

61853:PDS5A
gene id: 61853:PDS5A
uniprot id: G1S5L8
names: Similarity
messages: Belongs to the PDS5 family.

61853:CAVIN4
gene id: 61853:CAVIN4
uniprot id: A0A2I3HSE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

61853:ATP6V1G3
gene id: 61853:ATP6V1G3
uniprot id: G1S8V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61853:SFPQ
gene id: 61853:SFPQ
uniprot id: A0A2I3GVW0
names: Subcellular Location Annotation
messages: Nucleus speckle

61853:SCN7A
gene id: 61853:SCN7A
uniprot id: G1QTL3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

61853:RIPK2
gene id: 61853:RIPK2
uniprot id: G1QN93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

61853:MRPL15
gene id: 61853:MRPL15
uniprot id: A0A2I3G0R3
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

61853:SDHD
gene id: 61853:SDHD
uniprot id: A0A2I3H5U8
uniprot id: A0A2I3H863
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

61853:RASSF5
gene id: 61853:RASSF5
uniprot id: G1QIK8
names: Subcellular Location Annotation
messages: cytoskeleton

61853:SSR1
gene id: 61853:SSR1
uniprot id: G1RLH8
uniprot id: M3ZAD8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

61853:STK32C
gene id: 61853:STK32C
uniprot id: G1QMP0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:LOC100603673
gene id: 61853:LOC100603673
uniprot id: G1S7S0
names: Similarity
messages: Belongs to the intermediate filament family.

61853:RPS29
gene id: 61853:RPS29
uniprot id: A0A2I3G8X8
uniprot id: G1RMQ5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

61853:SH3BGRL2
gene id: 61853:SH3BGRL2
uniprot id: A0A2I3HKF9
names: Similarity
messages: Belongs to the SH3BGR family.

61853:PER2
gene id: 61853:PER2
uniprot id: G1RKG3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:LOC100593830
gene id: 61853:LOC100593830
uniprot id: G1RRH1
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61853:SLC10A7
gene id: 61853:SLC10A7
uniprot id: A0A2I3GG96
uniprot id: A0A2I3GHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Cell membrane
messages: Does not show transport activity towards bile acids or steroid sulfates.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

61853:BCLAF3
gene id: 61853:BCLAF3
uniprot id: A0A2I3GLJ6
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

61853:ND4
gene id: 61853:ND4
uniprot id: E7EAD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61853:ZDHHC7
gene id: 61853:ZDHHC7
uniprot id: G1RKQ5
uniprot id: M3Z9X7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:SLC25A13
gene id: 61853:SLC25A13
uniprot id: G1S1K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

61853:ANO4
gene id: 61853:ANO4
uniprot id: A0A2I3G9L5
uniprot id: A0A2I3H7Y8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:CORIN
gene id: 61853:CORIN
uniprot id: A0A2I3GRQ5
uniprot id: G1S6D4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100602585
gene id: 61853:LOC100602585
uniprot id: G1R850
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

61853:ASB7
gene id: 61853:ASB7
uniprot id: G1QJX0
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:QPCT
gene id: 61853:QPCT
uniprot id: G1S2M5
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

61853:RGN
gene id: 61853:RGN
uniprot id: G1QRR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

61853:LOC100591198
gene id: 61853:LOC100591198
uniprot id: M3Z937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

61853:CSN3
gene id: 61853:CSN3
uniprot id: G1R800
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

61853:MRPS30
gene id: 61853:MRPS30
uniprot id: A0A2I3GMS3
names: Subcellular Location Annotation
messages: Mitochondrion

61853:TRMT2B
gene id: 61853:TRMT2B
uniprot id: G1R7H6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:DDX1
gene id: 61853:DDX1
uniprot id: A0A2I3HKV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX1 subfamily.
messages: Cytoplasmic granule

61853:VIL1
gene id: 61853:VIL1
uniprot id: G1RBF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

61853:ADSS1
gene id: 61853:ADSS1
uniprot id: G1S2R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

61853:IL1RL2
gene id: 61853:IL1RL2
uniprot id: A0A2I3G6G7
uniprot id: G1RX28
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61853:DEFB124
gene id: 61853:DEFB124
uniprot id: G1REK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:PPP3R1
gene id: 61853:PPP3R1
uniprot id: G1RG24
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

61853:LOC100581890
gene id: 61853:LOC100581890
uniprot id: G1S3W7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:ABCG4
gene id: 61853:ABCG4
uniprot id: G1R740
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61853:DCP1B
gene id: 61853:DCP1B
uniprot id: G1QQS6
names: Similarity
messages: Belongs to the DCP1 family.

61853:FAM174A
gene id: 61853:FAM174A
uniprot id: A0A2I3GFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

61853:AMHR2
gene id: 61853:AMHR2
uniprot id: A0A2I3HSE3
uniprot id: G1S7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane
messages: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

61853:PNRC1
gene id: 61853:PNRC1
uniprot id: G1RRK5
names: Subcellular Location Annotation
messages: Nucleus

61853:MAGOH
gene id: 61853:MAGOH
uniprot id: A0A2I3G4C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

61853:DAG1
gene id: 61853:DAG1
uniprot id: G1R572
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

61853:RRP15
gene id: 61853:RRP15
uniprot id: A0A2I3GEH8
names: Similarity
messages: Belongs to the RRP15 family.

61853:OAZ2
gene id: 61853:OAZ2
uniprot id: A0A2I3G823
names: Similarity
messages: Belongs to the ODC antizyme family.

61853:PIM2
gene id: 61853:PIM2
uniprot id: G1R8Y1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

61853:TRIM71
gene id: 61853:TRIM71
uniprot id: G1QWN9
names: Similarity
messages: Belongs to the TRIM/RBCC family.

61853:RPS8
gene id: 61853:RPS8
uniprot id: G1RVA5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

61853:GRIK2
gene id: 61853:GRIK2
uniprot id: A0A2I3GH36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

61853:LOC100601784
gene id: 61853:LOC100601784
uniprot id: G1S990
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100601581
gene id: 61853:LOC100601581
uniprot id: A0A2I3FXW2
uniprot id: G1RVF6
names: Similarity
messages: Belongs to the Luc7 family.

61853:LOC100597206
gene id: 61853:LOC100597206
uniprot id: G1R7V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

61853:BMP8B
gene id: 61853:BMP8B
uniprot id: G1RN07
names: Similarity
messages: Belongs to the TGF-beta family.

61853:SLC7A13
gene id: 61853:SLC7A13
uniprot id: A0A2I3HJ49
uniprot id: G1QLF7
names: Subcellular Location Annotation
messages: Membrane

61853:ZRANB1
gene id: 61853:ZRANB1
uniprot id: G1QIF2
names: Similarity
messages: Belongs to the peptidase C64 family.

61853:KRT85
gene id: 61853:KRT85
uniprot id: A0A2I3GSY4
uniprot id: G1S7R8
names: Similarity
messages: Belongs to the intermediate filament family.

61853:TATDN1
gene id: 61853:TATDN1
uniprot id: G1R0A8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

61853:KIF14
gene id: 61853:KIF14
uniprot id: G1S8W4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:KITLG
gene id: 61853:KITLG
uniprot id: G1R0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

61853:C18H16orf91
gene id: 61853:C18H16orf91
uniprot id: A0A2I3G2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCSMST1 family.
messages: Membrane

61853:TMEM11
gene id: 61853:TMEM11
uniprot id: G1QGQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

61853:ELOVL3
gene id: 61853:ELOVL3
uniprot id: G1RYE8
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61853:CAT
gene id: 61853:CAT
uniprot id: G1S8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

61853:NDUFA11
gene id: 61853:NDUFA11
uniprot id: A0A2I3HHP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:DUPD1
gene id: 61853:DUPD1
uniprot id: G1S4L5
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61853:SMG8
gene id: 61853:SMG8
uniprot id: G1RB31
names: Function
names: Similarity
messages: Belongs to the SMG8 family.
messages: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

61853:ST6GALNAC5
gene id: 61853:ST6GALNAC5
uniprot id: G1RES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:TMOD2
gene id: 61853:TMOD2
uniprot id: G1R3T0
names: Subcellular Location Annotation
messages: cytoskeleton

61853:IL5
gene id: 61853:IL5
uniprot id: G1RQD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-5 family.
messages: Homodimer; disulfide-linked.
messages: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
messages: Secreted

61853:TSR2
gene id: 61853:TSR2
uniprot id: A0A2I3GBF4
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

61853:C1QA
gene id: 61853:C1QA
uniprot id: G1RA64
names: Function
messages: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

61853:TXLNG
gene id: 61853:TXLNG
uniprot id: G1REH4
names: Similarity
messages: Belongs to the taxilin family.

61853:CCBE1
gene id: 61853:CCBE1
uniprot id: G1RAP7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:FOLH1B
gene id: 61853:FOLH1B
uniprot id: A0A2I3GIK2
uniprot id: A0A2I3HYJ9
uniprot id: G1S1J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

61853:GDF6
gene id: 61853:GDF6
uniprot id: G1QTN7
names: Similarity
messages: Belongs to the TGF-beta family.

61853:KIFBP
gene id: 61853:KIFBP
uniprot id: G1RLH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

61853:ADGRG5
gene id: 61853:ADGRG5
uniprot id: G1QS61
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100607640
gene id: 61853:LOC100607640
uniprot id: G1RHT3
names: Similarity
messages: Belongs to the GAGE family.

61853:SEC11C
gene id: 61853:SEC11C
uniprot id: A0A2I3H7P2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:LOC100586327
gene id: 61853:LOC100586327
uniprot id: A0A2I3FPQ7
uniprot id: A0A2I3HAX4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

61853:TSHZ3
gene id: 61853:TSHZ3
uniprot id: G1R7S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

61853:GLRA2
gene id: 61853:GLRA2
uniprot id: A0A2I3GR43
uniprot id: G1RDL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

61853:C14H2orf49
gene id: 61853:C14H2orf49
uniprot id: A0A2I3GXX3
uniprot id: A0A2I3HNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

61853:NAGK
gene id: 61853:NAGK
uniprot id: A0A2I3HVP4
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

61853:SOD1
gene id: 61853:SOD1
uniprot id: G1QTN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

61853:B3GALT2
gene id: 61853:B3GALT2
uniprot id: A0A2I3HLP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:LYPD6
gene id: 61853:LYPD6
uniprot id: G1RBL6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:LOC100583044
gene id: 61853:LOC100583044
uniprot id: G1SAM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:PHOX2B
gene id: 61853:PHOX2B
uniprot id: A0A2I3GB05
names: Subcellular Location Annotation
messages: Nucleus

61853:IL22
gene id: 61853:IL22
uniprot id: G1QTK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Secreted

61853:MLEC
gene id: 61853:MLEC
uniprot id: A0A2I3GH34
uniprot id: A0A2I3HCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:SNX8
gene id: 61853:SNX8
uniprot id: G1RBE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

61853:ZC3H12B
gene id: 61853:ZC3H12B
uniprot id: G1QHR7
names: Similarity
messages: Belongs to the ZC3H12 family.

61853:FGF10
gene id: 61853:FGF10
uniprot id: A0A2I3GCN2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:OC90
gene id: 61853:OC90
uniprot id: G1R175
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61853:APOM
gene id: 61853:APOM
uniprot id: G1R2U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

61853:CIAO2B
gene id: 61853:CIAO2B
uniprot id: G1QVS8
names: Similarity
messages: Belongs to the MIP18 family.

61853:DTNB
gene id: 61853:DTNB
uniprot id: G1QL27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

61853:CRKL
gene id: 61853:CRKL
uniprot id: G1QGU0
names: Similarity
messages: Belongs to the CRK family.

61853:IPO9
gene id: 61853:IPO9
uniprot id: G1S8Y1
names: Subcellular Location Annotation
messages: Cytoplasm

61853:KIF9
gene id: 61853:KIF9
uniprot id: A0A2I3HBM7
uniprot id: G1R385
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:CANX
gene id: 61853:CANX
uniprot id: G1QM21
names: Similarity
messages: Belongs to the calreticulin family.

61853:HOXA6
gene id: 61853:HOXA6
uniprot id: G1RY96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61853:DDX31
gene id: 61853:DDX31
uniprot id: G1RR00
names: Similarity
messages: Belongs to the DEAD box helicase family.

61853:XKR9
gene id: 61853:XKR9
uniprot id: G1RKW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61853:RSL24D1
gene id: 61853:RSL24D1
uniprot id: G1R489
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61853:COPS2
gene id: 61853:COPS2
uniprot id: G1R2N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

61853:C7
gene id: 61853:C7
uniprot id: G1S3G7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:PMM1
gene id: 61853:PMM1
uniprot id: A0A2I3H620
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

61853:ASF1A
gene id: 61853:ASF1A
uniprot id: G1RT18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

61853:CNKSR3
gene id: 61853:CNKSR3
uniprot id: A0A2I3FZ66
names: Similarity
messages: Belongs to the CNKSR family.

61853:NIBAN1
gene id: 61853:NIBAN1
uniprot id: G1S8R2
names: Similarity
messages: Belongs to the Niban family.

61853:RAB3C
gene id: 61853:RAB3C
uniprot id: M3ZBG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

61853:RPS12
gene id: 61853:RPS12
uniprot id: G1RWY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

61853:SNRPA1
gene id: 61853:SNRPA1
uniprot id: G1QI33
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

61853:MAPK10
gene id: 61853:MAPK10
uniprot id: G1RDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

61853:AQP1
gene id: 61853:AQP1
uniprot id: A0A2I3I014
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Membrane

61853:SLC2A8
gene id: 61853:SLC2A8
uniprot id: G1S6M4
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61853:EYA4
gene id: 61853:EYA4
uniprot id: A0A2I3H3V5
uniprot id: A0A2I3HF74
uniprot id: G1RX34
uniprot id: G1RX37
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

61853:PRAMEF8
gene id: 61853:PRAMEF8
uniprot id: G1RFK9
names: Similarity
messages: Belongs to the PRAME family.

61853:ARSK
gene id: 61853:ARSK
uniprot id: G1RV90
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61853:GLYATL2
gene id: 61853:GLYATL2
uniprot id: A0A2I3GHL9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61853:BRPF1
gene id: 61853:BRPF1
uniprot id: G1QVN6
names: Subcellular Location Annotation
messages: Nucleus

61853:CDH18
gene id: 61853:CDH18
uniprot id: G1RMU3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:CD4
gene id: 61853:CD4
uniprot id: G1QXL1
names: Subcellular Location Annotation
messages: Cell membrane

61853:KIZ
gene id: 61853:KIZ
uniprot id: A0A2I3HIR1
uniprot id: G1RG02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

61853:AFF4
gene id: 61853:AFF4
uniprot id: G1RQY5
names: Similarity
messages: Belongs to the AF4 family.

61853:PLA2G12A
gene id: 61853:PLA2G12A
uniprot id: A0A2I3HQZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

61853:USP48
gene id: 61853:USP48
uniprot id: A0A2I3HM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Nucleus

61853:PINLYP
gene id: 61853:PINLYP
uniprot id: G1QLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

61853:GALNT11
gene id: 61853:GALNT11
uniprot id: G1QXD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:CRYBG1
gene id: 61853:CRYBG1
uniprot id: G1RSC9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61853:LOC100582085
gene id: 61853:LOC100582085
uniprot id: G1S367
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61853:RAB18
gene id: 61853:RAB18
uniprot id: A0A2I3HCV8
uniprot id: G1S529
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

61853:PSMB1
gene id: 61853:PSMB1
uniprot id: A0A2I3GQJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:SERPIND1
gene id: 61853:SERPIND1
uniprot id: G1QH37
names: Similarity
messages: Belongs to the serpin family.

61853:LOC100590351
gene id: 61853:LOC100590351
uniprot id: G1SCC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:FGFR1OP2
gene id: 61853:FGFR1OP2
uniprot id: A0A2I3FZT3
uniprot id: G1R028
names: Similarity
messages: Belongs to the SIKE family.

61853:ZNF446
gene id: 61853:ZNF446
uniprot id: G1RK17
names: Subcellular Location Annotation
messages: Nucleus

61853:CD68
gene id: 61853:CD68
uniprot id: G1RES7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

61853:DPRX
gene id: 61853:DPRX
uniprot id: G1R2R6
names: Subcellular Location Annotation
messages: Nucleus

61853:CLRN1
gene id: 61853:CLRN1
uniprot id: A0A2I3H394
uniprot id: A0A2I3HQG5
uniprot id: G1QSZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

61853:YWHAB
gene id: 61853:YWHAB
uniprot id: G1R4G7
names: Similarity
messages: Belongs to the 14-3-3 family.

61853:FGF19
gene id: 61853:FGF19
uniprot id: G1RHK0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:ACAD11
gene id: 61853:ACAD11
uniprot id: G1QSQ8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61853:MMP13
gene id: 61853:MMP13
uniprot id: G1R6E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

61853:RTRAF
gene id: 61853:RTRAF
uniprot id: G1RPC2
names: Similarity
messages: Belongs to the RTRAF family.

61853:RRH
gene id: 61853:RRH
uniprot id: G1S3L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:TMEM225
gene id: 61853:TMEM225
uniprot id: G1R773
names: Subcellular Location Annotation
messages: Membrane

61853:ITGA6
gene id: 61853:ITGA6
uniprot id: G1R0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61853:NSMCE2
gene id: 61853:NSMCE2
uniprot id: G1R0K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

61853:AQP9
gene id: 61853:AQP9
uniprot id: G1RKK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61853:TNFSF15
gene id: 61853:TNFSF15
uniprot id: G1S4L9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61853:EIF2AK3
gene id: 61853:EIF2AK3
uniprot id: G1QS89
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61853:HBEGF
gene id: 61853:HBEGF
uniprot id: G1RDD1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CSTF3
gene id: 61853:CSTF3
uniprot id: A0A2I3GDW6
names: Subcellular Location Annotation
messages: Nucleus

61853:CRABP2
gene id: 61853:CRABP2
uniprot id: G1RQE4
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:IAPP
gene id: 61853:IAPP
uniprot id: G1QXX0
names: Function
names: Similarity
messages: Belongs to the calcitonin family.
messages: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

61853:ACYP1
gene id: 61853:ACYP1
uniprot id: A0A2I3HT97
names: Similarity
messages: Belongs to the acylphosphatase family.

61853:WNT11
gene id: 61853:WNT11
uniprot id: G1S4M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:CPLANE2
gene id: 61853:CPLANE2
uniprot id: G1R8H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

61853:MAOA
gene id: 61853:MAOA
uniprot id: A0A2I3HIJ8
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

61853:WNT8A
gene id: 61853:WNT8A
uniprot id: A0A2I3GZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:TMTC3
gene id: 61853:TMTC3
uniprot id: G1R0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

61853:C3H6orf58
gene id: 61853:C3H6orf58
uniprot id: G1RVE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

61853:TIRAP
gene id: 61853:TIRAP
uniprot id: A0A2I3HKD7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer.
messages: Membrane

61853:NDUFA10
gene id: 61853:NDUFA10
uniprot id: A0A2I3HF56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

61853:YAE1
gene id: 61853:YAE1
uniprot id: A0A2I3FPV6
uniprot id: A0A2I3GTD8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:CCDC39
gene id: 61853:CCDC39
uniprot id: G1R1U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

61853:NOG
gene id: 61853:NOG
uniprot id: A0A2I3HGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

61853:ATP1A1
gene id: 61853:ATP1A1
uniprot id: A0A2I3GH95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

61853:NUP58
gene id: 61853:NUP58
uniprot id: A0A2I3GIX1
names: Subcellular Location Annotation
messages: nuclear pore complex

61853:FAM13C
gene id: 61853:FAM13C
uniprot id: A0A2I3FYC9
uniprot id: A0A2I3GPG7
names: Similarity
messages: Belongs to the FAM13 family.

61853:LOC100591753
gene id: 61853:LOC100591753
uniprot id: A0A2I3GWD9
names: Subcellular Location Annotation
messages: Nucleus

61853:GK5
gene id: 61853:GK5
uniprot id: G1QXP4
names: Similarity
messages: Belongs to the FGGY kinase family.

61853:TPT1
gene id: 61853:TPT1
uniprot id: A0A2I3G3E2
names: Similarity
messages: Belongs to the TCTP family.

61853:NPHS2
gene id: 61853:NPHS2
uniprot id: A0A2I3FW22
uniprot id: G1S0Q6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

61853:SNRPD3
gene id: 61853:SNRPD3
uniprot id: A0A2I3HLA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

61853:USP1
gene id: 61853:USP1
uniprot id: G1RY27
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61853:UBE2S
gene id: 61853:UBE2S
uniprot id: G1RHT8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:MUSTN1
gene id: 61853:MUSTN1
uniprot id: A0A2I3H301
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

61853:FAM122C
gene id: 61853:FAM122C
uniprot id: A0A2I3HWT6
uniprot id: G1QNL6
names: Similarity
messages: Belongs to the FAM122 family.

61853:ADAM17
gene id: 61853:ADAM17
uniprot id: G1RT07
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:IL36RN
gene id: 61853:IL36RN
uniprot id: G1QN77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61853:VGLL2
gene id: 61853:VGLL2
uniprot id: A0A2I3H6S2
uniprot id: G1RS91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: Nucleus

61853:HSPB2
gene id: 61853:HSPB2
uniprot id: G1R6R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

61853:LOC100586435
gene id: 61853:LOC100586435
uniprot id: M3ZA25
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

61853:PDX1
gene id: 61853:PDX1
uniprot id: G1QHP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61853:CRABP1
gene id: 61853:CRABP1
uniprot id: G1RB18
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

61853:LOC100580921
gene id: 61853:LOC100580921
uniprot id: G1RZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

61853:MGAT5
gene id: 61853:MGAT5
uniprot id: G1RAF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

61853:BARHL1
gene id: 61853:BARHL1
uniprot id: G1RQV8
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC35E4
gene id: 61853:SLC35E4
uniprot id: G1QV24
names: Subcellular Location Annotation
messages: Membrane

61853:NTMT1
gene id: 61853:NTMT1
uniprot id: A0A2I3GVK4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

61853:ADK
gene id: 61853:ADK
uniprot id: A0A2I3G6Z2
uniprot id: A0A2I3GJH7
uniprot id: A0A2I3GKL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

61853:PPP4R3B
gene id: 61853:PPP4R3B
uniprot id: A0A2I3GK52
uniprot id: A0A2I3H7Q6
names: Similarity
messages: Belongs to the SMEK family.

61853:ISCA2
gene id: 61853:ISCA2
uniprot id: G1S2J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

61853:VEZT
gene id: 61853:VEZT
uniprot id: A0A2I3G3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

61853:TGFA
gene id: 61853:TGFA
uniprot id: G1RGR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:RAMP3
gene id: 61853:RAMP3
uniprot id: G1QVT5
names: Similarity
messages: Belongs to the RAMP family.

61853:LOC100604314
gene id: 61853:LOC100604314
uniprot id: G1QPA8
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:LOC100591599
gene id: 61853:LOC100591599
uniprot id: G1RKB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61853:EAF2
gene id: 61853:EAF2
uniprot id: A0A2I3H636
uniprot id: G1QH83
names: Similarity
messages: Belongs to the EAF family.

61853:RPS6KB1
gene id: 61853:RPS6KB1
uniprot id: A0A2I3HB45
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61853:MARK2
gene id: 61853:MARK2
uniprot id: A0A2I3GR28
uniprot id: A0A2I3GR80
uniprot id: A0A2I3GZV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

61853:GPM6A
gene id: 61853:GPM6A
uniprot id: A0A2I3G7P4
uniprot id: A0A2I3H4I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

61853:RFX3
gene id: 61853:RFX3
uniprot id: G1RC04
names: Subcellular Location Annotation
messages: Nucleus

61853:SGCD
gene id: 61853:SGCD
uniprot id: A0A2I3G2J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

61853:CAMLG
gene id: 61853:CAMLG
uniprot id: G1R9Q3
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

61853:CPLX4
gene id: 61853:CPLX4
uniprot id: G1RAE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61853:GABRA5
gene id: 61853:GABRA5
uniprot id: A0A2I3GX20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:IDH2
gene id: 61853:IDH2
uniprot id: G1RMM2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

61853:LOC100581935
gene id: 61853:LOC100581935
uniprot id: A0A2I3GL97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

61853:CCDC167
gene id: 61853:CCDC167
uniprot id: G1RKC2
names: Subcellular Location Annotation
messages: Membrane

61853:FAM135B
gene id: 61853:FAM135B
uniprot id: G1RIW3
names: Similarity
messages: Belongs to the FAM135 family.

61853:BACE1
gene id: 61853:BACE1
uniprot id: A0A2I3HBH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: trans-Golgi network

61853:SYT1
gene id: 61853:SYT1
uniprot id: G1QYR5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

61853:PPM1K
gene id: 61853:PPM1K
uniprot id: A0A2I3G1K6
names: Similarity
messages: Belongs to the PP2C family.

61853:CCN6
gene id: 61853:CCN6
uniprot id: A0A2I3GDJ0
uniprot id: G1RR76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:MYSM1
gene id: 61853:MYSM1
uniprot id: A0A2I3G9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

61853:WNT2
gene id: 61853:WNT2
uniprot id: Q07DX7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).
messages: Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
messages: Secreted
messages: extracellular matrix

61853:STAG1
gene id: 61853:STAG1
uniprot id: G1QVG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

61853:FEN1
gene id: 61853:FEN1
uniprot id: G1QS65
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300.
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.
messages: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
messages: Mitochondrion
messages: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

61853:LOC100593588
gene id: 61853:LOC100593588
uniprot id: G1S7R3
names: Similarity
messages: Belongs to the intermediate filament family.

61853:UCP2
gene id: 61853:UCP2
uniprot id: G1S5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:CEBPE
gene id: 61853:CEBPE
uniprot id: G1RY61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

61853:CSTF2
gene id: 61853:CSTF2
uniprot id: A0A2I3GPP0
uniprot id: A0A2I3HDC7
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100579700
gene id: 61853:LOC100579700
uniprot id: A0A0M6L0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

61853:LOC100594276
gene id: 61853:LOC100594276
uniprot id: A0A2I3H5M9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:TCP11L2
gene id: 61853:TCP11L2
uniprot id: G1R4H6
names: Similarity
messages: Belongs to the TCP11 family.

61853:SCRN1
gene id: 61853:SCRN1
uniprot id: A0A2I3FVY6
uniprot id: A0A2I3HPZ9
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

61853:LOC100598737
gene id: 61853:LOC100598737
uniprot id: A0A2I3GAU9
uniprot id: G1QNP6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

61853:BCL2A1
gene id: 61853:BCL2A1
uniprot id: A0A2I3GQS0
names: Similarity
messages: Belongs to the Bcl-2 family.

61853:CAPN6
gene id: 61853:CAPN6
uniprot id: G1RWN6
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:ZNF706
gene id: 61853:ZNF706
uniprot id: G1QSM9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:NAA10
gene id: 61853:NAA10
uniprot id: A0A2I3HJQ8
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

61853:LOC100601437
gene id: 61853:LOC100601437
uniprot id: G1RRD4
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:ARFGEF2
gene id: 61853:ARFGEF2
uniprot id: G1R5J0
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

61853:PHACTR3
gene id: 61853:PHACTR3
uniprot id: A0A2I3HNX2
uniprot id: G1REP8
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

61853:C20H2orf76
gene id: 61853:C20H2orf76
uniprot id: A0A2I3FT36
names: Similarity
messages: Belongs to the UPF0538 family.

61853:LOC101176156
gene id: 61853:LOC101176156
uniprot id: A0A2I3GJR7
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61853:OAF
gene id: 61853:OAF
uniprot id: G1R753
names: Similarity
messages: Belongs to the OAF family.

61853:UGCG
gene id: 61853:UGCG
uniprot id: G1S365
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

61853:PITX3
gene id: 61853:PITX3
uniprot id: G1RYF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

61853:AASDHPPT
gene id: 61853:AASDHPPT
uniprot id: G1R6H1
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

61853:PBX2
gene id: 61853:PBX2
uniprot id: G1R4E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

61853:GRIN2A
gene id: 61853:GRIN2A
uniprot id: A0A2I3HEG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61853:CPO
gene id: 61853:CPO
uniprot id: G1R656
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:BET1
gene id: 61853:BET1
uniprot id: A0A2I3HWQ0
names: Subcellular Location Annotation
messages: Membrane

61853:SLX1A
gene id: 61853:SLX1A
uniprot id: G1QJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
messages: Forms a heterodimer with SLX4.
messages: Nucleus

61853:GASK1A
gene id: 61853:GASK1A
uniprot id: G1R1Q5
names: Similarity
messages: Belongs to the GASK family.

61853:KRT6C
gene id: 61853:KRT6C
uniprot id: A0A2I3H0V3
names: Similarity
messages: Belongs to the intermediate filament family.

61853:MATN3
gene id: 61853:MATN3
uniprot id: A0A2I3GRE6
uniprot id: G1QP89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:DEFB128
gene id: 61853:DEFB128
uniprot id: G1REH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:FGF9
gene id: 61853:FGF9
uniprot id: G1RSA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

61853:TUBB2A
gene id: 61853:TUBB2A
uniprot id: A0A2I3GDI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61853:MAP3K7
gene id: 61853:MAP3K7
uniprot id: A0A2I3GLG2
uniprot id: G1RSQ0
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm

61853:AMOT
gene id: 61853:AMOT
uniprot id: G1RX10
names: Similarity
messages: Belongs to the angiomotin family.

61853:CDK6
gene id: 61853:CDK6
uniprot id: G1RZD7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:SCGB1A1
gene id: 61853:SCGB1A1
uniprot id: G1QTG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secretoglobin family.
messages: Secreted

61853:ESRP2
gene id: 61853:ESRP2
uniprot id: A0A2I3GPZ6
uniprot id: G1QZ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

61853:KCNJ15
gene id: 61853:KCNJ15
uniprot id: A0A2I3HPN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61853:SKA2
gene id: 61853:SKA2
uniprot id: G1RAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA2 family.
messages: spindle

61853:SOX3
gene id: 61853:SOX3
uniprot id: G1SB06
names: Subcellular Location Annotation
messages: Nucleus

61853:SENP7
gene id: 61853:SENP7
uniprot id: A0A2I3G8E2
uniprot id: A0A2I3GC85
uniprot id: G1QSH2
names: Similarity
messages: Belongs to the peptidase C48 family.

61853:VCAN
gene id: 61853:VCAN
uniprot id: A0A2I3G769
uniprot id: A0A2I3H1D7
uniprot id: G1RSI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:CCNT2
gene id: 61853:CCNT2
uniprot id: A0A2I3GEQ2
uniprot id: G1RAP6
names: Similarity
messages: Belongs to the cyclin family.

61853:CTSH
gene id: 61853:CTSH
uniprot id: G1RBY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61853:MRPS33
gene id: 61853:MRPS33
uniprot id: G1QP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

61853:TMEM167B
gene id: 61853:TMEM167B
uniprot id: G1RRV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:DPAGT1
gene id: 61853:DPAGT1
uniprot id: G1R737
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:NDUFB10
gene id: 61853:NDUFB10
uniprot id: G1RC64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

61853:CDH13
gene id: 61853:CDH13
uniprot id: G1RIQ9
uniprot id: M3ZBN7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

61853:PENK
gene id: 61853:PENK
uniprot id: G1QKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

61853:TMEM18
gene id: 61853:TMEM18
uniprot id: G1RAG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

61853:LOC100605975
gene id: 61853:LOC100605975
uniprot id: A0A2I3I0K6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:TOP1MT
gene id: 61853:TOP1MT
uniprot id: G1QM08
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

61853:CD52
gene id: 61853:CD52
uniprot id: G1RDK8
names: Function
names: Subcellular Location Annotation
messages: May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
messages: Membrane

61853:TDO2
gene id: 61853:TDO2
uniprot id: G1R355
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CPOX
gene id: 61853:CPOX
uniprot id: A0A2I3HPL9
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

61853:B3GALT1
gene id: 61853:B3GALT1
uniprot id: G1SBH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:UBQLN1
gene id: 61853:UBQLN1
uniprot id: A0A2I3G8B3
uniprot id: A0A2I3HMF6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

61853:IL1RN
gene id: 61853:IL1RN
uniprot id: A0A2I3GF91
uniprot id: G1QNA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

61853:PRDM13
gene id: 61853:PRDM13
uniprot id: G1RU74
names: Subcellular Location Annotation
messages: Nucleus

61853:GMFB
gene id: 61853:GMFB
uniprot id: G1RQB8
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

61853:CCDC172
gene id: 61853:CCDC172
uniprot id: G1S2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

61853:RRP1
gene id: 61853:RRP1
uniprot id: A0A2I3G2R0
names: Similarity
messages: Belongs to the RRP1 family.

61853:HAUS1
gene id: 61853:HAUS1
uniprot id: G1RKA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

61853:NELFCD
gene id: 61853:NELFCD
uniprot id: G1REH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NELF-D family.
messages: Nucleus

61853:SLC39A9
gene id: 61853:SLC39A9
uniprot id: A0A2I3HBV4
uniprot id: G1QLP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

61853:ENDOU
gene id: 61853:ENDOU
uniprot id: G1S8B9
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

61853:EMC4
gene id: 61853:EMC4
uniprot id: A0A2I3FZA3
uniprot id: G1RIX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:MTAP
gene id: 61853:MTAP
uniprot id: A0A2I3GRK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

61853:DTD2
gene id: 61853:DTD2
uniprot id: A0A2I3G2X1
names: Similarity
messages: Belongs to the DTD family.

61853:PARN
gene id: 61853:PARN
uniprot id: G1RH04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

61853:PLAC8
gene id: 61853:PLAC8
uniprot id: G1RCN7
names: Similarity
messages: Belongs to the cornifelin family.

61853:RSBN1L
gene id: 61853:RSBN1L
uniprot id: G1REJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

61853:PSMA8
gene id: 61853:PSMA8
uniprot id: G1R452
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61853:AGK
gene id: 61853:AGK
uniprot id: A0A2I3H099
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

61853:CTSL
gene id: 61853:CTSL
uniprot id: G1R047
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61853:TGFBI
gene id: 61853:TGFBI
uniprot id: G1RAG7
names: Subcellular Location Annotation
messages: extracellular matrix

61853:PPP3CA
gene id: 61853:PPP3CA
uniprot id: A0A2I3GKB6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

61853:ATP6V1G2
gene id: 61853:ATP6V1G2
uniprot id: G1R2H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61853:MALSU1
gene id: 61853:MALSU1
uniprot id: A0A2I3GFU4
names: Similarity
messages: Belongs to the Iojap/RsfS family.

61853:POMGNT1
gene id: 61853:POMGNT1
uniprot id: A0A2I3GF52
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

61853:TRPV2
gene id: 61853:TRPV2
uniprot id: G1RXC4
names: Subcellular Location Annotation
messages: Membrane

61853:RAB14
gene id: 61853:RAB14
uniprot id: G1S5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

61853:P2RX6
gene id: 61853:P2RX6
uniprot id: G1R9A7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61853:LIN7A
gene id: 61853:LIN7A
uniprot id: A0A2I3GAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

61853:CDK8
gene id: 61853:CDK8
uniprot id: G1RUX2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:SLC26A4
gene id: 61853:SLC26A4
uniprot id: G1RBK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

61853:BCAP29
gene id: 61853:BCAP29
uniprot id: A0A2I3HR51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

61853:GALR1
gene id: 61853:GALR1
uniprot id: G1RDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:OCLN
gene id: 61853:OCLN
uniprot id: G1QW88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

61853:NEK7
gene id: 61853:NEK7
uniprot id: G1S8V7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:MRGPRX1
gene id: 61853:MRGPRX1
uniprot id: W8W3L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ATP13A5
gene id: 61853:ATP13A5
uniprot id: G1R4Z4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:ADAM10
gene id: 61853:ADAM10
uniprot id: A0A2I3G1N0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: adherens junction

61853:RPRD1B
gene id: 61853:RPRD1B
uniprot id: G1R386
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

61853:UNC119
gene id: 61853:UNC119
uniprot id: G1QPD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDE6D/unc-119 family.
messages: spindle

61853:SMARCD2
gene id: 61853:SMARCD2
uniprot id: G1QVN7
names: Similarity
messages: Belongs to the SMARCD family.

61853:CCKBR
gene id: 61853:CCKBR
uniprot id: A0A2I3GRH3
uniprot id: G1S6H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

61853:SCML4
gene id: 61853:SCML4
uniprot id: G1RSZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

61853:ANAPC16
gene id: 61853:ANAPC16
uniprot id: A0A2I3FYA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

61853:ZEB2
gene id: 61853:ZEB2
uniprot id: A0A2I3GQ48
uniprot id: G1RCR7
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

61853:TPD52L2
gene id: 61853:TPD52L2
uniprot id: A0A2I3GFX9
uniprot id: A0A2I3GST0
uniprot id: A0A2I3GYA3
uniprot id: A0A2I3HBG5
uniprot id: G1RGR3
names: Similarity
messages: Belongs to the TPD52 family.

61853:LOC100591567
gene id: 61853:LOC100591567
uniprot id: G1S986
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:RPL32
gene id: 61853:RPL32
uniprot id: A0A2I3GE63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

61853:CDC14B
gene id: 61853:CDC14B
uniprot id: G1S4K0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

61853:RRAGA
gene id: 61853:RRAGA
uniprot id: G1SBF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

61853:NME3
gene id: 61853:NME3
uniprot id: G1RBT7
names: Similarity
messages: Belongs to the NDK family.

61853:SLC25A33
gene id: 61853:SLC25A33
uniprot id: A0A2I3HIK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:LOC100604810
gene id: 61853:LOC100604810
uniprot id: G1SAC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:DNAJB14
gene id: 61853:DNAJB14
uniprot id: A0A2I3H167
names: Subcellular Location Annotation
messages: Membrane

61853:GDF2
gene id: 61853:GDF2
uniprot id: G1RZS9
names: Similarity
messages: Belongs to the TGF-beta family.

61853:DNASE2
gene id: 61853:DNASE2
uniprot id: A0A2I3GU79
names: Similarity
messages: Belongs to the DNase II family.

61853:CLUL1
gene id: 61853:CLUL1
uniprot id: A0A2I3H872
uniprot id: G1R564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clusterin family.
messages: Secreted

61853:SLC39A10
gene id: 61853:SLC39A10
uniprot id: G1R502
names: Subcellular Location Annotation
messages: Membrane

61853:ATXN1
gene id: 61853:ATXN1
uniprot id: G1QJZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

61853:POLR2D
gene id: 61853:POLR2D
uniprot id: A0A2I3HS63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

61853:NAT10
gene id: 61853:NAT10
uniprot id: G1S8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

61853:TSPAN1
gene id: 61853:TSPAN1
uniprot id: G1S3V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:SLC25A34
gene id: 61853:SLC25A34
uniprot id: G1R7W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:MMUT
gene id: 61853:MMUT
uniprot id: G1QVV1
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

61853:GNAT2
gene id: 61853:GNAT2
uniprot id: G1QRS9
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61853:CD14
gene id: 61853:CD14
uniprot id: G1RDN0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Interacts with LPAR1.
messages: Cell membrane
messages: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
messages: Golgi apparatus
messages: Membrane
messages: Membrane raft
messages: Secreted

61853:MS4A3
gene id: 61853:MS4A3
uniprot id: A0A2I3H913
uniprot id: G1RS24
names: Similarity
messages: Belongs to the MS4A family.

61853:CRISP2
gene id: 61853:CRISP2
uniprot id: G1QVL3
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CER1
gene id: 61853:CER1
uniprot id: A0A2I3HMH1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:LOC100581904
gene id: 61853:LOC100581904
uniprot id: G1RCK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

61853:PIGG
gene id: 61853:PIGG
uniprot id: A0A2I3HGW0
uniprot id: G1QJB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:MRPL18
gene id: 61853:MRPL18
uniprot id: G1RKD7
names: Similarity
messages: Belongs to the universal ribosomal protein uL18 family.

61853:GABRB1
gene id: 61853:GABRB1
uniprot id: G1S6A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:ORC5
gene id: 61853:ORC5
uniprot id: G1RCX8
names: Subcellular Location Annotation
messages: Nucleus

61853:HJV
gene id: 61853:HJV
uniprot id: G1R1I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

61853:GIMAP1
gene id: 61853:GIMAP1
uniprot id: A0A2I3H0S2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61853:VWC2L
gene id: 61853:VWC2L
uniprot id: G1R6G4
names: Subcellular Location Annotation
messages: Synapse

61853:SLC13A4
gene id: 61853:SLC13A4
uniprot id: G1RT98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61853:ITGA2
gene id: 61853:ITGA2
uniprot id: A0A2I3HG50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61853:DCTD
gene id: 61853:DCTD
uniprot id: A0A2I3GDI3
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

61853:CALHM2
gene id: 61853:CALHM2
uniprot id: G1RZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61853:MBTPS1
gene id: 61853:MBTPS1
uniprot id: G1RJD6
names: Similarity
messages: Belongs to the peptidase S8 family.

61853:OS9
gene id: 61853:OS9
uniprot id: A0A2I3GEX9
uniprot id: A0A2I3HFV8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

61853:HOXD8
gene id: 61853:HOXD8
uniprot id: G1R243
names: Subcellular Location Annotation
messages: Nucleus

61853:TP63
gene id: 61853:TP63
uniprot id: A0A2I3GNV1
uniprot id: A0A2I3H7C7
uniprot id: A0A2I3HR34
uniprot id: G1R4S5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
messages: Cytoplasm
messages: Nucleus

61853:LOC100596110
gene id: 61853:LOC100596110
uniprot id: G1R6W7
names: Similarity
messages: Belongs to the NXPE family.

61853:MINPP1
gene id: 61853:MINPP1
uniprot id: A0A2I3G8H7
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

61853:PTH2
gene id: 61853:PTH2
uniprot id: G1QZ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

61853:DMRTA1
gene id: 61853:DMRTA1
uniprot id: A0A2I3HFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61853:ASIC5
gene id: 61853:ASIC5
uniprot id: G1R330
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

61853:CSNK2A1
gene id: 61853:CSNK2A1
uniprot id: G1RE63
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:ITM2C
gene id: 61853:ITM2C
uniprot id: G1RUC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

61853:ST13
gene id: 61853:ST13
uniprot id: G1RZN4
names: Similarity
messages: Belongs to the FAM10 family.

61853:SURF4
gene id: 61853:SURF4
uniprot id: A0A2I3HCI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

61853:LOC100589965
gene id: 61853:LOC100589965
uniprot id: G1RD74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61853:FOXI1
gene id: 61853:FOXI1
uniprot id: G1QZ13
names: Subcellular Location Annotation
messages: Nucleus

61853:MDH1B
gene id: 61853:MDH1B
uniprot id: G1R648
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

61853:SMAD3
gene id: 61853:SMAD3
uniprot id: A0A2I3HD56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

61853:MID1
gene id: 61853:MID1
uniprot id: G1RCH1
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

61853:PLD5
gene id: 61853:PLD5
uniprot id: G1QUP8
names: Similarity
messages: Belongs to the phospholipase D family.

61853:SPRTN
gene id: 61853:SPRTN
uniprot id: G1QNM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

61853:WDR83OS
gene id: 61853:WDR83OS
uniprot id: G1RQA1
names: Similarity
messages: Belongs to the Asterix family.

61853:CBX5
gene id: 61853:CBX5
uniprot id: G1S7F7
names: Subcellular Location Annotation
messages: Nucleus

61853:KCNK6
gene id: 61853:KCNK6
uniprot id: G1S4T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61853:EPHB1
gene id: 61853:EPHB1
uniprot id: G1QUL1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

61853:PPIE
gene id: 61853:PPIE
uniprot id: A0A2I3HCF9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

61853:NDUFC1
gene id: 61853:NDUFC1
uniprot id: A0A2I3GLF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:LOC100602413
gene id: 61853:LOC100602413
uniprot id: G1S9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:COG6
gene id: 61853:COG6
uniprot id: A0A2I3HR50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

61853:MBOAT1
gene id: 61853:MBOAT1
uniprot id: G1QMB0
names: Subcellular Location Annotation
messages: Membrane

61853:NRTN
gene id: 61853:NRTN
uniprot id: G1RTZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

61853:PHGDH
gene id: 61853:PHGDH
uniprot id: A0A2I3FZC7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

61853:PRDX1
gene id: 61853:PRDX1
uniprot id: A0A2I3HTB8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

61853:FLI1
gene id: 61853:FLI1
uniprot id: A0A2I3H1Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:ALG5
gene id: 61853:ALG5
uniprot id: G1QMA9
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

61853:ISCU
gene id: 61853:ISCU
uniprot id: A0A2I3H0V0
uniprot id: G1R501
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

61853:CLCN6
gene id: 61853:CLCN6
uniprot id: G1RF19
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:VWDE
gene id: 61853:VWDE
uniprot id: G1S2I2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PAQR3
gene id: 61853:PAQR3
uniprot id: A0A2I3HL60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61853:TMEM184C
gene id: 61853:TMEM184C
uniprot id: A0A2I3HKG5
names: Subcellular Location Annotation
messages: Membrane

61853:NME9
gene id: 61853:NME9
uniprot id: A0A2I3FR14
names: Similarity
messages: Belongs to the NDK family.

61853:F8
gene id: 61853:F8
uniprot id: G1RWC7
names: Similarity
messages: Belongs to the multicopper oxidase family.

61853:OTP
gene id: 61853:OTP
uniprot id: G1RQD1
names: Subcellular Location Annotation
messages: Nucleus

61853:PPIC
gene id: 61853:PPIC
uniprot id: G1RN31
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61853:NME7
gene id: 61853:NME7
uniprot id: G1RY63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

61853:SPOPL
gene id: 61853:SPOPL
uniprot id: H9HA37
names: Similarity
messages: Belongs to the Tdpoz family.

61853:EXOC8
gene id: 61853:EXOC8
uniprot id: G1SB12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

61853:SDC4
gene id: 61853:SDC4
uniprot id: G1R4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

61853:DUSP5
gene id: 61853:DUSP5
uniprot id: A0A2I3HMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

61853:HSF2
gene id: 61853:HSF2
uniprot id: A0A2I3HL42
uniprot id: G1RTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61853:CAMK4
gene id: 61853:CAMK4
uniprot id: G1RL45
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:PTPRE
gene id: 61853:PTPRE
uniprot id: A0A2I3GK79
uniprot id: G1QL34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.
messages: Cell membrane
messages: Membrane

61853:FOXN4
gene id: 61853:FOXN4
uniprot id: G1QLV9
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC26A5
gene id: 61853:SLC26A5
uniprot id: A0A2I3H010
uniprot id: A0A2I3HUS7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:SLC25A17
gene id: 61853:SLC25A17
uniprot id: A0A2I3HZK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:LOC100588890
gene id: 61853:LOC100588890
uniprot id: G1QRB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61853:PPP2R2B
gene id: 61853:PPP2R2B
uniprot id: A0A2I3G9W4
uniprot id: A0A2I3H1R1
uniprot id: A0A2I3HFK1
uniprot id: A0A2I3HMQ3
uniprot id: A0A2I3HWZ5
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

61853:ACVR1C
gene id: 61853:ACVR1C
uniprot id: A0A2I3H7Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61853:GABRA1
gene id: 61853:GABRA1
uniprot id: G1QX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:C2H16orf58
gene id: 61853:C2H16orf58
uniprot id: G1S338
names: Similarity
messages: Belongs to the RUS1 family.

61853:SLA2
gene id: 61853:SLA2
uniprot id: G1R2L3
names: Subcellular Location Annotation
messages: Cytoplasm

61853:ASB11
gene id: 61853:ASB11
uniprot id: A0A2I3HG12
uniprot id: G1RDS7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:TXNIP
gene id: 61853:TXNIP
uniprot id: G1R1H4
names: Similarity
messages: Belongs to the arrestin family.

61853:ORMDL2
gene id: 61853:ORMDL2
uniprot id: G1S767
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

61853:OSBPL9
gene id: 61853:OSBPL9
uniprot id: A0A2I3GH05
uniprot id: A0A2I3GMC2
uniprot id: A0A2I3I083
uniprot id: G1S285
names: Similarity
messages: Belongs to the OSBP family.

61853:ELAVL4
gene id: 61853:ELAVL4
uniprot id: A0A2I3FZL4
uniprot id: A0A2I3G9F8
uniprot id: A0A2I3GHA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

61853:CCDC43
gene id: 61853:CCDC43
uniprot id: G1QZI1
names: Similarity
messages: Belongs to the CCDC43 family.

61853:GART
gene id: 61853:GART
uniprot id: G1QV60
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

61853:PPAN
gene id: 61853:PPAN
uniprot id: G1RN34
names: Subcellular Location Annotation
messages: nucleolus

61853:ACTG1
gene id: 61853:ACTG1
uniprot id: G1RTV2
names: Similarity
messages: Belongs to the actin family.

61853:MAL
gene id: 61853:MAL
uniprot id: A0A2I3HEI9
names: Subcellular Location Annotation
messages: Membrane

61853:ANAPC15
gene id: 61853:ANAPC15
uniprot id: A0A2I3H8X8
names: Similarity
messages: Belongs to the APC15 family.

61853:MRPS18B
gene id: 61853:MRPS18B
uniprot id: G1QZE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

61853:DYDC2
gene id: 61853:DYDC2
uniprot id: A0A2I3FVZ4
uniprot id: A0A2I3GTH9
names: Similarity
messages: Belongs to the dpy-30 family.

61853:OPN4
gene id: 61853:OPN4
uniprot id: G1QPI6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:LPGAT1
gene id: 61853:LPGAT1
uniprot id: A0A2I3H1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:SLC35F4
gene id: 61853:SLC35F4
uniprot id: G1RRE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

61853:ARMCX1
gene id: 61853:ARMCX1
uniprot id: G1R7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eutherian X-chromosome-specific Armcx family.
messages: Membrane

61853:GJB5
gene id: 61853:GJB5
uniprot id: G1QTF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:SMR3B
gene id: 61853:SMR3B
uniprot id: G1R810
names: Subcellular Location Annotation
messages: Secreted

61853:MS4A15
gene id: 61853:MS4A15
uniprot id: A0A2I3HS48
uniprot id: G1RT48
names: Similarity
messages: Belongs to the MS4A family.

61853:DDA1
gene id: 61853:DDA1
uniprot id: A0A2I3GAU3
names: Similarity
messages: Belongs to the DDA1 family.

61853:RAP1GDS1
gene id: 61853:RAP1GDS1
uniprot id: A0A2I3G3E1
uniprot id: G1RV47
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Mitochondrion
messages: cytosol

61853:VCX3A
gene id: 61853:VCX3A
uniprot id: A0A2I3HCX0
names: Function
names: Similarity
messages: Belongs to the VCX/VCY family.
messages: May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

61853:SLC35D2
gene id: 61853:SLC35D2
uniprot id: G1S4H4
names: Subcellular Location Annotation
messages: Membrane

61853:HS3ST4
gene id: 61853:HS3ST4
uniprot id: A0A2I3H788
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:LOC100601272
gene id: 61853:LOC100601272
uniprot id: A0A2I3GHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histatin/statherin family.
messages: Secreted

61853:MED27
gene id: 61853:MED27
uniprot id: G1RQR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:CD82
gene id: 61853:CD82
uniprot id: A0A2I3G9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:MCL1
gene id: 61853:MCL1
uniprot id: G1RFT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

61853:GRPEL2
gene id: 61853:GRPEL2
uniprot id: A0A2I3GK17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

61853:RPL30
gene id: 61853:RPL30
uniprot id: A0A2I3G660
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

61853:PROK1
gene id: 61853:PROK1
uniprot id: G1QTW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

61853:SMAD9
gene id: 61853:SMAD9
uniprot id: A0A2I3G2P5
uniprot id: G1QM38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

61853:IARS1
gene id: 61853:IARS1
uniprot id: G1S2U5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61853:ERG
gene id: 61853:ERG
uniprot id: A0A2I3G7C8
uniprot id: A0A2I3HJ74
uniprot id: G1QXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:FN3KRP
gene id: 61853:FN3KRP
uniprot id: G1RHW6
names: Similarity
messages: Belongs to the fructosamine kinase family.

61853:NMBR
gene id: 61853:NMBR
uniprot id: G1RYG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:BMPR1A
gene id: 61853:BMPR1A
uniprot id: G1QPZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61853:ADAMDEC1
gene id: 61853:ADAMDEC1
uniprot id: G1S1N5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MTTP
gene id: 61853:MTTP
uniprot id: G1RU25
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100588080
gene id: 61853:LOC100588080
uniprot id: G1QQ94
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61853:FAM32A
gene id: 61853:FAM32A
uniprot id: G1R067
names: Similarity
messages: Belongs to the FAM32 family.

61853:BABAM1
gene id: 61853:BABAM1
uniprot id: G1R146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

61853:HS3ST2
gene id: 61853:HS3ST2
uniprot id: A0A2I3FS76
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:ADH4
gene id: 61853:ADH4
uniprot id: G1RUJ0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

61853:SRP14
gene id: 61853:SRP14
uniprot id: A0A2I3G2F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

61853:MALL
gene id: 61853:MALL
uniprot id: A0A2I3FXI9
names: Subcellular Location Annotation
messages: Membrane

61853:RABGGTA
gene id: 61853:RABGGTA
uniprot id: A0A2I3GT84
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

61853:LOC100600529
gene id: 61853:LOC100600529
uniprot id: G1SCA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ADGRB3
gene id: 61853:ADGRB3
uniprot id: G1QI60
names: Subcellular Location Annotation
messages: Membrane

61853:CMPK1
gene id: 61853:CMPK1
uniprot id: G1S2X9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

61853:DCTPP1
gene id: 61853:DCTPP1
uniprot id: G1S118
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

61853:PCSK9
gene id: 61853:PCSK9
uniprot id: G1RWX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Cell surface
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Endosome
messages: Golgi apparatus
messages: Lysosome

61853:RBM5
gene id: 61853:RBM5
uniprot id: A0A2I3G2U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

61853:ASB1
gene id: 61853:ASB1
uniprot id: G1RKM3
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:GNAT3
gene id: 61853:GNAT3
uniprot id: G1RX93
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61853:TAS2R50
gene id: 61853:TAS2R50
uniprot id: G1SA71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61853:IST1
gene id: 61853:IST1
uniprot id: A0A2I3G144
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

61853:ITPRIPL1
gene id: 61853:ITPRIPL1
uniprot id: A0A2I3G6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

61853:GORASP1
gene id: 61853:GORASP1
uniprot id: A0A2I3HNG8
uniprot id: G1R0J9
names: Similarity
messages: Belongs to the GORASP family.

61853:MAP1LC3B
gene id: 61853:MAP1LC3B
uniprot id: G1RLA3
names: Similarity
messages: Belongs to the ATG8 family.

61853:APIP
gene id: 61853:APIP
uniprot id: A0A2I3GH41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

61853:LOC100588482
gene id: 61853:LOC100588482
uniprot id: A0A080YV12
uniprot id: A0A2I3H6E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Interacts with ASTL.
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
messages: acrosome membrane

61853:RPE65
gene id: 61853:RPE65
uniprot id: G1RDQ9
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

61853:ATP1B4
gene id: 61853:ATP1B4
uniprot id: G1RY69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

61853:PTEN
gene id: 61853:PTEN
uniprot id: G1RNC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.
messages: Belongs to the PTEN phosphatase protein family.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Postsynaptic density
messages: dendritic spine

61853:TLR1
gene id: 61853:TLR1
uniprot id: G1S5C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

61853:LOC100602226
gene id: 61853:LOC100602226
uniprot id: A0A2I3HMC1
uniprot id: G1RRG3
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:FBLL1
gene id: 61853:FBLL1
uniprot id: A0A2I3HLU0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

61853:ZDHHC3
gene id: 61853:ZDHHC3
uniprot id: A0A2I3HE14
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:ITGB1
gene id: 61853:ITGB1
uniprot id: G1S945
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Cell surface
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

61853:MYLK4
gene id: 61853:MYLK4
uniprot id: G1RJ43
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:GSTM2
gene id: 61853:GSTM2
uniprot id: A0A2I3GHY1
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

61853:ATG13
gene id: 61853:ATG13
uniprot id: A0A2I3HDI4
uniprot id: A0A2I3HZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

61853:RAB9B
gene id: 61853:RAB9B
uniprot id: G1S9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

61853:GCFC2
gene id: 61853:GCFC2
uniprot id: A0A2I3HCE9
names: Similarity
messages: Belongs to the GCF family.

61853:NSRP1
gene id: 61853:NSRP1
uniprot id: G1QTX9
names: Similarity
messages: Belongs to the NSRP1 family.

61853:GTPBP4
gene id: 61853:GTPBP4
uniprot id: A0A2I3HCH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

61853:ARL6
gene id: 61853:ARL6
uniprot id: A0A2I3FYK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

61853:PRRT1
gene id: 61853:PRRT1
uniprot id: G1R473
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:IPO7
gene id: 61853:IPO7
uniprot id: G1S728
names: Subcellular Location Annotation
messages: Cytoplasm

61853:DPH6
gene id: 61853:DPH6
uniprot id: A0A2I3H740
uniprot id: A0A2I3HI86
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

61853:RNF175
gene id: 61853:RNF175
uniprot id: G1R235
names: Subcellular Location Annotation
messages: Membrane

61853:PSME3IP1
gene id: 61853:PSME3IP1
uniprot id: G1QQV5
names: Subcellular Location Annotation
messages: Nucleus

61853:RRAGD
gene id: 61853:RRAGD
uniprot id: G1RRV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

61853:SULT1C4
gene id: 61853:SULT1C4
uniprot id: G1RJ62
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:LOC100596642
gene id: 61853:LOC100596642
uniprot id: G1R7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

61853:PF4V1
gene id: 61853:PF4V1
uniprot id: G1R8X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:GNPNAT1
gene id: 61853:GNPNAT1
uniprot id: A0A2I3H4V7
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

61853:SERPINB9
gene id: 61853:SERPINB9
uniprot id: A0A2I3HQX0
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

61853:MYOZ1
gene id: 61853:MYOZ1
uniprot id: G1S450
names: Similarity
messages: Belongs to the myozenin family.

61853:GLRA3
gene id: 61853:GLRA3
uniprot id: A0A2I3FZL0
uniprot id: G1R4P9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

61853:MSL3
gene id: 61853:MSL3
uniprot id: G1RCV6
names: Subcellular Location Annotation
messages: Nucleus

61853:SNX31
gene id: 61853:SNX31
uniprot id: G1QS75
names: Similarity
messages: Belongs to the sorting nexin family.

61853:VRK1
gene id: 61853:VRK1
uniprot id: G1QIR9
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:NTRK2
gene id: 61853:NTRK2
uniprot id: G1QU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

61853:VOPP1
gene id: 61853:VOPP1
uniprot id: G1RBC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
messages: Membrane

61853:PAIP2
gene id: 61853:PAIP2
uniprot id: G1RD29
names: Similarity
messages: Belongs to the PAIP2 family.

61853:MRAP
gene id: 61853:MRAP
uniprot id: G1QU03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:THAP1
gene id: 61853:THAP1
uniprot id: G1RR39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

61853:ERBB3
gene id: 61853:ERBB3
uniprot id: G1S724
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

61853:LYPLA1
gene id: 61853:LYPLA1
uniprot id: G1QJY8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

61853:SLC45A3
gene id: 61853:SLC45A3
uniprot id: G1RWS9
names: Subcellular Location Annotation
messages: Membrane

61853:PPP1R9A
gene id: 61853:PPP1R9A
uniprot id: G1S0K7
names: Subcellular Location Annotation
messages: cytoskeleton

61853:LOC100596162
gene id: 61853:LOC100596162
uniprot id: G1S3Y7
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

61853:RNF182
gene id: 61853:RNF182
uniprot id: G1QJI1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

61853:SNRPC
gene id: 61853:SNRPC
uniprot id: A0A2I3HAU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

61853:INSL4
gene id: 61853:INSL4
uniprot id: G1RCJ2
names: Subcellular Location Annotation
messages: Secreted

61853:PPP1R3B
gene id: 61853:PPP1R3B
uniprot id: A0A2I3HE44
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

61853:GDF7
gene id: 61853:GDF7
uniprot id: G1QQG7
names: Similarity
messages: Belongs to the TGF-beta family.

61853:GABRR3
gene id: 61853:GABRR3
uniprot id: G1QNS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:GLIPR1L1
gene id: 61853:GLIPR1L1
uniprot id: A0A2I3GBQ7
uniprot id: G1QXC1
names: Similarity
messages: Belongs to the CRISP family.

61853:TLR4
gene id: 61853:TLR4
uniprot id: A0A2I3FXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61853:PAX7
gene id: 61853:PAX7
uniprot id: G1R8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61853:NPVF
gene id: 61853:NPVF
uniprot id: G1RY10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

61853:GJA4
gene id: 61853:GJA4
uniprot id: A0A654IDH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:PRRX1
gene id: 61853:PRRX1
uniprot id: A0A2I3HUB8
names: Subcellular Location Annotation
messages: Nucleus

61853:SMAGP
gene id: 61853:SMAGP
uniprot id: G1S7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAGP family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

61853:HPSE2
gene id: 61853:HPSE2
uniprot id: A0A2I3HML9
uniprot id: G1RWP8
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

61853:SYP
gene id: 61853:SYP
uniprot id: G1R9A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane
messages: synaptic vesicle membrane
messages: synaptosome

61853:C22AH2orf88
gene id: 61853:C22AH2orf88
uniprot id: G1R4G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

61853:STAC
gene id: 61853:STAC
uniprot id: G1QY77
names: Subcellular Location Annotation
messages: sarcolemma

61853:LOC100605241
gene id: 61853:LOC100605241
uniprot id: G1S9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:EMC3
gene id: 61853:EMC3
uniprot id: A0A2I3HHM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

61853:GALNT1
gene id: 61853:GALNT1
uniprot id: G1R326
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:SPTY2D1
gene id: 61853:SPTY2D1
uniprot id: G1S7V8
names: Similarity
messages: Belongs to the SPT2 family.

61853:STRN3
gene id: 61853:STRN3
uniprot id: A0A2I3HXE7
uniprot id: M3Z9C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

61853:BRS3
gene id: 61853:BRS3
uniprot id: G1QQU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

61853:GSTK1
gene id: 61853:GSTK1
uniprot id: A0A2I3G4I9
uniprot id: A0A2I3HMT9
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

61853:NPY1R
gene id: 61853:NPY1R
uniprot id: G1R3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ACBD5
gene id: 61853:ACBD5
uniprot id: A0A2I3GU90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane
messages: Peroxisome membrane

61853:IMMT
gene id: 61853:IMMT
uniprot id: G1QQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

61853:SEPHS1
gene id: 61853:SEPHS1
uniprot id: A0A2I3HGA9
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

61853:LOC100591859
gene id: 61853:LOC100591859
uniprot id: G1SAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:GSTA4
gene id: 61853:GSTA4
uniprot id: G1QTY7
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61853:UTP6
gene id: 61853:UTP6
uniprot id: A0A2I3HCI7
names: Similarity
messages: Belongs to the UTP6 family.

61853:SAMHD1
gene id: 61853:SAMHD1
uniprot id: H6WEA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

61853:SAA1
gene id: 61853:SAA1
uniprot id: G1S7R2
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

61853:SIRT5
gene id: 61853:SIRT5
uniprot id: A0A2I3GHD2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

61853:SDR16C5
gene id: 61853:SDR16C5
uniprot id: G1QKS8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:SYNE4
gene id: 61853:SYNE4
uniprot id: G1RLL8
names: Similarity
messages: Belongs to the nesprin family.

61853:CHRM1
gene id: 61853:CHRM1
uniprot id: A0A2I3G6E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

61853:STMN4
gene id: 61853:STMN4
uniprot id: A0A2I3FQR6
uniprot id: A0A2I3G8B5
uniprot id: A0A2I3HSE2
names: Similarity
messages: Belongs to the stathmin family.

61853:SLC25A37
gene id: 61853:SLC25A37
uniprot id: G1S1G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:CARTPT
gene id: 61853:CARTPT
uniprot id: G1QWY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

61853:RBX1
gene id: 61853:RBX1
uniprot id: A0A2I3GXJ6
names: Similarity
messages: Belongs to the RING-box family.

61853:SPSB4
gene id: 61853:SPSB4
uniprot id: G1QX22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

61853:PRPF38B
gene id: 61853:PRPF38B
uniprot id: G1QM59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

61853:RPL31
gene id: 61853:RPL31
uniprot id: A0A2I3H4T1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

61853:MRPL37
gene id: 61853:MRPL37
uniprot id: G1QT17
names: Subcellular Location Annotation
messages: Mitochondrion

61853:FZD9
gene id: 61853:FZD9
uniprot id: G1SAN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

61853:HSD3B2
gene id: 61853:HSD3B2
uniprot id: A0A2I3G3G6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61853:CES3
gene id: 61853:CES3
uniprot id: A0A2I3HBM5
uniprot id: G1QVY9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

61853:SLC25A46
gene id: 61853:SLC25A46
uniprot id: A0A2I3G9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

61853:ABITRAM
gene id: 61853:ABITRAM
uniprot id: G1S6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABITRAM family.
messages: growth cone
messages: lamellipodium

61853:LAPTM4A
gene id: 61853:LAPTM4A
uniprot id: G1QPS8
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

61853:ACAT2
gene id: 61853:ACAT2
uniprot id: G1RK09
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61853:ATP5PD
gene id: 61853:ATP5PD
uniprot id: G1QIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

61853:STMN1
gene id: 61853:STMN1
uniprot id: G1RD61
names: Similarity
messages: Belongs to the stathmin family.

61853:ASPN
gene id: 61853:ASPN
uniprot id: G1S364
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

61853:CEP70
gene id: 61853:CEP70
uniprot id: G1QWB0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.
messages: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
messages: centrosome

61853:LOC100588416
gene id: 61853:LOC100588416
uniprot id: G1S9J2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:ARMC1
gene id: 61853:ARMC1
uniprot id: G1QUX6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.
messages: Membrane
messages: Mitochondrion outer membrane

61853:CIAO2A
gene id: 61853:CIAO2A
uniprot id: A0A2I3GWM9
names: Similarity
messages: Belongs to the MIP18 family.

61853:PSMB2
gene id: 61853:PSMB2
uniprot id: A0A2I3HJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:GPR107
gene id: 61853:GPR107
uniprot id: G1S7G3
names: Subcellular Location Annotation
messages: Membrane

61853:KIF20B
gene id: 61853:KIF20B
uniprot id: G1RP63
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:LOC100603491
gene id: 61853:LOC100603491
uniprot id: G1S9K3
names: Subcellular Location Annotation
messages: Membrane

61853:NDUFAF7
gene id: 61853:NDUFAF7
uniprot id: A0A2I3HG06
uniprot id: A0A2I3HTN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

61853:ASIC4
gene id: 61853:ASIC4
uniprot id: G1REC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
messages: Membrane

61853:LOC100582711
gene id: 61853:LOC100582711
uniprot id: H9HA59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SERINC1
gene id: 61853:SERINC1
uniprot id: M3ZAQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

61853:PSMC1
gene id: 61853:PSMC1
uniprot id: G1S597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

61853:GTF2A1L
gene id: 61853:GTF2A1L
uniprot id: A0A2I3G894
uniprot id: A0A2I3HC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

61853:GAB3
gene id: 61853:GAB3
uniprot id: G1RVW5
names: Similarity
messages: Belongs to the GAB family.

61853:LOC100602030
gene id: 61853:LOC100602030
uniprot id: A0A2I3HVY4
names: Similarity
messages: Belongs to the syntaxin family.

61853:ST6GALNAC3
gene id: 61853:ST6GALNAC3
uniprot id: A0A2I3FZP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:CPSF3
gene id: 61853:CPSF3
uniprot id: A0A2I3G999
uniprot id: M3Z9C6
names: Subcellular Location Annotation
messages: Nucleus

61853:CHRNA10
gene id: 61853:CHRNA10
uniprot id: G1S642
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:MS4A1
gene id: 61853:MS4A1
uniprot id: A0A2I3GK71
names: Similarity
messages: Belongs to the MS4A family.

61853:ETFRF1
gene id: 61853:ETFRF1
uniprot id: G1QZI7
names: Similarity
messages: Belongs to the complex I LYR family.

61853:PTH
gene id: 61853:PTH
uniprot id: G1S7I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Interacts with PTH1R (via N-terminal extracellular domain).
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
messages: Secreted

61853:PRSS16
gene id: 61853:PRSS16
uniprot id: G1QWP6
names: Similarity
messages: Belongs to the peptidase S28 family.

61853:GPAT3
gene id: 61853:GPAT3
uniprot id: A0A2I3G5Z7
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

61853:NAA25
gene id: 61853:NAA25
uniprot id: G1QGM0
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

61853:NR1H4
gene id: 61853:NR1H4
uniprot id: G1R2I6
uniprot id: G1R2J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61853:LOC100606648
gene id: 61853:LOC100606648
uniprot id: A0A2I3GJ91
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:SLC12A5
gene id: 61853:SLC12A5
uniprot id: A0A2I3G4J5
uniprot id: A0A2I3GCQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61853:ITIH2
gene id: 61853:ITIH2
uniprot id: G1RMH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61853:AURKA
gene id: 61853:AURKA
uniprot id: G1R5V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

61853:URGCP
gene id: 61853:URGCP
uniprot id: A0A2I3H1N0
uniprot id: A0A2I3HGF7
uniprot id: G1QT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

61853:NEO1
gene id: 61853:NEO1
uniprot id: A0A2I3GTR8
uniprot id: A0A2I3HW62
uniprot id: G1RVI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

61853:TSPYL2
gene id: 61853:TSPYL2
uniprot id: G1S1B9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61853:VGLL1
gene id: 61853:VGLL1
uniprot id: G1QR45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

61853:SAR1A
gene id: 61853:SAR1A
uniprot id: G1RKD3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

61853:SLBP
gene id: 61853:SLBP
uniprot id: A0A2I3HBW8
names: Similarity
messages: Belongs to the SLBP family.

61853:EIF3G
gene id: 61853:EIF3G
uniprot id: G1RN66
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

61853:FLT4
gene id: 61853:FLT4
uniprot id: G1QQ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Nucleus

61853:RPL9
gene id: 61853:RPL9
uniprot id: G1S5I0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

61853:ZDHHC9
gene id: 61853:ZDHHC9
uniprot id: G1RZ33
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:TSPYL1
gene id: 61853:TSPYL1
uniprot id: G1SBV2
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61853:ZMYND10
gene id: 61853:ZMYND10
uniprot id: G1R5R8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

61853:TMEM200A
gene id: 61853:TMEM200A
uniprot id: A0A2I3HHI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

61853:SNX17
gene id: 61853:SNX17
uniprot id: G1QTR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

61853:BBS4
gene id: 61853:BBS4
uniprot id: G1RV52
uniprot id: G1RV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS4 family.
messages: Membrane
messages: centrosome
messages: cilium membrane

61853:DBNL
gene id: 61853:DBNL
uniprot id: A0A2I3HIT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

61853:COQ4
gene id: 61853:COQ4
uniprot id: G1S722
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

61853:MAF
gene id: 61853:MAF
uniprot id: G1RHH6
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

61853:TMEM255A
gene id: 61853:TMEM255A
uniprot id: A0A2I3HCV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

61853:CCDC90B
gene id: 61853:CCDC90B
uniprot id: G1S3F0
names: Similarity
messages: Belongs to the CCDC90 family.

61853:LOC100593228
gene id: 61853:LOC100593228
uniprot id: A0A2I3HNU0
uniprot id: G1QVD1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:RTN4IP1
gene id: 61853:RTN4IP1
uniprot id: G1RSG7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61853:EVX1
gene id: 61853:EVX1
uniprot id: G1RYA8
names: Subcellular Location Annotation
messages: Nucleus

61853:MAPK1IP1L
gene id: 61853:MAPK1IP1L
uniprot id: A0A2I3GI94
names: Similarity
messages: Belongs to the MISS family.

61853:CCM2
gene id: 61853:CCM2
uniprot id: G1QVN9
names: Similarity
messages: Belongs to the CCM2 family.

61853:CA3
gene id: 61853:CA3
uniprot id: G1QRJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

61853:BARHL2
gene id: 61853:BARHL2
uniprot id: G1RH20
names: Subcellular Location Annotation
messages: Nucleus

61853:NDUFAB1
gene id: 61853:NDUFAB1
uniprot id: A0A2I3G5C2
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

61853:NDUFB4
gene id: 61853:NDUFB4
uniprot id: G1R832
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:VAMP5
gene id: 61853:VAMP5
uniprot id: A0A2I3GN55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61853:LIPH
gene id: 61853:LIPH
uniprot id: A0A2I3G2Y8
uniprot id: G1R3W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61853:SLC2A11
gene id: 61853:SLC2A11
uniprot id: A0A2I3GEW4
uniprot id: A0A2I3HVA2
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61853:PEX19
gene id: 61853:PEX19
uniprot id: G1RTA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

61853:LLPH
gene id: 61853:LLPH
uniprot id: A0A2I3HI64
names: Similarity
messages: Belongs to the learning-associated protein family.

61853:LEP
gene id: 61853:LEP
uniprot id: G1RNX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

61853:TSHB
gene id: 61853:TSHB
uniprot id: G1QYI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

61853:BTC
gene id: 61853:BTC
uniprot id: G1R905
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:DPP4
gene id: 61853:DPP4
uniprot id: G1QQ71
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

61853:NME4
gene id: 61853:NME4
uniprot id: A0A2I3GGB5
uniprot id: G1R9G2
names: Similarity
messages: Belongs to the NDK family.

61853:ONECUT1
gene id: 61853:ONECUT1
uniprot id: G1R460
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61853:SNX5
gene id: 61853:SNX5
uniprot id: A0A2I3H5G5
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

61853:LOC100593892
gene id: 61853:LOC100593892
uniprot id: A0A2I3G0M1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

61853:RBP5
gene id: 61853:RBP5
uniprot id: G1QZ80
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:FAM110C
gene id: 61853:FAM110C
uniprot id: G1RA72
names: Similarity
messages: Belongs to the FAM110 family.

61853:PMS1
gene id: 61853:PMS1
uniprot id: G1R4F4
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

61853:PIWIL3
gene id: 61853:PIWIL3
uniprot id: G1R819
names: Similarity
messages: Belongs to the argonaute family.

61853:ANTKMT
gene id: 61853:ANTKMT
uniprot id: A0A2I3HV38
uniprot id: G1R9Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

61853:ND5
gene id: 61853:ND5
uniprot id: S4UWB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

61853:LIN28A
gene id: 61853:LIN28A
uniprot id: A0A2I3GBC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

61853:C4H11orf68
gene id: 61853:C4H11orf68
uniprot id: A0A2I3HVD2
names: Similarity
messages: Belongs to the UPF0696 family.

61853:SLC66A3
gene id: 61853:SLC66A3
uniprot id: G1RUX0
names: Subcellular Location Annotation
messages: Membrane

61853:SLC30A6
gene id: 61853:SLC30A6
uniprot id: A0A2I3H1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61853:KCND3
gene id: 61853:KCND3
uniprot id: A0A2I3GHZ2
uniprot id: G1QVI2
names: Subcellular Location Annotation
messages: Membrane
messages: dendrite

61853:COPS5
gene id: 61853:COPS5
uniprot id: G1RJ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

61853:ODF2
gene id: 61853:ODF2
uniprot id: G1S747
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

61853:ALB
gene id: 61853:ALB
uniprot id: A0A2I3H4J6
names: Subcellular Location Annotation
messages: Secreted

61853:PLXNC1
gene id: 61853:PLXNC1
uniprot id: G1R179
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MEIS2
gene id: 61853:MEIS2
uniprot id: A0A2I3I028
uniprot id: G1RKN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

61853:LOC100591902
gene id: 61853:LOC100591902
uniprot id: G1QV55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:TECR
gene id: 61853:TECR
uniprot id: G1RTP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:EBPL
gene id: 61853:EBPL
uniprot id: A0A2I3GKR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:NODAL
gene id: 61853:NODAL
uniprot id: G1S215
names: Similarity
messages: Belongs to the TGF-beta family.

61853:MRGPRE
gene id: 61853:MRGPRE
uniprot id: W8W3P7
names: Subcellular Location Annotation
messages: Cell membrane

61853:CFAP36
gene id: 61853:CFAP36
uniprot id: A0A2I3HQF6
names: Similarity
messages: Belongs to the CFAP36 family.

61853:CLPS
gene id: 61853:CLPS
uniprot id: A0A2I3GYE7
uniprot id: G1RBW5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

61853:SRSF4
gene id: 61853:SRSF4
uniprot id: G1RFU0
names: Similarity
messages: Belongs to the splicing factor SR family.

61853:STAT2
gene id: 61853:STAT2
uniprot id: G1S6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61853:KCNG1
gene id: 61853:KCNG1
uniprot id: G1R5R7
names: Subcellular Location Annotation
messages: Membrane

61853:ASPHD1
gene id: 61853:ASPHD1
uniprot id: G1R7R7
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

61853:IZUMO1
gene id: 61853:IZUMO1
uniprot id: G1QXF7
names: Similarity
messages: Belongs to the Izumo family.

61853:PYCR2
gene id: 61853:PYCR2
uniprot id: A0A2I3G384
uniprot id: G1RTY9
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61853:PSKH1
gene id: 61853:PSKH1
uniprot id: G1QYP3
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:HSBP1
gene id: 61853:HSBP1
uniprot id: A0A2I3HE30
names: Similarity
messages: Belongs to the HSBP1 family.

61853:NLRP4
gene id: 61853:NLRP4
uniprot id: G1RIF5
names: Similarity
messages: Belongs to the NLRP family.

61853:TAF1B
gene id: 61853:TAF1B
uniprot id: G1RTC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

61853:LYZ
gene id: 61853:LYZ
uniprot id: G1QUK3
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

61853:IRF8
gene id: 61853:IRF8
uniprot id: G1RL04
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:ZC3HC1
gene id: 61853:ZC3HC1
uniprot id: G1RQB1
names: Subcellular Location Annotation
messages: Nucleus

61853:PIGP
gene id: 61853:PIGP
uniprot id: G1QX25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

61853:NKX3-1
gene id: 61853:NKX3-1
uniprot id: A0A2I3GI44
uniprot id: A0A2I3HD46
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100596228
gene id: 61853:LOC100596228
uniprot id: G1RYY5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:TIMP4
gene id: 61853:TIMP4
uniprot id: G1QXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

61853:ARID5B
gene id: 61853:ARID5B
uniprot id: A0A2I3GU13
uniprot id: A0A2I3H250
names: Similarity
messages: Belongs to the ARID5B family.

61853:ATP5F1C
gene id: 61853:ATP5F1C
uniprot id: A0A2I3GAS6
uniprot id: G1RMQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

61853:CPLX3
gene id: 61853:CPLX3
uniprot id: A0A2I3HHZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61853:RPL28
gene id: 61853:RPL28
uniprot id: A0A2I3H9Q1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

61853:EIF4ENIF1
gene id: 61853:EIF4ENIF1
uniprot id: A0A2I3H6U7
names: Subcellular Location Annotation
messages: Cytoplasm

61853:CASP2
gene id: 61853:CASP2
uniprot id: G1QSD1
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:LDHAL6A
gene id: 61853:LDHAL6A
uniprot id: G1S7V3
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

61853:IMMP1L
gene id: 61853:IMMP1L
uniprot id: G1S888
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

61853:SPESP1
gene id: 61853:SPESP1
uniprot id: G1RSK0
names: Function
names: Similarity
messages: Belongs to the SPESP1 family.
messages: Involved in fertilization ability of sperm.

61853:LSM2
gene id: 61853:LSM2
uniprot id: A0A2I3GHD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

61853:RALA
gene id: 61853:RALA
uniprot id: G1QRZ8
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

61853:PFKFB4
gene id: 61853:PFKFB4
uniprot id: A0A2I3HHQ8
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

61853:USP3
gene id: 61853:USP3
uniprot id: G1RNW6
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61853:LOC100582529
gene id: 61853:LOC100582529
uniprot id: G1S6C7
names: Similarity
messages: Belongs to the globin family.

61853:TAF8
gene id: 61853:TAF8
uniprot id: A0A2I3HRU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

61853:GCNT1
gene id: 61853:GCNT1
uniprot id: A0A2I3GQ26
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61853:EMC8
gene id: 61853:EMC8
uniprot id: A0A2I3HUR7
uniprot id: G1RKV5
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

61853:SELL
gene id: 61853:SELL
uniprot id: A0A2I3H1K0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:RAP2B
gene id: 61853:RAP2B
uniprot id: A0A2I3H298
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

61853:ASZ1
gene id: 61853:ASZ1
uniprot id: Q07DX6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

61853:YWHAZ
gene id: 61853:YWHAZ
uniprot id: A0A2I3GBB0
names: Similarity
messages: Belongs to the 14-3-3 family.

61853:CLCN4
gene id: 61853:CLCN4
uniprot id: G1RCA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

61853:RNF13
gene id: 61853:RNF13
uniprot id: G1QSD2
names: Subcellular Location Annotation
messages: Membrane

61853:PTGFR
gene id: 61853:PTGFR
uniprot id: G1RFF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ABCG8
gene id: 61853:ABCG8
uniprot id: G1S4D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61853:BCL9
gene id: 61853:BCL9
uniprot id: A0A2I3HDY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

61853:GPR3
gene id: 61853:GPR3
uniprot id: A0A2I3GEV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SMIM12
gene id: 61853:SMIM12
uniprot id: G1S9B7
uniprot id: G1S9B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM12 family.
messages: Membrane

61853:ATP5MG
gene id: 61853:ATP5MG
uniprot id: G1R710
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

61853:IMPDH2
gene id: 61853:IMPDH2
uniprot id: G1R4U5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

61853:TADA1
gene id: 61853:TADA1
uniprot id: G1RXH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

61853:RGS4
gene id: 61853:RGS4
uniprot id: G1RX06
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

61853:GINS1
gene id: 61853:GINS1
uniprot id: G1S0I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

61853:FAM135A
gene id: 61853:FAM135A
uniprot id: A0A2I3HC22
uniprot id: A0A2I3HG02
names: Similarity
messages: Belongs to the FAM135 family.

61853:LOC100598627
gene id: 61853:LOC100598627
uniprot id: G1S0N3
names: Similarity
messages: Belongs to the SGT1 family.

61853:CACNG2
gene id: 61853:CACNG2
uniprot id: G1RX54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

61853:ARHGEF2
gene id: 61853:ARHGEF2
uniprot id: A0A2I3HHZ2
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Golgi apparatus
messages: Vesicle
messages: spindle
messages: tight junction

61853:EIF3I
gene id: 61853:EIF3I
uniprot id: G1QPS5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated by TGF-beta type II receptor.

61853:GDAP2
gene id: 61853:GDAP2
uniprot id: G1QZN2
names: Similarity
messages: Belongs to the GDAP2 family.

61853:LOC100605653
gene id: 61853:LOC100605653
uniprot id: A0A2I3HS95
names: Similarity
messages: Belongs to the SPT20 family.

61853:CASP8
gene id: 61853:CASP8
uniprot id: A0A2I3GJU5
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:SGK1
gene id: 61853:SGK1
uniprot id: A0A2I3GN77
uniprot id: A0A2I3H0Z4
uniprot id: G1RXA9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

61853:B3GALNT2
gene id: 61853:B3GALNT2
uniprot id: A0A2I3GA48
uniprot id: G1QRM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:PIK3R2
gene id: 61853:PIK3R2
uniprot id: G1R1V3
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

61853:GNPAT
gene id: 61853:GNPAT
uniprot id: G1QNI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

61853:SLC22A4
gene id: 61853:SLC22A4
uniprot id: G1RQ89
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

61853:RAP2A
gene id: 61853:RAP2A
uniprot id: G1R8I3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

61853:TRPV1
gene id: 61853:TRPV1
uniprot id: A0A2I3HJR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendritic spine membrane

61853:CD163L1
gene id: 61853:CD163L1
uniprot id: G1QZM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100590716
gene id: 61853:LOC100590716
uniprot id: A0A2I3GI08
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

61853:NPPB
gene id: 61853:NPPB
uniprot id: G1RF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

61853:EVA1A
gene id: 61853:EVA1A
uniprot id: G1QK85
names: Similarity
messages: Belongs to the EVA1 family.

61853:GK
gene id: 61853:GK
uniprot id: A0A2I3FWY7
uniprot id: A0A2I3HMK9
uniprot id: G1RGH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

61853:NLGN1
gene id: 61853:NLGN1
uniprot id: G1R0S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

61853:FCER1G
gene id: 61853:FCER1G
uniprot id: A0A2I3GZ40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

61853:MAK16
gene id: 61853:MAK16
uniprot id: A0A2I3GTD6
names: Similarity
messages: Belongs to the MAK16 family.

61853:EFHC1
gene id: 61853:EFHC1
uniprot id: A0A2I3GWC5
names: Subcellular Location Annotation
messages: cilium axoneme

61853:PROZ
gene id: 61853:PROZ
uniprot id: G1QI89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:DENND10
gene id: 61853:DENND10
uniprot id: A0A2I3GS96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

61853:MICOS10
gene id: 61853:MICOS10
uniprot id: G1R8Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

61853:HAMP
gene id: 61853:HAMP
uniprot id: G1RJV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

61853:PMP22
gene id: 61853:PMP22
uniprot id: G1RX87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.

61853:PFDN6
gene id: 61853:PFDN6
uniprot id: A0A2I3HQ15
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

61853:TSPO2
gene id: 61853:TSPO2
uniprot id: G1QYW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

61853:NEDD9
gene id: 61853:NEDD9
uniprot id: G1QIS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61853:UBE2L5
gene id: 61853:UBE2L5
uniprot id: G1SAJ3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:LOC100600563
gene id: 61853:LOC100600563
uniprot id: A0A2I3G2E1
uniprot id: G1RDM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61853:OXSR1
gene id: 61853:OXSR1
uniprot id: G1QZY4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

61853:TBCD
gene id: 61853:TBCD
uniprot id: G1RIG4
names: Similarity
messages: Belongs to the TBCD family.

61853:LOC100589670
gene id: 61853:LOC100589670
uniprot id: G1SCC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:EFNA4
gene id: 61853:EFNA4
uniprot id: A0A2I3HET1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:PAGE2B
gene id: 61853:PAGE2B
uniprot id: G1S2S0
names: Similarity
messages: Belongs to the GAGE family.

61853:BCAP31
gene id: 61853:BCAP31
uniprot id: G1RSQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

61853:CUEDC2
gene id: 61853:CUEDC2
uniprot id: A0A2I3GD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

61853:SERPINA11
gene id: 61853:SERPINA11
uniprot id: G1S648
names: Similarity
messages: Belongs to the serpin family.

61853:RPS27
gene id: 61853:RPS27
uniprot id: A0A2I3GMQ8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61853:F13B
gene id: 61853:F13B
uniprot id: G1S8U8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LIN54
gene id: 61853:LIN54
uniprot id: A0A2I3HBB7
uniprot id: A0A2I3HIB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

61853:HAO2
gene id: 61853:HAO2
uniprot id: G1QZY8
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

61853:MFF
gene id: 61853:MFF
uniprot id: A0A2I3GG28
uniprot id: A0A2I3GLD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tango11 family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
messages: synaptic vesicle

61853:CKS2
gene id: 61853:CKS2
uniprot id: A0A2I3H505
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

61853:GADD45G
gene id: 61853:GADD45G
uniprot id: G1QHZ9
names: Similarity
messages: Belongs to the GADD45 family.

61853:SLC25A22
gene id: 61853:SLC25A22
uniprot id: G1RB98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:VPS37A
gene id: 61853:VPS37A
uniprot id: A0A2I3GTP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61853:MMP12
gene id: 61853:MMP12
uniprot id: G1R6D8
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:ATP6AP1
gene id: 61853:ATP6AP1
uniprot id: G1RVI5
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

61853:EPHA10
gene id: 61853:EPHA10
uniprot id: A0A2I3GM05
names: Subcellular Location Annotation
messages: Membrane

61853:SPINK4
gene id: 61853:SPINK4
uniprot id: G1QZD1
names: Subcellular Location Annotation
messages: Secreted

61853:HHIPL2
gene id: 61853:HHIPL2
uniprot id: G1RTU4
names: Similarity
messages: Belongs to the HHIP family.

61853:DDX4
gene id: 61853:DDX4
uniprot id: A0A2I3GHS8
uniprot id: A0A2I3GUR4
names: Similarity
messages: Belongs to the DEAD box helicase family.

61853:TBPL1
gene id: 61853:TBPL1
uniprot id: G1RX62
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

61853:SOX14
gene id: 61853:SOX14
uniprot id: G1SBJ0
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100599698
gene id: 61853:LOC100599698
uniprot id: G1S8U7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:GSTO2
gene id: 61853:GSTO2
uniprot id: A0A2I3FYU4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

61853:RNF126
gene id: 61853:RNF126
uniprot id: A0A2I3HQC0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:STMN2
gene id: 61853:STMN2
uniprot id: G1QP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

61853:EDN3
gene id: 61853:EDN3
uniprot id: A0A2I3HE82
uniprot id: A0A2I3HXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

61853:SUMF1
gene id: 61853:SUMF1
uniprot id: G1QT25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

61853:CTNNAL1
gene id: 61853:CTNNAL1
uniprot id: G1S6K3
names: Similarity
messages: Belongs to the vinculin/alpha-catenin family.

61853:UBE2H
gene id: 61853:UBE2H
uniprot id: G1RQ84
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:DISP3
gene id: 61853:DISP3
uniprot id: G1REQ0
names: Subcellular Location Annotation
messages: Membrane

61853:ASB10
gene id: 61853:ASB10
uniprot id: A0A2I3G2M1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:MLF2
gene id: 61853:MLF2
uniprot id: G1QXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

61853:UNC50
gene id: 61853:UNC50
uniprot id: G1QNC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

61853:NCR3
gene id: 61853:NCR3
uniprot id: A0A2I3GFC8
uniprot id: G1R2M3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

61853:DPYSL2
gene id: 61853:DPYSL2
uniprot id: G1S2J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
messages: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.

61853:LIMD1
gene id: 61853:LIMD1
uniprot id: G1R2B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zyxin/ajuba family.
messages: Cytoplasm
messages: Nucleus

61853:PIH1D3
gene id: 61853:PIH1D3
uniprot id: G1RUE5
names: Similarity
messages: Belongs to the PIH1 family.

61853:SAG
gene id: 61853:SAG
uniprot id: A0A2I3H239
names: Similarity
messages: Belongs to the arrestin family.

61853:ESR1
gene id: 61853:ESR1
uniprot id: G1RZN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

61853:MZT1
gene id: 61853:MZT1
uniprot id: G1S1L7
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

61853:ZNF622
gene id: 61853:ZNF622
uniprot id: G1RMH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

61853:USP5
gene id: 61853:USP5
uniprot id: G1QY12
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61853:SELENOO
gene id: 61853:SELENOO
uniprot id: A0A2I3HUH2
names: Similarity
messages: Belongs to the SELO family.

61853:LDHAL6B
gene id: 61853:LDHAL6B
uniprot id: G1SB71
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

61853:CAVIN3
gene id: 61853:CAVIN3
uniprot id: A0A2I3HSB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

61853:GRIA4
gene id: 61853:GRIA4
uniprot id: A0A2I3H1N9
uniprot id: G1R6G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

61853:SLC52A3
gene id: 61853:SLC52A3
uniprot id: G1RE05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

61853:XRCC4
gene id: 61853:XRCC4
uniprot id: E5FGK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

61853:ALKBH2
gene id: 61853:ALKBH2
uniprot id: A0A2I3GRU8
names: Similarity
messages: Belongs to the alkB family.

61853:SPA17
gene id: 61853:SPA17
uniprot id: G1R780
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.

61853:LOC100607684
gene id: 61853:LOC100607684
uniprot id: H9HA54
names: Similarity
messages: Belongs to the FAM76 family.

61853:NIP7
gene id: 61853:NIP7
uniprot id: G1R0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

61853:PPP1R35
gene id: 61853:PPP1R35
uniprot id: G1RM09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP1R35 family.
messages: centriole

61853:EXOSC3
gene id: 61853:EXOSC3
uniprot id: G1QTK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm

61853:PCNA
gene id: 61853:PCNA
uniprot id: G1R863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

61853:EIF5
gene id: 61853:EIF5
uniprot id: A0A2I3G3H3
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

61853:LRRC8C
gene id: 61853:LRRC8C
uniprot id: A0A2I3HQM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

61853:FAM124A
gene id: 61853:FAM124A
uniprot id: A0A2I3HHG8
names: Similarity
messages: Belongs to the FAM124 family.

61853:MPC2
gene id: 61853:MPC2
uniprot id: G1RXY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61853:SPCS1
gene id: 61853:SPCS1
uniprot id: A0A2I3HI38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:OGN
gene id: 61853:OGN
uniprot id: G1S342
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

61853:TMC7
gene id: 61853:TMC7
uniprot id: G1R061
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61853:MRPL32
gene id: 61853:MRPL32
uniprot id: A0A2I3GP56
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

61853:TPPP3
gene id: 61853:TPPP3
uniprot id: G1QXG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

61853:SERPINA7
gene id: 61853:SERPINA7
uniprot id: G1RTN6
names: Similarity
messages: Belongs to the serpin family.

61853:TMEM88
gene id: 61853:TMEM88
uniprot id: G1RFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

61853:FAM216B
gene id: 61853:FAM216B
uniprot id: A0A2I3H932
names: Similarity
messages: Belongs to the FAM216 family.

61853:CNFN
gene id: 61853:CNFN
uniprot id: G1RIE1
names: Similarity
messages: Belongs to the cornifelin family.

61853:PRPF19
gene id: 61853:PRPF19
uniprot id: A0A2I3GKY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

61853:C2H5orf24
gene id: 61853:C2H5orf24
uniprot id: G1R9T0
names: Similarity
messages: Belongs to the UPF0461 family.

61853:PLA2G5
gene id: 61853:PLA2G5
uniprot id: G1R8T9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61853:MRPL51
gene id: 61853:MRPL51
uniprot id: A0A2I3G3J7
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

61853:FGF12
gene id: 61853:FGF12
uniprot id: A0A2I3GG73
uniprot id: G1R4X8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:FAM229A
gene id: 61853:FAM229A
uniprot id: G1QQG0
names: Similarity
messages: Belongs to the FAM229 family.

61853:TRUB2
gene id: 61853:TRUB2
uniprot id: G1S716
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

61853:RTN2
gene id: 61853:RTN2
uniprot id: A0A2I3HPS3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:TDRD3
gene id: 61853:TDRD3
uniprot id: G1S1E6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

61853:FIS1
gene id: 61853:FIS1
uniprot id: A0A2I3H8F2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

61853:ATP6V1F
gene id: 61853:ATP6V1F
uniprot id: A0A2I3HWZ2
uniprot id: G1RPE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61853:ANTXR1
gene id: 61853:ANTXR1
uniprot id: A0A2I3HS32
uniprot id: G1RGD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

61853:NCK1
gene id: 61853:NCK1
uniprot id: G1QVI6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

61853:HMGCS1
gene id: 61853:HMGCS1
uniprot id: A0A2I3GM62
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

61853:MLLT11
gene id: 61853:MLLT11
uniprot id: A0A2I3HR46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

61853:LOC100592883
gene id: 61853:LOC100592883
uniprot id: A0A2I3HH44
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC48A1
gene id: 61853:SLC48A1
uniprot id: G1S8B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
messages: Lysosome membrane
messages: Membrane

61853:BCL2
gene id: 61853:BCL2
uniprot id: A0A2I3GZF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

61853:HM13
gene id: 61853:HM13
uniprot id: A0A2I3HP35
uniprot id: G1REQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

61853:PEA15
gene id: 61853:PEA15
uniprot id: A0A2I3HKB1
names: Subcellular Location Annotation
messages: Cytoplasm

61853:CHRNA3
gene id: 61853:CHRNA3
uniprot id: G1RBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:SDHAF3
gene id: 61853:SDHAF3
uniprot id: G1S1M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

61853:GRIA1
gene id: 61853:GRIA1
uniprot id: A0A2I3H9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

61853:TSSK2
gene id: 61853:TSSK2
uniprot id: G1SC02
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:CCDC85B
gene id: 61853:CCDC85B
uniprot id: A0A2I3HE63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

61853:EGR3
gene id: 61853:EGR3
uniprot id: G1S103
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

61853:NCOA2
gene id: 61853:NCOA2
uniprot id: G1RKR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

61853:IMPACT
gene id: 61853:IMPACT
uniprot id: G1R485
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

61853:ACER2
gene id: 61853:ACER2
uniprot id: G1S6Y4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:RIC3
gene id: 61853:RIC3
uniprot id: A0A2I3H766
names: Similarity
messages: Belongs to the ric-3 family.

61853:LSM7
gene id: 61853:LSM7
uniprot id: G1QP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

61853:PDHX
gene id: 61853:PDHX
uniprot id: G1S8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61853:IER3IP1
gene id: 61853:IER3IP1
uniprot id: G1RL16
names: Similarity
messages: Belongs to the YOS1 family.

61853:C6H5orf22
gene id: 61853:C6H5orf22
uniprot id: G1RUU1
names: Similarity
messages: Belongs to the UPF0489 family.

61853:DIO1
gene id: 61853:DIO1
uniprot id: G1QTE8
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

61853:PPP4C
gene id: 61853:PPP4C
uniprot id: G1QNR3
names: Similarity
messages: Belongs to the PPP phosphatase family.

61853:TRIM2
gene id: 61853:TRIM2
uniprot id: G1R1V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm

61853:SLC25A42
gene id: 61853:SLC25A42
uniprot id: A0A2I3GNQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:P2RY11
gene id: 61853:P2RY11
uniprot id: A0A2I3FUK3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:HLCS
gene id: 61853:HLCS
uniprot id: G1QWZ1
names: Similarity
messages: Belongs to the biotin--protein ligase family.

61853:CSNK1A1
gene id: 61853:CSNK1A1
uniprot id: A0A2I3HMA6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:MINDY1
gene id: 61853:MINDY1
uniprot id: A0A2I3H6Q3
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

61853:LGALS3
gene id: 61853:LGALS3
uniprot id: G1RQN0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Secreted

61853:ICOS
gene id: 61853:ICOS
uniprot id: G1R5Y2
uniprot id: M3ZA37
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

61853:FGGY
gene id: 61853:FGGY
uniprot id: G1RXL6
names: Similarity
messages: Belongs to the FGGY kinase family.

61853:MED30
gene id: 61853:MED30
uniprot id: G1QY76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

61853:FAM172A
gene id: 61853:FAM172A
uniprot id: G1RUH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

61853:EXOC4
gene id: 61853:EXOC4
uniprot id: G1RR97
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61853:RNF112
gene id: 61853:RNF112
uniprot id: G1RC12
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61853:SPIN4
gene id: 61853:SPIN4
uniprot id: G1SAK0
names: Similarity
messages: Belongs to the SPIN/STSY family.

61853:PPP5C
gene id: 61853:PPP5C
uniprot id: A0A2I3GLM2
uniprot id: G1QQU2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

61853:TXNL4A
gene id: 61853:TXNL4A
uniprot id: A0A2I3GR22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

61853:PSMD1
gene id: 61853:PSMD1
uniprot id: G1RUV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

61853:NAB2
gene id: 61853:NAB2
uniprot id: G1S6K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

61853:LOC100595103
gene id: 61853:LOC100595103
uniprot id: G1SC99
names: Subcellular Location Annotation
messages: Membrane

61853:SPON1
gene id: 61853:SPON1
uniprot id: G1S7J0
names: Subcellular Location Annotation
messages: extracellular matrix

61853:CTNND2
gene id: 61853:CTNND2
uniprot id: G1RM42
names: Similarity
messages: Belongs to the beta-catenin family.

61853:TSPAN9
gene id: 61853:TSPAN9
uniprot id: A0A2I3FVE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:CDK2AP2
gene id: 61853:CDK2AP2
uniprot id: G1R3R0
names: Similarity
messages: Belongs to the CDK2AP family.

61853:INKA2
gene id: 61853:INKA2
uniprot id: M3Z931
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

61853:DBNDD2
gene id: 61853:DBNDD2
uniprot id: G1R4Q7
names: Similarity
messages: Belongs to the dysbindin family.

61853:NDUFA5
gene id: 61853:NDUFA5
uniprot id: A0A2I3HMN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:SLC11A2
gene id: 61853:SLC11A2
uniprot id: A0A2I3FTW4
names: Similarity
messages: Belongs to the NRAMP family.

61853:GNRHR
gene id: 61853:GNRHR
uniprot id: G1RD52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:STAG2
gene id: 61853:STAG2
uniprot id: A0A2I3HJY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

61853:CFDP1
gene id: 61853:CFDP1
uniprot id: G1RRE9
names: Function
names: Subcellular Location Annotation
messages: May play a role during embryogenesis.
messages: kinetochore

61853:OAZ3
gene id: 61853:OAZ3
uniprot id: G1RH25
names: Similarity
messages: Belongs to the ODC antizyme family.

61853:CENPL
gene id: 61853:CENPL
uniprot id: A0A2I3HFI8
uniprot id: G1RZ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

61853:FSCN3
gene id: 61853:FSCN3
uniprot id: G1RNR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61853:TMEM233
gene id: 61853:TMEM233
uniprot id: A0A2I3HQG0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:MRPL40
gene id: 61853:MRPL40
uniprot id: G1QZY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

61853:RPL24
gene id: 61853:RPL24
uniprot id: A0A2I3H3Q6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61853:PNN
gene id: 61853:PNN
uniprot id: G1QVI0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pinin family.
messages: Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.
messages: Nucleus speckle
messages: desmosome

61853:GLB1
gene id: 61853:GLB1
uniprot id: G1QX00
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

61853:FLT1
gene id: 61853:FLT1
uniprot id: G1QIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

61853:CD9
gene id: 61853:CD9
uniprot id: G1QTK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

61853:ARL6IP5
gene id: 61853:ARL6IP5
uniprot id: A0A2I3GLS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

61853:NR1H2
gene id: 61853:NR1H2
uniprot id: G1R0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61853:ACAP2
gene id: 61853:ACAP2
uniprot id: A0A2I3HHG2
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

61853:ADPRHL1
gene id: 61853:ADPRHL1
uniprot id: G1QJ39
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

61853:SOX8
gene id: 61853:SOX8
uniprot id: G1RAS9
names: Subcellular Location Annotation
messages: Nucleus

61853:POSTN
gene id: 61853:POSTN
uniprot id: A0A2I3G6X1
uniprot id: A0A2I3GS27
uniprot id: A0A2I3HCB7
uniprot id: A0A2I3HM67
uniprot id: G1QPI1
names: Subcellular Location Annotation
messages: extracellular matrix

61853:DPP3
gene id: 61853:DPP3
uniprot id: G1R2N9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

61853:LAMP3
gene id: 61853:LAMP3
uniprot id: G1R282
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

61853:CLVS1
gene id: 61853:CLVS1
uniprot id: G1QNX3
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

61853:GDE1
gene id: 61853:GDE1
uniprot id: G1RPU6
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61853:TRAPPC6B
gene id: 61853:TRAPPC6B
uniprot id: A0A2I3GQT9
uniprot id: G1QVE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

61853:BCAN
gene id: 61853:BCAN
uniprot id: G1RQD0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:DDC
gene id: 61853:DDC
uniprot id: A0A2I3GGH6
uniprot id: A0A2I3GQN2
uniprot id: A0A2I3HF22
uniprot id: A0A2I3HP61
uniprot id: A0A2I3HRT2
uniprot id: G1RA43
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61853:CDH3
gene id: 61853:CDH3
uniprot id: G1QZQ9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:SERPINA5
gene id: 61853:SERPINA5
uniprot id: G1S667
names: Similarity
messages: Belongs to the serpin family.

61853:ETV5
gene id: 61853:ETV5
uniprot id: G1R425
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:TIPRL
gene id: 61853:TIPRL
uniprot id: G1RY09
names: Similarity
messages: Belongs to the TIP41 family.

61853:MAP4K3
gene id: 61853:MAP4K3
uniprot id: A0A2I3HT86
uniprot id: G1S3J1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

61853:ZSCAN2
gene id: 61853:ZSCAN2
uniprot id: A0A2I3GXF6
uniprot id: A0A2I3GZV9
names: Subcellular Location Annotation
messages: Nucleus

61853:CMAS
gene id: 61853:CMAS
uniprot id: G1QYJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

61853:MRE11
gene id: 61853:MRE11
uniprot id: A0A2I3GFZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

61853:GUCA2B
gene id: 61853:GUCA2B
uniprot id: G1RNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

61853:LOC100581084
gene id: 61853:LOC100581084
uniprot id: A0A2I3GN60
names: Similarity
messages: Belongs to the copine family.

61853:IL10
gene id: 61853:IL10
uniprot id: A0A2I3GRH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

61853:A3GALT2
gene id: 61853:A3GALT2
uniprot id: A0A2I3HMK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

61853:NDUFB5
gene id: 61853:NDUFB5
uniprot id: A0A2I3GGZ9
uniprot id: A0A2I3HSE6
uniprot id: A0A2I3HYD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:MSMP
gene id: 61853:MSMP
uniprot id: G1QVN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

61853:LOC100596916
gene id: 61853:LOC100596916
uniprot id: G1SCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PPBP
gene id: 61853:PPBP
uniprot id: G1R8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:FBLN7
gene id: 61853:FBLN7
uniprot id: G1QLT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PSMB6
gene id: 61853:PSMB6
uniprot id: A0A2I3HD72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:SLAIN1
gene id: 61853:SLAIN1
uniprot id: G1S2Y3
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

61853:NIM1K
gene id: 61853:NIM1K
uniprot id: G1RHG5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:JAKMIP2
gene id: 61853:JAKMIP2
uniprot id: A0A2I3GDX8
uniprot id: A0A2I3HWA0
names: Similarity
messages: Belongs to the JAKMIP family.

61853:NT5C2
gene id: 61853:NT5C2
uniprot id: G1RZ09
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

61853:DIAPH2
gene id: 61853:DIAPH2
uniprot id: G1QJL9
names: Similarity
messages: Belongs to the formin homology family. Diaphanous subfamily.

61853:E2F5
gene id: 61853:E2F5
uniprot id: G1QR80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61853:HOMEZ
gene id: 61853:HOMEZ
uniprot id: A0A2I3HNI3
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC51A
gene id: 61853:SLC51A
uniprot id: G1QL25
names: Subcellular Location Annotation
messages: Membrane

61853:KCTD13
gene id: 61853:KCTD13
uniprot id: M3Z9T1
names: Similarity
messages: Belongs to the BACURD family.

61853:MSANTD3
gene id: 61853:MSANTD3
uniprot id: A0A2I3HLU5
names: Similarity
messages: Belongs to the MSANTD3 family.

61853:DNAJC2
gene id: 61853:DNAJC2
uniprot id: G1RDR8
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Nucleus
messages: cytosol

61853:TRPV5
gene id: 61853:TRPV5
uniprot id: G1QRE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:NPSR1
gene id: 61853:NPSR1
uniprot id: G1RZW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

61853:ELOVL1
gene id: 61853:ELOVL1
uniprot id: A0A2I3GT94
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61853:BANF1
gene id: 61853:BANF1
uniprot id: G1R238
names: Subcellular Location Annotation
messages: Nucleus

61853:IRF5
gene id: 61853:IRF5
uniprot id: A0A2I3GUB4
uniprot id: G1RPJ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:PTPN4
gene id: 61853:PTPN4
uniprot id: G1QJB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

61853:C10H12orf65
gene id: 61853:C10H12orf65
uniprot id: G1QLA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

61853:LOC100589061
gene id: 61853:LOC100589061
uniprot id: G1R3I0
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:CDH10
gene id: 61853:CDH10
uniprot id: G1RMW8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:ANKRD13D
gene id: 61853:ANKRD13D
uniprot id: G1R3E1
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

61853:TLCD4
gene id: 61853:TLCD4
uniprot id: G1RK96
names: Subcellular Location Annotation
messages: Membrane

61853:PAPSS2
gene id: 61853:PAPSS2
uniprot id: G1RNB1
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

61853:RIOK3
gene id: 61853:RIOK3
uniprot id: G1R4W5
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
messages: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.

61853:ZNF397
gene id: 61853:ZNF397
uniprot id: A0A2I3HS82
names: Subcellular Location Annotation
messages: Nucleus

61853:PCNX4
gene id: 61853:PCNX4
uniprot id: G1RTK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

61853:NANOG
gene id: 61853:NANOG
uniprot id: G1RYL3
names: Subcellular Location Annotation
messages: Nucleus

61853:PI4K2A
gene id: 61853:PI4K2A
uniprot id: G1RVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

61853:MIPEP
gene id: 61853:MIPEP
uniprot id: A0A2I3GF84
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

61853:SOAT2
gene id: 61853:SOAT2
uniprot id: G1S7L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:MS4A6E
gene id: 61853:MS4A6E
uniprot id: G1RSH9
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

61853:S100A4
gene id: 61853:S100A4
uniprot id: G1RHG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

61853:LOC100605713
gene id: 61853:LOC100605713
uniprot id: G1SCB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:EIF6
gene id: 61853:EIF6
uniprot id: G1RGU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

61853:MCMBP
gene id: 61853:MCMBP
uniprot id: G1S4C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

61853:C2H5orf63
gene id: 61853:C2H5orf63
uniprot id: G1RNT2
names: Similarity
messages: Belongs to the glutaredoxin family.

61853:CREG1
gene id: 61853:CREG1
uniprot id: G1RXN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

61853:LYG2
gene id: 61853:LYG2
uniprot id: G1QNT8
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

61853:TSG101
gene id: 61853:TSG101
uniprot id: G1S7V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

61853:GABARAP
gene id: 61853:GABARAP
uniprot id: A0A2I3GQ66
names: Similarity
messages: Belongs to the ATG8 family.

61853:NOP53
gene id: 61853:NOP53
uniprot id: G1QT31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

61853:PACSIN2
gene id: 61853:PACSIN2
uniprot id: G1S1U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

61853:OTOP1
gene id: 61853:OTOP1
uniprot id: G1S271
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61853:CD2
gene id: 61853:CD2
uniprot id: G1QZ89
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:PHTF2
gene id: 61853:PHTF2
uniprot id: G1REN2
names: Subcellular Location Annotation
messages: Membrane

61853:ACADSB
gene id: 61853:ACADSB
uniprot id: A0A2I3GXB0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61853:LOC100588553
gene id: 61853:LOC100588553
uniprot id: G1RSS2
names: Similarity
messages: Belongs to the MS4A family.

61853:FGF14
gene id: 61853:FGF14
uniprot id: G1R8L4
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:ERRFI1
gene id: 61853:ERRFI1
uniprot id: G1RBZ6
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

61853:LOC100581638
gene id: 61853:LOC100581638
uniprot id: A0A2I3HRS3
names: Similarity
messages: Belongs to the globin family.

61853:DOCK1
gene id: 61853:DOCK1
uniprot id: G1QIA9
names: Similarity
messages: Belongs to the DOCK family.

61853:LYPD2
gene id: 61853:LYPD2
uniprot id: G1QKT9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:SLC16A3
gene id: 61853:SLC16A3
uniprot id: G1RV25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

61853:HNF4G
gene id: 61853:HNF4G
uniprot id: A0A2I3G374
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61853:KIF23
gene id: 61853:KIF23
uniprot id: G1RT23
uniprot id: M3ZBV8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:TRAF6
gene id: 61853:TRAF6
uniprot id: G1S8G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

61853:TFE3
gene id: 61853:TFE3
uniprot id: G1R928
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61853:LTV1
gene id: 61853:LTV1
uniprot id: G1RYQ7
names: Similarity
messages: Belongs to the LTV1 family.

61853:MRPL23
gene id: 61853:MRPL23
uniprot id: M3ZB80
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

61853:LOC100605698
gene id: 61853:LOC100605698
uniprot id: G1QS41
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:PLP2
gene id: 61853:PLP2
uniprot id: H9H9X1
names: Subcellular Location Annotation
messages: Membrane

61853:VKORC1
gene id: 61853:VKORC1
uniprot id: A0A2I3G0U5
uniprot id: A0A2I3HF76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:GABRA3
gene id: 61853:GABRA3
uniprot id: G1RU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:TOMM20
gene id: 61853:TOMM20
uniprot id: A0A2I3H7P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

61853:RBBP7
gene id: 61853:RBBP7
uniprot id: G1REL4
uniprot id: M3ZB33
names: Subcellular Location Annotation
messages: Nucleus

61853:THNSL1
gene id: 61853:THNSL1
uniprot id: G1S495
names: Similarity
messages: Belongs to the threonine synthase family.

61853:CERS6
gene id: 61853:CERS6
uniprot id: G1QX90
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61853:TMEM161B
gene id: 61853:TMEM161B
uniprot id: A0A2I3HEP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

61853:EDNRA
gene id: 61853:EDNRA
uniprot id: G1R0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

61853:LOC100584964
gene id: 61853:LOC100584964
uniprot id: G1SC35
names: Subcellular Location Annotation
messages: Membrane

61853:MCHR2
gene id: 61853:MCHR2
uniprot id: G1RUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ARG1
gene id: 61853:ARG1
uniprot id: G1RVZ9
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

61853:LOC100584900
gene id: 61853:LOC100584900
uniprot id: G1SBS1
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

61853:HOXC5
gene id: 61853:HOXC5
uniprot id: G1S7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61853:LOC100597482
gene id: 61853:LOC100597482
uniprot id: G1SCA2
names: Subcellular Location Annotation
messages: Membrane

61853:CMKLR1
gene id: 61853:CMKLR1
uniprot id: G1R4V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

61853:TSHZ1
gene id: 61853:TSHZ1
uniprot id: G1SA11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

61853:MASP1
gene id: 61853:MASP1
uniprot id: A0A2I3GNR6
uniprot id: A0A2I3GQD9
uniprot id: G1R4M8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:STX7
gene id: 61853:STX7
uniprot id: G1RWV0
names: Similarity
messages: Belongs to the syntaxin family.

61853:MRPL53
gene id: 61853:MRPL53
uniprot id: A0A2I3G879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

61853:CREB3L2
gene id: 61853:CREB3L2
uniprot id: G1RTM9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61853:NUP50
gene id: 61853:NUP50
uniprot id: A0A2I3H5A5
names: Subcellular Location Annotation
messages: nuclear pore complex

61853:ALG13
gene id: 61853:ALG13
uniprot id: A0A2I3G9S4
uniprot id: A0A2I3H3T1
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

61853:SH3GL2
gene id: 61853:SH3GL2
uniprot id: A0A2I3HW13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

61853:SLC25A53
gene id: 61853:SLC25A53
uniprot id: G1S9N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:TUT1
gene id: 61853:TUT1
uniprot id: G1QUG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Nucleus speckle
messages: nucleolus

61853:SFXN1
gene id: 61853:SFXN1
uniprot id: G1QIB8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

61853:IRAK4
gene id: 61853:IRAK4
uniprot id: G1S8E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

61853:LOC100595614
gene id: 61853:LOC100595614
uniprot id: G1S9R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:VSNL1
gene id: 61853:VSNL1
uniprot id: G1QLM9
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

61853:C15H11orf88
gene id: 61853:C15H11orf88
uniprot id: G1R6M8
names: Similarity
messages: Belongs to the HOATZ family.

61853:ACO2
gene id: 61853:ACO2
uniprot id: A0A2I3GCH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

61853:CCSER1
gene id: 61853:CCSER1
uniprot id: A0A2I3HDQ8
uniprot id: G1RVX8
names: Similarity
messages: Belongs to the CCSER family.

61853:SLC6A15
gene id: 61853:SLC6A15
uniprot id: G1QZV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

61853:TNFSF13B
gene id: 61853:TNFSF13B
uniprot id: A0A2I3GHB1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61853:PROX1
gene id: 61853:PROX1
uniprot id: G1RWC6
names: Subcellular Location Annotation
messages: Nucleus

61853:SOD2
gene id: 61853:SOD2
uniprot id: G1RJQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

61853:SLC6A6
gene id: 61853:SLC6A6
uniprot id: A0A2I3FZC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.
messages: Cell membrane
messages: Membrane

61853:TAF2
gene id: 61853:TAF2
uniprot id: M3ZBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

61853:GPR50
gene id: 61853:GPR50
uniprot id: G1RTJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:GOSR1
gene id: 61853:GOSR1
uniprot id: G1QU95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

61853:OPRK1
gene id: 61853:OPRK1
uniprot id: A0A2I3H616
uniprot id: A0A2I3HAV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with SLC9A3R1. Interacts with GABARAPL1.
messages: Membrane

61853:FAM8A1
gene id: 61853:FAM8A1
uniprot id: G1QK84
names: Subcellular Location Annotation
messages: Membrane

61853:HOXA11
gene id: 61853:HOXA11
uniprot id: G1RYA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61853:CAPN7
gene id: 61853:CAPN7
uniprot id: G1QME6
names: Similarity
messages: Belongs to the peptidase C2 family.

61853:SPACA5B
gene id: 61853:SPACA5B
uniprot id: G1QTF5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

61853:CUTC
gene id: 61853:CUTC
uniprot id: A0A2I3HPK0
names: Similarity
messages: Belongs to the CutC family.

61853:TRMT11
gene id: 61853:TRMT11
uniprot id: G1RV59
names: Function
names: Subunit
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.
messages: Interacts with TRMT112.

61853:IPO11
gene id: 61853:IPO11
uniprot id: G1QSI3
names: Subcellular Location Annotation
messages: Cytoplasm

61853:TNPO1
gene id: 61853:TNPO1
uniprot id: G1QXD5
names: Subcellular Location Annotation
messages: Cytoplasm

61853:TSNAX
gene id: 61853:TSNAX
uniprot id: A0A2I3GLF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

61853:FABP7
gene id: 61853:FABP7
uniprot id: A0A2I3H4D4
uniprot id: G1RU59
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:LOC100595279
gene id: 61853:LOC100595279
uniprot id: A0A2I3GR51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

61853:LOC100582948
gene id: 61853:LOC100582948
uniprot id: G1R883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

61853:TRDMT1
gene id: 61853:TRDMT1
uniprot id: G1RPT3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

61853:ADORA3
gene id: 61853:ADORA3
uniprot id: A0A2I3G080
uniprot id: A0A2I3GKD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

61853:XKR5
gene id: 61853:XKR5
uniprot id: G1RY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61853:IL13
gene id: 61853:IL13
uniprot id: A0A2I3GGK5
uniprot id: A0A2I3GIU9
names: Subunit
messages: Interacts with IL13RA2.

61853:IYD
gene id: 61853:IYD
uniprot id: A0A2I3GFV1
uniprot id: G1RZH7
uniprot id: G1RZH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane

61853:CPA3
gene id: 61853:CPA3
uniprot id: G1QQ60
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:SFRP1
gene id: 61853:SFRP1
uniprot id: G1RPU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:GJA10
gene id: 61853:GJA10
uniprot id: A0A654ICS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:BAZ2A
gene id: 61853:BAZ2A
uniprot id: A0A2I3G1T6
names: Similarity
messages: Belongs to the WAL family.

61853:CA9
gene id: 61853:CA9
uniprot id: A0A2I3GE59
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61853:RDX
gene id: 61853:RDX
uniprot id: G1R6L7
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61853:SRF
gene id: 61853:SRF
uniprot id: G1QVY4
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100584639
gene id: 61853:LOC100584639
uniprot id: G1RER6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

61853:BGLAP
gene id: 61853:BGLAP
uniprot id: A0A2I3GHP2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

61853:GPR12
gene id: 61853:GPR12
uniprot id: A0A2I3H7W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SFN
gene id: 61853:SFN
uniprot id: G1SAD1
names: Similarity
messages: Belongs to the 14-3-3 family.

61853:ELP3
gene id: 61853:ELP3
uniprot id: G1S3P5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

61853:TPRG1
gene id: 61853:TPRG1
uniprot id: A0A2I3GTK2
names: Similarity
messages: Belongs to the TPRG1 family.

61853:SLC23A3
gene id: 61853:SLC23A3
uniprot id: A0A2I3HYR4
uniprot id: G1RCV5
names: Subcellular Location Annotation
messages: Membrane

61853:GTF2B
gene id: 61853:GTF2B
uniprot id: G1RGV2
names: Similarity
messages: Belongs to the TFIIB family.

61853:KRT71
gene id: 61853:KRT71
uniprot id: G1S7Q3
names: Similarity
messages: Belongs to the intermediate filament family.

61853:BMT2
gene id: 61853:BMT2
uniprot id: G1RKR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

61853:CBX3
gene id: 61853:CBX3
uniprot id: G1RY36
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100602794
gene id: 61853:LOC100602794
uniprot id: A0A2I3FZX1
uniprot id: G1QQ51
names: Similarity
messages: Belongs to the CD36 family.

61853:SSBP2
gene id: 61853:SSBP2
uniprot id: A0A2I3HNI0
uniprot id: G1RRV5
names: Subcellular Location Annotation
messages: Nucleus

61853:ST8SIA2
gene id: 61853:ST8SIA2
uniprot id: A0A2I3GH03
uniprot id: G1RP15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:C8H9orf78
gene id: 61853:C8H9orf78
uniprot id: G1S7D9
names: Similarity
messages: Belongs to the TLS1 family.

61853:GHR
gene id: 61853:GHR
uniprot id: A0A2I3G2M2
uniprot id: A0A2I3HTG2
uniprot id: G1S401
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

61853:CCDC65
gene id: 61853:CCDC65
uniprot id: G1S861
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

61853:CSNK1G3
gene id: 61853:CSNK1G3
uniprot id: G1RN92
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

61853:COPB1
gene id: 61853:COPB1
uniprot id: G1S7J6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

61853:BSX
gene id: 61853:BSX
uniprot id: G1R766
names: Subcellular Location Annotation
messages: Nucleus

61853:RBM15
gene id: 61853:RBM15
uniprot id: G1QTT0
names: Similarity
messages: Belongs to the RRM Spen family.

61853:EPS8
gene id: 61853:EPS8
uniprot id: G1QVP9
names: Similarity
messages: Belongs to the EPS8 family.

61853:RPS24
gene id: 61853:RPS24
uniprot id: A0A2I3HLL8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.
messages: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

61853:SETD6
gene id: 61853:SETD6
uniprot id: A0A2I3GJ66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

61853:SERPINB12
gene id: 61853:SERPINB12
uniprot id: G1RBV1
names: Similarity
messages: Belongs to the serpin family.

61853:ZPBP
gene id: 61853:ZPBP
uniprot id: G1QXC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

61853:TRPC5
gene id: 61853:TRPC5
uniprot id: G1RWZ4
names: Subcellular Location Annotation
messages: Membrane

61853:SIAH2
gene id: 61853:SIAH2
uniprot id: G1QSY7
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

61853:ANXA1
gene id: 61853:ANXA1
uniprot id: G1QL21
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

61853:LOC100581433
gene id: 61853:LOC100581433
uniprot id: G1SBV9
names: Subcellular Location Annotation
messages: Membrane

61853:TUSC3
gene id: 61853:TUSC3
uniprot id: G1QPB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:ADAMTS6
gene id: 61853:ADAMTS6
uniprot id: G1QT93
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:GSC
gene id: 61853:GSC
uniprot id: G1S677
names: Subcellular Location Annotation
messages: Nucleus

61853:STEAP2
gene id: 61853:STEAP2
uniprot id: G1RYQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

61853:LOC100607085
gene id: 61853:LOC100607085
uniprot id: A0A2I3HE97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

61853:PDSS2
gene id: 61853:PDSS2
uniprot id: G1RSV5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61853:TYRP1
gene id: 61853:TYRP1
uniprot id: G1S7E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

61853:CDK4
gene id: 61853:CDK4
uniprot id: G1S5W7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:SLC30A1
gene id: 61853:SLC30A1
uniprot id: G1QQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61853:RPN1
gene id: 61853:RPN1
uniprot id: G1RW20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

61853:PTGES3
gene id: 61853:PTGES3
uniprot id: A0A2I3HU89
uniprot id: G1S6N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

61853:MINAR2
gene id: 61853:MINAR2
uniprot id: G1RPB9
names: Similarity
messages: Belongs to the MINAR family.

61853:PGAM2
gene id: 61853:PGAM2
uniprot id: G1QTL8
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61853:CDC25A
gene id: 61853:CDC25A
uniprot id: G1R3L4
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

61853:NQO2
gene id: 61853:NQO2
uniprot id: A0A2I3FRJ9
uniprot id: G1RJM5
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

61853:PLIN5
gene id: 61853:PLIN5
uniprot id: G1RSA4
names: Similarity
messages: Belongs to the perilipin family.

61853:IGF1
gene id: 61853:IGF1
uniprot id: A0A2I3H886
uniprot id: A0A2I3HN66
uniprot id: G1R3K2
uniprot id: G1R3K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

61853:IDO1
gene id: 61853:IDO1
uniprot id: G1RPR1
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

61853:NUS1
gene id: 61853:NUS1
uniprot id: A0A2I3GTR9
names: Similarity
messages: Belongs to the UPP synthase family.

61853:LGSN
gene id: 61853:LGSN
uniprot id: A0A2I3G9V3
uniprot id: A0A2I3HGC7
names: Similarity
messages: Belongs to the glutamine synthetase family.

61853:FOS
gene id: 61853:FOS
uniprot id: A0A2I3HV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

61853:EMG1
gene id: 61853:EMG1
uniprot id: G1QYY8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

61853:STK4
gene id: 61853:STK4
uniprot id: A0A2I3GAZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

61853:HFE
gene id: 61853:HFE
uniprot id: A0A2I3FYK5
uniprot id: A0A2I3G7K2
uniprot id: A0A2I3HV94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MHC class I family.
messages: Binds TFR through the extracellular domain in a pH-dependent manner.
messages: Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
messages: Cell membrane

61853:CCNF
gene id: 61853:CCNF
uniprot id: G1RDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: centriole
messages: perinuclear region

61853:RDH16
gene id: 61853:RDH16
uniprot id: G1S6M0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:LOC100583707
gene id: 61853:LOC100583707
uniprot id: G1QJJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCO1/2 family.
messages: Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.
messages: Homodimer.
messages: Mitochondrion inner membrane

61853:CSTF1
gene id: 61853:CSTF1
uniprot id: G1R5V2
names: Subcellular Location Annotation
messages: Nucleus

61853:PI4K2B
gene id: 61853:PI4K2B
uniprot id: G1S4I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

61853:MEIS1
gene id: 61853:MEIS1
uniprot id: G1RFZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

61853:CEP57
gene id: 61853:CEP57
uniprot id: G1R671
names: Similarity
messages: Belongs to the translokin family.

61853:SLC39A14
gene id: 61853:SLC39A14
uniprot id: A0A2I3GVX1
names: Subcellular Location Annotation
messages: Membrane

61853:AKR1B10
gene id: 61853:AKR1B10
uniprot id: G1RRL9
names: Similarity
messages: Belongs to the aldo/keto reductase family.

61853:LOC100579964
gene id: 61853:LOC100579964
uniprot id: G1QKD3
names: Similarity
messages: Belongs to the KHDC1 family.

61853:SNRPF
gene id: 61853:SNRPF
uniprot id: G1R1J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

61853:PRKAB2
gene id: 61853:PRKAB2
uniprot id: G1QH07
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

61853:TMED3
gene id: 61853:TMED3
uniprot id: A0A2I3GZ70
uniprot id: G1RC42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61853:NPR3
gene id: 61853:NPR3
uniprot id: G1RVE3
names: Subcellular Location Annotation
messages: Membrane

61853:CDK5RAP1
gene id: 61853:CDK5RAP1
uniprot id: A0A2I3HGD5
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

61853:GABRB2
gene id: 61853:GABRB2
uniprot id: A0A2I4HY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:UFL1
gene id: 61853:UFL1
uniprot id: A0A2I3HDZ2
names: Similarity
messages: Belongs to the UFL1 family.

61853:STMN3
gene id: 61853:STMN3
uniprot id: G1RGG5
names: Function
names: Similarity
messages: Belongs to the stathmin family.
messages: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

61853:FAP
gene id: 61853:FAP
uniprot id: A0A2I3GN71
uniprot id: G1QQS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

61853:PLA2G2A
gene id: 61853:PLA2G2A
uniprot id: G1R8T6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61853:ND6
gene id: 61853:ND6
uniprot id: D4QAU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61853:CDH24
gene id: 61853:CDH24
uniprot id: G1RY18
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:TASP1
gene id: 61853:TASP1
uniprot id: G1RWS8
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

61853:HLF
gene id: 61853:HLF
uniprot id: G1R959
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

61853:SEC31A
gene id: 61853:SEC31A
uniprot id: A0A2I3HES2
uniprot id: A0A2I3HR75
uniprot id: A0A2I3I053
uniprot id: G1RCD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: Endoplasmic reticulum membrane

61853:HTR2A
gene id: 61853:HTR2A
uniprot id: A0A2I3H7S9
uniprot id: G1QRK0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

61853:CPQ
gene id: 61853:CPQ
uniprot id: G1QU32
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. The monomeric form is inactive while the homodimer is active.
messages: Lysosome
messages: Secreted

61853:KCNMA1
gene id: 61853:KCNMA1
uniprot id: G1S4S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
messages: Membrane

61853:RING1
gene id: 61853:RING1
uniprot id: G1R541
names: Function
names: Subcellular Location Annotation
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

61853:AGTRAP
gene id: 61853:AGTRAP
uniprot id: G1REV9
names: Subcellular Location Annotation
messages: Membrane

61853:MEP1A
gene id: 61853:MEP1A
uniprot id: G1QWR5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SLC17A2
gene id: 61853:SLC17A2
uniprot id: A0A2I3HTT9
uniprot id: G1QRV0
names: Subcellular Location Annotation
messages: Membrane

61853:KCNG4
gene id: 61853:KCNG4
uniprot id: G1RJQ8
names: Subcellular Location Annotation
messages: Membrane

61853:PADI4
gene id: 61853:PADI4
uniprot id: G1R8C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

61853:PGPEP1
gene id: 61853:PGPEP1
uniprot id: A0A2I3HNV5
uniprot id: G1R258
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

61853:DBX2
gene id: 61853:DBX2
uniprot id: G1S8D6
names: Subcellular Location Annotation
messages: Nucleus

61853:DUSP4
gene id: 61853:DUSP4
uniprot id: G1S474
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

61853:SCGB2A2
gene id: 61853:SCGB2A2
uniprot id: A0A2I3H3X3
uniprot id: G1QTE4
names: Subcellular Location Annotation
messages: Secreted

61853:DSG4
gene id: 61853:DSG4
uniprot id: A0A2I3H3N0
uniprot id: G1R3Y0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61853:ETFDH
gene id: 61853:ETFDH
uniprot id: G1R3L3
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

61853:LOC100579584
gene id: 61853:LOC100579584
uniprot id: G1R127
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:RAD51
gene id: 61853:RAD51
uniprot id: A0A2I3H1V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

61853:MOB1B
gene id: 61853:MOB1B
uniprot id: A0A2I3H2X7
names: Similarity
messages: Belongs to the MOB1/phocein family.

61853:KRT6A
gene id: 61853:KRT6A
uniprot id: A0A2I3GD99
names: Similarity
messages: Belongs to the intermediate filament family.

61853:GNG3
gene id: 61853:GNG3
uniprot id: G1QVF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61853:STX2
gene id: 61853:STX2
uniprot id: A0A2I3GGA6
uniprot id: G1RA20
names: Similarity
messages: Belongs to the syntaxin family.

61853:PSMA5
gene id: 61853:PSMA5
uniprot id: A0A2I3GAD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61853:SMAD2
gene id: 61853:SMAD2
uniprot id: G1RL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

61853:NAGPA
gene id: 61853:NAGPA
uniprot id: G1RG36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:GNL2
gene id: 61853:GNL2
uniprot id: G1RLM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

61853:COMTD1
gene id: 61853:COMTD1
uniprot id: G1S4R3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

61853:IL17C
gene id: 61853:IL17C
uniprot id: G1QIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61853:SF3B6
gene id: 61853:SF3B6
uniprot id: G1QJ63
names: Subcellular Location Annotation
messages: Nucleus

61853:EHF
gene id: 61853:EHF
uniprot id: A0A2I3GRJ0
uniprot id: A0A2I3HJ83
uniprot id: G1S8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:SLCO1A2
gene id: 61853:SLCO1A2
uniprot id: G1QXW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

61853:ZPR1
gene id: 61853:ZPR1
uniprot id: G1R6X0
names: Similarity
messages: Belongs to the ZPR1 family.

61853:NOX4
gene id: 61853:NOX4
uniprot id: A0A2I3HSI0
uniprot id: G1S1V1
names: Subcellular Location Annotation
messages: Membrane

61853:TUT7
gene id: 61853:TUT7
uniprot id: G1QZG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

61853:IZUMO3
gene id: 61853:IZUMO3
uniprot id: A0A2I3GBT4
names: Similarity
messages: Belongs to the Izumo family.

61853:EDNRB
gene id: 61853:EDNRB
uniprot id: G1S310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ADAMTS1
gene id: 61853:ADAMTS1
uniprot id: G1QR38
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:TPM3
gene id: 61853:TPM3
uniprot id: A0A2I3FRR0
uniprot id: A0A2I3G1Q7
uniprot id: A0A2I3GH21
uniprot id: A0A2I3GVM9
uniprot id: A0A2I3H3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61853:TNKS2
gene id: 61853:TNKS2
uniprot id: M3ZAS3
names: Similarity
messages: Belongs to the ARTD/PARP family.

61853:BMP15
gene id: 61853:BMP15
uniprot id: G1R9Q9
names: Similarity
messages: Belongs to the TGF-beta family.

61853:SRRD
gene id: 61853:SRRD
uniprot id: G1R870
names: Similarity
messages: Belongs to the SRR1 family.

61853:CA7
gene id: 61853:CA7
uniprot id: A0A2I3HBU9
uniprot id: A0A2I3HLD6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61853:SLC10A3
gene id: 61853:SLC10A3
uniprot id: G1RVS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61853:LOC100604305
gene id: 61853:LOC100604305
uniprot id: G1QYQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

61853:GTF2H1
gene id: 61853:GTF2H1
uniprot id: G1S7T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

61853:FAM110D
gene id: 61853:FAM110D
uniprot id: G1SAD0
names: Similarity
messages: Belongs to the FAM110 family.

61853:LOC100582721
gene id: 61853:LOC100582721
uniprot id: G1QWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

61853:CHAC1
gene id: 61853:CHAC1
uniprot id: G1QTA1
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

61853:SMN1
gene id: 61853:SMN1
uniprot id: A0A2I3HCL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

61853:GNAL
gene id: 61853:GNAL
uniprot id: A0A2I3HJU5
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

61853:SPRY1
gene id: 61853:SPRY1
uniprot id: A0A2I3G3Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sprouty family.
messages: Cytoplasm
messages: Membrane

61853:SDHAF4
gene id: 61853:SDHAF4
uniprot id: A0A2I3HE54
names: Similarity
messages: Belongs to the SDHAF4 family.

61853:PDIK1L
gene id: 61853:PDIK1L
uniprot id: G1RD92
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:LOC100579841
gene id: 61853:LOC100579841
uniprot id: G1QZQ2
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

61853:ND3
gene id: 61853:ND3
uniprot id: E7EAE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

61853:TMOD1
gene id: 61853:TMOD1
uniprot id: G1S4T8
names: Subcellular Location Annotation
messages: cytoskeleton

61853:VNN3
gene id: 61853:VNN3
uniprot id: A0A2I3HJ48
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

61853:FAM91A1
gene id: 61853:FAM91A1
uniprot id: G1R034
names: Similarity
messages: Belongs to the FAM91 family.

61853:NSDHL
gene id: 61853:NSDHL
uniprot id: G1RUE7
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61853:C5
gene id: 61853:C5
uniprot id: G1S5G0
names: Subcellular Location Annotation
messages: Secreted

61853:CDC45
gene id: 61853:CDC45
uniprot id: A0A2I3GXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

61853:ZNF18
gene id: 61853:ZNF18
uniprot id: G1RWP5
names: Subcellular Location Annotation
messages: Nucleus

61853:C4BPB
gene id: 61853:C4BPB
uniprot id: H9H9Y9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SERPING1
gene id: 61853:SERPING1
uniprot id: G1RQM7
names: Similarity
messages: Belongs to the serpin family.

61853:MRFAP1L1
gene id: 61853:MRFAP1L1
uniprot id: G1RM76
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

61853:EXOSC9
gene id: 61853:EXOSC9
uniprot id: A0A2I3GCY8
names: Subcellular Location Annotation
messages: Cytoplasm

61853:POT1
gene id: 61853:POT1
uniprot id: A0A2I3GN50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

61853:WDR48
gene id: 61853:WDR48
uniprot id: G1R0H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

61853:ZFYVE27
gene id: 61853:ZFYVE27
uniprot id: A0A2I3G838
uniprot id: G1RVW7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

61853:PGM2
gene id: 61853:PGM2
uniprot id: G1S585
names: Similarity
messages: Belongs to the phosphohexose mutase family.

61853:HOXC4
gene id: 61853:HOXC4
uniprot id: G1S7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61853:FMO1
gene id: 61853:FMO1
uniprot id: A0A2I3HBN2
uniprot id: G1RYT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

61853:RPRM
gene id: 61853:RPRM
uniprot id: G1SBZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reprimo family.
messages: Cytoplasm
messages: Membrane

61853:ASPH
gene id: 61853:ASPH
uniprot id: A0A2I3GZ41
uniprot id: A0A2I3HSK8
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61853:OLFM1
gene id: 61853:OLFM1
uniprot id: G1RBX1
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61853:CTH
gene id: 61853:CTH
uniprot id: G1RE31
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

61853:TMEM231
gene id: 61853:TMEM231
uniprot id: G1RRG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

61853:HOXC8
gene id: 61853:HOXC8
uniprot id: G1S7G2
names: Subcellular Location Annotation
messages: Nucleus

61853:SULT2B1
gene id: 61853:SULT2B1
uniprot id: G1QX14
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:ATIC
gene id: 61853:ATIC
uniprot id: G1R6I6
names: Similarity
messages: Belongs to the PurH family.

61853:CUL4A
gene id: 61853:CUL4A
uniprot id: G1QIW7
names: Similarity
messages: Belongs to the cullin family.

61853:CLNS1A
gene id: 61853:CLNS1A
uniprot id: G1S432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pICln (TC 1.A.47) family.
messages: Nucleus

61853:SFXN2
gene id: 61853:SFXN2
uniprot id: A0A2I3HF35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

61853:SMUG1
gene id: 61853:SMUG1
uniprot id: G1S7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

61853:ATG5
gene id: 61853:ATG5
uniprot id: A0A2I3GG35
uniprot id: G1RSA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

61853:CCDC47
gene id: 61853:CCDC47
uniprot id: G1QWF4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Rough endoplasmic reticulum membrane

61853:FCF1
gene id: 61853:FCF1
uniprot id: G1S2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

61853:WDFY1
gene id: 61853:WDFY1
uniprot id: G1RF30
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61853:FAM133B
gene id: 61853:FAM133B
uniprot id: G1RZD1
names: Similarity
messages: Belongs to the FAM133 family.

61853:TENT5C
gene id: 61853:TENT5C
uniprot id: A0A2I3H148
names: Similarity
messages: Belongs to the TENT family.

61853:LOC100603023
gene id: 61853:LOC100603023
uniprot id: A0A2I3HCW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

61853:ELAC1
gene id: 61853:ELAC1
uniprot id: G1RME1
names: Subunit
messages: Homodimer.

61853:TAF13
gene id: 61853:TAF13
uniprot id: G1QPF7
names: Subcellular Location Annotation
messages: Nucleus

61853:TET1
gene id: 61853:TET1
uniprot id: G1RM77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Chromosome
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

61853:MOB1A
gene id: 61853:MOB1A
uniprot id: G1QHK0
names: Similarity
messages: Belongs to the MOB1/phocein family.

61853:SLC33A1
gene id: 61853:SLC33A1
uniprot id: A0A2I3HN55
names: Subcellular Location Annotation
messages: Membrane

61853:ESD
gene id: 61853:ESD
uniprot id: G1QRI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

61853:UBE2A
gene id: 61853:UBE2A
uniprot id: H9H9Y4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:LOC100587002
gene id: 61853:LOC100587002
uniprot id: G1RB34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

61853:XIAP
gene id: 61853:XIAP
uniprot id: G1RYI2
names: Similarity
messages: Belongs to the IAP family.

61853:TMEM208
gene id: 61853:TMEM208
uniprot id: A0A2I3GWJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

61853:MEP1B
gene id: 61853:MEP1B
uniprot id: G1R3K9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SLC5A10
gene id: 61853:SLC5A10
uniprot id: A0A2I3GYA4
uniprot id: G1RS13
uniprot id: G1RS29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61853:TMPRSS11F
gene id: 61853:TMPRSS11F
uniprot id: G1RD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61853:DYNC2LI1
gene id: 61853:DYNC2LI1
uniprot id: G1S499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

61853:ADAMTS5
gene id: 61853:ADAMTS5
uniprot id: G1QR75
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:STX4
gene id: 61853:STX4
uniprot id: G1S1Y7
names: Similarity
messages: Belongs to the syntaxin family.

61853:IFNAR1
gene id: 61853:IFNAR1
uniprot id: A0A2I3HAU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

61853:COL4A6
gene id: 61853:COL4A6
uniprot id: A0A2I3G8L8
uniprot id: A0A2I3HT29
uniprot id: G1RVH3
uniprot id: M3ZCH1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61853:RBM3
gene id: 61853:RBM3
uniprot id: A0A2I3GZU2
names: Subcellular Location Annotation
messages: Cytoplasm

61853:PRPS1
gene id: 61853:PRPS1
uniprot id: A0A2I3FSD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

61853:BEST4
gene id: 61853:BEST4
uniprot id: G1RVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

61853:SMPDL3A
gene id: 61853:SMPDL3A
uniprot id: G1RU96
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

61853:VPS52
gene id: 61853:VPS52
uniprot id: G1R551
names: Similarity
messages: Belongs to the VPS52 family.

61853:IRF4
gene id: 61853:IRF4
uniprot id: G1RI69
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:APOB
gene id: 61853:APOB
uniprot id: G1QIQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CRH
gene id: 61853:CRH
uniprot id: A0A2I3GJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

61853:MSRB2
gene id: 61853:MSRB2
uniprot id: G1RQY7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

61853:BMP3
gene id: 61853:BMP3
uniprot id: G1RAW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

61853:DDX55
gene id: 61853:DDX55
uniprot id: A0A2I3GTY0
names: Similarity
messages: Belongs to the DEAD box helicase family.

61853:PRKCQ
gene id: 61853:PRKCQ
uniprot id: G1RM82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

61853:SLC16A14
gene id: 61853:SLC16A14
uniprot id: G1RTQ8
names: Subcellular Location Annotation
messages: Membrane

61853:MRPS11
gene id: 61853:MRPS11
uniprot id: A0A2I3G2D3
uniprot id: A0A2I3HJZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

61853:SLC28A2
gene id: 61853:SLC28A2
uniprot id: G1R1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

61853:TINAG
gene id: 61853:TINAG
uniprot id: G1QT07
names: Similarity
messages: Belongs to the peptidase C1 family.

61853:POLR3GL
gene id: 61853:POLR3GL
uniprot id: G1R1F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61853:THOC7
gene id: 61853:THOC7
uniprot id: G1RM39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

61853:GPR171
gene id: 61853:GPR171
uniprot id: G1SBA1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:GALNT6
gene id: 61853:GALNT6
uniprot id: M3ZBY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:NOP10
gene id: 61853:NOP10
uniprot id: G1RJU0
names: Similarity
messages: Belongs to the NOP10 family.

61853:NUDT21
gene id: 61853:NUDT21
uniprot id: G1QN95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

61853:CLDN10
gene id: 61853:CLDN10
uniprot id: A0A2I3H220
uniprot id: G1S3S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:STARD5
gene id: 61853:STARD5
uniprot id: G1QL54
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

61853:LOC100597818
gene id: 61853:LOC100597818
uniprot id: G1SCA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:LOC100596515
gene id: 61853:LOC100596515
uniprot id: G1SBN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:TP53RK
gene id: 61853:TP53RK
uniprot id: A0A2I3HVJ4
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

61853:LHX8
gene id: 61853:LHX8
uniprot id: G1REJ8
names: Subcellular Location Annotation
messages: Nucleus

61853:TXNRD2
gene id: 61853:TXNRD2
uniprot id: G1R0R1
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

61853:TOR1AIP1
gene id: 61853:TOR1AIP1
uniprot id: G1S125
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

61853:LOC100601030
gene id: 61853:LOC100601030
uniprot id: G1RTC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61853:GALT
gene id: 61853:GALT
uniprot id: A0A2I3GC08
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

61853:CAPG
gene id: 61853:CAPG
uniprot id: G1QMD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
messages: Cytoplasm
messages: Melanosome
messages: Nucleus
messages: lamellipodium
messages: ruffle

61853:SEMA7A
gene id: 61853:SEMA7A
uniprot id: G1RWI4
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PTCD2
gene id: 61853:PTCD2
uniprot id: G1QX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

61853:ISM1
gene id: 61853:ISM1
uniprot id: G1RWP6
names: Similarity
messages: Belongs to the isthmin family.

61853:CTSS
gene id: 61853:CTSS
uniprot id: G1RFY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61853:ASB15
gene id: 61853:ASB15
uniprot id: G1RND2
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:KCNAB1
gene id: 61853:KCNAB1
uniprot id: A0A2I3G3J1
uniprot id: A0A2I3GYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61853:NSUN4
gene id: 61853:NSUN4
uniprot id: G1S3E8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61853:LOC100579598
gene id: 61853:LOC100579598
uniprot id: A0A2I3HNK5
names: Subcellular Location Annotation
messages: Membrane

61853:SUV39H1
gene id: 61853:SUV39H1
uniprot id: G1R8Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

61853:COLGALT2
gene id: 61853:COLGALT2
uniprot id: G1S8Q8
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

61853:PTGER4
gene id: 61853:PTGER4
uniprot id: G1S375
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

61853:DMAP1
gene id: 61853:DMAP1
uniprot id: A0A2I3GJZ0
names: Subcellular Location Annotation
messages: Nucleus

61853:PSMB4
gene id: 61853:PSMB4
uniprot id: G1RGU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

61853:DAZAP2
gene id: 61853:DAZAP2
uniprot id: A0A2I3G342
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

61853:HINT1
gene id: 61853:HINT1
uniprot id: A0A2I3G9Q4
names: Similarity
messages: Belongs to the HINT family.

61853:SERPINB13
gene id: 61853:SERPINB13
uniprot id: A0A2I3HHW0
names: Similarity
messages: Belongs to the serpin family.

61853:POP7
gene id: 61853:POP7
uniprot id: G1RMN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

61853:ENO4
gene id: 61853:ENO4
uniprot id: G1S3E2
names: Similarity
messages: Belongs to the enolase family.

61853:POLR2F
gene id: 61853:POLR2F
uniprot id: G1RY98
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

61853:BAMBI
gene id: 61853:BAMBI
uniprot id: G1S5A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

61853:CCNL1
gene id: 61853:CCNL1
uniprot id: A0A2I3HHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin L subfamily.
messages: Nucleus speckle
messages: nucleoplasm

61853:DNASE1L1
gene id: 61853:DNASE1L1
uniprot id: G1RVD0
names: Similarity
messages: Belongs to the DNase I family.

61853:AKAP8
gene id: 61853:AKAP8
uniprot id: G1QZJ1
names: Similarity
messages: Belongs to the AKAP95 family.

61853:RAD9B
gene id: 61853:RAD9B
uniprot id: A0A2I3HIP9
uniprot id: G1QRV7
names: Similarity
messages: Belongs to the rad9 family.

61853:CLCA1
gene id: 61853:CLCA1
uniprot id: G1RGM8
names: Similarity
messages: Belongs to the CLCR family.

61853:CALHM4
gene id: 61853:CALHM4
uniprot id: A0A2I3HUP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61853:SAA2
gene id: 61853:SAA2
uniprot id: G1S7R0
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

61853:S100A5
gene id: 61853:S100A5
uniprot id: G1RHF8
names: Similarity
messages: Belongs to the S-100 family.

61853:TP53INP2
gene id: 61853:TP53INP2
uniprot id: G1RGG7
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

61853:EXOSC2
gene id: 61853:EXOSC2
uniprot id: G1RPS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

61853:LOC100579776
gene id: 61853:LOC100579776
uniprot id: G1SCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PSMG2
gene id: 61853:PSMG2
uniprot id: G1RCU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

61853:UBAC1
gene id: 61853:UBAC1
uniprot id: G1RCE4
names: Subcellular Location Annotation
messages: Cytoplasm

61853:LOC100581795
gene id: 61853:LOC100581795
uniprot id: A0A2I3H1D0
names: Similarity
messages: Belongs to the ficolin lectin family.

61853:BRINP2
gene id: 61853:BRINP2
uniprot id: G1RZY2
names: Similarity
messages: Belongs to the BRINP family.

61853:THYN1
gene id: 61853:THYN1
uniprot id: G1RPM0
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

61853:AKR1D1
gene id: 61853:AKR1D1
uniprot id: A0A2I3H2T0
uniprot id: A0A2I3HY67
uniprot id: G1RTU2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

61853:SCGB2A1
gene id: 61853:SCGB2A1
uniprot id: G1QTD2
names: Subcellular Location Annotation
messages: Secreted

61853:LOC100587360
gene id: 61853:LOC100587360
uniprot id: G1RMP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

61853:CDC42SE1
gene id: 61853:CDC42SE1
uniprot id: A0A2I3H9L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

61853:SORCS3
gene id: 61853:SORCS3
uniprot id: G1RZJ4
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

61853:ST3GAL4
gene id: 61853:ST3GAL4
uniprot id: G1R7C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:SENP8
gene id: 61853:SENP8
uniprot id: A0A2I3G8U3
names: Similarity
messages: Belongs to the peptidase C48 family.

61853:ZMPSTE24
gene id: 61853:ZMPSTE24
uniprot id: A0A2I3I081
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

61853:TAF9B
gene id: 61853:TAF9B
uniprot id: G1QL43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

61853:TRAPPC13
gene id: 61853:TRAPPC13
uniprot id: G1QTS9
uniprot id: M3ZA02
names: Similarity
names: Subunit
messages: Belongs to the TRAPPC13 family.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.

61853:SLC46A3
gene id: 61853:SLC46A3
uniprot id: G1QIG6
names: Subcellular Location Annotation
messages: Membrane

61853:AQP4
gene id: 61853:AQP4
uniprot id: G1R432
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61853:RPL23
gene id: 61853:RPL23
uniprot id: A0A2I3G6A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61853:CPA6
gene id: 61853:CPA6
uniprot id: G1RJR3
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:C12H1orf52
gene id: 61853:C12H1orf52
uniprot id: G1RG63
names: Similarity
messages: Belongs to the UPF0690 family.

61853:LOC100597116
gene id: 61853:LOC100597116
uniprot id: A0A2I3HEN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

61853:POU4F3
gene id: 61853:POU4F3
uniprot id: G1RFQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

61853:IDO2
gene id: 61853:IDO2
uniprot id: G1RPS9
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

61853:LOXL3
gene id: 61853:LOXL3
uniprot id: A0A2I3FYI9
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

61853:CD163
gene id: 61853:CD163
uniprot id: G1QZT7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:IFNA8
gene id: 61853:IFNA8
uniprot id: A0A2I3GCS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:RUVBL1
gene id: 61853:RUVBL1
uniprot id: G1RVN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

61853:CHRM2
gene id: 61853:CHRM2
uniprot id: A0A2I3GG77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

61853:ELOVL5
gene id: 61853:ELOVL5
uniprot id: G1QTK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

61853:RPS13
gene id: 61853:RPS13
uniprot id: A0A2I3FWD3
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

61853:UGT8
gene id: 61853:UGT8
uniprot id: G1S2B0
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

61853:TMEM159
gene id: 61853:TMEM159
uniprot id: G1RNT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

61853:PSMA2
gene id: 61853:PSMA2
uniprot id: G1QSE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61853:ERAP1
gene id: 61853:ERAP1
uniprot id: G1RV93
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61853:CFLAR
gene id: 61853:CFLAR
uniprot id: G1R5J7
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:CNOT10
gene id: 61853:CNOT10
uniprot id: G1QWN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

61853:GAL3ST1
gene id: 61853:GAL3ST1
uniprot id: G1QUU5
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

61853:CASP3
gene id: 61853:CASP3
uniprot id: G1RJ33
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:TBX18
gene id: 61853:TBX18
uniprot id: G1RQM8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:RPLP0
gene id: 61853:RPLP0
uniprot id: G1QHI2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

61853:PCYOX1
gene id: 61853:PCYOX1
uniprot id: A0A2I3GZ46
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

61853:STT3A
gene id: 61853:STT3A
uniprot id: G1R799
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

61853:RPL29
gene id: 61853:RPL29
uniprot id: A0A2I3G942
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61853:LRRC51
gene id: 61853:LRRC51
uniprot id: A0A2I3GEM2
uniprot id: A0A2I3HLE0
names: Subcellular Location Annotation
messages: Cytoplasm

61853:BLMH
gene id: 61853:BLMH
uniprot id: A0A2I3H9L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

61853:BHMT2
gene id: 61853:BHMT2
uniprot id: A0A2I3G1M5
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

61853:KCNC4
gene id: 61853:KCNC4
uniprot id: A0A2I3HBF6
uniprot id: G1QTR9
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100597841
gene id: 61853:LOC100597841
uniprot id: G1RNM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

61853:ADGRA3
gene id: 61853:ADGRA3
uniprot id: G1S489
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

61853:CNTFR
gene id: 61853:CNTFR
uniprot id: G1QYB4
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

61853:RAD54L2
gene id: 61853:RAD54L2
uniprot id: G1R5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

61853:MLNR
gene id: 61853:MLNR
uniprot id: G1QTN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:EIF3D
gene id: 61853:EIF3D
uniprot id: G1RX45
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Cytoplasm
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

61853:CDC14A
gene id: 61853:CDC14A
uniprot id: G1RMG1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

61853:PTP4A1
gene id: 61853:PTP4A1
uniprot id: A0A2I3GRY3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61853:KCNJ12
gene id: 61853:KCNJ12
uniprot id: G1RSV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

61853:ZNF280B
gene id: 61853:ZNF280B
uniprot id: G1SBM6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

61853:TFEB
gene id: 61853:TFEB
uniprot id: G1QYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61853:EIF4A2
gene id: 61853:EIF4A2
uniprot id: G1R4H7
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

61853:FUT7
gene id: 61853:FUT7
uniprot id: G1RC41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

61853:CCN4
gene id: 61853:CCN4
uniprot id: A0A2I3H175
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:PLLP
gene id: 61853:PLLP
uniprot id: A0A2I3HND8
names: Subcellular Location Annotation
messages: Membrane

61853:SLC7A6OS
gene id: 61853:SLC7A6OS
uniprot id: G1QZF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

61853:UGP2
gene id: 61853:UGP2
uniprot id: A0A2I3GFJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

61853:PFKFB1
gene id: 61853:PFKFB1
uniprot id: A0A2I3H9T5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

61853:ME3
gene id: 61853:ME3
uniprot id: G1S289
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

61853:MTMR11
gene id: 61853:MTMR11
uniprot id: G1RF23
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61853:LOC100602515
gene id: 61853:LOC100602515
uniprot id: A0A2I3GME3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

61853:WNT3
gene id: 61853:WNT3
uniprot id: G1QYC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:PELI1
gene id: 61853:PELI1
uniprot id: G1RFP9
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

61853:LOC100596554
gene id: 61853:LOC100596554
uniprot id: G1SAW5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:RNF10
gene id: 61853:RNF10
uniprot id: G1S111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

61853:ACSL5
gene id: 61853:ACSL5
uniprot id: G1S106
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

61853:MCM4
gene id: 61853:MCM4
uniprot id: G1RSG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

61853:TNP1
gene id: 61853:TNP1
uniprot id: G1R6Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Nucleus

61853:MET
gene id: 61853:MET
uniprot id: G1RLI8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:LOC100605650
gene id: 61853:LOC100605650
uniprot id: G1QP67
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:NRF1
gene id: 61853:NRF1
uniprot id: A0A2I3HZY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

61853:LPAR6
gene id: 61853:LPAR6
uniprot id: A0A2I3FQI3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:CNRIP1
gene id: 61853:CNRIP1
uniprot id: A0A2I3HH58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

61853:CETN2
gene id: 61853:CETN2
uniprot id: A0A2I3GMP3
names: Similarity
messages: Belongs to the centrin family.

61853:TSFM
gene id: 61853:TSFM
uniprot id: A0A2I3G7P7
uniprot id: A0A2I3GZ06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

61853:IL2
gene id: 61853:IL2
uniprot id: G1RE34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-2 family.
messages: Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
messages: Secreted

61853:GJB6
gene id: 61853:GJB6
uniprot id: A0A2I3H161
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:CERS3
gene id: 61853:CERS3
uniprot id: G1QJT3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61853:S100A11
gene id: 61853:S100A11
uniprot id: G1RH69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

61853:NDUFS3
gene id: 61853:NDUFS3
uniprot id: A0A2I3HIR7
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

61853:LOC100580870
gene id: 61853:LOC100580870
uniprot id: A0A2I3H6Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:DCTN1
gene id: 61853:DCTN1
uniprot id: A0A2I3GPD8
uniprot id: A0A2I3HN47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

61853:LBX1
gene id: 61853:LBX1
uniprot id: G1RXS0
names: Subcellular Location Annotation
messages: Nucleus

61853:RGS7BP
gene id: 61853:RGS7BP
uniprot id: G1QSM7
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

61853:MRPL30
gene id: 61853:MRPL30
uniprot id: A0A2I3HG29
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

61853:ARHGEF12
gene id: 61853:ARHGEF12
uniprot id: A0A2I3HFE2
uniprot id: A0A2I3HG46
uniprot id: G1R756
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane

61853:LOC100581313
gene id: 61853:LOC100581313
uniprot id: G1SCB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:INHBA
gene id: 61853:INHBA
uniprot id: G1QS95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

61853:LTBP1
gene id: 61853:LTBP1
uniprot id: A0A2I3GYJ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:MELK
gene id: 61853:MELK
uniprot id: A0A2I3HA62
uniprot id: A0A2I3HHF6
uniprot id: A0A2I3HP02
uniprot id: A0A2I3HR93
uniprot id: A0A2I3HZD6
uniprot id: G1QUG2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

61853:CAPN10
gene id: 61853:CAPN10
uniprot id: A0A2I3H7S0
names: Similarity
messages: Belongs to the peptidase C2 family.

61853:LOC100604478
gene id: 61853:LOC100604478
uniprot id: A0A2I3HGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

61853:TEC
gene id: 61853:TEC
uniprot id: G1S6G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

61853:LOC100599929
gene id: 61853:LOC100599929
uniprot id: A0A2I3GU47
uniprot id: G1R7W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

61853:SLC16A7
gene id: 61853:SLC16A7
uniprot id: G1S5M0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

61853:TNFAIP1
gene id: 61853:TNFAIP1
uniprot id: G1QN25
names: Similarity
messages: Belongs to the BACURD family.

61853:P3H3
gene id: 61853:P3H3
uniprot id: G1QXR1
names: Similarity
messages: Belongs to the leprecan family.

61853:DTX3
gene id: 61853:DTX3
uniprot id: G1S638
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61853:LOC100607246
gene id: 61853:LOC100607246
uniprot id: G1RYN2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:TIMP2
gene id: 61853:TIMP2
uniprot id: G1QGX5
names: Similarity
names: Subunit
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

61853:C2H16orf70
gene id: 61853:C2H16orf70
uniprot id: G1QWA0
names: Similarity
messages: Belongs to the PHAF1 family.

61853:GCHFR
gene id: 61853:GCHFR
uniprot id: H9HA00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

61853:MCM8
gene id: 61853:MCM8
uniprot id: A0A2I3G2S4
uniprot id: A0A2I3GDI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

61853:PLCB4
gene id: 61853:PLCB4
uniprot id: A0A2I3GKX5
uniprot id: G1RW33
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

61853:PRKAA2
gene id: 61853:PRKAA2
uniprot id: G1RX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: Cytoplasm

61853:NAIF1
gene id: 61853:NAIF1
uniprot id: G1S6X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

61853:LOC100595867
gene id: 61853:LOC100595867
uniprot id: G1S9J2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:UBE2D3
gene id: 61853:UBE2D3
uniprot id: A0A2I3HVI4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:MPZ
gene id: 61853:MPZ
uniprot id: G1RW13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the myelin P0 protein family.
messages: Cell membrane
messages: Homodimer and homotetramer.
messages: Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.
messages: Membrane

61853:CYSTM1
gene id: 61853:CYSTM1
uniprot id: G1RDC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

61853:KIF20A
gene id: 61853:KIF20A
uniprot id: A0A2I3HLT5
uniprot id: G1RBX2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:SMS
gene id: 61853:SMS
uniprot id: G1RG03
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

61853:SSX2IP
gene id: 61853:SSX2IP
uniprot id: M3Z9S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

61853:LOC105739943
gene id: 61853:LOC105739943
uniprot id: G1SB56
names: Subcellular Location Annotation
messages: Nucleus

61853:BATF
gene id: 61853:BATF
uniprot id: G1S3B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

61853:SLC2A13
gene id: 61853:SLC2A13
uniprot id: G1S8H8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61853:LYPD6B
gene id: 61853:LYPD6B
uniprot id: A0A2I3GD49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:CFAP53
gene id: 61853:CFAP53
uniprot id: G1RLR7
names: Similarity
messages: Belongs to the CFAP53 family.

61853:ST14
gene id: 61853:ST14
uniprot id: G1R7E4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S1 family.
messages: Degrades extracellular matrix.
messages: Interacts with CDCP1. May interact with TMEFF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SGTA
gene id: 61853:SGTA
uniprot id: G1QPR8
names: Similarity
messages: Belongs to the SGT family.

61853:KRTCAP2
gene id: 61853:KRTCAP2
uniprot id: G1RMG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

61853:MFAP3
gene id: 61853:MFAP3
uniprot id: G1S3J9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:HACL1
gene id: 61853:HACL1
uniprot id: G1QL60
names: Similarity
messages: Belongs to the TPP enzyme family.

61853:CD40LG
gene id: 61853:CD40LG
uniprot id: A0A2I3HMH8
uniprot id: G1QR70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

61853:LOC100585893
gene id: 61853:LOC100585893
uniprot id: G1QKL1
names: Similarity
messages: Belongs to the NUT family.

61853:PAQR6
gene id: 61853:PAQR6
uniprot id: A0A2I3GAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61853:CLDN14
gene id: 61853:CLDN14
uniprot id: G1QWU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:CRYGA
gene id: 61853:CRYGA
uniprot id: G1R676
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61853:RSBN1
gene id: 61853:RSBN1
uniprot id: G1QWQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

61853:MAATS1
gene id: 61853:MAATS1
uniprot id: G1QYU9
names: Similarity
messages: Belongs to the CFAP91 family.

61853:C17H7orf25
gene id: 61853:C17H7orf25
uniprot id: G1QSB6
names: Similarity
messages: Belongs to the UPF0415 family.

61853:LOC100590028
gene id: 61853:LOC100590028
uniprot id: G1S1P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:GDAP1
gene id: 61853:GDAP1
uniprot id: G1QM78
names: Similarity
messages: Belongs to the GST superfamily.

61853:ZNF330
gene id: 61853:ZNF330
uniprot id: A0A2I3GNS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

61853:SERPINB7
gene id: 61853:SERPINB7
uniprot id: A0A2I3GE21
uniprot id: G1RCD6
names: Similarity
messages: Belongs to the serpin family.

61853:SFRP4
gene id: 61853:SFRP4
uniprot id: A0A2I3H1X7
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MANEA
gene id: 61853:MANEA
uniprot id: G1RSS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:LOC100605310
gene id: 61853:LOC100605310
uniprot id: A0A2I3HWV8
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:CMC1
gene id: 61853:CMC1
uniprot id: G1QVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

61853:IWS1
gene id: 61853:IWS1
uniprot id: G1S0X5
names: Subcellular Location Annotation
messages: Nucleus

61853:HENMT1
gene id: 61853:HENMT1
uniprot id: G1QLX1
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

61853:RAF1
gene id: 61853:RAF1
uniprot id: G1QXT4
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

61853:ARHGEF6
gene id: 61853:ARHGEF6
uniprot id: G1QRL8
names: Subcellular Location Annotation
messages: lamellipodium

61853:TAF1A
gene id: 61853:TAF1A
uniprot id: M3ZBB8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

61853:AMPD3
gene id: 61853:AMPD3
uniprot id: A0A2I3HYP7
uniprot id: G1S766
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61853:TBX22
gene id: 61853:TBX22
uniprot id: G1QNW5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:TRIM10
gene id: 61853:TRIM10
uniprot id: A0A2I3GTA0
uniprot id: A0A2I3HVZ6
names: Similarity
names: Subunit
messages: Belongs to the TRIM/RBCC family.
messages: Interacts with IFNAR1; this interaction prevents association of IFNAR1 with TYK2.

61853:PIGK
gene id: 61853:PIGK
uniprot id: G1REU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C13 family.
messages: Endoplasmic reticulum membrane
messages: Forms a complex with PIGT, PIGS, PIGU and GAA1.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

61853:ATG12
gene id: 61853:ATG12
uniprot id: A0A2I3GKR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

61853:PIK3R3
gene id: 61853:PIK3R3
uniprot id: G1S3Y6
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

61853:CLCN2
gene id: 61853:CLCN2
uniprot id: A0A2I3G1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

61853:CLN5
gene id: 61853:CLN5
uniprot id: G1S2F8
names: Similarity
messages: Belongs to the CLN5 family.

61853:RTCA
gene id: 61853:RTCA
uniprot id: A0A2I3HIC5
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

61853:MED19
gene id: 61853:MED19
uniprot id: A0A2I3HZ58
uniprot id: G1RQS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:SLC25A36
gene id: 61853:SLC25A36
uniprot id: G1QX13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:SEC61A1
gene id: 61853:SEC61A1
uniprot id: G1RVT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:PPP1R11
gene id: 61853:PPP1R11
uniprot id: G1QYF6
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

61853:BTG1
gene id: 61853:BTG1
uniprot id: A0A2I3GMZ1
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

61853:MAPRE1
gene id: 61853:MAPRE1
uniprot id: G1RFI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

61853:SYBU
gene id: 61853:SYBU
uniprot id: G1QX08
names: Subcellular Location Annotation
messages: Membrane

61853:NKX2-6
gene id: 61853:NKX2-6
uniprot id: G1S1H0
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100582745
gene id: 61853:LOC100582745
uniprot id: G1SB41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:CDA
gene id: 61853:CDA
uniprot id: G1R8W9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

61853:XRN1
gene id: 61853:XRN1
uniprot id: M3ZBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm

61853:GSDMC
gene id: 61853:GSDMC
uniprot id: G1R0M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61853:PTHLH
gene id: 61853:PTHLH
uniprot id: A0A2I3G0E4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

61853:CPEB1
gene id: 61853:CPEB1
uniprot id: A0A2I3HDJ7
uniprot id: G1RJK7
names: Similarity
messages: Belongs to the RRM CPEB family.

61853:MARCHF4
gene id: 61853:MARCHF4
uniprot id: G1R6P1
names: Subcellular Location Annotation
messages: Membrane

61853:TGFB1
gene id: 61853:TGFB1
uniprot id: G1RTT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
messages: extracellular matrix

61853:NGLY1
gene id: 61853:NGLY1
uniprot id: A0A2I3GJU1
uniprot id: G1QUL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

61853:HSD17B3
gene id: 61853:HSD17B3
uniprot id: A0A2I3GAD3
uniprot id: A0A2I3H4W6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:NDUFS4
gene id: 61853:NDUFS4
uniprot id: G1RJN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

61853:ALG3
gene id: 61853:ALG3
uniprot id: G1R321
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:HMGB2
gene id: 61853:HMGB2
uniprot id: G1R4I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61853:JAGN1
gene id: 61853:JAGN1
uniprot id: G1QVZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:EPHA3
gene id: 61853:EPHA3
uniprot id: G1RM08
names: Subcellular Location Annotation
messages: Membrane

61853:GCM1
gene id: 61853:GCM1
uniprot id: G1QTM1
names: Subcellular Location Annotation
messages: Nucleus

61853:MAP2
gene id: 61853:MAP2
uniprot id: G1R6A0
names: Subcellular Location Annotation
messages: cytoskeleton

61853:PYGL
gene id: 61853:PYGL
uniprot id: G1RP19
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

61853:NDUFA8
gene id: 61853:NDUFA8
uniprot id: A0A2I3GUE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

61853:GET1
gene id: 61853:GET1
uniprot id: A0A2I3HMJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:DERL2
gene id: 61853:DERL2
uniprot id: G1RD08
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:TRPC4
gene id: 61853:TRPC4
uniprot id: A0A2I3GSH6
uniprot id: A0A2I3H8F3
uniprot id: A0A2I3HVM6
uniprot id: G1QQ58
names: Subcellular Location Annotation
messages: Membrane

61853:DPY19L3
gene id: 61853:DPY19L3
uniprot id: G1R7T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

61853:ATG4C
gene id: 61853:ATG4C
uniprot id: G1RYH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

61853:EGFL6
gene id: 61853:EGFL6
uniprot id: G1RD59
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SLC25A27
gene id: 61853:SLC25A27
uniprot id: G1QX17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:TAF10
gene id: 61853:TAF10
uniprot id: G1S6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

61853:MRPL35
gene id: 61853:MRPL35
uniprot id: A0A2I3GU82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

61853:LOC100585631
gene id: 61853:LOC100585631
uniprot id: A0A2I3HM59
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

61853:LOC100579420
gene id: 61853:LOC100579420
uniprot id: A0A2I3GIJ3
uniprot id: A0A2I3HC64
names: Similarity
messages: Belongs to the CBP3 family.

61853:REXO2
gene id: 61853:REXO2
uniprot id: A0A2I3GTF8
names: Similarity
messages: Belongs to the oligoribonuclease family.

61853:CLDND2
gene id: 61853:CLDND2
uniprot id: A0A2I3GEY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

61853:CMTM6
gene id: 61853:CMTM6
uniprot id: G1QW74
names: Subcellular Location Annotation
messages: Membrane

61853:MED10
gene id: 61853:MED10
uniprot id: A0A2I3H6E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:MRPS18A
gene id: 61853:MRPS18A
uniprot id: G1QUT7
names: Subcellular Location Annotation
messages: Mitochondrion

61853:RPS4X
gene id: 61853:RPS4X
uniprot id: G1S927
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

61853:RNF34
gene id: 61853:RNF34
uniprot id: A0A2I3G8S9
uniprot id: A0A2I3GZD9
names: Subcellular Location Annotation
messages: Cell membrane

61853:ALDH5A1
gene id: 61853:ALDH5A1
uniprot id: G1QNY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
messages: Homotetramer.
messages: Mitochondrion

61853:LIMS1
gene id: 61853:LIMS1
uniprot id: G1RJF7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

61853:CSF2
gene id: 61853:CSF2
uniprot id: G1RQ20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GM-CSF family.
messages: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
messages: Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
messages: Secreted

61853:ADA
gene id: 61853:ADA
uniprot id: A0A2I3HZE9
uniprot id: G1R4E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

61853:ZEB1
gene id: 61853:ZEB1
uniprot id: A0A2I3HC21
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

61853:LOC100599005
gene id: 61853:LOC100599005
uniprot id: A0A2I3HB07
uniprot id: G1QM39
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

61853:RAD50
gene id: 61853:RAD50
uniprot id: G1RQJ8
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

61853:STC1
gene id: 61853:STC1
uniprot id: G1S1I1
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

61853:TMEM41A
gene id: 61853:TMEM41A
uniprot id: G1R3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

61853:UBE2N
gene id: 61853:UBE2N
uniprot id: G1R126
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:NUBPL
gene id: 61853:NUBPL
uniprot id: G1QSA4
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

61853:TMEM30B
gene id: 61853:TMEM30B
uniprot id: A0A2I3HQV8
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

61853:CHGB
gene id: 61853:CHGB
uniprot id: G1RUK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

61853:LOC100583649
gene id: 61853:LOC100583649
uniprot id: G1S979
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:CMTM7
gene id: 61853:CMTM7
uniprot id: A0A2I3H1Y3
uniprot id: A0A2I3HFX0
names: Subcellular Location Annotation
messages: Membrane

61853:GPR161
gene id: 61853:GPR161
uniprot id: A0A2I3FY44
uniprot id: A0A2I3H0D1
uniprot id: A0A2I3HQ48
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:MRPL19
gene id: 61853:MRPL19
uniprot id: G1QKB4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

61853:C15H11orf58
gene id: 61853:C15H11orf58
uniprot id: A0A2I3HQ93
names: Similarity
messages: Belongs to the SMAP family.

61853:POU2F3
gene id: 61853:POU2F3
uniprot id: A0A2I3HPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

61853:CYLD
gene id: 61853:CYLD
uniprot id: G1QJS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: centrosome
messages: cilium basal body
messages: perinuclear region
messages: spindle

61853:ZDHHC13
gene id: 61853:ZDHHC13
uniprot id: G1S7X6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:FKBP6
gene id: 61853:FKBP6
uniprot id: G1RCK1
names: Function
names: Similarity
messages: Belongs to the FKBP6 family.
messages: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

61853:ERCC5
gene id: 61853:ERCC5
uniprot id: G1R8Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

61853:SMNDC1
gene id: 61853:SMNDC1
uniprot id: G1RZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

61853:RPN2
gene id: 61853:RPN2
uniprot id: G1R331
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

61853:LOC100583243
gene id: 61853:LOC100583243
uniprot id: A0A2I3HBL3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:DEFB119
gene id: 61853:DEFB119
uniprot id: A0A2I3HW98
uniprot id: G1REJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:TCTEX1D4
gene id: 61853:TCTEX1D4
uniprot id: G1RVD1
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61853:SOD3
gene id: 61853:SOD3
uniprot id: A0A2I3GYD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

61853:IRF2BP1
gene id: 61853:IRF2BP1
uniprot id: G1S9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

61853:IL21
gene id: 61853:IL21
uniprot id: G1RE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

61853:LOC100597637
gene id: 61853:LOC100597637
uniprot id: G1SAW5
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:LOC100581237
gene id: 61853:LOC100581237
uniprot id: G1RBS8
names: Similarity
messages: Belongs to the ficolin lectin family.

61853:ME1
gene id: 61853:ME1
uniprot id: G1RQ93
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

61853:FZD5
gene id: 61853:FZD5
uniprot id: A0A2I3HUS3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:EBF2
gene id: 61853:EBF2
uniprot id: G1S2A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61853:CLCN3
gene id: 61853:CLCN3
uniprot id: A0A2I3HG94
uniprot id: G1R4F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61853:HTRA4
gene id: 61853:HTRA4
uniprot id: A0A2I3HVB1
names: Similarity
messages: Belongs to the peptidase S1C family.

61853:EBP
gene id: 61853:EBP
uniprot id: G1R8J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:ATP6V1H
gene id: 61853:ATP6V1H
uniprot id: A0A2I3H1J4
uniprot id: G1QJL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61853:PPDPFL
gene id: 61853:PPDPFL
uniprot id: A0A2I3GD11
names: Similarity
messages: Belongs to the PPDPF family.

61853:YIPF6
gene id: 61853:YIPF6
uniprot id: A0A2I3HW51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

61853:MS4A6A
gene id: 61853:MS4A6A
uniprot id: G1RSC2
names: Function
names: Similarity
messages: Belongs to the MS4A family.
messages: May be involved in signal transduction as a component of a multimeric receptor complex.

61853:DHRS4
gene id: 61853:DHRS4
uniprot id: G1RYS3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:LOC100603983
gene id: 61853:LOC100603983
uniprot id: G1SA62
names: Function
names: Subunit
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

61853:RTN1
gene id: 61853:RTN1
uniprot id: A0A2I3GKR8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:SNX20
gene id: 61853:SNX20
uniprot id: A0A2I3GVR7
uniprot id: A0A2I3H4E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

61853:NAT2
gene id: 61853:NAT2
uniprot id: G1QS63
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

61853:DDI1
gene id: 61853:DDI1
uniprot id: G1SC27
names: Similarity
messages: Belongs to the DDI1 family.

61853:NID1
gene id: 61853:NID1
uniprot id: G1QSA1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

61853:SLCO1C1
gene id: 61853:SLCO1C1
uniprot id: G1QXI9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:FAM199X
gene id: 61853:FAM199X
uniprot id: G1RTF1
names: Similarity
messages: Belongs to the FAM199 family.

61853:CAV1
gene id: 61853:CAV1
uniprot id: A0A2I3GLN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: Membrane raft
messages: caveola

61853:POLR1D
gene id: 61853:POLR1D
uniprot id: G1QHN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

61853:SCGN
gene id: 61853:SCGN
uniprot id: G1QR71
names: Subcellular Location Annotation
messages: secretory vesicle membrane

61853:GRM1
gene id: 61853:GRM1
uniprot id: A0A2I3GBH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

61853:ABI1
gene id: 61853:ABI1
uniprot id: A0A2I3H2B2
uniprot id: A0A2I3H962
uniprot id: A0A2I3HGF8
uniprot id: A0A2I3HWN0
uniprot id: A0A2I3HXX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

61853:PAF1
gene id: 61853:PAF1
uniprot id: G1RWE9
names: Similarity
messages: Belongs to the PAF1 family.

61853:RPS7
gene id: 61853:RPS7
uniprot id: A0A2I3GS23
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Required for rRNA maturation.

61853:SLC46A2
gene id: 61853:SLC46A2
uniprot id: G1S3L5
names: Subcellular Location Annotation
messages: Membrane

61853:ANXA10
gene id: 61853:ANXA10
uniprot id: G1R430
names: Similarity
messages: Belongs to the annexin family.

61853:POLRMT
gene id: 61853:POLRMT
uniprot id: G1QJ40
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61853:PRKCG
gene id: 61853:PRKCG
uniprot id: G1R2Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

61853:SLC15A3
gene id: 61853:SLC15A3
uniprot id: G1RTR4
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

61853:GRB2
gene id: 61853:GRB2
uniprot id: A0A2I3HAR1
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

61853:CNN3
gene id: 61853:CNN3
uniprot id: A0A2I3HF96
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

61853:MOSPD1
gene id: 61853:MOSPD1
uniprot id: A0A2I3GEQ7
uniprot id: G1QNS5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

61853:ACP1
gene id: 61853:ACP1
uniprot id: A0A2I3GWY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

61853:TRNAU1AP
gene id: 61853:TRNAU1AP
uniprot id: G1RFG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

61853:DEFB132
gene id: 61853:DEFB132
uniprot id: G1REG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:LOC100590651
gene id: 61853:LOC100590651
uniprot id: G1SC60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:MDM2
gene id: 61853:MDM2
uniprot id: A0A2I3G0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

61853:TASOR
gene id: 61853:TASOR
uniprot id: A0A2I3FZV1
uniprot id: G1R6L5
names: Similarity
messages: Belongs to the TASOR family.

61853:ENPP3
gene id: 61853:ENPP3
uniprot id: G1RWL2
names: Subcellular Location Annotation
messages: Secreted

61853:AFG1L
gene id: 61853:AFG1L
uniprot id: G1RTK2
names: Similarity
messages: Belongs to the AFG1 ATPase family.

61853:HSPA13
gene id: 61853:HSPA13
uniprot id: G1QML3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

61853:C23H8orf33
gene id: 61853:C23H8orf33
uniprot id: G1RJN0
names: Similarity
messages: Belongs to the UPF0488 family.

61853:LOC100579421
gene id: 61853:LOC100579421
uniprot id: G1S977
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:F2R
gene id: 61853:F2R
uniprot id: G1RQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ADHFE1
gene id: 61853:ADHFE1
uniprot id: G1RIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

61853:LOC100596198
gene id: 61853:LOC100596198
uniprot id: A0A2I3HPE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61853:EPN2
gene id: 61853:EPN2
uniprot id: G1RBQ9
names: Similarity
messages: Belongs to the epsin family.

61853:TM7SF3
gene id: 61853:TM7SF3
uniprot id: G1R044
names: Subcellular Location Annotation
messages: Membrane

61853:CAV3
gene id: 61853:CAV3
uniprot id: G1QUD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

61853:DESI2
gene id: 61853:DESI2
uniprot id: G1QV90
names: Similarity
messages: Belongs to the DeSI family.

61853:PIGZ
gene id: 61853:PIGZ
uniprot id: G1QMF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:FOXA3
gene id: 61853:FOXA3
uniprot id: G1QPL9
names: Subcellular Location Annotation
messages: Nucleus

61853:LAMTOR2
gene id: 61853:LAMTOR2
uniprot id: A0A2I3G399
uniprot id: A0A2I3GK13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

61853:AGT
gene id: 61853:AGT
uniprot id: G1QMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

61853:LOC100587665
gene id: 61853:LOC100587665
uniprot id: A0A2I3HER1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:NEFL
gene id: 61853:NEFL
uniprot id: G1S1T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: cytoskeleton

61853:GPHA2
gene id: 61853:GPHA2
uniprot id: G1R030
names: Caution
names: Similarity
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SAP30
gene id: 61853:SAP30
uniprot id: A0A2I3GSW2
names: Similarity
messages: Belongs to the SAP30 family.

61853:TUBGCP4
gene id: 61853:TUBGCP4
uniprot id: G1QYN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

61853:DPYD
gene id: 61853:DPYD
uniprot id: G1RKT4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.
messages: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
messages: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

61853:ESCO2
gene id: 61853:ESCO2
uniprot id: G1S3H2
names: Subcellular Location Annotation
messages: Nucleus

61853:LEPROT
gene id: 61853:LEPROT
uniprot id: A0A2I3HI55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

61853:DMC1
gene id: 61853:DMC1
uniprot id: G1RYR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

61853:TMEM14B
gene id: 61853:TMEM14B
uniprot id: G1QIG2
names: Similarity
messages: Belongs to the TMEM14 family.

61853:RIDA
gene id: 61853:RIDA
uniprot id: A0A2I3GN25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

61853:STAMBP
gene id: 61853:STAMBP
uniprot id: G1QHI7
names: Similarity
messages: Belongs to the peptidase M67C family.

61853:PAX3
gene id: 61853:PAX3
uniprot id: G1REQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61853:PAN3
gene id: 61853:PAN3
uniprot id: A0A2I3HWC7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

61853:GPR37L1
gene id: 61853:GPR37L1
uniprot id: G1S8Y8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:INO80C
gene id: 61853:INO80C
uniprot id: A0A2I3GTU0
uniprot id: A0A2I3HZT3
names: Subcellular Location Annotation
messages: Nucleus

61853:DYNC1LI1
gene id: 61853:DYNC1LI1
uniprot id: G1QWD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

61853:TARS3
gene id: 61853:TARS3
uniprot id: A0A2I3HKZ5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61853:HAO1
gene id: 61853:HAO1
uniprot id: G1RV60
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

61853:LOC100592631
gene id: 61853:LOC100592631
uniprot id: A0A2I3GIL3
names: Similarity
messages: Belongs to the peptidase M16 family.

61853:NR0B1
gene id: 61853:NR0B1
uniprot id: G1RGF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

61853:DHDDS
gene id: 61853:DHDDS
uniprot id: A0A2I3HM77
uniprot id: G1RDN6
names: Similarity
messages: Belongs to the UPP synthase family.

61853:LOC100593802
gene id: 61853:LOC100593802
uniprot id: G1SAV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:CXCL12
gene id: 61853:CXCL12
uniprot id: A0A2I3GFF0
uniprot id: A0A2I3H6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:INIP
gene id: 61853:INIP
uniprot id: G1S3J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

61853:OXR1
gene id: 61853:OXR1
uniprot id: A0A2I3GYC8
uniprot id: A0A2I3H5H2
uniprot id: G1QVC1
names: Similarity
messages: Belongs to the OXR1 family.

61853:MCUB
gene id: 61853:MCUB
uniprot id: G1S3N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

61853:F10
gene id: 61853:F10
uniprot id: G1QI58
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:CDKN1B
gene id: 61853:CDKN1B
uniprot id: G1QTS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

61853:DNAJA1
gene id: 61853:DNAJA1
uniprot id: G1QZM9
names: Subcellular Location Annotation
messages: Membrane

61853:NNAT
gene id: 61853:NNAT
uniprot id: A0A2I3HMZ0
uniprot id: G1R369
names: Similarity
messages: Belongs to the neuronatin family.

61853:AJAP1
gene id: 61853:AJAP1
uniprot id: G1R9N6
names: Subcellular Location Annotation
messages: Membrane

61853:DNAAF4
gene id: 61853:DNAAF4
uniprot id: A0A2I3GAS4
uniprot id: A0A2I3GXT7
uniprot id: G1R4D0
names: Subcellular Location Annotation
messages: Dynein axonemal particle
messages: neuron projection

61853:SLC6A14
gene id: 61853:SLC6A14
uniprot id: G1RXD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61853:ALX1
gene id: 61853:ALX1
uniprot id: G1QZZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61853:UBE2T
gene id: 61853:UBE2T
uniprot id: G1S8Z3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:STK38
gene id: 61853:STK38
uniprot id: G1RIH6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:TANGO6
gene id: 61853:TANGO6
uniprot id: G1R018
names: Similarity
messages: Belongs to the Tango6 family.

61853:SASS6
gene id: 61853:SASS6
uniprot id: G1RM01
names: Subcellular Location Annotation
messages: centrosome

61853:VPS29
gene id: 61853:VPS29
uniprot id: A0A2I3GK26
uniprot id: A0A2I3GPG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

61853:LIN9
gene id: 61853:LIN9
uniprot id: G1RUE6
names: Similarity
messages: Belongs to the lin-9 family.

61853:OLFML2B
gene id: 61853:OLFML2B
uniprot id: G1RWS1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LXN
gene id: 61853:LXN
uniprot id: A0A2I3GPH9
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

61853:CPXM2
gene id: 61853:CPXM2
uniprot id: G1S5D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

61853:PNLIPRP3
gene id: 61853:PNLIPRP3
uniprot id: G1S321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61853:PARD6B
gene id: 61853:PARD6B
uniprot id: G1R5Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

61853:VEGFD
gene id: 61853:VEGFD
uniprot id: G1RDV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

61853:FMO4
gene id: 61853:FMO4
uniprot id: G1RYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61853:CDKN2AIPNL
gene id: 61853:CDKN2AIPNL
uniprot id: A0A2I3GBS8
names: Similarity
messages: Belongs to the CARF family.

61853:MPP3
gene id: 61853:MPP3
uniprot id: A0A2I3GIR2
names: Similarity
messages: Belongs to the MAGUK family.

61853:SYPL2
gene id: 61853:SYPL2
uniprot id: G1QRC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61853:GCSH
gene id: 61853:GCSH
uniprot id: A0A2I3GIN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

61853:CWC15
gene id: 61853:CWC15
uniprot id: A0A2I3HUF5
names: Similarity
messages: Belongs to the CWC15 family.

61853:CCT4
gene id: 61853:CCT4
uniprot id: G1RF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

61853:POLR2M
gene id: 61853:POLR2M
uniprot id: G1RKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

61853:ENPP4
gene id: 61853:ENPP4
uniprot id: G1QTR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

61853:SUGCT
gene id: 61853:SUGCT
uniprot id: G1QS87
names: Similarity
messages: Belongs to the CoA-transferase III family.

61853:RAB32
gene id: 61853:RAB32
uniprot id: A0A2I3H8M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

61853:GRPEL1
gene id: 61853:GRPEL1
uniprot id: G1RMB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

61853:PCBD2
gene id: 61853:PCBD2
uniprot id: A0A2I3H4V4
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

61853:SIVA1
gene id: 61853:SIVA1
uniprot id: G1S2S9
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

61853:LANCL1
gene id: 61853:LANCL1
uniprot id: G1R6D9
names: Similarity
messages: Belongs to the LanC-like protein family.

61853:NPM1
gene id: 61853:NPM1
uniprot id: A0A2I3HRX0
uniprot id: G1QHL3
names: Similarity
messages: Belongs to the nucleoplasmin family.

61853:B4GALNT1
gene id: 61853:B4GALNT1
uniprot id: G1S612
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:PON3
gene id: 61853:PON3
uniprot id: G1S0T5
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

61853:RIC8B
gene id: 61853:RIC8B
uniprot id: A0A2I3G2X8
uniprot id: A0A2I3HPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the synembryn family.
messages: Cytoplasm
messages: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.
messages: Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

61853:CCNT1
gene id: 61853:CCNT1
uniprot id: G1S877
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

61853:NOP56
gene id: 61853:NOP56
uniprot id: G1RD85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

61853:EIF4EBP2
gene id: 61853:EIF4EBP2
uniprot id: G1S205
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

61853:GPR37
gene id: 61853:GPR37
uniprot id: G1RNJ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:PLAC8L1
gene id: 61853:PLAC8L1
uniprot id: G1RFF3
names: Similarity
messages: Belongs to the cornifelin family.

61853:ACAD9
gene id: 61853:ACAD9
uniprot id: G1RWC4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61853:SLC25A26
gene id: 61853:SLC25A26
uniprot id: G1R7J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:TOP2B
gene id: 61853:TOP2B
uniprot id: A0A2I3H296
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

61853:CLDN17
gene id: 61853:CLDN17
uniprot id: G1SA44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:RANGRF
gene id: 61853:RANGRF
uniprot id: A0A2I3GLJ3
names: Similarity
messages: Belongs to the MOG1 family.

61853:SNX14
gene id: 61853:SNX14
uniprot id: A0A2I3GGM8
names: Similarity
messages: Belongs to the sorting nexin family.

61853:TOMM40L
gene id: 61853:TOMM40L
uniprot id: A0A2I3HEC8
uniprot id: G1RVR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

61853:HUS1
gene id: 61853:HUS1
uniprot id: A0A2I3HMZ4
names: Similarity
messages: Belongs to the HUS1 family.

61853:TNFSF12
gene id: 61853:TNFSF12
uniprot id: A0A2I3GUT7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61853:PIGH
gene id: 61853:PIGH
uniprot id: G1QIV9
names: Similarity
messages: Belongs to the PIGH family.

61853:CERS2
gene id: 61853:CERS2
uniprot id: G1RG72
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61853:YWHAH
gene id: 61853:YWHAH
uniprot id: G1QXX5
names: Similarity
messages: Belongs to the 14-3-3 family.

61853:LOC100585215
gene id: 61853:LOC100585215
uniprot id: G1RHY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61853:LNPEP
gene id: 61853:LNPEP
uniprot id: G1RWG3
names: Similarity
messages: Belongs to the peptidase M1 family.

61853:DLK2
gene id: 61853:DLK2
uniprot id: A0A2I3HJM8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:ALPG
gene id: 61853:ALPG
uniprot id: G1RVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

61853:MRPS24
gene id: 61853:MRPS24
uniprot id: A0A2I3HIE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

61853:CEP19
gene id: 61853:CEP19
uniprot id: M3Z926
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

61853:SPG21
gene id: 61853:SPG21
uniprot id: A0A2I3HT09
names: Function
names: Subunit
messages: Interacts with CD4. Interacts with ALDH16A1.
messages: May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

61853:FAM241A
gene id: 61853:FAM241A
uniprot id: G1S380
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

61853:RHOXF2
gene id: 61853:RHOXF2
uniprot id: A0A2I3HAY5
names: Subcellular Location Annotation
messages: Nucleus

61853:PFDN5
gene id: 61853:PFDN5
uniprot id: A0A2I3HVV0
uniprot id: G1S7K1
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

61853:NUDT12
gene id: 61853:NUDT12
uniprot id: G1RK38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

61853:SLC17A6
gene id: 61853:SLC17A6
uniprot id: G1S827
names: Subcellular Location Annotation
messages: Membrane

61853:SRP19
gene id: 61853:SRP19
uniprot id: A0A2I3HU51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

61853:LTN1
gene id: 61853:LTN1
uniprot id: G1QRP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

61853:RCAN1
gene id: 61853:RCAN1
uniprot id: A0A2I3G8X2
uniprot id: A0A2I3H869
names: Similarity
messages: Belongs to the RCAN family.

61853:CTBS
gene id: 61853:CTBS
uniprot id: G1RFY0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

61853:GCNT2
gene id: 61853:GCNT2
uniprot id: A0A2I3GIE0
uniprot id: G1QI76
uniprot id: M3ZBD0
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61853:HSPA6
gene id: 61853:HSPA6
uniprot id: G1SBW1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61853:TMEM170A
gene id: 61853:TMEM170A
uniprot id: G1RRF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

61853:ASPHD2
gene id: 61853:ASPHD2
uniprot id: G1R867
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

61853:BCCIP
gene id: 61853:BCCIP
uniprot id: A0A2I3GXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

61853:GTF2H3
gene id: 61853:GTF2H3
uniprot id: A0A2I3HFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

61853:WNT10A
gene id: 61853:WNT10A
uniprot id: G1RCL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:LOC100604545
gene id: 61853:LOC100604545
uniprot id: G1RHM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Membrane
messages: Mitochondrion inner membrane

61853:TSC22D3
gene id: 61853:TSC22D3
uniprot id: A0A2I3HKB6
uniprot id: A0A2I3I045
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61853:MTMR7
gene id: 61853:MTMR7
uniprot id: G1QQL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

61853:MPP1
gene id: 61853:MPP1
uniprot id: G1RWA1
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

61853:LOC100595948
gene id: 61853:LOC100595948
uniprot id: G1S2R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

61853:DMRT1
gene id: 61853:DMRT1
uniprot id: G1RB29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61853:RELL1
gene id: 61853:RELL1
uniprot id: A0A2I3HXU9
names: Similarity
messages: Belongs to the RELT family.

61853:CASP4
gene id: 61853:CASP4
uniprot id: G1R6F5
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:HOMER1
gene id: 61853:HOMER1
uniprot id: G1RQW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

61853:FITM1
gene id: 61853:FITM1
uniprot id: G1RZ12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. FIT1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol.

61853:IL1RAPL1
gene id: 61853:IL1RAPL1
uniprot id: G1RGF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the interleukin-1 receptor family.
messages: axon
messages: dendrite

61853:AKAP5
gene id: 61853:AKAP5
uniprot id: G1SBT7
names: Subcellular Location Annotation
messages: Membrane

61853:THUMPD2
gene id: 61853:THUMPD2
uniprot id: G1S3L4
names: Similarity
messages: Belongs to the methyltransferase superfamily.

61853:CD37
gene id: 61853:CD37
uniprot id: A0A2I3G0K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:AQR
gene id: 61853:AQR
uniprot id: G1RK35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWF11 family.
messages: Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
messages: Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
messages: Nucleus

61853:ACTN4
gene id: 61853:ACTN4
uniprot id: A0A2I3GQL4
uniprot id: G1S4J1
names: Similarity
messages: Belongs to the alpha-actinin family.

61853:MRPS21
gene id: 61853:MRPS21
uniprot id: A0A2I3GDL4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

61853:ND4L
gene id: 61853:ND4L
uniprot id: E7EAD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

61853:PEX16
gene id: 61853:PEX16
uniprot id: A0A2I3HUQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

61853:ECHDC1
gene id: 61853:ECHDC1
uniprot id: A0A2I3HF69
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

61853:TCAF1
gene id: 61853:TCAF1
uniprot id: G1QT46
names: Similarity
messages: Belongs to the TCAF family.

61853:TMEM176B
gene id: 61853:TMEM176B
uniprot id: A0A2I3H333
uniprot id: G1QUS6
names: Similarity
messages: Belongs to the TMEM176 family.

61853:CACYBP
gene id: 61853:CACYBP
uniprot id: G1RZI0
names: Function
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

61853:ARL3
gene id: 61853:ARL3
uniprot id: G1RYW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

61853:UTS2B
gene id: 61853:UTS2B
uniprot id: G1R4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

61853:DEFB118
gene id: 61853:DEFB118
uniprot id: G1REI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:BLK
gene id: 61853:BLK
uniprot id: M3ZCN7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61853:FAM187B
gene id: 61853:FAM187B
uniprot id: G1RJP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

61853:LOC100592247
gene id: 61853:LOC100592247
uniprot id: G1S987
names: Subcellular Location Annotation
messages: Membrane

61853:CASP10
gene id: 61853:CASP10
uniprot id: G1R5K0
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:RBM8A
gene id: 61853:RBM8A
uniprot id: A0A2I3I026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

61853:SEC22B
gene id: 61853:SEC22B
uniprot id: G1R0D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

61853:LOC100586323
gene id: 61853:LOC100586323
uniprot id: A0A2I3GDE3
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:ODAM
gene id: 61853:ODAM
uniprot id: G1R7Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ODAM family.
messages: Cytoplasm
messages: Interacts (via C-terminus) with ARHGEF5.
messages: Nucleus
messages: Secreted
messages: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

61853:LOC100583040
gene id: 61853:LOC100583040
uniprot id: G1S2P6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:GSG1
gene id: 61853:GSG1
uniprot id: A0A2I3GV41
uniprot id: A0A2I3HCH4
uniprot id: G1QUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

61853:DCLK1
gene id: 61853:DCLK1
uniprot id: A0A2I3FX12
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:LIN28B
gene id: 61853:LIN28B
uniprot id: G1RVA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

61853:VPS26C
gene id: 61853:VPS26C
uniprot id: A0A2I3H7C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

61853:XRN2
gene id: 61853:XRN2
uniprot id: G1RG93
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

61853:SLC39A2
gene id: 61853:SLC39A2
uniprot id: G1RUZ1
names: Subcellular Location Annotation
messages: Membrane

61853:SLC25A19
gene id: 61853:SLC25A19
uniprot id: G1QJA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:CBX8
gene id: 61853:CBX8
uniprot id: G1QH15
names: Subcellular Location Annotation
messages: Nucleus

61853:AP4S1
gene id: 61853:AP4S1
uniprot id: A0A2I3HNQ4
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

61853:NMI
gene id: 61853:NMI
uniprot id: G1RJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

61853:FAM13A
gene id: 61853:FAM13A
uniprot id: A0A2I3GGW3
uniprot id: A0A2I3GH50
uniprot id: A0A2I3I090
names: Similarity
messages: Belongs to the FAM13 family.

61853:LOC100600196
gene id: 61853:LOC100600196
uniprot id: A0A2I3G8J0
names: Similarity
messages: Belongs to the histone H2B family.

61853:SLC35A5
gene id: 61853:SLC35A5
uniprot id: A0A2I3HBA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

61853:RORB
gene id: 61853:RORB
uniprot id: G1QLC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61853:PRL
gene id: 61853:PRL
uniprot id: G1QMP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

61853:ZKSCAN7
gene id: 61853:ZKSCAN7
uniprot id: A0A2I3HLF5
names: Subcellular Location Annotation
messages: Nucleus

61853:GPR65
gene id: 61853:GPR65
uniprot id: G1S4R8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:USP20
gene id: 61853:USP20
uniprot id: G1S7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

61853:LOC100605912
gene id: 61853:LOC100605912
uniprot id: G1R5B0
uniprot id: G1SAF6
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

61853:P2RY1
gene id: 61853:P2RY1
uniprot id: G1SBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PTER
gene id: 61853:PTER
uniprot id: G1RPD6
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CMBL
gene id: 61853:CMBL
uniprot id: G1RLJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

61853:TMEM168
gene id: 61853:TMEM168
uniprot id: G1RKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

61853:THOC6
gene id: 61853:THOC6
uniprot id: A0A2I3GIG0
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

61853:OTULIN
gene id: 61853:OTULIN
uniprot id: G1RMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

61853:GCM2
gene id: 61853:GCM2
uniprot id: G1QIM5
names: Subcellular Location Annotation
messages: Nucleus

61853:NEXMIF
gene id: 61853:NEXMIF
uniprot id: G1QJZ4
names: Subcellular Location Annotation
messages: Nucleus

61853:P2RX1
gene id: 61853:P2RX1
uniprot id: G1S670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61853:HNRNPK
gene id: 61853:HNRNPK
uniprot id: G1QTU8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

61853:FGF13
gene id: 61853:FGF13
uniprot id: A0A2I3FQR4
uniprot id: A0A2I3HH88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

61853:STC2
gene id: 61853:STC2
uniprot id: G1QI14
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

61853:FAM83A
gene id: 61853:FAM83A
uniprot id: A0A2I3GYT9
uniprot id: A0A2I3H2T9
uniprot id: G1QZM1
names: Similarity
messages: Belongs to the FAM83 family.

61853:ADCY5
gene id: 61853:ADCY5
uniprot id: A0A2I3HXJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

61853:VAMP3
gene id: 61853:VAMP3
uniprot id: A0A2I3G5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61853:TMEM163
gene id: 61853:TMEM163
uniprot id: G1RAH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: May bind zinc and other divalent cations and recruit them to vesicular organelles.
messages: Membrane
messages: synaptic vesicle membrane

61853:HRK
gene id: 61853:HRK
uniprot id: G1QHD8
names: Function
names: Subcellular Location Annotation
messages: Mitochondrion
messages: Promotes apoptosis.

61853:TRAPPC4
gene id: 61853:TRAPPC4
uniprot id: A0A2I3GLC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

61853:STX10
gene id: 61853:STX10
uniprot id: A0A2I3H0J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

61853:WNT3A
gene id: 61853:WNT3A
uniprot id: A0A2I3G281
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:CA13
gene id: 61853:CA13
uniprot id: A0A2I3GS17
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61853:LOC100591193
gene id: 61853:LOC100591193
uniprot id: G1S9R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:METTL11B
gene id: 61853:METTL11B
uniprot id: G1RYN4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

61853:TRIM54
gene id: 61853:TRIM54
uniprot id: G1QSL2
names: Function
names: Subcellular Location Annotation
messages: May bind and stabilize microtubules during myotubes formation.
messages: Z line

61853:MAB21L2
gene id: 61853:MAB21L2
uniprot id: G1SAJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

61853:PDE6A
gene id: 61853:PDE6A
uniprot id: A0A2I3HF42
uniprot id: G1RGT6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:SH3BP4
gene id: 61853:SH3BP4
uniprot id: G1RB37
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

61853:IFNGR1
gene id: 61853:IFNGR1
uniprot id: A0A2I3H3K8
names: Similarity
messages: Belongs to the type II cytokine receptor family.

61853:UBR2
gene id: 61853:UBR2
uniprot id: G1QXU9
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

61853:POU4F2
gene id: 61853:POU4F2
uniprot id: G1R0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

61853:PNPLA1
gene id: 61853:PNPLA1
uniprot id: G1RCT3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SLC7A14
gene id: 61853:SLC7A14
uniprot id: G1QZL3
names: Subcellular Location Annotation
messages: Membrane

61853:CLDN11
gene id: 61853:CLDN11
uniprot id: G1QZK3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:CSGALNACT2
gene id: 61853:CSGALNACT2
uniprot id: A0A2I3FQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

61853:RNF141
gene id: 61853:RNF141
uniprot id: G1S770
names: Function
messages: May be involved in spermatogenesis.

61853:PLSCR5
gene id: 61853:PLSCR5
uniprot id: A0A2I3GQF8
uniprot id: G1QPH9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61853:RABAC1
gene id: 61853:RABAC1
uniprot id: G1RST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

61853:LOC100581301
gene id: 61853:LOC100581301
uniprot id: G1S978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ACAT1
gene id: 61853:ACAT1
uniprot id: G1R6J0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61853:TENM2
gene id: 61853:TENM2
uniprot id: A0A2I3GI61
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:EED
gene id: 61853:EED
uniprot id: A0A2I3GHZ6
uniprot id: G1S2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

61853:PTPRZ1
gene id: 61853:PTPRZ1
uniprot id: G1RMS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

61853:FREM2
gene id: 61853:FREM2
uniprot id: G1QQA3
names: Similarity
messages: Belongs to the FRAS1 family.

61853:TM9SF4
gene id: 61853:TM9SF4
uniprot id: G1RFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

61853:UBE2D2
gene id: 61853:UBE2D2
uniprot id: A0A2I3GKM9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:TFCP2
gene id: 61853:TFCP2
uniprot id: G1S7V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61853:APH1B
gene id: 61853:APH1B
uniprot id: G1RNR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

61853:FAAH
gene id: 61853:FAAH
uniprot id: G1S3D7
names: Similarity
messages: Belongs to the amidase family.

61853:CBFB
gene id: 61853:CBFB
uniprot id: G1QW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

61853:LOC100607862
gene id: 61853:LOC100607862
uniprot id: G1S975
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:NPM3
gene id: 61853:NPM3
uniprot id: A0A2I3FYH6
names: Similarity
messages: Belongs to the nucleoplasmin family.

61853:CHMP2B
gene id: 61853:CHMP2B
uniprot id: A0A2I3HLR0
names: Similarity
messages: Belongs to the SNF7 family.

61853:SYCE1
gene id: 61853:SYCE1
uniprot id: A0A2I3GZP3
uniprot id: G1QQH7
names: Similarity
messages: Belongs to the SYCE family.

61853:PTPN13
gene id: 61853:PTPN13
uniprot id: A0A2I3G8U4
uniprot id: A0A2I3GNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

61853:LOC100597957
gene id: 61853:LOC100597957
uniprot id: A0A7R8GUU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:STOM
gene id: 61853:STOM
uniprot id: A0A2I3GGF0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

61853:LMOD2
gene id: 61853:LMOD2
uniprot id: G1RND7
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

61853:HIKESHI
gene id: 61853:HIKESHI
uniprot id: G1S2D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

61853:TMPRSS7
gene id: 61853:TMPRSS7
uniprot id: G1QVW4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:APCS
gene id: 61853:APCS
uniprot id: G1RS30
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

61853:CLEC10A
gene id: 61853:CLEC10A
uniprot id: G1RDT8
names: Subcellular Location Annotation
messages: Membrane

61853:ERGIC1
gene id: 61853:ERGIC1
uniprot id: G1QHW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

61853:DTNBP1
gene id: 61853:DTNBP1
uniprot id: A0A2I3GC51
names: Similarity
messages: Belongs to the dysbindin family.

61853:ATP5IF1
gene id: 61853:ATP5IF1
uniprot id: A0A2I3H1P7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

61853:MFAP1
gene id: 61853:MFAP1
uniprot id: A0A2I3HR20
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

61853:SLC6A2
gene id: 61853:SLC6A2
uniprot id: A0A2I3GAK2
uniprot id: G1QLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61853:RFT1
gene id: 61853:RFT1
uniprot id: A0A2I3HVW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

61853:SYT17
gene id: 61853:SYT17
uniprot id: A0A2I3H1N6
uniprot id: A0A2I3HPE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

61853:ALG11
gene id: 61853:ALG11
uniprot id: A0A2I3GFA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

61853:KCNJ6
gene id: 61853:KCNJ6
uniprot id: A0A2I3HQ04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

61853:OSBPL10
gene id: 61853:OSBPL10
uniprot id: G1QW23
names: Similarity
messages: Belongs to the OSBP family.

61853:FARSB
gene id: 61853:FARSB
uniprot id: A0A2I3GYC0
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

61853:CDC42EP2
gene id: 61853:CDC42EP2
uniprot id: A0A2I3GWI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

61853:NT5C3A
gene id: 61853:NT5C3A
uniprot id: G1RZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

61853:EGF
gene id: 61853:EGF
uniprot id: A0A2I3GH31
uniprot id: A0A2I3HAR9
uniprot id: G1S3J7
names: Caution
names: Function
names: Subunit
messages: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
messages: Interacts with EGFR and promotes EGFR dimerization.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:FICD
gene id: 61853:FICD
uniprot id: G1R4W1
names: Similarity
messages: Belongs to the fic family.

61853:GALC
gene id: 61853:GALC
uniprot id: G1S4R5
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

61853:BORCS7
gene id: 61853:BORCS7
uniprot id: A0A2I3GZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

61853:GNG12
gene id: 61853:GNG12
uniprot id: A0A2I3H7I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61853:DONSON
gene id: 61853:DONSON
uniprot id: G1QVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

61853:SLC35A1
gene id: 61853:SLC35A1
uniprot id: A0A2I3HTQ1
uniprot id: G1RR48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

61853:BLCAP
gene id: 61853:BLCAP
uniprot id: A0A2I3GB38
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

61853:IRAK1BP1
gene id: 61853:IRAK1BP1
uniprot id: A0A2I3GRK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

61853:BST1
gene id: 61853:BST1
uniprot id: G1S308
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

61853:TSPAN7
gene id: 61853:TSPAN7
uniprot id: A0A2I3G9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:BCAS2
gene id: 61853:BCAS2
uniprot id: G1QXT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

61853:ITGB3
gene id: 61853:ITGB3
uniprot id: G1QXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61853:FGD1
gene id: 61853:FGD1
uniprot id: G1S2D9
names: Subcellular Location Annotation
messages: cytoskeleton

61853:FOLR3
gene id: 61853:FOLR3
uniprot id: G1S5Y4
names: Similarity
messages: Belongs to the folate receptor family.

61853:CXCL14
gene id: 61853:CXCL14
uniprot id: G1RA03
names: Subcellular Location Annotation
messages: Secreted

61853:MLN
gene id: 61853:MLN
uniprot id: G1RAS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

61853:HOXD4
gene id: 61853:HOXD4
uniprot id: G1R255
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61853:GABPA
gene id: 61853:GABPA
uniprot id: G1QQ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:ADD2
gene id: 61853:ADD2
uniprot id: A0A2I3GJ27
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

61853:NR5A1
gene id: 61853:NR5A1
uniprot id: G1S650
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

61853:SCG5
gene id: 61853:SCG5
uniprot id: G1RIB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

61853:LIPA
gene id: 61853:LIPA
uniprot id: A0A2I3GTS6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61853:FBXO45
gene id: 61853:FBXO45
uniprot id: G1QLR5
names: Similarity
messages: Belongs to the FBXO45/Fsn family.

61853:SH3GL3
gene id: 61853:SH3GL3
uniprot id: G1RIU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

61853:SLC25A24
gene id: 61853:SLC25A24
uniprot id: G1QLM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

61853:AIPL1
gene id: 61853:AIPL1
uniprot id: A0A2I3H9K7
uniprot id: A0A2I3HVT5
uniprot id: G1RD46
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with NUB1.
messages: May be important in protein trafficking and/or protein folding and stabilization.
messages: Nucleus

61853:TATDN2
gene id: 61853:TATDN2
uniprot id: G1QWQ4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

61853:TSN
gene id: 61853:TSN
uniprot id: A0A2I3G1Z1
uniprot id: A0A2I3H750
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

61853:ARL14
gene id: 61853:ARL14
uniprot id: A0A2I3HBL2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61853:TMBIM4
gene id: 61853:TMBIM4
uniprot id: G1QSF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

61853:CLIC5
gene id: 61853:CLIC5
uniprot id: A0A2I3G7Q1
uniprot id: G1QTT1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61853:NKIRAS1
gene id: 61853:NKIRAS1
uniprot id: A0A2I3H2V3
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

61853:ZBED9
gene id: 61853:ZBED9
uniprot id: G1QX86
names: Subcellular Location Annotation
messages: Nucleus

61853:ENO1
gene id: 61853:ENO1
uniprot id: G1RDB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

61853:NXPE3
gene id: 61853:NXPE3
uniprot id: A0A2I3H9Q7
names: Similarity
messages: Belongs to the NXPE family.

61853:DPF2
gene id: 61853:DPF2
uniprot id: A0A2I3G1Z5
names: Similarity
messages: Belongs to the requiem/DPF family.

61853:GFRA1
gene id: 61853:GFRA1
uniprot id: A0A2I3HH16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

61853:PCMT1
gene id: 61853:PCMT1
uniprot id: A0A2I3G7N0
uniprot id: A0A2I3H3H4
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61853:CPNE3
gene id: 61853:CPNE3
uniprot id: G1QME0
names: Similarity
messages: Belongs to the copine family.

61853:SLC45A2
gene id: 61853:SLC45A2
uniprot id: G1RVV2
names: Subcellular Location Annotation
messages: Membrane

61853:IL33
gene id: 61853:IL33
uniprot id: G1RD14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

61853:HTR1E
gene id: 61853:HTR1E
uniprot id: G1RQZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:TAP1
gene id: 61853:TAP1
uniprot id: G1R4V2
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

61853:TAS2R13
gene id: 61853:TAS2R13
uniprot id: G1QT86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61853:TMEM244
gene id: 61853:TMEM244
uniprot id: G1RVS2
names: Subcellular Location Annotation
messages: Membrane

61853:ALG14
gene id: 61853:ALG14
uniprot id: G1RK94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

61853:ALDH8A1
gene id: 61853:ALDH8A1
uniprot id: A0A2I3H2V2
uniprot id: G1RXB8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61853:CENPK
gene id: 61853:CENPK
uniprot id: A0A2I3GUC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

61853:GADL1
gene id: 61853:GADL1
uniprot id: G1QVT3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61853:OLFML2A
gene id: 61853:OLFML2A
uniprot id: A0A2I3H4S1
uniprot id: G1S661
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:HEATR1
gene id: 61853:HEATR1
uniprot id: G1QTJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

61853:CADM2
gene id: 61853:CADM2
uniprot id: A0A2I3GAN6
uniprot id: A0A2I3HSB2
names: Similarity
messages: Belongs to the nectin family.

61853:MRPS16
gene id: 61853:MRPS16
uniprot id: G1S3N8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

61853:RFTN2
gene id: 61853:RFTN2
uniprot id: G1R5B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

61853:HSPB8
gene id: 61853:HSPB8
uniprot id: G1QH72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

61853:SERPINB5
gene id: 61853:SERPINB5
uniprot id: A0A2I3GI79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

61853:LYVE1
gene id: 61853:LYVE1
uniprot id: G1S773
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PUF60
gene id: 61853:PUF60
uniprot id: A0A2I3HMJ8
uniprot id: A0A2I3HPG1
uniprot id: G1QPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM half pint family.
messages: Nucleus

61853:SLC6A16
gene id: 61853:SLC6A16
uniprot id: G1QYV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61853:IL3
gene id: 61853:IL3
uniprot id: G1RQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-3 family.
messages: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB. Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK.
messages: Secreted

61853:SLITRK3
gene id: 61853:SLITRK3
uniprot id: G1QY30
names: Similarity
messages: Belongs to the SLITRK family.

61853:GC
gene id: 61853:GC
uniprot id: G1R874
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

61853:RND3
gene id: 61853:RND3
uniprot id: G1RIZ5
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

61853:TNFRSF11B
gene id: 61853:TNFRSF11B
uniprot id: G1QYA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MICAL3
gene id: 61853:MICAL3
uniprot id: G1R8P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Nucleus
messages: cytoskeleton

61853:TFAP2D
gene id: 61853:TFAP2D
uniprot id: G1QV54
names: Similarity
messages: Belongs to the AP-2 family.

61853:TMEM242
gene id: 61853:TMEM242
uniprot id: G1RIC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

61853:SMC4
gene id: 61853:SMC4
uniprot id: G1QX56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

61853:TMPO
gene id: 61853:TMPO
uniprot id: A0A2I3FYT4
uniprot id: A0A2I3HVG4
uniprot id: G1R1Z5
names: Similarity
messages: Belongs to the LEM family.

61853:CTSZ
gene id: 61853:CTSZ
uniprot id: G1REJ2
names: Similarity
messages: Belongs to the peptidase C1 family.

61853:IFNA2
gene id: 61853:IFNA2
uniprot id: A0A7R8C3C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:RBM48
gene id: 61853:RBM48
uniprot id: A0A2I3HB57
names: Similarity
messages: Belongs to the RBM48 family.

61853:MCRIP2
gene id: 61853:MCRIP2
uniprot id: G1R9K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCRIP family.
messages: Nucleus
messages: Stress granule

61853:KPNA1
gene id: 61853:KPNA1
uniprot id: G1QHH2
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61853:RSPO3
gene id: 61853:RSPO3
uniprot id: A0A2I3HPC6
names: Similarity
messages: Belongs to the R-spondin family.

61853:PLAG1
gene id: 61853:PLAG1
uniprot id: A0A2I3GXL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

61853:LYRM1
gene id: 61853:LYRM1
uniprot id: G1RNZ4
names: Similarity
messages: Belongs to the complex I LYR family.

61853:PGAP1
gene id: 61853:PGAP1
uniprot id: A0A2I3HF16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

61853:FNIP1
gene id: 61853:FNIP1
uniprot id: A0A2I3GXQ5
uniprot id: A0A2I3HT98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

61853:ARHGDIA
gene id: 61853:ARHGDIA
uniprot id: G1RH56
names: Similarity
messages: Belongs to the Rho GDI family.

61853:PMP2
gene id: 61853:PMP2
uniprot id: G1QPY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

61853:STEAP1
gene id: 61853:STEAP1
uniprot id: G1RYP5
names: Subcellular Location Annotation
messages: Membrane

61853:GALP
gene id: 61853:GALP
uniprot id: G1RIM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
messages: Secreted

61853:GPX7
gene id: 61853:GPX7
uniprot id: G1S8M6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

61853:KDSR
gene id: 61853:KDSR
uniprot id: G1RBM9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:CCND1
gene id: 61853:CCND1
uniprot id: A0A2I3GKV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

61853:NAA38
gene id: 61853:NAA38
uniprot id: A0A2I3GM19
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

61853:SARS1
gene id: 61853:SARS1
uniprot id: A0A2I3GRL2
uniprot id: G1QQH6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

61853:ADAM22
gene id: 61853:ADAM22
uniprot id: A0A2I3GQ97
uniprot id: G1RYK9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:STIM1
gene id: 61853:STIM1
uniprot id: G1S685
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:GRM5
gene id: 61853:GRM5
uniprot id: A0A2I3GJL1
uniprot id: G1S1X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

61853:PMPCA
gene id: 61853:PMPCA
uniprot id: G1RA14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.

61853:LOC100596609
gene id: 61853:LOC100596609
uniprot id: G1RU31
names: Similarity
messages: Belongs to the TEX28 family.

61853:ANP32B
gene id: 61853:ANP32B
uniprot id: G1S4Y8
names: Similarity
messages: Belongs to the ANP32 family.

61853:BABAM2
gene id: 61853:BABAM2
uniprot id: A0A2I3GAP1
uniprot id: G1RZ93
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

61853:TRAPPC3L
gene id: 61853:TRAPPC3L
uniprot id: G1RRP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

61853:KCNJ8
gene id: 61853:KCNJ8
uniprot id: G1QYC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61853:MTFR1
gene id: 61853:MTFR1
uniprot id: G1QV11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

61853:OSTC
gene id: 61853:OSTC
uniprot id: G1RR23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

61853:ARSB
gene id: 61853:ARSB
uniprot id: G1RQM3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61853:SF1
gene id: 61853:SF1
uniprot id: A0A2I3GTB5
uniprot id: A0A2I3HLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

61853:SPTSSA
gene id: 61853:SPTSSA
uniprot id: A0A2I3GSY5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:GREM2
gene id: 61853:GREM2
uniprot id: A0A2I3HLU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:NDUFA3
gene id: 61853:NDUFA3
uniprot id: A0A2I3G418
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

61853:LOC100607067
gene id: 61853:LOC100607067
uniprot id: G1R624
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

61853:LOC100594969
gene id: 61853:LOC100594969
uniprot id: A0A2I3G2L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

61853:ITPR2
gene id: 61853:ITPR2
uniprot id: G1QZX2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

61853:ASB2
gene id: 61853:ASB2
uniprot id: G1S5Y7
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:AMZ1
gene id: 61853:AMZ1
uniprot id: G1RI59
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

61853:NDUFS6
gene id: 61853:NDUFS6
uniprot id: G1RK56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

61853:APOD
gene id: 61853:APOD
uniprot id: G1RAG0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Homodimer.
messages: Secreted

61853:IL1B
gene id: 61853:IL1B
uniprot id: A0A2I3HN27
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

61853:MED17
gene id: 61853:MED17
uniprot id: G1R628
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:RANBP17
gene id: 61853:RANBP17
uniprot id: G1QHG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

61853:DCPS
gene id: 61853:DCPS
uniprot id: A0A2I3G3G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HIT family.
messages: Cytoplasm
messages: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.
messages: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.
messages: Nucleus

61853:GPAM
gene id: 61853:GPAM
uniprot id: A0A2I3H987
uniprot id: G1S0K6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

61853:MAPK13
gene id: 61853:MAPK13
uniprot id: G1RCL2
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

61853:SNX10
gene id: 61853:SNX10
uniprot id: A0A2I3HBN1
uniprot id: G1RY44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

61853:DEFB126
gene id: 61853:DEFB126
uniprot id: G1REI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:ADAMTS20
gene id: 61853:ADAMTS20
uniprot id: A0A2I3GNM7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:PDS5B
gene id: 61853:PDS5B
uniprot id: M3ZBQ8
names: Similarity
messages: Belongs to the PDS5 family.

61853:MTRF1
gene id: 61853:MTRF1
uniprot id: G1QKP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

61853:PDCL2
gene id: 61853:PDCL2
uniprot id: G1RB21
names: Similarity
messages: Belongs to the phosducin family.

61853:MIS18A
gene id: 61853:MIS18A
uniprot id: G1QTZ2
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

61853:LAPTM5
gene id: 61853:LAPTM5
uniprot id: A0A2I3GH06
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

61853:SENP3
gene id: 61853:SENP3
uniprot id: G1REG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

61853:PAX5
gene id: 61853:PAX5
uniprot id: A0A2I3GKR3
uniprot id: A0A2I3GR99
uniprot id: A0A2I3GTQ1
uniprot id: A0A2I3GZV2
uniprot id: A0A2I3HC84
uniprot id: A0A2I3HGH4
uniprot id: A0A2I3HR16
uniprot id: G1QU51
names: Subcellular Location Annotation
messages: Nucleus

61853:TMTC2
gene id: 61853:TMTC2
uniprot id: A0A2I3GTR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

61853:AK1
gene id: 61853:AK1
uniprot id: A0A2I3H2Q6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

61853:EPGN
gene id: 61853:EPGN
uniprot id: A0A2I3HWG5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:EREG
gene id: 61853:EREG
uniprot id: G1R8Z6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PELI3
gene id: 61853:PELI3
uniprot id: A0A2I3HPY9
uniprot id: G1R2J9
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

61853:LOC100597723
gene id: 61853:LOC100597723
uniprot id: G1RKK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:PHB2
gene id: 61853:PHB2
uniprot id: G1QYW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

61853:HADHA
gene id: 61853:HADHA
uniprot id: G1QMB6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

61853:SHCBP1
gene id: 61853:SHCBP1
uniprot id: A0A2I3HYL8
names: Subcellular Location Annotation
messages: spindle

61853:IFNA6
gene id: 61853:IFNA6
uniprot id: A0A7R8C319
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:PHC3
gene id: 61853:PHC3
uniprot id: A0A2I3H7E8
uniprot id: G1QZD8
names: Subcellular Location Annotation
messages: Nucleus

61853:ZSCAN22
gene id: 61853:ZSCAN22
uniprot id: A0A2I3GMM2
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100601682
gene id: 61853:LOC100601682
uniprot id: G1QT77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

61853:MRPS26
gene id: 61853:MRPS26
uniprot id: M3ZCK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Mitochondrion

61853:CAP2
gene id: 61853:CAP2
uniprot id: G1QK71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

61853:SFXN5
gene id: 61853:SFXN5
uniprot id: A0A2I3HN83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

61853:XRCC1
gene id: 61853:XRCC1
uniprot id: G1QLU6
names: Subcellular Location Annotation
messages: Nucleus

61853:UNC5D
gene id: 61853:UNC5D
uniprot id: G1RNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

61853:TBC1D24
gene id: 61853:TBC1D24
uniprot id: G1RE02
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

61853:SCPEP1
gene id: 61853:SCPEP1
uniprot id: G1R9B9
names: Similarity
messages: Belongs to the peptidase S10 family.

61853:USP27X
gene id: 61853:USP27X
uniprot id: A0A2I3GLY5
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61853:ACADL
gene id: 61853:ACADL
uniprot id: G1R6D2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

61853:GHRH
gene id: 61853:GHRH
uniprot id: G1R342
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

61853:GNAI1
gene id: 61853:GNAI1
uniprot id: G1REQ5
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61853:LITAF
gene id: 61853:LITAF
uniprot id: A0A2I3H1A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

61853:LOC100590538
gene id: 61853:LOC100590538
uniprot id: G1S9F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61853:NDUFV2
gene id: 61853:NDUFV2
uniprot id: G1R5J3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

61853:HMX3
gene id: 61853:HMX3
uniprot id: A0A2I3HYL0
names: Subcellular Location Annotation
messages: Nucleus

61853:ARR3
gene id: 61853:ARR3
uniprot id: G1QJ87
names: Function
names: Similarity
messages: Belongs to the arrestin family.
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

61853:LOC100585672
gene id: 61853:LOC100585672
uniprot id: A0A2I3H820
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

61853:ATP5PF
gene id: 61853:ATP5PF
uniprot id: G1QPR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

61853:WASL
gene id: 61853:WASL
uniprot id: G1RNG4
names: Subcellular Location Annotation
messages: Nucleus

61853:PTGDR
gene id: 61853:PTGDR
uniprot id: G1RPH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:LOC100594144
gene id: 61853:LOC100594144
uniprot id: A0A2I3GWH1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:FIP1L1
gene id: 61853:FIP1L1
uniprot id: A0A2I3HRV1
uniprot id: G1R9Y8
uniprot id: M3Z9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

61853:TFEC
gene id: 61853:TFEC
uniprot id: A0A2I3G980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61853:AGTR1
gene id: 61853:AGTR1
uniprot id: A0A2I3HHW9
uniprot id: G1QPQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.

61853:INCENP
gene id: 61853:INCENP
uniprot id: A0A2I3HV30
uniprot id: G1QTB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

61853:RPL10L
gene id: 61853:RPL10L
uniprot id: G1SAZ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

61853:SLC17A3
gene id: 61853:SLC17A3
uniprot id: A0A2I3GTT3
uniprot id: G1QRN3
names: Subcellular Location Annotation
messages: Membrane

61853:CTPS2
gene id: 61853:CTPS2
uniprot id: G1REF4
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

61853:LOC100581059
gene id: 61853:LOC100581059
uniprot id: A0A2I3HBI7
names: Similarity
messages: Belongs to the peptidase A1 family.

61853:GLS2
gene id: 61853:GLS2
uniprot id: G1S6T0
names: Similarity
messages: Belongs to the glutaminase family.

61853:ADAMTS15
gene id: 61853:ADAMTS15
uniprot id: G1R7F0
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:CAPNS1
gene id: 61853:CAPNS1
uniprot id: G1RM58
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates.
messages: Membrane

61853:TSPAN13
gene id: 61853:TSPAN13
uniprot id: G1S3F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:SNAPIN
gene id: 61853:SNAPIN
uniprot id: A0A2I3G7A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAPIN family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.
messages: synaptic vesicle membrane

61853:AGBL5
gene id: 61853:AGBL5
uniprot id: G1QQV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

61853:FUT9
gene id: 61853:FUT9
uniprot id: A0A2I3HAE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

61853:SRD5A3
gene id: 61853:SRD5A3
uniprot id: A0A2I3GNQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

61853:TSC22D1
gene id: 61853:TSC22D1
uniprot id: G1QN91
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61853:RGS9BP
gene id: 61853:RGS9BP
uniprot id: A0A2I3HFA2
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

61853:PTS
gene id: 61853:PTS
uniprot id: A0A2I3GIM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

61853:FAM167B
gene id: 61853:FAM167B
uniprot id: G1QPT1
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

61853:SGK2
gene id: 61853:SGK2
uniprot id: A0A2I3G2D9
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:LOC100599068
gene id: 61853:LOC100599068
uniprot id: G1S9T1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:PLA2G15
gene id: 61853:PLA2G15
uniprot id: G1QZA5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61853:RTEL1
gene id: 61853:RTEL1
uniprot id: A0A2I3GAG0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PPA1
gene id: 61853:PPA1
uniprot id: A0A2I3GMS5
names: Similarity
messages: Belongs to the PPase family.

61853:NBN
gene id: 61853:NBN
uniprot id: A0A2I3GEG0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

61853:ADCK1
gene id: 61853:ADCK1
uniprot id: A0A2I3HXH2
uniprot id: G1S4F5
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

61853:PRICKLE1
gene id: 61853:PRICKLE1
uniprot id: G1S8F2
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

61853:CD164
gene id: 61853:CD164
uniprot id: A0A2I3H2B8
uniprot id: A0A2I3HDJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

61853:TMEM116
gene id: 61853:TMEM116
uniprot id: G1QGK6
names: Subcellular Location Annotation
messages: Membrane

61853:AP3M1
gene id: 61853:AP3M1
uniprot id: G1S4J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

61853:SERPINA6
gene id: 61853:SERPINA6
uniprot id: G1S630
names: Similarity
messages: Belongs to the serpin family.

61853:LOC100593539
gene id: 61853:LOC100593539
uniprot id: A0A2I3GQ73
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

61853:LGI1
gene id: 61853:LGI1
uniprot id: G1RQZ5
names: Subcellular Location Annotation
messages: Secreted

61853:H1-5
gene id: 61853:H1-5
uniprot id: G1SAW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61853:TFPI2
gene id: 61853:TFPI2
uniprot id: A0A2I3GRA7
names: Subcellular Location Annotation
messages: Secreted

61853:CGA
gene id: 61853:CGA
uniprot id: A0A0F7RQQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

61853:GRN
gene id: 61853:GRN
uniprot id: G1QZT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

61853:TENT5B
gene id: 61853:TENT5B
uniprot id: G1RE21
names: Similarity
messages: Belongs to the TENT family.

61853:TNN
gene id: 61853:TNN
uniprot id: G1RZK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

61853:MPDU1
gene id: 61853:MPDU1
uniprot id: G1REV3
names: Subcellular Location Annotation
messages: Membrane

61853:RBM22
gene id: 61853:RBM22
uniprot id: G1RHG3
names: Similarity
messages: Belongs to the SLT11 family.

61853:GMPR
gene id: 61853:GMPR
uniprot id: G1QJZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

61853:HSPB3
gene id: 61853:HSPB3
uniprot id: G1SB43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

61853:LIF
gene id: 61853:LIF
uniprot id: G1QTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

61853:TLE3
gene id: 61853:TLE3
uniprot id: A0A2I3GKB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

61853:BDNF
gene id: 61853:BDNF
uniprot id: G1S855
uniprot id: G1S858
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NGF-beta family.
messages: During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
messages: Monomers and homodimers. Binds to NTRK2/TRKB.
messages: Secreted

61853:TEK
gene id: 61853:TEK
uniprot id: A0A2I3GP71
uniprot id: G1S2P7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SLC25A35
gene id: 61853:SLC25A35
uniprot id: G1RFY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:ADTRP
gene id: 61853:ADTRP
uniprot id: A0A2I3GUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

61853:ZNF768
gene id: 61853:ZNF768
uniprot id: G1S152
names: Subcellular Location Annotation
messages: Nucleus

61853:RAB39B
gene id: 61853:RAB39B
uniprot id: G1RWL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

61853:KCNB2
gene id: 61853:KCNB2
uniprot id: G1QKQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

61853:FADD
gene id: 61853:FADD
uniprot id: G1RHN0
names: Function
messages: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

61853:CDH6
gene id: 61853:CDH6
uniprot id: G1RUL4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:HTR2C
gene id: 61853:HTR2C
uniprot id: A0A2I3GU28
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

61853:PPP1CA
gene id: 61853:PPP1CA
uniprot id: G1R3I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

61853:SMU1
gene id: 61853:SMU1
uniprot id: G1QZJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

61853:GNA14
gene id: 61853:GNA14
uniprot id: G1QR95
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

61853:YARS1
gene id: 61853:YARS1
uniprot id: A0A2I3HNX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Nucleus

61853:FAM118B
gene id: 61853:FAM118B
uniprot id: G1R7B4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

61853:CDC26
gene id: 61853:CDC26
uniprot id: G1S3V0
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

61853:XK
gene id: 61853:XK
uniprot id: G1QJI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61853:SAP30L
gene id: 61853:SAP30L
uniprot id: G1S3M0
names: Similarity
messages: Belongs to the SAP30 family.

61853:AQP6
gene id: 61853:AQP6
uniprot id: A0A2I3HJD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61853:FZD4
gene id: 61853:FZD4
uniprot id: A0A2I3GWH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

61853:LOC100603380
gene id: 61853:LOC100603380
uniprot id: G1RQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Endoplasmic reticulum

61853:NEDD8
gene id: 61853:NEDD8
uniprot id: A0A2I3G605
names: Similarity
messages: Belongs to the ubiquitin family.

61853:USE1
gene id: 61853:USE1
uniprot id: G1R106
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:WEE1
gene id: 61853:WEE1
uniprot id: A0A2I3HLW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

61853:KCNK16
gene id: 61853:KCNK16
uniprot id: A0A2I3HQ07
uniprot id: A0A2I3HWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61853:OGDH
gene id: 61853:OGDH
uniprot id: A0A2I3GT55
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

61853:FSHR
gene id: 61853:FSHR
uniprot id: A0A2I3HAG1
uniprot id: G1RC06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

61853:AQP11
gene id: 61853:AQP11
uniprot id: G1S435
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

61853:CLEC12A
gene id: 61853:CLEC12A
uniprot id: A0A2I3GYK5
uniprot id: A0A2I3HAZ6
uniprot id: G1QS00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:OLFM3
gene id: 61853:OLFM3
uniprot id: A0A2I3G6B1
uniprot id: G1RMV4
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61853:GFRA3
gene id: 61853:GFRA3
uniprot id: G1RC71
names: Similarity
messages: Belongs to the GDNFR family.

61853:CXCR5
gene id: 61853:CXCR5
uniprot id: A0A2I3GYG2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:PDHB
gene id: 61853:PDHB
uniprot id: G1R6U9
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

61853:TAGLN
gene id: 61853:TAGLN
uniprot id: G1R6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

61853:ANK2
gene id: 61853:ANK2
uniprot id: A0A2I3GRC7
uniprot id: A0A2I3HI48
uniprot id: G1S2U2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61853:REM2
gene id: 61853:REM2
uniprot id: G1RXK5
names: Subcellular Location Annotation
messages: Cell membrane

61853:CASS4
gene id: 61853:CASS4
uniprot id: A0A2I3HVS9
uniprot id: G1R5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61853:NOL10
gene id: 61853:NOL10
uniprot id: A0A2I3I044
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

61853:NKX2-2
gene id: 61853:NKX2-2
uniprot id: G1RG95
names: Subcellular Location Annotation
messages: Nucleus

61853:ADAM23
gene id: 61853:ADAM23
uniprot id: A0A2I3GIB3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:ENPP6
gene id: 61853:ENPP6
uniprot id: A0A2I3G8S3
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

61853:NFIA
gene id: 61853:NFIA
uniprot id: G1RXR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

61853:SCIN
gene id: 61853:SCIN
uniprot id: G1S2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

61853:EXOSC1
gene id: 61853:EXOSC1
uniprot id: G1RUD6
names: Subcellular Location Annotation
messages: Cytoplasm

61853:FAM124B
gene id: 61853:FAM124B
uniprot id: G1RF52
names: Similarity
messages: Belongs to the FAM124 family.

61853:DNMBP
gene id: 61853:DNMBP
uniprot id: A0A2I3HTE0
names: Subcellular Location Annotation
messages: Cell junction
messages: Golgi stack
messages: Synapse
messages: cytoskeleton

61853:SLC50A1
gene id: 61853:SLC50A1
uniprot id: A0A2I3GEF2
uniprot id: A0A2I3GUN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Cell membrane
messages: Mediates sugar transport across membranes.
messages: Membrane

61853:PRICKLE2
gene id: 61853:PRICKLE2
uniprot id: G1RMD6
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

61853:PGM1
gene id: 61853:PGM1
uniprot id: G1RYM2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

61853:LOC100601301
gene id: 61853:LOC100601301
uniprot id: A0A2I3GDY1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

61853:MFSD4B
gene id: 61853:MFSD4B
uniprot id: A0A2I3GW71
names: Subcellular Location Annotation
messages: Membrane

61853:RXFP1
gene id: 61853:RXFP1
uniprot id: G1R3I9
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:CAPN14
gene id: 61853:CAPN14
uniprot id: G1S025
names: Similarity
messages: Belongs to the peptidase C2 family.

61853:NELL2
gene id: 61853:NELL2
uniprot id: A0A2I3HW16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:RPL7A
gene id: 61853:RPL7A
uniprot id: G1RRJ8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

61853:DCLRE1B
gene id: 61853:DCLRE1B
uniprot id: A0A2I3HII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

61853:S100A8
gene id: 61853:S100A8
uniprot id: A0A2I3HUD2
names: Similarity
messages: Belongs to the S-100 family.

61853:KCNK5
gene id: 61853:KCNK5
uniprot id: G1RKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61853:VAMP7
gene id: 61853:VAMP7
uniprot id: G1RWQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61853:MRPL11
gene id: 61853:MRPL11
uniprot id: A0A2I3GW90
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

61853:KCNH8
gene id: 61853:KCNH8
uniprot id: A0A2I3GWX5
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

61853:UBA6
gene id: 61853:UBA6
uniprot id: G1RD44
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

61853:ATG101
gene id: 61853:ATG101
uniprot id: G1S7S7
names: Similarity
messages: Belongs to the ATG101 family.

61853:GBX2
gene id: 61853:GBX2
uniprot id: A0A2I3GDG2
uniprot id: G1RI92
names: Subcellular Location Annotation
messages: Nucleus

61853:ACTA2
gene id: 61853:ACTA2
uniprot id: A0A2I3GZD3
names: Similarity
messages: Belongs to the actin family.

61853:DCAF1
gene id: 61853:DCAF1
uniprot id: A0A2I3GCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

61853:JPT1
gene id: 61853:JPT1
uniprot id: A0A2I3G1Y4
uniprot id: A0A2I3HLV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

61853:CFH
gene id: 61853:CFH
uniprot id: A0A2I3H3C6
uniprot id: G1S8U4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CA8
gene id: 61853:CA8
uniprot id: G1QN06
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

61853:CRYAB
gene id: 61853:CRYAB
uniprot id: A0A2I3GIW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

61853:KIF18A
gene id: 61853:KIF18A
uniprot id: G1S865
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:ARFGEF1
gene id: 61853:ARFGEF1
uniprot id: G1RJN8
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

61853:RPL36AL
gene id: 61853:RPL36AL
uniprot id: G1SBY5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61853:BBS5
gene id: 61853:BBS5
uniprot id: A0A2I3GGB3
uniprot id: G1QY66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
messages: centriolar satellite
messages: cilium membrane

61853:USB1
gene id: 61853:USB1
uniprot id: G1QSX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

61853:CDH7
gene id: 61853:CDH7
uniprot id: G1RCP4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:RSPH3
gene id: 61853:RSPH3
uniprot id: G1RJE0
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

61853:TMEM199
gene id: 61853:TMEM199
uniprot id: G1QNM2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:ICAM2
gene id: 61853:ICAM2
uniprot id: G1RYL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61853:SNW1
gene id: 61853:SNW1
uniprot id: A0A2I3GCS6
uniprot id: G1S4E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

61853:SUSD3
gene id: 61853:SUSD3
uniprot id: G1S3H3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100582782
gene id: 61853:LOC100582782
uniprot id: A0A2I3GEH6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

61853:EIF2D
gene id: 61853:EIF2D
uniprot id: G1QIW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

61853:TPST1
gene id: 61853:TPST1
uniprot id: A0A2I3H4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

61853:TMEM87A
gene id: 61853:TMEM87A
uniprot id: A0A2I3H4L2
uniprot id: G1QVV2
names: Subcellular Location Annotation
messages: Membrane

61853:TRPM8
gene id: 61853:TRPM8
uniprot id: A0A2I3HAN8
names: Subcellular Location Annotation
messages: Membrane

61853:MAF1
gene id: 61853:MAF1
uniprot id: G1RHQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

61853:IL20
gene id: 61853:IL20
uniprot id: A0A2I3GLA8
uniprot id: G1QJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

61853:PLA2G2E
gene id: 61853:PLA2G2E
uniprot id: G1R8S6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61853:TUB
gene id: 61853:TUB
uniprot id: G1S6X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

61853:MARVELD2
gene id: 61853:MARVELD2
uniprot id: A0A2I3HAC0
uniprot id: G1QW31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

61853:STX6
gene id: 61853:STX6
uniprot id: G1S1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

61853:LOC100596445
gene id: 61853:LOC100596445
uniprot id: G1R451
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse
messages: axon
messages: dendrite

61853:FOXH1
gene id: 61853:FOXH1
uniprot id: G1RIV3
names: Subcellular Location Annotation
messages: Nucleus

61853:TAC1
gene id: 61853:TAC1
uniprot id: A0A2I3G5G5
uniprot id: G1S1Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

61853:ADCK2
gene id: 61853:ADCK2
uniprot id: A0A2I3G7W1
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

61853:ZKSCAN2
gene id: 61853:ZKSCAN2
uniprot id: G1RLZ9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61853:ALCAM
gene id: 61853:ALCAM
uniprot id: A0A2I3HQA2
names: Subcellular Location Annotation
messages: Cell membrane
messages: axon
messages: dendrite

61853:PGK1
gene id: 61853:PGK1
uniprot id: G1QNC5
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

61853:PTK6
gene id: 61853:PTK6
uniprot id: A0A2I3GG43
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61853:ACTL8
gene id: 61853:ACTL8
uniprot id: G1R8F6
names: Similarity
messages: Belongs to the actin family.

61853:VSTM5
gene id: 61853:VSTM5
uniprot id: G1R631
names: Subcellular Location Annotation
messages: Membrane

61853:WNT5B
gene id: 61853:WNT5B
uniprot id: G1QQI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:CDH19
gene id: 61853:CDH19
uniprot id: A0A2I3G1F4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:ACSS2
gene id: 61853:ACSS2
uniprot id: A0A2I3GS90
uniprot id: A0A2I3H084
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61853:ATP6V0A4
gene id: 61853:ATP6V0A4
uniprot id: G1RUK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

61853:GMNN
gene id: 61853:GMNN
uniprot id: A0A2I3HRC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

61853:BROX
gene id: 61853:BROX
uniprot id: M3Z9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

61853:NKX2-3
gene id: 61853:NKX2-3
uniprot id: A0A2I3HMF5
names: Subcellular Location Annotation
messages: Nucleus

61853:SMARCAL1
gene id: 61853:SMARCAL1
uniprot id: G1R6P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

61853:BRINP3
gene id: 61853:BRINP3
uniprot id: G1S8S9
names: Similarity
messages: Belongs to the BRINP family.

61853:PDGFD
gene id: 61853:PDGFD
uniprot id: A0A2I3FTG5
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LIN7C
gene id: 61853:LIN7C
uniprot id: A0A2I3GMY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

61853:DSG3
gene id: 61853:DSG3
uniprot id: G1R3V6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

61853:KATNAL2
gene id: 61853:KATNAL2
uniprot id: A0A2I3G6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.
messages: Cytoplasm
messages: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
messages: cytoskeleton
messages: spindle
messages: spindle pole

61853:CAMK2D
gene id: 61853:CAMK2D
uniprot id: A0A2I3GBU5
uniprot id: A0A2I3H8G5
uniprot id: G1S2H9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

61853:TRIM32
gene id: 61853:TRIM32
uniprot id: A0A2I3GW37
names: Similarity
messages: Belongs to the TRIM/RBCC family.

61853:PTPN2
gene id: 61853:PTPN2
uniprot id: A0A2I3GGZ2
uniprot id: A0A2I3HME3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

61853:CDCA7L
gene id: 61853:CDCA7L
uniprot id: A0A2I3H1F4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:EMP3
gene id: 61853:EMP3
uniprot id: G1QWG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

61853:USP45
gene id: 61853:USP45
uniprot id: G1RU01
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61853:HCAR2
gene id: 61853:HCAR2
uniprot id: A0A4Y1JWQ6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:CEP76
gene id: 61853:CEP76
uniprot id: G1RCT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

61853:MSRA
gene id: 61853:MSRA
uniprot id: A0A2I3GNB7
uniprot id: A0A2I3H0R5
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

61853:POLR3K
gene id: 61853:POLR3K
uniprot id: G1R900
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

61853:SEC63
gene id: 61853:SEC63
uniprot id: G1RTB2
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100600134
gene id: 61853:LOC100600134
uniprot id: G1RK06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:PDLIM3
gene id: 61853:PDLIM3
uniprot id: A0A2I3GZI6
uniprot id: G1RKG0
names: Subcellular Location Annotation
messages: Z line

61853:SMPX
gene id: 61853:SMPX
uniprot id: G1RFV4
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

61853:CDK2AP1
gene id: 61853:CDK2AP1
uniprot id: A0A2I3G1N6
uniprot id: G1QLD4
names: Similarity
messages: Belongs to the CDK2AP family.

61853:VPS33A
gene id: 61853:VPS33A
uniprot id: G1QLL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

61853:SLC18B1
gene id: 61853:SLC18B1
uniprot id: G1RWY7
names: Subcellular Location Annotation
messages: Membrane

61853:ZZZ3
gene id: 61853:ZZZ3
uniprot id: A0A2I3H6P2
uniprot id: G1REY9
names: Subcellular Location Annotation
messages: Nucleus

61853:TMSB4X
gene id: 61853:TMSB4X
uniprot id: A0A2I3G9U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61853:TENT5A
gene id: 61853:TENT5A
uniprot id: G1RPH5
names: Similarity
messages: Belongs to the TENT family.

61853:POLR2I
gene id: 61853:POLR2I
uniprot id: G1RLW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

61853:BTG2
gene id: 61853:BTG2
uniprot id: A0A2I3FTC7
names: Similarity
messages: Belongs to the BTG family.

61853:DPYSL5
gene id: 61853:DPYSL5
uniprot id: G1QQ70
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

61853:LOC100587536
gene id: 61853:LOC100587536
uniprot id: A0A2I3G1L3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:ABT1
gene id: 61853:ABT1
uniprot id: A0A2I3HBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

61853:NUDC
gene id: 61853:NUDC
uniprot id: G1RE19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

61853:THEMIS
gene id: 61853:THEMIS
uniprot id: G1RVG2
names: Similarity
messages: Belongs to the themis family.

61853:FAM126A
gene id: 61853:FAM126A
uniprot id: G1S4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

61853:PRKCI
gene id: 61853:PRKCI
uniprot id: M3Z9F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

61853:SH3BGRL
gene id: 61853:SH3BGRL
uniprot id: G1QQ20
names: Similarity
messages: Belongs to the SH3BGR family.

61853:TDRD9
gene id: 61853:TDRD9
uniprot id: G1S2J9
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

61853:KBTBD8
gene id: 61853:KBTBD8
uniprot id: G1R7K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

61853:ATP23
gene id: 61853:ATP23
uniprot id: G1S5Q6
names: Similarity
messages: Belongs to the peptidase M76 family.

61853:ZKSCAN3
gene id: 61853:ZKSCAN3
uniprot id: G1QX65
names: Subcellular Location Annotation
messages: Nucleus

61853:ETFA
gene id: 61853:ETFA
uniprot id: G1R9T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

61853:GJA8
gene id: 61853:GJA8
uniprot id: G1QHA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:PHYH
gene id: 61853:PHYH
uniprot id: G1RNQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

61853:GATM
gene id: 61853:GATM
uniprot id: A0A2I3G013
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.
messages: Homodimer.
messages: Mitochondrion inner membrane

61853:ANO6
gene id: 61853:ANO6
uniprot id: A0A2I3HGP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

61853:LOC100592919
gene id: 61853:LOC100592919
uniprot id: G1S988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ETNPPL
gene id: 61853:ETNPPL
uniprot id: G1RR18
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

61853:OGFOD1
gene id: 61853:OGFOD1
uniprot id: A0A2I3GZI4
names: Similarity
messages: Belongs to the TPA1 family.

61853:NEUROD6
gene id: 61853:NEUROD6
uniprot id: G1RZ06
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

61853:VAMP8
gene id: 61853:VAMP8
uniprot id: G1QN71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61853:ATP1B2
gene id: 61853:ATP1B2
uniprot id: G1RF36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

61853:PTDSS1
gene id: 61853:PTDSS1
uniprot id: G1QTX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:RPL22L1
gene id: 61853:RPL22L1
uniprot id: G1QZL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

61853:LOC100605953
gene id: 61853:LOC100605953
uniprot id: A0A2I3H3Q3
names: Similarity
messages: Belongs to the NipSnap family.

61853:DGKG
gene id: 61853:DGKG
uniprot id: G1R446
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61853:DOLK
gene id: 61853:DOLK
uniprot id: G1SBG5
names: Similarity
messages: Belongs to the polyprenol kinase family.

61853:LOC100586163
gene id: 61853:LOC100586163
uniprot id: G1QUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

61853:LOC100602615
gene id: 61853:LOC100602615
uniprot id: A0A2I3HSQ6
names: Similarity
messages: Belongs to the cytochrome b5 family.

61853:PAPSS1
gene id: 61853:PAPSS1
uniprot id: A0A2I3HQ83
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

61853:SNRPG
gene id: 61853:SNRPG
uniprot id: G1RGQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

61853:G6PC3
gene id: 61853:G6PC3
uniprot id: G1R0M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

61853:MRPL46
gene id: 61853:MRPL46
uniprot id: G1RKZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

61853:HSPA14
gene id: 61853:HSPA14
uniprot id: G1RNC1
uniprot id: G1RNC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

61853:ECRG4
gene id: 61853:ECRG4
uniprot id: G1RIF2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

61853:ATP6V0D2
gene id: 61853:ATP6V0D2
uniprot id: G1QLE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61853:NAAA
gene id: 61853:NAAA
uniprot id: G1R9A9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

61853:COPS4
gene id: 61853:COPS4
uniprot id: A0A2I3HLV8
uniprot id: G1RCM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

61853:CD47
gene id: 61853:CD47
uniprot id: A0A2I3GCJ8
uniprot id: G1QTZ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:LOC100587683
gene id: 61853:LOC100587683
uniprot id: A0A2I3HHC8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

61853:RABGGTB
gene id: 61853:RABGGTB
uniprot id: G1REP9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

61853:MMP20
gene id: 61853:MMP20
uniprot id: G1R6B1
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:PLD1
gene id: 61853:PLD1
uniprot id: A0A2I3HGH2
names: Similarity
messages: Belongs to the phospholipase D family.

61853:PHACTR1
gene id: 61853:PHACTR1
uniprot id: G1QIZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

61853:EI24
gene id: 61853:EI24
uniprot id: A0A2I3H4N6
uniprot id: A0A2I3H752
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

61853:ADPRH
gene id: 61853:ADPRH
uniprot id: G1QYJ4
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

61853:DEUP1
gene id: 61853:DEUP1
uniprot id: G1R617
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

61853:LEF1
gene id: 61853:LEF1
uniprot id: A0A2I3GUR9
uniprot id: A0A2I3H062
uniprot id: A0A2I3HVW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

61853:IFNG
gene id: 61853:IFNG
uniprot id: G1QTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

61853:YIPF4
gene id: 61853:YIPF4
uniprot id: A0A2I3GRI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

61853:HIGD1C
gene id: 61853:HIGD1C
uniprot id: G1S7W4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

61853:CRIPT
gene id: 61853:CRIPT
uniprot id: G1S4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

61853:UCHL3
gene id: 61853:UCHL3
uniprot id: A0A2I3GN22
names: Similarity
messages: Belongs to the peptidase C12 family.

61853:HK2
gene id: 61853:HK2
uniprot id: G1QK52
names: Similarity
messages: Belongs to the hexokinase family.

61853:CXCL5
gene id: 61853:CXCL5
uniprot id: G1R8Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:LOC100584083
gene id: 61853:LOC100584083
uniprot id: A0A2I3GMX3
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61853:FBLN2
gene id: 61853:FBLN2
uniprot id: G1QYF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:ARPP19
gene id: 61853:ARPP19
uniprot id: G1R444
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

61853:KRT73
gene id: 61853:KRT73
uniprot id: G1S7P9
names: Similarity
messages: Belongs to the intermediate filament family.

61853:GJA1
gene id: 61853:GJA1
uniprot id: A0A654IE97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:HIF3A
gene id: 61853:HIF3A
uniprot id: A0A2I3HJJ6
uniprot id: G1QQE6
names: Subcellular Location Annotation
messages: Nucleus speckle

61853:CA12
gene id: 61853:CA12
uniprot id: A0A2I3GGB1
uniprot id: A0A2I3GKK7
uniprot id: G1RNT6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61853:NT5E
gene id: 61853:NT5E
uniprot id: G1RQP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

61853:GPN1
gene id: 61853:GPN1
uniprot id: G1QV73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

61853:LOC100583507
gene id: 61853:LOC100583507
uniprot id: G1R963
names: Similarity
messages: Belongs to the globin family.

61853:MME
gene id: 61853:MME
uniprot id: G1QUC3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

61853:CFB
gene id: 61853:CFB
uniprot id: M3Z963
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:CNOT1
gene id: 61853:CNOT1
uniprot id: G1QUG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

61853:IL17B
gene id: 61853:IL17B
uniprot id: A0A2I3G8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61853:S100A9
gene id: 61853:S100A9
uniprot id: G1RHE3
names: Similarity
messages: Belongs to the S-100 family.

61853:RNASE7
gene id: 61853:RNASE7
uniprot id: G1RVR6
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61853:ARF1
gene id: 61853:ARF1
uniprot id: G1RVH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61853:EPB42
gene id: 61853:EPB42
uniprot id: A0A2I3GFA9
uniprot id: G1QY95
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

61853:FAM219B
gene id: 61853:FAM219B
uniprot id: G1RXA4
names: Similarity
messages: Belongs to the FAM219 family.

61853:ICAM4
gene id: 61853:ICAM4
uniprot id: A0A2I3GGM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61853:IRF9
gene id: 61853:IRF9
uniprot id: G1RZ88
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:LSM6
gene id: 61853:LSM6
uniprot id: G1R0N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

61853:TOP3A
gene id: 61853:TOP3A
uniprot id: A0A2I3GKX0
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

61853:HTR5A
gene id: 61853:HTR5A
uniprot id: A0A2I3GB88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PPIL1
gene id: 61853:PPIL1
uniprot id: A0A2I3GBL8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61853:KMO
gene id: 61853:KMO
uniprot id: A0A2I3FZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

61853:KCNJ11
gene id: 61853:KCNJ11
uniprot id: A0A2I3HLF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.
messages: Membrane

61853:BEX1
gene id: 61853:BEX1
uniprot id: G1SA99
names: Similarity
messages: Belongs to the BEX family.

61853:TMEM115
gene id: 61853:TMEM115
uniprot id: A0A2I3HS67
names: Subcellular Location Annotation
messages: Membrane

61853:CCNB2
gene id: 61853:CCNB2
uniprot id: G1RLG5
names: Similarity
messages: Belongs to the cyclin family.

61853:SLC18A1
gene id: 61853:SLC18A1
uniprot id: A0A2I3G8S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Vesicular transporter family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

61853:NPTX1
gene id: 61853:NPTX1
uniprot id: G1S0T0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:ATL3
gene id: 61853:ATL3
uniprot id: A0A2I3HXG9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61853:LOC100591157
gene id: 61853:LOC100591157
uniprot id: G1R9H0
names: Similarity
messages: Belongs to the GAGE family.

61853:SLC20A1
gene id: 61853:SLC20A1
uniprot id: G1QMJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

61853:YAF2
gene id: 61853:YAF2
uniprot id: G1S8G1
uniprot id: G1S8G2
names: Subcellular Location Annotation
messages: Nucleus

61853:STX17
gene id: 61853:STX17
uniprot id: A0A2I3HYN6
names: Similarity
messages: Belongs to the syntaxin family.

61853:BMP5
gene id: 61853:BMP5
uniprot id: G1QSM4
names: Similarity
messages: Belongs to the TGF-beta family.

61853:GALNT16
gene id: 61853:GALNT16
uniprot id: G1QLF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:SLC1A7
gene id: 61853:SLC1A7
uniprot id: A0A2I3H9H4
uniprot id: A0A2I3HQ96
uniprot id: G1S8L7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:CLDN1
gene id: 61853:CLDN1
uniprot id: G1R4T2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:DMRT2
gene id: 61853:DMRT2
uniprot id: G1RB53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61853:LPCAT3
gene id: 61853:LPCAT3
uniprot id: G1QZ09
names: Subcellular Location Annotation
messages: Membrane

61853:GPC5
gene id: 61853:GPC5
uniprot id: G1S3B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

61853:PIGO
gene id: 61853:PIGO
uniprot id: A0A2I3GAK0
uniprot id: G1QXF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:LOC100582227
gene id: 61853:LOC100582227
uniprot id: A0A2I3GD22
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61853:SST
gene id: 61853:SST
uniprot id: G1R4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

61853:NIFK
gene id: 61853:NIFK
uniprot id: G1QKG8
names: Subcellular Location Annotation
messages: nucleolus

61853:INHA
gene id: 61853:INHA
uniprot id: G1REI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
messages: Secreted

61853:DCP1A
gene id: 61853:DCP1A
uniprot id: G1R6I4
names: Similarity
messages: Belongs to the DCP1 family.

61853:UVSSA
gene id: 61853:UVSSA
uniprot id: G1QK36
names: Similarity
messages: Belongs to the UVSSA family.

61853:MTERF1
gene id: 61853:MTERF1
uniprot id: A0A2I3HH87
names: Similarity
messages: Belongs to the mTERF family.

61853:MC2R
gene id: 61853:MC2R
uniprot id: A0A2I3GEJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
messages: Membrane
messages: Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

61853:ERLIN1
gene id: 61853:ERLIN1
uniprot id: G1RXE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

61853:RPS27L
gene id: 61853:RPS27L
uniprot id: A0A2I3FPV2
uniprot id: A0A2I3GXM5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61853:CASKIN2
gene id: 61853:CASKIN2
uniprot id: G1QK01
names: Subcellular Location Annotation
messages: Cytoplasm

61853:SYNPR
gene id: 61853:SYNPR
uniprot id: A0A2I3H8L4
uniprot id: G1RM18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61853:ZNF174
gene id: 61853:ZNF174
uniprot id: A0A2I3G3X8
uniprot id: A0A2I3HF44
names: Subcellular Location Annotation
messages: Nucleus

61853:PSMB5
gene id: 61853:PSMB5
uniprot id: A0A2I3HBS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:DYNC1H1
gene id: 61853:DYNC1H1
uniprot id: G1S1B6
names: Similarity
messages: Belongs to the dynein heavy chain family.

61853:SS18L2
gene id: 61853:SS18L2
uniprot id: G1R1K2
names: Similarity
messages: Belongs to the SS18 family.

61853:EXT2
gene id: 61853:EXT2
uniprot id: A0A2I3HBP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:CBR1
gene id: 61853:CBR1
uniprot id: G1QWG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

61853:SELENOS
gene id: 61853:SELENOS
uniprot id: G1QHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
messages: Membrane

61853:CDNF
gene id: 61853:CDNF
uniprot id: G1RND0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

61853:FABP6
gene id: 61853:FABP6
uniprot id: G1QWC9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:FDFT1
gene id: 61853:FDFT1
uniprot id: A0A2I3HU46
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

61853:GABRA6
gene id: 61853:GABRA6
uniprot id: G1QX18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:CLCC1
gene id: 61853:CLCC1
uniprot id: G1QNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel MCLC family.
messages: Membrane
messages: Nucleus membrane

61853:NIPSNAP3A
gene id: 61853:NIPSNAP3A
uniprot id: A0A2I3GVK1
names: Similarity
messages: Belongs to the NipSnap family.

61853:UTP11
gene id: 61853:UTP11
uniprot id: A0A2I3HVL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

61853:CENPC
gene id: 61853:CENPC
uniprot id: G1RCV4
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

61853:ADGRL4
gene id: 61853:ADGRL4
uniprot id: G1RFG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:CCKAR
gene id: 61853:CCKAR
uniprot id: G1S4V8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

61853:DICER1
gene id: 61853:DICER1
uniprot id: G1S694
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

61853:TRDN
gene id: 61853:TRDN
uniprot id: A0A2I3FSH3
uniprot id: A0A2I3H785
uniprot id: G1RUE8
names: Subcellular Location Annotation
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61853:FBXL5
gene id: 61853:FBXL5
uniprot id: G1S2Z0
names: Subcellular Location Annotation
messages: perinuclear region

61853:PITHD1
gene id: 61853:PITHD1
uniprot id: G1RBE3
names: Similarity
messages: Belongs to the PITHD1 family.

61853:DHRS9
gene id: 61853:DHRS9
uniprot id: G1QXL3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:HOXD1
gene id: 61853:HOXD1
uniprot id: G1R257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

61853:CCR4
gene id: 61853:CCR4
uniprot id: G1SA82
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:PSENEN
gene id: 61853:PSENEN
uniprot id: A0A2I3H000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

61853:MCU
gene id: 61853:MCU
uniprot id: G1S385
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

61853:MRPS5
gene id: 61853:MRPS5
uniprot id: G1QGH5
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

61853:IL12RB2
gene id: 61853:IL12RB2
uniprot id: A0A2I3GHI5
uniprot id: A0A2I3H044
uniprot id: G1RDE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61853:ASPDH
gene id: 61853:ASPDH
uniprot id: G1R103
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

61853:LOC100587834
gene id: 61853:LOC100587834
uniprot id: G1SBF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:CBFA2T2
gene id: 61853:CBFA2T2
uniprot id: A0A2I3GH88
uniprot id: A0A2I3HX66
names: Similarity
messages: Belongs to the CBFA2T family.

61853:CD3E
gene id: 61853:CD3E
uniprot id: A0A2I3HEF8
names: Subcellular Location Annotation
messages: Membrane

61853:ND2
gene id: 61853:ND2
uniprot id: E7EAE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

61853:MTMR10
gene id: 61853:MTMR10
uniprot id: G1R7I7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61853:LOC100588845
gene id: 61853:LOC100588845
uniprot id: G1S9V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:NPFFR1
gene id: 61853:NPFFR1
uniprot id: G1S1Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

61853:CDCA2
gene id: 61853:CDCA2
uniprot id: G1S283
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC26A3
gene id: 61853:SLC26A3
uniprot id: G1RBF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Chloride/bicarbonate exchanger.
messages: Membrane

61853:UXT
gene id: 61853:UXT
uniprot id: A0A2I3G2N3
names: Similarity
messages: Belongs to the UXT family.

61853:APOA4
gene id: 61853:APOA4
uniprot id: G1R6X2
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

61853:PABPC4
gene id: 61853:PABPC4
uniprot id: A0A2I3GCJ7
uniprot id: G1RMR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

61853:PPEF1
gene id: 61853:PPEF1
uniprot id: A0A2I3FYA1
names: Similarity
messages: Belongs to the PPP phosphatase family.

61853:LOC100591514
gene id: 61853:LOC100591514
uniprot id: A0A2I3HKK9
names: Similarity
messages: Belongs to the PRORSD1 family.

61853:DSC3
gene id: 61853:DSC3
uniprot id: A0A2I3HMK5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61853:ECHS1
gene id: 61853:ECHS1
uniprot id: G1QP93
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

61853:ZSCAN23
gene id: 61853:ZSCAN23
uniprot id: A0A2I3HH08
names: Subcellular Location Annotation
messages: Nucleus

61853:E2F8
gene id: 61853:E2F8
uniprot id: G1S7Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61853:LOC100582668
gene id: 61853:LOC100582668
uniprot id: G1RIN2
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100588656
gene id: 61853:LOC100588656
uniprot id: A0A2I3G9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:NPNT
gene id: 61853:NPNT
uniprot id: A0A2I3GFX8
uniprot id: G1RRN3
uniprot id: M3Z9E0
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TES
gene id: 61853:TES
uniprot id: Q07DY3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).
messages: The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.
messages: focal adhesion

61853:LOC100582253
gene id: 61853:LOC100582253
uniprot id: A0A2I3HBB2
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

61853:PPA2
gene id: 61853:PPA2
uniprot id: G1RS63
names: Similarity
messages: Belongs to the PPase family.

61853:PARPBP
gene id: 61853:PARPBP
uniprot id: G1R3J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

61853:CASC4
gene id: 61853:CASC4
uniprot id: A0A2I3HGM4
uniprot id: G1R0H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

61853:RBBP5
gene id: 61853:RBBP5
uniprot id: A0A2I3G836
names: Subcellular Location Annotation
messages: Nucleus

61853:NFIB
gene id: 61853:NFIB
uniprot id: A0A2I3GME2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

61853:LOC100606612
gene id: 61853:LOC100606612
uniprot id: A0A2I3GP37
names: Similarity
messages: Belongs to the LCE family.

61853:TMED1
gene id: 61853:TMED1
uniprot id: G1RP56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61853:MEGF11
gene id: 61853:MEGF11
uniprot id: G1RQY2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:GCH1
gene id: 61853:GCH1
uniprot id: G1RQH2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

61853:DDIT3
gene id: 61853:DDIT3
uniprot id: G1S665
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

61853:LOC100579706
gene id: 61853:LOC100579706
uniprot id: M3ZAH2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:COLEC12
gene id: 61853:COLEC12
uniprot id: G1R560
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100604897
gene id: 61853:LOC100604897
uniprot id: A0A2I3GIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

61853:LOC100587000
gene id: 61853:LOC100587000
uniprot id: A0A2I3HH82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:LMBR1L
gene id: 61853:LMBR1L
uniprot id: G1S839
names: Similarity
messages: Belongs to the LIMR family.

61853:ALG8
gene id: 61853:ALG8
uniprot id: A0A2I3HB56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:TWSG1
gene id: 61853:TWSG1
uniprot id: G1R5J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

61853:SNRPD2
gene id: 61853:SNRPD2
uniprot id: G1QP64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

61853:ACTR1A
gene id: 61853:ACTR1A
uniprot id: G1RYT8
names: Similarity
messages: Belongs to the actin family.

61853:TTC26
gene id: 61853:TTC26
uniprot id: G1RV49
names: Similarity
messages: Belongs to the IFT56 family.

61853:QTRT1
gene id: 61853:QTRT1
uniprot id: G1RP20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

61853:NRN1L
gene id: 61853:NRN1L
uniprot id: G1QYN5
names: Similarity
messages: Belongs to the neuritin family.

61853:DDRGK1
gene id: 61853:DDRGK1
uniprot id: A0A2I3HZR3
names: Similarity
messages: Belongs to the DDRGK1 family.

61853:SLC25A5
gene id: 61853:SLC25A5
uniprot id: G1RXU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

61853:HABP2
gene id: 61853:HABP2
uniprot id: G1S1G6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:SEPTIN4
gene id: 61853:SEPTIN4
uniprot id: A0A2I3GAN4
uniprot id: A0A2I3HPY7
uniprot id: G1RA55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61853:BTN2A1
gene id: 61853:BTN2A1
uniprot id: G1QSX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

61853:CSNK1A1L
gene id: 61853:CSNK1A1L
uniprot id: G1SAJ6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:WDYHV1
gene id: 61853:WDYHV1
uniprot id: G1QZT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

61853:FMOD
gene id: 61853:FMOD
uniprot id: G1S917
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to type I and type II collagen.
messages: extracellular matrix

61853:PEMT
gene id: 61853:PEMT
uniprot id: G1RTA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

61853:SLC13A2
gene id: 61853:SLC13A2
uniprot id: G1QP88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61853:PIAS1
gene id: 61853:PIAS1
uniprot id: A0A2I3HR02
names: Similarity
messages: Belongs to the PIAS family.

61853:MYADML2
gene id: 61853:MYADML2
uniprot id: A0A2I3FUB6
names: Subcellular Location Annotation
messages: Membrane

61853:XPNPEP1
gene id: 61853:XPNPEP1
uniprot id: A0A2I3H708
names: Similarity
messages: Belongs to the peptidase M24B family.

61853:MFAP5
gene id: 61853:MFAP5
uniprot id: G1QNW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

61853:TNNT2
gene id: 61853:TNNT2
uniprot id: G1S8X4
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

61853:CLASP2
gene id: 61853:CLASP2
uniprot id: A0A2I3HT73
names: Subcellular Location Annotation
messages: kinetochore

61853:POLR1E
gene id: 61853:POLR1E
uniprot id: A0A2I3G1H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

61853:LHCGR
gene id: 61853:LHCGR
uniprot id: G1RBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

61853:UTP14A
gene id: 61853:UTP14A
uniprot id: G1RZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

61853:ANXA13
gene id: 61853:ANXA13
uniprot id: A0A2I3H4Q7
uniprot id: G1QZZ3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61853:CAPN3
gene id: 61853:CAPN3
uniprot id: A0A2I3HW10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C2 family.
messages: Calcium-regulated non-lysosomal thiol-protease.
messages: Cytoplasm
messages: Homodimer.

61853:GRAP2
gene id: 61853:GRAP2
uniprot id: A0A2I3GYL6
names: Similarity
messages: Belongs to the GRB2/sem-5/DRK family.

61853:RASGRP2
gene id: 61853:RASGRP2
uniprot id: G1QZB8
names: Similarity
messages: Belongs to the RASGRP family.

61853:KIF27
gene id: 61853:KIF27
uniprot id: G1QTC6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:ATP8
gene id: 61853:ATP8
uniprot id: D4QAT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

61853:LOC100606472
gene id: 61853:LOC100606472
uniprot id: A0A2I3GKB4
names: Similarity
messages: Belongs to the MHC class II family.

61853:FOXB1
gene id: 61853:FOXB1
uniprot id: G1RLU0
names: Subcellular Location Annotation
messages: Nucleus

61853:HCST
gene id: 61853:HCST
uniprot id: G1RLI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Membrane

61853:INO80D
gene id: 61853:INO80D
uniprot id: A0A2I3G6D8
names: Subcellular Location Annotation
messages: Nucleus

61853:DNAJC27
gene id: 61853:DNAJC27
uniprot id: G1QK63
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

61853:FAM122A
gene id: 61853:FAM122A
uniprot id: A0A2I3G745
names: Similarity
messages: Belongs to the FAM122 family.

61853:INPP5J
gene id: 61853:INPP5J
uniprot id: G1QW39
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

61853:RAD21
gene id: 61853:RAD21
uniprot id: G1QY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

61853:LOC100597620
gene id: 61853:LOC100597620
uniprot id: A0A7R8C309
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:ATP5F1E
gene id: 61853:ATP5F1E
uniprot id: G1SAJ2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

61853:SDR42E1
gene id: 61853:SDR42E1
uniprot id: G1RID6
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61853:CXCL10
gene id: 61853:CXCL10
uniprot id: G1R9F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:LSM8
gene id: 61853:LSM8
uniprot id: G1RM40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

61853:HSPB7
gene id: 61853:HSPB7
uniprot id: G1R7Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Nucleus

61853:ELMO1
gene id: 61853:ELMO1
uniprot id: G1QQ57
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

61853:MPHOSPH8
gene id: 61853:MPHOSPH8
uniprot id: G1QKR0
names: Subcellular Location Annotation
messages: Nucleus

61853:OPALIN
gene id: 61853:OPALIN
uniprot id: A0A2I3GZJ4
uniprot id: G1RSN4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

61853:ASPM
gene id: 61853:ASPM
uniprot id: A0A2I3GN13
names: Subcellular Location Annotation
messages: Nucleus
messages: spindle

61853:WT1
gene id: 61853:WT1
uniprot id: A0A2I3HTM5
uniprot id: G1S896
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

61853:AGO1
gene id: 61853:AGO1
uniprot id: G1RK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the argonaute family.
messages: P-body

61853:RBBP8
gene id: 61853:RBBP8
uniprot id: E5FGF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

61853:KCNK13
gene id: 61853:KCNK13
uniprot id: A0A2I3HMD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61853:SLITRK6
gene id: 61853:SLITRK6
uniprot id: G1S398
names: Similarity
messages: Belongs to the SLITRK family.

61853:APOBEC1
gene id: 61853:APOBEC1
uniprot id: G1QZV0
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

61853:RCAN3
gene id: 61853:RCAN3
uniprot id: G1RCG5
names: Similarity
messages: Belongs to the RCAN family.

61853:IZUMO2
gene id: 61853:IZUMO2
uniprot id: G1R0H4
names: Similarity
messages: Belongs to the Izumo family.

61853:UCP1
gene id: 61853:UCP1
uniprot id: G1QZ98
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

61853:NPAS4
gene id: 61853:NPAS4
uniprot id: G1R2I3
names: Subcellular Location Annotation
messages: Nucleus

61853:DKK1
gene id: 61853:DKK1
uniprot id: G1RMY5
names: Similarity
messages: Belongs to the dickkopf family.

61853:FAM83B
gene id: 61853:FAM83B
uniprot id: G1QSV9
names: Similarity
messages: Belongs to the FAM83 family.

61853:FAM210A
gene id: 61853:FAM210A
uniprot id: G1RDC7
names: Similarity
messages: Belongs to the FAM210 family.

61853:ZSCAN21
gene id: 61853:ZSCAN21
uniprot id: A0A2I3GAQ2
names: Subcellular Location Annotation
messages: Nucleus

61853:TBX19
gene id: 61853:TBX19
uniprot id: G1RY22
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:RNGTT
gene id: 61853:RNGTT
uniprot id: A0A2I3FRX4
uniprot id: G1RRK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

61853:PIK3C2G
gene id: 61853:PIK3C2G
uniprot id: A0A2I3GHE4
uniprot id: G1QWK3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61853:GSTZ1
gene id: 61853:GSTZ1
uniprot id: G1S452
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

61853:API5
gene id: 61853:API5
uniprot id: G1S8H4
names: Similarity
messages: Belongs to the API5 family.

61853:MMP15
gene id: 61853:MMP15
uniprot id: G1QT14
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:CHRDL2
gene id: 61853:CHRDL2
uniprot id: A0A2I3H661
names: Subcellular Location Annotation
messages: Secreted

61853:MS4A10
gene id: 61853:MS4A10
uniprot id: G1RT59
names: Similarity
messages: Belongs to the MS4A family.

61853:NCBP1
gene id: 61853:NCBP1
uniprot id: A0A2I3GLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

61853:PTTG1
gene id: 61853:PTTG1
uniprot id: G1QWP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

61853:SLC35B2
gene id: 61853:SLC35B2
uniprot id: G1QU44
uniprot id: M3ZAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

61853:TAFA2
gene id: 61853:TAFA2
uniprot id: G1S5L6
names: Similarity
messages: Belongs to the TAFA family.

61853:TUBD1
gene id: 61853:TUBD1
uniprot id: A0A2I3GZR1
uniprot id: G1QIU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

61853:LOC100605657
gene id: 61853:LOC100605657
uniprot id: A0A2I3HWQ4
uniprot id: G1S5F1
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:ACOT8
gene id: 61853:ACOT8
uniprot id: A0A2I3GHU4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61853:GNPDA2
gene id: 61853:GNPDA2
uniprot id: G1S682
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

61853:FNIP2
gene id: 61853:FNIP2
uniprot id: G1R3P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

61853:SEC61A2
gene id: 61853:SEC61A2
uniprot id: G1RP04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:MTMR6
gene id: 61853:MTMR6
uniprot id: A0A2I3HPM5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61853:ERGIC2
gene id: 61853:ERGIC2
uniprot id: G1R0W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

61853:NXPH1
gene id: 61853:NXPH1
uniprot id: A0A2I3HT56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

61853:MOG
gene id: 61853:MOG
uniprot id: A0A2I3H556
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Homodimer.
messages: Membrane
messages: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.

61853:VEPH1
gene id: 61853:VEPH1
uniprot id: A0A2I3H471
uniprot id: G1QVH6
names: Similarity
messages: Belongs to the MELT/VEPH family.

61853:CWC25
gene id: 61853:CWC25
uniprot id: G1QIJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

61853:LOC100590137
gene id: 61853:LOC100590137
uniprot id: G1RUC9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61853:PSMB8
gene id: 61853:PSMB8
uniprot id: G1R4S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:VTI1B
gene id: 61853:VTI1B
uniprot id: G1QJ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

61853:CKMT2
gene id: 61853:CKMT2
uniprot id: G1RRK3
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

61853:LOC100593084
gene id: 61853:LOC100593084
uniprot id: A0A2I3H772
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:POPDC2
gene id: 61853:POPDC2
uniprot id: A0A2I3GU86
uniprot id: G1QYP7
names: Similarity
messages: Belongs to the popeye family.

61853:ARHGEF28
gene id: 61853:ARHGEF28
uniprot id: A0A2I3GRU5
uniprot id: A0A2I3HLK0
names: Subcellular Location Annotation
messages: Cytoplasm

61853:CNTF
gene id: 61853:CNTF
uniprot id: A0A2I3FY37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

61853:FABP1
gene id: 61853:FABP1
uniprot id: G1QRN1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
messages: Cytoplasm
messages: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

61853:AMELX
gene id: 61853:AMELX
uniprot id: A0A2I3HHT8
uniprot id: A0A2I3HX96
uniprot id: G1RCS3
names: Similarity
messages: Belongs to the amelogenin family.

61853:BTBD10
gene id: 61853:BTBD10
uniprot id: A0A2I3GJC2
uniprot id: G1S7H9
names: Subcellular Location Annotation
messages: Cytoplasm

61853:RPS26
gene id: 61853:RPS26
uniprot id: M3ZC70
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61853:MFSD14A
gene id: 61853:MFSD14A
uniprot id: A0A2I3GNP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61853:TEKT5
gene id: 61853:TEKT5
uniprot id: G1RGJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61853:ASF1B
gene id: 61853:ASF1B
uniprot id: A0A2I3H660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

61853:NIPAL1
gene id: 61853:NIPAL1
uniprot id: G1S6F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61853:TF
gene id: 61853:TF
uniprot id: A0A0A7RNC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferrin family.
messages: Monomer.
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

61853:SLIT1
gene id: 61853:SLIT1
uniprot id: G1RTQ5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:SS18
gene id: 61853:SS18
uniprot id: A0A2I3G283
names: Similarity
messages: Belongs to the SS18 family.

61853:MMP27
gene id: 61853:MMP27
uniprot id: G1R6B5
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:LOC100587245
gene id: 61853:LOC100587245
uniprot id: A0A2I3HNS8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61853:AMER2
gene id: 61853:AMER2
uniprot id: A0A2I3FTN3
names: Similarity
messages: Belongs to the Amer family.

61853:HSPA9
gene id: 61853:HSPA9
uniprot id: G1RCT8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61853:LOC100605842
gene id: 61853:LOC100605842
uniprot id: G1SBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SERPINA1
gene id: 61853:SERPINA1
uniprot id: G1S644
names: Similarity
messages: Belongs to the serpin family.

61853:VPS33B
gene id: 61853:VPS33B
uniprot id: G1RNY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

61853:MRPS9
gene id: 61853:MRPS9
uniprot id: A0A2I3FZS6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

61853:EDEM3
gene id: 61853:EDEM3
uniprot id: A0A2I3GBI7
uniprot id: G1S8R1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61853:NDUFAF4
gene id: 61853:NDUFAF4
uniprot id: G1RT50
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

61853:IL18
gene id: 61853:IL18
uniprot id: A0A2I3H411
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted

61853:HBM
gene id: 61853:HBM
uniprot id: G1R944
names: Similarity
messages: Belongs to the globin family.

61853:PLA1A
gene id: 61853:PLA1A
uniprot id: A0A2I3HJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61853:NLGN4X
gene id: 61853:NLGN4X
uniprot id: A0A2I3FPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

61853:SLC10A6
gene id: 61853:SLC10A6
uniprot id: G1RE13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61853:LAMP2
gene id: 61853:LAMP2
uniprot id: A0A2I3GS77
uniprot id: G1RY84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

61853:MPV17
gene id: 61853:MPV17
uniprot id: G1QSP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

61853:STX12
gene id: 61853:STX12
uniprot id: A0A2I3G8I2
names: Similarity
messages: Belongs to the syntaxin family.

61853:COX2
gene id: 61853:COX2
uniprot id: D4QAT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61853:MYF5
gene id: 61853:MYF5
uniprot id: G1QZC6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

61853:PLAC1
gene id: 61853:PLAC1
uniprot id: G1QND4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

61853:PKP1
gene id: 61853:PKP1
uniprot id: A0A2I3G9V5
uniprot id: G1S8X3
names: Similarity
messages: Belongs to the beta-catenin family.

61853:SGPL1
gene id: 61853:SGPL1
uniprot id: A0A2I3HQK0
names: Similarity
messages: Belongs to the group II decarboxylase family.

61853:S100G
gene id: 61853:S100G
uniprot id: G1REG0
names: Similarity
messages: Belongs to the S-100 family.

61853:UPF3A
gene id: 61853:UPF3A
uniprot id: A0A2I3HVH8
uniprot id: G1R7L8
names: Similarity
messages: Belongs to the RENT3 family.

61853:LOC100591694
gene id: 61853:LOC100591694
uniprot id: G1SCC6
names: Subcellular Location Annotation
messages: Membrane

61853:RAPSN
gene id: 61853:RAPSN
uniprot id: A0A2I3H3E3
uniprot id: G1RX20
names: Similarity
messages: Belongs to the RAPsyn family.

61853:NEUROD1
gene id: 61853:NEUROD1
uniprot id: A0A2I3HW20
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:CXCR4
gene id: 61853:CXCR4
uniprot id: G1RC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell junction
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Late endosome
messages: Lysosome
messages: Membrane

61853:POLB
gene id: 61853:POLB
uniprot id: G1RQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

61853:CALR
gene id: 61853:CALR
uniprot id: G1RR67
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen
messages: Monomer.

61853:TBX4
gene id: 61853:TBX4
uniprot id: G1QHV7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:WDR55
gene id: 61853:WDR55
uniprot id: A0A2I3HIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

61853:MTIF2
gene id: 61853:MTIF2
uniprot id: G1RDE2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

61853:GAS8
gene id: 61853:GAS8
uniprot id: A0A2I3HBP2
uniprot id: A0A2I3HZ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

61853:GPX5
gene id: 61853:GPX5
uniprot id: A0A2I3GFP2
uniprot id: G1QX84
names: Similarity
messages: Belongs to the glutathione peroxidase family.

61853:DPH5
gene id: 61853:DPH5
uniprot id: G1RMS0
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

61853:SUMO2
gene id: 61853:SUMO2
uniprot id: A0A2I3H993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

61853:PHKA1
gene id: 61853:PHKA1
uniprot id: A0A2I3HWT0
uniprot id: G1S931
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

61853:USP15
gene id: 61853:USP15
uniprot id: A0A2I3FZN8
uniprot id: A0A2I3HDQ0
uniprot id: G1S5L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

61853:MAPRE2
gene id: 61853:MAPRE2
uniprot id: A0A2I3GFL2
uniprot id: G1R377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

61853:BZW2
gene id: 61853:BZW2
uniprot id: G1S3D2
names: Similarity
messages: Belongs to the BZW family.

61853:BCAT1
gene id: 61853:BCAT1
uniprot id: A0A2I3GPW5
uniprot id: G1QZ21
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

61853:TMEM254
gene id: 61853:TMEM254
uniprot id: A0A2I3HLS3
names: Subcellular Location Annotation
messages: Membrane

61853:DUSP26
gene id: 61853:DUSP26
uniprot id: A0A2I3HXT4
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61853:PAGE4
gene id: 61853:PAGE4
uniprot id: G1R9J0
names: Similarity
messages: Belongs to the GAGE family.

61853:EMC6
gene id: 61853:EMC6
uniprot id: G1S617
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:PYCR1
gene id: 61853:PYCR1
uniprot id: G1RHA1
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61853:AMPD2
gene id: 61853:AMPD2
uniprot id: A0A2I3GIT1
uniprot id: G1QS94
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61853:HPS3
gene id: 61853:HPS3
uniprot id: G1QRA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

61853:GSTM4
gene id: 61853:GSTM4
uniprot id: G1QSD7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

61853:CCDC86
gene id: 61853:CCDC86
uniprot id: G1RT87
names: Subcellular Location Annotation
messages: Nucleus

61853:SLA
gene id: 61853:SLA
uniprot id: G1R1H5
names: Subcellular Location Annotation
messages: Cytoplasm

61853:HPSE
gene id: 61853:HPSE
uniprot id: A0A2I3GYF1
uniprot id: G1RCW3
uniprot id: M3ZAM8
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

61853:BBS7
gene id: 61853:BBS7
uniprot id: G1RDU8
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

61853:SERF1A
gene id: 61853:SERF1A
uniprot id: A0A2I3G0K4
uniprot id: G1QWT3
names: Similarity
messages: Belongs to the SERF family.

61853:SRSF5
gene id: 61853:SRSF5
uniprot id: G1QM91
names: Similarity
messages: Belongs to the splicing factor SR family.

61853:CTSD
gene id: 61853:CTSD
uniprot id: G1RSC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

61853:PPP2R5C
gene id: 61853:PPP2R5C
uniprot id: A0A2I3G352
uniprot id: G1S0X1
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61853:PKP4
gene id: 61853:PKP4
uniprot id: A0A2I3GI20
uniprot id: G1QJM7
names: Similarity
messages: Belongs to the beta-catenin family.

61853:SLC35E3
gene id: 61853:SLC35E3
uniprot id: G1QUA0
names: Subcellular Location Annotation
messages: Membrane

61853:ITK
gene id: 61853:ITK
uniprot id: G1QV28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

61853:OPRPN
gene id: 61853:OPRPN
uniprot id: G1R817
names: Subcellular Location Annotation
messages: Secreted

61853:PSMB3
gene id: 61853:PSMB3
uniprot id: G1QIF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:CD207
gene id: 61853:CD207
uniprot id: G1RGW2
names: Subcellular Location Annotation
messages: Membrane

61853:TRAF2
gene id: 61853:TRAF2
uniprot id: G1RBD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

61853:INTS7
gene id: 61853:INTS7
uniprot id: G1QQY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

61853:OSMR
gene id: 61853:OSMR
uniprot id: G1S2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61853:MRFAP1
gene id: 61853:MRFAP1
uniprot id: G1RM71
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

61853:GARS1
gene id: 61853:GARS1
uniprot id: G1RYU4
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

61853:LOC100602571
gene id: 61853:LOC100602571
uniprot id: G1SCB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:CXXC1
gene id: 61853:CXXC1
uniprot id: G1RM78
names: Subcellular Location Annotation
messages: Nucleus

61853:HAPLN4
gene id: 61853:HAPLN4
uniprot id: A0A2I3GKZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:RPAP2
gene id: 61853:RPAP2
uniprot id: G1RHM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

61853:PDE4D
gene id: 61853:PDE4D
uniprot id: A0A2I3H789
uniprot id: A0A2I3HPP9
uniprot id: A0A2I3HPU2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:LOC100601477
gene id: 61853:LOC100601477
uniprot id: G1SAR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:ZDHHC8
gene id: 61853:ZDHHC8
uniprot id: A0A2I3FRR9
uniprot id: A0A2I3HZQ0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:LOC100596577
gene id: 61853:LOC100596577
uniprot id: G1SCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:THG1L
gene id: 61853:THG1L
uniprot id: G1QVS4
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

61853:MEA1
gene id: 61853:MEA1
uniprot id: G1QWX5
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

61853:CXXC4
gene id: 61853:CXXC4
uniprot id: G1RS94
names: Subcellular Location Annotation
messages: Cytoplasm

61853:ABCB6
gene id: 61853:ABCB6
uniprot id: G1RD55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: extracellular exosome
messages: multivesicular body membrane

61853:GPRC5A
gene id: 61853:GPRC5A
uniprot id: G1QU36
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:HAS2
gene id: 61853:HAS2
uniprot id: G1QZB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

61853:SEPSECS
gene id: 61853:SEPSECS
uniprot id: G1S4G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

61853:ERP29
gene id: 61853:ERP29
uniprot id: G1QGK9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

61853:HMGB1
gene id: 61853:HMGB1
uniprot id: G1QIX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

61853:CORO2A
gene id: 61853:CORO2A
uniprot id: G1S524
names: Similarity
messages: Belongs to the WD repeat coronin family.

61853:PDLIM1
gene id: 61853:PDLIM1
uniprot id: G1RRJ7
names: Subcellular Location Annotation
messages: Z line

61853:TRNT1
gene id: 61853:TRNT1
uniprot id: G1QSL5
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

61853:NMNAT2
gene id: 61853:NMNAT2
uniprot id: A0A2I3GQ64
uniprot id: G1S8Q0
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

61853:C23H8orf82
gene id: 61853:C23H8orf82
uniprot id: G1RJ30
names: Similarity
messages: Belongs to the UPF0598 family.

61853:PTGIS
gene id: 61853:PTGIS
uniprot id: A0A2I3I0B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
messages: Endoplasmic reticulum membrane

61853:SLC1A4
gene id: 61853:SLC1A4
uniprot id: G1RFV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

61853:KDM1B
gene id: 61853:KDM1B
uniprot id: G1QLZ6
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

61853:TREH
gene id: 61853:TREH
uniprot id: A0A2I3GQI6
uniprot id: G1R719
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

61853:INTU
gene id: 61853:INTU
uniprot id: G1RT77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

61853:SHOC2
gene id: 61853:SHOC2
uniprot id: G1S0C1
names: Function
names: Similarity
messages: Belongs to the SHOC2 family.
messages: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.

61853:NMUR2
gene id: 61853:NMUR2
uniprot id: G1S3C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

61853:GLP2R
gene id: 61853:GLP2R
uniprot id: G1RGH0
names: Subcellular Location Annotation
messages: Membrane

61853:CHRNA9
gene id: 61853:CHRNA9
uniprot id: G1S5P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:PMVK
gene id: 61853:PMVK
uniprot id: G1RL78
names: Subcellular Location Annotation
messages: cytosol

61853:LOC100580069
gene id: 61853:LOC100580069
uniprot id: G1RY04
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

61853:LOC100592283
gene id: 61853:LOC100592283
uniprot id: A0A2I3HVH0
uniprot id: G1RAP9
uniprot id: G1RAQ5
uniprot id: G1RAQ6
uniprot id: G1RAR0
uniprot id: G1RAR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

61853:MIF
gene id: 61853:MIF
uniprot id: G1QIN3
names: Similarity
messages: Belongs to the MIF family.

61853:PRDX6
gene id: 61853:PRDX6
uniprot id: A0A2I3GFG1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

61853:MCEE
gene id: 61853:MCEE
uniprot id: G1RH09
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

61853:KCTD20
gene id: 61853:KCTD20
uniprot id: M3ZB06
names: Subcellular Location Annotation
messages: Cytoplasm

61853:LOC100579523
gene id: 61853:LOC100579523
uniprot id: G1R2C4
names: Similarity
messages: Belongs to the MHC class I family.

61853:LOX
gene id: 61853:LOX
uniprot id: G1RMU7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Contains 1 lysine tyrosylquinone.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

61853:TMCC1
gene id: 61853:TMCC1
uniprot id: G1QZH9
names: Similarity
messages: Belongs to the TEX28 family.

61853:PMF1
gene id: 61853:PMF1
uniprot id: G1RPB2
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

61853:IL9
gene id: 61853:IL9
uniprot id: G1RA44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

61853:SLC39A7
gene id: 61853:SLC39A7
uniprot id: G1R529
names: Subcellular Location Annotation
messages: Membrane

61853:PDE6C
gene id: 61853:PDE6C
uniprot id: G1RQW6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:PRUNE1
gene id: 61853:PRUNE1
uniprot id: G1RGC0
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

61853:LOC101179385
gene id: 61853:LOC101179385
uniprot id: G1RHF3
names: Similarity
messages: Belongs to the S-100 family.

61853:GABARAPL1
gene id: 61853:GABARAPL1
uniprot id: A0A2I3GN03
uniprot id: A0A2I3HPG5
names: Similarity
messages: Belongs to the ATG8 family.

61853:COX1
gene id: 61853:COX1
uniprot id: S4UW59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61853:PPFIA1
gene id: 61853:PPFIA1
uniprot id: M3ZB00
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

61853:GAPDH
gene id: 61853:GAPDH
uniprot id: G1QVR0
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

61853:RO60
gene id: 61853:RO60
uniprot id: A0A2I3HJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

61853:ATP5MC2
gene id: 61853:ATP5MC2
uniprot id: G1S7H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

61853:MINAR1
gene id: 61853:MINAR1
uniprot id: G1RHC9
names: Similarity
messages: Belongs to the MINAR family.

61853:MFRP
gene id: 61853:MFRP
uniprot id: G1R747
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:VLDLR
gene id: 61853:VLDLR
uniprot id: G1RBJ9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: clathrin-coated pit

61853:CNOT11
gene id: 61853:CNOT11
uniprot id: G1RWI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

61853:CCDC85A
gene id: 61853:CCDC85A
uniprot id: G1RE16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

61853:PRPF4
gene id: 61853:PRPF4
uniprot id: A0A2I3GKW2
names: Subcellular Location Annotation
messages: Nucleus speckle

61853:SMIM19
gene id: 61853:SMIM19
uniprot id: A0A2I3H174
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

61853:CHEK1
gene id: 61853:CHEK1
uniprot id: A0A2I3GYB3
uniprot id: G1R7A0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

61853:PUS3
gene id: 61853:PUS3
uniprot id: G1R7A9
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

61853:ZNF280D
gene id: 61853:ZNF280D
uniprot id: G1R4N7
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor.
messages: Nucleus

61853:TMEM97
gene id: 61853:TMEM97
uniprot id: A0A2I3H6K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM97/sigma-2 receptor family.
messages: Endoplasmic reticulum membrane
messages: Interacts with NPC1.
messages: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.
messages: Membrane
messages: Nucleus membrane
messages: Rough endoplasmic reticulum membrane

61853:TCHP
gene id: 61853:TCHP
uniprot id: G1QPD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCHP family.
messages: cytoskeleton

61853:TOMM22
gene id: 61853:TOMM22
uniprot id: G1RYT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

61853:POLR2L
gene id: 61853:POLR2L
uniprot id: G1RBJ6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

61853:GALNT14
gene id: 61853:GALNT14
uniprot id: A0A2I3G5K2
uniprot id: G1S004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:BIRC7
gene id: 61853:BIRC7
uniprot id: G1RG16
names: Similarity
messages: Belongs to the IAP family.

61853:MICOS13
gene id: 61853:MICOS13
uniprot id: A0A2I3H0S7
uniprot id: G1RTJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

61853:ILK
gene id: 61853:ILK
uniprot id: G1S6P2
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

61853:ADCY8
gene id: 61853:ADCY8
uniprot id: G1R0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

61853:MPP2
gene id: 61853:MPP2
uniprot id: A0A2I3GYK9
uniprot id: A0A2I3HUA0
names: Similarity
messages: Belongs to the MAGUK family.

61853:EIF2B5
gene id: 61853:EIF2B5
uniprot id: G1R2K0
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

61853:LOC100602422
gene id: 61853:LOC100602422
uniprot id: A0A2I3GE69
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the 40S small ribosomal subunit.

61853:KCNC1
gene id: 61853:KCNC1
uniprot id: G1S7P7
names: Subcellular Location Annotation
messages: Membrane

61853:MGP
gene id: 61853:MGP
uniprot id: G1QV38
uniprot id: G1QV40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

61853:PRLR
gene id: 61853:PRLR
uniprot id: A0A2I3FZT0
uniprot id: A0A2I3H091
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

61853:CHMP4C
gene id: 61853:CHMP4C
uniprot id: G1QQI6
names: Similarity
messages: Belongs to the SNF7 family.

61853:GCLC
gene id: 61853:GCLC
uniprot id: A0A2I3H9B7
uniprot id: G1QTF2
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

61853:TMEM218
gene id: 61853:TMEM218
uniprot id: A0A2I3HHG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

61853:GUCY2D
gene id: 61853:GUCY2D
uniprot id: G1RFH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

61853:NAF1
gene id: 61853:NAF1
uniprot id: G1R3T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

61853:CDC42SE2
gene id: 61853:CDC42SE2
uniprot id: A0A2I3FV31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

61853:LOC100593890
gene id: 61853:LOC100593890
uniprot id: A0A2I3GNS3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:DHCR7
gene id: 61853:DHCR7
uniprot id: A0A2I3G7U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

61853:LOC100586250
gene id: 61853:LOC100586250
uniprot id: A0A2I3H9B6
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

61853:INPP4B
gene id: 61853:INPP4B
uniprot id: G1QZT9
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

61853:GHSR
gene id: 61853:GHSR
uniprot id: G1R0I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

61853:LCOR
gene id: 61853:LCOR
uniprot id: A0A2I3HA63
names: Subcellular Location Annotation
messages: Nucleus

61853:MZF1
gene id: 61853:MZF1
uniprot id: G1RK99
names: Subcellular Location Annotation
messages: Nucleus

61853:OLAH
gene id: 61853:OLAH
uniprot id: G1RP21
names: Similarity
messages: Belongs to the thioesterase family.

61853:TPM2
gene id: 61853:TPM2
uniprot id: G1QWA1
uniprot id: M3ZA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61853:ZACN
gene id: 61853:ZACN
uniprot id: G1QNM8
names: Subcellular Location Annotation
messages: Membrane

61853:OSBP
gene id: 61853:OSBP
uniprot id: G1RRK0
names: Similarity
messages: Belongs to the OSBP family.

61853:IFT46
gene id: 61853:IFT46
uniprot id: A0A2I3GX77
uniprot id: G1R716
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

61853:PEX5L
gene id: 61853:PEX5L
uniprot id: A0A2I3GSI6
uniprot id: A0A2I3GWU3
uniprot id: A0A2I3GXC7
uniprot id: A0A2I3HSL8
uniprot id: G1R1R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

61853:TAF12
gene id: 61853:TAF12
uniprot id: G1RFH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

61853:LOC100587920
gene id: 61853:LOC100587920
uniprot id: G1SC77
names: Subcellular Location Annotation
messages: Membrane

61853:CDK1
gene id: 61853:CDK1
uniprot id: A0A2I3G9U5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:HADHB
gene id: 61853:HADHB
uniprot id: G1QNG1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61853:IGFL1
gene id: 61853:IGFL1
uniprot id: G1QPX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

61853:RASGRP3
gene id: 61853:RASGRP3
uniprot id: A0A2I3GH82
names: Similarity
messages: Belongs to the RASGRP family.

61853:TUBA8
gene id: 61853:TUBA8
uniprot id: A0A2I3HFV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61853:GPSM2
gene id: 61853:GPSM2
uniprot id: G1QNT0
names: Similarity
messages: Belongs to the GPSM family.

61853:BCLAF1
gene id: 61853:BCLAF1
uniprot id: A0A2I3HYX0
uniprot id: G1RXM4
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

61853:PRMT5
gene id: 61853:PRMT5
uniprot id: G1RXT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

61853:TPM1
gene id: 61853:TPM1
uniprot id: A0A2I3GPN2
uniprot id: A0A2I3GU60
uniprot id: A0A2I3H4R9
uniprot id: A0A2I3H6A4
uniprot id: A0A2I3HFZ5
uniprot id: A0A2I3HVE9
uniprot id: G1RNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61853:GPRIN3
gene id: 61853:GPRIN3
uniprot id: G1SAB7
names: Function
messages: May be involved in neurite outgrowth.

61853:ZNF197
gene id: 61853:ZNF197
uniprot id: A0A2I3GTQ2
uniprot id: G1R201
names: Subcellular Location Annotation
messages: Nucleus

61853:FREM3
gene id: 61853:FREM3
uniprot id: G1R043
names: Similarity
messages: Belongs to the FRAS1 family.

61853:CXCL8
gene id: 61853:CXCL8
uniprot id: A0A2I3HR56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

61853:CDH9
gene id: 61853:CDH9
uniprot id: G1RN01
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:NRG1
gene id: 61853:NRG1
uniprot id: A0A2I3GPY6
uniprot id: A0A2I3GY30
uniprot id: A0A2I3HCM6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

61853:DIS3
gene id: 61853:DIS3
uniprot id: A0A2I3GDS2
uniprot id: G1S1W4
names: Similarity
messages: Belongs to the RNR ribonuclease family.

61853:LOC100595123
gene id: 61853:LOC100595123
uniprot id: A0A2I3HE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

61853:PGLYRP4
gene id: 61853:PGLYRP4
uniprot id: G1RHE1
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

61853:FGF21
gene id: 61853:FGF21
uniprot id: G1QXG8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:PDCL3
gene id: 61853:PDCL3
uniprot id: G1RW77
names: Similarity
messages: Belongs to the phosducin family.

61853:USP7
gene id: 61853:USP7
uniprot id: G1RGG6
names: Similarity
messages: Belongs to the peptidase C19 family.

61853:OTUB2
gene id: 61853:OTUB2
uniprot id: G1S5Z2
names: Similarity
messages: Belongs to the peptidase C65 family.

61853:LOC100592962
gene id: 61853:LOC100592962
uniprot id: G1SBF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

61853:SLF2
gene id: 61853:SLF2
uniprot id: G1RXM1
names: Similarity
messages: Belongs to the FAM178 family.

61853:INPP4A
gene id: 61853:INPP4A
uniprot id: A0A2I3GSY8
uniprot id: A0A2I3H1M3
uniprot id: A0A2I3H4A0
names: Similarity
messages: Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

61853:SLC30A4
gene id: 61853:SLC30A4
uniprot id: G1R1Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61853:PSMD6
gene id: 61853:PSMD6
uniprot id: A0A2I3HNI5
uniprot id: G1RMC4
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

61853:LIPM
gene id: 61853:LIPM
uniprot id: G1RNL2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61853:TUBGCP5
gene id: 61853:TUBGCP5
uniprot id: G1RJN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

61853:ADSS2
gene id: 61853:ADSS2
uniprot id: A0A2I3GZL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

61853:KCNS1
gene id: 61853:KCNS1
uniprot id: G1R4K5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:TNFSF8
gene id: 61853:TNFSF8
uniprot id: A0A2I3HUZ1
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61853:MANBAL
gene id: 61853:MANBAL
uniprot id: G1R344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

61853:TGM3
gene id: 61853:TGM3
uniprot id: G1RDJ9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61853:C15H11orf54
gene id: 61853:C15H11orf54
uniprot id: A0A2I3GUC7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

61853:C4H18orf21
gene id: 61853:C4H18orf21
uniprot id: A0A2I3GKV6
names: Similarity
messages: Belongs to the UPF0711 family.

61853:PCSK2
gene id: 61853:PCSK2
uniprot id: G1REW0
names: Similarity
messages: Belongs to the peptidase S8 family.

61853:RAX2
gene id: 61853:RAX2
uniprot id: G1QR43
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CRX.
messages: May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter.
messages: Nucleus

61853:CA2
gene id: 61853:CA2
uniprot id: G1QRL6
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61853:GRID1
gene id: 61853:GRID1
uniprot id: G1QNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

61853:TTC4
gene id: 61853:TTC4
uniprot id: G1QS80
names: Similarity
messages: Belongs to the TTC4 family.

61853:FAM98A
gene id: 61853:FAM98A
uniprot id: G1S1Q0
names: Similarity
messages: Belongs to the FAM98 family.

61853:XCR1
gene id: 61853:XCR1
uniprot id: G1R2I4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:CRBN
gene id: 61853:CRBN
uniprot id: G1QSV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

61853:THRB
gene id: 61853:THRB
uniprot id: A0A2I3FV35
uniprot id: G1QTX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61853:ERLEC1
gene id: 61853:ERLEC1
uniprot id: G1RCI8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

61853:DKK2
gene id: 61853:DKK2
uniprot id: A0A2I3HC56
names: Similarity
messages: Belongs to the dickkopf family.

61853:DEFA5
gene id: 61853:DEFA5
uniprot id: G1RY43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

61853:GALNT13
gene id: 61853:GALNT13
uniprot id: A0A2I3HN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:KHDC1L
gene id: 61853:KHDC1L
uniprot id: G1QKD7
names: Similarity
messages: Belongs to the KHDC1 family.

61853:TFB2M
gene id: 61853:TFB2M
uniprot id: G1QVP7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

61853:DBP
gene id: 61853:DBP
uniprot id: G1QX60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

61853:ATF2
gene id: 61853:ATF2
uniprot id: A0A2I3GRA9
uniprot id: A0A2I3HRN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA.
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').

61853:NOXRED1
gene id: 61853:NOXRED1
uniprot id: G1S466
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61853:LOC100593118
gene id: 61853:LOC100593118
uniprot id: A0A2I3HZK5
names: Subcellular Location Annotation
messages: Chromosome

61853:ABCG2
gene id: 61853:ABCG2
uniprot id: G1REW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

61853:TMED6
gene id: 61853:TMED6
uniprot id: G1R0D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:HNRNPA2B1
gene id: 61853:HNRNPA2B1
uniprot id: A0A2I3H506
uniprot id: G1RY30
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

61853:MBOAT4
gene id: 61853:MBOAT4
uniprot id: G1RMI9
names: Subcellular Location Annotation
messages: Membrane

61853:HDDC2
gene id: 61853:HDDC2
uniprot id: G1RUM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

61853:SERPINI1
gene id: 61853:SERPINI1
uniprot id: G1QYD3
names: Similarity
messages: Belongs to the serpin family.

61853:BTF3L4
gene id: 61853:BTF3L4
uniprot id: A0A2I3G0R7
names: Similarity
messages: Belongs to the NAC-beta family.

61853:GABBR2
gene id: 61853:GABBR2
uniprot id: G1S578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

61853:PLPP5
gene id: 61853:PLPP5
uniprot id: A0A2I3HDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61853:FAM168A
gene id: 61853:FAM168A
uniprot id: A0A2I3GVF0
uniprot id: A0A2I3HG04
names: Similarity
messages: Belongs to the FAM168 family.

61853:SEC13
gene id: 61853:SEC13
uniprot id: G1QWZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

61853:CFTR
gene id: 61853:CFTR
uniprot id: G1RLX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Recycling endosome membrane

61853:CPB2
gene id: 61853:CPB2
uniprot id: A0A2I3FWS6
uniprot id: G1QQD0
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:ADGRG2
gene id: 61853:ADGRG2
uniprot id: A0A2I3G4P7
uniprot id: A0A2I3GCH3
uniprot id: A0A2I3HP76
uniprot id: A0A2I3HQB7
uniprot id: G1RFD9
uniprot id: M3Z9Q2
names: Subcellular Location Annotation
messages: Membrane

61853:SNRNP27
gene id: 61853:SNRNP27
uniprot id: G1RGK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

61853:PIP
gene id: 61853:PIP
uniprot id: G1QRT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.
messages: Secreted

61853:TLR2
gene id: 61853:TLR2
uniprot id: G1SB95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
messages: Membrane
messages: Membrane raft
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: phagosome membrane

61853:TSHZ2
gene id: 61853:TSHZ2
uniprot id: A0A2I3HXZ5
uniprot id: G1R5T2
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

61853:TRAK2
gene id: 61853:TRAK2
uniprot id: G1R5L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

61853:BBS2
gene id: 61853:BBS2
uniprot id: G1QNZ0
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

61853:KCNK10
gene id: 61853:KCNK10
uniprot id: A0A2I3HW31
uniprot id: G1S4S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61853:PIGV
gene id: 61853:PIGV
uniprot id: G1RDW5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

61853:LAD1
gene id: 61853:LAD1
uniprot id: G1S8X6
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

61853:PEX3
gene id: 61853:PEX3
uniprot id: G1RYK7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

61853:NUMB
gene id: 61853:NUMB
uniprot id: A0A2I3HE81
uniprot id: G1QRY2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

61853:UBE3D
gene id: 61853:UBE3D
uniprot id: G1RPW0
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

61853:FARSA
gene id: 61853:FARSA
uniprot id: G1RR50
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

61853:VPS11
gene id: 61853:VPS11
uniprot id: G1R733
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

61853:MED8
gene id: 61853:MED8
uniprot id: A0A2I3HT22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:CTSO
gene id: 61853:CTSO
uniprot id: A0A2I3H0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61853:NPLOC4
gene id: 61853:NPLOC4
uniprot id: A0A2I3H3D7
names: Similarity
messages: Belongs to the NPL4 family.

61853:LEPROTL1
gene id: 61853:LEPROTL1
uniprot id: A0A2I3HLI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

61853:LOC100583757
gene id: 61853:LOC100583757
uniprot id: G1QU07
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61853:LOC100600937
gene id: 61853:LOC100600937
uniprot id: G1SA53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

61853:LOC100606871
gene id: 61853:LOC100606871
uniprot id: A0A2I3H7Y1
names: Similarity
messages: Belongs to the strictosidine synthase family.

61853:MNAT1
gene id: 61853:MNAT1
uniprot id: A0A2I3I007
uniprot id: G1RU18
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

61853:SMIM8
gene id: 61853:SMIM8
uniprot id: A0A2I3GW00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

61853:GPHN
gene id: 61853:GPHN
uniprot id: G1QI49
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

61853:IL11RA
gene id: 61853:IL11RA
uniprot id: H9HA20
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

61853:UBL3
gene id: 61853:UBL3
uniprot id: G1QIP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:PSMD12
gene id: 61853:PSMD12
uniprot id: A0A2I3HX67
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

61853:CD38
gene id: 61853:CD38
uniprot id: A0A2I3G9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

61853:MPEG1
gene id: 61853:MPEG1
uniprot id: G1SCC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPEG1 family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

61853:MMP3
gene id: 61853:MMP3
uniprot id: G1R6D5
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:UBE2C
gene id: 61853:UBE2C
uniprot id: A0A2I3HKD6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:MRPL16
gene id: 61853:MRPL16
uniprot id: G1RRR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

61853:KCTD10
gene id: 61853:KCTD10
uniprot id: G1QM64
names: Similarity
messages: Belongs to the BACURD family.

61853:RPL37A
gene id: 61853:RPL37A
uniprot id: A0A2I3GET7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

61853:FTL
gene id: 61853:FTL
uniprot id: G1QXR8
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61853:CHIA
gene id: 61853:CHIA
uniprot id: G1QUR7
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.

61853:PDK3
gene id: 61853:PDK3
uniprot id: G1RGB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61853:TMA16
gene id: 61853:TMA16
uniprot id: A0A2I3HP04
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

61853:ZDHHC16
gene id: 61853:ZDHHC16
uniprot id: A0A2I3G341
uniprot id: A0A2I3GMJ0
uniprot id: G1RUQ2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:NAXE
gene id: 61853:NAXE
uniprot id: G1RQ60
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

61853:ERG28
gene id: 61853:ERG28
uniprot id: G1S3F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:RRM1
gene id: 61853:RRM1
uniprot id: G1S6A0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

61853:TOPAZ1
gene id: 61853:TOPAZ1
uniprot id: G1R1V8
names: Function
names: Subcellular Location Annotation
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
messages: cytosol

61853:BRINP1
gene id: 61853:BRINP1
uniprot id: G1S4X0
names: Similarity
messages: Belongs to the BRINP family.

61853:PAIP2B
gene id: 61853:PAIP2B
uniprot id: A0A2I3HXF9
names: Similarity
messages: Belongs to the PAIP2 family.

61853:DUSP6
gene id: 61853:DUSP6
uniprot id: A0A2I3HLJ1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61853:PLA2G1B
gene id: 61853:PLA2G1B
uniprot id: G1S0C2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61853:ERBB4
gene id: 61853:ERBB4
uniprot id: G1R6F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

61853:DEFB123
gene id: 61853:DEFB123
uniprot id: G1REJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:ACOT4
gene id: 61853:ACOT4
uniprot id: G1S1S4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61853:LOC100602452
gene id: 61853:LOC100602452
uniprot id: G1S992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:GFRA4
gene id: 61853:GFRA4
uniprot id: G1R7U5
names: Similarity
messages: Belongs to the GDNFR family.

61853:OIP5
gene id: 61853:OIP5
uniprot id: A0A2I3GI92
names: Function
names: Subcellular Location Annotation
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

61853:BPGM
gene id: 61853:BPGM
uniprot id: G1RRM9
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61853:ACSM3
gene id: 61853:ACSM3
uniprot id: G1RP53
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61853:EMSY
gene id: 61853:EMSY
uniprot id: A0A2I3GUW3
uniprot id: A0A2I3HLV2
uniprot id: A0A2I3I018
names: Subcellular Location Annotation
messages: Nucleus

61853:NCF2
gene id: 61853:NCF2
uniprot id: G1S8Q4
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

61853:SLC25A40
gene id: 61853:SLC25A40
uniprot id: G1RYC9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

61853:CRYBA2
gene id: 61853:CRYBA2
uniprot id: G1RCN8
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61853:LSM5
gene id: 61853:LSM5
uniprot id: G1RZ54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

61853:SEMA6D
gene id: 61853:SEMA6D
uniprot id: A0A2I3H4E0
uniprot id: A0A2I3HDC8
uniprot id: G1R1V9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CDK5R2
gene id: 61853:CDK5R2
uniprot id: G1SAQ5
names: Similarity
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Heterodimer of a catalytic subunit and a regulatory subunit.

61853:C12H1orf43
gene id: 61853:C12H1orf43
uniprot id: A0A2I3GR63
uniprot id: A0A2I3GY57
names: Function
names: Subcellular Location Annotation
messages: General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion

61853:LOC100598362
gene id: 61853:LOC100598362
uniprot id: A0A2I3G4V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:GLUD2
gene id: 61853:GLUD2
uniprot id: G1S9P7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

61853:ACTL7B
gene id: 61853:ACTL7B
uniprot id: G1SBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

61853:RAPGEF2
gene id: 61853:RAPGEF2
uniprot id: A0A2I3GDC5
uniprot id: A0A2I3GT96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAPGEF2 family.
messages: Cell junction
messages: Endosome
messages: Late endosome
messages: perinuclear region

61853:TARS2
gene id: 61853:TARS2
uniprot id: A0A2I3GTP4
uniprot id: G1RFM9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61853:LOC100586992
gene id: 61853:LOC100586992
uniprot id: A0A2I3HRJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:LYRM4
gene id: 61853:LYRM4
uniprot id: A0A2I3GUA2
uniprot id: A0A2I3H651
names: Similarity
messages: Belongs to the complex I LYR family.

61853:TCEAL1
gene id: 61853:TCEAL1
uniprot id: A0A2I3GX99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

61853:SSBP1
gene id: 61853:SSBP1
uniprot id: G1QPH4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

61853:HOXA2
gene id: 61853:HOXA2
uniprot id: G1RY83
names: Subcellular Location Annotation
messages: Nucleus

61853:GTF2E1
gene id: 61853:GTF2E1
uniprot id: G1QZ47
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

61853:DIMT1
gene id: 61853:DIMT1
uniprot id: A0A2I3H2J0
uniprot id: G1QRZ3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

61853:REV1
gene id: 61853:REV1
uniprot id: G1RVV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

61853:CLRN2
gene id: 61853:CLRN2
uniprot id: G1S3P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

61853:GPR182
gene id: 61853:GPR182
uniprot id: G1S6L9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:PPP1R14B
gene id: 61853:PPP1R14B
uniprot id: G1QYA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

61853:LPIN1
gene id: 61853:LPIN1
uniprot id: A0A2I3GB02
names: Similarity
messages: Belongs to the lipin family.

61853:TSPAN8
gene id: 61853:TSPAN8
uniprot id: G1QW97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:TBCE
gene id: 61853:TBCE
uniprot id: A0A2I3HRZ7
uniprot id: G1QRK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Cytoplasm

61853:EPO
gene id: 61853:EPO
uniprot id: G1RMP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

61853:TMEM41B
gene id: 61853:TMEM41B
uniprot id: G1S719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

61853:TMEM230
gene id: 61853:TMEM230
uniprot id: G1R857
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

61853:IL26
gene id: 61853:IL26
uniprot id: G1QTG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

61853:SNX30
gene id: 61853:SNX30
uniprot id: A0A2I3GAI5
names: Similarity
messages: Belongs to the sorting nexin family.

61853:CD200R1
gene id: 61853:CD200R1
uniprot id: G1QWL2
names: Similarity
messages: Belongs to the CD200R family.

61853:TGM5
gene id: 61853:TGM5
uniprot id: G1QYC6
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61853:LOC100592128
gene id: 61853:LOC100592128
uniprot id: A0A2I3HWC5
names: Similarity
messages: Belongs to the NDK family.

61853:GTF2A2
gene id: 61853:GTF2A2
uniprot id: A0A2I3HGK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

61853:SORBS2
gene id: 61853:SORBS2
uniprot id: G1RKW5
names: Subcellular Location Annotation
messages: focal adhesion

61853:KRT5
gene id: 61853:KRT5
uniprot id: G1S7Q6
names: Similarity
messages: Belongs to the intermediate filament family.

61853:LOC100583662
gene id: 61853:LOC100583662
uniprot id: G1SC05
names: Subcellular Location Annotation
messages: Membrane

61853:PLAT
gene id: 61853:PLAT
uniprot id: A0A2I3GC18
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:DPH2
gene id: 61853:DPH2
uniprot id: A0A2I3H0Y5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

61853:COX3
gene id: 61853:COX3
uniprot id: E7EAE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

61853:SESN3
gene id: 61853:SESN3
uniprot id: G1R663
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

61853:LALBA
gene id: 61853:LALBA
uniprot id: G1S884
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

61853:EFEMP2
gene id: 61853:EFEMP2
uniprot id: G1R1T3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MED18
gene id: 61853:MED18
uniprot id: G1RFC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:FZD3
gene id: 61853:FZD3
uniprot id: G1S3V5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:LZTS2
gene id: 61853:LZTS2
uniprot id: G1RXP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

61853:FAM83F
gene id: 61853:FAM83F
uniprot id: G1RZA1
names: Similarity
messages: Belongs to the FAM83 family.

61853:DCLRE1C
gene id: 61853:DCLRE1C
uniprot id: E5FGH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

61853:MT1HL1
gene id: 61853:MT1HL1
uniprot id: G1SB16
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:PCSK5
gene id: 61853:PCSK5
uniprot id: A0A2I3GVQ1
uniprot id: G1QNB0
names: Similarity
messages: Belongs to the peptidase S8 family.

61853:HAL
gene id: 61853:HAL
uniprot id: A0A2I3GI78
uniprot id: G1R1R0
names: Similarity
messages: Belongs to the PAL/histidase family.

61853:MED22
gene id: 61853:MED22
uniprot id: G1RRK4
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

61853:HRH2
gene id: 61853:HRH2
uniprot id: G1QIC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PLK2
gene id: 61853:PLK2
uniprot id: G1QQ83
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

61853:APOA1
gene id: 61853:APOA1
uniprot id: G1R6X5
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

61853:RHAG
gene id: 61853:RHAG
uniprot id: G1QVQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

61853:CHAC2
gene id: 61853:CHAC2
uniprot id: G1RC96
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

61853:MOCS2
gene id: 61853:MOCS2
uniprot id: G1RJJ3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

61853:MAB21L3
gene id: 61853:MAB21L3
uniprot id: G1QYT3
names: Similarity
messages: Belongs to the mab-21 family.

61853:UXS1
gene id: 61853:UXS1
uniprot id: G1RIR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

61853:TRPC7
gene id: 61853:TRPC7
uniprot id: A0A2I3G2F8
uniprot id: A0A2I3H5B3
uniprot id: A0A2I3HRP5
names: Subcellular Location Annotation
messages: Membrane

61853:ARF4
gene id: 61853:ARF4
uniprot id: A0A2I3H955
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61853:LTA
gene id: 61853:LTA
uniprot id: G1R2J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

61853:DIP2B
gene id: 61853:DIP2B
uniprot id: A0A2I3HLZ2
names: Similarity
messages: Belongs to the DIP2 family.

61853:PCNX2
gene id: 61853:PCNX2
uniprot id: G1QPU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

61853:INSIG2
gene id: 61853:INSIG2
uniprot id: G1RMF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

61853:CTNNA3
gene id: 61853:CTNNA3
uniprot id: G1RN12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: cytoskeleton

61853:RNASEH2A
gene id: 61853:RNASEH2A
uniprot id: G1RQQ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

61853:SATB1
gene id: 61853:SATB1
uniprot id: A0A2I3HB41
uniprot id: G1QJI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61853:ITIH1
gene id: 61853:ITIH1
uniprot id: G1R6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61853:SPSB1
gene id: 61853:SPSB1
uniprot id: A0A2I3H020
names: Similarity
messages: Belongs to the SPSB family.

61853:S100A6
gene id: 61853:S100A6
uniprot id: G1RHF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
messages: Nucleus envelope

61853:CHRND
gene id: 61853:CHRND
uniprot id: G1RVV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:ADAMTS16
gene id: 61853:ADAMTS16
uniprot id: G1RKF9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:SLC27A2
gene id: 61853:SLC27A2
uniprot id: A0A2I3GWT7
uniprot id: G1R2W0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61853:LOC100596435
gene id: 61853:LOC100596435
uniprot id: G1RWL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

61853:FAM133A
gene id: 61853:FAM133A
uniprot id: G1SBJ9
names: Similarity
messages: Belongs to the FAM133 family.

61853:SVOPL
gene id: 61853:SVOPL
uniprot id: G1RU70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61853:SERPINB11
gene id: 61853:SERPINB11
uniprot id: A0A2I3GI29
uniprot id: G1RC86
names: Similarity
messages: Belongs to the serpin family.

61853:PYM1
gene id: 61853:PYM1
uniprot id: A0A2I3HHT0
uniprot id: G1S755
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pym family.
messages: Cytoplasm
messages: Interacts (via N-terminus) with magoh and rbm8a; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.

61853:SUPV3L1
gene id: 61853:SUPV3L1
uniprot id: G1RLC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

61853:SPACA4
gene id: 61853:SPACA4
uniprot id: A0A2I3HX42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

61853:SPAST
gene id: 61853:SPAST
uniprot id: A0A2I3GDR1
uniprot id: G1S0D4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.
messages: Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.
messages: Belongs to the AAA ATPase family. Spastin subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.
messages: Membrane
messages: Midbody
messages: Nucleus
messages: axon
messages: centrosome
messages: cytoskeleton
messages: perinuclear region
messages: spindle

61853:TFAP2B
gene id: 61853:TFAP2B
uniprot id: G1QV41
names: Similarity
messages: Belongs to the AP-2 family.

61853:PAPPA
gene id: 61853:PAPPA
uniprot id: G1S4T4
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:ZSCAN29
gene id: 61853:ZSCAN29
uniprot id: G1QYG8
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61853:AP4B1
gene id: 61853:AP4B1
uniprot id: G1QX99
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61853:RPS15
gene id: 61853:RPS15
uniprot id: A0A2I3HTW0
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

61853:ELMO2
gene id: 61853:ELMO2
uniprot id: A0A2I3GSJ0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

61853:CFAP97D1
gene id: 61853:CFAP97D1
uniprot id: A0A2I3HCQ5
names: Similarity
messages: Belongs to the CFAP97 family.

61853:LOC100587351
gene id: 61853:LOC100587351
uniprot id: G1QTT2
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

61853:TBRG1
gene id: 61853:TBRG1
uniprot id: G1R778
names: Subcellular Location Annotation
messages: Nucleus

61853:TRABD2A
gene id: 61853:TRABD2A
uniprot id: A0A2I3HL05
uniprot id: A0A2I3HV12
uniprot id: G1QL35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

61853:AKIRIN2
gene id: 61853:AKIRIN2
uniprot id: G1RRH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

61853:FOXP1
gene id: 61853:FOXP1
uniprot id: A0A2I3H606
uniprot id: A0A2I3H9H6
names: Subcellular Location Annotation
messages: Nucleus

61853:TAS2R38
gene id: 61853:TAS2R38
uniprot id: G1S9X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane
messages: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

61853:TMPRSS11A
gene id: 61853:TMPRSS11A
uniprot id: G1RD87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61853:MTF2
gene id: 61853:MTF2
uniprot id: A0A2I3G3M5
uniprot id: G1RI07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

61853:KCNN1
gene id: 61853:KCNN1
uniprot id: A0A2I3GPQ5
names: Subcellular Location Annotation
messages: Membrane

61853:EPHB6
gene id: 61853:EPHB6
uniprot id: G1QQV9
names: Subcellular Location Annotation
messages: Membrane

61853:PLSCR1
gene id: 61853:PLSCR1
uniprot id: G1QPF0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61853:PARD6A
gene id: 61853:PARD6A
uniprot id: G1QY37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

61853:EIF4E2
gene id: 61853:EIF4E2
uniprot id: A0A2I3GL96
uniprot id: A0A2I3H4M1
uniprot id: A0A2I3HUT2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

61853:PIGF
gene id: 61853:PIGF
uniprot id: A0A2I3GKT2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:RPP14
gene id: 61853:RPP14
uniprot id: A0A2I3HM53
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

61853:ETV1
gene id: 61853:ETV1
uniprot id: A0A2I3GJA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:ASB8
gene id: 61853:ASB8
uniprot id: G1S889
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

61853:TDRD5
gene id: 61853:TDRD5
uniprot id: A0A2I3HG77
uniprot id: G1S0W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

61853:SPOUT1
gene id: 61853:SPOUT1
uniprot id: G1S7A0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

61853:COG3
gene id: 61853:COG3
uniprot id: G1QPS2
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

61853:RPS23
gene id: 61853:RPS23
uniprot id: A0A2I3GPZ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

61853:C5H1orf74
gene id: 61853:C5H1orf74
uniprot id: G1QN20
names: Similarity
messages: Belongs to the UPF0739 family.

61853:TNFRSF19
gene id: 61853:TNFRSF19
uniprot id: A0A2I3HRK4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:EFEMP1
gene id: 61853:EFEMP1
uniprot id: G1RE04
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:NFX1
gene id: 61853:NFX1
uniprot id: A0A2I3H3Z3
uniprot id: G1QZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

61853:SQLE
gene id: 61853:SQLE
uniprot id: G1R0I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

61853:PARP10
gene id: 61853:PARP10
uniprot id: G1QPS4
names: Similarity
messages: Belongs to the ARTD/PARP family.

61853:SZRD1
gene id: 61853:SZRD1
uniprot id: A0A2I3HBV6
uniprot id: G1R8I4
names: Similarity
messages: Belongs to the SZRD1 family.

61853:OAS2
gene id: 61853:OAS2
uniprot id: G1QGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

61853:SNRPB
gene id: 61853:SNRPB
uniprot id: A0A2I3H907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

61853:EVA1B
gene id: 61853:EVA1B
uniprot id: A0A2I3HMD7
names: Similarity
messages: Belongs to the EVA1 family.

61853:LOC100594097
gene id: 61853:LOC100594097
uniprot id: G1R9V1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:SULT1E1
gene id: 61853:SULT1E1
uniprot id: G1R7X4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:RIPPLY1
gene id: 61853:RIPPLY1
uniprot id: A0A2I3G522
uniprot id: G1RU63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

61853:SLC39A6
gene id: 61853:SLC39A6
uniprot id: G1R2Y1
names: Subcellular Location Annotation
messages: Membrane

61853:HNRNPF
gene id: 61853:HNRNPF
uniprot id: G1SBQ3
names: Subcellular Location Annotation
messages: nucleoplasm

61853:CACNG3
gene id: 61853:CACNG3
uniprot id: G1RMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

61853:TMEM258
gene id: 61853:TMEM258
uniprot id: G1QS60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

61853:LYN
gene id: 61853:LYN
uniprot id: G1QKJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61853:CLCF1
gene id: 61853:CLCF1
uniprot id: G1R3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

61853:C18H10orf53
gene id: 61853:C18H10orf53
uniprot id: A0A2I3GU87
names: Similarity
messages: Belongs to the UPF0728 family.

61853:F3
gene id: 61853:F3
uniprot id: G1RJV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

61853:MS4A7
gene id: 61853:MS4A7
uniprot id: A0A2I3FPU1
names: Similarity
messages: Belongs to the MS4A family.

61853:TSPAN2
gene id: 61853:TSPAN2
uniprot id: G1QYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:BMP10
gene id: 61853:BMP10
uniprot id: G1RG92
names: Similarity
messages: Belongs to the TGF-beta family.

61853:HTR1F
gene id: 61853:HTR1F
uniprot id: G1SAH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

61853:RAMP1
gene id: 61853:RAMP1
uniprot id: G1RJX9
names: Similarity
messages: Belongs to the RAMP family.

61853:TMEM106B
gene id: 61853:TMEM106B
uniprot id: G1S2E2
names: Similarity
messages: Belongs to the TMEM106 family.

61853:LOC100602990
gene id: 61853:LOC100602990
uniprot id: A0A2I3GGW8
names: Similarity
messages: Belongs to the MHC class II family.

61853:LOC100606037
gene id: 61853:LOC100606037
uniprot id: G1QL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

61853:AGAP1
gene id: 61853:AGAP1
uniprot id: A0A2I3HJT6
names: Similarity
messages: Belongs to the centaurin gamma-like family.

61853:LOC100601648
gene id: 61853:LOC100601648
uniprot id: A0A2I3GZ19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61853:BIRC3
gene id: 61853:BIRC3
uniprot id: G1R6A7
names: Similarity
messages: Belongs to the IAP family.

61853:LRRFIP2
gene id: 61853:LRRFIP2
uniprot id: A0A2I3GP66
names: Similarity
messages: Belongs to the LRRFIP family.

61853:PCYOX1L
gene id: 61853:PCYOX1L
uniprot id: G1RGP0
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

61853:C4H18orf32
gene id: 61853:C4H18orf32
uniprot id: G1RLD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

61853:TMEM17
gene id: 61853:TMEM17
uniprot id: G1RF86
names: Subcellular Location Annotation
messages: Membrane

61853:LYG1
gene id: 61853:LYG1
uniprot id: G1QNW9
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

61853:INTS9
gene id: 61853:INTS9
uniprot id: G1S418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

61853:COQ7
gene id: 61853:COQ7
uniprot id: A0A2I3H0N0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.
messages: Mitochondrion inner membrane

61853:GLCE
gene id: 61853:GLCE
uniprot id: G1RSR8
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

61853:MB
gene id: 61853:MB
uniprot id: G1RW45
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

61853:G6PC2
gene id: 61853:G6PC2
uniprot id: A0A2I3GZ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

61853:CDH2
gene id: 61853:CDH2
uniprot id: G1R423
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Cell surface
messages: Membrane
messages: sarcolemma

61853:METTL4
gene id: 61853:METTL4
uniprot id: G1R593
names: Similarity
messages: Belongs to the MT-A70-like family.

61853:EIF3J
gene id: 61853:EIF3J
uniprot id: A0A2I3HVU7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

61853:VNN1
gene id: 61853:VNN1
uniprot id: G1RWW1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

61853:BAIAP2
gene id: 61853:BAIAP2
uniprot id: A0A2I3G2R2
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

61853:GAD2
gene id: 61853:GAD2
uniprot id: G1S4I7
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61853:PARG
gene id: 61853:PARG
uniprot id: A0A2I3HT36
names: Similarity
messages: Belongs to the poly(ADP-ribose) glycohydrolase family.

61853:RPP30
gene id: 61853:RPP30
uniprot id: G1RP82
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

61853:E2F6
gene id: 61853:E2F6
uniprot id: A0A2I3GWE2
uniprot id: G1RVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61853:FHL5
gene id: 61853:FHL5
uniprot id: G1RT37
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

61853:KLHL3
gene id: 61853:KLHL3
uniprot id: G1RAX9
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

61853:MED9
gene id: 61853:MED9
uniprot id: G1RT49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:NR2F2
gene id: 61853:NR2F2
uniprot id: A0A2I3HRX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61853:MARK3
gene id: 61853:MARK3
uniprot id: A0A2I3H797
uniprot id: A0A2I3HZ00
uniprot id: G1S263
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

61853:GIMAP2
gene id: 61853:GIMAP2
uniprot id: G1QUK9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61853:LOC100602087
gene id: 61853:LOC100602087
uniprot id: G1S9V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:GPD1
gene id: 61853:GPD1
uniprot id: G1S7Y5
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

61853:KRR1
gene id: 61853:KRR1
uniprot id: G1QXI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

61853:HMGCS2
gene id: 61853:HMGCS2
uniprot id: A0A2I3HU63
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

61853:PPP4R2
gene id: 61853:PPP4R2
uniprot id: A0A2I3HP16
names: Similarity
messages: Belongs to the PPP4R2 family.

61853:CAVIN2
gene id: 61853:CAVIN2
uniprot id: G1R4X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

61853:MOS
gene id: 61853:MOS
uniprot id: G1S9U6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:LOC100590776
gene id: 61853:LOC100590776
uniprot id: A0A2I3H0B9
names: Similarity
messages: Belongs to the TACO1 family.

61853:INTS12
gene id: 61853:INTS12
uniprot id: G1RRS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

61853:TLR7
gene id: 61853:TLR7
uniprot id: G1RD05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61853:PPARG
gene id: 61853:PPARG
uniprot id: A0A2I3H0K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

61853:PTX3
gene id: 61853:PTX3
uniprot id: G1QVJ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:GJB3
gene id: 61853:GJB3
uniprot id: A0A654ICW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:TPI1
gene id: 61853:TPI1
uniprot id: G1QY88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

61853:DZIP3
gene id: 61853:DZIP3
uniprot id: G1QUZ2
names: Subcellular Location Annotation
messages: Cytoplasm

61853:DNAL4
gene id: 61853:DNAL4
uniprot id: G1RYX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

61853:SAP130
gene id: 61853:SAP130
uniprot id: A0A2I3FVT6
uniprot id: G1S158
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

61853:EN2
gene id: 61853:EN2
uniprot id: G1RZJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

61853:ATRAID
gene id: 61853:ATRAID
uniprot id: G1QS17
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LUM
gene id: 61853:LUM
uniprot id: G1R0P4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

61853:KCNA10
gene id: 61853:KCNA10
uniprot id: G1S9E3
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100600266
gene id: 61853:LOC100600266
uniprot id: A0A2I3GM88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

61853:VTA1
gene id: 61853:VTA1
uniprot id: G1RYH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

61853:NUP93
gene id: 61853:NUP93
uniprot id: G1QPW6
uniprot id: M3ZCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

61853:PTGES2
gene id: 61853:PTGES2
uniprot id: G1S6Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

61853:SLC1A3
gene id: 61853:SLC1A3
uniprot id: A0A2I3HK04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

61853:LRP10
gene id: 61853:LRP10
uniprot id: G1RXJ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:NDNF
gene id: 61853:NDNF
uniprot id: A0A2I3H8G6
names: Subcellular Location Annotation
messages: Secreted

61853:NKG7
gene id: 61853:NKG7
uniprot id: A0A2I3GN47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

61853:INHBC
gene id: 61853:INHBC
uniprot id: G1S6B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

61853:TAS2R40
gene id: 61853:TAS2R40
uniprot id: G1S9X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61853:ARSL
gene id: 61853:ARSL
uniprot id: A0A2I3GNJ5
uniprot id: G1RAW9
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61853:DIPK2A
gene id: 61853:DIPK2A
uniprot id: G1QYR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

61853:MB21D2
gene id: 61853:MB21D2
uniprot id: A0A2I3HWL1
names: Similarity
messages: Belongs to the mab-21 family.

61853:COQ6
gene id: 61853:COQ6
uniprot id: G1S245
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

61853:LOC100603248
gene id: 61853:LOC100603248
uniprot id: G1SCB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:HMGCR
gene id: 61853:HMGCR
uniprot id: G1QZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

61853:MKRN2
gene id: 61853:MKRN2
uniprot id: G1QXQ5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:TPH2
gene id: 61853:TPH2
uniprot id: G1QWY3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

61853:LOC100587604
gene id: 61853:LOC100587604
uniprot id: M3ZBN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61853:KHDC4
gene id: 61853:KHDC4
uniprot id: G1RNS1
names: Similarity
messages: Belongs to the KHDC4 family.

61853:XRCC5
gene id: 61853:XRCC5
uniprot id: G1R6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

61853:POP5
gene id: 61853:POP5
uniprot id: G1S126
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

61853:FOXO4
gene id: 61853:FOXO4
uniprot id: A0A2I3H4R2
names: Subcellular Location Annotation
messages: Nucleus

61853:MYLK2
gene id: 61853:MYLK2
uniprot id: G1REZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

61853:LIX1
gene id: 61853:LIX1
uniprot id: G1RWH1
names: Similarity
messages: Belongs to the LIX1 family.

61853:SPRR2B
gene id: 61853:SPRR2B
uniprot id: A0A2I3GJR7
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61853:GBE1
gene id: 61853:GBE1
uniprot id: A0A2I3GDY3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

61853:GPX8
gene id: 61853:GPX8
uniprot id: A0A2I3FPU6
uniprot id: G1QKJ2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

61853:LPL
gene id: 61853:LPL
uniprot id: G1QT41
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

61853:ST3GAL6
gene id: 61853:ST3GAL6
uniprot id: G1QPF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:GDI2
gene id: 61853:GDI2
uniprot id: A0A2I3GNY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

61853:PTGER3
gene id: 61853:PTGER3
uniprot id: A0A2I3GL65
uniprot id: A0A2I3HLL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:USP4
gene id: 61853:USP4
uniprot id: G1R549
uniprot id: M3ZB69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

61853:TMEFF2
gene id: 61853:TMEFF2
uniprot id: A0A2I3HZ07
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TAMM41
gene id: 61853:TAMM41
uniprot id: A0A2I3GLS3
uniprot id: G1QX72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

61853:ANXA3
gene id: 61853:ANXA3
uniprot id: G1RAG3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61853:IMMP2L
gene id: 61853:IMMP2L
uniprot id: A0A2I3G9X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Membrane
messages: Mitochondrion inner membrane

61853:LOC115830347
gene id: 61853:LOC115830347
uniprot id: A0A2I3G9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

61853:MPC1L
gene id: 61853:MPC1L
uniprot id: G1SBK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61853:KCNV2
gene id: 61853:KCNV2
uniprot id: G1RBL7
names: Subcellular Location Annotation
messages: Membrane

61853:MPHOSPH10
gene id: 61853:MPHOSPH10
uniprot id: G1RH15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

61853:HSD17B13
gene id: 61853:HSD17B13
uniprot id: A0A2I3GHP1
uniprot id: G1REA2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:CLASP1
gene id: 61853:CLASP1
uniprot id: A0A2I3FU57
uniprot id: G1QKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: centrosome
messages: kinetochore
messages: trans-Golgi network

61853:NSUN2
gene id: 61853:NSUN2
uniprot id: G1RKW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

61853:CHURC1
gene id: 61853:CHURC1
uniprot id: A0A2I3GPA9
uniprot id: A0A2I3HWK9
names: Similarity
messages: Belongs to the Churchill family.

61853:IL1RAP
gene id: 61853:IL1RAP
uniprot id: A0A2I3HX22
uniprot id: G1R4V0
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61853:NDUFA6
gene id: 61853:NDUFA6
uniprot id: G1S0Z0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:SERPINC1
gene id: 61853:SERPINC1
uniprot id: G1RZC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the serpin family.
messages: Forms protease inhibiting heterodimer with TMPRSS7.
messages: extracellular space

61853:TRIT1
gene id: 61853:TRIT1
uniprot id: G1RN30
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

61853:PYCARD
gene id: 61853:PYCARD
uniprot id: G1S2K3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

61853:LOC100591680
gene id: 61853:LOC100591680
uniprot id: G1RCK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

61853:MPO
gene id: 61853:MPO
uniprot id: G1R9P6
names: Cofactor
messages: Binds 1 Ca(2+) ion per monomer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.

61853:ATP11C
gene id: 61853:ATP11C
uniprot id: A0A2I3G4I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

61853:LSM14A
gene id: 61853:LSM14A
uniprot id: A0A2I3GF12
uniprot id: G1RM06
names: Similarity
messages: Belongs to the LSM14 family.

61853:LCA5
gene id: 61853:LCA5
uniprot id: G1RP79
names: Similarity
messages: Belongs to the LCA5 family.

61853:YIF1A
gene id: 61853:YIF1A
uniprot id: A0A2I3GEJ2
uniprot id: G1R2D0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SEC62
gene id: 61853:SEC62
uniprot id: G1QZ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:MYOZ2
gene id: 61853:MYOZ2
uniprot id: G1RCM5
names: Similarity
messages: Belongs to the myozenin family.

61853:GALNTL6
gene id: 61853:GALNTL6
uniprot id: A0A2I3HSY4
uniprot id: G1R4G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:CAPZA3
gene id: 61853:CAPZA3
uniprot id: G1SA78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

61853:CD79B
gene id: 61853:CD79B
uniprot id: A0A2I3G367
uniprot id: G1RYQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:RPLP1
gene id: 61853:RPLP1
uniprot id: A0A2I3G4D8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

61853:PSMC5
gene id: 61853:PSMC5
uniprot id: G1QVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

61853:SSRP1
gene id: 61853:SSRP1
uniprot id: G1RPY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

61853:TNFSF4
gene id: 61853:TNFSF4
uniprot id: G1RZ60
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61853:COPS7A
gene id: 61853:COPS7A
uniprot id: G1QX83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

61853:ERAL1
gene id: 61853:ERAL1
uniprot id: G1QS33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

61853:C6H15orf40
gene id: 61853:C6H15orf40
uniprot id: A0A2I3GAC6
names: Similarity
messages: Belongs to the UPF0235 family.

61853:ADGRV1
gene id: 61853:ADGRV1
uniprot id: G1RUC6
names: Subcellular Location Annotation
messages: Membrane

61853:CNOT9
gene id: 61853:CNOT9
uniprot id: A0A2I3HXU2
uniprot id: G1RBS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

61853:NRG3
gene id: 61853:NRG3
uniprot id: A0A2I3HNB1
uniprot id: A0A2I3HTB7
names: Caution
names: Similarity
messages: Belongs to the neuregulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:KRT72
gene id: 61853:KRT72
uniprot id: A0A2I3H7M8
uniprot id: G1S7Q2
names: Similarity
messages: Belongs to the intermediate filament family.

61853:ACOX2
gene id: 61853:ACOX2
uniprot id: G1R6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61853:CLDN4
gene id: 61853:CLDN4
uniprot id: G1SAN1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:ATP8B1
gene id: 61853:ATP8B1
uniprot id: G1R9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

61853:ICMT
gene id: 61853:ICMT
uniprot id: A0A2I3FXC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:LOC100595735
gene id: 61853:LOC100595735
uniprot id: A0A2I3H3D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

61853:GNS
gene id: 61853:GNS
uniprot id: A0A2I3HGX1
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61853:APOOL
gene id: 61853:APOOL
uniprot id: G1QQH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

61853:GSTO1
gene id: 61853:GSTO1
uniprot id: G1RZH2
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

61853:HTRA2
gene id: 61853:HTRA2
uniprot id: A0A2I3H871
names: Similarity
messages: Belongs to the peptidase S1C family.

61853:PROKR1
gene id: 61853:PROKR1
uniprot id: G1RG68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:UFM1
gene id: 61853:UFM1
uniprot id: G1QQ89
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

61853:CHRM5
gene id: 61853:CHRM5
uniprot id: G1SBZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

61853:GABRR1
gene id: 61853:GABRR1
uniprot id: A0A2I3GI15
uniprot id: A0A2I3GMK6
uniprot id: G1RRN1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:WNT16
gene id: 61853:WNT16
uniprot id: A0A2I3GPV0
uniprot id: G1RMK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:NXF3
gene id: 61853:NXF3
uniprot id: G1R7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

61853:ITGB6
gene id: 61853:ITGB6
uniprot id: A0A2I3G233
uniprot id: A0A2I3GWK8
uniprot id: G1QM06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61853:LOC100590761
gene id: 61853:LOC100590761
uniprot id: A0A2I3G353
uniprot id: A0A2I3GYN4
uniprot id: A0A2I3GZY8
uniprot id: A0A2I3H7X2
uniprot id: A0A2I3HCM0
uniprot id: A0A2I3HYW1
uniprot id: G1SA29
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

61853:OLFML3
gene id: 61853:OLFML3
uniprot id: A0A2I3HTP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:TMEM184B
gene id: 61853:TMEM184B
uniprot id: G1RYJ7
names: Subcellular Location Annotation
messages: Membrane

61853:WRNIP1
gene id: 61853:WRNIP1
uniprot id: G1RJ84
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

61853:CYGB
gene id: 61853:CYGB
uniprot id: A0A2I3GBD3
names: Similarity
messages: Belongs to the globin family.

61853:SF3B1
gene id: 61853:SF3B1
uniprot id: A0A2I3GPD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

61853:FAM126B
gene id: 61853:FAM126B
uniprot id: G1R5J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

61853:NSUN7
gene id: 61853:NSUN7
uniprot id: A0A2I3FZR0
uniprot id: G1S5Q7
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:DDX49
gene id: 61853:DDX49
uniprot id: G1R2N8
names: Similarity
messages: Belongs to the DEAD box helicase family.

61853:FTMT
gene id: 61853:FTMT
uniprot id: G1SB68
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61853:HIBADH
gene id: 61853:HIBADH
uniprot id: G1RYC1
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

61853:POLR3F
gene id: 61853:POLR3F
uniprot id: G1RFC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61853:GDF3
gene id: 61853:GDF3
uniprot id: G1QZV2
names: Similarity
messages: Belongs to the TGF-beta family.

61853:HTR1B
gene id: 61853:HTR1B
uniprot id: G1S9T8
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

61853:B4GALT4
gene id: 61853:B4GALT4
uniprot id: G1QY60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61853:SPHKAP
gene id: 61853:SPHKAP
uniprot id: A0A2I3HG14
uniprot id: G1RT80
names: Similarity
messages: Belongs to the AKAP110 family.

61853:B4GALT6
gene id: 61853:B4GALT6
uniprot id: G1R3S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61853:CENPN
gene id: 61853:CENPN
uniprot id: A0A2I3GLH8
uniprot id: A0A2I3GV52
uniprot id: A0A2I3H9C9
uniprot id: A0A2I3HGT8
uniprot id: G1RHM3
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

61853:HIF1A
gene id: 61853:HIF1A
uniprot id: A0A2I3HYP2
uniprot id: G1RUP5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle

61853:SUPT16H
gene id: 61853:SUPT16H
uniprot id: G1RWD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

61853:TNFRSF1A
gene id: 61853:TNFRSF1A
uniprot id: A0A2I3GEI2
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:LOC100601771
gene id: 61853:LOC100601771
uniprot id: G1R4L8
names: Similarity
messages: Belongs to the MHC class II family.

61853:RXRG
gene id: 61853:RXRG
uniprot id: G1RX84
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

61853:ACKR3
gene id: 61853:ACKR3
uniprot id: G1RIE0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:ARRB1
gene id: 61853:ARRB1
uniprot id: G1S4Y2
names: Similarity
messages: Belongs to the arrestin family.

61853:PPP4R3A
gene id: 61853:PPP4R3A
uniprot id: G1S5G6
names: Similarity
messages: Belongs to the SMEK family.

61853:MED21
gene id: 61853:MED21
uniprot id: A0A2I3G1U2
uniprot id: G1R051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61853:ELAVL2
gene id: 61853:ELAVL2
uniprot id: G1S300
names: Similarity
messages: Belongs to the RRM elav family.

61853:LOC100579854
gene id: 61853:LOC100579854
uniprot id: A0A2I3HFH2
uniprot id: G1RPN9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer with ADAM1/fertilin subunit alpha.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

61853:AK5
gene id: 61853:AK5
uniprot id: A0A2I3HD70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family.
messages: Cytoplasm

61853:ATAD2
gene id: 61853:ATAD2
uniprot id: G1QZR9
names: Similarity
messages: Belongs to the AAA ATPase family.

61853:GABRG2
gene id: 61853:GABRG2
uniprot id: A0A2I3H5Q7
uniprot id: G1QXE0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:GABARAPL2
gene id: 61853:GABARAPL2
uniprot id: A0A2I3GXJ2
names: Similarity
messages: Belongs to the ATG8 family.

61853:MRPL28
gene id: 61853:MRPL28
uniprot id: A0A2I3GSU5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

61853:SUFU
gene id: 61853:SUFU
uniprot id: A0A2I3HVV4
uniprot id: G1RYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

61853:LOC100591010
gene id: 61853:LOC100591010
uniprot id: G1RCJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

61853:SLC30A8
gene id: 61853:SLC30A8
uniprot id: A0A2I3H8R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

61853:PARP8
gene id: 61853:PARP8
uniprot id: A0A2I3HMT3
names: Similarity
messages: Belongs to the ARTD/PARP family.

61853:GBX1
gene id: 61853:GBX1
uniprot id: G1QW66
names: Subcellular Location Annotation
messages: Nucleus

61853:DYNC1I2
gene id: 61853:DYNC1I2
uniprot id: A0A2I3FRB4
uniprot id: A0A2I3GGY1
names: Similarity
messages: Belongs to the dynein intermediate chain family.

61853:PRR15
gene id: 61853:PRR15
uniprot id: A0A2I3G8A8
names: Similarity
messages: Belongs to the PRR15 family.

61853:CEP162
gene id: 61853:CEP162
uniprot id: A0A2I3HYL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP162 family.
messages: centriole

61853:NUP35
gene id: 61853:NUP35
uniprot id: A0A2I3FX38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

61853:TCTE3
gene id: 61853:TCTE3
uniprot id: G1QH97
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61853:RPE
gene id: 61853:RPE
uniprot id: A0A2I3HGS3
uniprot id: A0A2I3HSC9
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

61853:RPS6KA1
gene id: 61853:RPS6KA1
uniprot id: A0A2I3G2C2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61853:UBE4A
gene id: 61853:UBE4A
uniprot id: G1R708
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

61853:RXRB
gene id: 61853:RXRB
uniprot id: G1R516
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

61853:NOS2
gene id: 61853:NOS2
uniprot id: G1QMC7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

61853:SMPDL3B
gene id: 61853:SMPDL3B
uniprot id: G1RF21
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

61853:ST6GAL1
gene id: 61853:ST6GAL1
uniprot id: G1R4K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:TM6SF1
gene id: 61853:TM6SF1
uniprot id: G1RJ34
names: Subcellular Location Annotation
messages: Membrane

61853:PRKACB
gene id: 61853:PRKACB
uniprot id: A0A2I3G8D7
uniprot id: A0A2I3GCI8
uniprot id: A0A2I3GYG9
uniprot id: A0A2I3H8D0
uniprot id: G1RFR2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

61853:LOC100603183
gene id: 61853:LOC100603183
uniprot id: G1S9T1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:YKT6
gene id: 61853:YKT6
uniprot id: G1QU42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

61853:PARP11
gene id: 61853:PARP11
uniprot id: A0A2I3GCT8
uniprot id: A0A2I3H8T0
names: Similarity
messages: Belongs to the ARTD/PARP family.

61853:ORMDL1
gene id: 61853:ORMDL1
uniprot id: G1R4D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

61853:CXCL3
gene id: 61853:CXCL3
uniprot id: G1R8Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:NUDT5
gene id: 61853:NUDT5
uniprot id: A0A2I3HME7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

61853:SLITRK4
gene id: 61853:SLITRK4
uniprot id: A0A2I3HJG8
names: Similarity
messages: Belongs to the SLITRK family.

61853:LOC100592640
gene id: 61853:LOC100592640
uniprot id: A0A2I3H8R1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:FH
gene id: 61853:FH
uniprot id: A0A2I3G9T5
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

61853:KCNE2
gene id: 61853:KCNE2
uniprot id: A0A2I3GYX8
names: Similarity
messages: Belongs to the potassium channel KCNE family.

61853:CASP5
gene id: 61853:CASP5
uniprot id: A0A2I3GJI8
uniprot id: A0A2I3HII9
uniprot id: G1R6F9
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:RPF2
gene id: 61853:RPF2
uniprot id: A0A2I3HLG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

61853:TBXAS1
gene id: 61853:TBXAS1
uniprot id: A0A2I3HV47
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:NUBP1
gene id: 61853:NUBP1
uniprot id: A0A2I3HQY7
uniprot id: G1RGK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

61853:PANX3
gene id: 61853:PANX3
uniprot id: G1R777
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

61853:PLD2
gene id: 61853:PLD2
uniprot id: G1S6J5
names: Similarity
messages: Belongs to the phospholipase D family.

61853:ELOC
gene id: 61853:ELOC
uniprot id: A0A2I3GHI4
names: Similarity
messages: Belongs to the SKP1 family.

61853:ACTBL2
gene id: 61853:ACTBL2
uniprot id: G1S9C9
names: Similarity
messages: Belongs to the actin family.

61853:ATP6V1C1
gene id: 61853:ATP6V1C1
uniprot id: G1QU60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

61853:KCNJ1
gene id: 61853:KCNJ1
uniprot id: G1R7D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61853:SLC25A31
gene id: 61853:SLC25A31
uniprot id: G1RT90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

61853:GRPR
gene id: 61853:GRPR
uniprot id: G1REB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:NKD1
gene id: 61853:NKD1
uniprot id: A0A2I3H1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61853:MSX1
gene id: 61853:MSX1
uniprot id: G1S212
names: Subcellular Location Annotation
messages: Nucleus

61853:PTH2R
gene id: 61853:PTH2R
uniprot id: A0A2I3GJZ9
names: Subcellular Location Annotation
messages: Membrane

61853:ENY2
gene id: 61853:ENY2
uniprot id: A0A2I3GR30
uniprot id: G1QW82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

61853:AASS
gene id: 61853:AASS
uniprot id: G1RMY3
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

61853:TIMM21
gene id: 61853:TIMM21
uniprot id: A0A2I3GTR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane
messages: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes.

61853:LOC100601888
gene id: 61853:LOC100601888
uniprot id: G1S969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ANP32A
gene id: 61853:ANP32A
uniprot id: G1RSJ4
names: Similarity
messages: Belongs to the ANP32 family.

61853:LOC100582185
gene id: 61853:LOC100582185
uniprot id: G1SC00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:MACO1
gene id: 61853:MACO1
uniprot id: G1RCW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

61853:ACKR4
gene id: 61853:ACKR4
uniprot id: G1QT16
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:TOR3A
gene id: 61853:TOR3A
uniprot id: G1S088
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

61853:LOC100604573
gene id: 61853:LOC100604573
uniprot id: G1RCQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Interacts with YBX1.
messages: Mitochondrion
messages: Nucleus

61853:PPP1R10
gene id: 61853:PPP1R10
uniprot id: G1QZD7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

61853:SPDEF
gene id: 61853:SPDEF
uniprot id: A0A2I3H7Y4
uniprot id: G1RAF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:UTP25
gene id: 61853:UTP25
uniprot id: G1QNG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

61853:STAM
gene id: 61853:STAM
uniprot id: A0A2I3HS36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

61853:ACP5
gene id: 61853:ACP5
uniprot id: G1RQ24
names: Cofactor
messages: Binds 2 iron ions per subunit.

61853:DAD1
gene id: 61853:DAD1
uniprot id: G1RX68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

61853:DLST
gene id: 61853:DLST
uniprot id: G1S2U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61853:PLCB3
gene id: 61853:PLCB3
uniprot id: G1QYG5
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

61853:DDX54
gene id: 61853:DDX54
uniprot id: G1QH06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

61853:OOEP
gene id: 61853:OOEP
uniprot id: G1QKI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDC1 family.
messages: Cytoplasm
messages: Nucleus

61853:HSPA5
gene id: 61853:HSPA5
uniprot id: G1S6C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

61853:ATG16L2
gene id: 61853:ATG16L2
uniprot id: A0A2I3HC25
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

61853:DERL1
gene id: 61853:DERL1
uniprot id: G1QZD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

61853:CRYZ
gene id: 61853:CRYZ
uniprot id: A0A2I3GPF1
uniprot id: G1REH3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61853:GPBP1
gene id: 61853:GPBP1
uniprot id: G1QPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

61853:DACT1
gene id: 61853:DACT1
uniprot id: G1RSK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dapper family.
messages: Cytoplasm

61853:DUSP13
gene id: 61853:DUSP13
uniprot id: A0A2I3G366
uniprot id: G1S4N2
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61853:TIMM17A
gene id: 61853:TIMM17A
uniprot id: A0A2I3H6L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

61853:TGM4
gene id: 61853:TGM4
uniprot id: G1R263
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61853:BCL7C
gene id: 61853:BCL7C
uniprot id: A0A2I3HB39
uniprot id: G1S1S2
names: Similarity
messages: Belongs to the BCL7 family.

61853:UCN
gene id: 61853:UCN
uniprot id: G1QSL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

61853:ADGRF4
gene id: 61853:ADGRF4
uniprot id: G1QVZ8
names: Subcellular Location Annotation
messages: Membrane

61853:MBOAT7
gene id: 61853:MBOAT7
uniprot id: G1R392
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100589938
gene id: 61853:LOC100589938
uniprot id: G1RX19
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:AGTR2
gene id: 61853:AGTR2
uniprot id: A0A2I3GVK7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

61853:CRY1
gene id: 61853:CRY1
uniprot id: G1R4R9
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

61853:EMP1
gene id: 61853:EMP1
uniprot id: G1QUA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

61853:VPS13A
gene id: 61853:VPS13A
uniprot id: A0A2I3GA42
uniprot id: A0A2I3H2P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

61853:OASL
gene id: 61853:OASL
uniprot id: A0A2I3GG94
uniprot id: A0A2I3GQA6
uniprot id: A0A2I3HP07
names: Similarity
messages: Belongs to the 2-5A synthase family.

61853:MSH2
gene id: 61853:MSH2
uniprot id: M3ZAA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

61853:LBP
gene id: 61853:LBP
uniprot id: G1R3G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

61853:AP3S1
gene id: 61853:AP3S1
uniprot id: A0A2I3GWB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

61853:FUCA2
gene id: 61853:FUCA2
uniprot id: G1RYM4
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

61853:ARHGDIB
gene id: 61853:ARHGDIB
uniprot id: G1QV75
names: Similarity
messages: Belongs to the Rho GDI family.

61853:PKD2L2
gene id: 61853:PKD2L2
uniprot id: G1RB69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Membrane

61853:LIN7B
gene id: 61853:LIN7B
uniprot id: G1QYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

61853:TRIM36
gene id: 61853:TRIM36
uniprot id: A0A2I3GL73
uniprot id: G1RLZ8
names: Subcellular Location Annotation
messages: cytoskeleton

61853:TNP2
gene id: 61853:TNP2
uniprot id: G1SA05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

61853:HMGN3
gene id: 61853:HMGN3
uniprot id: A0A2I3GLP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
messages: Nucleus

61853:LOC100600510
gene id: 61853:LOC100600510
uniprot id: G1RKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61853:MMP25
gene id: 61853:MMP25
uniprot id: G1REM2
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:CCNA1
gene id: 61853:CCNA1
uniprot id: G1S0F4
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

61853:MSX2
gene id: 61853:MSX2
uniprot id: G1QI88
names: Subcellular Location Annotation
messages: Nucleus

61853:GOLPH3L
gene id: 61853:GOLPH3L
uniprot id: A0A2I3H4Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

61853:RHO
gene id: 61853:RHO
uniprot id: G1QZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

61853:KCNQ3
gene id: 61853:KCNQ3
uniprot id: A0A2I3HPQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:PSMB7
gene id: 61853:PSMB7
uniprot id: A0A2I3HSC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

61853:PPP6C
gene id: 61853:PPP6C
uniprot id: G1S6A3
names: Similarity
messages: Belongs to the PPP phosphatase family.

61853:DCT
gene id: 61853:DCT
uniprot id: A0A2I3HTD7
uniprot id: G1S3C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

61853:ADGRF5
gene id: 61853:ADGRF5
uniprot id: G1QWL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

61853:DEGS1
gene id: 61853:DEGS1
uniprot id: G1RSN5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane
messages: Mitochondrion membrane

61853:RCAN2
gene id: 61853:RCAN2
uniprot id: A0A2I3HBN8
uniprot id: G1QX80
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

61853:ZNF394
gene id: 61853:ZNF394
uniprot id: A0A2I3GIN9
names: Subcellular Location Annotation
messages: Nucleus

61853:HDAC3
gene id: 61853:HDAC3
uniprot id: G1REQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

61853:ADGRG7
gene id: 61853:ADGRG7
uniprot id: A0A2I3G6N9
uniprot id: G1QR81
names: Subcellular Location Annotation
messages: Membrane

61853:ARRDC3
gene id: 61853:ARRDC3
uniprot id: G1RUE0
names: Similarity
messages: Belongs to the arrestin family.

61853:E2F4
gene id: 61853:E2F4
uniprot id: G1QWE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61853:SEC24D
gene id: 61853:SEC24D
uniprot id: G1RCH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61853:SULT6B1
gene id: 61853:SULT6B1
uniprot id: G1S2D4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:MRPL41
gene id: 61853:MRPL41
uniprot id: G1RDE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

61853:DPYS
gene id: 61853:DPYS
uniprot id: G1QUV8
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

61853:UFD1
gene id: 61853:UFD1
uniprot id: G1R032
names: Similarity
messages: Belongs to the UFD1 family.

61853:VSX2
gene id: 61853:VSX2
uniprot id: G1S2B2
names: Subcellular Location Annotation
messages: Nucleus

61853:MC4R
gene id: 61853:MC4R
uniprot id: G1SA07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

61853:SF3A1
gene id: 61853:SF3A1
uniprot id: G1QU96
names: Subcellular Location Annotation
messages: Nucleus

61853:TYW3
gene id: 61853:TYW3
uniprot id: A0A2I3GK38
uniprot id: G1REI8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

61853:ATP11B
gene id: 61853:ATP11B
uniprot id: G1R210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

61853:GALR2
gene id: 61853:GALR2
uniprot id: G1QNH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:ZSCAN18
gene id: 61853:ZSCAN18
uniprot id: A0A2I3HAM6
names: Subcellular Location Annotation
messages: Nucleus

61853:TBX20
gene id: 61853:TBX20
uniprot id: G1QLX5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:SLC5A4
gene id: 61853:SLC5A4
uniprot id: G1RVE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61853:EXOG
gene id: 61853:EXOG
uniprot id: A0A2I3GX86
uniprot id: G1R046
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

61853:MTERF3
gene id: 61853:MTERF3
uniprot id: G1QTT7
names: Similarity
messages: Belongs to the mTERF family.

61853:NKAIN2
gene id: 61853:NKAIN2
uniprot id: A0A2I3H4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

61853:MUS81
gene id: 61853:MUS81
uniprot id: G1R1P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

61853:PIK3CG
gene id: 61853:PIK3CG
uniprot id: G1RC26
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61853:RAD21L1
gene id: 61853:RAD21L1
uniprot id: A0A2I3HZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

61853:FGF23
gene id: 61853:FGF23
uniprot id: G1QS31
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:SLITRK5
gene id: 61853:SLITRK5
uniprot id: G1S3A4
names: Similarity
messages: Belongs to the SLITRK family.

61853:RAB5IF
gene id: 61853:RAB5IF
uniprot id: A0A2I3HCU9
names: Subcellular Location Annotation
messages: Membrane

61853:GTF2A1
gene id: 61853:GTF2A1
uniprot id: A0A2I3GQX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

61853:RET
gene id: 61853:RET
uniprot id: G1S142
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

61853:KIAA1324L
gene id: 61853:KIAA1324L
uniprot id: G1RY17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

61853:GADD45A
gene id: 61853:GADD45A
uniprot id: G1RDG6
names: Similarity
messages: Belongs to the GADD45 family.

61853:EIF3L
gene id: 61853:EIF3L
uniprot id: G1RY73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

61853:MRGPRX2
gene id: 61853:MRGPRX2
uniprot id: W8W3J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

61853:SNAP91
gene id: 61853:SNAP91
uniprot id: A0A2I3H6N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

61853:DEFB121
gene id: 61853:DEFB121
uniprot id: G1REJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:MANEAL
gene id: 61853:MANEAL
uniprot id: G1RLR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 99 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:H1-3
gene id: 61853:H1-3
uniprot id: G1S9R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61853:LOC100606185
gene id: 61853:LOC100606185
uniprot id: G1SBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:KNG1
gene id: 61853:KNG1
uniprot id: A0A2I3GVD0
uniprot id: A0A2I3HH60
uniprot id: G1R4E4
names: Subcellular Location Annotation
messages: extracellular space

61853:NOX1
gene id: 61853:NOX1
uniprot id: A0A2I3H8U0
uniprot id: A0A2I3HAL5
uniprot id: G1R7G9
names: Subcellular Location Annotation
messages: Membrane

61853:HPRT1
gene id: 61853:HPRT1
uniprot id: G1QNB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

61853:GUF1
gene id: 61853:GUF1
uniprot id: A0A2I3HIV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

61853:SOST
gene id: 61853:SOST
uniprot id: G1R143
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

61853:TRAPPC1
gene id: 61853:TRAPPC1
uniprot id: G1RFD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

61853:N6AMT1
gene id: 61853:N6AMT1
uniprot id: G1QRA3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

61853:HSD17B10
gene id: 61853:HSD17B10
uniprot id: G1S1N0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:MMP1
gene id: 61853:MMP1
uniprot id: G1R6C9
names: Similarity
messages: Belongs to the peptidase M10A family.

61853:ANKS1B
gene id: 61853:ANKS1B
uniprot id: G1R2K3
names: Subcellular Location Annotation
messages: Cytoplasm

61853:PLCB1
gene id: 61853:PLCB1
uniprot id: A0A2I3HFW9
uniprot id: G1RVN2
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

61853:TMEM70
gene id: 61853:TMEM70
uniprot id: A0A2I3GSW6
names: Similarity
messages: Belongs to the TMEM70 family.

61853:CX3CL1
gene id: 61853:CX3CL1
uniprot id: G1QRA5
names: Subcellular Location Annotation
messages: Secreted

61853:GPR18
gene id: 61853:GPR18
uniprot id: G1R945
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

61853:PDF
gene id: 61853:PDF
uniprot id: G1R0B4
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins.

61853:DNAH10
gene id: 61853:DNAH10
uniprot id: G1QPB5
names: Similarity
messages: Belongs to the dynein heavy chain family.

61853:LOC100579903
gene id: 61853:LOC100579903
uniprot id: A0A2I3HJM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61853:SPPL2A
gene id: 61853:SPPL2A
uniprot id: G1R3C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

61853:AK2
gene id: 61853:AK2
uniprot id: A0A2I3GCV1
uniprot id: G1QSG9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

61853:SELP
gene id: 61853:SELP
uniprot id: G1RYC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:DENND6A
gene id: 61853:DENND6A
uniprot id: M3ZBR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND6 family.
messages: Endosome
messages: Recycling endosome

61853:ALG2
gene id: 61853:ALG2
uniprot id: G1S5C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

61853:LOC100598307
gene id: 61853:LOC100598307
uniprot id: A0A7R8GUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:LDB2
gene id: 61853:LDB2
uniprot id: A0A2I3H4Z2
names: Similarity
messages: Belongs to the LDB family.

61853:LOC100604697
gene id: 61853:LOC100604697
uniprot id: G1QX67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

61853:CFL2
gene id: 61853:CFL2
uniprot id: G1QT84
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

61853:DEFB135
gene id: 61853:DEFB135
uniprot id: G1RYL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:NEMP1
gene id: 61853:NEMP1
uniprot id: G1S6L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

61853:HEATR5B
gene id: 61853:HEATR5B
uniprot id: G1S295
names: Similarity
messages: Belongs to the HEATR5 family.

61853:WAS
gene id: 61853:WAS
uniprot id: G1R8P1
names: Subcellular Location Annotation
messages: Nucleus

61853:AGA
gene id: 61853:AGA
uniprot id: G1S4J8
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

61853:GFM1
gene id: 61853:GFM1
uniprot id: G1QVZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

61853:CNOT7
gene id: 61853:CNOT7
uniprot id: G1QQ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

61853:ETS1
gene id: 61853:ETS1
uniprot id: A0A2I3HRB8
uniprot id: G1R7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

61853:NGB
gene id: 61853:NGB
uniprot id: G1S403
names: Similarity
messages: Belongs to the globin family.

61853:SCAMP3
gene id: 61853:SCAMP3
uniprot id: A0A2I3HVB4
uniprot id: G1RN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

61853:CCL26
gene id: 61853:CCL26
uniprot id: G1RB74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61853:TTC27
gene id: 61853:TTC27
uniprot id: G1S1A0
names: Similarity
messages: Belongs to the TTC27 family.

61853:KDM4C
gene id: 61853:KDM4C
uniprot id: M3Z927
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

61853:SNX3
gene id: 61853:SNX3
uniprot id: A0A2I3GBF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

61853:MFSD9
gene id: 61853:MFSD9
uniprot id: G1RXB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61853:TMEM251
gene id: 61853:TMEM251
uniprot id: A0A2I3HY88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

61853:LOC100603119
gene id: 61853:LOC100603119
uniprot id: A0A2I3HT40
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

61853:SLC25A20
gene id: 61853:SLC25A20
uniprot id: A0A2I3H4B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:MFSD14B
gene id: 61853:MFSD14B
uniprot id: G1S3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61853:PAH
gene id: 61853:PAH
uniprot id: G1R3M2
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

61853:MKX
gene id: 61853:MKX
uniprot id: G1S535
names: Subcellular Location Annotation
messages: Nucleus

61853:GNGT1
gene id: 61853:GNGT1
uniprot id: G1RZQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61853:ZSCAN30
gene id: 61853:ZSCAN30
uniprot id: A0A2I3HVL0
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100586578
gene id: 61853:LOC100586578
uniprot id: A0A2I3GB94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61853:LOC100582240
gene id: 61853:LOC100582240
uniprot id: G1RNH5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

61853:KYAT3
gene id: 61853:KYAT3
uniprot id: G1RGW7
names: Subunit
messages: Homodimer.

61853:PTMA
gene id: 61853:PTMA
uniprot id: G1RVF3
names: Similarity
messages: Belongs to the pro/parathymosin family.

61853:AMACR
gene id: 61853:AMACR
uniprot id: A0A2I3I058
uniprot id: G1RVY1
names: Similarity
messages: Belongs to the CoA-transferase III family.

61853:HEBP1
gene id: 61853:HEBP1
uniprot id: G1QU62
names: Similarity
messages: Belongs to the HEBP family.

61853:NEU1
gene id: 61853:NEU1
uniprot id: G1R3L8
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61853:TUBAL3
gene id: 61853:TUBAL3
uniprot id: G1RKQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61853:P2RX7
gene id: 61853:P2RX7
uniprot id: G1S1N3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61853:CPT2
gene id: 61853:CPT2
uniprot id: G1S8L6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61853:SIRT4
gene id: 61853:SIRT4
uniprot id: G1S0B4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

61853:ADPRHL2
gene id: 61853:ADPRHL2
uniprot id: G1RKG8
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

61853:PNPLA4
gene id: 61853:PNPLA4
uniprot id: G1RBC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CRYBB1
gene id: 61853:CRYBB1
uniprot id: A0A2I3G937
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

61853:SHTN1
gene id: 61853:SHTN1
uniprot id: A0A2I3GPB6
uniprot id: G1S3J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shootin family.
messages: axon
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

61853:ARL11
gene id: 61853:ARL11
uniprot id: A0A2I3FXD0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61853:PI4KA
gene id: 61853:PI4KA
uniprot id: G1QH25
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61853:CHRNA6
gene id: 61853:CHRNA6
uniprot id: A0A2I3FXS2
uniprot id: G1RR34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:PDCD5
gene id: 61853:PDCD5
uniprot id: A0A2I3GZM9
names: Similarity
messages: Belongs to the PDCD5 family.

61853:SH3BP5
gene id: 61853:SH3BP5
uniprot id: G1QM43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

61853:GAD1
gene id: 61853:GAD1
uniprot id: G1QZH4
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61853:CHM
gene id: 61853:CHM
uniprot id: G1QR06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

61853:CCT7
gene id: 61853:CCT7
uniprot id: G1RHW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

61853:PRKAR1A
gene id: 61853:PRKAR1A
uniprot id: A0A2I3HG51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61853:FGF20
gene id: 61853:FGF20
uniprot id: A0A2I3FZ33
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:ASB16
gene id: 61853:ASB16
uniprot id: G1R0F9
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:BHMT
gene id: 61853:BHMT
uniprot id: G1RQT1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

61853:FMO3
gene id: 61853:FMO3
uniprot id: G1RYS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

61853:HPDL
gene id: 61853:HPDL
uniprot id: G1S9L7
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

61853:EBF1
gene id: 61853:EBF1
uniprot id: A0A2I3HUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61853:PORCN
gene id: 61853:PORCN
uniprot id: A0A2I3GC52
uniprot id: G1R8I9
names: Subcellular Location Annotation
messages: Membrane

61853:OPN5
gene id: 61853:OPN5
uniprot id: G1QVX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:DRD3
gene id: 61853:DRD3
uniprot id: A0A2I3G112
uniprot id: G1QXU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
messages: Membrane

61853:PGAM1
gene id: 61853:PGAM1
uniprot id: G1RUA8
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61853:NKX6-1
gene id: 61853:NKX6-1
uniprot id: G1RD47
names: Subcellular Location Annotation
messages: Nucleus

61853:SLC7A1
gene id: 61853:SLC7A1
uniprot id: G1QIM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

61853:ANXA4
gene id: 61853:ANXA4
uniprot id: G1RGJ9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

61853:EXOSC4
gene id: 61853:EXOSC4
uniprot id: G1RHK5
names: Subcellular Location Annotation
messages: Cytoplasm

61853:GASK1B
gene id: 61853:GASK1B
uniprot id: A0A2I3G0W7
names: Similarity
messages: Belongs to the GASK family.

61853:IL37
gene id: 61853:IL37
uniprot id: A0A2I3H882
uniprot id: A0A2I3H9R0
uniprot id: A0A2I3HKJ9
uniprot id: G1QN29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61853:EHHADH
gene id: 61853:EHHADH
uniprot id: A0A2I3FVY2
uniprot id: G1R3S4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

61853:F9
gene id: 61853:F9
uniprot id: A0A2I3GYU4
uniprot id: G1QRY9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:RNF31
gene id: 61853:RNF31
uniprot id: G1RZ82
names: Similarity
messages: Belongs to the RBR family.

61853:VGLL4
gene id: 61853:VGLL4
uniprot id: A0A2I3HND5
uniprot id: G1QX51
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

61853:P2RY2
gene id: 61853:P2RY2
uniprot id: G1S5M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:TMEM167A
gene id: 61853:TMEM167A
uniprot id: G1RS06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

61853:GABRG3
gene id: 61853:GABRG3
uniprot id: G1RHV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:GNB4
gene id: 61853:GNB4
uniprot id: G1R1B0
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

61853:LOC100590665
gene id: 61853:LOC100590665
uniprot id: G1R675
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61853:NGRN
gene id: 61853:NGRN
uniprot id: G1RMW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

61853:BICC1
gene id: 61853:BICC1
uniprot id: G1RNV6
names: Similarity
messages: Belongs to the BicC family.

61853:C17H6orf89
gene id: 61853:C17H6orf89
uniprot id: A0A2I3FPD6
uniprot id: A0A2I3H3Y9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

61853:FUNDC1
gene id: 61853:FUNDC1
uniprot id: G1QQ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

61853:GDPGP1
gene id: 61853:GDPGP1
uniprot id: G1SB57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

61853:CPPED1
gene id: 61853:CPPED1
uniprot id: A0A2I3GBP0
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

61853:RNF114
gene id: 61853:RNF114
uniprot id: G1R5P2
names: Subunit
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

61853:MGST1
gene id: 61853:MGST1
uniprot id: G1QW63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

61853:LOC100599179
gene id: 61853:LOC100599179
uniprot id: G1RGZ2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61853:ENOPH1
gene id: 61853:ENOPH1
uniprot id: G1RBN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

61853:NFYB
gene id: 61853:NFYB
uniprot id: A0A2I3GML6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

61853:CCNQ
gene id: 61853:CCNQ
uniprot id: G1RSA2
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

61853:IAH1
gene id: 61853:IAH1
uniprot id: G1RSQ7
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

61853:TMPRSS11E
gene id: 61853:TMPRSS11E
uniprot id: G1RDF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61853:LOC100595959
gene id: 61853:LOC100595959
uniprot id: G1S9R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:CD44
gene id: 61853:CD44
uniprot id: A0A2I3GL26
uniprot id: A0A2I3GMY1
uniprot id: A0A2I3GQ93
uniprot id: G1S8E6
uniprot id: M3Z972
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

61853:VAX1
gene id: 61853:VAX1
uniprot id: A0A2I3H569
uniprot id: G1S3J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

61853:CXCL2
gene id: 61853:CXCL2
uniprot id: G1R8Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:UBE2D4
gene id: 61853:UBE2D4
uniprot id: G1QT42
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:SPATA18
gene id: 61853:SPATA18
uniprot id: A0A2I3HUG2
uniprot id: G1R9P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

61853:CBR3
gene id: 61853:CBR3
uniprot id: G1QWH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

61853:STIM2
gene id: 61853:STIM2
uniprot id: A0A2I3H8Q5
uniprot id: G1S509
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:DTX3L
gene id: 61853:DTX3L
uniprot id: A0A2I3H139
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61853:ALAS1
gene id: 61853:ALAS1
uniprot id: G1R616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

61853:UBE2G2
gene id: 61853:UBE2G2
uniprot id: M3Z9V5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:LOC100581891
gene id: 61853:LOC100581891
uniprot id: A0A2I3GM37
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61853:VEGFB
gene id: 61853:VEGFB
uniprot id: G1QY84
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

61853:CUL5
gene id: 61853:CUL5
uniprot id: A0A2I3HAT7
names: Similarity
messages: Belongs to the cullin family.

61853:TBX3
gene id: 61853:TBX3
uniprot id: A0A2I3HGG6
uniprot id: G1QH79
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:BCL7B
gene id: 61853:BCL7B
uniprot id: A0A2I3HTC7
names: Similarity
messages: Belongs to the BCL7 family.

61853:PIH1D2
gene id: 61853:PIH1D2
uniprot id: A0A2I3G345
names: Similarity
messages: Belongs to the PIH1 family.

61853:FOXP4
gene id: 61853:FOXP4
uniprot id: G1QYJ5
names: Subcellular Location Annotation
messages: Nucleus

61853:NEK6
gene id: 61853:NEK6
uniprot id: A0A2I3HIH7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:ANTXR2
gene id: 61853:ANTXR2
uniprot id: G1RAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

61853:CSMD1
gene id: 61853:CSMD1
uniprot id: A0A2I3GDK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:PHF10
gene id: 61853:PHF10
uniprot id: A0A2I3GQF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

61853:CREBBP
gene id: 61853:CREBBP
uniprot id: A0A2I3H346
uniprot id: G1RFB2
names: Subcellular Location Annotation
messages: Cytoplasm

61853:YWHAE
gene id: 61853:YWHAE
uniprot id: A0A2I3HHF3
names: Similarity
messages: Belongs to the 14-3-3 family.

61853:CCDC25
gene id: 61853:CCDC25
uniprot id: G1S3F4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

61853:IFT57
gene id: 61853:IFT57
uniprot id: A0A2I3G7G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

61853:ANXA7
gene id: 61853:ANXA7
uniprot id: G1S404
uniprot id: M3Z9W5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61853:TLX1
gene id: 61853:TLX1
uniprot id: A0A2I3HWY1
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100593952
gene id: 61853:LOC100593952
uniprot id: G1RQC5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:GATC
gene id: 61853:GATC
uniprot id: G1S0F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

61853:KIN
gene id: 61853:KIN
uniprot id: G1RMK2
names: Similarity
messages: Belongs to the KIN17 family.

61853:ASAH1
gene id: 61853:ASAH1
uniprot id: A0A2I3HGS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

61853:PPIA
gene id: 61853:PPIA
uniprot id: A0A248QIH0
uniprot id: Q0ZQK7
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization (By similarity). PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition (By similarity). Acetylation at Lys-125 favors the interaction with TARDBP (By similarity).
messages: Belongs to the cyclophilin-type PPIase family.
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity).
messages: Cytoplasm
messages: Interacts with protein phosphatase PPP3CA/calcineurin A (By similarity). Interacts with isoform 2 of BSG/CD147 (By similarity). Interacts with FOXO1; the interaction promotes FOXO1 dephosphorylation, nuclear accumulation and transcriptional activity (By similarity). Interacts with integrin ITGA2B:ITGB3; the interaction is ROS and peptidyl-prolyl cis-trans isomerase (PPIase) activity-dependent and is increased in the presence of thrombin (By similarity). Interacts with MAP3K5 (By similarity). Interacts with TARDBP; the interaction is dependent on the RNA-binding activity of TARDBP and the PPIase activity of PPIA/CYPA and the acetylation of PPIA/CYPA at Lys-125 favors the interaction (By similarity). Interacts with HNRNPA1, HNRNPA2B1, HNRNPC, RBMX, HNRNPK and HNRNPM (By similarity).
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Secreted

61853:YARS2
gene id: 61853:YARS2
uniprot id: G1S3V3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61853:SLC30A2
gene id: 61853:SLC30A2
uniprot id: A0A2I3HKW8
uniprot id: G1RD69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61853:FABP4
gene id: 61853:FABP4
uniprot id: G1QQ09
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:PEX2
gene id: 61853:PEX2
uniprot id: G1QN94
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

61853:ARHGEF9
gene id: 61853:ARHGEF9
uniprot id: A0A2I3HJH7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
messages: Cytoplasm
messages: Interacts with GPHN.
messages: Postsynaptic density

61853:HDC
gene id: 61853:HDC
uniprot id: A0A2I3G754
uniprot id: G1R2Y0
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61853:DGAT2L6
gene id: 61853:DGAT2L6
uniprot id: G1QJ34
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:EIF3K
gene id: 61853:EIF3K
uniprot id: A0A2I3HRY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

61853:YPEL2
gene id: 61853:YPEL2
uniprot id: A0A2I3GK32
names: Similarity
messages: Belongs to the yippee family.

61853:NPBWR2
gene id: 61853:NPBWR2
uniprot id: G1SBW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:LOC100604844
gene id: 61853:LOC100604844
uniprot id: A0A2I3HVB7
names: Similarity
messages: Belongs to the aldo/keto reductase family.

61853:KCNAB3
gene id: 61853:KCNAB3
uniprot id: A0A2I3HPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm

61853:METTL8
gene id: 61853:METTL8
uniprot id: G1QZZ4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

61853:OPRM1
gene id: 61853:OPRM1
uniprot id: A0A2I3HG76
uniprot id: A0A2I3HW22
uniprot id: G1RZV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

61853:CCSER2
gene id: 61853:CCSER2
uniprot id: A0A2I3HLR5
uniprot id: G1RJD3
uniprot id: G1RJD5
names: Similarity
messages: Belongs to the CCSER family.

61853:LIPC
gene id: 61853:LIPC
uniprot id: A0A2I3G381
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:SLC35A2
gene id: 61853:SLC35A2
uniprot id: G1R8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

61853:NDUFB1
gene id: 61853:NDUFB1
uniprot id: G1S5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:FLOT1
gene id: 61853:FLOT1
uniprot id: G1R0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

61853:STK38L
gene id: 61853:STK38L
uniprot id: M3ZBR7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:OCIAD1
gene id: 61853:OCIAD1
uniprot id: A0A2I3FYY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

61853:SYNGR1
gene id: 61853:SYNGR1
uniprot id: G1RZ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

61853:SEC22C
gene id: 61853:SEC22C
uniprot id: G1R1K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

61853:DNAJC25
gene id: 61853:DNAJC25
uniprot id: A0A2I3H3B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

61853:CDO1
gene id: 61853:CDO1
uniprot id: A0A2I3G8L2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

61853:TFF2
gene id: 61853:TFF2
uniprot id: G1RWR8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SUV39H2
gene id: 61853:SUV39H2
uniprot id: G1RN95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

61853:SDHAF1
gene id: 61853:SDHAF1
uniprot id: G1SB53
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

61853:MCM6
gene id: 61853:MCM6
uniprot id: G1RBX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

61853:ROS1
gene id: 61853:ROS1
uniprot id: G1RSK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

61853:DOK2
gene id: 61853:DOK2
uniprot id: M3ZA98
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

61853:SERPINA4
gene id: 61853:SERPINA4
uniprot id: G1S663
names: Similarity
messages: Belongs to the serpin family.

61853:LOC100601688
gene id: 61853:LOC100601688
uniprot id: G1RIN9
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100593825
gene id: 61853:LOC100593825
uniprot id: A0A2I3HWN6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:CLDN2
gene id: 61853:CLDN2
uniprot id: A0A2I3GE74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:SUCLG2
gene id: 61853:SUCLG2
uniprot id: G1R7K9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

61853:PLOD2
gene id: 61853:PLOD2
uniprot id: A0A2I3HGQ8
uniprot id: G1QYT5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61853:SV2B
gene id: 61853:SV2B
uniprot id: G1RNZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

61853:CHSY3
gene id: 61853:CHSY3
uniprot id: G1RPC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

61853:PPM1N
gene id: 61853:PPM1N
uniprot id: G1QP08
names: Similarity
messages: Belongs to the PP2C family.

61853:SLC6A7
gene id: 61853:SLC6A7
uniprot id: G1RH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61853:REEP5
gene id: 61853:REEP5
uniprot id: G1RLI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

61853:CHN2
gene id: 61853:CHN2
uniprot id: A0A2I3H2B1
names: Function
messages: GTPase-activating protein for p21-rac.

61853:SLC18A2
gene id: 61853:SLC18A2
uniprot id: G1S3N7
names: Subcellular Location Annotation
messages: Membrane

61853:LOC100595480
gene id: 61853:LOC100595480
uniprot id: A0A2I3H4A1
names: Subcellular Location Annotation
messages: Secreted

61853:LOC100594197
gene id: 61853:LOC100594197
uniprot id: A0A2I3HAC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

61853:TM9SF2
gene id: 61853:TM9SF2
uniprot id: A0A2I3GNW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

61853:MYOZ3
gene id: 61853:MYOZ3
uniprot id: G1RHF2
names: Similarity
messages: Belongs to the myozenin family.

61853:TAS2R3
gene id: 61853:TAS2R3
uniprot id: G1S9X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61853:LOC100588156
gene id: 61853:LOC100588156
uniprot id: G1SBG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:POGLUT3
gene id: 61853:POGLUT3
uniprot id: G1R6K8
names: Similarity
messages: Belongs to the KDELC family.

61853:FRAT2
gene id: 61853:FRAT2
uniprot id: G1SBR4
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

61853:RNF8
gene id: 61853:RNF8
uniprot id: G1RK27
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

61853:TMEM198
gene id: 61853:TMEM198
uniprot id: G1REE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

61853:DOK5
gene id: 61853:DOK5
uniprot id: G1R5U3
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

61853:MAP2K1
gene id: 61853:MAP2K1
uniprot id: A0A2I3GXI0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:DARS2
gene id: 61853:DARS2
uniprot id: G1RZB2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

61853:MCM3
gene id: 61853:MCM3
uniprot id: A0A2I3G1N9
uniprot id: G1QUQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

61853:FGF17
gene id: 61853:FGF17
uniprot id: A0A2I3H953
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:RPL39L
gene id: 61853:RPL39L
uniprot id: A0A2I3HXY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

61853:VAX2
gene id: 61853:VAX2
uniprot id: G1RGW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

61853:CHMP4B
gene id: 61853:CHMP4B
uniprot id: G1RG70
names: Similarity
messages: Belongs to the SNF7 family.

61853:ANKRD34C
gene id: 61853:ANKRD34C
uniprot id: A0A2I3HQS6
names: Similarity
messages: Belongs to the ANKRD34 family.

61853:AFF2
gene id: 61853:AFF2
uniprot id: A0A2I3HAG9
names: Similarity
messages: Belongs to the AF4 family.

61853:NOB1
gene id: 61853:NOB1
uniprot id: G1R0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

61853:C14H2orf68
gene id: 61853:C14H2orf68
uniprot id: A0A2I3H392
names: Similarity
messages: Belongs to the UPF0561 family.

61853:S100Z
gene id: 61853:S100Z
uniprot id: G1RQ12
names: Similarity
messages: Belongs to the S-100 family.

61853:NFYA
gene id: 61853:NFYA
uniprot id: G1QYT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

61853:EFS
gene id: 61853:EFS
uniprot id: G1RYE2
names: Similarity
messages: Belongs to the CAS family.

61853:TCIRG1
gene id: 61853:TCIRG1
uniprot id: G1R426
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

61853:MMAB
gene id: 61853:MMAB
uniprot id: G1QNU1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

61853:C6
gene id: 61853:C6
uniprot id: G1S3V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:TAC3
gene id: 61853:TAC3
uniprot id: G1S6L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted

61853:ZFX
gene id: 61853:ZFX
uniprot id: A0A2I3GH74
uniprot id: A0A2I3H6E2
uniprot id: G1RGA3
names: Subcellular Location Annotation
messages: Nucleus

61853:NMS
gene id: 61853:NMS
uniprot id: G1RW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

61853:EEF2KMT
gene id: 61853:EEF2KMT
uniprot id: G1QRW4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

61853:DSC1
gene id: 61853:DSC1
uniprot id: G1R400
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61853:LOC100606303
gene id: 61853:LOC100606303
uniprot id: G1QP91
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:TPD52L1
gene id: 61853:TPD52L1
uniprot id: A0A2I3G973
uniprot id: A0A2I3GPD5
uniprot id: A0A2I3HD31
uniprot id: A0A2I3HJZ9
uniprot id: A0A2I3HU83
uniprot id: G1RUL0
names: Similarity
messages: Belongs to the TPD52 family.

61853:GAB1
gene id: 61853:GAB1
uniprot id: A0A2I3GSD3
uniprot id: G1QZZ2
names: Similarity
messages: Belongs to the GAB family.

61853:NUDCD1
gene id: 61853:NUDCD1
uniprot id: A0A2I3GNR5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:IBSP
gene id: 61853:IBSP
uniprot id: G1REL7
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

61853:CD59
gene id: 61853:CD59
uniprot id: A0A2I3HZX1
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane

61853:DDAH2
gene id: 61853:DDAH2
uniprot id: G1R336
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

61853:LOC101179576
gene id: 61853:LOC101179576
uniprot id: A0A2I3GVV1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

61853:UBR1
gene id: 61853:UBR1
uniprot id: G1QXP3
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

61853:IRX5
gene id: 61853:IRX5
uniprot id: G1QKF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

61853:GJD4
gene id: 61853:GJD4
uniprot id: G1S963
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:SLC19A2
gene id: 61853:SLC19A2
uniprot id: G1RY86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

61853:NPBWR1
gene id: 61853:NPBWR1
uniprot id: G1S9U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ODC1
gene id: 61853:ODC1
uniprot id: G1RU71
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

61853:CHRNB2
gene id: 61853:CHRNB2
uniprot id: G1RL13
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:NNT
gene id: 61853:NNT
uniprot id: G1RHY8
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

61853:KCND2
gene id: 61853:KCND2
uniprot id: A0A2I3GR32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

61853:LOC101177997
gene id: 61853:LOC101177997
uniprot id: A0A2I3I0G1
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

61853:ZNF500
gene id: 61853:ZNF500
uniprot id: A0A2I3HQU0
names: Subcellular Location Annotation
messages: Nucleus

61853:MAPK7
gene id: 61853:MAPK7
uniprot id: G1RBW1
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

61853:TRPC3
gene id: 61853:TRPC3
uniprot id: G1RDX0
names: Subcellular Location Annotation
messages: Membrane

61853:MED4
gene id: 61853:MED4
uniprot id: G1QRT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:FMO2
gene id: 61853:FMO2
uniprot id: G1RYT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61853:GSX1
gene id: 61853:GSX1
uniprot id: G1QHN9
names: Subcellular Location Annotation
messages: Nucleus

61853:SDR9C7
gene id: 61853:SDR9C7
uniprot id: G1S6M2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:LOC100588339
gene id: 61853:LOC100588339
uniprot id: A0A2I3HZ90
uniprot id: G1S496
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

61853:TRAPPC2
gene id: 61853:TRAPPC2
uniprot id: G1RD70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

61853:JPH1
gene id: 61853:JPH1
uniprot id: G1QM66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

61853:GRK7
gene id: 61853:GRK7
uniprot id: G1QXH1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61853:SLCO6A1
gene id: 61853:SLCO6A1
uniprot id: A0A2I3FWQ0
uniprot id: A0A2I3H1X2
uniprot id: G1RJ49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:MYO3B
gene id: 61853:MYO3B
uniprot id: G1QZ91
uniprot id: G1QZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

61853:DGCR6L
gene id: 61853:DGCR6L
uniprot id: A0A2I3G1L4
names: Similarity
messages: Belongs to the gonadal family.

61853:KRT18
gene id: 61853:KRT18
uniprot id: G1S7N3
names: Similarity
messages: Belongs to the intermediate filament family.

61853:RGMB
gene id: 61853:RGMB
uniprot id: G1RWJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

61853:CDH20
gene id: 61853:CDH20
uniprot id: G1RAV5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:NUP205
gene id: 61853:NUP205
uniprot id: G1RT58
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

61853:FAH
gene id: 61853:FAH
uniprot id: G1RCF9
names: Similarity
messages: Belongs to the FAH family.

61853:ARF3
gene id: 61853:ARF3
uniprot id: A0A2I3GEQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61853:TMEM106C
gene id: 61853:TMEM106C
uniprot id: G1S8A6
names: Similarity
messages: Belongs to the TMEM106 family.

61853:FAM3B
gene id: 61853:FAM3B
uniprot id: A0A2I3HFI4
uniprot id: G1RBB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

61853:ANAPC13
gene id: 61853:ANAPC13
uniprot id: G1QUB7
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

61853:CTLA4
gene id: 61853:CTLA4
uniprot id: A0A2I3FRI8
uniprot id: G1R5Y1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

61853:DERL3
gene id: 61853:DERL3
uniprot id: G1QIB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

61853:SUSD4
gene id: 61853:SUSD4
uniprot id: A0A2I3GLI7
uniprot id: G1QI11
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CELF6
gene id: 61853:CELF6
uniprot id: A0A2I3HP85
uniprot id: G1RUL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

61853:ATP2A2
gene id: 61853:ATP2A2
uniprot id: A0A2I3HQE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61853:ORC4
gene id: 61853:ORC4
uniprot id: G1RCY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

61853:ERO1A
gene id: 61853:ERO1A
uniprot id: G1RPM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

61853:EXOC2
gene id: 61853:EXOC2
uniprot id: G1RIT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

61853:OSBPL1A
gene id: 61853:OSBPL1A
uniprot id: G1R4D5
names: Similarity
messages: Belongs to the OSBP family.

61853:POLR3B
gene id: 61853:POLR3B
uniprot id: A0A2I3H6C8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61853:EPCAM
gene id: 61853:EPCAM
uniprot id: G1RAJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
messages: Membrane
messages: tight junction

61853:HGF
gene id: 61853:HGF
uniprot id: A0A2I3GPI4
uniprot id: G1RXL8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

61853:LOC100587403
gene id: 61853:LOC100587403
uniprot id: A0A2I3HIA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:CA10
gene id: 61853:CA10
uniprot id: G1R914
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

61853:IL2RA
gene id: 61853:IL2RA
uniprot id: A0A2I3GVZ5
uniprot id: G1RLR0
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

61853:DYNLT3
gene id: 61853:DYNLT3
uniprot id: G1QJS2
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61853:PPP1R14A
gene id: 61853:PPP1R14A
uniprot id: G1S4X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

61853:TMEM9
gene id: 61853:TMEM9
uniprot id: G1S8X1
names: Similarity
messages: Belongs to the TMEM9 family.

61853:PTCH1
gene id: 61853:PTCH1
uniprot id: G1S4D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

61853:LYZL4
gene id: 61853:LYZL4
uniprot id: G1R1F8
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

61853:FOPNL
gene id: 61853:FOPNL
uniprot id: G1QGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

61853:ITPKA
gene id: 61853:ITPKA
uniprot id: G1QTX2
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61853:EDIL3
gene id: 61853:EDIL3
uniprot id: G1RSR1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:EXO5
gene id: 61853:EXO5
uniprot id: A0A2I3G362
names: Similarity
messages: Belongs to the EXO5 family.

61853:FBXO32
gene id: 61853:FBXO32
uniprot id: G1QZV8
names: Subcellular Location Annotation
messages: Nucleus

61853:RNF7
gene id: 61853:RNF7
uniprot id: A0A2I3GDA7
names: Similarity
messages: Belongs to the RING-box family.

61853:ACTG2
gene id: 61853:ACTG2
uniprot id: A0A2I3G1L5
names: Similarity
messages: Belongs to the actin family.

61853:SH2D1A
gene id: 61853:SH2D1A
uniprot id: G1RYQ3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.

61853:GPR68
gene id: 61853:GPR68
uniprot id: G1SC85
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:CLDN12
gene id: 61853:CLDN12
uniprot id: G1RYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

61853:PRAF2
gene id: 61853:PRAF2
uniprot id: A0A2I3GYW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

61853:APAF1
gene id: 61853:APAF1
uniprot id: G1R2E0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Monomer. Oligomerizes upon binding of cytochrome c and dATP.
messages: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

61853:KCNMB4
gene id: 61853:KCNMB4
uniprot id: A0A2I3FT66
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

61853:DBNDD1
gene id: 61853:DBNDD1
uniprot id: G1S1R9
names: Similarity
messages: Belongs to the dysbindin family.

61853:MED14
gene id: 61853:MED14
uniprot id: G1QMM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61853:SEMA6A
gene id: 61853:SEMA6A
uniprot id: A0A2I3HCY1
uniprot id: A0A2I3HLT7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TMEM176A
gene id: 61853:TMEM176A
uniprot id: G1QUV7
names: Similarity
messages: Belongs to the TMEM176 family.

61853:SLC39A4
gene id: 61853:SLC39A4
uniprot id: G1RIF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

61853:RRAD
gene id: 61853:RRAD
uniprot id: G1QVR6
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61853:ZNF687
gene id: 61853:ZNF687
uniprot id: G1RGN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

61853:WDPCP
gene id: 61853:WDPCP
uniprot id: G1RFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat fritz family.
messages: Cell membrane
messages: Membrane
messages: cilium axoneme

61853:PNLDC1
gene id: 61853:PNLDC1
uniprot id: G1RKI3
names: Similarity
messages: Belongs to the CAF1 family.

61853:LOC100598772
gene id: 61853:LOC100598772
uniprot id: A0A2I3GMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61853:SNAP25
gene id: 61853:SNAP25
uniprot id: A0A2I3FZK1
uniprot id: G1RWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

61853:TIGD4
gene id: 61853:TIGD4
uniprot id: G1R1S0
names: Subcellular Location Annotation
messages: Nucleus

61853:AASDH
gene id: 61853:AASDH
uniprot id: G1RBT3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61853:S100PBP
gene id: 61853:S100PBP
uniprot id: A0A2I3GKU9
names: Subcellular Location Annotation
messages: Nucleus

61853:MYH8
gene id: 61853:MYH8
uniprot id: G1RGR0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61853:CFAP300
gene id: 61853:CFAP300
uniprot id: G1R6A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

61853:SNX21
gene id: 61853:SNX21
uniprot id: A0A2I3GIE8
uniprot id: A0A2I3HIP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

61853:GPM6B
gene id: 61853:GPM6B
uniprot id: A0A2I3GJY7
uniprot id: G1RDG0
uniprot id: M3ZAY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

61853:CLDN22
gene id: 61853:CLDN22
uniprot id: G1SB40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:MTM1
gene id: 61853:MTM1
uniprot id: G1RT83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

61853:INTS13
gene id: 61853:INTS13
uniprot id: G1R014
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

61853:SLC16A13
gene id: 61853:SLC16A13
uniprot id: G1RDS4
names: Subcellular Location Annotation
messages: Membrane

61853:ASB17
gene id: 61853:ASB17
uniprot id: G1RER4
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

61853:ITM2A
gene id: 61853:ITM2A
uniprot id: G1QIT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

61853:LOC100580355
gene id: 61853:LOC100580355
uniprot id: G1RGY1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61853:RELN
gene id: 61853:RELN
uniprot id: G1RD90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the reelin family.
messages: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2.
messages: extracellular matrix

61853:CFAP52
gene id: 61853:CFAP52
uniprot id: A0A2I3H6G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP52 family.
messages: cilium axoneme
messages: flagellum

61853:TAF5
gene id: 61853:TAF5
uniprot id: G1RZ30
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

61853:ZNF263
gene id: 61853:ZNF263
uniprot id: G1REP5
names: Subcellular Location Annotation
messages: Nucleus

61853:ACTRT3
gene id: 61853:ACTRT3
uniprot id: G1QYU7
names: Similarity
messages: Belongs to the actin family.

61853:AQP7
gene id: 61853:AQP7
uniprot id: G1QYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61853:DDX6
gene id: 61853:DDX6
uniprot id: G1R720
names: Similarity
messages: Belongs to the DEAD box helicase family.

61853:TRUB1
gene id: 61853:TRUB1
uniprot id: G1S2U4
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

61853:PRKG1
gene id: 61853:PRKG1
uniprot id: G1RMZ0
uniprot id: G1RMZ8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

61853:CPA2
gene id: 61853:CPA2
uniprot id: G1RQH3
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:TMEM14A
gene id: 61853:TMEM14A
uniprot id: A0A2I3HRX6
names: Similarity
messages: Belongs to the TMEM14 family.

61853:CDC73
gene id: 61853:CDC73
uniprot id: G1S8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

61853:CKS1B
gene id: 61853:CKS1B
uniprot id: G1RLC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

61853:TGFB3
gene id: 61853:TGFB3
uniprot id: G1S3M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

61853:ADAM9
gene id: 61853:ADAM9
uniprot id: A0A2I3GER4
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:GIMAP8
gene id: 61853:GIMAP8
uniprot id: G1QUJ8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61853:C2H5orf30
gene id: 61853:C2H5orf30
uniprot id: G1RK31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

61853:GPR15
gene id: 61853:GPR15
uniprot id: G1S9Z1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:PMM2
gene id: 61853:PMM2
uniprot id: A0A2I3GIK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

61853:HPGD
gene id: 61853:HPGD
uniprot id: G1R4P1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:RRAGB
gene id: 61853:RRAGB
uniprot id: A0A2I3GMS9
uniprot id: G1S2U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

61853:SKIL
gene id: 61853:SKIL
uniprot id: A0A2I3HLQ5
names: Similarity
messages: Belongs to the SKI family.

61853:PIGU
gene id: 61853:PIGU
uniprot id: A0A2I3G943
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:CASTOR1
gene id: 61853:CASTOR1
uniprot id: A0A2I3GI52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

61853:LOC100584415
gene id: 61853:LOC100584415
uniprot id: G1QU61
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61853:PDCD10
gene id: 61853:PDCD10
uniprot id: G1QYB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

61853:FAM83C
gene id: 61853:FAM83C
uniprot id: G1RGV3
names: Similarity
messages: Belongs to the FAM83 family.

61853:IFNB1
gene id: 61853:IFNB1
uniprot id: G1SBE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:ST8SIA3
gene id: 61853:ST8SIA3
uniprot id: A0A2I3HDR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:SIM1
gene id: 61853:SIM1
uniprot id: G1RUD0
names: Subcellular Location Annotation
messages: Nucleus

61853:C9
gene id: 61853:C9
uniprot id: G1S351
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted
messages: Target cell membrane

61853:NEK8
gene id: 61853:NEK8
uniprot id: G1QRK6
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

61853:CD28
gene id: 61853:CD28
uniprot id: A0A2I3HMY4
uniprot id: G1R5X7
names: Subcellular Location Annotation
messages: Membrane

61853:BVES
gene id: 61853:BVES
uniprot id: G1RVB5
names: Similarity
messages: Belongs to the popeye family.

61853:HMGCLL1
gene id: 61853:HMGCLL1
uniprot id: G1QSR6
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

61853:OTOP2
gene id: 61853:OTOP2
uniprot id: G1QI62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61853:IDNK
gene id: 61853:IDNK
uniprot id: A0A2I3GDV0
uniprot id: A0A2I3GKW0
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

61853:TRMT1L
gene id: 61853:TRMT1L
uniprot id: G1S8R4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

61853:NEUROD4
gene id: 61853:NEUROD4
uniprot id: A0A2I3HLJ8
names: Subcellular Location Annotation
messages: Nucleus

61853:STK17A
gene id: 61853:STK17A
uniprot id: G1QSU4
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:GRK5
gene id: 61853:GRK5
uniprot id: G1S461
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61853:MCIDAS
gene id: 61853:MCIDAS
uniprot id: G1QKK2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geminin family.
messages: Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.
messages: Nucleus

61853:ENTR1
gene id: 61853:ENTR1
uniprot id: A0A2I3HNT4
uniprot id: G1R9U7
names: Similarity
messages: Belongs to the ENTR1 family.

61853:LOC100583725
gene id: 61853:LOC100583725
uniprot id: A0A2I3HMN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:NOP58
gene id: 61853:NOP58
uniprot id: G1R5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

61853:VIP
gene id: 61853:VIP
uniprot id: G1RZQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

61853:FABP12
gene id: 61853:FABP12
uniprot id: G1QQ39
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:MDM4
gene id: 61853:MDM4
uniprot id: A0A2I3HP90
uniprot id: M3ZAC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

61853:ALDH6A1
gene id: 61853:ALDH6A1
uniprot id: A0A2I3HEX6
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

61853:KPNA7
gene id: 61853:KPNA7
uniprot id: G1RIW6
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61853:CCN3
gene id: 61853:CCN3
uniprot id: G1QYD1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:IL17F
gene id: 61853:IL17F
uniprot id: G1QUR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61853:PPP2R5A
gene id: 61853:PPP2R5A
uniprot id: A0A2I3GXD4
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61853:NUDT6
gene id: 61853:NUDT6
uniprot id: A0A2I3FPU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

61853:ACMSD
gene id: 61853:ACMSD
uniprot id: G1RAK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

61853:HYI
gene id: 61853:HYI
uniprot id: A0A2I3HZY4
names: Function
names: Similarity
messages: Belongs to the hyi family.
messages: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

61853:FAM53B
gene id: 61853:FAM53B
uniprot id: G1QI75
names: Similarity
messages: Belongs to the FAM53 family.

61853:BTF3
gene id: 61853:BTF3
uniprot id: A0A2I3G128
names: Similarity
messages: Belongs to the NAC-beta family.

61853:STAC3
gene id: 61853:STAC3
uniprot id: G1S6D3
names: Subcellular Location Annotation
messages: sarcolemma

61853:KATNA1
gene id: 61853:KATNA1
uniprot id: G1RZC6
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: spindle
messages: spindle pole

61853:CPSF4
gene id: 61853:CPSF4
uniprot id: G1RJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

61853:DHH
gene id: 61853:DHH
uniprot id: G1S840
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

61853:SLC25A38
gene id: 61853:SLC25A38
uniprot id: G1R0S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

61853:LOC100598295
gene id: 61853:LOC100598295
uniprot id: A0A2I3HN99
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61853:DEFB108B
gene id: 61853:DEFB108B
uniprot id: A0A2I3G9Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61853:LOC100597887
gene id: 61853:LOC100597887
uniprot id: A0A2I3HR35
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61853:FABP3
gene id: 61853:FABP3
uniprot id: A0A2I3GZJ2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:PRORP
gene id: 61853:PRORP
uniprot id: M3ZAS6
names: Similarity
messages: Belongs to the PPR family. P subfamily.

61853:DGUOK
gene id: 61853:DGUOK
uniprot id: A0A2I3I0A1
names: Similarity
messages: Belongs to the DCK/DGK family.

61853:SRFBP1
gene id: 61853:SRFBP1
uniprot id: G1RMR5
names: Function
names: Subunit
messages: Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.
messages: May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

61853:TUBB
gene id: 61853:TUBB
uniprot id: G1R063
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61853:AVPR1B
gene id: 61853:AVPR1B
uniprot id: G1QHX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

61853:ADAMTS9
gene id: 61853:ADAMTS9
uniprot id: G1RMK1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:ARL4D
gene id: 61853:ARL4D
uniprot id: A0A2I3HI15
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61853:SNAPC3
gene id: 61853:SNAPC3
uniprot id: G1S768
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

61853:CCT2
gene id: 61853:CCT2
uniprot id: G1QV23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

61853:TGM7
gene id: 61853:TGM7
uniprot id: G1QYD9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61853:UMODL1
gene id: 61853:UMODL1
uniprot id: G1RWQ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:MRPL17
gene id: 61853:MRPL17
uniprot id: A0A2I3HYX7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

61853:EMC9
gene id: 61853:EMC9
uniprot id: A0A2I3HXT1
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

61853:SBDS
gene id: 61853:SBDS
uniprot id: G1RSB1
names: Function
names: Similarity
messages: Belongs to the SDO1/SBDS family.
messages: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

61853:INHBE
gene id: 61853:INHBE
uniprot id: G1S6B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

61853:APOH
gene id: 61853:APOH
uniprot id: G1QHF4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:TARDBP
gene id: 61853:TARDBP
uniprot id: A0A2I3G8J5
names: Subcellular Location Annotation
messages: Nucleus

61853:GALNT3
gene id: 61853:GALNT3
uniprot id: G1QSK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:BZW1
gene id: 61853:BZW1
uniprot id: A0A2I3GJS9
names: Similarity
messages: Belongs to the BZW family.

61853:DNTT
gene id: 61853:DNTT
uniprot id: G1RSJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

61853:NDUFB2
gene id: 61853:NDUFB2
uniprot id: A0A2I3GQL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:DHX29
gene id: 61853:DHX29
uniprot id: G1QLC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

61853:LOC100598671
gene id: 61853:LOC100598671
uniprot id: G1S9R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:ACOX1
gene id: 61853:ACOX1
uniprot id: G1QN40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61853:H1-4
gene id: 61853:H1-4
uniprot id: G1S9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61853:REEP1
gene id: 61853:REEP1
uniprot id: G1QR15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

61853:DGKA
gene id: 61853:DGKA
uniprot id: G1S754
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61853:SPOCK1
gene id: 61853:SPOCK1
uniprot id: A0A2I3HGL0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CHST11
gene id: 61853:CHST11
uniprot id: M3ZAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:LOC100607576
gene id: 61853:LOC100607576
uniprot id: G1S9Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:GALNT18
gene id: 61853:GALNT18
uniprot id: G1S7D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:NAP1L1
gene id: 61853:NAP1L1
uniprot id: G1QXS6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61853:HIBCH
gene id: 61853:HIBCH
uniprot id: A0A2I3HX46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

61853:CXCL13
gene id: 61853:CXCL13
uniprot id: G1R9S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:ST7
gene id: 61853:ST7
uniprot id: A0A2I3GU99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

61853:CREBL2
gene id: 61853:CREBL2
uniprot id: G1QTR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

61853:SLC9A8
gene id: 61853:SLC9A8
uniprot id: G1R5N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

61853:VGLL3
gene id: 61853:VGLL3
uniprot id: G1RM70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

61853:RPL35A
gene id: 61853:RPL35A
uniprot id: A0A2I3H7B7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

61853:MRPL50
gene id: 61853:MRPL50
uniprot id: G1S5I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

61853:ACOT13
gene id: 61853:ACOT13
uniprot id: G1QQ55
names: Similarity
messages: Belongs to the thioesterase PaaI family.

61853:PRR5L
gene id: 61853:PRR5L
uniprot id: G1S8G4
names: Similarity
messages: Belongs to the PROTOR family.

61853:SEC61B
gene id: 61853:SEC61B
uniprot id: G1S5C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

61853:APOO
gene id: 61853:APOO
uniprot id: G1RG77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

61853:CCL20
gene id: 61853:CCL20
uniprot id: A0A2I3GWS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61853:PDGFRL
gene id: 61853:PDGFRL
uniprot id: G1QQU9
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

61853:LMNB1
gene id: 61853:LMNB1
uniprot id: G1RNS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

61853:MRPL1
gene id: 61853:MRPL1
uniprot id: G1R9X5
names: Subcellular Location Annotation
messages: Mitochondrion

61853:KDR
gene id: 61853:KDR
uniprot id: G1RAQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

61853:LEPR
gene id: 61853:LEPR
uniprot id: A0A2I3H2H9
uniprot id: A0A2I3HGX7
uniprot id: G1RYZ2
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

61853:FRK
gene id: 61853:FRK
uniprot id: G1RRJ9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61853:PDE4B
gene id: 61853:PDE4B
uniprot id: A0A2I3GA09
uniprot id: A0A2I3GLK0
uniprot id: A0A2I3HRD9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:ACTL7A
gene id: 61853:ACTL7A
uniprot id: G1SBD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Golgi apparatus
messages: May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.
messages: Nucleus
messages: cytoskeleton

61853:ZNF165
gene id: 61853:ZNF165
uniprot id: G1QWS9
names: Subcellular Location Annotation
messages: Nucleus

61853:PDGFRB
gene id: 61853:PDGFRB
uniprot id: G1RGZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

61853:ARSH
gene id: 61853:ARSH
uniprot id: A0A2I3GZG1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61853:STXBP5
gene id: 61853:STXBP5
uniprot id: A0A2I3GPE1
uniprot id: A0A2I3GWC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61853:ANAPC5
gene id: 61853:ANAPC5
uniprot id: G1S249
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

61853:NDC80
gene id: 61853:NDC80
uniprot id: G1R5A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

61853:KIF5B
gene id: 61853:KIF5B
uniprot id: G1S940
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:PSMD8
gene id: 61853:PSMD8
uniprot id: G1S4R1
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

61853:FGF22
gene id: 61853:FGF22
uniprot id: G1QJ57
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:LOC100600433
gene id: 61853:LOC100600433
uniprot id: G1SAF6
names: Similarity
messages: Belongs to the GroES chaperonin family.

61853:LOC100580500
gene id: 61853:LOC100580500
uniprot id: G1RRR6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:CD74
gene id: 61853:CD74
uniprot id: G1RHB8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:GAPVD1
gene id: 61853:GAPVD1
uniprot id: A0A2I3GS49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

61853:SLC4A7
gene id: 61853:SLC4A7
uniprot id: A0A2I3GIX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

61853:OVOL1
gene id: 61853:OVOL1
uniprot id: G1R1J8
names: Subcellular Location Annotation
messages: Nucleus

61853:HYAL2
gene id: 61853:HYAL2
uniprot id: G1R5P7
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

61853:KLHL15
gene id: 61853:KLHL15
uniprot id: G1RG82
names: Subcellular Location Annotation
messages: Nucleus

61853:GBP4
gene id: 61853:GBP4
uniprot id: G1RGY5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61853:IFNL1
gene id: 61853:IFNL1
uniprot id: G1RWJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

61853:TIPARP
gene id: 61853:TIPARP
uniprot id: G1QV49
names: Similarity
messages: Belongs to the ARTD/PARP family.

61853:FITM2
gene id: 61853:FITM2
uniprot id: A0A2I3HA86
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:FRZB
gene id: 61853:FRZB
uniprot id: G1R3H6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

61853:GNMT
gene id: 61853:GNMT
uniprot id: A0A2I3HXZ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

61853:SSTR3
gene id: 61853:SSTR3
uniprot id: G1RXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ATP6V1A
gene id: 61853:ATP6V1A
uniprot id: G1QXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: clathrin-coated vesicle membrane
messages: secretory vesicle

61853:C16H8orf37
gene id: 61853:C16H8orf37
uniprot id: A0A2I3HJQ0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

61853:CENPQ
gene id: 61853:CENPQ
uniprot id: A0A2I3HSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

61853:KIF5C
gene id: 61853:KIF5C
uniprot id: A0A2I3HDE4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:MTX2
gene id: 61853:MTX2
uniprot id: G1R269
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

61853:CTSE
gene id: 61853:CTSE
uniprot id: G1QHW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

61853:LIPN
gene id: 61853:LIPN
uniprot id: G1RNK6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61853:LOC100589309
gene id: 61853:LOC100589309
uniprot id: G1SAV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:RMND1
gene id: 61853:RMND1
uniprot id: G1RZK4
names: Similarity
messages: Belongs to the RMD1/sif2 family.

61853:C10H19orf53
gene id: 61853:C10H19orf53
uniprot id: G1RRR4
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

61853:LCN10
gene id: 61853:LCN10
uniprot id: A0A2I3H5U3
uniprot id: G1RAE5
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61853:CAPZA1
gene id: 61853:CAPZA1
uniprot id: A0A2I3GTL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

61853:HSP90B1
gene id: 61853:HSP90B1
uniprot id: G1R417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

61853:SLC24A2
gene id: 61853:SLC24A2
uniprot id: G1S6Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

61853:C1AH9orf64
gene id: 61853:C1AH9orf64
uniprot id: G1QTD8
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

61853:SULT4A1
gene id: 61853:SULT4A1
uniprot id: G1S0E7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:LIMK2
gene id: 61853:LIMK2
uniprot id: A0A2I3GXP6
uniprot id: A0A2I3HL37
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

61853:NIPA1
gene id: 61853:NIPA1
uniprot id: A0A2I3H2Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61853:TRADD
gene id: 61853:TRADD
uniprot id: G1QWB5
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

61853:LOC100606797
gene id: 61853:LOC100606797
uniprot id: A0A2I3H409
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

61853:INA
gene id: 61853:INA
uniprot id: G1RZ13
names: Similarity
messages: Belongs to the intermediate filament family.

61853:PPFIBP1
gene id: 61853:PPFIBP1
uniprot id: A0A2I3H4U3
uniprot id: A0A2I3HQ68
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

61853:ISYNA1
gene id: 61853:ISYNA1
uniprot id: G1R290
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

61853:MAT2B
gene id: 61853:MAT2B
uniprot id: A0A2I3GF32
uniprot id: G1QY02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

61853:LOC100602956
gene id: 61853:LOC100602956
uniprot id: A0A2I3GNX5
names: Similarity
messages: Belongs to the histone H2B family.

61853:TRPM1
gene id: 61853:TRPM1
uniprot id: A0A2I3H076
uniprot id: G1R7K4
names: Subcellular Location Annotation
messages: Membrane

61853:ZDHHC1
gene id: 61853:ZDHHC1
uniprot id: G1QXH3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:RTN3
gene id: 61853:RTN3
uniprot id: A0A2I3G3F8
uniprot id: G1QXF0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:NDUFB6
gene id: 61853:NDUFB6
uniprot id: G1QZX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:LANCL3
gene id: 61853:LANCL3
uniprot id: A0A2I3GFS1
uniprot id: G1QJI0
names: Similarity
messages: Belongs to the LanC-like protein family.

61853:ESRRA
gene id: 61853:ESRRA
uniprot id: G1QYL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61853:RPL34
gene id: 61853:RPL34
uniprot id: G1RR30
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

61853:CCL21
gene id: 61853:CCL21
uniprot id: G1QXX4
names: Subcellular Location Annotation
messages: Secreted

61853:GALK1
gene id: 61853:GALK1
uniprot id: G1QLN1
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

61853:CDKN2AIP
gene id: 61853:CDKN2AIP
uniprot id: G1RIG6
names: Similarity
messages: Belongs to the CARF family.

61853:SERPINB1
gene id: 61853:SERPINB1
uniprot id: G1RJE1
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

61853:FOXO1
gene id: 61853:FOXO1
uniprot id: G1QKB1
names: Subcellular Location Annotation
messages: Nucleus

61853:DDX18
gene id: 61853:DDX18
uniprot id: G1RM95
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

61853:POLR3H
gene id: 61853:POLR3H
uniprot id: G1S030
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

61853:PMEL
gene id: 61853:PMEL
uniprot id: A0A2I3H627
names: Similarity
messages: Belongs to the PMEL/NMB family.

61853:GPATCH1
gene id: 61853:GPATCH1
uniprot id: G1R7Z8
names: Similarity
messages: Belongs to the GPATCH1 family.

61853:FAM228A
gene id: 61853:FAM228A
uniprot id: G1QJE2
names: Similarity
messages: Belongs to the FAM228 family.

61853:EHD1
gene id: 61853:EHD1
uniprot id: A0A2I3GDQ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: cilium membrane

61853:LOC100588957
gene id: 61853:LOC100588957
uniprot id: A0A2I3GNK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

61853:EPHA2
gene id: 61853:EPHA2
uniprot id: G1R858
names: Subcellular Location Annotation
messages: Membrane

61853:DES
gene id: 61853:DES
uniprot id: G1RE59
names: Similarity
messages: Belongs to the intermediate filament family.

61853:CHRDL1
gene id: 61853:CHRDL1
uniprot id: A0A2I3GGV1
names: Subcellular Location Annotation
messages: Secreted

61853:RPA1
gene id: 61853:RPA1
uniprot id: G1S5P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

61853:LOC100583780
gene id: 61853:LOC100583780
uniprot id: G1SBU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PRKCE
gene id: 61853:PRKCE
uniprot id: G1S4U2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

61853:SLC17A8
gene id: 61853:SLC17A8
uniprot id: A0A2I3GWJ1
uniprot id: G1R2F7
names: Subcellular Location Annotation
messages: Membrane

61853:GABRG1
gene id: 61853:GABRG1
uniprot id: G1S687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61853:MST1
gene id: 61853:MST1
uniprot id: G1R5A0
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:BLOC1S6
gene id: 61853:BLOC1S6
uniprot id: A0A2I3GWD7
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

61853:ACADS
gene id: 61853:ACADS
uniprot id: G1S1B1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61853:STK32A
gene id: 61853:STK32A
uniprot id: A0A2I3G4Q9
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:PPFIA2
gene id: 61853:PPFIA2
uniprot id: A0A2I3GE29
uniprot id: A0A2I3GM61
uniprot id: A0A2I3GU64
uniprot id: A0A2I3HS41
uniprot id: G1QZL7
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

61853:PATL2
gene id: 61853:PATL2
uniprot id: G1R112
names: Similarity
messages: Belongs to the PAT1 family.

61853:EID2B
gene id: 61853:EID2B
uniprot id: A0A2I3FXA3
names: Subcellular Location Annotation
messages: Nucleus

61853:MARS1
gene id: 61853:MARS1
uniprot id: G1S689
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61853:QTRT2
gene id: 61853:QTRT2
uniprot id: A0A2I3HE29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

61853:VAMP4
gene id: 61853:VAMP4
uniprot id: G1RYX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61853:PRIMPOL
gene id: 61853:PRIMPOL
uniprot id: G1RJ98
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

61853:BLOC1S1
gene id: 61853:BLOC1S1
uniprot id: A0A2I3GUI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S1 family.
messages: Lysosome membrane
messages: May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.
messages: Mitochondrion intermembrane space

61853:EIF4G2
gene id: 61853:EIF4G2
uniprot id: A0A2I3FWW3
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

61853:TMEM144
gene id: 61853:TMEM144
uniprot id: G1R3D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

61853:LOC100595691
gene id: 61853:LOC100595691
uniprot id: A0A2I3GKR0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:IL19
gene id: 61853:IL19
uniprot id: G1QJ45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

61853:MPP5
gene id: 61853:MPP5
uniprot id: G1QIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

61853:SLC5A8
gene id: 61853:SLC5A8
uniprot id: G1R2Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61853:TMEM256
gene id: 61853:TMEM256
uniprot id: A0A2I3HHC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

61853:SSH2
gene id: 61853:SSH2
uniprot id: G1QTP5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

61853:KDM5A
gene id: 61853:KDM5A
uniprot id: G1QNE9
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

61853:MRPS31
gene id: 61853:MRPS31
uniprot id: G1QKE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

61853:PEX14
gene id: 61853:PEX14
uniprot id: G1REA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the peroxisomal translocation machinery.
messages: Peroxisome membrane

61853:TMEM126B
gene id: 61853:TMEM126B
uniprot id: A0A2I3H6I0
uniprot id: G1S330
names: Subcellular Location Annotation
messages: Membrane

61853:KIF16B
gene id: 61853:KIF16B
uniprot id: A0A2I3G9E5
uniprot id: A0A2I3GBA1
uniprot id: A0A2I3HLC8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:PLPP1
gene id: 61853:PLPP1
uniprot id: G1QLH2
uniprot id: M3ZC32
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

61853:SGO1
gene id: 61853:SGO1
uniprot id: A0A2I3GJH9
uniprot id: A0A2I3HL99
uniprot id: G1QTK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

61853:CREB1
gene id: 61853:CREB1
uniprot id: G1R662
uniprot id: M3Z9R8
names: Subcellular Location Annotation
messages: Nucleus

61853:SDE2
gene id: 61853:SDE2
uniprot id: G1RU05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

61853:MSRB3
gene id: 61853:MSRB3
uniprot id: A0A2I3H5Y7
uniprot id: G1QSA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

61853:HSCB
gene id: 61853:HSCB
uniprot id: G1QPI3
names: Similarity
messages: Belongs to the HscB family.

61853:ACAD8
gene id: 61853:ACAD8
uniprot id: G1RPQ0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61853:MLH3
gene id: 61853:MLH3
uniprot id: A0A2I3FYF7
uniprot id: G1S353
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

61853:S1PR3
gene id: 61853:S1PR3
uniprot id: G1RBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:GNA12
gene id: 61853:GNA12
uniprot id: A0A2I3G8L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

61853:FAM151B
gene id: 61853:FAM151B
uniprot id: G1RR87
names: Similarity
messages: Belongs to the FAM151 family.

61853:AGMAT
gene id: 61853:AGMAT
uniprot id: G1R7U7
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

61853:SMDT1
gene id: 61853:SMDT1
uniprot id: G1S0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61853:TWF1
gene id: 61853:TWF1
uniprot id: G1S8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

61853:MGAT1
gene id: 61853:MGAT1
uniprot id: G1QQ23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

61853:CLTA
gene id: 61853:CLTA
uniprot id: A0A2I3GS47
uniprot id: A0A2I3GXD2
uniprot id: A0A2I3H7X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

61853:STEAP4
gene id: 61853:STEAP4
uniprot id: A0A2I3HA22
uniprot id: G1RYN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

61853:HECTD1
gene id: 61853:HECTD1
uniprot id: G1S1H4
names: Function
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

61853:LGR5
gene id: 61853:LGR5
uniprot id: A0A2I3GFU9
uniprot id: A0A2I3GTX0
uniprot id: A0A2I3HQ88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:ATP5MC3
gene id: 61853:ATP5MC3
uniprot id: G1R202
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

61853:LOC100589053
gene id: 61853:LOC100589053
uniprot id: G1RXP9
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:CADM1
gene id: 61853:CADM1
uniprot id: A0A2I3FYE9
uniprot id: A0A2I3GYQ5
uniprot id: A0A2I3HGE9
names: Similarity
messages: Belongs to the nectin family.

61853:ATOH7
gene id: 61853:ATOH7
uniprot id: A0A2I3H6E9
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

61853:TRMT6
gene id: 61853:TRMT6
uniprot id: G1RUN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

61853:ADH7
gene id: 61853:ADH7
uniprot id: A0A2I3HQY5
uniprot id: G1RUC3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61853:SIGIRR
gene id: 61853:SIGIRR
uniprot id: G1R9Z2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61853:ATAD2B
gene id: 61853:ATAD2B
uniprot id: G1QIW9
names: Similarity
messages: Belongs to the AAA ATPase family.

61853:SAMM50
gene id: 61853:SAMM50
uniprot id: G1S0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

61853:FGD4
gene id: 61853:FGD4
uniprot id: A0A2I3HV53
names: Subcellular Location Annotation
messages: cytoskeleton

61853:F2RL2
gene id: 61853:F2RL2
uniprot id: G1RPZ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:PTGDR2
gene id: 61853:PTGDR2
uniprot id: A0A2I3HUA7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:CDR2
gene id: 61853:CDR2
uniprot id: G1RNA0
names: Similarity
messages: Belongs to the CDR2 family.

61853:TAP2
gene id: 61853:TAP2
uniprot id: A0A2I3GU35
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

61853:ANXA6
gene id: 61853:ANXA6
uniprot id: A0A2I3H0D8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

61853:TPRG1L
gene id: 61853:TPRG1L
uniprot id: A0A2I3GEA5
names: Similarity
messages: Belongs to the TPRG1 family.

61853:RPL26
gene id: 61853:RPL26
uniprot id: G1RG12
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61853:FSHB
gene id: 61853:FSHB
uniprot id: G1S872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

61853:GSDME
gene id: 61853:GSDME
uniprot id: G1RXU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61853:TMEM265
gene id: 61853:TMEM265
uniprot id: A0A2I3GUR7
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:PDIA3
gene id: 61853:PDIA3
uniprot id: G1R041
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

61853:BLOC1S3
gene id: 61853:BLOC1S3
uniprot id: G1S9W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BLOC1S3 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).
messages: Cytoplasm

61853:TSPAN31
gene id: 61853:TSPAN31
uniprot id: G1S5X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:GDPD2
gene id: 61853:GDPD2
uniprot id: G1QJL8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61853:STARD3NL
gene id: 61853:STARD3NL
uniprot id: A0A2I3H1B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61853:DUS3L
gene id: 61853:DUS3L
uniprot id: G1RTY5
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

61853:SEC22A
gene id: 61853:SEC22A
uniprot id: G1QHL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

61853:CEP63
gene id: 61853:CEP63
uniprot id: A0A2I3H4V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: centriolar satellite

61853:LOC100593203
gene id: 61853:LOC100593203
uniprot id: G1S9R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:NDEL1
gene id: 61853:NDEL1
uniprot id: A0A2I3HQP5
uniprot id: G1RG26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

61853:CLCA4
gene id: 61853:CLCA4
uniprot id: G1RGQ0
names: Similarity
messages: Belongs to the CLCR family.

61853:CCT8
gene id: 61853:CCT8
uniprot id: A0A2I3HE70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

61853:PGAP2
gene id: 61853:PGAP2
uniprot id: A0A2I3GZ91
uniprot id: A0A2I3H024
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PGAP2 family.
messages: Interacts with PGAP2IP.
messages: Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.
messages: Membrane

61853:PCLAF
gene id: 61853:PCLAF
uniprot id: A0A2I3GDK4
uniprot id: A0A2I3HEH3
names: Subcellular Location Annotation
messages: Nucleus
messages: perinuclear region

61853:PLPPR1
gene id: 61853:PLPPR1
uniprot id: A0A2I3G445
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

61853:RPL27A
gene id: 61853:RPL27A
uniprot id: G1S6Y9
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

61853:TIMM8A
gene id: 61853:TIMM8A
uniprot id: G1R7I5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61853:MIS12
gene id: 61853:MIS12
uniprot id: G1S9G9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

61853:TNMD
gene id: 61853:TNMD
uniprot id: G1R7F9
names: Similarity
messages: Belongs to the chondromodulin-1 family.

61853:CFAP299
gene id: 61853:CFAP299
uniprot id: A0A2I3H0W8
uniprot id: A0A2I3HPQ5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

61853:RNF2
gene id: 61853:RNF2
uniprot id: G1S8R3
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

61853:BORCS5
gene id: 61853:BORCS5
uniprot id: A0A2I3HR47
uniprot id: G1QTL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

61853:CD6
gene id: 61853:CD6
uniprot id: A0A2I3G8M9
uniprot id: A0A2I3GST4
uniprot id: A0A2I3H0Y2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CRISP1
gene id: 61853:CRISP1
uniprot id: A0A2I3HWX3
uniprot id: G1QV91
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SEMA3G
gene id: 61853:SEMA3G
uniprot id: G1R680
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SMIM18
gene id: 61853:SMIM18
uniprot id: G1SBS3
names: Subcellular Location Annotation
messages: Membrane

61853:TRHR
gene id: 61853:TRHR
uniprot id: G1QVZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

61853:DARS1
gene id: 61853:DARS1
uniprot id: A0A2I3GF22
names: Function
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

61853:SLU7
gene id: 61853:SLU7
uniprot id: A0A2I3I0I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

61853:SIX6
gene id: 61853:SIX6
uniprot id: G1RTW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

61853:RSPO2
gene id: 61853:RSPO2
uniprot id: G1QVK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

61853:QRFPR
gene id: 61853:QRFPR
uniprot id: A0A2I3GEB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:PPCS
gene id: 61853:PPCS
uniprot id: G1RNX6
names: Similarity
messages: Belongs to the PPC synthetase family.

61853:HOXD10
gene id: 61853:HOXD10
uniprot id: G1R249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61853:GLDN
gene id: 61853:GLDN
uniprot id: G1R3I4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LAMC1
gene id: 61853:LAMC1
uniprot id: G1S8P7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

61853:LOC100591611
gene id: 61853:LOC100591611
uniprot id: G1SAC4
names: Similarity
messages: Belongs to the pro/parathymosin family.

61853:PAX4
gene id: 61853:PAX4
uniprot id: A0A2I3GNE3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:NRCAM
gene id: 61853:NRCAM
uniprot id: A0A2I3GK07
uniprot id: A0A2I3HHY8
uniprot id: A0A2I3HN97
uniprot id: G1RAG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
messages: Membrane

61853:SEC24A
gene id: 61853:SEC24A
uniprot id: A0A2I3I0D0
uniprot id: G1R9P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61853:VTI1A
gene id: 61853:VTI1A
uniprot id: A0A2I3HV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

61853:GPR119
gene id: 61853:GPR119
uniprot id: G1S9Q0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:LOC100582195
gene id: 61853:LOC100582195
uniprot id: A0A1K0H3N2
names: Similarity
messages: Belongs to the globin family.

61853:CASP6
gene id: 61853:CASP6
uniprot id: G1S3N0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C14A family.
messages: Cytoplasm
messages: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
messages: Nucleus

61853:CDH11
gene id: 61853:CDH11
uniprot id: A0A2I3H3C5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:ITGA4
gene id: 61853:ITGA4
uniprot id: G1R393
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61853:PROK2
gene id: 61853:PROK2
uniprot id: A0A2I3HKU8
uniprot id: G1QQP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

61853:LOC100593132
gene id: 61853:LOC100593132
uniprot id: A0A2I3HBT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

61853:NUDT1
gene id: 61853:NUDT1
uniprot id: A0A2I3G317
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

61853:SGCZ
gene id: 61853:SGCZ
uniprot id: G1QNQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

61853:TPX2
gene id: 61853:TPX2
uniprot id: G1REX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

61853:MAEL
gene id: 61853:MAEL
uniprot id: A0A2I3GEV4
uniprot id: G1RXJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

61853:ERH
gene id: 61853:ERH
uniprot id: G1QLG4
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

61853:NDUFV3
gene id: 61853:NDUFV3
uniprot id: A0A2I3GI04
uniprot id: G1RX70
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.
messages: Belongs to the complex I NDUFV3 subunit family.
messages: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

61853:ELF2
gene id: 61853:ELF2
uniprot id: A0A2I3G750
uniprot id: A0A2I3GTY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61853:NCOA3
gene id: 61853:NCOA3
uniprot id: G1R5G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

61853:SLC39A5
gene id: 61853:SLC39A5
uniprot id: G1S6Y5
names: Subcellular Location Annotation
messages: Membrane

61853:SLC39A1
gene id: 61853:SLC39A1
uniprot id: A0A2I3HAJ3
names: Subcellular Location Annotation
messages: Membrane

61853:SLC9A4
gene id: 61853:SLC9A4
uniprot id: G1RX94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

61853:HOXC10
gene id: 61853:HOXC10
uniprot id: G1S7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61853:ALKAL1
gene id: 61853:ALKAL1
uniprot id: A0A2I3FW02
uniprot id: G1QJ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

61853:RAB21
gene id: 61853:RAB21
uniprot id: G1QWN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: neuron projection
messages: trans-Golgi network

61853:LOC100598804
gene id: 61853:LOC100598804
uniprot id: G1R7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

61853:PDE8A
gene id: 61853:PDE8A
uniprot id: G1RK33
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:ACER3
gene id: 61853:ACER3
uniprot id: A0A2I3HV55
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:LOC100581135
gene id: 61853:LOC100581135
uniprot id: A0A2I3HUK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

61853:ROCK2
gene id: 61853:ROCK2
uniprot id: A0A2I3GWR7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
messages: centrosome

61853:ADAT2
gene id: 61853:ADAT2
uniprot id: G1RYJ4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

61853:DKK4
gene id: 61853:DKK4
uniprot id: G1RQY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

61853:RIOK2
gene id: 61853:RIOK2
uniprot id: G1RWI7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

61853:ROR1
gene id: 61853:ROR1
uniprot id: G1RYM7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SLC9A2
gene id: 61853:SLC9A2
uniprot id: G1RXA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

61853:PYCR3
gene id: 61853:PYCR3
uniprot id: G1QNA2
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61853:DLAT
gene id: 61853:DLAT
uniprot id: G1R6S0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Mitochondrion matrix
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

61853:PDCL
gene id: 61853:PDCL
uniprot id: G1S5V1
names: Similarity
messages: Belongs to the phosducin family.

61853:TCTN1
gene id: 61853:TCTN1
uniprot id: A0A2I3H3P3
names: Similarity
names: Subunit
messages: Belongs to the tectonic family.
messages: Part of the tectonic-like complex (also named B9 complex).

61853:TPRKB
gene id: 61853:TPRKB
uniprot id: G1QHH7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

61853:MAP1LC3C
gene id: 61853:MAP1LC3C
uniprot id: G1QUJ5
names: Similarity
messages: Belongs to the ATG8 family.

61853:VIRMA
gene id: 61853:VIRMA
uniprot id: M3ZBE6
names: Similarity
messages: Belongs to the vir family.

61853:AP1S1
gene id: 61853:AP1S1
uniprot id: A0A2I3HF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

61853:AP1M1
gene id: 61853:AP1M1
uniprot id: A0A2I3GRJ3
uniprot id: G1R091
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Golgi apparatus
messages: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
messages: clathrin-coated vesicle membrane

61853:POLE2
gene id: 61853:POLE2
uniprot id: A0A2I3HR68
uniprot id: G1RN11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus
messages: Participates in DNA repair and in chromosomal DNA replication.

61853:TUBE1
gene id: 61853:TUBE1
uniprot id: G1RRA2
names: Similarity
messages: Belongs to the tubulin family.

61853:IZUMO1R
gene id: 61853:IZUMO1R
uniprot id: G1R639
names: Similarity
messages: Belongs to the folate receptor family.

61853:YIPF5
gene id: 61853:YIPF5
uniprot id: G1RFD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

61853:TSPAN6
gene id: 61853:TSPAN6
uniprot id: G1R7G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:OLFML1
gene id: 61853:OLFML1
uniprot id: G1S6T6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TMEM54
gene id: 61853:TMEM54
uniprot id: G1QS03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

61853:TOLLIP
gene id: 61853:TOLLIP
uniprot id: G1RRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

61853:DPH3
gene id: 61853:DPH3
uniprot id: A0A2I3FWQ7
uniprot id: A0A2I3GTW2
names: Similarity
messages: Belongs to the DPH3 family.

61853:BEST3
gene id: 61853:BEST3
uniprot id: A0A2I3GBC9
uniprot id: A0A2I3H7E5
uniprot id: G1QV48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bestrophin family.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

61853:CCNH
gene id: 61853:CCNH
uniprot id: A0A2I3HFR1
uniprot id: G1RTE2
names: Function
names: Similarity
names: Subunit
messages: Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.
messages: Belongs to the cyclin family.
messages: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

61853:RPAIN
gene id: 61853:RPAIN
uniprot id: A0A2I3HY77
uniprot id: G1RCV2
names: Subcellular Location Annotation
messages: Nucleus

61853:ZBED1
gene id: 61853:ZBED1
uniprot id: G1SAQ9
names: Subcellular Location Annotation
messages: Nucleus

61853:TXLNB
gene id: 61853:TXLNB
uniprot id: G1RYF8
names: Similarity
messages: Belongs to the taxilin family.

61853:IREB2
gene id: 61853:IREB2
uniprot id: G1RBD6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Cytoplasm
messages: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

61853:PDYN
gene id: 61853:PDYN
uniprot id: G1RDL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
messages: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
messages: Secreted

61853:IL16
gene id: 61853:IL16
uniprot id: G1QL12
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
messages: Nucleus
messages: Secreted

61853:PLSCR4
gene id: 61853:PLSCR4
uniprot id: G1QYW2
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61853:CTNS
gene id: 61853:CTNS
uniprot id: G1S613
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

61853:LOC100601292
gene id: 61853:LOC100601292
uniprot id: G1SC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SLC35B3
gene id: 61853:SLC35B3
uniprot id: A0A2I3G7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

61853:ZP1
gene id: 61853:ZP1
uniprot id: G1RTB0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZP domain family. ZPB subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Zona pellucida

61853:ACSM4
gene id: 61853:ACSM4
uniprot id: G1QZH3
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61853:HBS1L
gene id: 61853:HBS1L
uniprot id: A0A2I3HA64
uniprot id: G1RXF4
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Interacts with the SKI complex.

61853:EMC2
gene id: 61853:EMC2
uniprot id: A0A2I3HKT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

61853:AHSA1
gene id: 61853:AHSA1
uniprot id: A0A2I3GPB5
names: Similarity
messages: Belongs to the AHA1 family.

61853:SETD7
gene id: 61853:SETD7
uniprot id: A0A2I3HBF0
uniprot id: A0A2I3HJB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

61853:CHGA
gene id: 61853:CHGA
uniprot id: G1S5U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

61853:PTPRB
gene id: 61853:PTPRB
uniprot id: A0A2I3H359
uniprot id: A0A2I3H419
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

61853:GUK1
gene id: 61853:GUK1
uniprot id: A0A2I3HAA0
uniprot id: A0A2I3HW40
names: Similarity
messages: Belongs to the guanylate kinase family.

61853:CARM1
gene id: 61853:CARM1
uniprot id: G1RP73
names: Subcellular Location Annotation
messages: Nucleus

61853:APH1A
gene id: 61853:APH1A
uniprot id: G1RFG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

61853:LOC100602058
gene id: 61853:LOC100602058
uniprot id: A0A2I3HJM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61853:SPDYE4
gene id: 61853:SPDYE4
uniprot id: G1RG73
names: Similarity
messages: Belongs to the Speedy/Ringo family.

61853:FAM162A
gene id: 61853:FAM162A
uniprot id: G1QHF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

61853:PLAUR
gene id: 61853:PLAUR
uniprot id: A0A2I3G334
uniprot id: G1QMB3
names: Function
names: Subcellular Location Annotation
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
messages: Cell membrane
messages: Membrane
messages: invadopodium membrane

61853:FGB
gene id: 61853:FGB
uniprot id: G1R2J2
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

61853:TMEM33
gene id: 61853:TMEM33
uniprot id: G1S5Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

61853:FLVCR1
gene id: 61853:FLVCR1
uniprot id: G1RWS7
names: Subcellular Location Annotation
messages: Membrane

61853:CMC2
gene id: 61853:CMC2
uniprot id: G1RHJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

61853:LOC100593944
gene id: 61853:LOC100593944
uniprot id: G1S7K4
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:LOC100596044
gene id: 61853:LOC100596044
uniprot id: G1S9J5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:CPEB3
gene id: 61853:CPEB3
uniprot id: A0A2I3HEM5
uniprot id: G1RPZ7
names: Similarity
messages: Belongs to the RRM CPEB family.

61853:HAT1
gene id: 61853:HAT1
uniprot id: A0A2I3GP06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

61853:CDCA7
gene id: 61853:CDCA7
uniprot id: A0A2I3H6C9
uniprot id: G1R1G1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:GLRX
gene id: 61853:GLRX
uniprot id: G1RVE4
names: Function
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

61853:DBR1
gene id: 61853:DBR1
uniprot id: A0A2I3HQ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

61853:IFNW1
gene id: 61853:IFNW1
uniprot id: A0A7R8C4W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:SEPTIN11
gene id: 61853:SEPTIN11
uniprot id: A0A2I3G5C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61853:CYFIP2
gene id: 61853:CYFIP2
uniprot id: A0A2I3GCB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

61853:MEOX2
gene id: 61853:MEOX2
uniprot id: G1S2X0
names: Subcellular Location Annotation
messages: Nucleus

61853:PGP
gene id: 61853:PGP
uniprot id: A0A2I3GC63
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

61853:LOC100606450
gene id: 61853:LOC100606450
uniprot id: A0A2I3G1C6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:LOC100587005
gene id: 61853:LOC100587005
uniprot id: G1R9Y0
names: Similarity
messages: Belongs to the GAGE family.

61853:NUBP2
gene id: 61853:NUBP2
uniprot id: G1RBW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

61853:SMARCA5
gene id: 61853:SMARCA5
uniprot id: A0A2I3HBQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

61853:VARS1
gene id: 61853:VARS1
uniprot id: G1R3G6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61853:HARS1
gene id: 61853:HARS1
uniprot id: A0A2I3GM82
uniprot id: A0A2I3HLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

61853:RGS2
gene id: 61853:RGS2
uniprot id: G1S8T4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: nucleolus

61853:TLR3
gene id: 61853:TLR3
uniprot id: G1RKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61853:P4HA3
gene id: 61853:P4HA3
uniprot id: G1S595
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61853:STARD6
gene id: 61853:STARD6
uniprot id: G1RMN0
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

61853:DPPA5
gene id: 61853:DPPA5
uniprot id: G1QKG6
names: Similarity
messages: Belongs to the KHDC1 family.

61853:CLDN15
gene id: 61853:CLDN15
uniprot id: G1RA19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:CNEP1R1
gene id: 61853:CNEP1R1
uniprot id: A0A2I3H753
uniprot id: A0A2I3HQ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

61853:MAP3K11
gene id: 61853:MAP3K11
uniprot id: G1R178
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

61853:AHCYL2
gene id: 61853:AHCYL2
uniprot id: A0A2I3HAP3
uniprot id: A0A2I3HL28
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

61853:GSK3B
gene id: 61853:GSK3B
uniprot id: A0A2I3GEZ5
uniprot id: G1QYY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

61853:ANP32E
gene id: 61853:ANP32E
uniprot id: A0A2I3HV86
names: Similarity
messages: Belongs to the ANP32 family.

61853:PNO1
gene id: 61853:PNO1
uniprot id: A0A2I3H5E8
names: Similarity
messages: Belongs to the PNO1 family.

61853:RNF146
gene id: 61853:RNF146
uniprot id: G1RV88
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

61853:MAX
gene id: 61853:MAX
uniprot id: A0A2I3H4F8
uniprot id: A0A2I3H6F7
uniprot id: A0A2I3H850
uniprot id: G1RW72
names: Similarity
messages: Belongs to the MAX family.

61853:SSTR4
gene id: 61853:SSTR4
uniprot id: G1SAH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:EFNB1
gene id: 61853:EFNB1
uniprot id: G1QIU1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:MITF
gene id: 61853:MITF
uniprot id: A0A2I3GJ87
uniprot id: A0A2I3HVZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61853:NUSAP1
gene id: 61853:NUSAP1
uniprot id: G1QTQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUSAP family.
messages: Cytoplasm

61853:TMEM35B
gene id: 61853:TMEM35B
uniprot id: G1QTI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

61853:AVL9
gene id: 61853:AVL9
uniprot id: A0A2I3GG82
uniprot id: A0A2I3GWC6
names: Subcellular Location Annotation
messages: Endosome
messages: Recycling endosome

61853:SLC25A45
gene id: 61853:SLC25A45
uniprot id: A0A2I3G1U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:MAML3
gene id: 61853:MAML3
uniprot id: G1QYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

61853:DBT
gene id: 61853:DBT
uniprot id: G1RM86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61853:VPS4B
gene id: 61853:VPS4B
uniprot id: A0A2I3GU19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61853:LOC100605123
gene id: 61853:LOC100605123
uniprot id: G1QJQ1
names: Subcellular Location Annotation
messages: Membrane

61853:TEKT1
gene id: 61853:TEKT1
uniprot id: G1RDP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61853:UBP1
gene id: 61853:UBP1
uniprot id: A0A2I3GVW1
uniprot id: G1QXJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61853:PON1
gene id: 61853:PON1
uniprot id: G1S0R9
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

61853:MINDY2
gene id: 61853:MINDY2
uniprot id: G1RKZ4
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

61853:BFSP1
gene id: 61853:BFSP1
uniprot id: A0A2I3GPY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

61853:GGPS1
gene id: 61853:GGPS1
uniprot id: G1QR51
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61853:HEATR5A
gene id: 61853:HEATR5A
uniprot id: G1S1P3
names: Similarity
messages: Belongs to the HEATR5 family.

61853:HCAR1
gene id: 61853:HCAR1
uniprot id: A0A4Y1JWR7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:SESN1
gene id: 61853:SESN1
uniprot id: A0A2I3H4T0
uniprot id: G1RPL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

61853:TMEM35A
gene id: 61853:TMEM35A
uniprot id: G1R7H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

61853:PCNP
gene id: 61853:PCNP
uniprot id: A0A2I3GYR5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

61853:GOLT1B
gene id: 61853:GOLT1B
uniprot id: A0A2I3GRJ1
uniprot id: G1QY33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

61853:ZKSCAN8
gene id: 61853:ZKSCAN8
uniprot id: A0A2I3HWF0
names: Subcellular Location Annotation
messages: Nucleus

61853:AOX1
gene id: 61853:AOX1
uniprot id: A0A2I3GID8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

61853:RPL37
gene id: 61853:RPL37
uniprot id: A0A2I3GWN4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61853:SULT1B1
gene id: 61853:SULT1B1
uniprot id: G1R7W4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61853:LRRC8A
gene id: 61853:LRRC8A
uniprot id: G1S7B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

61853:PRDM1
gene id: 61853:PRDM1
uniprot id: A0A2I3GKR4
uniprot id: G1RS40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

61853:BLOC1S5
gene id: 61853:BLOC1S5
uniprot id: A0A2I3GSF6
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

61853:PCYT1B
gene id: 61853:PCYT1B
uniprot id: A0A2I3H1F8
uniprot id: A0A2I3HGH6
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

61853:MPPED2
gene id: 61853:MPPED2
uniprot id: G1S874
names: Similarity
messages: Belongs to the UPF0046 family.

61853:COQ10B
gene id: 61853:COQ10B
uniprot id: A0A2I3GES0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

61853:ZRANB2
gene id: 61853:ZRANB2
uniprot id: A0A2I3G9J6
uniprot id: G1RE58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

61853:GDI1
gene id: 61853:GDI1
uniprot id: G1RVP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

61853:ATF4
gene id: 61853:ATF4
uniprot id: G1RZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

61853:TRMU
gene id: 61853:TRMU
uniprot id: A0A2I3GEY8
uniprot id: G1S0U6
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

61853:IRF6
gene id: 61853:IRF6
uniprot id: A0A2I3GRU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:CSMD3
gene id: 61853:CSMD3
uniprot id: G1QXV3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TBCCD1
gene id: 61853:TBCCD1
uniprot id: G1R453
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

61853:PDE5A
gene id: 61853:PDE5A
uniprot id: G1RCW7
uniprot id: G1RCW9
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:BAZ1B
gene id: 61853:BAZ1B
uniprot id: G1RCG7
names: Subcellular Location Annotation
messages: Nucleus

61853:PRAMEF19
gene id: 61853:PRAMEF19
uniprot id: G1RFN2
names: Similarity
messages: Belongs to the PRAME family.

61853:SPAM1
gene id: 61853:SPAM1
uniprot id: G1RNI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

61853:CACNG5
gene id: 61853:CACNG5
uniprot id: G1QHB8
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

61853:CCK
gene id: 61853:CCK
uniprot id: G1R1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

61853:TXLNA
gene id: 61853:TXLNA
uniprot id: G1QPJ4
names: Similarity
messages: Belongs to the taxilin family.

61853:HAPLN1
gene id: 61853:HAPLN1
uniprot id: G1RSL0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CD34
gene id: 61853:CD34
uniprot id: G1QL96
names: Subcellular Location Annotation
messages: Membrane

61853:CCL28
gene id: 61853:CCL28
uniprot id: G1RHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61853:AQP2
gene id: 61853:AQP2
uniprot id: G1S800
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61853:PTAFR
gene id: 61853:PTAFR
uniprot id: G1RF84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane
messages: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

61853:FAM122B
gene id: 61853:FAM122B
uniprot id: A0A2I3H8A5
names: Similarity
messages: Belongs to the FAM122 family.

61853:WDR91
gene id: 61853:WDR91
uniprot id: G1RSC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61853:TEKT2
gene id: 61853:TEKT2
uniprot id: G1RKB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61853:IL5RA
gene id: 61853:IL5RA
uniprot id: G1QSI2
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

61853:ODF2L
gene id: 61853:ODF2L
uniprot id: G1RGK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

61853:CLUAP1
gene id: 61853:CLUAP1
uniprot id: A0A2I3HX61
uniprot id: G1REX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

61853:AP4M1
gene id: 61853:AP4M1
uniprot id: G1RLB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
messages: Early endosome
messages: trans-Golgi network membrane

61853:ZFP36L1
gene id: 61853:ZFP36L1
uniprot id: G1QJY0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

61853:GLRB
gene id: 61853:GLRB
uniprot id: A0A2I3HSM1
uniprot id: G1R388
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:OST4
gene id: 61853:OST4
uniprot id: A0A2I3GRX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:LOC100579760
gene id: 61853:LOC100579760
uniprot id: G1S976
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:RPS19BP1
gene id: 61853:RPS19BP1
uniprot id: A0A2I3I037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

61853:CXCR3
gene id: 61853:CXCR3
uniprot id: G1QK64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homomer. Forms heteromers with ACKR4.
messages: Membrane

61853:METTL14
gene id: 61853:METTL14
uniprot id: G1RC99
names: Similarity
messages: Belongs to the MT-A70-like family.

61853:CD93
gene id: 61853:CD93
uniprot id: G1RLD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:IL18RAP
gene id: 61853:IL18RAP
uniprot id: G1RX82
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61853:DOLPP1
gene id: 61853:DOLPP1
uniprot id: A0A2I3GV95
uniprot id: G1S7B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

61853:ST7L
gene id: 61853:ST7L
uniprot id: G1QVT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

61853:RNF168
gene id: 61853:RNF168
uniprot id: G1QLL3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

61853:TRMT5
gene id: 61853:TRMT5
uniprot id: A0A2I3GXC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

61853:INTS10
gene id: 61853:INTS10
uniprot id: G1QSW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

61853:LPAR1
gene id: 61853:LPAR1
uniprot id: G1S6S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

61853:LZIC
gene id: 61853:LZIC
uniprot id: G1RDW0
names: Similarity
messages: Belongs to the CTNNBIP1 family.

61853:ABCG5
gene id: 61853:ABCG5
uniprot id: G1S4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61853:GAPDHS
gene id: 61853:GAPDHS
uniprot id: G1RK80
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

61853:POC5
gene id: 61853:POC5
uniprot id: A0A2I3HAH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

61853:PSMB9
gene id: 61853:PSMB9
uniprot id: G1R4W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61853:ACE2
gene id: 61853:ACE2
uniprot id: G1RE79
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

61853:SCFD2
gene id: 61853:SCFD2
uniprot id: A0A2I3G7B4
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61853:LOC100605034
gene id: 61853:LOC100605034
uniprot id: A0A2I3H5G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:CLDN3
gene id: 61853:CLDN3
uniprot id: A0A2I3HKP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61853:FLAD1
gene id: 61853:FLAD1
uniprot id: G1RLG1
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

61853:LOC100598207
gene id: 61853:LOC100598207
uniprot id: A0A2I3GR54
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

61853:POU1F1
gene id: 61853:POU1F1
uniprot id: G1RM38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

61853:KREMEN1
gene id: 61853:KREMEN1
uniprot id: G1QQB8
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

61853:LRP6
gene id: 61853:LRP6
uniprot id: G1QTL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:SLC28A3
gene id: 61853:SLC28A3
uniprot id: G1QU00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

61853:GUCY2C
gene id: 61853:GUCY2C
uniprot id: G1QUW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

61853:TACC2
gene id: 61853:TACC2
uniprot id: A0A2I3FQS7
uniprot id: A0A2I3GSL0
uniprot id: A0A2I3GVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

61853:ZCCHC4
gene id: 61853:ZCCHC4
uniprot id: G1S4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

61853:NSUN3
gene id: 61853:NSUN3
uniprot id: A0A2I3GGT8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61853:IL15
gene id: 61853:IL15
uniprot id: G1QZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

61853:RAB9A
gene id: 61853:RAB9A
uniprot id: A0A2I3G0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: phagosome membrane

61853:B3GNT5
gene id: 61853:B3GNT5
uniprot id: G1SBB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61853:PSMC4
gene id: 61853:PSMC4
uniprot id: A0A2I3HCV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

61853:NDUFA12
gene id: 61853:NDUFA12
uniprot id: G1R1B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61853:ORM1
gene id: 61853:ORM1
uniprot id: G1S4I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Functions as transport protein in the blood stream.
messages: Secreted

61853:NR4A2
gene id: 61853:NR4A2
uniprot id: G1QIL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

61853:CCS
gene id: 61853:CCS
uniprot id: A0A2I3GTU8
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

61853:LOC100605934
gene id: 61853:LOC100605934
uniprot id: G1RIZ1
names: Similarity
messages: Belongs to the aldo/keto reductase family.

61853:FAM234A
gene id: 61853:FAM234A
uniprot id: G1R988
names: Similarity
messages: Belongs to the FAM234 family.

61853:KIFC1
gene id: 61853:KIFC1
uniprot id: G1RA63
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61853:E2F2
gene id: 61853:E2F2
uniprot id: G1RB57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61853:STX19
gene id: 61853:STX19
uniprot id: G1QMZ1
names: Similarity
messages: Belongs to the syntaxin family.

61853:ZDHHC17
gene id: 61853:ZDHHC17
uniprot id: G1QY94
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:MRPS18C
gene id: 61853:MRPS18C
uniprot id: A0A2I3GX69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

61853:SLC25A51
gene id: 61853:SLC25A51
uniprot id: A0A2I3HZZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:FAM229B
gene id: 61853:FAM229B
uniprot id: G1RRA5
names: Similarity
messages: Belongs to the FAM229 family.

61853:CASP1
gene id: 61853:CASP1
uniprot id: A0A2I3GQA0
names: Similarity
messages: Belongs to the peptidase C14A family.

61853:REM1
gene id: 61853:REM1
uniprot id: G1REL0
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61853:SGTB
gene id: 61853:SGTB
uniprot id: G1QTU5
names: Similarity
messages: Belongs to the SGT family.

61853:C3AR1
gene id: 61853:C3AR1
uniprot id: G1QMA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

61853:ATP6V1G1
gene id: 61853:ATP6V1G1
uniprot id: G1S4K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61853:TBK1
gene id: 61853:TBK1
uniprot id: G1S5B9
names: Subcellular Location Annotation
messages: Cytoplasm

61853:MCM7
gene id: 61853:MCM7
uniprot id: G1RL67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

61853:PIGL
gene id: 61853:PIGL
uniprot id: A0A2I3G1X8
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

61853:GALNT15
gene id: 61853:GALNT15
uniprot id: A0A2I3HYT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61853:TLR10
gene id: 61853:TLR10
uniprot id: G1S5C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61853:GHRL
gene id: 61853:GHRL
uniprot id: G1QWU2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

61853:NF2
gene id: 61853:NF2
uniprot id: A0A2I3FXA5
uniprot id: G1QT29
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61853:SLC24A4
gene id: 61853:SLC24A4
uniprot id: G1S5Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

61853:EFHB
gene id: 61853:EFHB
uniprot id: G1QT81
names: Subcellular Location Annotation
messages: cilium axoneme

61853:TRIM9
gene id: 61853:TRIM9
uniprot id: A0A2I3HE46
uniprot id: G1RP32
names: Subcellular Location Annotation
messages: cytoskeleton

61853:UBE2E1
gene id: 61853:UBE2E1
uniprot id: G1QTP2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61853:LOC100605186
gene id: 61853:LOC100605186
uniprot id: A0A2I3GRT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).
messages: Membrane
messages: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

61853:UTS2R
gene id: 61853:UTS2R
uniprot id: G1SAZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

61853:CACNB4
gene id: 61853:CACNB4
uniprot id: A0A2I3GDT9
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

61853:BOLA3
gene id: 61853:BOLA3
uniprot id: A0A2I3FXI5
names: Similarity
messages: Belongs to the BolA/IbaG family.

61853:CRHBP
gene id: 61853:CRHBP
uniprot id: G1RQ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

61853:LRP3
gene id: 61853:LRP3
uniprot id: G1R808
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TMEM177
gene id: 61853:TMEM177
uniprot id: A0A2I3HIU8
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

61853:PSME1
gene id: 61853:PSME1
uniprot id: A0A2I3GLV9
names: Similarity
messages: Belongs to the PA28 family.

61853:SPC25
gene id: 61853:SPC25
uniprot id: G1QXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

61853:FAM49B
gene id: 61853:FAM49B
uniprot id: G1R0Q1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

61853:HMBOX1
gene id: 61853:HMBOX1
uniprot id: A0A2I3HX23
names: Subcellular Location Annotation
messages: Nucleus

61853:CORO6
gene id: 61853:CORO6
uniprot id: G1QTL6
names: Similarity
messages: Belongs to the WD repeat coronin family.

61853:ERN1
gene id: 61853:ERN1
uniprot id: G1RYK6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:NFXL1
gene id: 61853:NFXL1
uniprot id: G1S6E2
names: Similarity
messages: Belongs to the NFX1 family.

61853:DLL1
gene id: 61853:DLL1
uniprot id: G1QHD7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

61853:MED20
gene id: 61853:MED20
uniprot id: A0A2I3G1W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61853:LOC100589443
gene id: 61853:LOC100589443
uniprot id: A0A2I3FVV7
uniprot id: G1RSV4
names: Similarity
messages: Belongs to the MS4A family.

61853:ATP2C2
gene id: 61853:ATP2C2
uniprot id: A0A2I3GBS3
uniprot id: G1RK62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:ABL2
gene id: 61853:ABL2
uniprot id: A0A2I3GSM6
uniprot id: G1S0A6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61853:AMD1
gene id: 61853:AMD1
uniprot id: G1RQS4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

61853:HOOK3
gene id: 61853:HOOK3
uniprot id: A0A2I3G802
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

61853:LEAP2
gene id: 61853:LEAP2
uniprot id: G1RQW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

61853:PCOLCE2
gene id: 61853:PCOLCE2
uniprot id: G1QYC7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:DCST2
gene id: 61853:DCST2
uniprot id: G1RLK0
names: Subcellular Location Annotation
messages: Membrane

61853:NFKB1
gene id: 61853:NFKB1
uniprot id: G1RSM4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61853:RNF167
gene id: 61853:RNF167
uniprot id: G1S6M6
names: Subcellular Location Annotation
messages: Membrane

61853:NSF
gene id: 61853:NSF
uniprot id: A0A2I3G312
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

61853:PPT2
gene id: 61853:PPT2
uniprot id: G1R488
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palmitoyl-protein thioesterase family.
messages: Lysosome

61853:TAPT1
gene id: 61853:TAPT1
uniprot id: G1S3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

61853:WDR76
gene id: 61853:WDR76
uniprot id: G1R0E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Interacts with CUL4A and/or CUL4B.
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

61853:TMEM229B
gene id: 61853:TMEM229B
uniprot id: A0A2I3HZP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

61853:CRHR2
gene id: 61853:CRHR2
uniprot id: A0A2I3GBM1
uniprot id: G1RYV7
uniprot id: G1RYV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

61853:LOC100594622
gene id: 61853:LOC100594622
uniprot id: G1S5V0
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:VDAC3
gene id: 61853:VDAC3
uniprot id: A0A2I3GKR5
uniprot id: G1RR08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

61853:CEMIP2
gene id: 61853:CEMIP2
uniprot id: G1QJU1
names: Similarity
messages: Belongs to the CEMIP family.

61853:GOLPH3
gene id: 61853:GOLPH3
uniprot id: A0A2I3G6G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

61853:DHODH
gene id: 61853:DHODH
uniprot id: A0A2I3GMK8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

61853:LIAS
gene id: 61853:LIAS
uniprot id: A0A2I3GEA2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

61853:MRAP2
gene id: 61853:MRAP2
uniprot id: G1RQH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRAP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:CENPU
gene id: 61853:CENPU
uniprot id: G1RJI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-U/AME1 family.
messages: Nucleus

61853:LOC100606517
gene id: 61853:LOC100606517
uniprot id: G1SBV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SCFD1
gene id: 61853:SCFD1
uniprot id: G1S109
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61853:PLEKHA8
gene id: 61853:PLEKHA8
uniprot id: A0A2I3HRS6
names: Subcellular Location Annotation
messages: Membrane
messages: trans-Golgi network membrane

61853:NIPAL3
gene id: 61853:NIPAL3
uniprot id: A0A2I3GM75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61853:CNNM4
gene id: 61853:CNNM4
uniprot id: G1R8E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

61853:FGF5
gene id: 61853:FGF5
uniprot id: G1RAW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
messages: Secreted

61853:SLC5A7
gene id: 61853:SLC5A7
uniprot id: G1RIZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61853:LOC100606669
gene id: 61853:LOC100606669
uniprot id: A0A2I3GFC1
names: Similarity
messages: Belongs to the COX20 family.

61853:B9D1
gene id: 61853:B9D1
uniprot id: G1RBT5
names: Subcellular Location Annotation
messages: cilium basal body

61853:GRHL2
gene id: 61853:GRHL2
uniprot id: G1QSX7
names: Subcellular Location Annotation
messages: Nucleus

61853:GPNMB
gene id: 61853:GPNMB
uniprot id: G1RXI4
names: Similarity
messages: Belongs to the PMEL/NMB family.

61853:FAM161A
gene id: 61853:FAM161A
uniprot id: A0A2I3HVZ5
uniprot id: G1RF22
names: Similarity
messages: Belongs to the FAM161 family.

61853:PRDM5
gene id: 61853:PRDM5
uniprot id: A0A2I3HCG9
uniprot id: A0A2I3HGA7
uniprot id: G1RD15
names: Subcellular Location Annotation
messages: Nucleus

61853:RAB3IL1
gene id: 61853:RAB3IL1
uniprot id: G1QSN9
names: Similarity
messages: Belongs to the SEC2 family.

61853:DOCK2
gene id: 61853:DOCK2
uniprot id: G1QZ10
names: Similarity
messages: Belongs to the DOCK family.

61853:ZDHHC2
gene id: 61853:ZDHHC2
uniprot id: G1QPY3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:BANF2
gene id: 61853:BANF2
uniprot id: G1RF11
names: Subcellular Location Annotation
messages: Nucleus

61853:CES5A
gene id: 61853:CES5A
uniprot id: A0A2I3I0C8
uniprot id: G1QMJ9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

61853:GAR1
gene id: 61853:GAR1
uniprot id: G1S3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

61853:CRYBA1
gene id: 61853:CRYBA1
uniprot id: G1QSR4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61853:SUB1
gene id: 61853:SUB1
uniprot id: A0A2I3GIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

61853:SUPT3H
gene id: 61853:SUPT3H
uniprot id: A0A2I3HJM7
names: Subcellular Location Annotation
messages: Nucleus

61853:CCT6A
gene id: 61853:CCT6A
uniprot id: A0A2I3H249
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

61853:TCN1
gene id: 61853:TCN1
uniprot id: G1RRV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

61853:CNDP1
gene id: 61853:CNDP1
uniprot id: G1RDM3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

61853:RPL35
gene id: 61853:RPL35
uniprot id: A0A2I3GH94
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

61853:LOC100598111
gene id: 61853:LOC100598111
uniprot id: A0A2I3HY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space

61853:PGGT1B
gene id: 61853:PGGT1B
uniprot id: G1RM16
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

61853:ENTPD5
gene id: 61853:ENTPD5
uniprot id: G1S264
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61853:HBP1
gene id: 61853:HBP1
uniprot id: G1RBX7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

61853:COPS7B
gene id: 61853:COPS7B
uniprot id: A0A2I3H3Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

61853:RPL13
gene id: 61853:RPL13
uniprot id: A0A2I3GGJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

61853:IL6
gene id: 61853:IL6
uniprot id: G1S4D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

61853:CAST
gene id: 61853:CAST
uniprot id: A0A2I3GGL8
uniprot id: A0A2I3GRS9
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

61853:CPA5
gene id: 61853:CPA5
uniprot id: A0A2I3GYV0
uniprot id: G1RQM4
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:HHAT
gene id: 61853:HHAT
uniprot id: A0A2I3GE49
uniprot id: A0A2I3HK24
uniprot id: G1QPJ0
names: Subcellular Location Annotation
messages: Membrane

61853:NUP62CL
gene id: 61853:NUP62CL
uniprot id: G1RUB9
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

61853:VHL
gene id: 61853:VHL
uniprot id: G1QWL9
names: Similarity
messages: Belongs to the VHL family.

61853:GTF2H4
gene id: 61853:GTF2H4
uniprot id: G1R0S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

61853:USP11
gene id: 61853:USP11
uniprot id: A0A2I3G364
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

61853:PSEN1
gene id: 61853:PSEN1
uniprot id: G1QRH5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

61853:PSMD7
gene id: 61853:PSMD7
uniprot id: A0A2I3GQ47
names: Similarity
messages: Belongs to the peptidase M67A family.

61853:LOC100596946
gene id: 61853:LOC100596946
uniprot id: A0A2I3HH18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61853:MRPL13
gene id: 61853:MRPL13
uniprot id: A0A2I3GDU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

61853:NTS
gene id: 61853:NTS
uniprot id: G1R004
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

61853:TRAF5
gene id: 61853:TRAF5
uniprot id: G1QQ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

61853:CDC42EP3
gene id: 61853:CDC42EP3
uniprot id: A0A2I3H8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

61853:SVBP
gene id: 61853:SVBP
uniprot id: G1RP16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

61853:ARPC4
gene id: 61853:ARPC4
uniprot id: G1QVW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

61853:ATP6
gene id: 61853:ATP6
uniprot id: E7EAF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

61853:PIR
gene id: 61853:PIR
uniprot id: G1RDY1
names: Similarity
messages: Belongs to the pirin family.

61853:METTL26
gene id: 61853:METTL26
uniprot id: A0A2I3GJP8
uniprot id: A0A2I3H6D0
uniprot id: G1R9K0
names: Similarity
messages: Belongs to the UPF0585 family.

61853:OTC
gene id: 61853:OTC
uniprot id: G1QKJ1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

61853:DEGS2
gene id: 61853:DEGS2
uniprot id: G1QJS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:HMCES
gene id: 61853:HMCES
uniprot id: A0A2I3GTI7
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

61853:EBAG9
gene id: 61853:EBAG9
uniprot id: A0A2I3HUX3
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

61853:AZIN1
gene id: 61853:AZIN1
uniprot id: G1QU14
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

61853:TIMM8B
gene id: 61853:TIMM8B
uniprot id: A0A2I3GMG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61853:ATF1
gene id: 61853:ATF1
uniprot id: G1S7W8
names: Subcellular Location Annotation
messages: Nucleus

61853:CORO1A
gene id: 61853:CORO1A
uniprot id: A0A2I3GI37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

61853:RNF152
gene id: 61853:RNF152
uniprot id: A0A2I3HSF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

61853:DUSP10
gene id: 61853:DUSP10
uniprot id: A0A2I3HVQ2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61853:TXNL4B
gene id: 61853:TXNL4B
uniprot id: G1R118
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

61853:AMBN
gene id: 61853:AMBN
uniprot id: G1R841
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ameloblastin family.
messages: Involved in the mineralization and structural organization of enamel.
messages: extracellular matrix

61853:LSM3
gene id: 61853:LSM3
uniprot id: G1QYX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

61853:HOXA9
gene id: 61853:HOXA9
uniprot id: G1RY99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

61853:SEMA5A
gene id: 61853:SEMA5A
uniprot id: G1RLH1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:SPTLC2
gene id: 61853:SPTLC2
uniprot id: A0A2I3HUF9
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

61853:MAGOHB
gene id: 61853:MAGOHB
uniprot id: G1QT10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

61853:RPS10
gene id: 61853:RPS10
uniprot id: A0A2I3GDB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

61853:AADACL2
gene id: 61853:AADACL2
uniprot id: G1QTJ4
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61853:MINDY3
gene id: 61853:MINDY3
uniprot id: G1RPC6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

61853:CENPA
gene id: 61853:CENPA
uniprot id: A0A2I3FZD0
uniprot id: A0A2I3HX91
names: Similarity
messages: Belongs to the histone H3 family.

61853:SLC30A10
gene id: 61853:SLC30A10
uniprot id: G1RV68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61853:CPNE8
gene id: 61853:CPNE8
uniprot id: A0A2I3HW93
names: Similarity
messages: Belongs to the copine family.

61853:SEH1L
gene id: 61853:SEH1L
uniprot id: G1RCZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

61853:ANO10
gene id: 61853:ANO10
uniprot id: G1R1T1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:DRGX
gene id: 61853:DRGX
uniprot id: A0A2I3H9V9
names: Subcellular Location Annotation
messages: Nucleus

61853:ESCO1
gene id: 61853:ESCO1
uniprot id: G1R536
names: Subcellular Location Annotation
messages: Nucleus

61853:HACD1
gene id: 61853:HACD1
uniprot id: A0A2I3HH69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:WDR82
gene id: 61853:WDR82
uniprot id: G1R634
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

61853:TACR3
gene id: 61853:TACR3
uniprot id: G1RSA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:HPX
gene id: 61853:HPX
uniprot id: G1S6J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hemopexin family.
messages: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
messages: Secreted

61853:LOC100584815
gene id: 61853:LOC100584815
uniprot id: A0A2I3H952
uniprot id: G1RHA4
names: Similarity
messages: Belongs to the cytochrome P450 family.

61853:GPN2
gene id: 61853:GPN2
uniprot id: G1RDX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

61853:TRIAP1
gene id: 61853:TRIAP1
uniprot id: G1S0E4
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

61853:FAM98B
gene id: 61853:FAM98B
uniprot id: A0A2I3GIR7
names: Similarity
messages: Belongs to the FAM98 family.

61853:CHST3
gene id: 61853:CHST3
uniprot id: G1S2X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61853:ARHGEF3
gene id: 61853:ARHGEF3
uniprot id: A0A2I3H776
uniprot id: A0A2I3HMM0
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

61853:FFAR2
gene id: 61853:FFAR2
uniprot id: A0A2I3HE13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:LOC100595785
gene id: 61853:LOC100595785
uniprot id: A0A2I3G3E0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61853:ENTPD7
gene id: 61853:ENTPD7
uniprot id: A0A2I3HI29
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61853:ARL8B
gene id: 61853:ARL8B
uniprot id: A0A2I3H2M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Synapse
messages: axon
messages: spindle

61853:COG1
gene id: 61853:COG1
uniprot id: A0A2I3GL12
names: Similarity
messages: Belongs to the COG1 family.

61853:ORAI3
gene id: 61853:ORAI3
uniprot id: A0A2I3G9U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

61853:PDK1
gene id: 61853:PDK1
uniprot id: A0A2I3GW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61853:FASLG
gene id: 61853:FASLG
uniprot id: A0A2I3G609
uniprot id: G1RZ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

61853:LOC100591962
gene id: 61853:LOC100591962
uniprot id: A0A2I3GFS3
uniprot id: G1RIS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

61853:NAA40
gene id: 61853:NAA40
uniprot id: A0A2I3HB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

61853:ENTPD3
gene id: 61853:ENTPD3
uniprot id: G1R107
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61853:CMC4
gene id: 61853:CMC4
uniprot id: A0A2I3H3X4
names: Similarity
messages: Belongs to the CMC4 family.

61853:LOC100580435
gene id: 61853:LOC100580435
uniprot id: G1S6C6
names: Similarity
messages: Belongs to the globin family.

61853:MAP3K13
gene id: 61853:MAP3K13
uniprot id: G1R3U1
names: Function
names: Similarity
messages: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

61853:STN1
gene id: 61853:STN1
uniprot id: G1RZ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

61853:LIPT2
gene id: 61853:LIPT2
uniprot id: G1S568
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

61853:NUDT19
gene id: 61853:NUDT19
uniprot id: G1R7V0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

61853:ND1
gene id: 61853:ND1
uniprot id: E7EAE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

61853:LOC100595338
gene id: 61853:LOC100595338
uniprot id: A0A2I3G0J7
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61853:AGRP
gene id: 61853:AGRP
uniprot id: G1QXQ3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:PALM2AKAP2
gene id: 61853:PALM2AKAP2
uniprot id: A0A2I3GQK4
names: Similarity
messages: Belongs to the paralemmin family.

61853:HSPA8
gene id: 61853:HSPA8
uniprot id: A0A2I3HNE7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61853:AKR1B1
gene id: 61853:AKR1B1
uniprot id: G1RRK6
names: Similarity
messages: Belongs to the aldo/keto reductase family.

61853:RPL8
gene id: 61853:RPL8
uniprot id: G1RJH7
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

61853:EIF4A3
gene id: 61853:EIF4A3
uniprot id: G1S090
names: Similarity
messages: Belongs to the DEAD box helicase family.

61853:ZSCAN9
gene id: 61853:ZSCAN9
uniprot id: G1QWX9
names: Subcellular Location Annotation
messages: Nucleus

61853:MYD88
gene id: 61853:MYD88
uniprot id: A0A2I3HMD5
uniprot id: G1QZU2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.

61853:RDH11
gene id: 61853:RDH11
uniprot id: G1QJA6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61853:LOC100582700
gene id: 61853:LOC100582700
uniprot id: G1SAM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:CBWD1
gene id: 61853:CBWD1
uniprot id: A0A2I3GAQ4
uniprot id: G1RAL8
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

61853:NUF2
gene id: 61853:NUF2
uniprot id: G1RX55
names: Similarity
messages: Belongs to the NUF2 family.

61853:ATP1A2
gene id: 61853:ATP1A2
uniprot id: A0A2I3HW78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:ASPA
gene id: 61853:ASPA
uniprot id: G1S5Z4
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

61853:MCTS1
gene id: 61853:MCTS1
uniprot id: A0A2I3HB06
uniprot id: G1RYD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

61853:PLK4
gene id: 61853:PLK4
uniprot id: G1RTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Cleavage furrow
messages: centriole

61853:TXK
gene id: 61853:TXK
uniprot id: G1S6F7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61853:MRPL44
gene id: 61853:MRPL44
uniprot id: A0A2I3GG57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

61853:LYNX1
gene id: 61853:LYNX1
uniprot id: A0A2I3HI63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:SLC41A3
gene id: 61853:SLC41A3
uniprot id: A0A2I3GBP7
uniprot id: G1QJK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

61853:XPO4
gene id: 61853:XPO4
uniprot id: G1QN10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

61853:UTP3
gene id: 61853:UTP3
uniprot id: G1SAB3
names: Similarity
messages: Belongs to the SAS10 family.

61853:SLC4A8
gene id: 61853:SLC4A8
uniprot id: G1S7T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

61853:ROM1
gene id: 61853:ROM1
uniprot id: G1QV04
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

61853:ASB3
gene id: 61853:ASB3
uniprot id: A0A2I3HLT6
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:ACTL6B
gene id: 61853:ACTL6B
uniprot id: G1RMK5
names: Similarity
messages: Belongs to the actin family.

61853:APOC4
gene id: 61853:APOC4
uniprot id: G1QME5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

61853:ZCCHC8
gene id: 61853:ZCCHC8
uniprot id: G1QMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

61853:LOC100584631
gene id: 61853:LOC100584631
uniprot id: A0A2I3GC38
names: Subcellular Location Annotation
messages: Membrane

61853:ARF6
gene id: 61853:ARF6
uniprot id: A0A2I3GLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

61853:PRKCB
gene id: 61853:PRKCB
uniprot id: A0A2I3HJQ3
uniprot id: G1RMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

61853:SYT14
gene id: 61853:SYT14
uniprot id: A0A2I3FV99
uniprot id: A0A2I3HQW6
names: Similarity
messages: Belongs to the synaptotagmin family.

61853:SAP18
gene id: 61853:SAP18
uniprot id: G1QNB9
names: Similarity
messages: Belongs to the SAP18 family.

61853:LIPG
gene id: 61853:LIPG
uniprot id: G1RLF6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61853:SERPINH1
gene id: 61853:SERPINH1
uniprot id: G1S4S0
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

61853:UPP1
gene id: 61853:UPP1
uniprot id: G1QX82
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

61853:NUP133
gene id: 61853:NUP133
uniprot id: G1RWC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

61853:KPNA4
gene id: 61853:KPNA4
uniprot id: G1QXC4
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61853:TIMM10
gene id: 61853:TIMM10
uniprot id: G1RQK8
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

61853:SPCS2
gene id: 61853:SPCS2
uniprot id: A0A2I3G2F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:FLOT2
gene id: 61853:FLOT2
uniprot id: A0A2I3GZQ1
uniprot id: G1QSA3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane
messages: caveola

61853:FAM171B
gene id: 61853:FAM171B
uniprot id: G1R3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

61853:CPSF7
gene id: 61853:CPSF7
uniprot id: G1QQB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

61853:PRPF18
gene id: 61853:PRPF18
uniprot id: G1RNI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

61853:HOXC9
gene id: 61853:HOXC9
uniprot id: G1S7G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

61853:TMEM186
gene id: 61853:TMEM186
uniprot id: A0A2I3HW99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

61853:CDK15
gene id: 61853:CDK15
uniprot id: A0A2I3GNU6
uniprot id: A0A2I3HSF2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:MT1E
gene id: 61853:MT1E
uniprot id: G1QP40
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61853:ING3
gene id: 61853:ING3
uniprot id: A0A2I3FUM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61853:LOC100580823
gene id: 61853:LOC100580823
uniprot id: G1QJ66
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

61853:CR2
gene id: 61853:CR2
uniprot id: A0A2I3G1L1
uniprot id: A0A2I3HBK1
uniprot id: G1QKA0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100585654
gene id: 61853:LOC100585654
uniprot id: G1S983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:ZBTB8OS
gene id: 61853:ZBTB8OS
uniprot id: A0A2I3H0B6
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

61853:DPF3
gene id: 61853:DPF3
uniprot id: G1QPT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the requiem/DPF family.
messages: Nucleus

61853:NLRP14
gene id: 61853:NLRP14
uniprot id: G1S6S9
names: Similarity
messages: Belongs to the NLRP family.

61853:PSMD2
gene id: 61853:PSMD2
uniprot id: A0A2I3HIP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S2 family.
messages: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

61853:C1RL
gene id: 61853:C1RL
uniprot id: G1QZ62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100585841
gene id: 61853:LOC100585841
uniprot id: G1S9V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PRPF4B
gene id: 61853:PRPF4B
uniprot id: G1RKL9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

61853:HBQ1
gene id: 61853:HBQ1
uniprot id: G1R965
names: Similarity
messages: Belongs to the globin family.

61853:TM4SF1
gene id: 61853:TM4SF1
uniprot id: G1QRX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61853:CPB1
gene id: 61853:CPB1
uniprot id: G1QQ02
names: Similarity
messages: Belongs to the peptidase M14 family.

61853:LOC100605289
gene id: 61853:LOC100605289
uniprot id: G1SBD3
names: Subcellular Location Annotation
messages: Membrane

61853:GPR87
gene id: 61853:GPR87
uniprot id: G1QTF3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:CENPO
gene id: 61853:CENPO
uniprot id: A0A2I3G494
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

61853:NLRP12
gene id: 61853:NLRP12
uniprot id: A0A2I3HZ34
uniprot id: G1R2T8
names: Similarity
messages: Belongs to the NLRP family.

61853:TLX2
gene id: 61853:TLX2
uniprot id: G1QIZ5
names: Subcellular Location Annotation
messages: Nucleus

61853:CDH8
gene id: 61853:CDH8
uniprot id: G1QUR8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61853:RAG2
gene id: 61853:RAG2
uniprot id: G1S8G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

61853:ATP8A1
gene id: 61853:ATP8A1
uniprot id: A0A2I3I0G8
uniprot id: G1S657
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

61853:CD8A
gene id: 61853:CD8A
uniprot id: A0A2I3GKY7
uniprot id: G1QRH2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:FGFR1OP
gene id: 61853:FGFR1OP
uniprot id: A0A2I3HST7
uniprot id: G1RLN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

61853:SLCO1B3
gene id: 61853:SLCO1B3
uniprot id: G1QXP1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:CRYGS
gene id: 61853:CRYGS
uniprot id: G1R449
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61853:GATA4
gene id: 61853:GATA4
uniprot id: A0A2I3GVE3
uniprot id: G1RYG7
names: Subcellular Location Annotation
messages: Nucleus

61853:DLGAP1
gene id: 61853:DLGAP1
uniprot id: A0A2I3GR27
uniprot id: A0A2I3H2M6
uniprot id: G1R5F0
names: Similarity
messages: Belongs to the SAPAP family.

61853:CCNB1
gene id: 61853:CCNB1
uniprot id: G1QVD5
names: Similarity
messages: Belongs to the cyclin family.

61853:COQ10A
gene id: 61853:COQ10A
uniprot id: G1S6X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

61853:KCTD3
gene id: 61853:KCTD3
uniprot id: G1RW06
names: Similarity
messages: Belongs to the KCTD3 family.

61853:CCR6
gene id: 61853:CCR6
uniprot id: A0A2I3GQJ9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:UGGT1
gene id: 61853:UGGT1
uniprot id: G1S1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

61853:SLC25A11
gene id: 61853:SLC25A11
uniprot id: A0A2I3GN19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61853:NINJ1
gene id: 61853:NINJ1
uniprot id: G1S3J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

61853:IFITM5
gene id: 61853:IFITM5
uniprot id: G1R9V0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:TPMT
gene id: 61853:TPMT
uniprot id: A0A2I3HBX2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

61853:IL17RB
gene id: 61853:IL17RB
uniprot id: G1R6J8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:CMTM5
gene id: 61853:CMTM5
uniprot id: G1RYF3
names: Subcellular Location Annotation
messages: Membrane

61853:GLA
gene id: 61853:GLA
uniprot id: A0A2I3HYM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

61853:WIF1
gene id: 61853:WIF1
uniprot id: G1QS54
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:CTPS1
gene id: 61853:CTPS1
uniprot id: G1RNR2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

61853:SPARC
gene id: 61853:SPARC
uniprot id: G1S383
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

61853:AADACL3
gene id: 61853:AADACL3
uniprot id: A0A2I3G1B6
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61853:NT5DC3
gene id: 61853:NT5DC3
uniprot id: G1R3Y8
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

61853:RTCB
gene id: 61853:RTCB
uniprot id: G1QYT2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

61853:PAGE1
gene id: 61853:PAGE1
uniprot id: G1R9I5
names: Similarity
messages: Belongs to the GAGE family.

61853:CFAP97
gene id: 61853:CFAP97
uniprot id: A0A2I3HR42
names: Similarity
messages: Belongs to the CFAP97 family.

61853:NAPG
gene id: 61853:NAPG
uniprot id: A0A2I3GQH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

61853:SNX7
gene id: 61853:SNX7
uniprot id: G1RKY2
names: Similarity
messages: Belongs to the sorting nexin family.

61853:ALDH1L2
gene id: 61853:ALDH1L2
uniprot id: A0A2I3GN32
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

61853:EXOC1
gene id: 61853:EXOC1
uniprot id: A0A2I3GFD9
uniprot id: A0A2I3HMA3
uniprot id: G1RBD9
names: Similarity
messages: Belongs to the SEC3 family.

61853:ACTR6
gene id: 61853:ACTR6
uniprot id: A0A2I3HU17
names: Similarity
messages: Belongs to the actin family. ARP6 subfamily.

61853:RBFOX2
gene id: 61853:RBFOX2
uniprot id: A0A2I3HBJ5
uniprot id: A0A2I3HJ98
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

61853:FECH
gene id: 61853:FECH
uniprot id: G1R9G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

61853:GJA5
gene id: 61853:GJA5
uniprot id: A0A2I3GLU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61853:LOC100587724
gene id: 61853:LOC100587724
uniprot id: A0A2I3HHT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:AVP
gene id: 61853:AVP
uniprot id: G1R7N5
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

61853:PAGE3
gene id: 61853:PAGE3
uniprot id: G1S2T8
names: Similarity
messages: Belongs to the GAGE family.

61853:SLC16A4
gene id: 61853:SLC16A4
uniprot id: A0A2I3HRF7
names: Subcellular Location Annotation
messages: Membrane

61853:DEFA6
gene id: 61853:DEFA6
uniprot id: G1RY39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

61853:ATAT1
gene id: 61853:ATAT1
uniprot id: A0A2I3GXS9
uniprot id: A0A2I3HLC2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation strongly increases tubulin acetylation.
messages: Belongs to the acetyltransferase ATAT1 family.
messages: Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.
messages: Cytoplasm
messages: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
messages: axon
messages: clathrin-coated pit
messages: cytoskeleton
messages: focal adhesion
messages: spindle

61853:TMEM192
gene id: 61853:TMEM192
uniprot id: M3ZB07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

61853:SYPL1
gene id: 61853:SYPL1
uniprot id: A0A2I3GD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61853:LAMTOR5
gene id: 61853:LAMTOR5
uniprot id: G1QTV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

61853:DMRTC2
gene id: 61853:DMRTC2
uniprot id: G1RT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61853:URM1
gene id: 61853:URM1
uniprot id: A0A2I3G169
uniprot id: A0A2I3GQ10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

61853:CNR2
gene id: 61853:CNR2
uniprot id: G1RBV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:PRKAR2A
gene id: 61853:PRKAR2A
uniprot id: A0A2I3GJS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61853:DPPA2
gene id: 61853:DPPA2
uniprot id: G1QV94
names: Subcellular Location Annotation
messages: Nucleus

61853:GPN3
gene id: 61853:GPN3
uniprot id: A0A2I3HNZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

61853:KRT82
gene id: 61853:KRT82
uniprot id: G1S7R5
names: Similarity
messages: Belongs to the intermediate filament family.

61853:PPP1CB
gene id: 61853:PPP1CB
uniprot id: G1RZE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm
messages: nucleolus
messages: nucleoplasm

61853:POLR3C
gene id: 61853:POLR3C
uniprot id: G1R0Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61853:TMEM132D
gene id: 61853:TMEM132D
uniprot id: G1R9V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

61853:LOC100580385
gene id: 61853:LOC100580385
uniprot id: H9H9Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

61853:PPM1L
gene id: 61853:PPM1L
uniprot id: A0A2I3G3V5
names: Similarity
messages: Belongs to the PP2C family.

61853:IFRD1
gene id: 61853:IFRD1
uniprot id: G1RKL6
names: Similarity
messages: Belongs to the IFRD family.

61853:TUBB1
gene id: 61853:TUBB1
uniprot id: G1REK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61853:EEF1AKMT1
gene id: 61853:EEF1AKMT1
uniprot id: G1QMJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
messages: Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.

61853:ALDH4A1
gene id: 61853:ALDH4A1
uniprot id: A0A2I3FUQ8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61853:LOC100587151
gene id: 61853:LOC100587151
uniprot id: G1SBF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:NEIL3
gene id: 61853:NEIL3
uniprot id: G1S4I9
names: Similarity
messages: Belongs to the FPG family.

61853:C8G
gene id: 61853:C8G
uniprot id: G1RBH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

61853:NRXN3
gene id: 61853:NRXN3
uniprot id: A0A2I3G2N0
uniprot id: G1S4G4
uniprot id: G1S4H6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:MRPL12
gene id: 61853:MRPL12
uniprot id: A0A2I3H9N0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

61853:TOR2A
gene id: 61853:TOR2A
uniprot id: G1S6S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

61853:POLR1B
gene id: 61853:POLR1B
uniprot id: A0A2I3GC16
uniprot id: A0A2I3HKQ5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

61853:TMSB15A
gene id: 61853:TMSB15A
uniprot id: G1RTC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61853:LOC100607821
gene id: 61853:LOC100607821
uniprot id: A0A2I3GP74
uniprot id: G1RE81
uniprot id: G1SA16
uniprot id: G1SA17
uniprot id: G1SA18
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

61853:CALCA
gene id: 61853:CALCA
uniprot id: G1S7K5
uniprot id: H9H9X5
names: Similarity
messages: Belongs to the calcitonin family.

61853:TMEM14C
gene id: 61853:TMEM14C
uniprot id: G1QIE2
names: Similarity
messages: Belongs to the TMEM14 family.

61853:AQP10
gene id: 61853:AQP10
uniprot id: G1RKI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61853:HMOX2
gene id: 61853:HMOX2
uniprot id: G1RFL6
names: Similarity
messages: Belongs to the heme oxygenase family.

61853:PROKR2
gene id: 61853:PROKR2
uniprot id: G1R865
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:SIAH1
gene id: 61853:SIAH1
uniprot id: A0A2I3GIT7
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

61853:ANAPC11
gene id: 61853:ANAPC11
uniprot id: G1RH68
names: Similarity
messages: Belongs to the RING-box family.

61853:LOC100597977
gene id: 61853:LOC100597977
uniprot id: A0A2I3GFP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:MRPL3
gene id: 61853:MRPL3
uniprot id: A0A2I3H315
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

61853:DCK
gene id: 61853:DCK
uniprot id: G1R861
names: Similarity
messages: Belongs to the DCK/DGK family.

61853:SERPINB6
gene id: 61853:SERPINB6
uniprot id: A0A2I3HZC5
names: Similarity
messages: Belongs to the serpin family.

61853:INS
gene id: 61853:INS
uniprot id: A0A2I3HNQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

61853:SLC25A3
gene id: 61853:SLC25A3
uniprot id: G1R250
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

61853:GDF10
gene id: 61853:GDF10
uniprot id: G1RZT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

61853:HIGD1B
gene id: 61853:HIGD1B
uniprot id: G1QZE2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

61853:MYO9A
gene id: 61853:MYO9A
uniprot id: G1RU69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cytoplasm
messages: Membrane
messages: Synapse
messages: growth cone

61853:CXCL9
gene id: 61853:CXCL9
uniprot id: G1R9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:TMEM47
gene id: 61853:TMEM47
uniprot id: G1QHP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

61853:ADSL
gene id: 61853:ADSL
uniprot id: A0A2I3HJ95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

61853:FOXI3
gene id: 61853:FOXI3
uniprot id: G1QRU0
names: Subcellular Location Annotation
messages: Nucleus

61853:LOC100602900
gene id: 61853:LOC100602900
uniprot id: A0A2I3H7U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:SRXN1
gene id: 61853:SRXN1
uniprot id: A0A2I3GA43
names: Similarity
messages: Belongs to the sulfiredoxin family.

61853:CSRNP3
gene id: 61853:CSRNP3
uniprot id: G1QSF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

61853:TARS1
gene id: 61853:TARS1
uniprot id: G1RVM5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61853:RDH10
gene id: 61853:RDH10
uniprot id: A0A2I3HQ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61853:SLC26A2
gene id: 61853:SLC26A2
uniprot id: G1RGU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sulfate transporter. May play a role in endochondral bone formation.

61853:AACS
gene id: 61853:AACS
uniprot id: G1QQP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

61853:MEF2C
gene id: 61853:MEF2C
uniprot id: A0A2I3HY69
names: Subcellular Location Annotation
messages: Nucleus

61853:PTP4A2
gene id: 61853:PTP4A2
uniprot id: A0A2I3FQQ1
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61853:ACTC1
gene id: 61853:ACTC1
uniprot id: G1RK14
names: Similarity
messages: Belongs to the actin family.

61853:LOC100600090
gene id: 61853:LOC100600090
uniprot id: G1RGS9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61853:GORASP2
gene id: 61853:GORASP2
uniprot id: A0A2I3HGY7
names: Similarity
messages: Belongs to the GORASP family.

61853:GPR83
gene id: 61853:GPR83
uniprot id: A0A2I3GUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61853:NR2E1
gene id: 61853:NR2E1
uniprot id: G1RTH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61853:ISY1
gene id: 61853:ISY1
uniprot id: A0A2I3GVL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

61853:IARS2
gene id: 61853:IARS2
uniprot id: G1RUL6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61853:GANAB
gene id: 61853:GANAB
uniprot id: A0A2I3FUP5
uniprot id: G1QV88
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

61853:METAP1
gene id: 61853:METAP1
uniprot id: G1RUR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

61853:DNASE1L3
gene id: 61853:DNASE1L3
uniprot id: G1R6T4
names: Similarity
messages: Belongs to the DNase I family.

61853:MOB3C
gene id: 61853:MOB3C
uniprot id: G1S359
names: Similarity
messages: Belongs to the MOB1/phocein family.

61853:CPSF6
gene id: 61853:CPSF6
uniprot id: A0A2I3HRI7
uniprot id: G1QUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Cytoplasm
messages: Nucleus speckle
messages: nucleoplasm

61853:RNMT
gene id: 61853:RNMT
uniprot id: G1RDH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

61853:PIANP
gene id: 61853:PIANP
uniprot id: A0A2I3H1T8
names: Subcellular Location Annotation
messages: Membrane

61853:CBLIF
gene id: 61853:CBLIF
uniprot id: G1RRT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

61853:TMC5
gene id: 61853:TMC5
uniprot id: A0A2I3GBZ8
uniprot id: A0A2I3HDF9
uniprot id: A0A2I3HX68
uniprot id: G1R001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61853:LOC100587339
gene id: 61853:LOC100587339
uniprot id: G1QS81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:ASB4
gene id: 61853:ASB4
uniprot id: G1S134
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61853:TSPYL4
gene id: 61853:TSPYL4
uniprot id: A0A2I3HAB1
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61853:NDUFB3
gene id: 61853:NDUFB3
uniprot id: G1R5J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

61853:ADPRM
gene id: 61853:ADPRM
uniprot id: G1RH33
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

61853:EOMES
gene id: 61853:EOMES
uniprot id: G1QVE0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61853:VPS4A
gene id: 61853:VPS4A
uniprot id: A0A2I3HIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61853:UBE3A
gene id: 61853:UBE3A
uniprot id: G1QLH8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

61853:ST6GALNAC6
gene id: 61853:ST6GALNAC6
uniprot id: A0A2I3HG10
uniprot id: G1S6W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61853:SPRR2G
gene id: 61853:SPRR2G
uniprot id: A0A2I3HIG0
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61853:ADGRD1
gene id: 61853:ADGRD1
uniprot id: A0A2I3HYW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61853:NR3C1
gene id: 61853:NR3C1
uniprot id: M3ZBD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

61853:PSME2
gene id: 61853:PSME2
uniprot id: G1RZ59
names: Similarity
messages: Belongs to the PA28 family.

61853:THBS1
gene id: 61853:THBS1
uniprot id: G1QNM9
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:TBC1D23
gene id: 61853:TBC1D23
uniprot id: G1QQF2
names: Subcellular Location Annotation
messages: trans-Golgi network

61853:RBL1
gene id: 61853:RBL1
uniprot id: G1R2W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

61853:TBL1XR1
gene id: 61853:TBL1XR1
uniprot id: G1R0W6
names: Similarity
messages: Belongs to the WD repeat EBI family.

61853:MSMB
gene id: 61853:MSMB
uniprot id: G1S1P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

61853:WNT8B
gene id: 61853:WNT8B
uniprot id: G1RXH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61853:LPO
gene id: 61853:LPO
uniprot id: A0A2I3G459
uniprot id: A0A2I3H7U3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Secreted

61853:CD46
gene id: 61853:CD46
uniprot id: A0A2I3G5H4
uniprot id: A0A2I3H8B8
uniprot id: A0A2I3HJ87
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

61853:ZNF408
gene id: 61853:ZNF408
uniprot id: G1RVA2
names: Subcellular Location Annotation
messages: Nucleus

61853:ARRB2
gene id: 61853:ARRB2
uniprot id: A0A2I3HNF6
names: Similarity
messages: Belongs to the arrestin family.

61853:TM4SF5
gene id: 61853:TM4SF5
uniprot id: G1S6H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61853:HMMR
gene id: 61853:HMMR
uniprot id: A0A2I3GR02
uniprot id: A0A2I3HW09
uniprot id: G1QXW0
names: Subcellular Location Annotation
messages: spindle

61853:LOC100589494
gene id: 61853:LOC100589494
uniprot id: G1QRP6
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

61853:SNX13
gene id: 61853:SNX13
uniprot id: G1S3P9
names: Similarity
messages: Belongs to the sorting nexin family.

61853:IL17A
gene id: 61853:IL17A
uniprot id: G1QUS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61853:TOX4
gene id: 61853:TOX4
uniprot id: G1RWT6
names: Subcellular Location Annotation
messages: Nucleus

61853:SRPRA
gene id: 61853:SRPRA
uniprot id: A0A2I3GK36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

61853:LHFPL1
gene id: 61853:LHFPL1
uniprot id: G1RX02
names: Subcellular Location Annotation
messages: Membrane

61853:WRN
gene id: 61853:WRN
uniprot id: A0A2I3HQW0
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

61853:FZD10
gene id: 61853:FZD10
uniprot id: G1SAN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Membrane

61853:EEF2K
gene id: 61853:EEF2K
uniprot id: A0A2I3H1F9
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

61853:NSMCE1
gene id: 61853:NSMCE1
uniprot id: G1RLW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

61853:MCOLN2
gene id: 61853:MCOLN2
uniprot id: G1RG31
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61853:PPP1R3C
gene id: 61853:PPP1R3C
uniprot id: G1RPF2
names: Domain
names: Function
names: Subunit
messages: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.
messages: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.
messages: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase.

61853:TCP1
gene id: 61853:TCP1
uniprot id: G1RKC3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

61853:FABP9
gene id: 61853:FABP9
uniprot id: G1QPZ3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:NUDT7
gene id: 61853:NUDT7
uniprot id: A0A2I3HWT9
uniprot id: G1RS58
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

61853:GNAI2
gene id: 61853:GNAI2
uniprot id: A0A2I3HLR3
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61853:MMRN1
gene id: 61853:MMRN1
uniprot id: G1RVZ5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:OAS1
gene id: 61853:OAS1
uniprot id: A0A2I3H3E5
uniprot id: G1QGV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

61853:FGF11
gene id: 61853:FGF11
uniprot id: G1RE41
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61853:LOC100596593
gene id: 61853:LOC100596593
uniprot id: A0A2I3GCA4
names: Similarity
messages: Belongs to the SPAN-X family.

61853:KCNE4
gene id: 61853:KCNE4
uniprot id: A0A2I3G959
names: Similarity
messages: Belongs to the potassium channel KCNE family.

61853:GNAI3
gene id: 61853:GNAI3
uniprot id: A0A2I3HE78
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61853:LOC100595460
gene id: 61853:LOC100595460
uniprot id: G1RKL1
names: Similarity
messages: Belongs to the MHC class I family.

61853:ATP5PO
gene id: 61853:ATP5PO
uniprot id: A0A2I3HI07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

61853:RPL39
gene id: 61853:RPL39
uniprot id: A0A2I3HQ79
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

61853:GTF2E2
gene id: 61853:GTF2E2
uniprot id: G1RMM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

61853:RASGRP4
gene id: 61853:RASGRP4
uniprot id: A0A2I3G2S9
uniprot id: A0A2I3GQ05
uniprot id: G1S4N8
names: Similarity
messages: Belongs to the RASGRP family.

61853:GPR4
gene id: 61853:GPR4
uniprot id: A0A2I3FQU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:GLYCTK
gene id: 61853:GLYCTK
uniprot id: G1R637
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

61853:MUC13
gene id: 61853:MUC13
uniprot id: G1QIT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:FAM83D
gene id: 61853:FAM83D
uniprot id: A0A2I3H9G1
names: Similarity
messages: Belongs to the FAM83 family.

61853:NAV3
gene id: 61853:NAV3
uniprot id: A0A2I3GLD5
names: Similarity
messages: Belongs to the Nav/unc-53 family.

61853:NADK2
gene id: 61853:NADK2
uniprot id: G1S1U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

61853:SYNDIG1L
gene id: 61853:SYNDIG1L
uniprot id: G1S2H5
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61853:MED23
gene id: 61853:MED23
uniprot id: G1RWE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 23 family.
messages: Nucleus

61853:MTNR1A
gene id: 61853:MTNR1A
uniprot id: G1RLF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

61853:SLC39A12
gene id: 61853:SLC39A12
uniprot id: A0A2I3H6G5
uniprot id: G1RQ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

61853:TOP1
gene id: 61853:TOP1
uniprot id: G1R3V8
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

61853:ZC3H15
gene id: 61853:ZC3H15
uniprot id: G1R3T6
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

61853:STX11
gene id: 61853:STX11
uniprot id: G1RYS7
names: Similarity
messages: Belongs to the syntaxin family.

61853:GDF9
gene id: 61853:GDF9
uniprot id: G1RQV5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

61853:PDE7A
gene id: 61853:PDE7A
uniprot id: A0A2I3GCA2
uniprot id: G1QV53
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:SV2A
gene id: 61853:SV2A
uniprot id: G1REY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

61853:ATG4A
gene id: 61853:ATG4A
uniprot id: A0A2I3GSB1
uniprot id: G1RV27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

61853:DPY30
gene id: 61853:DPY30
uniprot id: A0A2I3GIG7
names: Similarity
messages: Belongs to the dpy-30 family.

61853:KIF21A
gene id: 61853:KIF21A
uniprot id: A0A2I3GGY9
uniprot id: A0A2I3HIM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

61853:SYT16
gene id: 61853:SYT16
uniprot id: G1RUV8
names: Similarity
messages: Belongs to the synaptotagmin family.

61853:PHF19
gene id: 61853:PHF19
uniprot id: A0A2I3HDV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

61853:DAPK2
gene id: 61853:DAPK2
uniprot id: A0A2I3FWL6
uniprot id: A0A2I3HB00
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:LOC100598768
gene id: 61853:LOC100598768
uniprot id: G1RYB4
names: Similarity
messages: Belongs to the Bcl-2 family.

61853:ZFPL1
gene id: 61853:ZFPL1
uniprot id: G1R0B3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

61853:GPR39
gene id: 61853:GPR39
uniprot id: G1RA66
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61853:PYY
gene id: 61853:PYY
uniprot id: G1R0R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

61853:NAP1L3
gene id: 61853:NAP1L3
uniprot id: G1QJC9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61853:LOC100601632
gene id: 61853:LOC100601632
uniprot id: G1SC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61853:EPS8L1
gene id: 61853:EPS8L1
uniprot id: G1RIL0
names: Similarity
messages: Belongs to the EPS8 family.

61853:HAAO
gene id: 61853:HAAO
uniprot id: G1S437
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

61853:AMIGO1
gene id: 61853:AMIGO1
uniprot id: G1QRE0
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

61853:CDCA5
gene id: 61853:CDCA5
uniprot id: G1R099
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61853:CALHM6
gene id: 61853:CALHM6
uniprot id: A0A2I3G904
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61853:PTGES
gene id: 61853:PTGES
uniprot id: G1S7D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

61853:POU2F1
gene id: 61853:POU2F1
uniprot id: A0A2I3HNQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

61853:MRPL2
gene id: 61853:MRPL2
uniprot id: G1QWI3
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

61853:CXCL11
gene id: 61853:CXCL11
uniprot id: G1R9B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61853:IL7
gene id: 61853:IL7
uniprot id: A0A2I3G1Y2
uniprot id: A0A2I3GFK4
uniprot id: A0A2I3H3T9
uniprot id: G1QNL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

61853:POPDC3
gene id: 61853:POPDC3
uniprot id: G1RVC5
names: Similarity
messages: Belongs to the popeye family.

61853:GRM3
gene id: 61853:GRM3
uniprot id: G1RXY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
messages: Interacts with TAMALIN.
messages: Membrane

61853:PDE4A
gene id: 61853:PDE4A
uniprot id: G1RNP7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61853:DUOXA2
gene id: 61853:DUOXA2
uniprot id: A0A2I3HZI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DUOXA family.
messages: Membrane

61853:SBK1
gene id: 61853:SBK1
uniprot id: G1RL98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

61853:PNMA2
gene id: 61853:PNMA2
uniprot id: G1SBN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

61853:APC
gene id: 61853:APC
uniprot id: G1RLE9
names: Similarity
messages: Belongs to the adenomatous polyposis coli (APC) family.

61853:LHX2
gene id: 61853:LHX2
uniprot id: A0A2I3G8Y4
names: Subcellular Location Annotation
messages: Nucleus

61853:KCNJ2
gene id: 61853:KCNJ2
uniprot id: A0A2I3GE09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking.
messages: Membrane

61853:CKAP2L
gene id: 61853:CKAP2L
uniprot id: G1QMS1
names: Similarity
messages: Belongs to the CKAP2 family.

61853:SLCO4C1
gene id: 61853:SLCO4C1
uniprot id: G1RJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

61853:PACSIN1
gene id: 61853:PACSIN1
uniprot id: G1RAD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

61853:HDHD2
gene id: 61853:HDHD2
uniprot id: A0A2I3HXK0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

61853:NME6
gene id: 61853:NME6
uniprot id: A0A2I3HWM5
names: Similarity
messages: Belongs to the NDK family.

61853:SLC26A11
gene id: 61853:SLC26A11
uniprot id: G1S0J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane

61853:SERINC2
gene id: 61853:SERINC2
uniprot id: A0A2I3HTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

61853:DOK1
gene id: 61853:DOK1
uniprot id: A0A2I3HKC9
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

61853:PREB
gene id: 61853:PREB
uniprot id: G1QRQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

61853:BMPR1B
gene id: 61853:BMPR1B
uniprot id: G1RVC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61853:OPA3
gene id: 61853:OPA3
uniprot id: G1QP14
uniprot id: M3ZBA5
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

61853:DCP2
gene id: 61853:DCP2
uniprot id: G1RLL2
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

61853:SLC5A2
gene id: 61853:SLC5A2
uniprot id: G1S306
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61853:KCNJ3
gene id: 61853:KCNJ3
uniprot id: A0A2I3HCJ3
uniprot id: G1RKZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.
messages: Membrane
messages: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

61853:ERBIN
gene id: 61853:ERBIN
uniprot id: A0A2I3GR05
uniprot id: A0A2I3HRK2
uniprot id: G1QUH5
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

61853:LOC100602869
gene id: 61853:LOC100602869
uniprot id: G1S7S2
names: Similarity
messages: Belongs to the intermediate filament family.

61853:PSMC6
gene id: 61853:PSMC6
uniprot id: G1RPW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

61853:CNPY2
gene id: 61853:CNPY2
uniprot id: G1S6W6
names: Similarity
messages: Belongs to the canopy family.

61853:MLH1
gene id: 61853:MLH1
uniprot id: G1QYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

61853:SIGMAR1
gene id: 61853:SIGMAR1
uniprot id: G1QY61
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

61853:DNASE2B
gene id: 61853:DNASE2B
uniprot id: G1RFT9
names: Similarity
messages: Belongs to the DNase II family.

61853:ISOC1
gene id: 61853:ISOC1
uniprot id: G1RP92
names: Similarity
messages: Belongs to the isochorismatase family.

61853:SUMF2
gene id: 61853:SUMF2
uniprot id: A0A2I3GYN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

61853:RBP1
gene id: 61853:RBP1
uniprot id: G1QWT2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61853:MRI1
gene id: 61853:MRI1
uniprot id: G1RRR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

61853:RPS14
gene id: 61853:RPS14
uniprot id: A0A2I3I0G1
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

61853:PTGS2
gene id: 61853:PTGS2
uniprot id: G1S8S7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Endoplasmic reticulum membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane
messages: Nucleus inner membrane
messages: Nucleus outer membrane

61853:FAM163A
gene id: 61853:FAM163A
uniprot id: G1S0X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

61853:ZFPM2
gene id: 61853:ZFPM2
uniprot id: G1QV05
names: Subcellular Location Annotation
messages: Nucleus

61853:KCNMB2
gene id: 61853:KCNMB2
uniprot id: G1R0X5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

61853:SF3B5
gene id: 61853:SF3B5
uniprot id: G1SC94
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

61853:BTN1A1
gene id: 61853:BTN1A1
uniprot id: G1QT32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

61853:NRP2
gene id: 61853:NRP2
uniprot id: A0A2I3HU08
uniprot id: G1R609
names: Caution
names: Similarity
messages: Belongs to the neuropilin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LYRM9
gene id: 61853:LYRM9
uniprot id: G1QMF4
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

61853:LOC100599631
gene id: 61853:LOC100599631
uniprot id: A0A2I3GYJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

61853:DPCD
gene id: 61853:DPCD
uniprot id: G1RXX7
names: Similarity
messages: Belongs to the DPCD family.

61853:CDC42BPA
gene id: 61853:CDC42BPA
uniprot id: A0A2I3GH26
uniprot id: A0A2I3H8W7
uniprot id: G1RV13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

61853:PFDN2
gene id: 61853:PFDN2
uniprot id: G1RUR1
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

61853:LOC100594586
gene id: 61853:LOC100594586
uniprot id: G1S9R7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61853:TRH
gene id: 61853:TRH
uniprot id: G1QZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

61853:INPP1
gene id: 61853:INPP1
uniprot id: G1R4H8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61853:TAS2R39
gene id: 61853:TAS2R39
uniprot id: G1S9X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61853:GORAB
gene id: 61853:GORAB
uniprot id: G1RYP2
names: Similarity
messages: Belongs to the GORAB family.

61853:C8A
gene id: 61853:C8A
uniprot id: G1RXC0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

61853:TREM1
gene id: 61853:TREM1
uniprot id: A0A2I3HAV2
uniprot id: G1QYL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61853:TMEM38A
gene id: 61853:TMEM38A
uniprot id: G1R0N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

61853:SLC22A12
gene id: 61853:SLC22A12
uniprot id: A0A2I3GN75
names: Subcellular Location Annotation
messages: Membrane

61853:DIPK2B
gene id: 61853:DIPK2B
uniprot id: A0A2I3FYG9
uniprot id: A0A2I3GC66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

61853:KATNAL1
gene id: 61853:KATNAL1
uniprot id: G1QIT4
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Midbody
messages: Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.
messages: Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

61853:GPAT4
gene id: 61853:GPAT4
uniprot id: A0A2I3GTI6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

61853:MAP2K6
gene id: 61853:MAP2K6
uniprot id: G1QQD5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61853:FOXO3
gene id: 61853:FOXO3
uniprot id: G1RPE6
names: Subcellular Location Annotation
messages: Nucleus

61853:IFI27L2
gene id: 61853:IFI27L2
uniprot id: G1S611
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

61853:THRSP
gene id: 61853:THRSP
uniprot id: A0A2I3HQS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

61853:PRAMEF14
gene id: 61853:PRAMEF14
uniprot id: G1RFN0
names: Similarity
messages: Belongs to the PRAME family.

61853:GSKIP
gene id: 61853:GSKIP
uniprot id: A0A2I3GZL3
names: Similarity
messages: Belongs to the GSKIP family.

61853:MOXD1
gene id: 61853:MOXD1
uniprot id: G1RWT1
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

61853:PIK3IP1
gene id: 61853:PIK3IP1
uniprot id: A0A2I3GXK5
uniprot id: G1QWH9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:HHIP
gene id: 61853:HHIP
uniprot id: G1R071
names: Caution
names: Similarity
messages: Belongs to the HHIP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:LOC100600217
gene id: 61853:LOC100600217
uniprot id: G1S1H8
names: Caution
names: Similarity
messages: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61853:APRT
gene id: 61853:APRT
uniprot id: G1S0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

61853:EIF1B
gene id: 61853:EIF1B
uniprot id: G1R0Y9
names: Similarity
messages: Belongs to the SUI1 family.

61853:NPY
gene id: 61853:NPY
uniprot id: G1RXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

61853:TCTEX1D1
gene id: 61853:TCTEX1D1
uniprot id: G1RZ44
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61853:EXTL2
gene id: 61853:EXTL2
uniprot id: G1RML5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:ACADM
gene id: 61853:ACADM
uniprot id: A0A2I3HGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

61853:HTR4
gene id: 61853:HTR4
uniprot id: A0A2I3GKC8
uniprot id: A0A2I3GM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Endosome
messages: Membrane
messages: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

61853:LOC100581228
gene id: 61853:LOC100581228
uniprot id: G1RGZ8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61853:MGST2
gene id: 61853:MGST2
uniprot id: A0A2I3H5N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61853:LOC100580376
gene id: 61853:LOC100580376
uniprot id: A0A2I3HF62
uniprot id: A0A2I3HJ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61853:TGS1
gene id: 61853:TGS1
uniprot id: G1QK83
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

61853:PTPRN2
gene id: 61853:PTPRN2
uniprot id: A0A2I3HF68
uniprot id: A0A2I3HH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

61853:ADAMTS3
gene id: 61853:ADAMTS3
uniprot id: G1R882
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61853:OSBPL11
gene id: 61853:OSBPL11
uniprot id: G1QJD0
names: Similarity
messages: Belongs to the OSBP family.

61853:MRPL22
gene id: 61853:MRPL22
uniprot id: A0A2I3GUV3
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61853:PLA2G3
gene id: 61853:PLA2G3
uniprot id: G1QW45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

61853:PUS10
gene id: 61853:PUS10
uniprot id: G1REG8
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

61853:CIAPIN1
gene id: 61853:CIAPIN1
uniprot id: G1QRU1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

61853:PLN
gene id: 61853:PLN
uniprot id: A0A2I3GAU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

61853:RAB38
gene id: 61853:RAB38
uniprot id: G1S235
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

61853:ZDHHC4
gene id: 61853:ZDHHC4
uniprot id: G1S0D5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61853:PPP1R12A
gene id: 61853:PPP1R12A
uniprot id: A0A2I3GQA8
uniprot id: A0A2I3HX50
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

61853:RAB39A
gene id: 61853:RAB39A
uniprot id: A0A2I3GE23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

61853:PPP2CB
gene id: 61853:PPP2CB
uniprot id: G1RMV5
names: Similarity
messages: Belongs to the PPP phosphatase family.

61853:TMEM50A
gene id: 61853:TMEM50A
uniprot id: G1RCU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

61853:PDP1
gene id: 61853:PDP1
uniprot id: G1QRM9
names: Similarity
messages: Belongs to the PP2C family.

61853:TSPAN33
gene id: 61853:TSPAN33
uniprot id: G1RPU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61853:TNF
gene id: 61853:TNF
uniprot id: A0A2I3HVV8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.

61853:HSPD1
gene id: 61853:HSPD1
uniprot id: G1R5A6
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

61853:VPS36
gene id: 61853:VPS36
uniprot id: A0A2I3HF48
uniprot id: G1S0V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

61853:SIAH3
gene id: 61853:SIAH3
uniprot id: G1QPZ2
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.