6183:Smp 092810.1
gene id: 6183:Smp_092810.1
uniprot id: G4VEZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

6183:Smp 055920
gene id: 6183:Smp_055920
uniprot id: G4VB87
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 044160
gene id: 6183:Smp_044160
uniprot id: G4VEJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 053560
gene id: 6183:Smp_053560
uniprot id: G4VJ06
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 048230
gene id: 6183:Smp_048230
uniprot id: G4V8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

6183:Smp 003140.1
gene id: 6183:Smp_003140.1
uniprot id: G4V6X9
names: Similarity
messages: Belongs to the sorting nexin family.

6183:Smp 002930
gene id: 6183:Smp_002930
uniprot id: G4VFE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 084620
gene id: 6183:Smp_084620
uniprot id: G4V6D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus

6183:Smp 166280
gene id: 6183:Smp_166280
uniprot id: G4VD11
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

6183:Smp 021040
gene id: 6183:Smp_021040
uniprot id: G4VDL2
names: Similarity
messages: Belongs to the FAM32 family.

6183:Smp 030920.1
gene id: 6183:Smp_030920.1
uniprot id: G4VLT9
uniprot id: G4VLU0
names: Similarity
messages: Belongs to the Tom22 family.

6183:Smp 210260
gene id: 6183:Smp_210260
uniprot id: G4VHA2
names: Similarity
messages: Belongs to the DEAD box helicase family.

6183:Smp 038510.1
gene id: 6183:Smp_038510.1
uniprot id: G4VTG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

6183:Smp 077860
gene id: 6183:Smp_077860
uniprot id: G4VL77
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

6183:Smp 115450
gene id: 6183:Smp_115450
uniprot id: G4VND4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 055200
gene id: 6183:Smp_055200
uniprot id: G4VH66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 028690
gene id: 6183:Smp_028690
uniprot id: Q8MZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

6183:Smp 089000.1
gene id: 6183:Smp_089000.1
uniprot id: G4VHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

6183:Smp 021280
gene id: 6183:Smp_021280
uniprot id: G4V8I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

6183:Smp 169340
gene id: 6183:Smp_169340
uniprot id: G4VKL7
names: Similarity
messages: Belongs to the MIX23 family.

6183:Smp 096910
gene id: 6183:Smp_096910
uniprot id: G4VBL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 042590.1
gene id: 6183:Smp_042590.1
uniprot id: G4VRD9
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

6183:Smp 146210
gene id: 6183:Smp_146210
uniprot id: G4VQR7
names: Similarity
messages: Belongs to the NDK family.

6183:Smp 050880
gene id: 6183:Smp_050880
uniprot id: G4VMI8
names: Similarity
messages: Belongs to the UPF0587 family.

6183:Smp 049550
gene id: 6183:Smp_049550
uniprot id: G4V910
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

6183:Smp 070710
gene id: 6183:Smp_070710
uniprot id: G4VEL6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

6183:Smp 009320.1
gene id: 6183:Smp_009320.1
uniprot id: G4VL25
names: Similarity
messages: Belongs to the SKP1 family.

6183:Smp 091480
gene id: 6183:Smp_091480
uniprot id: G4V9L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

6183:Smp 085010
gene id: 6183:Smp_085010
uniprot id: G4V5D3
names: Similarity
messages: Belongs to the peptidase C1 family.

6183:KEF69 p05
gene id: 6183:KEF69_p05
uniprot id: Q9B8X3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 086480
gene id: 6183:Smp_086480
uniprot id: P32070
names: Developmental Stage
messages: Occurs in similar relative abundances in infected hepatopancreas, schistosomula and adults.

6183:Smp 136400
gene id: 6183:Smp_136400
uniprot id: G4VEX7
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

6183:Smp 041980
gene id: 6183:Smp_041980
uniprot id: G4VJS1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

6183:Smp 005020
gene id: 6183:Smp_005020
uniprot id: G4VQX3
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

6183:Smp 210280
gene id: 6183:Smp_210280
uniprot id: G4VJK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

6183:Smp 046090.1
gene id: 6183:Smp_046090.1
uniprot id: G4VPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

6183:Smp 042790
gene id: 6183:Smp_042790
uniprot id: G4VIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

6183:Smp 088390
gene id: 6183:Smp_088390
uniprot id: G4VSP2
names: Similarity
messages: Belongs to the PITHD1 family.

6183:Smp 042020.1
gene id: 6183:Smp_042020.1
uniprot id: Q7YTA4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

6183:Smp 023270.1
gene id: 6183:Smp_023270.1
uniprot id: G4VCA6
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 042210
gene id: 6183:Smp_042210
uniprot id: G4VJU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

6183:Smp 102510
gene id: 6183:Smp_102510
uniprot id: G4VJX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

6183:Smp 040790
gene id: 6183:Smp_040790
uniprot id: G4VFQ0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6183:Smp 028990.1
gene id: 6183:Smp_028990.1
uniprot id: G4VGS4
names: Similarity
messages: Belongs to the PPP phosphatase family.

6183:Smp 079970
gene id: 6183:Smp_079970
uniprot id: G4VTA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6183:Smp 200410
gene id: 6183:Smp_200410
uniprot id: G4V8Q8
names: Similarity
messages: Belongs to the thymidylate synthase family.

6183:Smp 012530.1
gene id: 6183:Smp_012530.1
uniprot id: Q15ER1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.
messages: Nucleus

6183:Smp 101970
gene id: 6183:Smp_101970
uniprot id: G4VTB5
names: Similarity
messages: Belongs to the cornifelin family.

6183:Smp 045760
gene id: 6183:Smp_045760
uniprot id: G4VPP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

6183:Smp 131450
gene id: 6183:Smp_131450
uniprot id: G4VTK8
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

6183:Smp 134230
gene id: 6183:Smp_134230
uniprot id: G4VP93
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

6183:Smp 035800
gene id: 6183:Smp_035800
uniprot id: O44125
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

6183:Smp 081250
gene id: 6183:Smp_081250
uniprot id: G4V8N9
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 155740
gene id: 6183:Smp_155740
uniprot id: G4VJ99
names: Similarity
messages: Belongs to the heat shock protein 90 family.

6183:Smp 043670.1
gene id: 6183:Smp_043670.1
uniprot id: G4VKA6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 036220
gene id: 6183:Smp_036220
uniprot id: G4V6E9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 082420
gene id: 6183:Smp_082420
uniprot id: G4VGH9
names: Caution
names: Similarity
names: Subunit
messages: Although this protein has high similarity to uridine phosphorylases, it has no detectable catalytic activity. It contains substitutions at Gly-126 and Gln-201, two conserved sites which are known to be important for uridine binding.
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Homodimer.

6183:Smp 201060
gene id: 6183:Smp_201060
uniprot id: Q94748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a non-catalytic accessory component of a dynein complex.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6183:Smp 019990
gene id: 6183:Smp_019990
uniprot id: G4V8G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Golgi apparatus
messages: clathrin-coated pit

6183:Smp 072350
gene id: 6183:Smp_072350
uniprot id: G4V9B4
names: Similarity
messages: Belongs to the SMEK family.

6183:Smp 078240
gene id: 6183:Smp_078240
uniprot id: G4VLY9
names: Subcellular Location Annotation
messages: nucleoplasm

6183:Smp 100080
gene id: 6183:Smp_100080
uniprot id: G4VG77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6183:Smp 040710
gene id: 6183:Smp_040710
uniprot id: G4VFR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

6183:Smp 126140
gene id: 6183:Smp_126140
uniprot id: C4PYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

6183:Smp 012460
gene id: 6183:Smp_012460
uniprot id: G4V968
names: Similarity
messages: Belongs to the asteroid family.

6183:Smp 026440
gene id: 6183:Smp_026440
uniprot id: G4VT64
names: Similarity
messages: Belongs to the dpy-30 family.

6183:KEF69 p02
gene id: 6183:KEF69_p02
uniprot id: Q9MD44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

6183:Smp 053030
gene id: 6183:Smp_053030
uniprot id: G4VK07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

6183:Smp 004080
gene id: 6183:Smp_004080
uniprot id: G4V6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 008320
gene id: 6183:Smp_008320
uniprot id: G4V7H0
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

6183:Smp 175210
gene id: 6183:Smp_175210
uniprot id: G4VJD9
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

6183:Smp 125780
gene id: 6183:Smp_125780
uniprot id: G4V9W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 062420.1
gene id: 6183:Smp_062420.1
uniprot id: G4VJJ1
names: Similarity
messages: Belongs to the FAM10 family.

6183:Smp 028100.1
gene id: 6183:Smp_028100.1
uniprot id: G4V624
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 143670
gene id: 6183:Smp_143670
uniprot id: G4VKF6
names: Similarity
messages: Belongs to the RRN3 family.

6183:Smp 014800.1
gene id: 6183:Smp_014800.1
uniprot id: G4VBX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

6183:Smp 100140
gene id: 6183:Smp_100140
uniprot id: G4VG84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRTCAP2 family.
messages: Membrane

6183:Smp 102280
gene id: 6183:Smp_102280
uniprot id: G4VDE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

6183:Smp 207000
gene id: 6183:Smp_207000
uniprot id: C4PYP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

6183:Smp 082710.1
gene id: 6183:Smp_082710.1
uniprot id: G4VC87
names: Similarity
messages: Belongs to the glycosyltransferase 28 family.

6183:Smp 094420
gene id: 6183:Smp_094420
uniprot id: G4VC25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

6183:Smp 161960
gene id: 6183:Smp_161960
uniprot id: G4V783
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Nucleus

6183:Smp 067520
gene id: 6183:Smp_067520
uniprot id: G4VQC3
names: Similarity
messages: Belongs to the bZIP family. Jun subfamily.

6183:Smp 017830.1
gene id: 6183:Smp_017830.1
uniprot id: G4VNQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 045560
gene id: 6183:Smp_045560
uniprot id: G4VI62
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6183:Smp 194380
gene id: 6183:Smp_194380
uniprot id: G4VAU1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 010940.1
gene id: 6183:Smp_010940.1
uniprot id: G4VMR9
names: Similarity
messages: Belongs to the ANP32 family.

6183:Smp 129500
gene id: 6183:Smp_129500
uniprot id: G4VH38
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

6183:Smp 119980
gene id: 6183:Smp_119980
uniprot id: G4VMU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 072340
gene id: 6183:Smp_072340
uniprot id: G4V9B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

6183:Smp 003770
gene id: 6183:Smp_003770
uniprot id: G4V6K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

6183:Smp 094950
gene id: 6183:Smp_094950
uniprot id: G4VRY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

6183:Smp 024360.1
gene id: 6183:Smp_024360.1
uniprot id: G4VQ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 074510
gene id: 6183:Smp_074510
uniprot id: G4VRC1
names: Subunit
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

6183:Smp 032760
gene id: 6183:Smp_032760
uniprot id: G4VDH7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

6183:Smp 160870
gene id: 6183:Smp_160870
uniprot id: G4VFW1
names: Similarity
messages: Belongs to the AAA ATPase family.

6183:Smp 052350
gene id: 6183:Smp_052350
uniprot id: G4VF10
names: Similarity
messages: Belongs to the peptidase C64 family.

6183:KEF69 p03
gene id: 6183:KEF69_p03
uniprot id: Q9MD45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

6183:Smp 018030
gene id: 6183:Smp_018030
uniprot id: G4VNZ6
names: Similarity
messages: Belongs to the VPS72/YL1 family.

6183:Smp 094020
gene id: 6183:Smp_094020
uniprot id: G4V5G3
names: Similarity
messages: Belongs to the DEAD box helicase family.

6183:Smp 018010
gene id: 6183:Smp_018010
uniprot id: G4VNZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

6183:Smp 053900
gene id: 6183:Smp_053900
uniprot id: G4VHP9
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

6183:Smp 127660
gene id: 6183:Smp_127660
uniprot id: G4VML7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS8 family.
messages: Lysosome membrane
messages: Membrane

6183:Smp 002550.1
gene id: 6183:Smp_002550.1
uniprot id: G4VF55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

6183:Smp 030910
gene id: 6183:Smp_030910
uniprot id: G4VLT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6183:Smp 105330
gene id: 6183:Smp_105330
uniprot id: G4V5D9
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

6183:Smp 064050.1
gene id: 6183:Smp_064050.1
uniprot id: G4VIM8
names: Similarity
messages: Belongs to the RuvB family.

6183:Smp 031730
gene id: 6183:Smp_031730
uniprot id: G4VN62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 064040.1
gene id: 6183:Smp_064040.1
uniprot id: G4VIN1
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 068100
gene id: 6183:Smp_068100
uniprot id: G4V6Q1
names: Similarity
messages: Belongs to the MFAP1 family.

6183:Smp 056440
gene id: 6183:Smp_056440
uniprot id: G4VSQ5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

6183:Smp 092770
gene id: 6183:Smp_092770
uniprot id: G4V6J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

6183:Smp 002920.1
gene id: 6183:Smp_002920.1
uniprot id: G4VLI4
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 064640
gene id: 6183:Smp_064640
uniprot id: G4VNR3
names: Similarity
messages: Belongs to the RRM TRSPAP family.

6183:Smp 045250
gene id: 6183:Smp_045250
uniprot id: G4VBS1
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 004940
gene id: 6183:Smp_004940
uniprot id: G4V5M1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

6183:Smp 203030
gene id: 6183:Smp_203030
uniprot id: G4VME9
names: Subcellular Location Annotation
messages: Secreted

6183:Smp 021160.1
gene id: 6183:Smp_021160.1
uniprot id: G4VDK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

6183:Smp 128690
gene id: 6183:Smp_128690
uniprot id: G4VS85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

6183:Smp 003710
gene id: 6183:Smp_003710
uniprot id: G4VJX4
names: Subcellular Location Annotation
messages: cytoskeleton

6183:Smp 026160.1
gene id: 6183:Smp_026160.1
uniprot id: G4VKQ6
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 134460
gene id: 6183:Smp_134460
uniprot id: G4VI72
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6183:Smp 005880
gene id: 6183:Smp_005880
uniprot id: G4V721
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

6183:Smp 099850.3
gene id: 6183:Smp_099850.3
uniprot id: G4VAD4
names: Similarity
messages: Belongs to the NRAMP family.

6183:Smp 030290
gene id: 6183:Smp_030290
uniprot id: G4VFN5
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

6183:Smp 144570
gene id: 6183:Smp_144570
uniprot id: G4V7S8
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

6183:Smp 013520
gene id: 6183:Smp_013520
uniprot id: G4VH39
names: Similarity
messages: Belongs to the NCBP3 family.

6183:Smp 064500
gene id: 6183:Smp_064500
uniprot id: G4VKB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

6183:Smp 043030
gene id: 6183:Smp_043030
uniprot id: Q26609
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hexokinase family.
messages: Catalyzes the phosphorylation of various hexoses to hexose 6-phosphate.
messages: Monomer.

6183:Smp 047450
gene id: 6183:Smp_047450
uniprot id: G4VBI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

6183:Smp 102390
gene id: 6183:Smp_102390
uniprot id: G4VBF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0602 family.
messages: centrosome

6183:Smp 047620
gene id: 6183:Smp_047620
uniprot id: G4VBG9
names: Similarity
messages: Belongs to the cyclin family.

6183:Smp 056970.1
gene id: 6183:Smp_056970.1
uniprot id: G4V5I4
uniprot id: P20287
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.
messages: This antigen is associated with human resistance to schistosomiasis.

6183:Smp 035200.1
gene id: 6183:Smp_035200.1
uniprot id: G4V805
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 062900
gene id: 6183:Smp_062900
uniprot id: G4VHU6
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

6183:Smp 001530
gene id: 6183:Smp_001530
uniprot id: G4VCF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

6183:Smp 163170
gene id: 6183:Smp_163170
uniprot id: G4VSU9
names: Similarity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.

6183:Smp 095480
gene id: 6183:Smp_095480
uniprot id: G4V849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6183:Smp 040510
gene id: 6183:Smp_040510
uniprot id: G4VB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

6183:Smp 028140
gene id: 6183:Smp_028140
uniprot id: G4V620
names: Similarity
messages: Belongs to the FCHO family.

6183:Smp 053700
gene id: 6183:Smp_053700
uniprot id: G4VIZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 001500
gene id: 6183:Smp_001500
uniprot id: G4VCF5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

6183:Smp 080150
gene id: 6183:Smp_080150
uniprot id: G4VJM1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6183:Smp 090120.1
gene id: 6183:Smp_090120.1
uniprot id: Q26595
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6183:Smp 161820
gene id: 6183:Smp_161820
uniprot id: G4VA83
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

6183:Smp 000830
gene id: 6183:Smp_000830
uniprot id: G4V658
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 135570
gene id: 6183:Smp_135570
uniprot id: G4VIR8
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family. ARP6 subfamily.

6183:Smp 126020
gene id: 6183:Smp_126020
uniprot id: G4VB23
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Homodimer.

6183:Smp 055960
gene id: 6183:Smp_055960
uniprot id: G4VB90
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 007890.1
gene id: 6183:Smp_007890.1
uniprot id: G4V5P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

6183:Smp 074260
gene id: 6183:Smp_074260
uniprot id: G4VLB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

6183:Smp 025340
gene id: 6183:Smp_025340
uniprot id: G4VPE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 052330
gene id: 6183:Smp_052330
uniprot id: G4VF13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

6183:Smp 091360
gene id: 6183:Smp_091360
uniprot id: G4V9D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pym family.
messages: Cytoplasm

6183:Smp 057320
gene id: 6183:Smp_057320
uniprot id: G4VMW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

6183:Smp 159520
gene id: 6183:Smp_159520
uniprot id: G4VQA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 129420
gene id: 6183:Smp_129420
uniprot id: G4VH52
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

6183:Smp 000810.1
gene id: 6183:Smp_000810.1
uniprot id: G4V664
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

6183:Smp 170340
gene id: 6183:Smp_170340
uniprot id: G4V8A8
names: Subcellular Location Annotation
messages: Membrane
messages: basement membrane

6183:Smp 010800
gene id: 6183:Smp_010800
uniprot id: G4VMQ5
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

6183:Smp 038300
gene id: 6183:Smp_038300
uniprot id: G4VNU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
messages: nucleoplasm

6183:Smp 149350
gene id: 6183:Smp_149350
uniprot id: G4VMI6
names: Similarity
messages: Belongs to the Integrator subunit 12 family.

6183:Smp 027480
gene id: 6183:Smp_027480
uniprot id: G4VIB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion inner membrane

6183:Smp 148160
gene id: 6183:Smp_148160
uniprot id: G4VSB1
names: Similarity
messages: Belongs to the SPATA6 family.

6183:Smp 060760
gene id: 6183:Smp_060760
uniprot id: G4V9N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 076650.1
gene id: 6183:Smp_076650.1
uniprot id: G4VF36
uniprot id: G4VF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

6183:Smp 143490
gene id: 6183:Smp_143490
uniprot id: G4VDE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

6183:Smp 017230
gene id: 6183:Smp_017230
uniprot id: G4VE80
names: Similarity
messages: Belongs to the NAPRTase family.

6183:Smp 046600
gene id: 6183:Smp_046600
uniprot id: P53470
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: cytoskeleton

6183:Smp 075220.1
gene id: 6183:Smp_075220.1
uniprot id: G4VS61
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

6183:Smp 052500
gene id: 6183:Smp_052500
uniprot id: G4VHN9
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 091460
gene id: 6183:Smp_091460
uniprot id: G4V9E4
names: Similarity
messages: Belongs to the glutamine synthetase family.

6183:Smp 055400
gene id: 6183:Smp_055400
uniprot id: G4V5V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCB family.
messages: Cytoplasm

6183:Smp 034490
gene id: 6183:Smp_034490
uniprot id: G4V926
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 023010
gene id: 6183:Smp_023010
uniprot id: Q26549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mitochondrion

6183:Smp 152790
gene id: 6183:Smp_152790
uniprot id: G4V5J2
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

6183:Smp 071830
gene id: 6183:Smp_071830
uniprot id: C4QGM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity).
messages: TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma.

6183:Smp 007900.1
gene id: 6183:Smp_007900.1
uniprot id: G4V5P5
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

6183:Smp 011560
gene id: 6183:Smp_011560
uniprot id: G4VS95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

6183:Smp 173480
gene id: 6183:Smp_173480
uniprot id: G4V9Q9
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

6183:Smp 077230
gene id: 6183:Smp_077230
uniprot id: G4VTW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR1 family.
messages: Golgi apparatus membrane
messages: Membrane

6183:Smp 143780
gene id: 6183:Smp_143780
uniprot id: G4VSR3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

6183:Smp 071880.1
gene id: 6183:Smp_071880.1
uniprot id: G4VCX9
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 046800.1
gene id: 6183:Smp_046800.1
uniprot id: G4VCN1
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

6183:Smp 100110
gene id: 6183:Smp_100110
uniprot id: G4VG80
names: Similarity
messages: Belongs to the DPH3 family.

6183:Smp 060820
gene id: 6183:Smp_060820
uniprot id: G4VBN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

6183:Smp 022990
gene id: 6183:Smp_022990
uniprot id: G4VN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

6183:Smp 063420
gene id: 6183:Smp_063420
uniprot id: G4VF75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

6183:Smp 044020
gene id: 6183:Smp_044020
uniprot id: G4VD35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 011720
gene id: 6183:Smp_011720
uniprot id: G4VSZ9
names: Similarity
messages: Belongs to the PHF5 family.

6183:Smp 013690
gene id: 6183:Smp_013690
uniprot id: G4V6A5
names: Similarity
messages: Belongs to the BROX family.

6183:Smp 082430
gene id: 6183:Smp_082430
uniprot id: G4VGI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:26898674). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable).
messages: Homodimer.

6183:Smp 066990
gene id: 6183:Smp_066990
uniprot id: Q15EU0
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

6183:Smp 208010
gene id: 6183:Smp_208010
uniprot id: G4VDB2
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

6183:Smp 147940.1
gene id: 6183:Smp_147940.1
uniprot id: G4V8V6
names: Similarity
messages: Belongs to the lipin family.

6183:Smp 007660
gene id: 6183:Smp_007660
uniprot id: G4VPZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

6183:Smp 009030
gene id: 6183:Smp_009030
uniprot id: G4VIG3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

6183:Smp 082750
gene id: 6183:Smp_082750
uniprot id: G4VC84
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 049140
gene id: 6183:Smp_049140
uniprot id: G4VC14
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

6183:Smp 095010
gene id: 6183:Smp_095010
uniprot id: G4VRY8
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 034980.1
gene id: 6183:Smp_034980.1
uniprot id: G4V831
uniprot id: G4V832
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 007170
gene id: 6183:Smp_007170
uniprot id: G4VB16
names: Similarity
messages: Belongs to the Mo25 family.

6183:Smp 023150
gene id: 6183:Smp_023150
uniprot id: G4VCC1
names: Similarity
messages: Belongs to the PPP phosphatase family.

6183:Smp 070190
gene id: 6183:Smp_070190
uniprot id: G4VJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: centrosome

6183:Smp 074470
gene id: 6183:Smp_074470
uniprot id: G4VRC6
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

6183:Smp 092490.1
gene id: 6183:Smp_092490.1
uniprot id: G4V5Q1
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

6183:Smp 180140
gene id: 6183:Smp_180140
uniprot id: G4V6S5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6183:Smp 126920
gene id: 6183:Smp_126920
uniprot id: G4VIF5
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 034850
gene id: 6183:Smp_034850
uniprot id: G4V846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

6183:Smp 055340.1
gene id: 6183:Smp_055340.1
uniprot id: G4V5N2
names: Similarity
messages: Belongs to the lin-9 family.

6183:Smp 042560
gene id: 6183:Smp_042560
uniprot id: G4VRE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

6183:Smp 044850
gene id: 6183:Smp_044850
uniprot id: G4VBK5
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

6183:Smp 029100.1
gene id: 6183:Smp_029100.1
uniprot id: G4VGT9
names: Similarity
messages: Belongs to the TRM112 family.

6183:Smp 037460.1
gene id: 6183:Smp_037460.1
uniprot id: G4VE54
names: Similarity
messages: Belongs to the SAS10 family.

6183:Smp 058150.1
gene id: 6183:Smp_058150.1
uniprot id: G4VK46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

6183:Smp 048830
gene id: 6183:Smp_048830
uniprot id: G4VBY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

6183:Smp 044550.1
gene id: 6183:Smp_044550.1
uniprot id: G4VQS9
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 022400
gene id: 6183:Smp_022400
uniprot id: G4VPH5
names: Similarity
messages: Belongs to the GPI family.

6183:Smp 044580
gene id: 6183:Smp_044580
uniprot id: G4VQR9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

6183:Smp 042780
gene id: 6183:Smp_042780
uniprot id: G4VIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 057060
gene id: 6183:Smp_057060
uniprot id: G4V5J1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

6183:Smp 024590
gene id: 6183:Smp_024590
uniprot id: G4VIQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

6183:Smp 002600.1
gene id: 6183:Smp_002600.1
uniprot id: G4VF49
names: Similarity
messages: Belongs to the peptidase S28 family.

6183:Smp 068840
gene id: 6183:Smp_068840
uniprot id: G4VQ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

6183:Smp 042050
gene id: 6183:Smp_042050
uniprot id: G4VJS6
names: Similarity
messages: Belongs to the CWF19 family.

6183:Smp 042990.1
gene id: 6183:Smp_042990.1
uniprot id: G4VIV5
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

6183:Smp 034120
gene id: 6183:Smp_034120
uniprot id: G4V9U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: synaptosome

6183:Smp 097240.1
gene id: 6183:Smp_097240.1
uniprot id: G4V8U3
names: Similarity
messages: Belongs to the MEMO1 family.

6183:Smp 087920
gene id: 6183:Smp_087920
uniprot id: G4VLR7
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.

6183:Smp 181290
gene id: 6183:Smp_181290
uniprot id: G4VER2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

6183:Smp 168520
gene id: 6183:Smp_168520
uniprot id: G4VI74
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

6183:Smp 084830
gene id: 6183:Smp_084830
uniprot id: G4VFD1
names: Function
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

6183:Smp 068250
gene id: 6183:Smp_068250
uniprot id: G4VTC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

6183:Smp 093630.1
gene id: 6183:Smp_093630.1
uniprot id: G4V9Q5
uniprot id: G4V9Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 014280
gene id: 6183:Smp_014280
uniprot id: G4V8T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

6183:Smp 045610
gene id: 6183:Smp_045610
uniprot id: G4VK76
names: Similarity
messages: Belongs to the Rho GDI family.

6183:Smp 170290
gene id: 6183:Smp_170290
uniprot id: G4V8A2
names: Similarity
messages: Belongs to the MAGUK family.

6183:Smp 106060
gene id: 6183:Smp_106060
uniprot id: G4VEN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 052750
gene id: 6183:Smp_052750
uniprot id: G4VM35
names: Similarity
messages: Belongs to the fl(2)d family.

6183:Smp 021300
gene id: 6183:Smp_021300
uniprot id: G4V8H8
names: Similarity
messages: Belongs to the peptidase C19 family.

6183:Smp 038340
gene id: 6183:Smp_038340
uniprot id: G4VNU4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6183:Smp 196910
gene id: 6183:Smp_196910
uniprot id: G4VB51
names: Similarity
messages: Belongs to the KTI12 family.

6183:Smp 051010
gene id: 6183:Smp_051010
uniprot id: G4VKQ8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 031070.1
gene id: 6183:Smp_031070.1
uniprot id: G4VPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

6183:Smp 178360
gene id: 6183:Smp_178360
uniprot id: G4VPC4
names: Similarity
messages: Belongs to the UFL1 family.

6183:Smp 031720
gene id: 6183:Smp_031720
uniprot id: G4VN61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 165980
gene id: 6183:Smp_165980
uniprot id: G4V8N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

6183:Smp 036500
gene id: 6183:Smp_036500
uniprot id: Q4KXQ2
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 007260.1
gene id: 6183:Smp_007260.1
uniprot id: Q27779
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

6183:Smp 070170
gene id: 6183:Smp_070170
uniprot id: G4VJB5
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 068580.1
gene id: 6183:Smp_068580.1
uniprot id: G4VDP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 004000
gene id: 6183:Smp_004000
uniprot id: G4V6B8
names: Similarity
messages: Belongs to the EIF1AD family.

6183:Smp 012570
gene id: 6183:Smp_012570
uniprot id: G4V978
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

6183:Smp 099870
gene id: 6183:Smp_099870
uniprot id: G4VAD2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

6183:Smp 006710
gene id: 6183:Smp_006710
uniprot id: G4V9V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

6183:Smp 012010
gene id: 6183:Smp_012010
uniprot id: A6XDL3
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 052060
gene id: 6183:Smp_052060
uniprot id: G4VI16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

6183:Smp 046930
gene id: 6183:Smp_046930
uniprot id: G4VCM2
names: Similarity
messages: Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.

6183:Smp 053550.1
gene id: 6183:Smp_053550.1
uniprot id: G4VJ07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

6183:Smp 061560
gene id: 6183:Smp_061560
uniprot id: G4VKK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

6183:Smp 194870
gene id: 6183:Smp_194870
uniprot id: C4QBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 154960.1
gene id: 6183:Smp_154960.1
uniprot id: G4V867
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6183:Smp 004190
gene id: 6183:Smp_004190
uniprot id: G4VCI8
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 003990
gene id: 6183:Smp_003990
uniprot id: G4V6B9
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

6183:Smp 087340
gene id: 6183:Smp_087340
uniprot id: G4VJF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

6183:Smp 201470
gene id: 6183:Smp_201470
uniprot id: G4VBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

6183:Smp 077850
gene id: 6183:Smp_077850
uniprot id: G4VL76
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

6183:Smp 198020
gene id: 6183:Smp_198020
uniprot id: G4VHP5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

6183:Smp 002160
gene id: 6183:Smp_002160
uniprot id: G4VLL1
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 039390
gene id: 6183:Smp_039390
uniprot id: G4VDD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion

6183:Smp 146300
gene id: 6183:Smp_146300
uniprot id: G4VK93
names: Similarity
messages: Belongs to the MT-A70-like family.

6183:Smp 140550
gene id: 6183:Smp_140550
uniprot id: G4V9U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

6183:Smp 069220.1
gene id: 6183:Smp_069220.1
uniprot id: G4VIP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

6183:Smp 059880
gene id: 6183:Smp_059880
uniprot id: G4VT24
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

6183:Smp 005720
gene id: 6183:Smp_005720
uniprot id: G4V740
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6183:Smp 133860
gene id: 6183:Smp_133860
uniprot id: G4VNG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 034410.1
gene id: 6183:Smp_034410.1
uniprot id: G4VBC4
names: Similarity
messages: Belongs to the peptidase C1 family.

6183:Smp 058350
gene id: 6183:Smp_058350
uniprot id: G4VNL4
names: Similarity
messages: Belongs to the PDCD5 family.

6183:Smp 036010
gene id: 6183:Smp_036010
uniprot id: G4VHT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

6183:Smp 142390
gene id: 6183:Smp_142390
uniprot id: G4VE56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6183:Smp 008310
gene id: 6183:Smp_008310
uniprot id: G4V7H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b560 family.
messages: Membrane

6183:Smp 060010
gene id: 6183:Smp_060010
uniprot id: G4VAK6
names: Subcellular Location Annotation
messages: Golgi stack

6183:Smp 039980
gene id: 6183:Smp_039980
uniprot id: G4VKH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

6183:Smp 022560.1
gene id: 6183:Smp_022560.1
uniprot id: G4VEA9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

6183:Smp 008220
gene id: 6183:Smp_008220
uniprot id: G4V7H9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6183:Smp 047640
gene id: 6183:Smp_047640
uniprot id: G4VBG7
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

6183:Smp 156410
gene id: 6183:Smp_156410
uniprot id: G4VA06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

6183:Smp 138240
gene id: 6183:Smp_138240
uniprot id: G4VFH0
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 175230
gene id: 6183:Smp_175230
uniprot id: G4VJD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
messages: Monomer.

6183:Smp 046120
gene id: 6183:Smp_046120
uniprot id: G4VPT0
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 034190.1
gene id: 6183:Smp_034190.1
uniprot id: G4VEF4
names: Similarity
messages: Belongs to the DEAD box helicase family.

6183:Smp 080920.1
gene id: 6183:Smp_080920.1
uniprot id: G4VTE1
uniprot id: G4VTE2
uniprot id: G4VTE3
names: Similarity
messages: Belongs to the profilin family.

6183:Smp 036180
gene id: 6183:Smp_036180
uniprot id: G4V6E6
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

6183:Smp 093690.1
gene id: 6183:Smp_093690.1
uniprot id: G4V9R1
names: Similarity
messages: Belongs to the DEAD box helicase family.

6183:Smp 192110
gene id: 6183:Smp_192110
uniprot id: G4VHK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6183:Smp 058970
gene id: 6183:Smp_058970
uniprot id: G4VJ24
names: Similarity
messages: Belongs to the SDHAF4 family.

6183:Smp 156880
gene id: 6183:Smp_156880
uniprot id: G4VKC5
names: Subcellular Location Annotation
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 011570.1
gene id: 6183:Smp_011570.1
uniprot id: G4VS96
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

6183:Smp 123840
gene id: 6183:Smp_123840
uniprot id: G4V6X4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 062610.1
gene id: 6183:Smp_062610.1
uniprot id: G4VJK8
names: Similarity
messages: Belongs to the ATG101 family.

6183:Smp 082620
gene id: 6183:Smp_082620
uniprot id: G4VC95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

6183:Smp 010370
gene id: 6183:Smp_010370
uniprot id: G4VML4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6183:Smp 029900.1
gene id: 6183:Smp_029900.1
uniprot id: G4VFI9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6183:Smp 194700
gene id: 6183:Smp_194700
uniprot id: G4VGD7
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 007190
gene id: 6183:Smp_007190
uniprot id: G4VB14
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 048760.1
gene id: 6183:Smp_048760.1
uniprot id: G4VBY2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

6183:Smp 038410
gene id: 6183:Smp_038410
uniprot id: G4VNU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Involved in protein trafficking.
messages: Membrane

6183:Smp 019030
gene id: 6183:Smp_019030
uniprot id: G4VG42
names: Similarity
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

6183:Smp 148560.1
gene id: 6183:Smp_148560.1
uniprot id: G4V8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

6183:Smp 072950
gene id: 6183:Smp_072950
uniprot id: G4V9Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6183:Smp 127100
gene id: 6183:Smp_127100
uniprot id: G4VL32
names: Similarity
messages: Belongs to the SUA5 family.

6183:Smp 080530
gene id: 6183:Smp_080530
uniprot id: G4VRN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 2 family.
messages: Nucleus

6183:Smp 118750
gene id: 6183:Smp_118750
uniprot id: G4VPK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

6183:Smp 210450
gene id: 6183:Smp_210450
uniprot id: G4VB00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

6183:Smp 035270.1
gene id: 6183:Smp_035270.1
uniprot id: G4V7Z7
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

6183:Smp 066340.1
gene id: 6183:Smp_066340.1
uniprot id: G4VGG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm

6183:Smp 180000
gene id: 6183:Smp_180000
uniprot id: G4VTQ8
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

6183:Smp 128200.1
gene id: 6183:Smp_128200.1
uniprot id: G4VD81
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

6183:Smp 023160
gene id: 6183:Smp_023160
uniprot id: G4VCC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

6183:Smp 151020
gene id: 6183:Smp_151020
uniprot id: G4VHQ1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 080980.1
gene id: 6183:Smp_080980.1
uniprot id: G4VTF1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 054340.1
gene id: 6183:Smp_054340.1
uniprot id: G4VQK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

6183:Smp 097370
gene id: 6183:Smp_097370
uniprot id: G4VML1
names: Similarity
messages: Belongs to the FBPase class 1 family.

6183:Smp 011230
gene id: 6183:Smp_011230
uniprot id: G4VD88
names: Function
names: Similarity
messages: Belongs to the peptidase C13 family.
messages: Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.

6183:Smp 171720
gene id: 6183:Smp_171720
uniprot id: G4VJ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

6183:Smp 045260
gene id: 6183:Smp_045260
uniprot id: G4VBS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

6183:Smp 068420
gene id: 6183:Smp_068420
uniprot id: Q4JHT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

6183:Smp 084060
gene id: 6183:Smp_084060
uniprot id: G4VRF4
names: Similarity
messages: Belongs to the MS4A family.

6183:Smp 042030.1
gene id: 6183:Smp_042030.1
uniprot id: G4VJS4
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 024180.1
gene id: 6183:Smp_024180.1
uniprot id: G4VQ69
names: Similarity
messages: Belongs to the cornifelin family.

6183:Smp 078730
gene id: 6183:Smp_078730
uniprot id: G4VFD7
names: Similarity
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

6183:Smp 022850.1
gene id: 6183:Smp_022850.1
uniprot id: G4VQ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS31 family.
messages: Mitochondrion

6183:Smp 147370
gene id: 6183:Smp_147370
uniprot id: G4VNB1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 095520
gene id: 6183:Smp_095520
uniprot id: Q94758
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Acts as a non-catalytic accessory component of a dynein complex.
messages: Belongs to the dynein light chain family.
messages: Schistosomula, lung stage worms, and adult worms.
messages: Tegument.
messages: cytoskeleton

6183:Smp 006340
gene id: 6183:Smp_006340
uniprot id: G4VR33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 084890
gene id: 6183:Smp_084890
uniprot id: G4VFF8
names: Similarity
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

6183:Smp 180060
gene id: 6183:Smp_180060
uniprot id: G4VRU9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane

6183:Smp 046740
gene id: 6183:Smp_046740
uniprot id: G4VCN8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

6183:Smp 092280
gene id: 6183:Smp_092280
uniprot id: G4VHX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 015730
gene id: 6183:Smp_015730
uniprot id: G4VSL8
names: Similarity
messages: Belongs to the complex I NDUFB6 subunit family.

6183:Smp 154680
gene id: 6183:Smp_154680
uniprot id: G4V6I0
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

6183:Smp 022640
gene id: 6183:Smp_022640
uniprot id: G4V5V3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

6183:Smp 181100
gene id: 6183:Smp_181100
uniprot id: Q15ES2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

6183:Smp 069810
gene id: 6183:Smp_069810
uniprot id: G4VK58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM129 family.
messages: Membrane

6183:Smp 071470
gene id: 6183:Smp_071470
uniprot id: G4V9K3
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 073720.1
gene id: 6183:Smp_073720.1
uniprot id: G4V6Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: cytoskeleton

6183:Smp 076040.1
gene id: 6183:Smp_076040.1
uniprot id: B8Y6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

6183:Smp 012970
gene id: 6183:Smp_012970
uniprot id: G4VEX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

6183:Smp 170030
gene id: 6183:Smp_170030
uniprot id: G4VTS1
names: Similarity
messages: Belongs to the SH3BGR family.

6183:Smp 089240
gene id: 6183:Smp_089240
uniprot id: G4VAB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

6183:Smp 027300
gene id: 6183:Smp_027300
uniprot id: G4VHB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Nucleus
messages: centromere

6183:Smp 174320
gene id: 6183:Smp_174320
uniprot id: G4VRL8
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 070330
gene id: 6183:Smp_070330
uniprot id: G4VTA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

6183:Smp 165950
gene id: 6183:Smp_165950
uniprot id: G4V8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

6183:Smp 074390
gene id: 6183:Smp_074390
uniprot id: G4VLC5
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

6183:Smp 038030
gene id: 6183:Smp_038030
uniprot id: G4VQX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

6183:Smp 166930
gene id: 6183:Smp_166930
uniprot id: G4VC98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Lysosome membrane

6183:Smp 073790
gene id: 6183:Smp_073790
uniprot id: G4V6Z2
names: Similarity
messages: Belongs to the ATG8 family.

6183:KEF69 p12
gene id: 6183:KEF69_p12
uniprot id: Q9B8X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 013470.1
gene id: 6183:Smp_013470.1
uniprot id: G4VH46
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

6183:Smp 070780
gene id: 6183:Smp_070780
uniprot id: G4VEM1
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

6183:Smp 022570.1
gene id: 6183:Smp_022570.1
uniprot id: G4VEB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of some SAGA transcription coactivator-HAT complexes.
messages: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.
messages: Nucleus

6183:Smp 004630
gene id: 6183:Smp_004630
uniprot id: G4VHD5
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 015020
gene id: 6183:Smp_015020
uniprot id: G4VGA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 040130
gene id: 6183:Smp_040130
uniprot id: Q26565
names: Activity Regulation
names: Function
names: Similarity
names: Tissue Specificity
messages: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Found mainly in the tegument, gut epithelium, and muscle layers. Also found in the interior of the parasite.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6183:Smp 096720
gene id: 6183:Smp_096720
uniprot id: G4VJE1
names: Similarity
messages: Belongs to the WD repeat WDR91 family.

6183:Smp 015720
gene id: 6183:Smp_015720
uniprot id: G4VSL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

6183:Smp 011710
gene id: 6183:Smp_011710
uniprot id: G4VSZ6
names: Similarity
messages: Belongs to the AAR2 family.

6183:Smp 031010
gene id: 6183:Smp_031010
uniprot id: G4VPJ1
names: Similarity
messages: Belongs to the DEAD box helicase family.

6183:Smp 203170
gene id: 6183:Smp_203170
uniprot id: G4VMC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 054360
gene id: 6183:Smp_054360
uniprot id: G4VQJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

6183:Smp 093950
gene id: 6183:Smp_093950
uniprot id: G4VB33
names: Similarity
messages: Belongs to the peptidase C85 family.

6183:Smp 038960
gene id: 6183:Smp_038960
uniprot id: G4VQZ4
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

6183:Smp 166420
gene id: 6183:Smp_166420
uniprot id: G4VDR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

6183:Smp 060240
gene id: 6183:Smp_060240
uniprot id: G4VQL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6183:Smp 126080
gene id: 6183:Smp_126080
uniprot id: G4VB17
names: Similarity
messages: Belongs to the arrestin family.

6183:Smp 158520
gene id: 6183:Smp_158520
uniprot id: G4V6S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

6183:Smp 066890
gene id: 6183:Smp_066890
uniprot id: G4VIL3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

6183:Smp 053040
gene id: 6183:Smp_053040
uniprot id: G4VK08
names: Similarity
messages: Belongs to the SNF7 family.

6183:Smp 150160
gene id: 6183:Smp_150160
uniprot id: G4VI00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

6183:Smp 035730
gene id: 6183:Smp_035730
uniprot id: G4VHK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

6183:Smp 027220
gene id: 6183:Smp_027220
uniprot id: G4VHC5
names: Similarity
messages: Belongs to the OPI10 family.

6183:Smp 061500
gene id: 6183:Smp_061500
uniprot id: G4VKK8
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.

6183:Smp 003410
gene id: 6183:Smp_003410
uniprot id: G4V6P4
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

6183:Smp 129760
gene id: 6183:Smp_129760
uniprot id: G4VS32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

6183:Smp 071570
gene id: 6183:Smp_071570
uniprot id: G4V9J2
names: Similarity
messages: Belongs to the TFIIB family.

6183:Smp 017070
gene id: 6183:Smp_017070
uniprot id: G4VTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 146800
gene id: 6183:Smp_146800
uniprot id: G4VPP5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

6183:Smp 020040.1
gene id: 6183:Smp_020040.1
uniprot id: G4V8G1
uniprot id: G4V8G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

6183:Smp 136320
gene id: 6183:Smp_136320
uniprot id: G4VJX1
names: Similarity
messages: Belongs to the GSKIP family.

6183:Smp 030180
gene id: 6183:Smp_030180
uniprot id: G4VFM6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.
messages: Cytoplasm

6183:Smp 171620
gene id: 6183:Smp_171620
uniprot id: G4VP86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

6183:Smp 038950
gene id: 6183:Smp_038950
uniprot id: G4VQZ5
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

6183:Smp 049270
gene id: 6183:Smp_049270
uniprot id: G4V8X9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6183:Smp 154270
gene id: 6183:Smp_154270
uniprot id: G4VMD4
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

6183:Smp 186710
gene id: 6183:Smp_186710
uniprot id: G4VLD8
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.

6183:Smp 064150
gene id: 6183:Smp_064150
uniprot id: G4VCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 143740
gene id: 6183:Smp_143740
uniprot id: G4VSS2
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

6183:Smp 169610
gene id: 6183:Smp_169610
uniprot id: G4VJH0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6183:Smp 031270.1
gene id: 6183:Smp_031270.1
uniprot id: G4VPM2
uniprot id: G4VPM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

6183:Smp 073570
gene id: 6183:Smp_073570
uniprot id: G4V787
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

6183:Smp 032520.1
gene id: 6183:Smp_032520.1
uniprot id: G4VSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

6183:Smp 021750.1
gene id: 6183:Smp_021750.1
uniprot id: G4VDU5
names: Similarity
messages: Belongs to the methyltransferase superfamily.

6183:Smp 089570
gene id: 6183:Smp_089570
uniprot id: G4V5T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane

6183:Smp 022430
gene id: 6183:Smp_022430
uniprot id: G4VPA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 127940
gene id: 6183:Smp_127940
uniprot id: G4VMR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

6183:Smp 030250
gene id: 6183:Smp_030250
uniprot id: Q26561
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

6183:Smp 075130
gene id: 6183:Smp_075130
uniprot id: G4VGZ9
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

6183:Smp 179250
gene id: 6183:Smp_179250
uniprot id: G4VLD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

6183:Smp 210720
gene id: 6183:Smp_210720
uniprot id: G4VFA0
names: Similarity
messages: Belongs to the UPF0047 family.

6183:Smp 054410
gene id: 6183:Smp_054410
uniprot id: G4VQJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

6183:Smp 008440
gene id: 6183:Smp_008440
uniprot id: G4V5H2
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

6183:Smp 032790
gene id: 6183:Smp_032790
uniprot id: G4VDI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMDT1/EMRE family.
messages: Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.
messages: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 096480
gene id: 6183:Smp_096480
uniprot id: G4VR43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Membrane

6183:Smp 045200
gene id: 6183:Smp_045200
uniprot id: P14202
names: Developmental Stage
names: Tissue Specificity
messages: Adult and schistosomula tegument.
messages: This antigen occurs in adults and sporocysts but not in cercariae, eggs or newly transformed schistosomula. It is a developmentally regulated protein.

6183:Smp 210830
gene id: 6183:Smp_210830
uniprot id: G4V8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

6183:Smp 087940.1
gene id: 6183:Smp_087940.1
uniprot id: G4VLS0
names: Similarity
messages: Belongs to the ATG8 family.

6183:Smp 045550
gene id: 6183:Smp_045550
uniprot id: G4VI63
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6183:Smp 102450
gene id: 6183:Smp_102450
uniprot id: G4VP84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
messages: nucleolus

6183:Smp 007760
gene id: 6183:Smp_007760
uniprot id: G4VPX8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

6183:Smp 160780
gene id: 6183:Smp_160780
uniprot id: G4V7X8
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 044440
gene id: 6183:Smp_044440
uniprot id: G4VR32
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

6183:Smp 047610
gene id: 6183:Smp_047610
uniprot id: G4VBH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

6183:Smp 012470
gene id: 6183:Smp_012470
uniprot id: G4V969
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

6183:Smp 048940
gene id: 6183:Smp_048940
uniprot id: G4VBZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Late endosome membrane

6183:Smp 123010
gene id: 6183:Smp_123010
uniprot id: G4VCH8
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 203810
gene id: 6183:Smp_203810
uniprot id: G4VQL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6183:Smp 002180.1
gene id: 6183:Smp_002180.1
uniprot id: G4VLL3
names: Similarity
messages: Belongs to the NAC-beta family.

6183:Smp 129110.1
gene id: 6183:Smp_129110.1
uniprot id: G4VEX0
uniprot id: G4VEX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

6183:Smp 115340
gene id: 6183:Smp_115340
uniprot id: G4VG91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

6183:Smp 087270
gene id: 6183:Smp_087270
uniprot id: G4VJG1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

6183:Smp 005790
gene id: 6183:Smp_005790
uniprot id: G4V734
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

6183:Smp 050740
gene id: 6183:Smp_050740
uniprot id: G4VIA6
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 025160.1
gene id: 6183:Smp_025160.1
uniprot id: G4VPG3
uniprot id: O18501
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

6183:Smp 177080
gene id: 6183:Smp_177080
uniprot id: G4VG79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

6183:Smp 050590
gene id: 6183:Smp_050590
uniprot id: G4VHI6
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

6183:Smp 024010
gene id: 6183:Smp_024010
uniprot id: G4VQ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

6183:Smp 157680
gene id: 6183:Smp_157680
uniprot id: G4VPB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

6183:Smp 158910
gene id: 6183:Smp_158910
uniprot id: G4VHW3
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

6183:Smp 059870.1
gene id: 6183:Smp_059870.1
uniprot id: G4VT25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

6183:Smp 127710
gene id: 6183:Smp_127710
uniprot id: G4VMM4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 120980
gene id: 6183:Smp_120980
uniprot id: G4VFM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

6183:Smp 121320
gene id: 6183:Smp_121320
uniprot id: G4VAT9
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in spermatogenesis.
messages: Nucleus

6183:Smp 007500.1
gene id: 6183:Smp_007500.1
uniprot id: G4VF21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Membrane

6183:Smp 104720
gene id: 6183:Smp_104720
uniprot id: C1M169
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

6183:Smp 010690
gene id: 6183:Smp_010690
uniprot id: G4VMP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

6183:Smp 145290
gene id: 6183:Smp_145290
uniprot id: G4VIT0
names: Similarity
messages: Belongs to the alkaline phosphatase family.

6183:Smp 032810
gene id: 6183:Smp_032810
uniprot id: G4VDI4
names: Similarity
messages: Belongs to the thymidylate kinase family.

6183:Smp 024120
gene id: 6183:Smp_024120
uniprot id: O01374
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane
messages: Was originally thought to be the ubiquinone-binding protein (QP-C).

6183:Smp 020050
gene id: 6183:Smp_020050
uniprot id: G4V8G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 051070
gene id: 6183:Smp_051070
uniprot id: G4VKR4
names: Similarity
messages: Belongs to the gonadal family.

6183:Smp 098330
gene id: 6183:Smp_098330
uniprot id: G4V8R9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

6183:Smp 024060.1
gene id: 6183:Smp_024060.1
uniprot id: G4VQ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 045710.1
gene id: 6183:Smp_045710.1
uniprot id: G4VK88
names: Similarity
messages: Belongs to the SNF7 family.

6183:Smp 021800
gene id: 6183:Smp_021800
uniprot id: G4VDV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

6183:Smp 136360
gene id: 6183:Smp_136360
uniprot id: G4VEY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

6183:Smp 069240
gene id: 6183:Smp_069240
uniprot id: Q26597
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 042550
gene id: 6183:Smp_042550
uniprot id: G4VRE2
names: Similarity
messages: Belongs to the sorting nexin family.

6183:Smp 016670
gene id: 6183:Smp_016670
uniprot id: G4VKX2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

6183:Smp 029740
gene id: 6183:Smp_029740
uniprot id: G4VFH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

6183:Smp 003930
gene id: 6183:Smp_003930
uniprot id: G4V6C8
names: Similarity
messages: Belongs to the IFT56 family.

6183:Smp 043320
gene id: 6183:Smp_043320
uniprot id: G4VIY7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6183:Smp 084090
gene id: 6183:Smp_084090
uniprot id: G4VRF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 095910
gene id: 6183:Smp_095910
uniprot id: G4VDN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

6183:Smp 089870
gene id: 6183:Smp_089870
uniprot id: G4VCW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 045930
gene id: 6183:Smp_045930
uniprot id: G4VPQ7
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 055670
gene id: 6183:Smp_055670
uniprot id: G4VHJ2
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

6183:Smp 052280.1
gene id: 6183:Smp_052280.1
uniprot id: G4VHZ6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

6183:Smp 047370
gene id: 6183:Smp_047370
uniprot id: G4VBJ0
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

6183:Smp 053830
gene id: 6183:Smp_053830
uniprot id: G4VHS0
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

6183:Smp 074230
gene id: 6183:Smp_074230
uniprot id: G4VLA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

6183:Smp 145140
gene id: 6183:Smp_145140
uniprot id: G4VJE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

6183:Smp 146190
gene id: 6183:Smp_146190
uniprot id: G4VQS2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS21 family.

6183:Smp 047660
gene id: 6183:Smp_047660
uniprot id: G4VBG5
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

6183:Smp 210250
gene id: 6183:Smp_210250
uniprot id: G4VDJ0
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

6183:Smp 012050
gene id: 6183:Smp_012050
uniprot id: G4VS05
names: Similarity
messages: Belongs to the BolA/IbaG family.

6183:Smp 103140
gene id: 6183:Smp_103140
uniprot id: Q26444
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6183:Smp 032820.1
gene id: 6183:Smp_032820.1
uniprot id: G4VDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

6183:Smp 160210
gene id: 6183:Smp_160210
uniprot id: G4VJB9
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

6183:Smp 002880.1
gene id: 6183:Smp_002880.1
uniprot id: G4VLJ0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

6183:Smp 046550
gene id: 6183:Smp_046550
uniprot id: G4VLV8
names: Similarity
messages: Belongs to the bystin family.

6183:Smp 210440
gene id: 6183:Smp_210440
uniprot id: G4VAZ9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6183:Smp 019010
gene id: 6183:Smp_019010
uniprot id: G4VG40
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

6183:Smp 158190
gene id: 6183:Smp_158190
uniprot id: G4VM07
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 148510
gene id: 6183:Smp_148510
uniprot id: G4VC21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

6183:Smp 179660
gene id: 6183:Smp_179660
uniprot id: G4VDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane

6183:Smp 126110
gene id: 6183:Smp_126110
uniprot id: G4VB10
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Cytoplasm
messages: centrosome
messages: spindle
messages: spindle pole

6183:Smp 151510
gene id: 6183:Smp_151510
uniprot id: G4VH69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

6183:Smp 104580
gene id: 6183:Smp_104580
uniprot id: G4VE51
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

6183:Smp 031000.1
gene id: 6183:Smp_031000.1
uniprot id: G4VPI9
names: Similarity
messages: Belongs to the cullin family.

6183:Smp 047650
gene id: 6183:Smp_047650
uniprot id: G4VBG6
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

6183:Smp 002010
gene id: 6183:Smp_002010
uniprot id: G4VLH6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

6183:Smp 140580
gene id: 6183:Smp_140580
uniprot id: G4V9U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

6183:Smp 012800
gene id: 6183:Smp_012800
uniprot id: G4V9G9
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 048520.1
gene id: 6183:Smp_048520.1
uniprot id: G4VSC2
names: Similarity
messages: Belongs to the UPP synthase family.

6183:Smp 007290
gene id: 6183:Smp_007290
uniprot id: G4VB04
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

6183:Smp 067250.1
gene id: 6183:Smp_067250.1
uniprot id: G4V9P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

6183:Smp 067090
gene id: 6183:Smp_067090
uniprot id: G4V5C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

6183:Smp 083080.1
gene id: 6183:Smp_083080.1
uniprot id: G4V7D8
names: Similarity
messages: Belongs to the AHA1 family.

6183:Smp 126520
gene id: 6183:Smp_126520
uniprot id: G4VN39
names: Similarity
messages: Belongs to the STAM family.

6183:Smp 202170
gene id: 6183:Smp_202170
uniprot id: G4VFW0
names: Similarity
messages: Belongs to the GTR/RAG GTP-binding protein family.

6183:Smp 050940.1
gene id: 6183:Smp_050940.1
uniprot id: G4VMJ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

6183:Smp 079920
gene id: 6183:Smp_079920
uniprot id: G4VT40
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

6183:Smp 060220
gene id: 6183:Smp_060220
uniprot id: G4VQL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6183:Smp 013070
gene id: 6183:Smp_013070
uniprot id: G4VEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

6183:Smp 194770
gene id: 6183:Smp_194770
uniprot id: P16641
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Expressed at low levels in 37-day sporocysts, increases 25-fold in the infective cercarial and early schistosomular stages. Levels decrease dramatically in adults, adult males have approximately twice the expression level as in adult females.
messages: This family of enzymes reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).

6183:Smp 054010
gene id: 6183:Smp_054010
uniprot id: G4VHR0
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 052760
gene id: 6183:Smp_052760
uniprot id: G4VM34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

6183:Smp 005000
gene id: 6183:Smp_005000
uniprot id: G4V5L5
names: Similarity
messages: Belongs to the NECAP family.

6183:Smp 079710
gene id: 6183:Smp_079710
uniprot id: G4VFB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Mitochondrion inner membrane

6183:Smp 012930
gene id: 6183:Smp_012930
uniprot id: G4V9I5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

6183:Smp 159150.1
gene id: 6183:Smp_159150.1
uniprot id: G4VAE9
names: Similarity
messages: Belongs to the TEX28 family.

6183:Smp 084910
gene id: 6183:Smp_084910
uniprot id: G4VFF6
names: Similarity
messages: Belongs to the FMC1 family.

6183:Smp 041650
gene id: 6183:Smp_041650
uniprot id: G4VN01
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.

6183:Smp 088600
gene id: 6183:Smp_088600
uniprot id: G4VDJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 029820
gene id: 6183:Smp_029820
uniprot id: G4VFI4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

6183:Smp 029700
gene id: 6183:Smp_029700
uniprot id: G4VFH1
names: Similarity
messages: Belongs to the NKAP family.

6183:Smp 130850
gene id: 6183:Smp_130850
uniprot id: G4VJN9
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

6183:Smp 126670
gene id: 6183:Smp_126670
uniprot id: G4V7G3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

6183:Smp 010620.1
gene id: 6183:Smp_010620.1
uniprot id: G4VMN6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

6183:Smp 112520
gene id: 6183:Smp_112520
uniprot id: G4VPC5
names: Similarity
messages: Belongs to the UFL1 family.

6183:Smp 168330
gene id: 6183:Smp_168330
uniprot id: G4VES0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

6183:Smp 071140
gene id: 6183:Smp_071140
uniprot id: G4V7X9
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

6183:Smp 016340
gene id: 6183:Smp_016340
uniprot id: G4VHF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 073590
gene id: 6183:Smp_073590
uniprot id: G4V709
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

6183:Smp 022960
gene id: 6183:Smp_022960
uniprot id: G4VN20
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

6183:Smp 141330
gene id: 6183:Smp_141330
uniprot id: G4V7P9
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

6183:Smp 028060
gene id: 6183:Smp_028060
uniprot id: G4V631
names: Similarity
messages: Belongs to the SURF6 family.

6183:Smp 076030.1
gene id: 6183:Smp_076030.1
uniprot id: G4VSU0
names: Similarity
messages: Belongs to the BTG family.

6183:Smp 146310
gene id: 6183:Smp_146310
uniprot id: G4VBJ7
names: Similarity
messages: Belongs to the exonuclease superfamily. TREX family.

6183:Smp 091740.1
gene id: 6183:Smp_091740.1
uniprot id: G4VLM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

6183:Smp 140180
gene id: 6183:Smp_140180
uniprot id: G4VMT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6183:Smp 046680
gene id: 6183:Smp_046680
uniprot id: G4VCP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

6183:Smp 090150.1
gene id: 6183:Smp_090150.1
uniprot id: G4VHV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

6183:Smp 079240
gene id: 6183:Smp_079240
uniprot id: G4V790
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

6183:Smp 056370
gene id: 6183:Smp_056370
uniprot id: G4VSX8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

6183:Smp 066520
gene id: 6183:Smp_066520
uniprot id: G4VM02
names: Similarity
messages: Belongs to the band 7/mec-2 family.

6183:Smp 046900
gene id: 6183:Smp_046900
uniprot id: G4VCL9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 091170
gene id: 6183:Smp_091170
uniprot id: G4VRI9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

6183:Smp 082490
gene id: 6183:Smp_082490
uniprot id: G4VGI8
names: Similarity
messages: Belongs to the cyclin family.

6183:Smp 130630
gene id: 6183:Smp_130630
uniprot id: G4VSD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

6183:Smp 080100
gene id: 6183:Smp_080100
uniprot id: G4VJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

6183:Smp 055050
gene id: 6183:Smp_055050
uniprot id: G4VH80
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

6183:Smp 106050
gene id: 6183:Smp_106050
uniprot id: G4VEN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

6183:Smp 012750
gene id: 6183:Smp_012750
uniprot id: G4V9G5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Binds directly to 26S ribosomal RNA.

6183:Smp 085380
gene id: 6183:Smp_085380
uniprot id: G4VRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 024520
gene id: 6183:Smp_024520
uniprot id: G4VC26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

6183:Smp 028070.1
gene id: 6183:Smp_028070.1
uniprot id: G4V630
names: Similarity
messages: Belongs to the BicD family.

6183:Smp 085750
gene id: 6183:Smp_085750
uniprot id: G4VF33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

6183:Smp 093670
gene id: 6183:Smp_093670
uniprot id: G4V9Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

6183:Smp 055190
gene id: 6183:Smp_055190
uniprot id: G4VH67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 056200
gene id: 6183:Smp_056200
uniprot id: G4V5Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Mitochondrion

6183:Smp 037120
gene id: 6183:Smp_037120
uniprot id: G4VRH7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

6183:Smp 013300.1
gene id: 6183:Smp_013300.1
uniprot id: G4VEH8
uniprot id: G4VEH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

6183:Smp 070680
gene id: 6183:Smp_070680
uniprot id: G4VEL0
names: Similarity
messages: Belongs to the MAF1 family.

6183:Smp 059670
gene id: 6183:Smp_059670
uniprot id: G4VMD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

6183:Smp 054470
gene id: 6183:Smp_054470
uniprot id: Q6B963
names: Similarity
messages: Belongs to the thioredoxin family.

6183:Smp 010900
gene id: 6183:Smp_010900
uniprot id: G4VMR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

6183:Smp 064750.1
gene id: 6183:Smp_064750.1
uniprot id: G4VQ30
names: Subunit
messages: Homodimer. Interacts with PKM.

6183:Smp 009520
gene id: 6183:Smp_009520
uniprot id: G4V9R9
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

6183:Smp 142490
gene id: 6183:Smp_142490
uniprot id: G4VE75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

6183:Smp 001170
gene id: 6183:Smp_001170
uniprot id: G4V5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

6183:Smp 017660
gene id: 6183:Smp_017660
uniprot id: C1LZ83
names: Similarity
messages: Belongs to the PA28 family.

6183:Smp 031770.1
gene id: 6183:Smp_031770.1
uniprot id: G4VN65
uniprot id: G4VN73
uniprot id: G4VN74
uniprot id: G4VN76
uniprot id: G4VN78
uniprot id: P42638
names: Domain
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Associated with the protective tegument surrounding the sporocyst.
messages: Belongs to the tropomyosin family.
messages: Homodimer.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

6183:Smp 075120
gene id: 6183:Smp_075120
uniprot id: G4VH00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

6183:Smp 035470
gene id: 6183:Smp_035470
uniprot id: G4V7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

6183:Smp 042160.1
gene id: 6183:Smp_042160.1
uniprot id: P53442
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

6183:Smp 075560
gene id: 6183:Smp_075560
uniprot id: G4VT90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

6183:Smp 196790
gene id: 6183:Smp_196790
uniprot id: Q6BC92
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

6183:Smp 079770.1
gene id: 6183:Smp_079770.1
uniprot id: G4VFC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

6183:Smp 168930
gene id: 6183:Smp_168930
uniprot id: G4V875
names: Subcellular Location Annotation
messages: Golgi apparatus membrane

6183:Smp 039400
gene id: 6183:Smp_039400
uniprot id: G4VDD2
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

6183:Smp 149360
gene id: 6183:Smp_149360
uniprot id: G4VMI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Homodimer.
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: cis-Golgi network

6183:Smp 017890
gene id: 6183:Smp_017890
uniprot id: G4VNY2
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 055740
gene id: 6183:Smp_055740
uniprot id: G4VHK0
names: Similarity
messages: Belongs to the nanos family.

6183:Smp 083720
gene id: 6183:Smp_083720
uniprot id: G4V6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 076660
gene id: 6183:Smp_076660
uniprot id: G4V7L5
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

6183:Smp 035030
gene id: 6183:Smp_035030
uniprot id: G4V825
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

6183:Smp 021540
gene id: 6183:Smp_021540
uniprot id: G4VNH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

6183:Smp 018460
gene id: 6183:Smp_018460
uniprot id: G4VGN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

6183:Smp 068080
gene id: 6183:Smp_068080
uniprot id: G4V6P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

6183:KEF69 p07
gene id: 6183:KEF69_p07
uniprot id: Q9B8X5
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 079960
gene id: 6183:Smp_079960
uniprot id: G4VTA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

6183:Smp 044010.1
gene id: 6183:Smp_044010.1
uniprot id: P42637
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tropomyosin family.
messages: Expressed at much higher levels in the adult worm stage as compared to the cercariae and the egg stages.
messages: Homodimer.
messages: The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
messages: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

6183:Smp 026300
gene id: 6183:Smp_026300
uniprot id: G4VEY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

6183:Smp 092780.1
gene id: 6183:Smp_092780.1
uniprot id: G4V6J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

6183:Smp 129750
gene id: 6183:Smp_129750
uniprot id: G4VS29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

6183:Smp 086590
gene id: 6183:Smp_086590
uniprot id: G4VGX1
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

6183:Smp 093750.1
gene id: 6183:Smp_093750.1
uniprot id: Q95W35
names: Similarity
messages: Belongs to the eIF-2-alpha family.

6183:Smp 012440
gene id: 6183:Smp_012440
uniprot id: Q26579
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

6183:Smp 038630
gene id: 6183:Smp_038630
uniprot id: G4VI93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 049170
gene id: 6183:Smp_049170
uniprot id: G4VC17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.

6183:Smp 180800
gene id: 6183:Smp_180800
uniprot id: G4V6G6
names: Similarity
messages: Belongs to the learning-associated protein family.

6183:Smp 004070
gene id: 6183:Smp_004070
uniprot id: G4V6B2
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

6183:Smp 025860
gene id: 6183:Smp_025860
uniprot id: G4VAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: cytoskeleton

6183:Smp 043150
gene id: 6183:Smp_043150
uniprot id: Q04702
names: Similarity
messages: Belongs to the calreticulin family.

6183:Smp 055450
gene id: 6183:Smp_055450
uniprot id: G4V5W4
names: Similarity
messages: Belongs to the LAMTOR4 family.

6183:Smp 083130
gene id: 6183:Smp_083130
uniprot id: G4V7E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

6183:Smp 103200
gene id: 6183:Smp_103200
uniprot id: G4VGY6
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

6183:Smp 064520
gene id: 6183:Smp_064520
uniprot id: G4VKB5
names: Similarity
messages: Belongs to the MIP18 family.

6183:Smp 134880
gene id: 6183:Smp_134880
uniprot id: G4VFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

6183:Smp 049300.1
gene id: 6183:Smp_049300.1
uniprot id: G4V8Y7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

6183:Smp 046250
gene id: 6183:Smp_046250
uniprot id: G4VE02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

6183:Smp 088720
gene id: 6183:Smp_088720
uniprot id: G4VDQ3
names: Similarity
messages: Belongs to the CIA30 family.

6183:Smp 058140.1
gene id: 6183:Smp_058140.1
uniprot id: G4VK44
uniprot id: G4VK45
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

6183:Smp 093230
gene id: 6183:Smp_093230
uniprot id: G4V8Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: cytoskeleton

6183:Smp 086860
gene id: 6183:Smp_086860
uniprot id: G4V8L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 096290.1
gene id: 6183:Smp_096290.1
uniprot id: G4VS51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

6183:Smp 150040.1
gene id: 6183:Smp_150040.1
uniprot id: G4VI20
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

6183:Smp 053390
gene id: 6183:Smp_053390
uniprot id: C4QBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 025800
gene id: 6183:Smp_025800
uniprot id: G4VAQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

6183:Smp 068270.1
gene id: 6183:Smp_068270.1
uniprot id: G4VTC5
uniprot id: G4VTC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

6183:Smp 073500.1
gene id: 6183:Smp_073500.1
uniprot id: G4V780
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

6183:KEF69 p01
gene id: 6183:KEF69_p01
uniprot id: Q9B8X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 078640
gene id: 6183:Smp_078640
uniprot id: G4V9Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

6183:Smp 169870
gene id: 6183:Smp_169870
uniprot id: G4VMC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

6183:Smp 092390
gene id: 6183:Smp_092390
uniprot id: G4VHY4
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

6183:Smp 058320
gene id: 6183:Smp_058320
uniprot id: G4VNL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

6183:Smp 051080
gene id: 6183:Smp_051080
uniprot id: G4VKR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

6183:Smp 025550
gene id: 6183:Smp_025550
uniprot id: G4VPC6
names: Function
names: Similarity
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.

6183:Smp 008260
gene id: 6183:Smp_008260
uniprot id: G4V7H6
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

6183:Smp 015710
gene id: 6183:Smp_015710
uniprot id: G4VSL5
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

6183:Smp 011150
gene id: 6183:Smp_011150
uniprot id: G4VD96
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

6183:Smp 004640
gene id: 6183:Smp_004640
uniprot id: G4VD46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Virion

6183:Smp 085110.1
gene id: 6183:Smp_085110.1
uniprot id: G4VES1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

6183:Smp 093280
gene id: 6183:Smp_093280
uniprot id: A5H659
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

6183:Smp 009390.1
gene id: 6183:Smp_009390.1
uniprot id: G4VL14
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

6183:Smp 027370
gene id: 6183:Smp_027370
uniprot id: G4VHA9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 092850.1
gene id: 6183:Smp_092850.1
uniprot id: G4V6G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

6183:Smp 113620.1
gene id: 6183:Smp_113620.1
uniprot id: G4VBT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

6183:Smp 200020
gene id: 6183:Smp_200020
uniprot id: G4V8Z0
names: Similarity
messages: Belongs to the yippee family.

6183:Smp 060180
gene id: 6183:Smp_060180
uniprot id: G4VQM9
names: Similarity
messages: Belongs to the WD repeat SEC13 family.

6183:Smp 201760
gene id: 6183:Smp_201760
uniprot id: G4VBT9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6183:Smp 068110
gene id: 6183:Smp_068110
uniprot id: G4V6Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

6183:Smp 211090
gene id: 6183:Smp_211090
uniprot id: G4VBH5
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

6183:Smp 082850.1
gene id: 6183:Smp_082850.1
uniprot id: G4VC71
names: Similarity
messages: Belongs to the cullin family.

6183:Smp 163850
gene id: 6183:Smp_163850
uniprot id: G4VTL9
names: Similarity
messages: Belongs to the TIP41 family.

6183:Smp 170840
gene id: 6183:Smp_170840
uniprot id: G4VLE1
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.

6183:Smp 014780.1
gene id: 6183:Smp_014780.1
uniprot id: G4VBW4
names: Similarity
messages: Belongs to the alpha-actinin family.

6183:Smp 040680
gene id: 6183:Smp_040680
uniprot id: G4VB75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6183:Smp 034100
gene id: 6183:Smp_034100
uniprot id: Q15ES4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

6183:Smp 090230
gene id: 6183:Smp_090230
uniprot id: G4VQW2
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

6183:Smp 121790.1
gene id: 6183:Smp_121790.1
uniprot id: G4VGE1
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

6183:KEF69 p11
gene id: 6183:KEF69_p11
uniprot id: Q9MD49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

6183:Smp 073680.1
gene id: 6183:Smp_073680.1
uniprot id: G4V701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

6183:Smp 079640
gene id: 6183:Smp_079640
uniprot id: G4V7W3
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 064950
gene id: 6183:Smp_064950
uniprot id: G4VPT6
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

6183:Smp 136970
gene id: 6183:Smp_136970
uniprot id: G4VHB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

6183:Smp 090860
gene id: 6183:Smp_090860
uniprot id: G4V8L2
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

6183:Smp 092880.1
gene id: 6183:Smp_092880.1
uniprot id: G4VE77
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 096900
gene id: 6183:Smp_096900
uniprot id: G4VBL5
names: Similarity
messages: Belongs to the PPR family. P subfamily.

6183:Smp 210790
gene id: 6183:Smp_210790
uniprot id: G4V7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

6183:Smp 083040.1
gene id: 6183:Smp_083040.1
uniprot id: G4V775
uniprot id: G4V776
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

6183:Smp 181470
gene id: 6183:Smp_181470
uniprot id: G4VEN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

6183:Smp 016130
gene id: 6183:Smp_016130
uniprot id: G4V5G1
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

6183:Smp 052870
gene id: 6183:Smp_052870
uniprot id: G4VGE8
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

6183:Smp 083150.1
gene id: 6183:Smp_083150.1
uniprot id: G4V7E6
names: Similarity
messages: Belongs to the GPATCH11 family.

6183:Smp 017280
gene id: 6183:Smp_017280
uniprot id: Q15ER5
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

6183:Smp 171660
gene id: 6183:Smp_171660
uniprot id: G4VP78
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 207070
gene id: 6183:Smp_207070
uniprot id: G4VLZ9
names: Similarity
messages: Belongs to the uridine kinase family.

6183:Smp 014080
gene id: 6183:Smp_014080
uniprot id: G4VS33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

6183:Smp 094390
gene id: 6183:Smp_094390
uniprot id: G4VDQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

6183:Smp 068280
gene id: 6183:Smp_068280
uniprot id: G4VTC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

6183:Smp 104000.1
gene id: 6183:Smp_104000.1
uniprot id: G4VAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane

6183:Smp 063250.1
gene id: 6183:Smp_063250.1
uniprot id: G4VF91
names: Similarity
messages: Belongs to the CBP3 family.

6183:Smp 075210.1
gene id: 6183:Smp_075210.1
uniprot id: G4VS58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

6183:Smp 090920.1
gene id: 6183:Smp_090920.1
uniprot id: G4V8K8
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

6183:Smp 035580
gene id: 6183:Smp_035580
uniprot id: G4V7P4
names: Similarity
messages: Belongs to the PPP phosphatase family.

6183:Smp 102840.1
gene id: 6183:Smp_102840.1
uniprot id: G4VSZ7
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

6183:Smp 019880
gene id: 6183:Smp_019880
uniprot id: G4V8G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

6183:Smp 074070.1
gene id: 6183:Smp_074070.1
uniprot id: G4VGJ3
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 033040
gene id: 6183:Smp_033040
uniprot id: G4VRF8
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

6183:Smp 003000
gene id: 6183:Smp_003000
uniprot id: G4VJ86
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 007970
gene id: 6183:Smp_007970
uniprot id: G4VJ59
names: Similarity
messages: Belongs to the SDO1/SBDS family.

6183:Smp 045510
gene id: 6183:Smp_045510
uniprot id: Q2VU48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

6183:Smp 123000.1
gene id: 6183:Smp_123000.1
uniprot id: G4VCH5
names: Similarity
messages: Belongs to the SKI family.

6183:Smp 164100
gene id: 6183:Smp_164100
uniprot id: G4VL69
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6183:Smp 024850
gene id: 6183:Smp_024850
uniprot id: G4VMA5
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

6183:Smp 007960
gene id: 6183:Smp_007960
uniprot id: G4VJ60
names: Similarity
messages: Belongs to the 4HPPD family.

6183:Smp 094760
gene id: 6183:Smp_094760
uniprot id: G4VTU1
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 096780.1
gene id: 6183:Smp_096780.1
uniprot id: G4VJD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

6183:Smp 181000
gene id: 6183:Smp_181000
uniprot id: G4VDY7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

6183:Smp 048660
gene id: 6183:Smp_048660
uniprot id: G4VSA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

6183:Smp 026190
gene id: 6183:Smp_026190
uniprot id: G4VJW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

6183:Smp 090690
gene id: 6183:Smp_090690
uniprot id: G4VJ82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

6183:Smp 034840.1
gene id: 6183:Smp_034840.1
uniprot id: Q9U491
names: Similarity
messages: Belongs to the 14-3-3 family.

6183:Smp 141610
gene id: 6183:Smp_141610
uniprot id: Q95PM1
names: Similarity
messages: Belongs to the peptidase C1 family.

6183:Smp 012070
gene id: 6183:Smp_012070
uniprot id: G4VS07
names: Similarity
messages: Belongs to the RRP15 family.

6183:Smp 154530
gene id: 6183:Smp_154530
uniprot id: G4VJX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

6183:Smp 060090.1
gene id: 6183:Smp_060090.1
uniprot id: G4VAJ9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

6183:Smp 052910
gene id: 6183:Smp_052910
uniprot id: G4VGF4
names: Similarity
messages: Belongs to the SKP1 family.

6183:Smp 027450
gene id: 6183:Smp_027450
uniprot id: G4VIB7
names: Similarity
messages: Belongs to the misato family.

6183:Smp 012380
gene id: 6183:Smp_012380
uniprot id: G4VC52
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

6183:Smp 070200
gene id: 6183:Smp_070200
uniprot id: G4VJB4
names: Similarity
messages: Belongs to the splicing factor SR family.

6183:Smp 126370
gene id: 6183:Smp_126370
uniprot id: G4VPW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

6183:Smp 151410
gene id: 6183:Smp_151410
uniprot id: G4V7T7
names: Similarity
messages: Belongs to the PPP phosphatase family.

6183:Smp 004600
gene id: 6183:Smp_004600
uniprot id: G4VHD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

6183:Smp 129340
gene id: 6183:Smp_129340
uniprot id: C4Q0P6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.
messages: centrosome
messages: cytoskeleton

6183:Smp 077790
gene id: 6183:Smp_077790
uniprot id: G4VL73
names: Similarity
names: Subunit
messages: Belongs to the histone H2B family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 168400
gene id: 6183:Smp_168400
uniprot id: G4V7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

6183:Smp 048970.1
gene id: 6183:Smp_048970.1
uniprot id: G4VC00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 044250
gene id: 6183:Smp_044250
uniprot id: G4VEI6
names: Similarity
messages: Belongs to the peptidase M67C family.

6183:Smp 052460
gene id: 6183:Smp_052460
uniprot id: G4VHP1
names: Similarity
messages: Belongs to the cullin family.

6183:Smp 073340
gene id: 6183:Smp_073340
uniprot id: G4VAB5
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 008770
gene id: 6183:Smp_008770
uniprot id: G4VII4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

6183:Smp 132210
gene id: 6183:Smp_132210
uniprot id: G4VGQ1
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 010400
gene id: 6183:Smp_010400
uniprot id: G4VML9
names: Function
names: Similarity
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.

6183:Smp 141290.1
gene id: 6183:Smp_141290.1
uniprot id: G4V7R2
uniprot id: G4V7R3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6183:Smp 174950
gene id: 6183:Smp_174950
uniprot id: G4VR71
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

6183:Smp 086830
gene id: 6183:Smp_086830
uniprot id: G4V8L7
names: Similarity
messages: Belongs to the band 7/mec-2 family.

6183:Smp 073070
gene id: 6183:Smp_073070
uniprot id: G4VA64
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6183:Smp 160830
gene id: 6183:Smp_160830
uniprot id: G4VFV5
names: Similarity
messages: Belongs to the phospholipase D family.

6183:Smp 077090
gene id: 6183:Smp_077090
uniprot id: G4VTX8
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

6183:Smp 024030
gene id: 6183:Smp_024030
uniprot id: G4VQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

6183:Smp 099690
gene id: 6183:Smp_099690
uniprot id: G4VBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

6183:Smp 079730
gene id: 6183:Smp_079730
uniprot id: G4VFB6
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 087860
gene id: 6183:Smp_087860
uniprot id: G4VLR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

6183:Smp 031220
gene id: 6183:Smp_031220
uniprot id: G4VPL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

6183:Smp 075040
gene id: 6183:Smp_075040
uniprot id: G4VH08
names: Similarity
messages: Belongs to the UPF0538 family.

6183:KEF69 p09
gene id: 6183:KEF69_p09
uniprot id: Q9B8X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane

6183:Smp 035790
gene id: 6183:Smp_035790
uniprot id: G4VMB5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

6183:Smp 063300
gene id: 6183:Smp_063300
uniprot id: Q15ET2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

6183:Smp 040970.1
gene id: 6183:Smp_040970.1
uniprot id: G4V7J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

6183:Smp 089290
gene id: 6183:Smp_089290
uniprot id: G4VLE3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

6183:Smp 065150
gene id: 6183:Smp_065150
uniprot id: G4VCR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Nucleus

6183:Smp 027040
gene id: 6183:Smp_027040
uniprot id: G4VG01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

6183:Smp 157160
gene id: 6183:Smp_157160
uniprot id: G4VPU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

6183:Smp 075280.1
gene id: 6183:Smp_075280.1
uniprot id: G4VS68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

6183:Smp 143060
gene id: 6183:Smp_143060
uniprot id: G4VTG6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

6183:Smp 088650
gene id: 6183:Smp_088650
uniprot id: G4VDJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

6183:Smp 004680
gene id: 6183:Smp_004680
uniprot id: G4VD50
names: Similarity
messages: Belongs to the IFRD family.

6183:Smp 015860
gene id: 6183:Smp_015860
uniprot id: G4VSN6
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

6183:Smp 121920
gene id: 6183:Smp_121920
uniprot id: G4VGD1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 049390
gene id: 6183:Smp_049390
uniprot id: G4V8Z5
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

6183:Smp 134510
gene id: 6183:Smp_134510
uniprot id: G4VN13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Mitochondrion

6183:Smp 150540
gene id: 6183:Smp_150540
uniprot id: G4VK04
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 027250
gene id: 6183:Smp_027250
uniprot id: G4VHC2
names: Similarity
messages: Belongs to the SMAP family.

6183:Smp 183710
gene id: 6183:Smp_183710
uniprot id: G4VLW1
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

6183:Smp 055310
gene id: 6183:Smp_055310
uniprot id: G4V5N4
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

6183:Smp 152220
gene id: 6183:Smp_152220
uniprot id: G4V5X9
names: Similarity
messages: Belongs to the DeSI family.

6183:Smp 027400
gene id: 6183:Smp_027400
uniprot id: G4VHA4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

6183:Smp 038080.1
gene id: 6183:Smp_038080.1
uniprot id: G4VHN1
names: Subcellular Location Annotation
messages: Cytoplasm

6183:Smp 001830.1
gene id: 6183:Smp_001830.1
uniprot id: G4VLF6
uniprot id: G4VLF7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

6183:Smp 016780
gene id: 6183:Smp_016780
uniprot id: G4VKY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6183:Smp 071380.2
gene id: 6183:Smp_071380.2
uniprot id: G4VFW7
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 160670
gene id: 6183:Smp_160670
uniprot id: G4VJ65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

6183:Smp 029750
gene id: 6183:Smp_029750
uniprot id: G4VFH7
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

6183:Smp 044750
gene id: 6183:Smp_044750
uniprot id: G4VK94
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 027240
gene id: 6183:Smp_027240
uniprot id: G4VHC3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS18 family.

6183:Smp 063350
gene id: 6183:Smp_063350
uniprot id: G4VF81
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

6183:Smp 071610
gene id: 6183:Smp_071610
uniprot id: G4VRT6
names: Similarity
messages: Belongs to the peptidase S28 family.

6183:Smp 024140.1
gene id: 6183:Smp_024140.1
uniprot id: G4VQ61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

6183:Smp 028670.1
gene id: 6183:Smp_028670.1
uniprot id: G4VP62
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

6183:Smp 024880
gene id: 6183:Smp_024880
uniprot id: G4VMA1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

6183:Smp 128120
gene id: 6183:Smp_128120
uniprot id: G4VD97
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 002870
gene id: 6183:Smp_002870
uniprot id: G4VLJ1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 030870
gene id: 6183:Smp_030870
uniprot id: G4VLT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 198520
gene id: 6183:Smp_198520
uniprot id: G4VS25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF8 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 164380
gene id: 6183:Smp_164380
uniprot id: G4VLY7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

6183:Smp 060070
gene id: 6183:Smp_060070
uniprot id: G4VAK1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

6183:Smp 102410
gene id: 6183:Smp_102410
uniprot id: G4VBF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

6183:Smp 057020
gene id: 6183:Smp_057020
uniprot id: G4V5I9
names: Similarity
messages: Belongs to the DEAD box helicase family.

6183:Smp 071000
gene id: 6183:Smp_071000
uniprot id: G4VJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

6183:Smp 067280
gene id: 6183:Smp_067280
uniprot id: G4V9Q0
names: Subcellular Location Annotation
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

6183:Smp 083780
gene id: 6183:Smp_083780
uniprot id: G4V6U2
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 210270
gene id: 6183:Smp_210270
uniprot id: G4VHA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.

6183:Smp 038680
gene id: 6183:Smp_038680
uniprot id: G4VI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

6183:Smp 055990
gene id: 6183:Smp_055990
uniprot id: C4QCD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

6183:Smp 071020
gene id: 6183:Smp_071020
uniprot id: G4V7X1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

6183:Smp 016250.1
gene id: 6183:Smp_016250.1
uniprot id: G4VHF0
names: Subunit
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

6183:Smp 018990
gene id: 6183:Smp_018990
uniprot id: G4VG38
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

6183:Smp 037930
gene id: 6183:Smp_037930
uniprot id: G4VQY8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

6183:Smp 132850.1
gene id: 6183:Smp_132850.1
uniprot id: G4VTW0
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

6183:Smp 000740.1
gene id: 6183:Smp_000740.1
uniprot id: O17453
uniprot id: Q547D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S5A family.
messages: Binds and presumably selects ubiquitin-conjugates for destruction.
messages: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).

6183:Smp 046160
gene id: 6183:Smp_046160
uniprot id: G4VPT3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

6183:Smp 038240
gene id: 6183:Smp_038240
uniprot id: G4VNT2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer.

6183:Smp 144030
gene id: 6183:Smp_144030
uniprot id: G4VKI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

6183:Smp 049150
gene id: 6183:Smp_049150
uniprot id: G4VC15
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

6183:Smp 029060
gene id: 6183:Smp_029060
uniprot id: G4VGT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

6183:Smp 019060
gene id: 6183:Smp_019060
uniprot id: G4VG47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

6183:Smp 091640
gene id: 6183:Smp_091640
uniprot id: G4VLN8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

6183:Smp 196480
gene id: 6183:Smp_196480
uniprot id: G4VAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

6183:Smp 103790
gene id: 6183:Smp_103790
uniprot id: G4V865
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

6183:Smp 132020
gene id: 6183:Smp_132020
uniprot id: G4VNY6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

6183:Smp 043340
gene id: 6183:Smp_043340
uniprot id: G4VIY8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6183:Smp 126730
gene id: 6183:Smp_126730
uniprot id: G4V5G4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6183:Smp 134790
gene id: 6183:Smp_134790
uniprot id: G4VFR3
names: Similarity
names: Subunit
messages: Belongs to the TAF11 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 210750
gene id: 6183:Smp_210750
uniprot id: G4V8N4
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.

6183:Smp 142640
gene id: 6183:Smp_142640
uniprot id: G4V655
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 064350
gene id: 6183:Smp_064350
uniprot id: G4VKD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

6183:Smp 147120
gene id: 6183:Smp_147120
uniprot id: G4VLV7
names: Similarity
messages: Belongs to the DDRGK1 family.

6183:Smp 076740
gene id: 6183:Smp_076740
uniprot id: G4VGR1
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

6183:Smp 073080.1
gene id: 6183:Smp_073080.1
uniprot id: G4VA66
names: Similarity
messages: Belongs to the PNO1 family.

6183:Smp 042090.1
gene id: 6183:Smp_042090.1
uniprot id: G4VJT2
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

6183:Smp 049330
gene id: 6183:Smp_049330
uniprot id: G4V8Y9
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 041760
gene id: 6183:Smp_041760
uniprot id: G4VJQ0
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 052390
gene id: 6183:Smp_052390
uniprot id: G4VF05
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 095190
gene id: 6183:Smp_095190
uniprot id: G4VRL9
names: Similarity
messages: Belongs to the Bcl-2 family.

6183:Smp 098840
gene id: 6183:Smp_098840
uniprot id: G4V683
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

6183:Smp 060170
gene id: 6183:Smp_060170
uniprot id: G4VQN0
names: Similarity
messages: Belongs to the WD repeat rae1 family.

6183:Smp 011120
gene id: 6183:Smp_011120
uniprot id: G4VD99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

6183:Smp 151690
gene id: 6183:Smp_151690
uniprot id: G4VND5
names: Similarity
messages: Belongs to the RutC family.

6183:Smp 130980
gene id: 6183:Smp_130980
uniprot id: G4V5F8
names: Similarity
messages: Belongs to the cyclin family.

6183:Smp 062890
gene id: 6183:Smp_062890
uniprot id: G4VHU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane

6183:Smp 064860
gene id: 6183:Smp_064860
uniprot id: G4VPU9
names: Subcellular Location Annotation
messages: Cytoplasm

6183:Smp 140560
gene id: 6183:Smp_140560
uniprot id: G4V9U1
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 059930
gene id: 6183:Smp_059930
uniprot id: G4VT15
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

6183:Smp 083180.1
gene id: 6183:Smp_083180.1
uniprot id: G4V7F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

6183:Smp 046100
gene id: 6183:Smp_046100
uniprot id: G4VPS8
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.

6183:Smp 047060
gene id: 6183:Smp_047060
uniprot id: G4VNA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

6183:Smp 166980
gene id: 6183:Smp_166980
uniprot id: G4VC88
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TAF9 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 140510
gene id: 6183:Smp_140510
uniprot id: G4V9S9
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 083200.1
gene id: 6183:Smp_083200.1
uniprot id: G4V7F4
names: Similarity
messages: Belongs to the peptidase C12 family.

6183:Smp 006740
gene id: 6183:Smp_006740
uniprot id: G4V9U9
names: Subcellular Location Annotation
messages: Cytoplasm

6183:Smp 029040
gene id: 6183:Smp_029040
uniprot id: G4VGT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane

6183:Smp 060910
gene id: 6183:Smp_060910
uniprot id: G4VBP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

6183:Smp 003300
gene id: 6183:Smp_003300
uniprot id: G4V6W4
names: Similarity
messages: Belongs to the serpin family.

6183:Smp 021330.1
gene id: 6183:Smp_021330.1
uniprot id: G4V8H4
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

6183:Smp 103810.1
gene id: 6183:Smp_103810.1
uniprot id: G4VCQ2
names: Subcellular Location Annotation
messages: Cytoplasm

6183:Smp 046020
gene id: 6183:Smp_046020
uniprot id: G4VPR7
names: Similarity
messages: Belongs to the SDS22 family.

6183:Smp 071390
gene id: 6183:Smp_071390
uniprot id: G4V9S0
names: Similarity
messages: Belongs to the adenylate kinase family.

6183:Smp 012860
gene id: 6183:Smp_012860
uniprot id: G4V9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

6183:Smp 033950.1
gene id: 6183:Smp_033950.1
uniprot id: Q6UEH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 061920.1
gene id: 6183:Smp_061920.1
uniprot id: A9CBJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

6183:Smp 087820
gene id: 6183:Smp_087820
uniprot id: G4VLQ6
names: Similarity
messages: Belongs to the cornifelin family.

6183:Smp 034010
gene id: 6183:Smp_034010
uniprot id: G4V9T7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

6183:Smp 099420
gene id: 6183:Smp_099420
uniprot id: G4VLQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 033400
gene id: 6183:Smp_033400
uniprot id: Q15EU2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

6183:Smp 172850
gene id: 6183:Smp_172850
uniprot id: G4V5E8
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

6183:Smp 046290
gene id: 6183:Smp_046290
uniprot id: G4VKT0
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 118220
gene id: 6183:Smp_118220
uniprot id: G4V772
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 063640
gene id: 6183:Smp_063640
uniprot id: G4VA12
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

6183:Smp 097210
gene id: 6183:Smp_097210
uniprot id: G4VD04
names: Subcellular Location Annotation
messages: nuclear pore complex

6183:Smp 092380
gene id: 6183:Smp_092380
uniprot id: G4VHY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

6183:Smp 032310
gene id: 6183:Smp_032310
uniprot id: G4VSI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

6183:Smp 054310
gene id: 6183:Smp_054310
uniprot id: G4VQK6
names: Similarity
messages: Belongs to the peptidase M50A family.

6183:Smp 137590
gene id: 6183:Smp_137590
uniprot id: G4VP71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

6183:Smp 071560
gene id: 6183:Smp_071560
uniprot id: G4V9J3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 020220.1
gene id: 6183:Smp_020220.1
uniprot id: G4V8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

6183:Smp 039970
gene id: 6183:Smp_039970
uniprot id: G4VKG8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

6183:Smp 066760.1
gene id: 6183:Smp_066760.1
uniprot id: G4VND1
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

6183:Smp 072180
gene id: 6183:Smp_072180
uniprot id: G4V9D2
names: Similarity
messages: Belongs to the Bcl-2 family.

6183:Smp 086760
gene id: 6183:Smp_086760
uniprot id: G4VKL5
names: Similarity
messages: Belongs to the phosducin family.

6183:Smp 145360.1
gene id: 6183:Smp_145360.1
uniprot id: G4VIU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

6183:Smp 154690
gene id: 6183:Smp_154690
uniprot id: G4V6H6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

6183:Smp 153890.1
gene id: 6183:Smp_153890.1
uniprot id: G4VJ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP2 family.
messages: Membrane

6183:Smp 025510
gene id: 6183:Smp_025510
uniprot id: G4VPD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

6183:Smp 012540
gene id: 6183:Smp_012540
uniprot id: G4V975
names: Subcellular Location Annotation
messages: nucleolus

6183:Smp 096750
gene id: 6183:Smp_096750
uniprot id: G4VJD7
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

6183:Smp 056620
gene id: 6183:Smp_056620
uniprot id: G4VH55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

6183:Smp 074930
gene id: 6183:Smp_074930
uniprot id: G4VH15
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

6183:Smp 022090
gene id: 6183:Smp_022090
uniprot id: G4VE33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

6183:Smp 135100
gene id: 6183:Smp_135100
uniprot id: G4VD20
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

6183:Smp 073410
gene id: 6183:Smp_073410
uniprot id: G4VSW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

6183:Smp 074150.1
gene id: 6183:Smp_074150.1
uniprot id: C4QH88
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6183:Smp 168770
gene id: 6183:Smp_168770
uniprot id: G4VF32
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

6183:Smp 054330
gene id: 6183:Smp_054330
uniprot id: G4VQK3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

6183:Smp 042400
gene id: 6183:Smp_042400
uniprot id: G4VJE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

6183:Smp 005740
gene id: 6183:Smp_005740
uniprot id: C4PYI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

6183:Smp 179130
gene id: 6183:Smp_179130
uniprot id: G4VJX3
names: Similarity
messages: Belongs to the SMIM12 family.

6183:Smp 067780
gene id: 6183:Smp_067780
uniprot id: G4VHW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

6183:Smp 061570
gene id: 6183:Smp_061570
uniprot id: G4VKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 053300
gene id: 6183:Smp_053300
uniprot id: C4QBN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 043990.1
gene id: 6183:Smp_043990.1
uniprot id: G4VD39
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Lateral cell membrane

6183:Smp 158430
gene id: 6183:Smp_158430
uniprot id: G4V5B9
names: Similarity
messages: Belongs to the RNase T2 family.

6183:Smp 065890
gene id: 6183:Smp_065890
uniprot id: G4VPA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

6183:Smp 126310
gene id: 6183:Smp_126310
uniprot id: G4VPX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

6183:Smp 023660
gene id: 6183:Smp_023660
uniprot id: G4VFT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

6183:Smp 037910
gene id: 6183:Smp_037910
uniprot id: G4V6D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

6183:Smp 027010.1
gene id: 6183:Smp_027010.1
uniprot id: G4VFZ8
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

6183:Smp 093440
gene id: 6183:Smp_093440
uniprot id: G4V605
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

6183:Smp 153790
gene id: 6183:Smp_153790
uniprot id: G4VJ35
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

6183:Smp 021760
gene id: 6183:Smp_021760
uniprot id: G4VDU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

6183:Smp 073560.1
gene id: 6183:Smp_073560.1
uniprot id: G4V788
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of TORC1 complex. Part of the TORC2 complex.
messages: Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.

6183:Smp 103610
gene id: 6183:Smp_103610
uniprot id: Q8MNY2
names: Similarity
messages: Belongs to the peptidase C1 family.

6183:Smp 005230.1
gene id: 6183:Smp_005230.1
uniprot id: G4V611
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

6183:Smp 059480
gene id: 6183:Smp_059480
uniprot id: G4VKD9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

6183:Smp 118040
gene id: 6183:Smp_118040
uniprot id: G4V636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

6183:Smp 082860
gene id: 6183:Smp_082860
uniprot id: G4VC69
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

6183:Smp 030930.1
gene id: 6183:Smp_030930.1
uniprot id: G4VLU1
uniprot id: G4VLU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

6183:Smp 033020
gene id: 6183:Smp_033020
uniprot id: G4VR92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

6183:Smp 013060
gene id: 6183:Smp_013060
uniprot id: Q9GQN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 080730
gene id: 6183:Smp_080730
uniprot id: G4VLX9
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 005210
gene id: 6183:Smp_005210
uniprot id: G4V604
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

6183:Smp 066940
gene id: 6183:Smp_066940
uniprot id: G4VIK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

6183:Smp 010100
gene id: 6183:Smp_010100
uniprot id: C4PZQ3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

6183:Smp 013040.1
gene id: 6183:Smp_013040.1
uniprot id: G4VEV6
names: Similarity
messages: Belongs to the peptidase A1 family.

6183:Smp 040020
gene id: 6183:Smp_040020
uniprot id: G4VKH6
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 086190
gene id: 6183:Smp_086190
uniprot id: G4VCE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

6183:Smp 099900
gene id: 6183:Smp_099900
uniprot id: G4VAD0
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

6183:Smp 129080
gene id: 6183:Smp_129080
uniprot id: G4V9I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

6183:Smp 006850
gene id: 6183:Smp_006850
uniprot id: G4V892
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

6183:Smp 015850.2
gene id: 6183:Smp_015850.2
uniprot id: G4VSN5
names: Similarity
messages: Belongs to the Luc7 family.

6183:Smp 001640
gene id: 6183:Smp_001640
uniprot id: G4VCG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

6183:Smp 061870
gene id: 6183:Smp_061870
uniprot id: G4VNI0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

6183:Smp 020080.1
gene id: 6183:Smp_020080.1
uniprot id: G4V8F7
names: Subunit
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

6183:Smp 032800.1
gene id: 6183:Smp_032800.1
uniprot id: G4VDI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

6183:Smp 066900
gene id: 6183:Smp_066900
uniprot id: G4VIL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions.
messages: gap junction

6183:Smp 046980
gene id: 6183:Smp_046980
uniprot id: G4VNB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

6183:Smp 210290
gene id: 6183:Smp_210290
uniprot id: G4VJK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Membrane

6183:Smp 210500
gene id: 6183:Smp_210500
uniprot id: B4XC67
names: Similarity
messages: Belongs to the peptidase C1 family.

6183:Smp 040560
gene id: 6183:Smp_040560
uniprot id: G4VB67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

6183:Smp 102070
gene id: 6183:Smp_102070
uniprot id: P35661
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
messages: Homodimer.

6183:Smp 075110
gene id: 6183:Smp_075110
uniprot id: G4VH02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

6183:Smp 079430.1
gene id: 6183:Smp_079430.1
uniprot id: G4V793
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

6183:Smp 148540
gene id: 6183:Smp_148540
uniprot id: G4V8Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

6183:Smp 059540
gene id: 6183:Smp_059540
uniprot id: G4VKV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits.

6183:Smp 053510.1
gene id: 6183:Smp_053510.1
uniprot id: G4VJ11
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

6183:Smp 091010
gene id: 6183:Smp_091010
uniprot id: G4VRK1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

6183:Smp 049000
gene id: 6183:Smp_049000
uniprot id: G4VC03
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 016730
gene id: 6183:Smp_016730
uniprot id: G4VKX8
names: Similarity
messages: Belongs to the HEBP family.

6183:Smp 122920
gene id: 6183:Smp_122920
uniprot id: G4VCG2
names: Subcellular Location Annotation
messages: Nucleus

6183:Smp 103710
gene id: 6183:Smp_103710
uniprot id: G4VRA7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

6183:Smp 048430
gene id: 6183:Smp_048430
uniprot id: Q962Y6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

6183:Smp 025010
gene id: 6183:Smp_025010
uniprot id: G4VM90
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Tetramer of two alpha and two beta subunits.

6183:Smp 009550
gene id: 6183:Smp_009550
uniprot id: G4V9Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

6183:Smp 194170
gene id: 6183:Smp_194170
uniprot id: G4V672
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

6183:Smp 058240
gene id: 6183:Smp_058240
uniprot id: G4VNM5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 212320
gene id: 6183:Smp_212320
uniprot id: G4VLI9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

6183:Smp 064510
gene id: 6183:Smp_064510
uniprot id: G4VKB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

6183:Smp 001590.1
gene id: 6183:Smp_001590.1
uniprot id: G4VCG3
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

6183:Smp 077590
gene id: 6183:Smp_077590
uniprot id: G4VL53
names: Similarity
messages: Belongs to the CWC26 family.

6183:Smp 143460
gene id: 6183:Smp_143460
uniprot id: G4VDE7
names: Similarity
messages: Belongs to the SAPAP family.

6183:Smp 045500
gene id: 6183:Smp_045500
uniprot id: G4VI66
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

6183:Smp 088460
gene id: 6183:Smp_088460
uniprot id: G4V8A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

6183:Smp 007000
gene id: 6183:Smp_007000
uniprot id: G4VDF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

6183:Smp 013460
gene id: 6183:Smp_013460
uniprot id: G4VH48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

6183:Smp 015980
gene id: 6183:Smp_015980
uniprot id: G4VJN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

6183:Smp 079560
gene id: 6183:Smp_079560
uniprot id: G4V7V1
names: Similarity
messages: Belongs to the MCM family.

6183:Smp 018210
gene id: 6183:Smp_018210
uniprot id: G4VP16
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 048870
gene id: 6183:Smp_048870
uniprot id: G4VBZ2
names: Similarity
messages: Belongs to the CutA family.

6183:Smp 124240
gene id: 6183:Smp_124240
uniprot id: C4PY08
names: Similarity
messages: Belongs to the X(+)/potassium ATPases subunit beta family.

6183:Smp 059980
gene id: 6183:Smp_059980
uniprot id: Q6WVP6
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

6183:Smp 174130
gene id: 6183:Smp_174130
uniprot id: G4VTT7
names: Subcellular Location Annotation
messages: Membrane

6183:Smp 060270
gene id: 6183:Smp_060270
uniprot id: G4VQM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

6183:Smp 170450
gene id: 6183:Smp_170450
uniprot id: G4VDQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

6183:Smp 128610
gene id: 6183:Smp_128610
uniprot id: G4VS06
names: Similarity
messages: Belongs to the cytochrome c oxidase IV family.

6183:Smp 021140
gene id: 6183:Smp_021140
uniprot id: G4VDK2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

6183:Smp 136730
gene id: 6183:Smp_136730
uniprot id: G4VFY7
names: Similarity
messages: Belongs to the peptidase A1 family.

6183:Smp 097380
gene id: 6183:Smp_097380
uniprot id: G4VML2
names: Similarity
messages: Belongs to the GroES chaperonin family.

6183:Smp 022320.1
gene id: 6183:Smp_022320.1
uniprot id: G4VPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 006680
gene id: 6183:Smp_006680
uniprot id: G4V9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cytoplasm

6183:Smp 083120
gene id: 6183:Smp_083120
uniprot id: G4V7E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

6183:Smp 103100
gene id: 6183:Smp_103100
uniprot id: G4VTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

6183:Smp 036130
gene id: 6183:Smp_036130
uniprot id: G4VHU3
names: Similarity
messages: Belongs to the phosducin family.

6183:Smp 050830
gene id: 6183:Smp_050830
uniprot id: G4VIB3
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

6183:Smp 099030
gene id: 6183:Smp_099030
uniprot id: G4VR11
names: Similarity
messages: Belongs to the protein kinase superfamily.

6183:Smp 122490
gene id: 6183:Smp_122490
uniprot id: G4V665
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

6183:Smp 003440
gene id: 6183:Smp_003440
uniprot id: G4V6P0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

6183:Smp 094480
gene id: 6183:Smp_094480
uniprot id: G4VTR5
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

6183:Smp 079810
gene id: 6183:Smp_079810
uniprot id: G4VFC5
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

6183:Smp 053800
gene id: 6183:Smp_053800
uniprot id: G4VHS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 105370
gene id: 6183:Smp_105370
uniprot id: G4V5E2
names: Similarity
messages: Belongs to the peptidase C1 family.

6183:Smp 129160
gene id: 6183:Smp_129160
uniprot id: G4VEV8
names: Similarity
messages: Belongs to the NRDE2 family.

6183:Smp 058130.1
gene id: 6183:Smp_058130.1
uniprot id: G4VK41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 015900
gene id: 6183:Smp_015900
uniprot id: G4VJP1
names: Similarity
messages: Belongs to the Iojap/RsfS family.

6183:Smp 084460
gene id: 6183:Smp_084460
uniprot id: G4VSC8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

6183:Smp 053610
gene id: 6183:Smp_053610
uniprot id: G4VIZ9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

6183:Smp 069770
gene id: 6183:Smp_069770
uniprot id: G4VK53
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

6183:Smp 080420
gene id: 6183:Smp_080420
uniprot id: G4VTP8
names: Similarity
messages: Belongs to the bZIP family. Jun subfamily.

6183:Smp 064870
gene id: 6183:Smp_064870
uniprot id: G4VPU8
names: Similarity
messages: Belongs to the dynein intermediate chain family.

6183:Smp 163840
gene id: 6183:Smp_163840
uniprot id: G4VTM0
names: Similarity
messages: Belongs to the TPRG1 family.

6183:Smp 089860
gene id: 6183:Smp_089860
uniprot id: C4QHD7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 159490
gene id: 6183:Smp_159490
uniprot id: G4VQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

6183:Smp 043290
gene id: 6183:Smp_043290
uniprot id: C4Q8W8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

6183:Smp 054540
gene id: 6183:Smp_054540
uniprot id: G4VQH7
names: Similarity
messages: Belongs to the MAPRE family.

6183:Smp 026880
gene id: 6183:Smp_026880
uniprot id: G4VFY4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

6183:Smp 095130
gene id: 6183:Smp_095130
uniprot id: G4VRL5
names: Similarity
messages: Belongs to the HMBS family.

6183:Smp 018610
gene id: 6183:Smp_018610
uniprot id: G4VGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 169690
gene id: 6183:Smp_169690
uniprot id: G4VG55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

6183:Smp 174510
gene id: 6183:Smp_174510
uniprot id: G4V850
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6183:Smp 031310
gene id: 6183:Smp_031310
uniprot id: G4VPM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

6183:Smp 124230
gene id: 6183:Smp_124230
uniprot id: G4V6K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.
messages: Nucleus

6183:Smp 029890
gene id: 6183:Smp_029890
uniprot id: A0A3Q0KDV9
names: Cofactor
names: Developmental Stage
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: C-terminus (307-412) is necessary for binding to liposomal membranes as assessed by phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), models of biological membranes.
messages: Expressed throughout the developmental cycle of the schistosome, with the highest expression in 14-day old schistosomula. Expressed in superficial structures of the miracidia and sporocysts, with high expression in ciliated epidermal plates of the miracidium, and in the longitudinal and circular muscles of the sporocyst. High expression also in the optical sections of germ cells in miracidia and 2-day old sporocysts. Expressed along the protonephridial ducts of the cercaria, extending laterally nearly the whole length on both sides of the larva. More specifically expressed at the collecting tubules of this osmoregulatory system. Expressed ubiquitously in the schistosomulum. In adults, expression is higher in males than in females.
messages: Filament-forming GTP-binding protein. Lacks GTPase activity, which is likely due to absence of an essential threonine residue important for hydrolytic activity in septins. May be involved in membrane remodeling, potentially by its nucleotide-dependent cellular membrane association/dissociation ability (PubMed:24464615). Able to bind to phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes. Self-assembles into ordered cage-like structures on the vesicle membrane. Binds also to 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS)-containing vesicles suggesting the requirement for negatively charged membranes. Is also able to promote deformation of the GUVs (PubMed:27687162).
messages: Mg(2+) is essential for the GTP-binding, but GDP-binding does not require a metal cofactor.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules (By similarity). Homodimer (PubMed:27687162, PubMed:24464615). Homooligomerizes (PubMed:27687162). Forms (via GTP-binding domain) heterodimers with SEPT5 (via GTP-binding domain) in a nucleotide-dependent manner with GTP promoting heterodimerization most efficiently (PubMed:27687162). Component of the filamentous forming heterocomplex composed of SEPT10, SEPT5 and SEPT7.2 (PubMed:24768753, PubMed:27687162). Heterocomplex formation and the filamentous polymerization of the complexes is enhanced by forchlorfenuron (FCF), a synthetic phenylurea cytokinin (PubMed:24768753). The heterocomplex is able to bind on the membranes of the phosphatidylinositol-4,5-bisphosphate (PIP2)-containing giant unilamellar vesicles (GUVs), which serve as a model of biological membranes (PubMed:27687162).
messages: cytoskeleton

6183:Smp 008120
gene id: 6183:Smp_008120
uniprot id: G4V7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

6183:Smp 151030
gene id: 6183:Smp_151030
uniprot id: G4VHQ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

6183:Smp 063580.1
gene id: 6183:Smp_063580.1
uniprot id: G4VA08
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

6183:Smp 074780
gene id: 6183:Smp_074780
uniprot id: G4VH28
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

6183:Smp 044690
gene id: 6183:Smp_044690
uniprot id: G4VK90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

6183:Smp 015800
gene id: 6183:Smp_015800
uniprot id: G4VSM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

6183:Smp 053820
gene id: 6183:Smp_053820
uniprot id: G4VHS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

6183:Smp 030220
gene id: 6183:Smp_030220
uniprot id: A0A7S9YVD6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

6183:Smp 035430.1
gene id: 6183:Smp_035430.1
uniprot id: G4V7Y4
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

6183:Smp 126690
gene id: 6183:Smp_126690
uniprot id: G4V7G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

6183:Smp 046630
gene id: 6183:Smp_046630
uniprot id: G4VLW5
names: Subcellular Location Annotation
messages: Secreted

6183:Smp 070030
gene id: 6183:Smp_070030
uniprot id: G4VJC7
names: Similarity
messages: Belongs to the SNF7 family.

6183:Smp 004990
gene id: 6183:Smp_004990
uniprot id: G4V5L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

6183:Smp 130170
gene id: 6183:Smp_130170
uniprot id: G4VBV9
names: Similarity
messages: Belongs to the ubiquitin family.

6183:Smp 095500
gene id: 6183:Smp_095500
uniprot id: G4V851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

6183:Smp 105410
gene id: 6183:Smp_105410
uniprot id: G4VC44
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

6183:KEF69 p06
gene id: 6183:KEF69_p06
uniprot id: Q9B8X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

6183:Smp 082370
gene id: 6183:Smp_082370
uniprot id: G4VN23
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

6183:Smp 059810
gene id: 6183:Smp_059810
uniprot id: G4V9A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus