61622:SLC6A2
gene id: 61622:SLC6A2
uniprot id: A0A2K6P6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:UBN1
gene id: 61622:UBN1
uniprot id: A0A2K6PB26
uniprot id: A0A2K6PB57
names: Similarity
messages: Belongs to the ubinuclein family.

61622:TLCD4
gene id: 61622:TLCD4
uniprot id: A0A2K6RSK1
names: Subcellular Location Annotation
messages: Membrane

61622:SH3GL1
gene id: 61622:SH3GL1
uniprot id: A0A2K6QWG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
messages: Membrane

61622:PSMB4
gene id: 61622:PSMB4
uniprot id: A0A2K6P367
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

61622:DLL4
gene id: 61622:DLL4
uniprot id: A0A2K6N8K6
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

61622:PES1
gene id: 61622:PES1
uniprot id: A0A2K6NWN2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Chromosome
messages: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
messages: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: Sumoylated.
messages: nucleolus
messages: nucleoplasm

61622:AP2S1
gene id: 61622:AP2S1
uniprot id: A0A2K6RVK8
uniprot id: A0A2K6RVL6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: coated pit

61622:ILDR1
gene id: 61622:ILDR1
uniprot id: A0A2K6R7T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

61622:LCK
gene id: 61622:LCK
uniprot id: A0A2K6PA85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

61622:INTU
gene id: 61622:INTU
uniprot id: A0A2K6PGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inturned family.
messages: Cell surface
messages: cilium basal body

61622:PRLHR
gene id: 61622:PRLHR
uniprot id: A0A2K6NPT3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PLPPR5
gene id: 61622:PLPPR5
uniprot id: A0A2K6QIP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:CACNG6
gene id: 61622:CACNG6
uniprot id: A0A2K6RB03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

61622:ARF6
gene id: 61622:ARF6
uniprot id: A0A2K6NQD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

61622:PDCD4
gene id: 61622:PDCD4
uniprot id: A0A2K6RAP0
names: Similarity
messages: Belongs to the PDCD4 family.

61622:CPA1
gene id: 61622:CPA1
uniprot id: A0A2K6P7M4
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:PCYT2
gene id: 61622:PCYT2
uniprot id: A0A2K6QPH1
names: Similarity
messages: Belongs to the cytidylyltransferase family.

61622:ITGA7
gene id: 61622:ITGA7
uniprot id: A0A2K6RKM6
uniprot id: A0A2K6RKN6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SUSD4
gene id: 61622:SUSD4
uniprot id: A0A2K6PCU7
uniprot id: A0A2K6PCZ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NDUFA7
gene id: 61622:NDUFA7
uniprot id: A0A2K6R6U6
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

61622:NCAM1
gene id: 61622:NCAM1
uniprot id: A0A2K6RHN5
names: Function
messages: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

61622:FAM135A
gene id: 61622:FAM135A
uniprot id: A0A2K6RBZ2
names: Similarity
messages: Belongs to the FAM135 family.

61622:CHGA
gene id: 61622:CHGA
uniprot id: A0A2K6QWI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

61622:SUPT3H
gene id: 61622:SUPT3H
uniprot id: A0A2K6NBV1
names: Subcellular Location Annotation
messages: Nucleus

61622:SNAPC3
gene id: 61622:SNAPC3
uniprot id: A0A2K6RMS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAPC3/SRD2 family.
messages: Nucleus
messages: Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.
messages: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

61622:OTOGL
gene id: 61622:OTOGL
uniprot id: A0A2K6N9Q2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GSX1
gene id: 61622:GSX1
uniprot id: A0A2K6PIN4
names: Subcellular Location Annotation
messages: Nucleus

61622:PAPPA2
gene id: 61622:PAPPA2
uniprot id: A0A2K6QU17
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:FBXO9
gene id: 61622:FBXO9
uniprot id: A0A2K6P1K1
names: Subcellular Location Annotation
messages: Cytoplasm

61622:ZSCAN31
gene id: 61622:ZSCAN31
uniprot id: A0A2K6PFB8
names: Subcellular Location Annotation
messages: Nucleus

61622:MARCHF4
gene id: 61622:MARCHF4
uniprot id: A0A2K6R7H2
names: Subcellular Location Annotation
messages: Membrane

61622:NKX1-2
gene id: 61622:NKX1-2
uniprot id: A0A2K6QXL5
names: Subcellular Location Annotation
messages: Nucleus

61622:TGM3
gene id: 61622:TGM3
uniprot id: A0A2K6RXH7
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:PLOD3
gene id: 61622:PLOD3
uniprot id: A0A2K6QK63
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61622:OGN
gene id: 61622:OGN
uniprot id: A0A2K6P660
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

61622:SULT1E1
gene id: 61622:SULT1E1
uniprot id: A0A2K6RTK2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:LOC104674154
gene id: 61622:LOC104674154
uniprot id: A0A2K6RW35
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:KEG34 p10
gene id: 61622:KEG34_p10
uniprot id: Q15GN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:LOC104669505
gene id: 61622:LOC104669505
uniprot id: A0A2K6PDC6
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

61622:ELP5
gene id: 61622:ELP5
uniprot id: A0A2K6P4H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

61622:NEK9
gene id: 61622:NEK9
uniprot id: A0A2K6NF83
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

61622:GAPVD1
gene id: 61622:GAPVD1
uniprot id: A0A2K6PM72
uniprot id: A0A2K6PM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAPVD1 family.
messages: Membrane

61622:DERL1
gene id: 61622:DERL1
uniprot id: A0A2K6RKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

61622:ADCK2
gene id: 61622:ADCK2
uniprot id: A0A2K6RPA8
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

61622:EPO
gene id: 61622:EPO
uniprot id: A0A1L1WKB9
uniprot id: A0A2K6RUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

61622:NSUN5
gene id: 61622:NSUN5
uniprot id: A0A2K6R7E1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61622:CC2D1B
gene id: 61622:CC2D1B
uniprot id: A0A2K6NEF6
names: Similarity
messages: Belongs to the CC2D1 family.

61622:ABCC3
gene id: 61622:ABCC3
uniprot id: A0A2K6QW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:ITIH6
gene id: 61622:ITIH6
uniprot id: A0A2K6NTP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:SERPINB2
gene id: 61622:SERPINB2
uniprot id: A0A2K6QH39
names: Similarity
messages: Belongs to the serpin family.

61622:LOC104654342
gene id: 61622:LOC104654342
uniprot id: A0A2K6R3J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

61622:ADAM17
gene id: 61622:ADAM17
uniprot id: A0A2K6QKL3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CNKSR3
gene id: 61622:CNKSR3
uniprot id: A0A2K6PFA4
names: Similarity
messages: Belongs to the CNKSR family.

61622:DHPS
gene id: 61622:DHPS
uniprot id: A0A2K6QXF7
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

61622:SLC31A2
gene id: 61622:SLC31A2
uniprot id: A0A2K6PP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

61622:GIP
gene id: 61622:GIP
uniprot id: A0A2K6P2Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

61622:LOC104654375
gene id: 61622:LOC104654375
uniprot id: A0A2K6NVG6
uniprot id: A0A2K6NVG8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:HOXA7
gene id: 61622:HOXA7
uniprot id: A0A2K6PE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:TNFSF13B
gene id: 61622:TNFSF13B
uniprot id: A0A2K6QU57
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:RIDA
gene id: 61622:RIDA
uniprot id: A0A2K6QEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RutC family.
messages: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
messages: Peroxisome

61622:ZNF165
gene id: 61622:ZNF165
uniprot id: A0A2K6QBX8
names: Subcellular Location Annotation
messages: Nucleus

61622:TBP
gene id: 61622:TBP
uniprot id: A0A2K6QDE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

61622:CTC1
gene id: 61622:CTC1
uniprot id: A0A2K6NIU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

61622:ATP6AP2
gene id: 61622:ATP6AP2
uniprot id: A0A2K6PPE0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

61622:ARF3
gene id: 61622:ARF3
uniprot id: A0A2K6R8G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61622:SND1
gene id: 61622:SND1
uniprot id: A0A2K6PMW7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

61622:PITPNM1
gene id: 61622:PITPNM1
uniprot id: A0A2K6NBZ0
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

61622:LLPH
gene id: 61622:LLPH
uniprot id: A0A2K6RLY5
names: Similarity
messages: Belongs to the learning-associated protein family.

61622:LOC104674934
gene id: 61622:LOC104674934
uniprot id: A0A2K6NJS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:LOC104674192
gene id: 61622:LOC104674192
uniprot id: A0A2K6NJG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:GLB1L3
gene id: 61622:GLB1L3
uniprot id: A0A2K6RK25
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

61622:TTC27
gene id: 61622:TTC27
uniprot id: A0A2K6RT00
names: Similarity
messages: Belongs to the TTC27 family.

61622:CDH11
gene id: 61622:CDH11
uniprot id: A0A2K6PT09
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:TMEM258
gene id: 61622:TMEM258
uniprot id: A0A2K6RHS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

61622:LAMP3
gene id: 61622:LAMP3
uniprot id: A0A2K6NRS0
uniprot id: A0A2K6NRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

61622:MYF6
gene id: 61622:MYF6
uniprot id: A0A2K6QZF8
names: Subcellular Location Annotation
messages: Nucleus

61622:NDUFB10
gene id: 61622:NDUFB10
uniprot id: A0A2K6NAM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.
messages: Belongs to the complex I NDUFB10 subunit family.
messages: Mitochondrion inner membrane

61622:TMPRSS13
gene id: 61622:TMPRSS13
uniprot id: A0A2K6RVT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:BTG2
gene id: 61622:BTG2
uniprot id: A0A2K6N9H0
names: Similarity
messages: Belongs to the BTG family.

61622:ALDOC
gene id: 61622:ALDOC
uniprot id: A0A2K6QMK1
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

61622:GPBP1
gene id: 61622:GPBP1
uniprot id: A0A2K6PKS6
uniprot id: A0A2K6PL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

61622:MARVELD2
gene id: 61622:MARVELD2
uniprot id: A0A2K6PM38
uniprot id: A0A2K6PM94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

61622:ERG
gene id: 61622:ERG
uniprot id: A0A2K6QAE9
uniprot id: A0A2K6QAG2
uniprot id: A0A2K6QAG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:VPS26C
gene id: 61622:VPS26C
uniprot id: A0A2K6QSB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

61622:AKIRIN1
gene id: 61622:AKIRIN1
uniprot id: A0A2K6NI59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

61622:STX11
gene id: 61622:STX11
uniprot id: A0A2K6NN07
names: Similarity
messages: Belongs to the syntaxin family.

61622:TNFRSF19
gene id: 61622:TNFRSF19
uniprot id: A0A2K6RFT4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MBTD1
gene id: 61622:MBTD1
uniprot id: A0A2K6QRP2
names: Subcellular Location Annotation
messages: Nucleus

61622:PTGDR2
gene id: 61622:PTGDR2
uniprot id: A0A2K6NC58
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:CASR
gene id: 61622:CASR
uniprot id: A0A2K6NU62
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CNOT8
gene id: 61622:CNOT8
uniprot id: A0A2K6NXG5
uniprot id: A0A2K6NXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

61622:FAM3D
gene id: 61622:FAM3D
uniprot id: A0A2K6PP92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

61622:ACKR3
gene id: 61622:ACKR3
uniprot id: A0A2K6QF18
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:DYRK3
gene id: 61622:DYRK3
uniprot id: A0A2K6NK30
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

61622:LOC104658327
gene id: 61622:LOC104658327
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:ADSL
gene id: 61622:ADSL
uniprot id: A0A2K6P3B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

61622:ACSS2
gene id: 61622:ACSS2
uniprot id: A0A2K6P2B4
uniprot id: A0A2K6P2C4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:HMGN4
gene id: 61622:HMGN4
uniprot id: A0A2K6NNM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

61622:LOC104657860
gene id: 61622:LOC104657860
uniprot id: A0A2K6RXK3
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:NRM
gene id: 61622:NRM
uniprot id: A0A2K6PAU7
uniprot id: A0A2K6PAW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nurim family.
messages: Membrane
messages: Nucleus inner membrane

61622:FBN2
gene id: 61622:FBN2
uniprot id: A0A2K6RSL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:LOC104653692
gene id: 61622:LOC104653692
uniprot id: A0A2K6NSA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:LSR
gene id: 61622:LSR
uniprot id: A0A2K6QKQ6
uniprot id: A0A2K6QKQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

61622:PANX2
gene id: 61622:PANX2
uniprot id: A0A2K6QFK2
uniprot id: A0A2K6QFL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

61622:SNRNP200
gene id: 61622:SNRNP200
uniprot id: A0A2K6QI64
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

61622:ITGA2B
gene id: 61622:ITGA2B
uniprot id: A0A2K6R6Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:SLC19A3
gene id: 61622:SLC19A3
uniprot id: A0A2K6Q3M3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
messages: Membrane

61622:KEG34 p08
gene id: 61622:KEG34_p08
uniprot id: Q15GN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

61622:BDKRB2
gene id: 61622:BDKRB2
uniprot id: A0A2K6QVS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
messages: Membrane
messages: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

61622:GAS8
gene id: 61622:GAS8
uniprot id: A0A2K6PVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC4 family.
messages: flagellum axoneme

61622:ADAMTS9
gene id: 61622:ADAMTS9
uniprot id: A0A2K6QJG0
uniprot id: A0A2K6QJG4
uniprot id: A0A2K6QJG8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:YPEL4
gene id: 61622:YPEL4
uniprot id: A0A2K6Q1I5
names: Similarity
messages: Belongs to the yippee family.

61622:LRP12
gene id: 61622:LRP12
uniprot id: A0A2K6NP38
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104670357
gene id: 61622:LOC104670357
uniprot id: A0A2K6RFN7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Cytoplasm
messages: Homodimer.

61622:OSBPL11
gene id: 61622:OSBPL11
uniprot id: A0A2K6QNM9
names: Similarity
messages: Belongs to the OSBP family.

61622:LOC104677846
gene id: 61622:LOC104677846
uniprot id: A0A2K6R7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM231 family.
messages: Membrane
messages: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.
messages: cilium membrane

61622:SEC22A
gene id: 61622:SEC22A
uniprot id: A0A2K6NNF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

61622:PGM2L1
gene id: 61622:PGM2L1
uniprot id: A0A2K6Q0V0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

61622:NR2C1
gene id: 61622:NR2C1
uniprot id: A0A2K6RWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:TMPRSS6
gene id: 61622:TMPRSS6
uniprot id: A0A2K6RQB8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104676331
gene id: 61622:LOC104676331
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:B3GNT3
gene id: 61622:B3GNT3
uniprot id: A0A2K6PPQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:AP1B1
gene id: 61622:AP1B1
uniprot id: A0A2K6P3Y6
uniprot id: A0A2K6P3Z1
uniprot id: A0A2K6P403
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:ATP7B
gene id: 61622:ATP7B
uniprot id: A0A2K6PP59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

61622:POLR2H
gene id: 61622:POLR2H
uniprot id: A0A2K6QYF5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

61622:ARSG
gene id: 61622:ARSG
uniprot id: A0A2K6PHZ6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:ROCK1
gene id: 61622:ROCK1
uniprot id: A0A2K6RJ43
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

61622:TEKT1
gene id: 61622:TEKT1
uniprot id: A0A2K6Q076
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61622:HTR1B
gene id: 61622:HTR1B
uniprot id: A0A2K6NJ45
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
messages: Homodimer. Heterodimer with HTR1D.
messages: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
messages: Membrane
messages: Palmitoylated.
messages: Phosphorylated.

61622:SULT1B1
gene id: 61622:SULT1B1
uniprot id: A0A2K6PFP4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:SLC6A15
gene id: 61622:SLC6A15
uniprot id: A0A2K6Q496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

61622:EMC4
gene id: 61622:EMC4
uniprot id: A0A2K6NJ32
uniprot id: A0A2K6NJ49
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:BTN1A1
gene id: 61622:BTN1A1
uniprot id: A0A2K6PKV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

61622:MAP2K4
gene id: 61622:MAP2K4
uniprot id: A0A2K6PJ79
uniprot id: A0A2K6PJ85
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TRHR
gene id: 61622:TRHR
uniprot id: A0A2K6R5V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

61622:TBL1XR1
gene id: 61622:TBL1XR1
uniprot id: A0A2K6RFV8
uniprot id: A0A2K6RFZ7
names: Similarity
messages: Belongs to the WD repeat EBI family.

61622:LOC104663427
gene id: 61622:LOC104663427
uniprot id: A0A2K6NDE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

61622:NOC3L
gene id: 61622:NOC3L
uniprot id: A0A2K6NXP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: nucleolus

61622:TYR
gene id: 61622:TYR
uniprot id: A0A2K6NIW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

61622:LYZ
gene id: 61622:LYZ
uniprot id: A0A2K6PT75
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Monomer.

61622:HTATSF1
gene id: 61622:HTATSF1
uniprot id: A0A2K6NM05
names: Similarity
messages: Belongs to the HTATSF1 family.

61622:KCNH6
gene id: 61622:KCNH6
uniprot id: A0A2K6RMZ0
uniprot id: A0A2K6RMZ9
uniprot id: A0A2K6RN15
names: Subcellular Location Annotation
messages: Membrane

61622:PDK3
gene id: 61622:PDK3
uniprot id: A0A2K6QRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:DIPK1B
gene id: 61622:DIPK1B
uniprot id: A0A2K6P7E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

61622:ANXA1
gene id: 61622:ANXA1
uniprot id: A0A2K6RAX8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

61622:ADCYAP1
gene id: 61622:ADCYAP1
uniprot id: A0A2K6RHE1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucagon family.
messages: Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
messages: Secreted

61622:ASB2
gene id: 61622:ASB2
uniprot id: A0A2K6PI77
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:ASIP
gene id: 61622:ASIP
uniprot id: A0A2K6RSW9
names: Function
names: Subcellular Location Annotation
messages: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
messages: Secreted

61622:PIK3C3
gene id: 61622:PIK3C3
uniprot id: A0A2K6QT19
uniprot id: A0A2K6QT22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Midbody

61622:APOBEC3D
gene id: 61622:APOBEC3D
uniprot id: A0A2K6NVA4
names: Subcellular Location Annotation
messages: Cytoplasm

61622:MUS81
gene id: 61622:MUS81
uniprot id: A0A2K6RAS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

61622:EOGT
gene id: 61622:EOGT
uniprot id: A0A2K6P378
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

61622:UBE2G1
gene id: 61622:UBE2G1
uniprot id: A0A2K6N7W8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:CUTA
gene id: 61622:CUTA
uniprot id: A0A2K6NBU4
names: Similarity
names: Subunit
messages: Belongs to the CutA family.
messages: Homotrimer.

61622:ABRACL
gene id: 61622:ABRACL
uniprot id: A0A2K6QMT3
names: Similarity
messages: Belongs to the costars family.

61622:SFRP2
gene id: 61622:SFRP2
uniprot id: A0A2K6NDV1
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NR1H3
gene id: 61622:NR1H3
uniprot id: A0A2K6RWK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:PLA2G1B
gene id: 61622:PLA2G1B
uniprot id: A0A2K6RSU6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:WDR4
gene id: 61622:WDR4
uniprot id: A0A2K6QXP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat TRM82 family.
messages: Forms a heterodimer with the catalytic subunit METTL1.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

61622:CD3E
gene id: 61622:CD3E
uniprot id: A0A2K6P999
names: Subcellular Location Annotation
messages: Membrane

61622:TRIM63
gene id: 61622:TRIM63
uniprot id: A0A2K6R2M8
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104682851
gene id: 61622:LOC104682851
uniprot id: A0A2K6PBE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

61622:TTC39B
gene id: 61622:TTC39B
uniprot id: A0A2K6QL12
names: Similarity
messages: Belongs to the TTC39 family.

61622:CLDN11
gene id: 61622:CLDN11
uniprot id: A0A2K6P1G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:DPCD
gene id: 61622:DPCD
uniprot id: A0A2K6RMH4
names: Similarity
messages: Belongs to the DPCD family.

61622:AP3B2
gene id: 61622:AP3B2
uniprot id: A0A2K6P187
uniprot id: A0A2K6P192
uniprot id: A0A2K6P193
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

61622:PRDM10
gene id: 61622:PRDM10
uniprot id: A0A2K6PWE9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:MALL
gene id: 61622:MALL
uniprot id: A0A2K6NPR6
names: Subcellular Location Annotation
messages: Membrane

61622:KCNC1
gene id: 61622:KCNC1
uniprot id: A0A2K6NQS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:ALAS1
gene id: 61622:ALAS1
uniprot id: A0A2K6NEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

61622:MCMBP
gene id: 61622:MCMBP
uniprot id: A0A2K6NHK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

61622:WNT5B
gene id: 61622:WNT5B
uniprot id: A0A2K6RWI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:EVA1A
gene id: 61622:EVA1A
uniprot id: A0A2K6QGX9
names: Similarity
messages: Belongs to the EVA1 family.

61622:ECRG4
gene id: 61622:ECRG4
uniprot id: A0A2K6NNC5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the augurin family.
messages: Cytoplasm
messages: Membrane
messages: Secreted

61622:LCMT1
gene id: 61622:LCMT1
uniprot id: A0A2K6PUE7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

61622:CCNT2
gene id: 61622:CCNT2
uniprot id: A0A2K6QLN5
uniprot id: A0A2K6QLP9
names: Similarity
messages: Belongs to the cyclin family.

61622:ZSCAN23
gene id: 61622:ZSCAN23
uniprot id: A0A2K6RRD1
names: Subcellular Location Annotation
messages: Nucleus

61622:MS4A8
gene id: 61622:MS4A8
uniprot id: A0A2K6P5M2
names: Similarity
messages: Belongs to the MS4A family.

61622:APH1A
gene id: 61622:APH1A
uniprot id: A0A2K6RSM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

61622:GPS1
gene id: 61622:GPS1
uniprot id: A0A2K6P7J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN1 family.
messages: Cytoplasm
messages: Nucleus

61622:JRKL
gene id: 61622:JRKL
uniprot id: A0A2K6NQM0
names: Subcellular Location Annotation
messages: Nucleus

61622:ACER2
gene id: 61622:ACER2
uniprot id: A0A2K6P3V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:WASHC5
gene id: 61622:WASHC5
uniprot id: A0A2K6QXF4
names: Similarity
messages: Belongs to the strumpellin family.

61622:TOMM20
gene id: 61622:TOMM20
uniprot id: A0A2K6PK91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:CPLX4
gene id: 61622:CPLX4
uniprot id: A0A2K6PMY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61622:UTP14A
gene id: 61622:UTP14A
uniprot id: A0A2K6NVY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP14 family.
messages: nucleolus

61622:ERO1A
gene id: 61622:ERO1A
uniprot id: A0A2K6RDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane

61622:CDC25A
gene id: 61622:CDC25A
uniprot id: A0A2K6RHB3
uniprot id: A0A2K6RHC5
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

61622:TNFSF4
gene id: 61622:TNFSF4
uniprot id: A0A2K6QPS8
uniprot id: A0A2K6QPT6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:TATDN2
gene id: 61622:TATDN2
uniprot id: A0A2K6QJR8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

61622:SLA
gene id: 61622:SLA
uniprot id: A0A2K6RV44
uniprot id: A0A2K6RV65
names: Subcellular Location Annotation
messages: Cytoplasm

61622:KIF11
gene id: 61622:KIF11
uniprot id: A0A2K6QX16
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:HIBCH
gene id: 61622:HIBCH
uniprot id: A0A2K6QAM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

61622:PDE6D
gene id: 61622:PDE6D
uniprot id: A0A2K6NXT8
uniprot id: A0A2K6NXU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDE6D/unc-119 family.
messages: Cytoplasmic vesicle membrane
messages: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains and two inhibitory chains; has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane.
messages: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
messages: cilium basal body
messages: cytosol

61622:GALK1
gene id: 61622:GALK1
uniprot id: A0A2K6NWI5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

61622:KRT9
gene id: 61622:KRT9
uniprot id: A0A2K6R473
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SH3KBP1
gene id: 61622:SH3KBP1
uniprot id: A0A2K6PVD3
uniprot id: A0A2K6PVE6
uniprot id: A0A2K6PVE7
names: Subcellular Location Annotation
messages: focal adhesion

61622:CA2
gene id: 61622:CA2
uniprot id: A0A2K6P5L5
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61622:SEC61G
gene id: 61622:SEC61G
uniprot id: A0A2K6N728
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:RRP1
gene id: 61622:RRP1
uniprot id: A0A2K6QU25
names: Similarity
messages: Belongs to the RRP1 family.

61622:CPVL
gene id: 61622:CPVL
uniprot id: A0A2K6R8H3
names: Similarity
messages: Belongs to the peptidase S10 family.

61622:C14H2orf88
gene id: 61622:C14H2orf88
uniprot id: A0A2K6NQR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small membrane AKAP family.
messages: Cell membrane
messages: Membrane

61622:STEAP4
gene id: 61622:STEAP4
uniprot id: A0A2K6NKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

61622:ETFB
gene id: 61622:ETFB
uniprot id: A0A2K6R4H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

61622:CHMP2B
gene id: 61622:CHMP2B
uniprot id: A0A2K6PDR8
names: Similarity
messages: Belongs to the SNF7 family.

61622:MRPL27
gene id: 61622:MRPL27
uniprot id: A0A2K6P9A1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

61622:CDO1
gene id: 61622:CDO1
uniprot id: A0A2K6NHX6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

61622:GSTP1
gene id: 61622:GSTP1
uniprot id: A0A2K6NSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

61622:LOC104659773
gene id: 61622:LOC104659773
uniprot id: A0A2K6P4W5
names: Similarity
messages: Belongs to the histone H2B family.

61622:ASB3
gene id: 61622:ASB3
uniprot id: A0A2K6RR63
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:LOC104665503
gene id: 61622:LOC104665503
uniprot id: A0A2K6NNK3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:CHRNG
gene id: 61622:CHRNG
uniprot id: A0A2K6PVA8
uniprot id: A0A2K6PVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:LSM6
gene id: 61622:LSM6
uniprot id: A0A2K6NPM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

61622:EDN3
gene id: 61622:EDN3
uniprot id: A0A2K6R2B3
uniprot id: A0A2K6R2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

61622:TM2D3
gene id: 61622:TM2D3
uniprot id: A0A2K6RUH2
uniprot id: A0A2K6RUI1
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104673589
gene id: 61622:LOC104673589
uniprot id: A0A2K6R4V5
names: Similarity
messages: Belongs to the MHC class I family.

61622:MED1
gene id: 61622:MED1
uniprot id: A0A2K6QMC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

61622:RPS20
gene id: 61622:RPS20
uniprot id: A0A2K6PWQ6
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

61622:GSTCD
gene id: 61622:GSTCD
uniprot id: A0A2K6Q3F2
names: Similarity
messages: Belongs to the GSTCD family.

61622:PEX5L
gene id: 61622:PEX5L
uniprot id: A0A2K6QLR1
uniprot id: A0A2K6QLS1
uniprot id: A0A2K6QLS7
uniprot id: A0A2K6QLT4
uniprot id: A0A2K6QLU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

61622:NR3C2
gene id: 61622:NR3C2
uniprot id: A0A2K6PWX7
names: Subcellular Location Annotation
messages: Nucleus

61622:MAF1
gene id: 61622:MAF1
uniprot id: A0A2K6RTI6
uniprot id: A0A2K6RTJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

61622:GDF15
gene id: 61622:GDF15
uniprot id: A0A2K6PFL0
names: Similarity
messages: Belongs to the TGF-beta family.

61622:PIPOX
gene id: 61622:PIPOX
uniprot id: A0A2K6NNW8
names: Similarity
messages: Belongs to the MSOX/MTOX family.

61622:TAT
gene id: 61622:TAT
uniprot id: A0A2K6Q2I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

61622:GET4
gene id: 61622:GET4
uniprot id: A0A2K6NC42
uniprot id: A0A2K6NC55
names: Similarity
messages: Belongs to the GET4 family.

61622:ASPM
gene id: 61622:ASPM
uniprot id: A0A2K6RDX7
uniprot id: A0A2K6RDZ0
names: Subcellular Location Annotation
messages: Nucleus
messages: spindle

61622:ARRB2
gene id: 61622:ARRB2
uniprot id: A0A2K6QR23
names: Similarity
messages: Belongs to the arrestin family.

61622:SKIL
gene id: 61622:SKIL
uniprot id: A0A2K6RP06
names: Similarity
messages: Belongs to the SKI family.

61622:AASDHPPT
gene id: 61622:AASDHPPT
uniprot id: A0A2K6QUN7
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

61622:DYNLT3
gene id: 61622:DYNLT3
uniprot id: A0A2K6QTC3
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:CXCL8
gene id: 61622:CXCL8
uniprot id: A0A2K6RUC7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

61622:ACKR1
gene id: 61622:ACKR1
uniprot id: L7WMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
messages: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
messages: Early endosome
messages: Membrane
messages: Recycling endosome

61622:MITF
gene id: 61622:MITF
uniprot id: A0A2K6P6S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61622:TSPAN8
gene id: 61622:TSPAN8
uniprot id: A0A2K6NCY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:OLA1
gene id: 61622:OLA1
uniprot id: A0A2K6QL59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.
messages: Nucleus
messages: nucleolus

61622:MRPL9
gene id: 61622:MRPL9
uniprot id: A0A2K6PB53
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

61622:STK11
gene id: 61622:STK11
uniprot id: A0A2K6NMW4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.

61622:KIF22
gene id: 61622:KIF22
uniprot id: A0A2K6R385
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:KCNAB2
gene id: 61622:KCNAB2
uniprot id: A0A2K6RPI4
uniprot id: A0A2K6RPI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: axon
messages: cytoskeleton
messages: synaptosome

61622:SEC24D
gene id: 61622:SEC24D
uniprot id: A0A2K6PWP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61622:SNUPN
gene id: 61622:SNUPN
uniprot id: A0A2K6RII2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

61622:LOC104669497
gene id: 61622:LOC104669497
uniprot id: A0A2K6RUJ7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61622:SNX4
gene id: 61622:SNX4
uniprot id: A0A2K6NEV3
names: Similarity
messages: Belongs to the sorting nexin family.

61622:TSPAN12
gene id: 61622:TSPAN12
uniprot id: A0A2K6PAV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:HEXIM2
gene id: 61622:HEXIM2
uniprot id: A0A2K6R7Y3
uniprot id: A0A2K6R7Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

61622:PDSS1
gene id: 61622:PDSS1
uniprot id: A0A2K6PKB6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61622:LOC104666003
gene id: 61622:LOC104666003
uniprot id: A0A2K6NS74
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:LOC104665939
gene id: 61622:LOC104665939
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:SLC31A1
gene id: 61622:SLC31A1
uniprot id: A0A2K6P9R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

61622:EMP3
gene id: 61622:EMP3
uniprot id: A0A2K6QTS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

61622:ATPAF2
gene id: 61622:ATPAF2
uniprot id: A0A2K6PFR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

61622:DNMT3L
gene id: 61622:DNMT3L
uniprot id: A0A2K6Q0D0
names: Subcellular Location Annotation
messages: Nucleus

61622:PGS1
gene id: 61622:PGS1
uniprot id: A0A2K6NHE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

61622:MTAP
gene id: 61622:MTAP
uniprot id: A0A2K6NAK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

61622:ADAMTS4
gene id: 61622:ADAMTS4
uniprot id: A0A2K6P9V1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:CLIC6
gene id: 61622:CLIC6
uniprot id: A0A2K6RNL4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:GOSR2
gene id: 61622:GOSR2
uniprot id: A0A2K6PJ94
uniprot id: A0A2K6PJF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

61622:RNF121
gene id: 61622:RNF121
uniprot id: A0A2K6N8R2
names: Subcellular Location Annotation
messages: Membrane

61622:IWS1
gene id: 61622:IWS1
uniprot id: A0A2K6NW24
names: Subcellular Location Annotation
messages: Nucleus

61622:ADGRG1
gene id: 61622:ADGRG1
uniprot id: A0A2K6RWF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Secreted

61622:CKM
gene id: 61622:CKM
uniprot id: A0A2K6RHM6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

61622:PLAG1
gene id: 61622:PLAG1
uniprot id: A0A2K6PF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

61622:DHX58
gene id: 61622:DHX58
uniprot id: A0A2K6Q5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

61622:NUP133
gene id: 61622:NUP133
uniprot id: A0A2K6NAD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

61622:LYPD5
gene id: 61622:LYPD5
uniprot id: A0A2K6RVR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:C5H15orf65
gene id: 61622:C5H15orf65
uniprot id: A0A2K6Q0C9
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

61622:CTSC
gene id: 61622:CTSC
uniprot id: A0A2K6NZ23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

61622:KHDC3L
gene id: 61622:KHDC3L
uniprot id: A0A2K6PBK0
names: Similarity
messages: Belongs to the KHDC1 family.

61622:GDPD2
gene id: 61622:GDPD2
uniprot id: A0A2K6PVQ9
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:PPIP5K2
gene id: 61622:PPIP5K2
uniprot id: A0A2K6R7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

61622:TUBA8
gene id: 61622:TUBA8
uniprot id: A0A2K6NP71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61622:SORBS2
gene id: 61622:SORBS2
uniprot id: A0A2K6NL60
uniprot id: A0A2K6NL65
uniprot id: A0A2K6NL68
uniprot id: A0A2K6NL74
names: Subcellular Location Annotation
messages: focal adhesion

61622:DSG1
gene id: 61622:DSG1
uniprot id: A0A2K6NA25
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:SLC26A7
gene id: 61622:SLC26A7
uniprot id: A0A2K6PBS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

61622:IMPAD1
gene id: 61622:IMPAD1
uniprot id: A0A2K6NVK8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:LOC104673941
gene id: 61622:LOC104673941
uniprot id: A0A2K6R1N6
names: Subcellular Location Annotation
messages: Nucleus

61622:TFCP2
gene id: 61622:TFCP2
uniprot id: A0A2K6QDU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61622:CHST8
gene id: 61622:CHST8
uniprot id: A0A2K6QJS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:TAF9B
gene id: 61622:TAF9B
uniprot id: A0A2K6PGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

61622:LOC104673294
gene id: 61622:LOC104673294
uniprot id: A0A2K6QW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

61622:TM9SF1
gene id: 61622:TM9SF1
uniprot id: A0A2K6RB96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

61622:SLC6A12
gene id: 61622:SLC6A12
uniprot id: A0A2K6NCU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Interacts with LIN7C.
messages: Membrane
messages: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

61622:HSPH1
gene id: 61622:HSPH1
uniprot id: A0A2K6PKJ1
uniprot id: A0A2K6PKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

61622:POLRMT
gene id: 61622:POLRMT
uniprot id: A0A2K6R0G2
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61622:WNT16
gene id: 61622:WNT16
uniprot id: A0A2K6PIA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:LOC104666890
gene id: 61622:LOC104666890
uniprot id: A0A2K6RHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

61622:UBALD1
gene id: 61622:UBALD1
uniprot id: A0A2K6QB26
names: Similarity
messages: Belongs to the UBALD family.

61622:PARP9
gene id: 61622:PARP9
uniprot id: A0A2K6RM72
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:LOC104676097
gene id: 61622:LOC104676097
uniprot id: A0A2K6NPW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:VCAN
gene id: 61622:VCAN
uniprot id: A0A2K6NXP3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:TYMS
gene id: 61622:TYMS
uniprot id: A0A2K6PR41
names: Similarity
messages: Belongs to the thymidylate synthase family.

61622:KRT84
gene id: 61622:KRT84
uniprot id: A0A2K6NZ69
names: Similarity
messages: Belongs to the intermediate filament family.

61622:TEKT5
gene id: 61622:TEKT5
uniprot id: A0A2K6QRP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

61622:NAP1L1
gene id: 61622:NAP1L1
uniprot id: A0A2K6NRU5
uniprot id: A0A2K6NRU7
uniprot id: A0A2K6NRV6
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61622:LOC104667643
gene id: 61622:LOC104667643
uniprot id: A0A2K6RAV0
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

61622:CERS5
gene id: 61622:CERS5
uniprot id: A0A2K6NEZ5
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61622:CACNA1D
gene id: 61622:CACNA1D
uniprot id: A0A2K6Q3E6
uniprot id: A0A2K6Q3F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

61622:THBS1
gene id: 61622:THBS1
uniprot id: A0A2K6RQ14
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ESRRB
gene id: 61622:ESRRB
uniprot id: A0A2K6PUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61622:NPR3
gene id: 61622:NPR3
uniprot id: A0A2K6QFQ6
uniprot id: A0A2K6QFS5
names: Subcellular Location Annotation
messages: Membrane

61622:TMPRSS15
gene id: 61622:TMPRSS15
uniprot id: A0A2K6RKC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMBT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ZIC1
gene id: 61622:ZIC1
uniprot id: A0A2K6PC19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

61622:AGO3
gene id: 61622:AGO3
uniprot id: A0A2K6R9H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

61622:IRF1
gene id: 61622:IRF1
uniprot id: A0A2K6R6F4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:GRK1
gene id: 61622:GRK1
uniprot id: A0A2K6PMB6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61622:PTHLH
gene id: 61622:PTHLH
uniprot id: A0A2K6Q2L0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

61622:TAF6
gene id: 61622:TAF6
uniprot id: A0A2K6N7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

61622:CTNND2
gene id: 61622:CTNND2
uniprot id: A0A2K6NNH4
names: Similarity
messages: Belongs to the beta-catenin family.

61622:ATP5PO
gene id: 61622:ATP5PO
uniprot id: A0A2K6PVG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

61622:SNX6
gene id: 61622:SNX6
uniprot id: A0A2K6Q145
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

61622:STAM2
gene id: 61622:STAM2
uniprot id: A0A2K6P9Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

61622:CHMP7
gene id: 61622:CHMP7
uniprot id: A0A2K6NI07
names: Similarity
messages: Belongs to the SNF7 family.

61622:STARD3NL
gene id: 61622:STARD3NL
uniprot id: A0A2K6NS33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:EMX1
gene id: 61622:EMX1
uniprot id: A0A2K6QKZ7
names: Subcellular Location Annotation
messages: Nucleus

61622:FNIP2
gene id: 61622:FNIP2
uniprot id: A0A2K6NHA8
uniprot id: A0A2K6NHB3
uniprot id: A0A2K6NHD3
uniprot id: A0A2K6NHD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

61622:KEG34 p09
gene id: 61622:KEG34_p09
uniprot id: Q15GN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase protein 8 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

61622:LOC104666732
gene id: 61622:LOC104666732
uniprot id: A0A2K6NEF4
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LOC104668837
gene id: 61622:LOC104668837
uniprot id: A0A2K6PYM3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

61622:LOC104663585
gene id: 61622:LOC104663585
uniprot id: A0A2K6NMG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CCDC93
gene id: 61622:CCDC93
uniprot id: A0A2K6P966
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC93 family.
messages: Early endosome

61622:SCN11A
gene id: 61622:SCN11A
uniprot id: A0A2K6R440
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

61622:CREG1
gene id: 61622:CREG1
uniprot id: A0A2K6P9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

61622:TMEM178B
gene id: 61622:TMEM178B
uniprot id: A0A2K6QUZ6
names: Similarity
messages: Belongs to the TMEM178 family.

61622:TBX10
gene id: 61622:TBX10
uniprot id: A0A2K6QTG5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:NUP62CL
gene id: 61622:NUP62CL
uniprot id: A0A2K6P3N7
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

61622:DTD1
gene id: 61622:DTD1
uniprot id: A0A2K6QSJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

61622:CDADC1
gene id: 61622:CDADC1
uniprot id: A0A2K6PIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

61622:HOXB13
gene id: 61622:HOXB13
uniprot id: A0A2K6R8U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:WNT5A
gene id: 61622:WNT5A
uniprot id: A0A2K6PGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:CCDC86
gene id: 61622:CCDC86
uniprot id: A0A2K6RF38
names: Subcellular Location Annotation
messages: Nucleus

61622:FLT1
gene id: 61622:FLT1
uniprot id: A0A2K6RLG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

61622:SMC4
gene id: 61622:SMC4
uniprot id: A0A2K6PWS1
uniprot id: A0A2K6PWS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC4 subfamily.
messages: Chromosome
messages: Nucleus

61622:ERH
gene id: 61622:ERH
uniprot id: A0A2K6PL71
names: Function
names: Similarity
messages: Belongs to the E(R) family.
messages: May have a role in the cell cycle.

61622:OCA2
gene id: 61622:OCA2
uniprot id: A0A2K6PF79
names: Subcellular Location Annotation
messages: Membrane

61622:NOS3
gene id: 61622:NOS3
uniprot id: A0A2K6PX93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NOS family.
messages: Binds 1 FAD.
messages: Binds 1 FMN.
messages: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body.

61622:CCNE2
gene id: 61622:CCNE2
uniprot id: A0A2K6PMN8
names: Similarity
messages: Belongs to the cyclin family. Cyclin E subfamily.

61622:BCL2L13
gene id: 61622:BCL2L13
uniprot id: A0A2K6PJW0
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:NAPA
gene id: 61622:NAPA
uniprot id: A0A2K6QEL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

61622:PPP1R15B
gene id: 61622:PPP1R15B
uniprot id: A0A2K6QZ95
names: Similarity
messages: Belongs to the PPP1R15 family.

61622:PTPRZ1
gene id: 61622:PTPRZ1
uniprot id: A0A2K6NIZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

61622:TRMT5
gene id: 61622:TRMT5
uniprot id: A0A2K6Q2D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

61622:STAM
gene id: 61622:STAM
uniprot id: A0A2K6Q9U6
uniprot id: A0A2K6Q9U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

61622:RPAP1
gene id: 61622:RPAP1
uniprot id: A0A2K6PW94
names: Similarity
messages: Belongs to the RPAP1 family.

61622:TLR3
gene id: 61622:TLR3
uniprot id: A0A2K6NBK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61622:TMEM147
gene id: 61622:TMEM147
uniprot id: A0A2K6PCT5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:EYA2
gene id: 61622:EYA2
uniprot id: A0A2K6NRS2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

61622:SNPH
gene id: 61622:SNPH
uniprot id: A0A2K6PK39
names: Subcellular Location Annotation
messages: Membrane

61622:LMOD3
gene id: 61622:LMOD3
uniprot id: A0A2K6PKW2
names: Subcellular Location Annotation
messages: cytoskeleton

61622:EEF2KMT
gene id: 61622:EEF2KMT
uniprot id: A0A2K6QTB4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

61622:PLSCR1
gene id: 61622:PLSCR1
uniprot id: A0A2K6QJC1
uniprot id: A0A2K6QJD0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:B4GALNT2
gene id: 61622:B4GALNT2
uniprot id: A0A2K6N834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

61622:ALX1
gene id: 61622:ALX1
uniprot id: A0A2K6NGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61622:NCEH1
gene id: 61622:NCEH1
uniprot id: A0A2K6NAX7
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61622:CD40LG
gene id: 61622:CD40LG
uniprot id: A0A2K6R4L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface
messages: Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
messages: Homotrimer.

61622:DYNLL1
gene id: 61622:DYNLL1
uniprot id: A0A2K6N9P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

61622:PHYHIPL
gene id: 61622:PHYHIPL
uniprot id: A0A2K6R1F9
names: Similarity
messages: Belongs to the PHYHIP family.

61622:LSS
gene id: 61622:LSS
uniprot id: A0A2K6QYG0
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

61622:SARS2
gene id: 61622:SARS2
uniprot id: A0A2K6PHJ1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

61622:PI4KA
gene id: 61622:PI4KA
uniprot id: A0A2K6Q753
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:IL4I1
gene id: 61622:IL4I1
uniprot id: A0A2K6QLL1
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

61622:LTK
gene id: 61622:LTK
uniprot id: A0A2K6PM76
uniprot id: A0A2K6PM85
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

61622:TP53INP2
gene id: 61622:TP53INP2
uniprot id: A0A2K6QY60
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

61622:PDE1C
gene id: 61622:PDE1C
uniprot id: A0A2K6RN88
uniprot id: A0A2K6RN89
uniprot id: A0A2K6RNB4
uniprot id: A0A2K6RNC8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:PHAX
gene id: 61622:PHAX
uniprot id: A0A2K6NJY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

61622:LNPEP
gene id: 61622:LNPEP
uniprot id: A0A2K6NW04
names: Similarity
messages: Belongs to the peptidase M1 family.

61622:MYH4
gene id: 61622:MYH4
uniprot id: A0A2K6PC10
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:NPAS4
gene id: 61622:NPAS4
uniprot id: A0A2K6PF19
names: Subcellular Location Annotation
messages: Nucleus

61622:ARR3
gene id: 61622:ARR3
uniprot id: A0A2K6R475
names: Function
names: Similarity
messages: Belongs to the arrestin family.
messages: May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins.

61622:SLC26A4
gene id: 61622:SLC26A4
uniprot id: A0A2K6RM77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Sodium-independent transporter of chloride and iodide.

61622:CDA
gene id: 61622:CDA
uniprot id: A0A2K6P171
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

61622:LAMTOR1
gene id: 61622:LAMTOR1
uniprot id: A0A2K6RK37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61622:GLIPR1
gene id: 61622:GLIPR1
uniprot id: A0A2K6RGS3
names: Similarity
messages: Belongs to the CRISP family.

61622:LOC104661958
gene id: 61622:LOC104661958
uniprot id: A0A2K6NL88
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

61622:MGAT4C
gene id: 61622:MGAT4C
uniprot id: A0A2K6NJ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 54 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:LOC104679721
gene id: 61622:LOC104679721
uniprot id: A0A2K6N815
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61622:IRF9
gene id: 61622:IRF9
uniprot id: A0A2K6P094
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:MON1B
gene id: 61622:MON1B
uniprot id: A0A2K6P7L8
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

61622:ELMO1
gene id: 61622:ELMO1
uniprot id: A0A2K6R663
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

61622:CCDC25
gene id: 61622:CCDC25
uniprot id: A0A2K6NVB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

61622:CAP1
gene id: 61622:CAP1
uniprot id: A0A2K6QEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
messages: Homodimer. Binds actin monomers.
messages: Membrane

61622:SNRPB
gene id: 61622:SNRPB
uniprot id: A0A2K6Q726
uniprot id: A0A2K6Q736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

61622:EYA4
gene id: 61622:EYA4
uniprot id: A0A2K6PZR6
uniprot id: A0A2K6PZS3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Nucleus

61622:LOC104675130
gene id: 61622:LOC104675130
uniprot id: A0A2K6QA16
names: Similarity
messages: Belongs to the SCO1/2 family.

61622:AIFM1
gene id: 61622:AIFM1
uniprot id: A0A2K6QDZ6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

61622:MCM2
gene id: 61622:MCM2
uniprot id: A0A2K6RA76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

61622:EMC3
gene id: 61622:EMC3
uniprot id: A0A2K6PYP9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC3 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Membrane

61622:PCCA
gene id: 61622:PCCA
uniprot id: A0A2K6PA55
names: Subcellular Location Annotation
messages: Mitochondrion matrix

61622:ARSB
gene id: 61622:ARSB
uniprot id: A0A2K6PJN1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:CDIPT
gene id: 61622:CDIPT
uniprot id: A0A2K6P2B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

61622:FAM193B
gene id: 61622:FAM193B
uniprot id: A0A2K6P418
names: Similarity
messages: Belongs to the FAM193 family.

61622:MED6
gene id: 61622:MED6
uniprot id: A0A2K6NHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61622:ZNF449
gene id: 61622:ZNF449
uniprot id: A0A2K6P5N0
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104677181
gene id: 61622:LOC104677181
uniprot id: A0A2K6RDU9
names: Similarity
messages: Belongs to the SPAN-X family.

61622:RNASET2
gene id: 61622:RNASET2
uniprot id: A0A2K6PZ56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

61622:PARVA
gene id: 61622:PARVA
uniprot id: A0A2K6Q8E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane
messages: cytoskeleton

61622:LOC104679652
gene id: 61622:LOC104679652
uniprot id: A0A2K6PXN8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

61622:FGD6
gene id: 61622:FGD6
uniprot id: A0A2K6PJ18
names: Subcellular Location Annotation
messages: cytoskeleton

61622:PNPO
gene id: 61622:PNPO
uniprot id: A0A2K6RKX8
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

61622:CREBL2
gene id: 61622:CREBL2
uniprot id: A0A2K6NX81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

61622:TCEANC2
gene id: 61622:TCEANC2
uniprot id: A0A2K6NF03
names: Subcellular Location Annotation
messages: Nucleus

61622:ZNF18
gene id: 61622:ZNF18
uniprot id: A0A2K6NBG5
names: Subcellular Location Annotation
messages: Nucleus

61622:ADCK1
gene id: 61622:ADCK1
uniprot id: A0A2K6PC84
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

61622:ERGIC2
gene id: 61622:ERGIC2
uniprot id: A0A2K6NIM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

61622:LOC104677200
gene id: 61622:LOC104677200
uniprot id: A0A2K6NEA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CA9
gene id: 61622:CA9
uniprot id: A0A2K6RHV1
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61622:FLOT1
gene id: 61622:FLOT1
uniprot id: A0A2K6PBZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.
messages: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
messages: Membrane
messages: Membrane raft
messages: caveola

61622:PRICKLE3
gene id: 61622:PRICKLE3
uniprot id: A0A2K6Q742
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

61622:DDAH1
gene id: 61622:DDAH1
uniprot id: A0A2K6NDV0
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

61622:URAD
gene id: 61622:URAD
uniprot id: A0A2K6PIX8
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

61622:CLCA2
gene id: 61622:CLCA2
uniprot id: A0A2K6PL34
names: Similarity
messages: Belongs to the CLCR family.

61622:SCRN1
gene id: 61622:SCRN1
uniprot id: A0A2K6NQH1
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

61622:LOC104675208
gene id: 61622:LOC104675208
uniprot id: A0A2K6NPH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

61622:GADD45B
gene id: 61622:GADD45B
uniprot id: A0A2K6R6K7
names: Similarity
messages: Belongs to the GADD45 family.

61622:PPP2R5E
gene id: 61622:PPP2R5E
uniprot id: A0A2K6NN28
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61622:CSNK2A1
gene id: 61622:CSNK2A1
uniprot id: A0A2K6RBA3
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TXNRD1
gene id: 61622:TXNRD1
uniprot id: A0A2K6PYF3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

61622:TBX5
gene id: 61622:TBX5
uniprot id: A0A2K6QYD1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:WNT2
gene id: 61622:WNT2
uniprot id: A0A2K6NI98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:LOC104656374
gene id: 61622:LOC104656374
uniprot id: A0A2K6NVD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SAT1
gene id: 61622:SAT1
uniprot id: A0A2K6RCG6
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

61622:BCKDHA
gene id: 61622:BCKDHA
uniprot id: A0A2K6QXC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BCKDHA family.
messages: Heterotetramer of alpha and beta chains.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

61622:POP7
gene id: 61622:POP7
uniprot id: A0A2K6NV88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone-like Alba family.
messages: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
messages: Cytoplasmic granule
messages: nucleolus

61622:AP3M2
gene id: 61622:AP3M2
uniprot id: A0A2K6PJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

61622:ZDHHC24
gene id: 61622:ZDHHC24
uniprot id: A0A2K6QNH4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:GLRB
gene id: 61622:GLRB
uniprot id: A0A2K6QVC4
uniprot id: A0A2K6QVF6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FURIN
gene id: 61622:FURIN
uniprot id: A0A2K6Q7Q7
names: Similarity
messages: Belongs to the peptidase S8 family.

61622:OCLN
gene id: 61622:OCLN
uniprot id: A0A2K6R531
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

61622:FAS
gene id: 61622:FAS
uniprot id: A0A2K6QCZ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

61622:NT5DC1
gene id: 61622:NT5DC1
uniprot id: A0A2K6PK93
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

61622:CCL20
gene id: 61622:CCL20
uniprot id: A0A2K6PK32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:UCMA
gene id: 61622:UCMA
uniprot id: A0A2K6NIL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UCMA family.
messages: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
messages: extracellular matrix

61622:LOC104675001
gene id: 61622:LOC104675001
uniprot id: A0A2K6QPS6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

61622:ZBTB8OS
gene id: 61622:ZBTB8OS
uniprot id: A0A2K6QLV1
names: Similarity
names: Subunit
messages: Belongs to the archease family.
messages: Component of the tRNA-splicing ligase complex.

61622:PEX3
gene id: 61622:PEX3
uniprot id: A0A2K6QSS7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

61622:SEC11A
gene id: 61622:SEC11A
uniprot id: A0A2K6QPB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CCDC167
gene id: 61622:CCDC167
uniprot id: A0A2K6PFE6
names: Subcellular Location Annotation
messages: Membrane

61622:CAST
gene id: 61622:CAST
uniprot id: A0A2K6RN46
uniprot id: A0A2K6RN52
uniprot id: A0A2K6RN63
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

61622:MPP6
gene id: 61622:MPP6
uniprot id: A0A2K6QDG0
names: Similarity
messages: Belongs to the MAGUK family.

61622:SLC25A3
gene id: 61622:SLC25A3
uniprot id: A0A2K6PLG5
uniprot id: A0A2K6PLH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Interacts with PPIF; the interaction is impaired by CsA.
messages: Membrane
messages: Mitochondrion inner membrane

61622:ORC5
gene id: 61622:ORC5
uniprot id: A0A2K6PSK8
names: Subcellular Location Annotation
messages: Nucleus

61622:TM6SF2
gene id: 61622:TM6SF2
uniprot id: A0A2K6QAR6
uniprot id: A0A2K6QAT8
names: Subcellular Location Annotation
messages: Membrane

61622:EGFR
gene id: 61622:EGFR
uniprot id: A0A2K6R6K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

61622:PITHD1
gene id: 61622:PITHD1
uniprot id: A0A2K6QU74
names: Similarity
messages: Belongs to the PITHD1 family.

61622:CHPT1
gene id: 61622:CHPT1
uniprot id: A0A2K6QQ76
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

61622:COPG1
gene id: 61622:COPG1
uniprot id: A0A2K6PGK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

61622:SNU13
gene id: 61622:SNU13
uniprot id: A0A2K6RBG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

61622:TMEM121B
gene id: 61622:TMEM121B
uniprot id: A0A2K6NSD0
names: Similarity
messages: Belongs to the TMEM121 family.

61622:PTK7
gene id: 61622:PTK7
uniprot id: A0A2K6RDN0
names: Subcellular Location Annotation
messages: Membrane

61622:NAA40
gene id: 61622:NAA40
uniprot id: A0A2K6QYW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

61622:GNS
gene id: 61622:GNS
uniprot id: A0A2K6P0D0
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:GLIPR1L1
gene id: 61622:GLIPR1L1
uniprot id: A0A2K6QQR5
uniprot id: A0A2K6QQU6
names: Similarity
messages: Belongs to the CRISP family.

61622:E2F5
gene id: 61622:E2F5
uniprot id: A0A2K6PSU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:ANKRD34C
gene id: 61622:ANKRD34C
uniprot id: A0A2K6QJU6
names: Similarity
messages: Belongs to the ANKRD34 family.

61622:TOMM20L
gene id: 61622:TOMM20L
uniprot id: A0A2K6QVT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:TMPO
gene id: 61622:TMPO
uniprot id: A0A2K6NTW8
uniprot id: A0A2K6NTY1
uniprot id: A0A2K6NTY2
names: Similarity
messages: Belongs to the LEM family.

61622:LYRM1
gene id: 61622:LYRM1
uniprot id: A0A2K6RAA7
names: Similarity
messages: Belongs to the complex I LYR family.

61622:ABR
gene id: 61622:ABR
uniprot id: A0A2K6PTE3
uniprot id: A0A2K6PTE8
uniprot id: A0A2K6PTG7
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

61622:CACNG7
gene id: 61622:CACNG7
uniprot id: A0A2K6PEA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2.

61622:TEK
gene id: 61622:TEK
uniprot id: A0A2K6P0H1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SF3A3
gene id: 61622:SF3A3
uniprot id: A0A2K6PTM1
names: Similarity
messages: Belongs to the SF3A3 family.

61622:ZMYND10
gene id: 61622:ZMYND10
uniprot id: A0A2K6QI17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the ZMYND10 family.
messages: Dynein axonemal particle
messages: Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
messages: centriolar satellite

61622:TMED6
gene id: 61622:TMED6
uniprot id: A0A2K6NB36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:FOXI2
gene id: 61622:FOXI2
uniprot id: A0A2K6QWD7
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104670633
gene id: 61622:LOC104670633
uniprot id: A0A2K6PY32
names: Similarity
messages: Belongs to the intermediate filament family.

61622:LANCL2
gene id: 61622:LANCL2
uniprot id: A0A2K6Q9N3
names: Similarity
messages: Belongs to the LanC-like protein family.

61622:LSM4
gene id: 61622:LSM4
uniprot id: A0A2K6RX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

61622:ADAM10
gene id: 61622:ADAM10
uniprot id: A0A2K6QWF8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: adherens junction

61622:KRT82
gene id: 61622:KRT82
uniprot id: A0A2K6PLE8
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PROKR2
gene id: 61622:PROKR2
uniprot id: A0A2K6RJ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:PPP3CB
gene id: 61622:PPP3CB
uniprot id: A0A2K6PI52
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

61622:GALNTL6
gene id: 61622:GALNTL6
uniprot id: A0A2K6RHB5
uniprot id: A0A2K6RHC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:MYO1B
gene id: 61622:MYO1B
uniprot id: A0A2K6PH97
uniprot id: A0A2K6PHB8
uniprot id: A0A2K6PHI4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:THY1
gene id: 61622:THY1
uniprot id: A0A2K6PXS3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

61622:ZNF174
gene id: 61622:ZNF174
uniprot id: A0A2K6QMF9
names: Subcellular Location Annotation
messages: Nucleus

61622:PCK2
gene id: 61622:PCK2
uniprot id: A0A2K6NC65
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

61622:TTLL1
gene id: 61622:TTLL1
uniprot id: A0A2K6PVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin polyglutamylase family.
messages: cilium basal body

61622:EIF4A2
gene id: 61622:EIF4A2
uniprot id: A0A2K6PQM1
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

61622:LOC104674542
gene id: 61622:LOC104674542
uniprot id: A0A2K6NKL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

61622:OGDH
gene id: 61622:OGDH
uniprot id: A0A2K6PGN5
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

61622:RRM2
gene id: 61622:RRM2
uniprot id: A0A2K6R3U1
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

61622:CLTB
gene id: 61622:CLTB
uniprot id: A0A2K6R5R2
uniprot id: A0A2K6R5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

61622:SLC5A5
gene id: 61622:SLC5A5
uniprot id: A0A2K6PBP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:QSOX1
gene id: 61622:QSOX1
uniprot id: A0A2K6RE49
uniprot id: A0A2K6RE53
names: Function
names: Similarity
messages: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
messages: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.

61622:KCTD20
gene id: 61622:KCTD20
uniprot id: A0A2K6RBN8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:AHCY
gene id: 61622:AHCY
uniprot id: A0A2K6Q2C3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

61622:STMN4
gene id: 61622:STMN4
uniprot id: A0A2K6RD51
uniprot id: A0A2K6RD61
uniprot id: A0A2K6RD90
names: Similarity
messages: Belongs to the stathmin family.

61622:ARPC3
gene id: 61622:ARPC3
uniprot id: A0A2K6P4J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

61622:PRKAR1B
gene id: 61622:PRKAR1B
uniprot id: A0A2K6PPI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61622:RFC5
gene id: 61622:RFC5
uniprot id: A0A2K6QWG2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

61622:DHRS7C
gene id: 61622:DHRS7C
uniprot id: A0A2K6RM50
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:WNT3
gene id: 61622:WNT3
uniprot id: A0A2K6QK28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:INTS10
gene id: 61622:INTS10
uniprot id: A0A2K6PFN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 10 family.
messages: Nucleus

61622:SLC1A4
gene id: 61622:SLC1A4
uniprot id: A0A2K6PGT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

61622:ENKUR
gene id: 61622:ENKUR
uniprot id: A0A2K6PTD6
uniprot id: A0A2K6PTE5
names: Subcellular Location Annotation
messages: cilium axoneme

61622:SURF6
gene id: 61622:SURF6
uniprot id: A0A2K6NFX6
names: Similarity
messages: Belongs to the SURF6 family.

61622:EPHB6
gene id: 61622:EPHB6
uniprot id: A0A2K6P9K1
names: Subcellular Location Annotation
messages: Membrane

61622:TMEM234
gene id: 61622:TMEM234
uniprot id: A0A2K6P6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

61622:DOLPP1
gene id: 61622:DOLPP1
uniprot id: A0A2K6R3U2
uniprot id: A0A2K6R3V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.

61622:DUSP3
gene id: 61622:DUSP3
uniprot id: A0A2K6PW96
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

61622:C7
gene id: 61622:C7
uniprot id: A0A2K6QZQ9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:REV3L
gene id: 61622:REV3L
uniprot id: A0A2K6P9X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

61622:JPH4
gene id: 61622:JPH4
uniprot id: A0A2K6R218
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

61622:LOC104670107
gene id: 61622:LOC104670107
uniprot id: A0A2K6NCL0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:ACOX1
gene id: 61622:ACOX1
uniprot id: A0A2K6NNS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61622:LOC104656604
gene id: 61622:LOC104656604
uniprot id: A0A2K6RRE4
uniprot id: A0A2K6RRF1
names: Similarity
messages: Belongs to the Luc7 family.

61622:SV2C
gene id: 61622:SV2C
uniprot id: A0A2K6NGL7
names: Subcellular Location Annotation
messages: synaptic vesicle membrane

61622:PDIA2
gene id: 61622:PDIA2
uniprot id: A0A2K6N957
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

61622:KAT5
gene id: 61622:KAT5
uniprot id: A0A2K6RDA6
uniprot id: A0A2K6RDD8
uniprot id: A0A2K6RDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

61622:CAPZA2
gene id: 61622:CAPZA2
uniprot id: A0A2K6NAY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

61622:ANKZF1
gene id: 61622:ANKZF1
uniprot id: A0A2K6Q2F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

61622:TMEM19
gene id: 61622:TMEM19
uniprot id: A0A2K6NK65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

61622:NXPH4
gene id: 61622:NXPH4
uniprot id: A0A2K6NSJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

61622:LRRC8E
gene id: 61622:LRRC8E
uniprot id: A0A2K6QZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

61622:MOGS
gene id: 61622:MOGS
uniprot id: A0A2K6N954
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

61622:KCNJ5
gene id: 61622:KCNJ5
uniprot id: A0A2K6R7C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

61622:RFTN1
gene id: 61622:RFTN1
uniprot id: A0A2K6PAZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

61622:NOSIP
gene id: 61622:NOSIP
uniprot id: A0A2K6P7S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Cytoplasm
messages: Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
messages: Nucleus

61622:POU2F2
gene id: 61622:POU2F2
uniprot id: A0A2K6QQI1
uniprot id: A0A2K6QQJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

61622:GLO1
gene id: 61622:GLO1
uniprot id: A0A2K6QB47
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

61622:WIPI2
gene id: 61622:WIPI2
uniprot id: A0A2K6QIE8
uniprot id: A0A2K6QIG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure membrane

61622:EME1
gene id: 61622:EME1
uniprot id: A0A2K6RWQ2
names: Similarity
messages: Belongs to the EME1/MMS4 family.

61622:EIF1AD
gene id: 61622:EIF1AD
uniprot id: A0A2K6RTE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

61622:ADRB2
gene id: 61622:ADRB2
uniprot id: A0A2K6NNH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
messages: Cell membrane
messages: Early endosome
messages: Golgi apparatus
messages: Membrane

61622:RALB
gene id: 61622:RALB
uniprot id: A0A2K6NHU2
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

61622:SLC7A10
gene id: 61622:SLC7A10
uniprot id: A0A2K6QJM1
names: Subcellular Location Annotation
messages: Membrane

61622:TSFM
gene id: 61622:TSFM
uniprot id: A0A2K6PF73
uniprot id: A0A2K6PF87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Mitochondrion

61622:ACTL7B
gene id: 61622:ACTL7B
uniprot id: A0A2K6ND29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

61622:CYSTM1
gene id: 61622:CYSTM1
uniprot id: A0A2K6QAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

61622:SPOPL
gene id: 61622:SPOPL
uniprot id: A0A2K6RH72
names: Similarity
messages: Belongs to the Tdpoz family.

61622:SLC2A6
gene id: 61622:SLC2A6
uniprot id: A0A2K6QN88
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:HS3ST1
gene id: 61622:HS3ST1
uniprot id: A0A2K6NBT9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:UBE2K
gene id: 61622:UBE2K
uniprot id: A0A2K6PAJ0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:NRDC
gene id: 61622:NRDC
uniprot id: A0A2K6Q0M4
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:ZDHHC22
gene id: 61622:ZDHHC22
uniprot id: A0A2K6P8M0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:ZSCAN2
gene id: 61622:ZSCAN2
uniprot id: A0A2K6QQT2
names: Subcellular Location Annotation
messages: Nucleus

61622:NAA11
gene id: 61622:NAA11
uniprot id: A0A2K6NUW4
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

61622:BABAM2
gene id: 61622:BABAM2
uniprot id: A0A2K6Q0Z4
uniprot id: A0A2K6Q100
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BABAM2 family.
messages: Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.
messages: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
messages: Cytoplasm
messages: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
messages: Nucleus

61622:THAP1
gene id: 61622:THAP1
uniprot id: A0A2K6R8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

61622:LOC104681098
gene id: 61622:LOC104681098
uniprot id: A0A2K6NPJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:GDPD5
gene id: 61622:GDPD5
uniprot id: A0A2K6PHA8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:FAM167A
gene id: 61622:FAM167A
uniprot id: A0A2K6QAH2
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

61622:ANAPC10
gene id: 61622:ANAPC10
uniprot id: A0A2K6NM97
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

61622:ANP32B
gene id: 61622:ANP32B
uniprot id: A0A2K6Q8J8
names: Similarity
messages: Belongs to the ANP32 family.

61622:LOC104678132
gene id: 61622:LOC104678132
uniprot id: A0A2K6NLX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CETN1
gene id: 61622:CETN1
uniprot id: A0A2K6NM19
names: Similarity
messages: Belongs to the centrin family.

61622:OXER1
gene id: 61622:OXER1
uniprot id: A0A2K6NHF5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:ZDHHC14
gene id: 61622:ZDHHC14
uniprot id: A0A2K6QHF8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:PMVK
gene id: 61622:PMVK
uniprot id: A0A2K6QA77
names: Subcellular Location Annotation
messages: cytosol

61622:HARS2
gene id: 61622:HARS2
uniprot id: A0A2K6Q8Y7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:DLGAP5
gene id: 61622:DLGAP5
uniprot id: A0A2K6Q7Z9
uniprot id: A0A2K6Q811
names: Similarity
messages: Belongs to the SAPAP family.

61622:SNRPD2
gene id: 61622:SNRPD2
uniprot id: A0A2K6PYX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
messages: cytosol

61622:PRKAR1A
gene id: 61622:PRKAR1A
uniprot id: A0A2K6QAI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61622:SH2B1
gene id: 61622:SH2B1
uniprot id: A0A2K6NYR6
names: Similarity
messages: Belongs to the SH2B adapter family.

61622:HJV
gene id: 61622:HJV
uniprot id: A0A2K6QT76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

61622:HCN3
gene id: 61622:HCN3
uniprot id: A0A2K6R2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

61622:GMNN
gene id: 61622:GMNN
uniprot id: A0A2K6QSH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

61622:HMGCS1
gene id: 61622:HMGCS1
uniprot id: A0A2K6RIH9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

61622:CSGALNACT1
gene id: 61622:CSGALNACT1
uniprot id: A0A2K6P7A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

61622:ACKR4
gene id: 61622:ACKR4
uniprot id: A0A2K6NUN0
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:GET1
gene id: 61622:GET1
uniprot id: A0A2K6QMC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:VEGFD
gene id: 61622:VEGFD
uniprot id: A0A2K6P1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

61622:CSRNP2
gene id: 61622:CSRNP2
uniprot id: A0A2K6QZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

61622:LBR
gene id: 61622:LBR
uniprot id: A0A2K6QZG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

61622:CNOT1
gene id: 61622:CNOT1
uniprot id: A0A2K6N8Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

61622:C11H10orf90
gene id: 61622:C11H10orf90
uniprot id: A0A2K6PHM5
names: Subcellular Location Annotation
messages: centrosome

61622:ELOC
gene id: 61622:ELOC
uniprot id: A0A2K6PBR9
names: Similarity
messages: Belongs to the SKP1 family.

61622:EIF2D
gene id: 61622:EIF2D
uniprot id: A0A2K6PV60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF2D family.
messages: Cytoplasm
messages: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

61622:NOL12
gene id: 61622:NOL12
uniprot id: A0A2K6QHK0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

61622:MVD
gene id: 61622:MVD
uniprot id: A0A2K6PZ43
names: Function
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.
messages: Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis.

61622:ATP2A1
gene id: 61622:ATP2A1
uniprot id: A0A2K6NHM8
uniprot id: A0A2K6NHN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61622:MMGT1
gene id: 61622:MMGT1
uniprot id: A0A2K6RIB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

61622:ZDHHC6
gene id: 61622:ZDHHC6
uniprot id: A0A2K6NXR7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:LOC104669754
gene id: 61622:LOC104669754
uniprot id: A0A2K6QRX9
names: Subcellular Location Annotation
messages: Nucleus

61622:THBS2
gene id: 61622:THBS2
uniprot id: A0A2K6QLW7
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:UNC93A
gene id: 61622:UNC93A
uniprot id: A0A2K6NBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

61622:ZNF330
gene id: 61622:ZNF330
uniprot id: A0A2K6Q8B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOA36 family.
messages: nucleolus

61622:RECQL5
gene id: 61622:RECQL5
uniprot id: A0A2K6RG98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

61622:GDNF
gene id: 61622:GDNF
uniprot id: A0A2K6RM80
uniprot id: A0A2K6RM89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

61622:PISD
gene id: 61622:PISD
uniprot id: A0A2K6PXH4
uniprot id: A0A2K6PXI2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

61622:TXLNB
gene id: 61622:TXLNB
uniprot id: A0A2K6Q7C5
names: Similarity
messages: Belongs to the taxilin family.

61622:BAK1
gene id: 61622:BAK1
uniprot id: A0A2K6N8B6
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:TADA2A
gene id: 61622:TADA2A
uniprot id: A0A2K6RFE7
names: Subcellular Location Annotation
messages: Nucleus

61622:RAD50
gene id: 61622:RAD50
uniprot id: A0A2K6QKN3
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

61622:MRPL4
gene id: 61622:MRPL4
uniprot id: A0A2K6NA21
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

61622:LOC104658862
gene id: 61622:LOC104658862
uniprot id: A0A2K6PZK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

61622:TIGD4
gene id: 61622:TIGD4
uniprot id: A0A2K6NL06
names: Subcellular Location Annotation
messages: Nucleus

61622:SMAD7
gene id: 61622:SMAD7
uniprot id: A0A2K6RHH7
names: Subcellular Location Annotation
messages: Nucleus

61622:RAD9B
gene id: 61622:RAD9B
uniprot id: A0A2K6P125
uniprot id: A0A2K6P134
names: Similarity
messages: Belongs to the rad9 family.

61622:NKX6-3
gene id: 61622:NKX6-3
uniprot id: A0A2K6NSQ1
names: Subcellular Location Annotation
messages: Nucleus

61622:EME2
gene id: 61622:EME2
uniprot id: A0A2K6RKP2
names: Similarity
messages: Belongs to the EME1/MMS4 family.

61622:DPYS
gene id: 61622:DPYS
uniprot id: A0A2K6P7Y8
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

61622:CDH7
gene id: 61622:CDH7
uniprot id: A0A2K6RV23
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:ERLEC1
gene id: 61622:ERLEC1
uniprot id: A0A2K6R8W3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

61622:TMPRSS11B
gene id: 61622:TMPRSS11B
uniprot id: A0A2K6PBD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61622:TMOD3
gene id: 61622:TMOD3
uniprot id: A0A2K6REL6
names: Subcellular Location Annotation
messages: cytoskeleton

61622:NOG
gene id: 61622:NOG
uniprot id: A0A2K6NIW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

61622:NDUFS2
gene id: 61622:NDUFS2
uniprot id: A0A2K6PJD6
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

61622:FAM187B
gene id: 61622:FAM187B
uniprot id: A0A2K6NN24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

61622:KIF13A
gene id: 61622:KIF13A
uniprot id: A0A2K6QPW1
names: Caution
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SEMA3C
gene id: 61622:SEMA3C
uniprot id: A0A2K6RK06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:USO1
gene id: 61622:USO1
uniprot id: A0A2K6PC75
uniprot id: A0A2K6PCB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

61622:KCNC2
gene id: 61622:KCNC2
uniprot id: A0A2K6NXB0
uniprot id: A0A2K6NXB7
uniprot id: A0A2K6NXB8
uniprot id: A0A2K6NXC1
uniprot id: A0A2K6NXC4
uniprot id: A0A2K6NXC5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SLC5A6
gene id: 61622:SLC5A6
uniprot id: A0A2K6NFM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:LOC104660034
gene id: 61622:LOC104660034
uniprot id: A0A2K6QDG5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:HS3ST3A1
gene id: 61622:HS3ST3A1
uniprot id: A0A2K6Q0C4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:NMD3
gene id: 61622:NMD3
uniprot id: A0A2K6Q7M9
uniprot id: A0A2K6Q7N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

61622:MRPS18C
gene id: 61622:MRPS18C
uniprot id: A0A2K6RMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Mitochondrion

61622:ETNPPL
gene id: 61622:ETNPPL
uniprot id: A0A2K6NYV1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

61622:BORCS5
gene id: 61622:BORCS5
uniprot id: A0A2K6RUT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS5 family.
messages: Lysosome membrane
messages: Membrane

61622:HSPA9
gene id: 61622:HSPA9
uniprot id: A0A2K6Q1W7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61622:AQP2
gene id: 61622:AQP2
uniprot id: A0A2K6NAA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:ACAD11
gene id: 61622:ACAD11
uniprot id: A0A2K6RIX8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:MS4A7
gene id: 61622:MS4A7
uniprot id: A0A2K6P136
names: Similarity
messages: Belongs to the MS4A family.

61622:PPARD
gene id: 61622:PPARD
uniprot id: A0A2K6NYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:ASF1B
gene id: 61622:ASF1B
uniprot id: A0A2K6PJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

61622:STK38
gene id: 61622:STK38
uniprot id: A0A2K6PX49
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:ESX1
gene id: 61622:ESX1
uniprot id: A0A2K6NUG1
names: Subcellular Location Annotation
messages: Nucleus

61622:PIP4P1
gene id: 61622:PIP4P1
uniprot id: A0A2K6PCT4
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

61622:MOSPD1
gene id: 61622:MOSPD1
uniprot id: A0A2K6NGX7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

61622:EPN3
gene id: 61622:EPN3
uniprot id: A0A2K6RD74
names: Similarity
messages: Belongs to the epsin family.

61622:CASP5
gene id: 61622:CASP5
uniprot id: A0A2K6P236
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:ARSI
gene id: 61622:ARSI
uniprot id: A0A2K6RFA4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:LOC104670048
gene id: 61622:LOC104670048
uniprot id: A0A2K6RKL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:MRPS24
gene id: 61622:MRPS24
uniprot id: A0A2K6RFR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

61622:GALR2
gene id: 61622:GALR2
uniprot id: A0A2K6RKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:B3GNT5
gene id: 61622:B3GNT5
uniprot id: A0A2K6NCX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:TAF2
gene id: 61622:TAF2
uniprot id: A0A2K6RB22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

61622:SLC15A3
gene id: 61622:SLC15A3
uniprot id: A0A2K6NSE2
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

61622:GTPBP8
gene id: 61622:GTPBP8
uniprot id: A0A2K6NIC8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

61622:LCN10
gene id: 61622:LCN10
uniprot id: A0A2K6PNL2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:STEAP1
gene id: 61622:STEAP1
uniprot id: A0A2K6NRQ2
names: Subcellular Location Annotation
messages: Membrane

61622:SPDEF
gene id: 61622:SPDEF
uniprot id: A0A2K6P4J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:EFNA4
gene id: 61622:EFNA4
uniprot id: A0A2K6RPU2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:MEF2D
gene id: 61622:MEF2D
uniprot id: A0A2K6NBD7
uniprot id: A0A2K6NBE8
uniprot id: A0A2K6NBI9
names: Subcellular Location Annotation
messages: Nucleus

61622:LCA5
gene id: 61622:LCA5
uniprot id: A0A2K6PLP2
names: Similarity
messages: Belongs to the LCA5 family.

61622:FAM110D
gene id: 61622:FAM110D
uniprot id: A0A2K6NJU4
names: Similarity
messages: Belongs to the FAM110 family.

61622:TRAPPC2
gene id: 61622:TRAPPC2
uniprot id: A0A2K6P2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

61622:TMEM17
gene id: 61622:TMEM17
uniprot id: A0A2K6QN45
names: Subcellular Location Annotation
messages: Membrane

61622:CCDC39
gene id: 61622:CCDC39
uniprot id: A0A2K6QQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC39 family.
messages: cilium axoneme

61622:OXT
gene id: 61622:OXT
uniprot id: A0A2K6PB87
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

61622:STX7
gene id: 61622:STX7
uniprot id: A0A2K6NZI5
names: Similarity
messages: Belongs to the syntaxin family.

61622:SPECC1L
gene id: 61622:SPECC1L
uniprot id: A0A2K6QT29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

61622:COL4A6
gene id: 61622:COL4A6
uniprot id: A0A2K6RKZ6
uniprot id: A0A2K6RKZ8
uniprot id: A0A2K6RL03
uniprot id: A0A2K6RL05
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:NEXMIF
gene id: 61622:NEXMIF
uniprot id: A0A2K6RGS0
names: Subcellular Location Annotation
messages: Nucleus

61622:RABGGTA
gene id: 61622:RABGGTA
uniprot id: A0A2K6RL64
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

61622:NDRG2
gene id: 61622:NDRG2
uniprot id: A0A2K6PGW2
uniprot id: A0A2K6PGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm
messages: growth cone

61622:CRELD2
gene id: 61622:CRELD2
uniprot id: A0A2K6PHE0
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PPM1G
gene id: 61622:PPM1G
uniprot id: A0A2K6R3Z8
names: Similarity
messages: Belongs to the PP2C family.

61622:RPA3
gene id: 61622:RPA3
uniprot id: A0A2K6QE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

61622:WARS1
gene id: 61622:WARS1
uniprot id: A0A2K6NLL2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:IARS2
gene id: 61622:IARS2
uniprot id: A0A2K6NGE6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:MIEF2
gene id: 61622:MIEF2
uniprot id: A0A2K6QN70
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

61622:ATP5MG
gene id: 61622:ATP5MG
uniprot id: A0A2K6NNI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

61622:TUBG2
gene id: 61622:TUBG2
uniprot id: A0A2K6PDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

61622:NAT9
gene id: 61622:NAT9
uniprot id: A0A2K6NM18
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

61622:CPEB4
gene id: 61622:CPEB4
uniprot id: A0A2K6NZ37
uniprot id: A0A2K6NZ38
names: Similarity
messages: Belongs to the RRM CPEB family.

61622:CCL17
gene id: 61622:CCL17
uniprot id: A0A2K6PBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:PORCN
gene id: 61622:PORCN
uniprot id: A0A2K6PZJ0
uniprot id: A0A2K6PZK7
names: Subcellular Location Annotation
messages: Membrane

61622:UBE2T
gene id: 61622:UBE2T
uniprot id: A0A2K6QDU6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:MAPK14
gene id: 61622:MAPK14
uniprot id: A0A2K6QA65
uniprot id: A0A2K6QA67
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

61622:SIX4
gene id: 61622:SIX4
uniprot id: A0A2K6NH49
uniprot id: A0A2K6NH58
names: Subcellular Location Annotation
messages: Nucleus

61622:MMUT
gene id: 61622:MMUT
uniprot id: A0A2K6NQD7
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

61622:CCR9
gene id: 61622:CCR9
uniprot id: A0A2K6QI53
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:PSMA2
gene id: 61622:PSMA2
uniprot id: A0A2K6PDA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:KITLG
gene id: 61622:KITLG
uniprot id: A0A2K6Q660
uniprot id: A0A2K6Q674
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCF family.
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: filopodium
messages: lamellipodium

61622:MINAR2
gene id: 61622:MINAR2
uniprot id: A0A2K6NZQ8
names: Similarity
messages: Belongs to the MINAR family.

61622:MSH5
gene id: 61622:MSH5
uniprot id: A0A2K6PPS2
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

61622:FAM120A
gene id: 61622:FAM120A
uniprot id: A0A2K6NV55
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

61622:EBF2
gene id: 61622:EBF2
uniprot id: A0A2K6PZ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

61622:RGS1
gene id: 61622:RGS1
uniprot id: A0A2K6P5S5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

61622:FLOT2
gene id: 61622:FLOT2
uniprot id: A0A2K6PCK1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.
messages: Cell membrane
messages: Endosome
messages: Heterooligomeric complex.
messages: Membrane
messages: caveola

61622:LGI3
gene id: 61622:LGI3
uniprot id: A0A2K6PF33
names: Subcellular Location Annotation
messages: Secreted

61622:RPL24
gene id: 61622:RPL24
uniprot id: A0A2K6RVF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61622:AK4
gene id: 61622:AK4
uniprot id: A0A2K6QAK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

61622:LOC104663490
gene id: 61622:LOC104663490
uniprot id: A0A2K6NJG1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:DEFB124
gene id: 61622:DEFB124
uniprot id: A0A2K6P6X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:LOC104662340
gene id: 61622:LOC104662340
uniprot id: A0A2K6P3G0
names: Similarity
messages: Belongs to the globin family.

61622:SSTR3
gene id: 61622:SSTR3
uniprot id: A0A2K6NPE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:YPEL3
gene id: 61622:YPEL3
uniprot id: A0A2K6NBQ9
names: Similarity
messages: Belongs to the yippee family.

61622:CENPN
gene id: 61622:CENPN
uniprot id: A0A2K6NBU9
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

61622:LOC104656380
gene id: 61622:LOC104656380
uniprot id: A0A2K6NNY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CCR4
gene id: 61622:CCR4
uniprot id: A0A2K6NQC3
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:COG1
gene id: 61622:COG1
uniprot id: A0A2K6NPF1
names: Similarity
messages: Belongs to the COG1 family.

61622:OTULIN
gene id: 61622:OTULIN
uniprot id: A0A2K6NWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

61622:LOC104654355
gene id: 61622:LOC104654355
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:CSTF1
gene id: 61622:CSTF1
uniprot id: A0A2K6NBP7
names: Subcellular Location Annotation
messages: Nucleus

61622:SELENBP1
gene id: 61622:SELENBP1
uniprot id: A0A2K6QEB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selenium-binding protein family.
messages: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.
messages: Interacts with USP33.
messages: Membrane
messages: Nucleus
messages: cytosol

61622:LOC104675519
gene id: 61622:LOC104675519
uniprot id: A0A2K6QEM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:LOC104679886
gene id: 61622:LOC104679886
uniprot id: A0A2K6N726
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

61622:NXPE2
gene id: 61622:NXPE2
uniprot id: A0A2K6R035
names: Similarity
messages: Belongs to the NXPE family.

61622:WASF2
gene id: 61622:WASF2
uniprot id: A0A2K6NG28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

61622:PGAP1
gene id: 61622:PGAP1
uniprot id: A0A2K6P888
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

61622:SMAD3
gene id: 61622:SMAD3
uniprot id: A0A2K6NPB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

61622:DSC1
gene id: 61622:DSC1
uniprot id: A0A2K6NFN0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:EDC3
gene id: 61622:EDC3
uniprot id: A0A2K6Q057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

61622:CMPK1
gene id: 61622:CMPK1
uniprot id: A0A2K6PGN7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

61622:LOC104663484
gene id: 61622:LOC104663484
uniprot id: A0A2K6NQ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:GLMP
gene id: 61622:GLMP
uniprot id: A0A2K6P4T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

61622:SDHAF2
gene id: 61622:SDHAF2
uniprot id: A0A2K6QHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

61622:EVA1B
gene id: 61622:EVA1B
uniprot id: A0A2K6PY61
names: Similarity
messages: Belongs to the EVA1 family.

61622:VPS13B
gene id: 61622:VPS13B
uniprot id: A0A2K6QGQ5
uniprot id: A0A2K6QGR4
names: Similarity
messages: Belongs to the VPS13 family.

61622:KCNK17
gene id: 61622:KCNK17
uniprot id: A0A2K6NBB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:TUBG1
gene id: 61622:TUBG1
uniprot id: A0A2K6QS78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

61622:NIT1
gene id: 61622:NIT1
uniprot id: A0A2K6QEB2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

61622:TSR2
gene id: 61622:TSR2
uniprot id: A0A2K6P0K8
names: Function
names: Similarity
messages: Belongs to the TSR2 family.
messages: May be involved in 20S pre-rRNA processing.

61622:TMEM263
gene id: 61622:TMEM263
uniprot id: A0A2K6PJ44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

61622:PHKG2
gene id: 61622:PHKG2
uniprot id: A0A2K6PU67
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

61622:NFYB
gene id: 61622:NFYB
uniprot id: A0A2K6QGH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NFYB/HAP3 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
messages: Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP.

61622:SLC5A2
gene id: 61622:SLC5A2
uniprot id: A0A2K6PNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:AMT
gene id: 61622:AMT
uniprot id: A0A2K6PE29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

61622:GALR1
gene id: 61622:GALR1
uniprot id: A0A2K6NEV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:FAAH
gene id: 61622:FAAH
uniprot id: A0A2K6RDT7
names: Similarity
messages: Belongs to the amidase family.

61622:ARHGDIG
gene id: 61622:ARHGDIG
uniprot id: A0A2K6Q216
names: Similarity
messages: Belongs to the Rho GDI family.

61622:SQSTM1
gene id: 61622:SQSTM1
uniprot id: A0A2K6Q7D6
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

61622:TMX2
gene id: 61622:TMX2
uniprot id: A0A2K6PMC0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

61622:TPM4
gene id: 61622:TPM4
uniprot id: A0A2K6Q9T1
uniprot id: A0A2K6Q9U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61622:MMP27
gene id: 61622:MMP27
uniprot id: A0A2K6NCW7
names: Similarity
messages: Belongs to the peptidase M10A family.

61622:GMPR
gene id: 61622:GMPR
uniprot id: A0A2K6R131
uniprot id: A0A2K6R144
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TRIM50
gene id: 61622:TRIM50
uniprot id: A0A2K6Q9J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

61622:PHC2
gene id: 61622:PHC2
uniprot id: A0A2K6REH5
names: Subcellular Location Annotation
messages: Nucleus

61622:UCK1
gene id: 61622:UCK1
uniprot id: A0A2K6NME0
names: Similarity
messages: Belongs to the uridine kinase family.

61622:HOMER2
gene id: 61622:HOMER2
uniprot id: A0A2K6REU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

61622:TMEM45B
gene id: 61622:TMEM45B
uniprot id: A0A2K6RFG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

61622:DNM1L
gene id: 61622:DNM1L
uniprot id: A0A2K6R8V7
uniprot id: A0A2K6R8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
messages: Endomembrane system
messages: Golgi apparatus
messages: Membrane
messages: Mitochondrion outer membrane
messages: Peroxisome
messages: clathrin-coated pit
messages: cytosol
messages: synaptic vesicle membrane

61622:FH
gene id: 61622:FH
uniprot id: A0A2K6REZ2
names: Function
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.

61622:MED17
gene id: 61622:MED17
uniprot id: A0A2K6PT77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:ALX4
gene id: 61622:ALX4
uniprot id: A0A2K6P8F2
names: Subcellular Location Annotation
messages: Nucleus

61622:DDIT4L
gene id: 61622:DDIT4L
uniprot id: A0A2K6QPQ4
names: Similarity
messages: Belongs to the DDIT4 family.

61622:UBL3
gene id: 61622:UBL3
uniprot id: A0A2K6RMS2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104662102
gene id: 61622:LOC104662102
uniprot id: A0A2K6RDZ9
uniprot id: A0A2K6RE03
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:MEN1
gene id: 61622:MEN1
uniprot id: A0A2K6Q9Z2
uniprot id: A0A2K6QA00
names: Subcellular Location Annotation
messages: Nucleus

61622:SUSD5
gene id: 61622:SUSD5
uniprot id: A0A2K6Q9H4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PDHB
gene id: 61622:PDHB
uniprot id: A0A2K6NAP2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

61622:DHRS11
gene id: 61622:DHRS11
uniprot id: A0A2K6QGK6
uniprot id: A0A2K6QGL3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:NTMT1
gene id: 61622:NTMT1
uniprot id: A0A2K6RSB2
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

61622:MCM10
gene id: 61622:MCM10
uniprot id: A0A2K6RXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

61622:LOC104681778
gene id: 61622:LOC104681778
uniprot id: A0A2K6RHH4
uniprot id: A0A2K6RHH8
uniprot id: A0A2K6RHI4
uniprot id: A0A2K6RHI8
uniprot id: A0A2K6RHJ7
uniprot id: A0A2K6RHL7
uniprot id: A0A2K6RHL9
uniprot id: A0A2K6RHN1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

61622:EIF2B5
gene id: 61622:EIF2B5
uniprot id: A0A2K6QFL0
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

61622:EMX2
gene id: 61622:EMX2
uniprot id: A0A2K6RWM0
names: Subcellular Location Annotation
messages: Nucleus

61622:SNRPA
gene id: 61622:SNRPA
uniprot id: A0A2K6RCF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM U1 A/B'' family.
messages: Nucleus

61622:INTS12
gene id: 61622:INTS12
uniprot id: A0A2K6Q2M2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Integrator subunit 12 family.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

61622:PTP4A2
gene id: 61622:PTP4A2
uniprot id: A0A2K6P7K9
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61622:PSMA1
gene id: 61622:PSMA1
uniprot id: A0A2K6QGL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:KIZ
gene id: 61622:KIZ
uniprot id: A0A2K6P8Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

61622:TTC21B
gene id: 61622:TTC21B
uniprot id: A0A2K6PK51
names: Similarity
messages: Belongs to the TTC21 family.

61622:LDHD
gene id: 61622:LDHD
uniprot id: A0A2K6R178
uniprot id: A0A2K6R182
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

61622:MYADM
gene id: 61622:MYADM
uniprot id: A0A2K6NR39
names: Subcellular Location Annotation
messages: Membrane

61622:CD164
gene id: 61622:CD164
uniprot id: A0A2K6QCC3
uniprot id: A0A2K6QCD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

61622:DNAJA2
gene id: 61622:DNAJA2
uniprot id: A0A2K6R3H1
names: Subcellular Location Annotation
messages: Membrane

61622:COPZ2
gene id: 61622:COPZ2
uniprot id: A0A2K6PA98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

61622:TSPAN16
gene id: 61622:TSPAN16
uniprot id: A0A2K6RRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:EXOSC5
gene id: 61622:EXOSC5
uniprot id: A0A2K6RKX0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:FICD
gene id: 61622:FICD
uniprot id: A0A2K6P971
names: Similarity
messages: Belongs to the fic family.

61622:GOLT1B
gene id: 61622:GOLT1B
uniprot id: A0A2K6NEJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

61622:SERPINA10
gene id: 61622:SERPINA10
uniprot id: A0A2K6RGA8
names: Similarity
messages: Belongs to the serpin family.

61622:BET1L
gene id: 61622:BET1L
uniprot id: A0A2K6NWD0
names: Subcellular Location Annotation
messages: Membrane

61622:SSR4
gene id: 61622:SSR4
uniprot id: A0A2K6Q489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-delta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

61622:KANSL2
gene id: 61622:KANSL2
uniprot id: A0A2K6NUS1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus

61622:INO80C
gene id: 61622:INO80C
uniprot id: A0A2K6P8J0
names: Subcellular Location Annotation
messages: Nucleus

61622:PPP5C
gene id: 61622:PPP5C
uniprot id: A0A2K6NSR5
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

61622:GFRAL
gene id: 61622:GFRAL
uniprot id: A0A2K6P355
names: Similarity
messages: Belongs to the GDNFR family.

61622:PATJ
gene id: 61622:PATJ
uniprot id: A0A2K6NF26
uniprot id: A0A2K6NF27
names: Subcellular Location Annotation
messages: tight junction

61622:VAMP4
gene id: 61622:VAMP4
uniprot id: A0A2K6Q965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61622:LOC104672001
gene id: 61622:LOC104672001
uniprot id: A0A2K6N778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

61622:NHP2
gene id: 61622:NHP2
uniprot id: A0A2K6RGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

61622:PRSS12
gene id: 61622:PRSS12
uniprot id: A0A2K6PP32
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
messages: Secreted

61622:FZD4
gene id: 61622:FZD4
uniprot id: A0A2K6NDB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

61622:SAR1B
gene id: 61622:SAR1B
uniprot id: A0A2K6NX08
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

61622:ZNF408
gene id: 61622:ZNF408
uniprot id: A0A2K6PTK8
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104666489
gene id: 61622:LOC104666489
uniprot id: A0A2K6QU79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ERCC1
gene id: 61622:ERCC1
uniprot id: A0A2K6RJZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

61622:LMF2
gene id: 61622:LMF2
uniprot id: A0A2K6NRX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

61622:MFSD3
gene id: 61622:MFSD3
uniprot id: A0A2K6PXN6
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104668317
gene id: 61622:LOC104668317
uniprot id: A0A2K6PC74
names: Similarity
messages: Belongs to the FAM90 family.

61622:MAPT
gene id: 61622:MAPT
uniprot id: A0A2K6RJQ1
uniprot id: A0A2K6RJQ9
uniprot id: A0A2K6RJS0
uniprot id: A0A2K6RJS2
uniprot id: A0A2K6RJT6
names: Subcellular Location Annotation
messages: Membrane
messages: axon
messages: cytoskeleton
messages: cytosol

61622:MRPS7
gene id: 61622:MRPS7
uniprot id: A0A2K6NVB2
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

61622:HPSE2
gene id: 61622:HPSE2
uniprot id: A0A2K6RU46
uniprot id: A0A2K6RU52
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

61622:EIF1
gene id: 61622:EIF1
uniprot id: A0A2K6PMZ9
names: Similarity
messages: Belongs to the SUI1 family.

61622:IL36B
gene id: 61622:IL36B
uniprot id: A0A2K6P5B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61622:CPLX3
gene id: 61622:CPLX3
uniprot id: A0A2K6Q995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61622:DDX49
gene id: 61622:DDX49
uniprot id: A0A2K6PJD3
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:EID2
gene id: 61622:EID2
uniprot id: A0A2K6NE75
names: Subcellular Location Annotation
messages: Nucleus

61622:UBR4
gene id: 61622:UBR4
uniprot id: A0A2K6PG21
names: Similarity
messages: Belongs to the UBR4 family.

61622:NDFIP2
gene id: 61622:NDFIP2
uniprot id: A0A2K6QV02
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

61622:WLS
gene id: 61622:WLS
uniprot id: A0A2K6RSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

61622:PSEN1
gene id: 61622:PSEN1
uniprot id: A0A2K6NMU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

61622:MFAP5
gene id: 61622:MFAP5
uniprot id: A0A2K6NCV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: extracellular matrix

61622:LOC104657206
gene id: 61622:LOC104657206
uniprot id: A0A2K6N9R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CMPK2
gene id: 61622:CMPK2
uniprot id: A0A2K6NPN4
names: Similarity
messages: Belongs to the thymidylate kinase family.

61622:CDC42BPG
gene id: 61622:CDC42BPG
uniprot id: A0A2K6QVR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

61622:NSA2
gene id: 61622:NSA2
uniprot id: A0A2K6QI24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

61622:LOC104680852
gene id: 61622:LOC104680852
uniprot id: A0A2K6QEY0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

61622:BST1
gene id: 61622:BST1
uniprot id: A0A2K6ND22
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

61622:DMBX1
gene id: 61622:DMBX1
uniprot id: A0A2K6NGU9
names: Subcellular Location Annotation
messages: Nucleus

61622:CAPN10
gene id: 61622:CAPN10
uniprot id: A0A2K6R631
uniprot id: A0A2K6R637
names: Similarity
messages: Belongs to the peptidase C2 family.

61622:ATP2C1
gene id: 61622:ATP2C1
uniprot id: A0A2K6NCL5
uniprot id: A0A2K6NCP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Golgi stack membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer. Homodimer.
messages: trans-Golgi network membrane

61622:TMEM132A
gene id: 61622:TMEM132A
uniprot id: A0A2K6QQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

61622:TMEM186
gene id: 61622:TMEM186
uniprot id: A0A2K6RBS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

61622:GTF2H3
gene id: 61622:GTF2H3
uniprot id: A0A2K6P1D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
messages: Nucleus
messages: Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.

61622:METTL26
gene id: 61622:METTL26
uniprot id: A0A2K6PEK4
names: Similarity
messages: Belongs to the UPF0585 family.

61622:PAX7
gene id: 61622:PAX7
uniprot id: A0A2K6NUY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61622:MTCH1
gene id: 61622:MTCH1
uniprot id: A0A2K6RFV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:LOC104669550
gene id: 61622:LOC104669550
uniprot id: A0A2K6N9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:TM4SF20
gene id: 61622:TM4SF20
uniprot id: A0A2K6NET1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:FABP7
gene id: 61622:FABP7
uniprot id: A0A2K6R7A9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:LOC104669273
gene id: 61622:LOC104669273
uniprot id: A0A2K6PXJ1
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61622:TMEM35B
gene id: 61622:TMEM35B
uniprot id: A0A2K6R9Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

61622:KCNMB1
gene id: 61622:KCNMB1
uniprot id: A0A2K6QSK9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

61622:STAT1
gene id: 61622:STAT1
uniprot id: A0A2K6QXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61622:ELMO2
gene id: 61622:ELMO2
uniprot id: A0A2K6RHK3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

61622:TSPAN15
gene id: 61622:TSPAN15
uniprot id: A0A2K6NJ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:GPR137
gene id: 61622:GPR137
uniprot id: A0A2K6QGE4
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

61622:SEMA3F
gene id: 61622:SEMA3F
uniprot id: A0A2K6PT67
uniprot id: A0A2K6PT73
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RARRES1
gene id: 61622:RARRES1
uniprot id: A0A2K6Q9P1
names: Similarity
messages: Belongs to the protease inhibitor I47 (latexin) family.

61622:CCND2
gene id: 61622:CCND2
uniprot id: A0A2K6Q182
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

61622:IL5RA
gene id: 61622:IL5RA
uniprot id: A0A2K6PU38
uniprot id: A0A2K6PU43
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 5 subfamily.

61622:S100A5
gene id: 61622:S100A5
uniprot id: A0A2K6Q2G5
names: Similarity
messages: Belongs to the S-100 family.

61622:NXF3
gene id: 61622:NXF3
uniprot id: A0A2K6PDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm

61622:STRIP2
gene id: 61622:STRIP2
uniprot id: A0A2K6NPA8
names: Similarity
messages: Belongs to the STRIP family.

61622:TMEM47
gene id: 61622:TMEM47
uniprot id: A0A2K6RBB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

61622:QTRT1
gene id: 61622:QTRT1
uniprot id: A0A2K6QA99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

61622:OPN5
gene id: 61622:OPN5
uniprot id: A0A2K6R8Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:SERPINA7
gene id: 61622:SERPINA7
uniprot id: A0A2K6Q1V9
names: Similarity
messages: Belongs to the serpin family.

61622:SFN
gene id: 61622:SFN
uniprot id: A0A2K6N9G8
names: Similarity
messages: Belongs to the 14-3-3 family.

61622:SBK3
gene id: 61622:SBK3
uniprot id: A0A2K6Q3L0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:GFAP
gene id: 61622:GFAP
uniprot id: A0A2K6PZ80
uniprot id: A0A2K6PZA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the intermediate filament family.
messages: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
messages: Interacts with SYNM.

61622:PRKRA
gene id: 61622:PRKRA
uniprot id: A0A2K6Q2R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRKRA family.
messages: perinuclear region

61622:IFT57
gene id: 61622:IFT57
uniprot id: A0A2K6QL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

61622:LOC104659363
gene id: 61622:LOC104659363
uniprot id: A0A2K6NFY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

61622:SLC7A3
gene id: 61622:SLC7A3
uniprot id: A0A2K6NWF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

61622:NECAP1
gene id: 61622:NECAP1
uniprot id: A0A2K6RGV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

61622:ALDH1B1
gene id: 61622:ALDH1B1
uniprot id: A0A2K6NEH7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:DACT2
gene id: 61622:DACT2
uniprot id: A0A2K6PH15
names: Similarity
messages: Belongs to the dapper family.

61622:ITIH1
gene id: 61622:ITIH1
uniprot id: A0A2K6P7H9
uniprot id: A0A2K6P7I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:HOPX
gene id: 61622:HOPX
uniprot id: A0A2K6P7Y0
names: Subcellular Location Annotation
messages: Nucleus

61622:PATL1
gene id: 61622:PATL1
uniprot id: A0A2K6PLZ2
names: Similarity
messages: Belongs to the PAT1 family.

61622:FGF16
gene id: 61622:FGF16
uniprot id: A0A2K6NHB2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:DDX5
gene id: 61622:DDX5
uniprot id: A0A2K6N741
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

61622:TMEM88
gene id: 61622:TMEM88
uniprot id: A0A2K6RHL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

61622:LOC104672858
gene id: 61622:LOC104672858
uniprot id: A0A2K6NGL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:ITGB6
gene id: 61622:ITGB6
uniprot id: A0A2K6RPN7
uniprot id: A0A2K6RPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61622:TRPM1
gene id: 61622:TRPM1
uniprot id: A0A2K6PFE1
names: Subcellular Location Annotation
messages: Membrane

61622:HMOX2
gene id: 61622:HMOX2
uniprot id: A0A2K6N8F6
names: Similarity
messages: Belongs to the heme oxygenase family.

61622:ABCG2
gene id: 61622:ABCG2
uniprot id: A0A2K6NV86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion membrane

61622:DNAJC24
gene id: 61622:DNAJC24
uniprot id: A0A2K6PNB4
names: Similarity
messages: Belongs to the DPH4 family.

61622:MLF1
gene id: 61622:MLF1
uniprot id: A0A2K6N7C9
uniprot id: A0A2K6N7D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

61622:NCK2
gene id: 61622:NCK2
uniprot id: A0A2K6NSJ1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

61622:NAT10
gene id: 61622:NAT10
uniprot id: A0A2K6NF96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with THUMPD1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

61622:ANXA6
gene id: 61622:ANXA6
uniprot id: A0A2K6NX26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

61622:POFUT2
gene id: 61622:POFUT2
uniprot id: A0A2K6QBN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 68 family.
messages: Endoplasmic reticulum

61622:CDC42BPA
gene id: 61622:CDC42BPA
uniprot id: A0A2K6NZC4
uniprot id: A0A2K6NZE7
uniprot id: A0A2K6NZF8
uniprot id: A0A2K6NZI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm
messages: lamellipodium

61622:PRDM4
gene id: 61622:PRDM4
uniprot id: A0A2K6NG29
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

61622:CLVS2
gene id: 61622:CLVS2
uniprot id: A0A2K6NE31
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

61622:WNT11
gene id: 61622:WNT11
uniprot id: A0A2K6PAX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:ZNF768
gene id: 61622:ZNF768
uniprot id: A0A2K6NTR4
names: Subcellular Location Annotation
messages: Nucleus

61622:PICALM
gene id: 61622:PICALM
uniprot id: A0A2K6RDT3
uniprot id: A0A2K6RDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

61622:TCP11L2
gene id: 61622:TCP11L2
uniprot id: A0A2K6QE91
uniprot id: A0A2K6QEC2
names: Similarity
messages: Belongs to the TCP11 family.

61622:PLAC8
gene id: 61622:PLAC8
uniprot id: A0A2K6RMH2
names: Similarity
messages: Belongs to the cornifelin family.

61622:B2M
gene id: 61622:B2M
uniprot id: A0A2K6P358
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

61622:SLC39A1
gene id: 61622:SLC39A1
uniprot id: A0A2K6QFH0
names: Subcellular Location Annotation
messages: Membrane

61622:PKP1
gene id: 61622:PKP1
uniprot id: A0A2K6PA86
names: Similarity
messages: Belongs to the beta-catenin family.

61622:TMCO1
gene id: 61622:TMCO1
uniprot id: A0A2K6PTL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

61622:SLC25A44
gene id: 61622:SLC25A44
uniprot id: A0A2K6P5D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:ME1
gene id: 61622:ME1
uniprot id: A0A2K6PP47
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

61622:STAC3
gene id: 61622:STAC3
uniprot id: A0A2K6NSY4
names: Subcellular Location Annotation
messages: sarcolemma

61622:RRP12
gene id: 61622:RRP12
uniprot id: A0A2K6PJI0
names: Similarity
messages: Belongs to the RRP12 family.

61622:DNASE2B
gene id: 61622:DNASE2B
uniprot id: A0A2K6QGZ3
names: Similarity
messages: Belongs to the DNase II family.

61622:ADAMDEC1
gene id: 61622:ADAMDEC1
uniprot id: A0A2K6NNE0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TUBB1
gene id: 61622:TUBB1
uniprot id: A0A2K6P2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61622:LOC104680718
gene id: 61622:LOC104680718
uniprot id: A0A2K6PKK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

61622:ZSCAN4
gene id: 61622:ZSCAN4
uniprot id: A0A2K6P7U3
names: Subcellular Location Annotation
messages: Nucleus

61622:HAPLN2
gene id: 61622:HAPLN2
uniprot id: A0A2K6R3P1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TSR3
gene id: 61622:TSR3
uniprot id: A0A2K6RB65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CENPO
gene id: 61622:CENPO
uniprot id: A0A2K6RCD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

61622:GPD1L
gene id: 61622:GPD1L
uniprot id: A0A2K6PL61
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

61622:RETREG1
gene id: 61622:RETREG1
uniprot id: A0A2K6PWK3
uniprot id: A0A2K6PWK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Membrane

61622:FABP9
gene id: 61622:FABP9
uniprot id: A0A2K6R079
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:LEF1
gene id: 61622:LEF1
uniprot id: A0A2K6QWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

61622:ZNF263
gene id: 61622:ZNF263
uniprot id: A0A2K6QXV8
names: Subcellular Location Annotation
messages: Nucleus

61622:TRAF6
gene id: 61622:TRAF6
uniprot id: A0A2K6RDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

61622:GAB1
gene id: 61622:GAB1
uniprot id: A0A2K6P4L2
uniprot id: A0A2K6P4N0
names: Similarity
messages: Belongs to the GAB family.

61622:KCNC4
gene id: 61622:KCNC4
uniprot id: A0A2K6RGG9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:XPO6
gene id: 61622:XPO6
uniprot id: A0A2K6RRQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus

61622:BCL2A1
gene id: 61622:BCL2A1
uniprot id: A0A2K6PHG5
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:CCDC43
gene id: 61622:CCDC43
uniprot id: A0A2K6QRP6
names: Similarity
messages: Belongs to the CCDC43 family.

61622:MTHFR
gene id: 61622:MTHFR
uniprot id: A0A2K6RU63
uniprot id: A0A2K6RU66
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

61622:DOLK
gene id: 61622:DOLK
uniprot id: A0A2K6NQA3
names: Similarity
messages: Belongs to the polyprenol kinase family.

61622:TSC22D3
gene id: 61622:TSC22D3
uniprot id: A0A2K6PZG1
uniprot id: A0A2K6PZG6
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61622:MRPL14
gene id: 61622:MRPL14
uniprot id: A0A2K6PMD1
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

61622:KLHL40
gene id: 61622:KLHL40
uniprot id: A0A2K6R3L1
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

61622:RAD23B
gene id: 61622:RAD23B
uniprot id: A0A2K6RL12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

61622:UBE2G2
gene id: 61622:UBE2G2
uniprot id: A0A2K6P0V6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:TNNI3
gene id: 61622:TNNI3
uniprot id: A0A2K6RCK6
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

61622:DOT1L
gene id: 61622:DOT1L
uniprot id: A0A2K6RSM2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Histone methyltransferase. Methylates 'Lys-79' of histone H3.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

61622:KREMEN2
gene id: 61622:KREMEN2
uniprot id: A0A2K6RFJ2
uniprot id: A0A2K6RFN1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.

61622:TMEM150C
gene id: 61622:TMEM150C
uniprot id: A0A2K6R1X2
names: Subcellular Location Annotation
messages: Membrane

61622:MMAB
gene id: 61622:MMAB
uniprot id: A0A2K6P652
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

61622:WNT9B
gene id: 61622:WNT9B
uniprot id: A0A2K6PMR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:MARCO
gene id: 61622:MARCO
uniprot id: A0A2K6PFW7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CTBS
gene id: 61622:CTBS
uniprot id: A0A2K6NTU0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

61622:FOS
gene id: 61622:FOS
uniprot id: A0A2K6QKF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Fos subfamily.
messages: cytosol

61622:CALHM4
gene id: 61622:CALHM4
uniprot id: A0A2K6P5B2
uniprot id: A0A2K6P5D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61622:EPHA7
gene id: 61622:EPHA7
uniprot id: A0A2K6PFH6
names: Subcellular Location Annotation
messages: Membrane

61622:GGNBP2
gene id: 61622:GGNBP2
uniprot id: A0A2K6RNF4
names: Function
messages: May be involved in spermatogenesis.

61622:SLC25A37
gene id: 61622:SLC25A37
uniprot id: A0A2K6NDK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:ATXN2L
gene id: 61622:ATXN2L
uniprot id: A0A2K6NVR5
names: Similarity
messages: Belongs to the ataxin-2 family.

61622:PPP4R3A
gene id: 61622:PPP4R3A
uniprot id: A0A2K6PEF6
names: Similarity
messages: Belongs to the SMEK family.

61622:KCTD17
gene id: 61622:KCTD17
uniprot id: A0A2K6QXD6
uniprot id: A0A2K6QXJ3
names: Subcellular Location Annotation
messages: Cell membrane

61622:SPTSSA
gene id: 61622:SPTSSA
uniprot id: A0A2K6PFN2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:DENR
gene id: 61622:DENR
uniprot id: A0A2K6RNP5
names: Similarity
messages: Belongs to the DENR family.

61622:NIPSNAP1
gene id: 61622:NIPSNAP1
uniprot id: A0A2K6RPG3
names: Similarity
messages: Belongs to the NipSnap family.

61622:UNC13A
gene id: 61622:UNC13A
uniprot id: A0A2K6QVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-13 family.
messages: Cytoplasm
messages: Membrane

61622:EEF1A1
gene id: 61622:EEF1A1
uniprot id: A0A2K6RQ54
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61622:NEMP2
gene id: 61622:NEMP2
uniprot id: A0A2K6RHF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

61622:VPS36
gene id: 61622:VPS36
uniprot id: A0A2K6RI85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

61622:DARS2
gene id: 61622:DARS2
uniprot id: A0A2K6NXR6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

61622:DVL2
gene id: 61622:DVL2
uniprot id: A0A2K6PSZ4
names: Similarity
messages: Belongs to the DSH family.

61622:ICAM1
gene id: 61622:ICAM1
uniprot id: A0A2K6PK83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61622:ZDHHC2
gene id: 61622:ZDHHC2
uniprot id: A0A2K6QGA7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:LOC104679834
gene id: 61622:LOC104679834
uniprot id: A0A2K6QGT6
names: Subunit
messages: Monomer.

61622:ADI1
gene id: 61622:ADI1
uniprot id: A0A2K6PE99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer. Interacts with MMP14.
messages: Nucleus

61622:CENPJ
gene id: 61622:CENPJ
uniprot id: A0A2K6R1C6
names: Similarity
messages: Belongs to the TCP10 family.

61622:PGAP3
gene id: 61622:PGAP3
uniprot id: A0A2K6QJM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Golgi apparatus membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

61622:EIF4E2
gene id: 61622:EIF4E2
uniprot id: A0A2K6RI56
uniprot id: A0A2K6RI57
uniprot id: A0A2K6RI87
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

61622:SCML4
gene id: 61622:SCML4
uniprot id: A0A2K6NSG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

61622:GFOD2
gene id: 61622:GFOD2
uniprot id: A0A2K6RBF1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

61622:RNF152
gene id: 61622:RNF152
uniprot id: A0A2K6NGX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

61622:CD79A
gene id: 61622:CD79A
uniprot id: A0A2K6QQG5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:KRT32
gene id: 61622:KRT32
uniprot id: A0A2K6Q188
names: Similarity
messages: Belongs to the intermediate filament family.

61622:ADAMTS15
gene id: 61622:ADAMTS15
uniprot id: A0A2K6QSB6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:ATP5F1D
gene id: 61622:ATP5F1D
uniprot id: A0A2K6RMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

61622:CLIC3
gene id: 61622:CLIC3
uniprot id: A0A2K6RD11
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:LOC104662710
gene id: 61622:LOC104662710
uniprot id: A0A2K6P7B5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:NSMCE1
gene id: 61622:NSMCE1
uniprot id: A0A2K6P830
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

61622:CTSL
gene id: 61622:CTSL
uniprot id: A0A2K6QK81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:CFB
gene id: 61622:CFB
uniprot id: A0A2K6PAT0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:CSE1L
gene id: 61622:CSE1L
uniprot id: A0A2K6NLU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPO2/CSE1 family.
messages: Cytoplasm

61622:MTMR6
gene id: 61622:MTMR6
uniprot id: A0A2K6P836
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61622:PF4V1
gene id: 61622:PF4V1
uniprot id: A0A2K6QSR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:CCDC90B
gene id: 61622:CCDC90B
uniprot id: A0A2K6R9F9
names: Similarity
messages: Belongs to the CCDC90 family.

61622:EIF2B1
gene id: 61622:EIF2B1
uniprot id: A0A2K6NUL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

61622:CEMIP
gene id: 61622:CEMIP
uniprot id: A0A2K6QGN9
names: Similarity
messages: Belongs to the CEMIP family.

61622:REM1
gene id: 61622:REM1
uniprot id: A0A2K6R7S0
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61622:SYNM
gene id: 61622:SYNM
uniprot id: A0A2K6QHY7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:DPP3
gene id: 61622:DPP3
uniprot id: A0A2K6RLB2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

61622:TBXT
gene id: 61622:TBXT
uniprot id: A0A2K6P2P5
uniprot id: A0A2K6P2P6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:SEMA3E
gene id: 61622:SEMA3E
uniprot id: A0A2K6Q670
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RXFP1
gene id: 61622:RXFP1
uniprot id: A0A2K6Q4A8
uniprot id: A0A2K6Q4B1
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ATP6V1G3
gene id: 61622:ATP6V1G3
uniprot id: A0A2K6PM60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:LOC104676093
gene id: 61622:LOC104676093
uniprot id: A0A2K6PTP7
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:AK2
gene id: 61622:AK2
uniprot id: A0A2K6NBW2
uniprot id: A0A2K6NBX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

61622:SNRPC
gene id: 61622:SNRPC
uniprot id: A0A2K6R3J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

61622:IL1RAP
gene id: 61622:IL1RAP
uniprot id: A0A2K6NUF5
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:RARA
gene id: 61622:RARA
uniprot id: A0A2K6PN06
uniprot id: A0A2K6PN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:TMEM41A
gene id: 61622:TMEM41A
uniprot id: A0A2K6NRF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

61622:DIPK2B
gene id: 61622:DIPK2B
uniprot id: A0A2K6R515
uniprot id: A0A2K6R519
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

61622:PAGE4
gene id: 61622:PAGE4
uniprot id: A0A2K6Q431
names: Similarity
messages: Belongs to the GAGE family.

61622:LOC104660775
gene id: 61622:LOC104660775
uniprot id: A0A2K6QT12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

61622:LOC104678043
gene id: 61622:LOC104678043
uniprot id: A0A2K6R3J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

61622:WDR82
gene id: 61622:WDR82
uniprot id: A0A2K6QDQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SWD2 family.
messages: Nucleus

61622:HSD3B7
gene id: 61622:HSD3B7
uniprot id: A0A2K6RCI1
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61622:CCL21
gene id: 61622:CCL21
uniprot id: A0A2K6PQW0
names: Subcellular Location Annotation
messages: Secreted

61622:DBNL
gene id: 61622:DBNL
uniprot id: A0A2K6R0G6
uniprot id: A0A2K6R0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABP1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Golgi apparatus membrane
messages: Perikaryon
messages: Postsynaptic density
messages: Synapse
messages: cell cortex
messages: clathrin-coated vesicle membrane
messages: cytoskeleton
messages: dendrite
messages: lamellipodium
messages: neuron projection
messages: podosome
messages: ruffle

61622:PDK4
gene id: 61622:PDK4
uniprot id: A0A2K6Q4L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:BAAT
gene id: 61622:BAAT
uniprot id: A0A2K6NJ13
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:SEC63
gene id: 61622:SEC63
uniprot id: A0A2K6Q3L4
names: Subcellular Location Annotation
messages: Membrane

61622:SENP6
gene id: 61622:SENP6
uniprot id: A0A2K6QV11
uniprot id: A0A2K6QV20
names: Similarity
messages: Belongs to the peptidase C48 family.

61622:LOC104670641
gene id: 61622:LOC104670641
uniprot id: A0A2K6PEN7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:PXMP2
gene id: 61622:PXMP2
uniprot id: A0A2K6NPT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

61622:N4BP3
gene id: 61622:N4BP3
uniprot id: A0A2K6P3V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Cytoplasmic vesicle
messages: Vesicle
messages: axon
messages: dendrite

61622:CREB5
gene id: 61622:CREB5
uniprot id: A0A2K6PLX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
messages: Binds to the cAMP response element and activates transcription.
messages: Nucleus

61622:TACR2
gene id: 61622:TACR2
uniprot id: A0A2K6QVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:C10H12orf65
gene id: 61622:C10H12orf65
uniprot id: A0A2K6PCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

61622:KPNA3
gene id: 61622:KPNA3
uniprot id: A0A2K6R1J6
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:EFNA1
gene id: 61622:EFNA1
uniprot id: A0A2K6RK82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CHST2
gene id: 61622:CHST2
uniprot id: A0A2K6NJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61622:AQP6
gene id: 61622:AQP6
uniprot id: A0A2K6NB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:CMTM8
gene id: 61622:CMTM8
uniprot id: A0A2K6NIA8
names: Subcellular Location Annotation
messages: Membrane

61622:PLEC
gene id: 61622:PLEC
uniprot id: A0A2K6NI37
uniprot id: A0A2K6NI53
uniprot id: A0A2K6NI57
uniprot id: A0A2K6NI58
uniprot id: A0A2K6NI67
uniprot id: A0A2K6NI74
uniprot id: A0A2K6NI86
uniprot id: A0A2K6NI95
uniprot id: A0A2K6NIB2
names: Subcellular Location Annotation
messages: cytoskeleton

61622:CTSE
gene id: 61622:CTSE
uniprot id: A0A2K6RLQ4
uniprot id: A0A2K6RLR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Homodimer; disulfide-linked.
messages: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
messages: Secreted

61622:UBE2B
gene id: 61622:UBE2B
uniprot id: A0A2K6R568
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:GDAP1L1
gene id: 61622:GDAP1L1
uniprot id: A0A2K6QF89
uniprot id: A0A2K6QF90
names: Similarity
messages: Belongs to the GST superfamily.

61622:RFT1
gene id: 61622:RFT1
uniprot id: A0A2K6N9D7
uniprot id: A0A2K6N9E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

61622:ARSH
gene id: 61622:ARSH
uniprot id: A0A2K6QRK3
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:YES1
gene id: 61622:YES1
uniprot id: A0A2K6PNW5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:HMGB2
gene id: 61622:HMGB2
uniprot id: A0A2K6NV24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61622:ITPKC
gene id: 61622:ITPKC
uniprot id: A0A2K6RV31
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:POLR3D
gene id: 61622:POLR3D
uniprot id: A0A2K6QE16
names: Subcellular Location Annotation
messages: Nucleus

61622:CPSF4
gene id: 61622:CPSF4
uniprot id: A0A2K6QY62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

61622:ELP2
gene id: 61622:ELP2
uniprot id: A0A2K6RU19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

61622:RO60
gene id: 61622:RO60
uniprot id: A0A2K6PWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

61622:RPL17
gene id: 61622:RPL17
uniprot id: A0A2K6NTV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61622:EFNA5
gene id: 61622:EFNA5
uniprot id: A0A2K6PUK3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FMO1
gene id: 61622:FMO1
uniprot id: A0A2K6RMJ0
uniprot id: A0A2K6RMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.

61622:ZNF503
gene id: 61622:ZNF503
uniprot id: A0A2K6Q110
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

61622:SLC25A46
gene id: 61622:SLC25A46
uniprot id: A0A2K6NV94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:HTR2A
gene id: 61622:HTR2A
uniprot id: A0A2K6NX03
uniprot id: A0A2K6NX35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

61622:RAB5IF
gene id: 61622:RAB5IF
uniprot id: A0A2K6RJE0
uniprot id: A0A2K6RJG3
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104671059
gene id: 61622:LOC104671059
uniprot id: A0A2K6NCZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:IGHMBP2
gene id: 61622:IGHMBP2
uniprot id: A0A2K6RWU7
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

61622:PRRC1
gene id: 61622:PRRC1
uniprot id: A0A2K6PNM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

61622:STARD3
gene id: 61622:STARD3
uniprot id: A0A2K6PM95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:SYCE1L
gene id: 61622:SYCE1L
uniprot id: A0A2K6PGW5
names: Similarity
messages: Belongs to the SYCE family.

61622:PLEKHO1
gene id: 61622:PLEKHO1
uniprot id: A0A2K6P183
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:YWHAG
gene id: 61622:YWHAG
uniprot id: A0A2K6PYW1
names: Similarity
messages: Belongs to the 14-3-3 family.

61622:CBFA2T2
gene id: 61622:CBFA2T2
uniprot id: A0A2K6Q2Q3
names: Similarity
messages: Belongs to the CBFA2T family.

61622:INSIG2
gene id: 61622:INSIG2
uniprot id: A0A2K6NJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

61622:MAML2
gene id: 61622:MAML2
uniprot id: A0A2K6RIZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

61622:A2ML1
gene id: 61622:A2ML1
uniprot id: A0A2K6QBG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
messages: Secreted

61622:SARM1
gene id: 61622:SARM1
uniprot id: A0A2K6PCF4
names: Similarity
messages: Belongs to the SARM1 family.

61622:GTF2H1
gene id: 61622:GTF2H1
uniprot id: A0A2K6RMF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

61622:ITIH2
gene id: 61622:ITIH2
uniprot id: A0A2K6Q168
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:GSTO1
gene id: 61622:GSTO1
uniprot id: A0A2K6PFI7
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

61622:RIBC1
gene id: 61622:RIBC1
uniprot id: A0A2K6R863
names: Similarity
messages: Belongs to the RIB43A family.

61622:SLC2A5
gene id: 61622:SLC2A5
uniprot id: A0A2K6N990
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: sarcolemma

61622:ARAP1
gene id: 61622:ARAP1
uniprot id: A0A2K6P0I9
uniprot id: A0A2K6P0J1
names: Subcellular Location Annotation
messages: Cytoplasm

61622:TNS4
gene id: 61622:TNS4
uniprot id: A0A2K6RDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

61622:E2F6
gene id: 61622:E2F6
uniprot id: A0A2K6QL67
uniprot id: A0A2K6QL78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:PPARGC1A
gene id: 61622:PPARGC1A
uniprot id: A0A2K6NE66
uniprot id: A0A2K6NE92
names: Subcellular Location Annotation
messages: PML body

61622:SERPINB13
gene id: 61622:SERPINB13
uniprot id: A0A2K6N7U6
names: Similarity
messages: Belongs to the serpin family.

61622:DCTN6
gene id: 61622:DCTN6
uniprot id: A0A2K6QMT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: cytoskeleton

61622:INSIG1
gene id: 61622:INSIG1
uniprot id: A0A2K6PLY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

61622:TUBAL3
gene id: 61622:TUBAL3
uniprot id: A0A2K6R5K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61622:NPTX2
gene id: 61622:NPTX2
uniprot id: A0A2K6QEV4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ADCYAP1R1
gene id: 61622:ADCYAP1R1
uniprot id: A0A2K6QPB5
uniprot id: A0A2K6QPB9
uniprot id: A0A2K6QPC2
names: Subcellular Location Annotation
messages: Membrane

61622:DMC1
gene id: 61622:DMC1
uniprot id: A0A2K6REC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. DMC1 subfamily.
messages: May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
messages: Nucleus

61622:LOC104670922
gene id: 61622:LOC104670922
uniprot id: A0A2K6NCZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:NRG1
gene id: 61622:NRG1
uniprot id: A0A2K6QJD6
uniprot id: A0A2K6QJD8
uniprot id: A0A2K6QJE7
uniprot id: A0A2K6QJF7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

61622:CTSH
gene id: 61622:CTSH
uniprot id: A0A2K6NTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:SLC16A1
gene id: 61622:SLC16A1
uniprot id: A0A2K6RT55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane
messages: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

61622:APOBEC1
gene id: 61622:APOBEC1
uniprot id: A0A2K6PRF1
uniprot id: A0A2K6PRF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Cytoplasm

61622:NOP16
gene id: 61622:NOP16
uniprot id: A0A2K6RJ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

61622:TNFRSF14
gene id: 61622:TNFRSF14
uniprot id: A0A2K6QC18
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NDUFB1
gene id: 61622:NDUFB1
uniprot id: A0A2K6P5U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:TGIF1
gene id: 61622:TGIF1
uniprot id: A0A2K6Q719
names: Subcellular Location Annotation
messages: Nucleus

61622:VMA21
gene id: 61622:VMA21
uniprot id: A0A2K6QGI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the V0 complex of the vacuolar ATPase (V-ATPase).
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

61622:GABARAPL2
gene id: 61622:GABARAPL2
uniprot id: A0A2K6RMA9
names: Similarity
messages: Belongs to the ATG8 family.

61622:C10H12orf57
gene id: 61622:C10H12orf57
uniprot id: A0A2K6PDN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

61622:LIN28A
gene id: 61622:LIN28A
uniprot id: A0A2K6NGV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

61622:MYSM1
gene id: 61622:MYSM1
uniprot id: A0A2K6PIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. MYSM1 subfamily.
messages: Nucleus

61622:PDLIM3
gene id: 61622:PDLIM3
uniprot id: A0A2K6P1D4
uniprot id: A0A2K6P1D5
names: Subcellular Location Annotation
messages: Z line

61622:GPT2
gene id: 61622:GPT2
uniprot id: A0A2K6RAW6
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

61622:TMEM165
gene id: 61622:TMEM165
uniprot id: A0A2K6R3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

61622:AADACL3
gene id: 61622:AADACL3
uniprot id: A0A2K6NMC7
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61622:GIMAP8
gene id: 61622:GIMAP8
uniprot id: A0A2K6R0Q0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61622:SLC35B1
gene id: 61622:SLC35B1
uniprot id: A0A2K6PWX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

61622:ARCN1
gene id: 61622:ARCN1
uniprot id: A0A2K6RKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

61622:GORASP1
gene id: 61622:GORASP1
uniprot id: A0A2K6RT81
names: Similarity
messages: Belongs to the GORASP family.

61622:SMU1
gene id: 61622:SMU1
uniprot id: A0A2K6RP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

61622:CERS6
gene id: 61622:CERS6
uniprot id: A0A2K6RKA3
uniprot id: A0A2K6RKA6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61622:FAM151A
gene id: 61622:FAM151A
uniprot id: A0A2K6P4Z4
names: Similarity
messages: Belongs to the FAM151 family.

61622:NCOR1
gene id: 61622:NCOR1
uniprot id: A0A2K6QT44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-CoR nuclear receptor corepressors family.
messages: Nucleus

61622:TMEM167B
gene id: 61622:TMEM167B
uniprot id: A0A2K6RN13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GABRR2
gene id: 61622:GABRR2
uniprot id: A0A2K6Q6Z5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:CTSV
gene id: 61622:CTSV
uniprot id: A0A2K6Q357
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:BIRC7
gene id: 61622:BIRC7
uniprot id: A0A2K6QST0
names: Similarity
messages: Belongs to the IAP family.

61622:SNX18
gene id: 61622:SNX18
uniprot id: A0A2K6QHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

61622:LOXL4
gene id: 61622:LOXL4
uniprot id: A0A2K6NN46
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

61622:EXOC6
gene id: 61622:EXOC6
uniprot id: A0A2K6RF49
uniprot id: A0A2K6RF98
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61622:SLC22A2
gene id: 61622:SLC22A2
uniprot id: A0A2K6QJY5
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

61622:OTUD7B
gene id: 61622:OTUD7B
uniprot id: A0A2K6NGK2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CCL13
gene id: 61622:CCL13
uniprot id: A0A2K6R776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:CLDN1
gene id: 61622:CLDN1
uniprot id: A0A2K6R3U9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:SIX2
gene id: 61622:SIX2
uniprot id: A0A2K6RFY1
names: Subcellular Location Annotation
messages: Nucleus

61622:DLL3
gene id: 61622:DLL3
uniprot id: A0A2K6Q9H0
uniprot id: A0A2K6Q9I2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:RIPOR1
gene id: 61622:RIPOR1
uniprot id: A0A2K6PBE4
names: Similarity
messages: Belongs to the RIPOR family.

61622:PER1
gene id: 61622:PER1
uniprot id: A0A2K6PL09
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:DTX2
gene id: 61622:DTX2
uniprot id: A0A2K6NR95
uniprot id: A0A2K6NRB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61622:UGCG
gene id: 61622:UGCG
uniprot id: A0A2K6Q860
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

61622:C15H11orf87
gene id: 61622:C15H11orf87
uniprot id: A0A2K6NI11
names: Subcellular Location Annotation
messages: Membrane

61622:SLCO5A1
gene id: 61622:SLCO5A1
uniprot id: A0A2K6NEP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:DCLRE1B
gene id: 61622:DCLRE1B
uniprot id: A0A2K6QP32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

61622:CHAC2
gene id: 61622:CHAC2
uniprot id: A0A2K6RL23
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

61622:SDHD
gene id: 61622:SDHD
uniprot id: A0A2K6Q459
uniprot id: A0A2K6Q465
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

61622:TONSL
gene id: 61622:TONSL
uniprot id: A0A2K6QC64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

61622:MRPL32
gene id: 61622:MRPL32
uniprot id: A0A2K6QDJ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

61622:POLA2
gene id: 61622:POLA2
uniprot id: A0A2K6NHC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

61622:SLC10A2
gene id: 61622:SLC10A2
uniprot id: A0A2K6R1M0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

61622:NPM3
gene id: 61622:NPM3
uniprot id: A0A2K6P3J8
names: Similarity
messages: Belongs to the nucleoplasmin family.

61622:SF3A2
gene id: 61622:SF3A2
uniprot id: A0A2K6PWX6
names: Similarity
messages: Belongs to the SF3A2 family.

61622:HYLS1
gene id: 61622:HYLS1
uniprot id: A0A2K6NUZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

61622:CHURC1
gene id: 61622:CHURC1
uniprot id: A0A2K6QP38
names: Similarity
messages: Belongs to the Churchill family.

61622:NEFH
gene id: 61622:NEFH
uniprot id: A0A2K6R190
names: Similarity
messages: Belongs to the intermediate filament family.

61622:TLCD1
gene id: 61622:TLCD1
uniprot id: A0A2K6RPF7
uniprot id: A0A2K6RPF8
names: Subcellular Location Annotation
messages: Membrane

61622:NR2F2
gene id: 61622:NR2F2
uniprot id: A0A2K6RWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:LOC104675640
gene id: 61622:LOC104675640
uniprot id: A0A2K6QRN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body

61622:GSTO2
gene id: 61622:GSTO2
uniprot id: A0A2K6Q914
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

61622:LTBR
gene id: 61622:LTBR
uniprot id: A0A2K6R6P4
uniprot id: A0A2K6R6P9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:H1-4
gene id: 61622:H1-4
uniprot id: A0A2K6NP62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61622:PARP2
gene id: 61622:PARP2
uniprot id: A0A2K6QAT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

61622:BPGM
gene id: 61622:BPGM
uniprot id: A0A2K6QUE4
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:SLC39A11
gene id: 61622:SLC39A11
uniprot id: A0A2K6PKV3
names: Subcellular Location Annotation
messages: Membrane

61622:STAG1
gene id: 61622:STAG1
uniprot id: A0A2K6PWJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

61622:LOC104680295
gene id: 61622:LOC104680295
uniprot id: A0A2K6NED8
names: Similarity
messages: Belongs to the NDK family.

61622:QTRT2
gene id: 61622:QTRT2
uniprot id: A0A2K6PXH6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

61622:AKAP5
gene id: 61622:AKAP5
uniprot id: A0A2K6NKS3
names: Subcellular Location Annotation
messages: Membrane

61622:GBA2
gene id: 61622:GBA2
uniprot id: A0A2K6PRS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

61622:HGF
gene id: 61622:HGF
uniprot id: A0A2K6NWB3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

61622:SCIN
gene id: 61622:SCIN
uniprot id: A0A2K6PAP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: cytoskeleton
messages: podosome

61622:PCSK2
gene id: 61622:PCSK2
uniprot id: A0A2K6NTR6
uniprot id: A0A2K6NTS8
names: Similarity
messages: Belongs to the peptidase S8 family.

61622:CHRM1
gene id: 61622:CHRM1
uniprot id: A0A2K6ND32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

61622:CNTF
gene id: 61622:CNTF
uniprot id: A0A2K6P7S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

61622:ETF1
gene id: 61622:ETF1
uniprot id: A0A2K6RGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

61622:RSPO4
gene id: 61622:RSPO4
uniprot id: A0A2K6Q1X1
uniprot id: A0A2K6Q1X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

61622:ADAM8
gene id: 61622:ADAM8
uniprot id: A0A2K6QJY9
uniprot id: A0A2K6QK01
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PPP1R10
gene id: 61622:PPP1R10
uniprot id: A0A2K6Q850
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.

61622:MPP7
gene id: 61622:MPP7
uniprot id: A0A2K6PD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: adherens junction
messages: tight junction

61622:GET3
gene id: 61622:GET3
uniprot id: A0A2K6PUD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

61622:DDB1
gene id: 61622:DDB1
uniprot id: A0A2K6R4S7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

61622:ST6GAL2
gene id: 61622:ST6GAL2
uniprot id: A0A2K6QUY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Golgi stack membrane
messages: Membrane
messages: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

61622:EML6
gene id: 61622:EML6
uniprot id: A0A2K6R556
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
messages: cytoskeleton

61622:DDRGK1
gene id: 61622:DDRGK1
uniprot id: A0A2K6PHK5
names: Similarity
messages: Belongs to the DDRGK1 family.

61622:SPCS3
gene id: 61622:SPCS3
uniprot id: A0A2K6QUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane

61622:LOC104673767
gene id: 61622:LOC104673767
uniprot id: A0A2K6NXX5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:TEX13A
gene id: 61622:TEX13A
uniprot id: A0A2K6QZW7
names: Similarity
messages: Belongs to the TEX13 family.

61622:SLC17A3
gene id: 61622:SLC17A3
uniprot id: A0A2K6QEM8
names: Subcellular Location Annotation
messages: Membrane

61622:IL10
gene id: 61622:IL10
uniprot id: A0A2K6RPG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

61622:TP53
gene id: 61622:TP53
uniprot id: A0A2K6QDI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

61622:STK3
gene id: 61622:STK3
uniprot id: A0A2K6N9K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

61622:EMP1
gene id: 61622:EMP1
uniprot id: A0A2K6NEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

61622:AVPR1B
gene id: 61622:AVPR1B
uniprot id: A0A2K6QM94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

61622:DNAAF2
gene id: 61622:DNAAF2
uniprot id: A0A2K6PBF3
uniprot id: A0A2K6PBJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

61622:GABPA
gene id: 61622:GABPA
uniprot id: A0A2K6PVZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:GOLPH3
gene id: 61622:GOLPH3
uniprot id: A0A2K6QAE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

61622:GRB10
gene id: 61622:GRB10
uniprot id: A0A2K6QUF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

61622:DPH3P1
gene id: 61622:DPH3P1
uniprot id: A0A2K6NAF7
names: Similarity
messages: Belongs to the DPH3 family.

61622:DEFB116
gene id: 61622:DEFB116
uniprot id: A0A2K6RH25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:ENTPD5
gene id: 61622:ENTPD5
uniprot id: A0A2K6R7E5
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:LHFPL6
gene id: 61622:LHFPL6
uniprot id: A0A2K6QX08
names: Subcellular Location Annotation
messages: Membrane

61622:PTPRK
gene id: 61622:PTPRK
uniprot id: A0A2K6R0S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
messages: Membrane

61622:PTH2
gene id: 61622:PTH2
uniprot id: A0A2K6QEH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: Secreted

61622:CLRN3
gene id: 61622:CLRN3
uniprot id: A0A2K6NA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

61622:RPL26L1
gene id: 61622:RPL26L1
uniprot id: A0A2K6PX37
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:PRIMPOL
gene id: 61622:PRIMPOL
uniprot id: A0A2K6RG32
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

61622:GOT1
gene id: 61622:GOT1
uniprot id: A0A2K6RTE5
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

61622:UNC5B
gene id: 61622:UNC5B
uniprot id: A0A2K6P3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

61622:XAGE2
gene id: 61622:XAGE2
uniprot id: A0A2K6PPV8
names: Similarity
messages: Belongs to the GAGE family.

61622:MS4A5
gene id: 61622:MS4A5
uniprot id: A0A2K6QI89
names: Similarity
messages: Belongs to the MS4A family.

61622:ITGAM
gene id: 61622:ITGAM
uniprot id: A0A2K6NUA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:LOC104667124
gene id: 61622:LOC104667124
uniprot id: A0A2K6N9I7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61622:C2
gene id: 61622:C2
uniprot id: A0A2K6PAW7
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:CBR3
gene id: 61622:CBR3
uniprot id: A0A2K6QE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

61622:GALK2
gene id: 61622:GALK2
uniprot id: A0A2K6Q0S9
uniprot id: A0A2K6Q0T5
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

61622:GNPDA1
gene id: 61622:GNPDA1
uniprot id: A0A2K6QMD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

61622:EIF4E1B
gene id: 61622:EIF4E1B
uniprot id: A0A2K6R8F4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

61622:DLX6
gene id: 61622:DLX6
uniprot id: A0A2K6PW56
names: Subcellular Location Annotation
messages: Nucleus

61622:IL7
gene id: 61622:IL7
uniprot id: A0A2K6NZH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Secreted

61622:CTSD
gene id: 61622:CTSD
uniprot id: A0A2K6Q181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

61622:LOC104671069
gene id: 61622:LOC104671069
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:PSMB2
gene id: 61622:PSMB2
uniprot id: A0A2K6NYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61622:GAA
gene id: 61622:GAA
uniprot id: A0A2K6NW26
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SEC24C
gene id: 61622:SEC24C
uniprot id: A0A2K6PVH2
uniprot id: A0A2K6PVH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61622:MRPL51
gene id: 61622:MRPL51
uniprot id: A0A2K6NL88
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

61622:TNP2
gene id: 61622:TNP2
uniprot id: A0A2K6NXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
messages: nucleolus

61622:MIOX
gene id: 61622:MIOX
uniprot id: A0A2K6Q3J2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

61622:NSUN4
gene id: 61622:NSUN4
uniprot id: A0A2K6N7B1
uniprot id: A0A2K6N7B2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

61622:LOC104669207
gene id: 61622:LOC104669207
uniprot id: A0A2K6QI90
names: Subcellular Location Annotation
messages: Membrane

61622:SCD
gene id: 61622:SCD
uniprot id: A0A2K6QV31
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

61622:TRIM23
gene id: 61622:TRIM23
uniprot id: A0A2K6P818
names: Subcellular Location Annotation
messages: Nucleus

61622:KLC3
gene id: 61622:KLC3
uniprot id: A0A2K6NBP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

61622:SNCG
gene id: 61622:SNCG
uniprot id: A0A2K6NMQ4
names: Similarity
names: Subunit
messages: Belongs to the synuclein family.
messages: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation.

61622:GABRA2
gene id: 61622:GABRA2
uniprot id: A0A2K6RDM1
uniprot id: A0A2K6RDP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

61622:SLC6A5
gene id: 61622:SLC6A5
uniprot id: A0A2K6R3G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:RAB3B
gene id: 61622:RAB3B
uniprot id: A0A2K6QSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

61622:APOLD1
gene id: 61622:APOLD1
uniprot id: A0A2K6QFZ8
names: Similarity
messages: Belongs to the apolipoprotein L family.

61622:PPIB
gene id: 61622:PPIB
uniprot id: A0A2K6Q3I8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:CORO7
gene id: 61622:CORO7
uniprot id: A0A2K6RH47
uniprot id: A0A2K6RH62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Cytoplasmic vesicle
messages: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicle
messages: cytosol
messages: trans-Golgi network

61622:CENPK
gene id: 61622:CENPK
uniprot id: A0A2K6QD54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

61622:FTH1
gene id: 61622:FTH1
uniprot id: A0A2K6P455
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:TENT5C
gene id: 61622:TENT5C
uniprot id: A0A2K6N902
names: Similarity
messages: Belongs to the TENT family.

61622:NPNT
gene id: 61622:NPNT
uniprot id: A0A2K6RG62
uniprot id: A0A2K6RG90
names: Caution
names: Similarity
messages: Belongs to the nephronectin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:BEX1
gene id: 61622:BEX1
uniprot id: A0A2K6QK87
names: Similarity
messages: Belongs to the BEX family.

61622:ADCY2
gene id: 61622:ADCY2
uniprot id: A0A2K6P7N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

61622:ATP2B2
gene id: 61622:ATP2B2
uniprot id: A0A2K6PRX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:NDUFB8
gene id: 61622:NDUFB8
uniprot id: A0A2K6RHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:FAM3C
gene id: 61622:FAM3C
uniprot id: A0A2K6QG61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

61622:TBCA
gene id: 61622:TBCA
uniprot id: A0A2K6QY21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

61622:C20H16orf72
gene id: 61622:C20H16orf72
uniprot id: A0A2K6QI54
names: Similarity
messages: Belongs to the TAPR1 family.

61622:C11H10orf53
gene id: 61622:C11H10orf53
uniprot id: A0A2K6Q7I8
names: Similarity
messages: Belongs to the UPF0728 family.

61622:SLC39A10
gene id: 61622:SLC39A10
uniprot id: A0A2K6QW25
names: Subcellular Location Annotation
messages: Membrane

61622:INKA2
gene id: 61622:INKA2
uniprot id: A0A2K6NPF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INKA family.
messages: Nucleus

61622:DUSP16
gene id: 61622:DUSP16
uniprot id: A0A2K6PKN1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61622:HSP90B1
gene id: 61622:HSP90B1
uniprot id: A0A2K6R466
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

61622:KCNB2
gene id: 61622:KCNB2
uniprot id: A0A2K6NUN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Perikaryon

61622:LOC104669000
gene id: 61622:LOC104669000
uniprot id: A0A2K6NL85
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

61622:AMOT
gene id: 61622:AMOT
uniprot id: A0A2K6QUK8
names: Similarity
messages: Belongs to the angiomotin family.

61622:C15H11orf54
gene id: 61622:C15H11orf54
uniprot id: A0A2K6QKJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

61622:MOV10
gene id: 61622:MOV10
uniprot id: A0A2K6R2L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

61622:TULP1
gene id: 61622:TULP1
uniprot id: A0A2K6P292
names: Similarity
messages: Belongs to the TUB family.

61622:TMPRSS2
gene id: 61622:TMPRSS2
uniprot id: A0A2K6PKH3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PAIP2B
gene id: 61622:PAIP2B
uniprot id: A0A2K6P2L6
names: Similarity
messages: Belongs to the PAIP2 family.

61622:HOXB7
gene id: 61622:HOXB7
uniprot id: A0A2K6Q0V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:ODR4
gene id: 61622:ODR4
uniprot id: A0A2K6PMH9
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

61622:FGF13
gene id: 61622:FGF13
uniprot id: A0A2K6QSR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

61622:ITGB3BP
gene id: 61622:ITGB3BP
uniprot id: A0A2K6R958
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcription coregulator that can have both coactivator and corepressor functions.
messages: centromere
messages: kinetochore

61622:UBR1
gene id: 61622:UBR1
uniprot id: A0A2K6P597
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

61622:GPR157
gene id: 61622:GPR157
uniprot id: A0A2K6RR93
names: Subcellular Location Annotation
messages: Membrane

61622:SRP72
gene id: 61622:SRP72
uniprot id: A0A2K6Q4R7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

61622:VIM
gene id: 61622:VIM
uniprot id: A0A2K6RGQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
messages: Membrane
messages: Nucleus matrix
messages: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

61622:CLCN2
gene id: 61622:CLCN2
uniprot id: A0A2K6PXD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.
messages: Cell membrane
messages: Membrane

61622:CD164L2
gene id: 61622:CD164L2
uniprot id: A0A2K6PPR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

61622:PIGN
gene id: 61622:PIGN
uniprot id: A0A2K6NND4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

61622:CLEC18C
gene id: 61622:CLEC18C
uniprot id: A0A2K6RRM2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PCMT1
gene id: 61622:PCMT1
uniprot id: A0A2K6R8P6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61622:LYRM7
gene id: 61622:LYRM7
uniprot id: A0A2K6Q6Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

61622:ANKRD34B
gene id: 61622:ANKRD34B
uniprot id: A0A2K6NK84
names: Similarity
messages: Belongs to the ANKRD34 family.

61622:ITGAV
gene id: 61622:ITGAV
uniprot id: A0A2K6NBD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:TP73
gene id: 61622:TP73
uniprot id: A0A2K6RQ20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Found in a complex with p53/TP53 and CABLES1.
messages: Nucleus
messages: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

61622:DDAH2
gene id: 61622:DDAH2
uniprot id: A0A2K6PQZ4
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

61622:MDH1
gene id: 61622:MDH1
uniprot id: A0A2K6Q8C4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

61622:EPN2
gene id: 61622:EPN2
uniprot id: A0A2K6NGX1
names: Similarity
messages: Belongs to the epsin family.

61622:STX5
gene id: 61622:STX5
uniprot id: A0A2K6P210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

61622:ASB6
gene id: 61622:ASB6
uniprot id: A0A2K6PCK3
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:FGFR4
gene id: 61622:FGFR4
uniprot id: A0A2K6RCG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Membrane

61622:SSBP2
gene id: 61622:SSBP2
uniprot id: A0A2K6QXY5
uniprot id: A0A2K6QY18
uniprot id: A0A2K6QY41
names: Subcellular Location Annotation
messages: Nucleus

61622:LARP7
gene id: 61622:LARP7
uniprot id: A0A2K6PQF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LARP7 family.
messages: nucleoplasm

61622:ZC3H15
gene id: 61622:ZC3H15
uniprot id: A0A2K6NUG3
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

61622:PON2
gene id: 61622:PON2
uniprot id: A0A2K6R302
names: Cofactor
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.

61622:LCTL
gene id: 61622:LCTL
uniprot id: A0A2K6QZG6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

61622:TFAP2C
gene id: 61622:TFAP2C
uniprot id: A0A2K6R0Y5
names: Similarity
messages: Belongs to the AP-2 family.

61622:CBX7
gene id: 61622:CBX7
uniprot id: A0A2K6PS30
names: Subcellular Location Annotation
messages: Nucleus

61622:LDLRAD2
gene id: 61622:LDLRAD2
uniprot id: A0A2K6P356
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LIPA
gene id: 61622:LIPA
uniprot id: A0A2K6R9M2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:CAVIN4
gene id: 61622:CAVIN4
uniprot id: A0A2K6PRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

61622:RBP5
gene id: 61622:RBP5
uniprot id: A0A2K6PT16
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:SPC25
gene id: 61622:SPC25
uniprot id: A0A2K6PTS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

61622:PLPP4
gene id: 61622:PLPP4
uniprot id: A0A2K6QGD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:LOC104675473
gene id: 61622:LOC104675473
uniprot id: A0A2K6P2X9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M2 family.
messages: Binds 2 Zn(2+) ions per subunit.

61622:FOXS1
gene id: 61622:FOXS1
uniprot id: A0A2K6NAK7
names: Subcellular Location Annotation
messages: Nucleus

61622:TSG101
gene id: 61622:TSG101
uniprot id: A0A2K6NCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.
messages: Endosome membrane
messages: Membrane

61622:RAB4A
gene id: 61622:RAB4A
uniprot id: A0A2K6RHT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

61622:HOXB5
gene id: 61622:HOXB5
uniprot id: A0A2K6P899
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:MALSU1
gene id: 61622:MALSU1
uniprot id: A0A2K6RPZ1
names: Similarity
messages: Belongs to the Iojap/RsfS family.

61622:GK
gene id: 61622:GK
uniprot id: A0A2K6P362
uniprot id: A0A2K6P364
uniprot id: A0A2K6P386
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

61622:ZUP1
gene id: 61622:ZUP1
uniprot id: A0A2K6N863
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

61622:GLYR1
gene id: 61622:GLYR1
uniprot id: A0A2K6NX87
uniprot id: A0A2K6NX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

61622:ALDH8A1
gene id: 61622:ALDH8A1
uniprot id: A0A2K6QUN0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:PGK2
gene id: 61622:PGK2
uniprot id: A0A2K6NF91
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

61622:TRMT44
gene id: 61622:TRMT44
uniprot id: A0A2K6PD22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm

61622:IPO13
gene id: 61622:IPO13
uniprot id: A0A2K6QSU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the importin beta family.
messages: Cytoplasm
messages: Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
messages: Nucleus

61622:PDP1
gene id: 61622:PDP1
uniprot id: A0A2K6PT58
names: Similarity
messages: Belongs to the PP2C family.

61622:NUP93
gene id: 61622:NUP93
uniprot id: A0A2K6RU43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus envelope
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

61622:PTDSS2
gene id: 61622:PTDSS2
uniprot id: A0A2K6Q6E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:AQP11
gene id: 61622:AQP11
uniprot id: A0A2K6RLD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Membrane

61622:ATP5F1B
gene id: 61622:ATP5F1B
uniprot id: A0A2K6Q8K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

61622:MINDY2
gene id: 61622:MINDY2
uniprot id: A0A2K6NZS6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

61622:MARK2
gene id: 61622:MARK2
uniprot id: A0A2K6P790
uniprot id: A0A2K6P7D5
uniprot id: A0A2K6P7E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

61622:FOXP3
gene id: 61622:FOXP3
uniprot id: A0A2K6QM36
uniprot id: A0A2K6QM63
names: Subcellular Location Annotation
messages: Nucleus

61622:GMFG
gene id: 61622:GMFG
uniprot id: A0A2K6RWN9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

61622:LOC104682317
gene id: 61622:LOC104682317
uniprot id: A0A2K6NCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

61622:AGTR2
gene id: 61622:AGTR2
uniprot id: A0A2K6NI00
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MTUS1.
messages: Membrane

61622:CAMTA2
gene id: 61622:CAMTA2
uniprot id: A0A2K6QI41
uniprot id: A0A2K6QI48
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

61622:C4H6orf89
gene id: 61622:C4H6orf89
uniprot id: A0A2K6R7D8
uniprot id: A0A2K6R7E3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

61622:APLN
gene id: 61622:APLN
uniprot id: A0A2K6RR72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apelin family.
messages: extracellular space

61622:POLR1A
gene id: 61622:POLR1A
uniprot id: A0A2K6PDI7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61622:UBE2D2
gene id: 61622:UBE2D2
uniprot id: A0A2K6QJE9
uniprot id: A0A2K6QJF9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:MBOAT1
gene id: 61622:MBOAT1
uniprot id: A0A2K6PMC5
names: Subcellular Location Annotation
messages: Membrane

61622:PNO1
gene id: 61622:PNO1
uniprot id: A0A2K6NDB8
names: Similarity
messages: Belongs to the PNO1 family.

61622:CRYBA2
gene id: 61622:CRYBA2
uniprot id: A0A2K6RBP2
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:LOC104680738
gene id: 61622:LOC104680738
uniprot id: A0A2K6QH48
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:TXLNG
gene id: 61622:TXLNG
uniprot id: A0A2K6QZ03
names: Similarity
messages: Belongs to the taxilin family.

61622:LOC104679032
gene id: 61622:LOC104679032
uniprot id: A0A2K6QUT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-defensin family.
messages: Secreted

61622:GPC4
gene id: 61622:GPC4
uniprot id: A0A2K6QA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan that bears heparan sulfate.

61622:COMTD1
gene id: 61622:COMTD1
uniprot id: A0A2K6REV3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

61622:CDC73
gene id: 61622:CDC73
uniprot id: A0A2K6NER2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

61622:GLS
gene id: 61622:GLS
uniprot id: A0A2K6R820
uniprot id: A0A2K6R830
names: Similarity
messages: Belongs to the glutaminase family.

61622:ELOVL3
gene id: 61622:ELOVL3
uniprot id: A0A2K6QWS3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL3 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61622:GNAT2
gene id: 61622:GNAT2
uniprot id: A0A2K6R4N5
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61622:RPL18A
gene id: 61622:RPL18A
uniprot id: A0A2K6NEM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

61622:OPN1SW
gene id: 61622:OPN1SW
uniprot id: A0A2K6Q2T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

61622:SULT4A1
gene id: 61622:SULT4A1
uniprot id: A0A2K6RQH6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:SERINC5
gene id: 61622:SERINC5
uniprot id: A0A2K6QCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Cell membrane
messages: Membrane

61622:ATP5MC1
gene id: 61622:ATP5MC1
uniprot id: A0A2K6PB88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

61622:KCNMB4
gene id: 61622:KCNMB4
uniprot id: A0A2K6Q2X1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

61622:DCK
gene id: 61622:DCK
uniprot id: A0A2K6QUM1
names: Similarity
messages: Belongs to the DCK/DGK family.

61622:ATL3
gene id: 61622:ATL3
uniprot id: A0A2K6QBA5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:GLP1R
gene id: 61622:GLP1R
uniprot id: A0A2K6Q8N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

61622:NEUROD6
gene id: 61622:NEUROD6
uniprot id: A0A2K6NUS2
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

61622:FBP2
gene id: 61622:FBP2
uniprot id: A0A2K6QW76
names: Similarity
messages: Belongs to the FBPase class 1 family.

61622:NDUFS1
gene id: 61622:NDUFS1
uniprot id: A0A2K6PTZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

61622:SAMHD1
gene id: 61622:SAMHD1
uniprot id: A0A2K6PXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAMHD1 family.
messages: Chromosome

61622:MBLAC1
gene id: 61622:MBLAC1
uniprot id: A0A2K6NMR2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

61622:IQCG
gene id: 61622:IQCG
uniprot id: A0A2K6N888
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC9 family.
messages: flagellum
messages: flagellum axoneme

61622:SMARCAL1
gene id: 61622:SMARCAL1
uniprot id: A0A2K6Q8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

61622:LOC104668988
gene id: 61622:LOC104668988
uniprot id: A0A2K6PM53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

61622:ZADH2
gene id: 61622:ZADH2
uniprot id: A0A2K6PJW8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61622:SFMBT1
gene id: 61622:SFMBT1
uniprot id: A0A2K6QUT9
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104656160
gene id: 61622:LOC104656160
uniprot id: A0A2K6RW11
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

61622:LSM8
gene id: 61622:LSM8
uniprot id: A0A2K6QT12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

61622:RECQL
gene id: 61622:RECQL
uniprot id: A0A2K6NE73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

61622:ELK4
gene id: 61622:ELK4
uniprot id: A0A2K6QKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:NLGN4X
gene id: 61622:NLGN4X
uniprot id: A0A2K6P1U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

61622:SLC25A32
gene id: 61622:SLC25A32
uniprot id: A0A2K6RBH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:DOHH
gene id: 61622:DOHH
uniprot id: A0A2K6RKC0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

61622:RAB3IP
gene id: 61622:RAB3IP
uniprot id: A0A2K6P731
uniprot id: A0A2K6P740
uniprot id: A0A2K6P746
names: Similarity
messages: Belongs to the SEC2 family.

61622:LOC104655295
gene id: 61622:LOC104655295
uniprot id: A0A2K6RLH6
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:ARHGEF28
gene id: 61622:ARHGEF28
uniprot id: A0A2K6NY99
names: Subcellular Location Annotation
messages: Cytoplasm

61622:USP4
gene id: 61622:USP4
uniprot id: A0A2K6QFY2
uniprot id: A0A2K6QG08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

61622:HMGB1
gene id: 61622:HMGB1
uniprot id: A0A2K6PP51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Cell membrane
messages: Chromosome
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Secreted

61622:RPL5
gene id: 61622:RPL5
uniprot id: A0A2K6N932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

61622:LOC104657557
gene id: 61622:LOC104657557
uniprot id: A0A2K6Q2L3
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

61622:ARMC9
gene id: 61622:ARMC9
uniprot id: A0A2K6PUL4
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
messages: centriole
messages: cilium
messages: cilium basal body

61622:TAS1R3
gene id: 61622:TAS1R3
uniprot id: A0A2K6NDK5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104668069
gene id: 61622:LOC104668069
uniprot id: A0A2K6NRK7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

61622:SGCE
gene id: 61622:SGCE
uniprot id: A0A2K6NB59
uniprot id: A0A2K6NB71
uniprot id: A0A2K6NB84
uniprot id: A0A2K6NB92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan alpha/epsilon family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Golgi apparatus
messages: cytoskeleton
messages: dendrite
messages: sarcolemma

61622:F13A1
gene id: 61622:F13A1
uniprot id: A0A2K6NX06
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:NFKB1
gene id: 61622:NFKB1
uniprot id: A0A2K6RUX3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:G6PC
gene id: 61622:G6PC
uniprot id: A0A2K6NKG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

61622:TRMU
gene id: 61622:TRMU
uniprot id: A0A2K6NA23
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

61622:CCND3
gene id: 61622:CCND3
uniprot id: A0A2K6R2X6
uniprot id: A0A2K6R312
uniprot id: A0A2K6R314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

61622:TMEM50B
gene id: 61622:TMEM50B
uniprot id: A0A2K6Q756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

61622:SVEP1
gene id: 61622:SVEP1
uniprot id: A0A2K6RCA2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:MRPL30
gene id: 61622:MRPL30
uniprot id: A0A2K6RQC7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

61622:SRPRA
gene id: 61622:SRPRA
uniprot id: A0A2K6P0W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

61622:NAGK
gene id: 61622:NAGK
uniprot id: A0A2K6RWD1
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

61622:PIK3CG
gene id: 61622:PIK3CG
uniprot id: A0A2K6PG88
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:RUNX1
gene id: 61622:RUNX1
uniprot id: A0A2K6R9F3
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

61622:TGM5
gene id: 61622:TGM5
uniprot id: A0A2K6NRB0
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:CDC20
gene id: 61622:CDC20
uniprot id: A0A2K6P3I4
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

61622:LOC104661614
gene id: 61622:LOC104661614
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:MVP
gene id: 61622:MVP
uniprot id: A0A2K6PIA2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

61622:ARGLU1
gene id: 61622:ARGLU1
uniprot id: A0A2K6NCU6
names: Similarity
messages: Belongs to the UPF0430 family.

61622:SLC10A1
gene id: 61622:SLC10A1
uniprot id: A0A2K6R9W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61622:DBX1
gene id: 61622:DBX1
uniprot id: A0A2K6NBY8
names: Subcellular Location Annotation
messages: Nucleus

61622:JMY
gene id: 61622:JMY
uniprot id: A0A2K6PD34
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104674019
gene id: 61622:LOC104674019
uniprot id: A0A2K6NFQ1
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61622:EIF3F
gene id: 61622:EIF3F
uniprot id: A0A2K6PTA5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

61622:CLK1
gene id: 61622:CLK1
uniprot id: A0A2K6Q239
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:AP1G2
gene id: 61622:AP1G2
uniprot id: A0A2K6Q082
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:EIF3H
gene id: 61622:EIF3H
uniprot id: A0A2K6PN16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

61622:MAN2B2
gene id: 61622:MAN2B2
uniprot id: A0A2K6R7L4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

61622:LCN6
gene id: 61622:LCN6
uniprot id: A0A2K6PHT4
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:ADAMTS18
gene id: 61622:ADAMTS18
uniprot id: A0A2K6P3T5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:SOD2
gene id: 61622:SOD2
uniprot id: A0A2K6NUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

61622:EFNB3
gene id: 61622:EFNB3
uniprot id: A0A2K6RVU5
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MFAP3
gene id: 61622:MFAP3
uniprot id: A0A2K6PQ48
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104664026
gene id: 61622:LOC104664026
uniprot id: A0A2K6NQP4
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:CAMK1G
gene id: 61622:CAMK1G
uniprot id: A0A2K6R3C7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LETMD1
gene id: 61622:LETMD1
uniprot id: A0A2K6RC74
uniprot id: A0A2K6RC79
names: Subcellular Location Annotation
messages: Membrane

61622:ALG14
gene id: 61622:ALG14
uniprot id: A0A2K6NYD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG14 family.
messages: Membrane
messages: Nucleus membrane

61622:PAICS
gene id: 61622:PAICS
uniprot id: A0A2K6QWN2
uniprot id: A0A2K6QWQ5
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

61622:IFI27L2
gene id: 61622:IFI27L2
uniprot id: A0A2K6PR32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

61622:DYNC1LI2
gene id: 61622:DYNC1LI2
uniprot id: A0A2K6QFU4
uniprot id: A0A2K6QFX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

61622:B4GAT1
gene id: 61622:B4GAT1
uniprot id: A0A2K6PD90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:LOC104681686
gene id: 61622:LOC104681686
uniprot id: A0A2K6QKB4
uniprot id: A0A2K6QKC1
names: Caution
names: Function
names: Subunit
messages: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.
messages: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MIGA1
gene id: 61622:MIGA1
uniprot id: A0A2K6Q5Y3
names: Similarity
messages: Belongs to the mitoguardin family.

61622:UGP2
gene id: 61622:UGP2
uniprot id: A0A2K6RHR5
uniprot id: A0A2K6RHS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

61622:RPL8
gene id: 61622:RPL8
uniprot id: A0A2K6NSR2
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

61622:NAGA
gene id: 61622:NAGA
uniprot id: A0A2K6NBU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

61622:CCK
gene id: 61622:CCK
uniprot id: A0A2K6QUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

61622:UBE2H
gene id: 61622:UBE2H
uniprot id: A0A2K6QNK2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:PARK7
gene id: 61622:PARK7
uniprot id: A0A2K6RMF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

61622:GABARAPL1
gene id: 61622:GABARAPL1
uniprot id: A0A2K6Q8Z0
names: Similarity
messages: Belongs to the ATG8 family.

61622:VEPH1
gene id: 61622:VEPH1
uniprot id: A0A2K6QQ89
names: Similarity
messages: Belongs to the MELT/VEPH family.

61622:CPT2
gene id: 61622:CPT2
uniprot id: A0A2K6P282
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61622:LETM1
gene id: 61622:LETM1
uniprot id: A0A2K6QN82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LETM1 family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:CWF19L1
gene id: 61622:CWF19L1
uniprot id: A0A2K6RIQ5
names: Similarity
messages: Belongs to the CWF19 family.

61622:ACSL6
gene id: 61622:ACSL6
uniprot id: A0A2K6NNM2
uniprot id: A0A2K6NNM6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane

61622:SGMS1
gene id: 61622:SGMS1
uniprot id: A0A2K6RX68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

61622:NAPG
gene id: 61622:NAPG
uniprot id: A0A2K6RNN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

61622:TOPAZ1
gene id: 61622:TOPAZ1
uniprot id: A0A2K6PG36
names: Function
names: Subcellular Location Annotation
messages: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
messages: cytosol

61622:LOC104656530
gene id: 61622:LOC104656530
uniprot id: A0A2K6QUI5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:FTO
gene id: 61622:FTO
uniprot id: A0A2K6QQ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fto family.
messages: Cytoplasm
messages: Nucleus speckle

61622:FAM124B
gene id: 61622:FAM124B
uniprot id: A0A2K6PM62
names: Similarity
messages: Belongs to the FAM124 family.

61622:ZPBP
gene id: 61622:ZPBP
uniprot id: A0A2K6QGW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zona pellucida-binding protein Sp38 family.
messages: Secreted

61622:LEPROTL1
gene id: 61622:LEPROTL1
uniprot id: A0A2K6NZV3
uniprot id: A0A2K6NZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

61622:GBF1
gene id: 61622:GBF1
uniprot id: A0A2K6PNT0
names: Subcellular Location Annotation
messages: Golgi apparatus

61622:MCHR1
gene id: 61622:MCHR1
uniprot id: A0A2K6PB95
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with NCDN.
messages: Membrane

61622:ATP5MF
gene id: 61622:ATP5MF
uniprot id: A0A2K6Q417
uniprot id: A0A2K6Q420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

61622:SLC12A6
gene id: 61622:SLC12A6
uniprot id: A0A2K6PIX9
uniprot id: A0A2K6PIZ1
uniprot id: A0A2K6PJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:SPDYA
gene id: 61622:SPDYA
uniprot id: A0A2K6NP82
names: Similarity
messages: Belongs to the Speedy/Ringo family.

61622:RPS19
gene id: 61622:RPS19
uniprot id: A0A2K6NM61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

61622:ALKBH2
gene id: 61622:ALKBH2
uniprot id: A0A2K6PVN6
names: Similarity
messages: Belongs to the alkB family.

61622:PC
gene id: 61622:PC
uniprot id: A0A2K6NY42
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

61622:PPP4R2
gene id: 61622:PPP4R2
uniprot id: A0A2K6NGL4
names: Similarity
messages: Belongs to the PPP4R2 family.

61622:PTGES
gene id: 61622:PTGES
uniprot id: A0A2K6NSK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

61622:VANGL1
gene id: 61622:VANGL1
uniprot id: A0A2K6RWG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

61622:HOXC8
gene id: 61622:HOXC8
uniprot id: A0A2K6QCN7
names: Subcellular Location Annotation
messages: Nucleus

61622:TMPRSS5
gene id: 61622:TMPRSS5
uniprot id: A0A2K6QU58
uniprot id: A0A2K6QU75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:DIP2B
gene id: 61622:DIP2B
uniprot id: A0A2K6QPU3
names: Similarity
messages: Belongs to the DIP2 family.

61622:ESCO1
gene id: 61622:ESCO1
uniprot id: A0A2K6R0S7
names: Subcellular Location Annotation
messages: Nucleus

61622:BUD13
gene id: 61622:BUD13
uniprot id: A0A2K6PX73
names: Similarity
messages: Belongs to the CWC26 family.

61622:WNK1
gene id: 61622:WNK1
uniprot id: A0A2K6QPI9
uniprot id: A0A2K6QPK1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

61622:FAM214B
gene id: 61622:FAM214B
uniprot id: A0A2K6RNZ5
names: Similarity
messages: Belongs to the FAM214 family.

61622:ETV7
gene id: 61622:ETV7
uniprot id: A0A2K6PMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:LOC104672978
gene id: 61622:LOC104672978
uniprot id: A0A2K6P563
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:ELOVL5
gene id: 61622:ELOVL5
uniprot id: A0A2K6QNQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

61622:NR1I2
gene id: 61622:NR1I2
uniprot id: A0A2K6NS50
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104671488
gene id: 61622:LOC104671488
uniprot id: A0A2K6Q045
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:ACER3
gene id: 61622:ACER3
uniprot id: A0A2K6PZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

61622:SLC39A9
gene id: 61622:SLC39A9
uniprot id: A0A2K6R8I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: May act as a zinc-influx transporter.
messages: Membrane

61622:SPPL2B
gene id: 61622:SPPL2B
uniprot id: A0A2K6R1L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

61622:SLC34A2
gene id: 61622:SLC34A2
uniprot id: A0A2K6PBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

61622:DONSON
gene id: 61622:DONSON
uniprot id: A0A2K6R6U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DONSON family.
messages: Nucleus

61622:HGFAC
gene id: 61622:HGFAC
uniprot id: A0A2K6QPI1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:VBP1
gene id: 61622:VBP1
uniprot id: A0A2K6RJD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

61622:PDCL
gene id: 61622:PDCL
uniprot id: A0A2K6QSG9
names: Similarity
messages: Belongs to the phosducin family.

61622:MEIS3
gene id: 61622:MEIS3
uniprot id: A0A2K6NY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

61622:NCAN
gene id: 61622:NCAN
uniprot id: A0A2K6QHA3
names: Caution
names: Similarity
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NXF1
gene id: 61622:NXF1
uniprot id: A0A2K6RLR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: Cytoplasm
messages: nucleoplasm

61622:COPS7A
gene id: 61622:COPS7A
uniprot id: A0A2K6R697
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

61622:SLC43A3
gene id: 61622:SLC43A3
uniprot id: A0A2K6QL15
names: Subcellular Location Annotation
messages: Membrane

61622:CCN4
gene id: 61622:CCN4
uniprot id: A0A2K6RLM1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:PKIB
gene id: 61622:PKIB
uniprot id: A0A2K6QHE7
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

61622:C10H12orf10
gene id: 61622:C10H12orf10
uniprot id: A0A2K6P719
names: Similarity
messages: Belongs to the MYG1 family.

61622:RMND1
gene id: 61622:RMND1
uniprot id: A0A2K6Q7E0
names: Similarity
messages: Belongs to the RMD1/sif2 family.

61622:SETDB1
gene id: 61622:SETDB1
uniprot id: A0A2K6PKG3
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61622:PRR5
gene id: 61622:PRR5
uniprot id: A0A2K6NG05
names: Similarity
messages: Belongs to the PROTOR family.

61622:NAA35
gene id: 61622:NAA35
uniprot id: A0A2K6P7I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

61622:SDC4
gene id: 61622:SDC4
uniprot id: A0A2K6RN20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

61622:XRCC3
gene id: 61622:XRCC3
uniprot id: A0A2K6Q0K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

61622:LOC104674022
gene id: 61622:LOC104674022
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:AFMID
gene id: 61622:AFMID
uniprot id: A0A2K6PFT9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

61622:SNX3
gene id: 61622:SNX3
uniprot id: A0A2K6QHJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

61622:ATP13A4
gene id: 61622:ATP13A4
uniprot id: A0A2K6PC01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

61622:SLC51A
gene id: 61622:SLC51A
uniprot id: A0A2K6PG19
names: Subcellular Location Annotation
messages: Membrane

61622:RAB3GAP2
gene id: 61622:RAB3GAP2
uniprot id: A0A2K6PHJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

61622:UNC45A
gene id: 61622:UNC45A
uniprot id: A0A2K6NZA1
names: Subcellular Location Annotation
messages: perinuclear region

61622:IFT46
gene id: 61622:IFT46
uniprot id: A0A2K6QAD8
uniprot id: A0A2K6QAH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT46 family.
messages: cilium
messages: cilium basal body

61622:VPS51
gene id: 61622:VPS51
uniprot id: A0A2K6PQF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

61622:MOXD1
gene id: 61622:MOXD1
uniprot id: A0A2K6RJ15
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

61622:PHF5A
gene id: 61622:PHF5A
uniprot id: A0A2K6QNN6
names: Similarity
messages: Belongs to the PHF5 family.

61622:DGAT2
gene id: 61622:DGAT2
uniprot id: A0A2K6NZQ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:POU3F4
gene id: 61622:POU3F4
uniprot id: A0A2K6NLP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

61622:TMC7
gene id: 61622:TMC7
uniprot id: A0A2K6RAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:LCN15
gene id: 61622:LCN15
uniprot id: A0A2K6PWL2
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:ISL1
gene id: 61622:ISL1
uniprot id: A0A2K6P0S2
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104672415
gene id: 61622:LOC104672415
uniprot id: A0A2K6NW60
names: Similarity
messages: Belongs to the CFAP36 family.

61622:MYB
gene id: 61622:MYB
uniprot id: A0A2K6QNL9
uniprot id: A0A2K6QNN4
names: Subcellular Location Annotation
messages: Nucleus

61622:BRS3
gene id: 61622:BRS3
uniprot id: A0A2K6NXV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with C6orf89.
messages: Membrane

61622:AGAP2
gene id: 61622:AGAP2
uniprot id: A0A2K6NM77
names: Similarity
messages: Belongs to the centaurin gamma-like family.

61622:PRKRIP1
gene id: 61622:PRKRIP1
uniprot id: A0A2K6RI60
names: Similarity
messages: Belongs to the PRKRIP1 family.

61622:HMGA2
gene id: 61622:HMGA2
uniprot id: A0A2K6PJ63
uniprot id: A0A2K6PJ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

61622:SLC23A2
gene id: 61622:SLC23A2
uniprot id: A0A2K6PSY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

61622:BBS7
gene id: 61622:BBS7
uniprot id: A0A2K6NGH9
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

61622:TMEM251
gene id: 61622:TMEM251
uniprot id: A0A2K6Q2Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

61622:SLC27A5
gene id: 61622:SLC27A5
uniprot id: A0A2K6RJ55
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:S100A16
gene id: 61622:S100A16
uniprot id: A0A2K6Q947
names: Similarity
messages: Belongs to the S-100 family.

61622:CRYBG3
gene id: 61622:CRYBG3
uniprot id: A0A2K6RTA9
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:C15H11orf58
gene id: 61622:C15H11orf58
uniprot id: A0A2K6QR01
names: Similarity
messages: Belongs to the SMAP family.

61622:ZZZ3
gene id: 61622:ZZZ3
uniprot id: A0A2K6QHS2
names: Subcellular Location Annotation
messages: Nucleus

61622:EIF2A
gene id: 61622:EIF2A
uniprot id: A0A2K6QR05
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

61622:POU1F1
gene id: 61622:POU1F1
uniprot id: A0A2K6Q9Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-1 subfamily.
messages: Nucleus

61622:SLC37A1
gene id: 61622:SLC37A1
uniprot id: A0A2K6Q8L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

61622:GNRHR
gene id: 61622:GNRHR
uniprot id: A0A2K6NG54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SERPINA6
gene id: 61622:SERPINA6
uniprot id: A0A2K6R2F6
names: Similarity
messages: Belongs to the serpin family.

61622:PDE5A
gene id: 61622:PDE5A
uniprot id: A0A2K6QLA3
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:WDFY1
gene id: 61622:WDFY1
uniprot id: A0A2K6QG50
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61622:PARD6A
gene id: 61622:PARD6A
uniprot id: A0A2K6NJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

61622:XRCC1
gene id: 61622:XRCC1
uniprot id: A0A2K6QDM9
uniprot id: A0A2K6QDP4
names: Subcellular Location Annotation
messages: Nucleus

61622:HEXA
gene id: 61622:HEXA
uniprot id: A0A2K6RNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

61622:SET
gene id: 61622:SET
uniprot id: A0A2K6REC5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61622:H1-5
gene id: 61622:H1-5
uniprot id: A0A2K6NJP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61622:OTOP1
gene id: 61622:OTOP1
uniprot id: A0A2K6NPV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61622:ATP6V0A1
gene id: 61622:ATP6V0A1
uniprot id: A0A2K6PZ32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

61622:LOC104678238
gene id: 61622:LOC104678238
uniprot id: A0A2K6QRW7
uniprot id: A0A2K6QRX0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:HENMT1
gene id: 61622:HENMT1
uniprot id: A0A2K6Q6P0
names: Similarity
messages: Belongs to the methyltransferase superfamily. HEN1 family.

61622:IFITM10
gene id: 61622:IFITM10
uniprot id: A0A2K6Q149
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:PSD
gene id: 61622:PSD
uniprot id: A0A2K6R3V0
names: Subcellular Location Annotation
messages: ruffle membrane

61622:BAZ2A
gene id: 61622:BAZ2A
uniprot id: A0A2K6R5R8
uniprot id: A0A2K6R5T0
names: Similarity
messages: Belongs to the WAL family.

61622:CPXM1
gene id: 61622:CPXM1
uniprot id: A0A2K6PEI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

61622:LAP3
gene id: 61622:LAP3
uniprot id: A0A2K6NPB6
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

61622:FGF9
gene id: 61622:FGF9
uniprot id: A0A2K6PV23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heparin-binding growth factors family.
messages: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
messages: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
messages: Secreted

61622:ASB15
gene id: 61622:ASB15
uniprot id: A0A2K6P1Z5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:SETD6
gene id: 61622:SETD6
uniprot id: A0A2K6RC40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

61622:NKAP
gene id: 61622:NKAP
uniprot id: A0A2K6RJG9
names: Similarity
messages: Belongs to the NKAP family.

61622:EXT2
gene id: 61622:EXT2
uniprot id: A0A2K6RMJ4
uniprot id: A0A2K6RMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LOC104670020
gene id: 61622:LOC104670020
uniprot id: A0A2K6RT88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61622:LOC104681937
gene id: 61622:LOC104681937
uniprot id: A0A2K6PEE5
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:LOC104664030
gene id: 61622:LOC104664030
uniprot id: A0A2K6R0X1
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:PINLYP
gene id: 61622:PINLYP
uniprot id: A0A2K6PMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

61622:CDH10
gene id: 61622:CDH10
uniprot id: A0A2K6P747
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:MRPL16
gene id: 61622:MRPL16
uniprot id: A0A2K6QX42
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

61622:LOC104664129
gene id: 61622:LOC104664129
uniprot id: A0A2K6QT33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:PLAU
gene id: 61622:PLAU
uniprot id: A0A2K6P8X0
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

61622:MRGPRF
gene id: 61622:MRGPRF
uniprot id: A0A2K6QBP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

61622:PIAS1
gene id: 61622:PIAS1
uniprot id: A0A2K6NYY5
names: Similarity
messages: Belongs to the PIAS family.

61622:GNGT2
gene id: 61622:GNGT2
uniprot id: A0A2K6NM33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61622:SNAP25
gene id: 61622:SNAP25
uniprot id: A0A2K6R755
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: perinuclear region
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

61622:NPRL2
gene id: 61622:NPRL2
uniprot id: A0A2K6QWB5
names: Similarity
messages: Belongs to the NPR2 family.

61622:PDHA1
gene id: 61622:PDHA1
uniprot id: A0A2K6NLY8
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

61622:SYN2
gene id: 61622:SYN2
uniprot id: A0A2K6R070
names: Similarity
messages: Belongs to the synapsin family.

61622:ERCC3
gene id: 61622:ERCC3
uniprot id: A0A2K6QZM8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

61622:RAB3D
gene id: 61622:RAB3D
uniprot id: A0A2K6PM26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

61622:RAB3IL1
gene id: 61622:RAB3IL1
uniprot id: A0A2K6NGD4
uniprot id: A0A2K6NGG4
names: Similarity
messages: Belongs to the SEC2 family.

61622:HPSE
gene id: 61622:HPSE
uniprot id: A0A2K6PZU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 79 family.

61622:TLX2
gene id: 61622:TLX2
uniprot id: A0A2K6RUE3
names: Subcellular Location Annotation
messages: Nucleus

61622:AGPAT4
gene id: 61622:AGPAT4
uniprot id: A0A2K6QMX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NUDT19
gene id: 61622:NUDT19
uniprot id: A0A2K6NI70
names: Similarity
messages: Belongs to the Nudix hydrolase family.

61622:PMS1
gene id: 61622:PMS1
uniprot id: A0A2K6PXL1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

61622:STAT3
gene id: 61622:STAT3
uniprot id: A0A2K6PPE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

61622:OPA1
gene id: 61622:OPA1
uniprot id: A0A2K6PIR7
uniprot id: A0A2K6PIT4
uniprot id: A0A2K6PIZ2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61622:GML
gene id: 61622:GML
uniprot id: A0A2K6RDD1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:UCHL5
gene id: 61622:UCHL5
uniprot id: A0A2K6NWM1
uniprot id: A0A2K6NWM7
names: Similarity
messages: Belongs to the peptidase C12 family.

61622:NDUFC2
gene id: 61622:NDUFC2
uniprot id: A0A2K6NUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

61622:KCNJ13
gene id: 61622:KCNJ13
uniprot id: A0A2K6R6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:EHD4
gene id: 61622:EHD4
uniprot id: A0A2K6PY39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

61622:REEP2
gene id: 61622:REEP2
uniprot id: A0A2K6PFW9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FAN1
gene id: 61622:FAN1
uniprot id: A0A2K6PUC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

61622:NDUFA11
gene id: 61622:NDUFA11
uniprot id: A0A2K6N7Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:EPAS1
gene id: 61622:EPAS1
uniprot id: A0A2K6R1G7
names: Subcellular Location Annotation
messages: Nucleus speckle

61622:TSPAN14
gene id: 61622:TSPAN14
uniprot id: A0A2K6R645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:FOLR1
gene id: 61622:FOLR1
uniprot id: A0A2K6R864
names: Similarity
messages: Belongs to the folate receptor family.

61622:MFSD1
gene id: 61622:MFSD1
uniprot id: A0A2K6PFB5
names: Subcellular Location Annotation
messages: Membrane

61622:CDKL3
gene id: 61622:CDKL3
uniprot id: A0A2K6Q8S5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MMP20
gene id: 61622:MMP20
uniprot id: A0A2K6QL72
names: Similarity
messages: Belongs to the peptidase M10A family.

61622:NKX2-6
gene id: 61622:NKX2-6
uniprot id: A0A2K6R6J5
names: Subcellular Location Annotation
messages: Nucleus

61622:GPAT2
gene id: 61622:GPAT2
uniprot id: A0A2K6Q6H0
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

61622:SLC25A35
gene id: 61622:SLC25A35
uniprot id: A0A2K6RH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:DTNA
gene id: 61622:DTNA
uniprot id: A0A2K6RHF0
uniprot id: A0A2K6RHG8
uniprot id: A0A2K6RHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

61622:PTGES2
gene id: 61622:PTGES2
uniprot id: A0A2K6R3A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GST superfamily.
messages: Membrane

61622:PSMD11
gene id: 61622:PSMD11
uniprot id: A0A2K6PH42
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

61622:GSX2
gene id: 61622:GSX2
uniprot id: A0A2K6P2W4
names: Subcellular Location Annotation
messages: Nucleus

61622:ARRDC3
gene id: 61622:ARRDC3
uniprot id: A0A2K6NED3
names: Similarity
messages: Belongs to the arrestin family.

61622:ING1
gene id: 61622:ING1
uniprot id: A0A2K6Q318
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:DBNDD1
gene id: 61622:DBNDD1
uniprot id: A0A2K6NTU6
names: Similarity
messages: Belongs to the dysbindin family.

61622:NCR3
gene id: 61622:NCR3
uniprot id: A0A2K6PUH0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natural cytotoxicity receptor (NCR) family.
messages: Cell membrane
messages: Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to NCR3LG1. Interacts with and is activated by binding to BAG6.
messages: Membrane

61622:NDUFS8
gene id: 61622:NDUFS8
uniprot id: A0A2K6Q4B8
names: Similarity
messages: Belongs to the complex I 23 kDa subunit family.

61622:SART3
gene id: 61622:SART3
uniprot id: A0A2K6N9S2
names: Subcellular Location Annotation
messages: nucleoplasm

61622:TMEM80
gene id: 61622:TMEM80
uniprot id: A0A2K6QU90
names: Subcellular Location Annotation
messages: Membrane

61622:LAD1
gene id: 61622:LAD1
uniprot id: A0A2K6NS34
names: Function
names: Subcellular Location Annotation
messages: Anchoring filament protein which is a component of the basement membrane zone.
messages: basement membrane

61622:NMNAT3
gene id: 61622:NMNAT3
uniprot id: A0A2K6NG59
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

61622:ETV2
gene id: 61622:ETV2
uniprot id: A0A2K6NAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:TCL1A
gene id: 61622:TCL1A
uniprot id: A0A2K6N958
names: Similarity
messages: Belongs to the TCL1 family.

61622:SLC7A9
gene id: 61622:SLC7A9
uniprot id: A0A2K6Q8T7
names: Subcellular Location Annotation
messages: Membrane

61622:LHX1
gene id: 61622:LHX1
uniprot id: A0A2K6NW71
names: Subcellular Location Annotation
messages: Nucleus

61622:NASP
gene id: 61622:NASP
uniprot id: A0A2K6NRJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

61622:TAFA3
gene id: 61622:TAFA3
uniprot id: A0A2K6RMG0
names: Similarity
messages: Belongs to the TAFA family.

61622:ELOVL4
gene id: 61622:ELOVL4
uniprot id: A0A2K6NWM0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61622:TMEM18
gene id: 61622:TMEM18
uniprot id: A0A2K6NCQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM18 family.
messages: Membrane
messages: Nucleus membrane

61622:MS4A10
gene id: 61622:MS4A10
uniprot id: A0A2K6QVV3
names: Similarity
messages: Belongs to the MS4A family.

61622:LOC115891978
gene id: 61622:LOC115891978
uniprot id: A0A2K6RVQ3
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:LOC104681238
gene id: 61622:LOC104681238
uniprot id: A0A2K6NN02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:UBE2D1
gene id: 61622:UBE2D1
uniprot id: A0A2K6QRW1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:EXOC3
gene id: 61622:EXOC3
uniprot id: A0A2K6PZA2
names: Similarity
messages: Belongs to the SEC6 family.

61622:PLCD4
gene id: 61622:PLCD4
uniprot id: A0A2K6R1F0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
messages: Nucleus

61622:ARSA
gene id: 61622:ARSA
uniprot id: A0A2K6NNX5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:C3H5orf24
gene id: 61622:C3H5orf24
uniprot id: A0A2K6P898
names: Similarity
messages: Belongs to the UPF0461 family.

61622:IGFBP4
gene id: 61622:IGFBP4
uniprot id: A0A2K6PRT9
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:VDAC2
gene id: 61622:VDAC2
uniprot id: A0A2K6Q849
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Mitochondrion outer membrane

61622:PHACTR1
gene id: 61622:PHACTR1
uniprot id: A0A2K6PPG1
uniprot id: A0A2K6PPI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

61622:SS18L2
gene id: 61622:SS18L2
uniprot id: A0A2K6R2H9
names: Similarity
messages: Belongs to the SS18 family.

61622:INIP
gene id: 61622:INIP
uniprot id: A0A2K6NQB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

61622:NHEJ1
gene id: 61622:NHEJ1
uniprot id: A0A2K6NYL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

61622:CRHR1
gene id: 61622:CRHR1
uniprot id: A0A2K6PDG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
messages: Membrane

61622:FUT9
gene id: 61622:FUT9
uniprot id: A0A2K6N9V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

61622:HEXB
gene id: 61622:HEXB
uniprot id: A0A2K6RB47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

61622:CFI
gene id: 61622:CFI
uniprot id: A0A2K6RMY1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PGGT1B
gene id: 61622:PGGT1B
uniprot id: A0A2K6PFI4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

61622:TMEM106C
gene id: 61622:TMEM106C
uniprot id: A0A2K6NLS7
names: Similarity
messages: Belongs to the TMEM106 family.

61622:EPHB1
gene id: 61622:EPHB1
uniprot id: A0A2K6NCC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

61622:ANO3
gene id: 61622:ANO3
uniprot id: A0A2K6PY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

61622:TSPO
gene id: 61622:TSPO
uniprot id: A0A2K6QYT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane
messages: Mitochondrion membrane

61622:ST6GALNAC4
gene id: 61622:ST6GALNAC4
uniprot id: A0A2K6Q6W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:MYRFL
gene id: 61622:MYRFL
uniprot id: A0A2K6RFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

61622:CSRNP1
gene id: 61622:CSRNP1
uniprot id: A0A2K6NA38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

61622:GJA5
gene id: 61622:GJA5
uniprot id: A0A2K6NRE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:FAM161A
gene id: 61622:FAM161A
uniprot id: A0A2K6QJ40
uniprot id: A0A2K6QJ41
names: Similarity
messages: Belongs to the FAM161 family.

61622:RAD51D
gene id: 61622:RAD51D
uniprot id: A0A2K6RMQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

61622:XYLB
gene id: 61622:XYLB
uniprot id: A0A2K6RGB9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

61622:NEIL3
gene id: 61622:NEIL3
uniprot id: A0A2K6N6Z3
names: Similarity
messages: Belongs to the FPG family.

61622:MRPS33
gene id: 61622:MRPS33
uniprot id: A0A2K6Q6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

61622:RAB27A
gene id: 61622:RAB27A
uniprot id: A0A2K6NY83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

61622:LOC104677083
gene id: 61622:LOC104677083
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LOC104680789
gene id: 61622:LOC104680789
uniprot id: A0A2K6NEH1
names: Similarity
messages: Belongs to the NDK family.

61622:CDS2
gene id: 61622:CDS2
uniprot id: A0A2K6QMH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

61622:CIAO2A
gene id: 61622:CIAO2A
uniprot id: A0A2K6PE14
uniprot id: A0A2K6PE31
names: Similarity
messages: Belongs to the MIP18 family.

61622:RPF1
gene id: 61622:RPF1
uniprot id: A0A2K6QIJ3
names: Subcellular Location Annotation
messages: nucleolus

61622:OTC
gene id: 61622:OTC
uniprot id: A0A2K6R482
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Homotrimer.

61622:ST13
gene id: 61622:ST13
uniprot id: A0A2K6PPW1
names: Similarity
messages: Belongs to the FAM10 family.

61622:NOP2
gene id: 61622:NOP2
uniprot id: A0A2K6R1W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

61622:EXOC4
gene id: 61622:EXOC4
uniprot id: A0A2K6NLF9
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61622:GFM1
gene id: 61622:GFM1
uniprot id: A0A2K6PAY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
messages: Mitochondrion

61622:PIP
gene id: 61622:PIP
uniprot id: A0A2K6P4B7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.
messages: Secreted

61622:UBP1
gene id: 61622:UBP1
uniprot id: A0A2K6PBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61622:TENM2
gene id: 61622:TENM2
uniprot id: A0A2K6Q1G3
uniprot id: A0A2K6Q1G7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family. Teneurin subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:MAPK7
gene id: 61622:MAPK7
uniprot id: A0A2K6RJY3
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

61622:WASL
gene id: 61622:WASL
uniprot id: A0A2K6QN01
names: Subcellular Location Annotation
messages: Nucleus

61622:F9
gene id: 61622:F9
uniprot id: A0A2K6QEI5
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:FHL5
gene id: 61622:FHL5
uniprot id: A0A2K6R4W7
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

61622:CLU
gene id: 61622:CLU
uniprot id: A0A2K6R0L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

61622:SHMT1
gene id: 61622:SHMT1
uniprot id: A0A2K6Q4D7
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

61622:NARF
gene id: 61622:NARF
uniprot id: A0A2K6NF76
names: Similarity
messages: Belongs to the NARF family.

61622:MYO1F
gene id: 61622:MYO1F
uniprot id: A0A2K6R0P4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:TMEM170B
gene id: 61622:TMEM170B
uniprot id: A0A2K6NHN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

61622:MYO1E
gene id: 61622:MYO1E
uniprot id: A0A2K6PT66
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:KARS1
gene id: 61622:KARS1
uniprot id: A0A2K6R4H9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:UNC5D
gene id: 61622:UNC5D
uniprot id: A0A2K6RUE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

61622:PKNOX1
gene id: 61622:PKNOX1
uniprot id: A0A2K6Q9Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

61622:KCTD18
gene id: 61622:KCTD18
uniprot id: A0A2K6RJD1
names: Subcellular Location Annotation
messages: Cell membrane

61622:NLRP13
gene id: 61622:NLRP13
uniprot id: A0A2K6R3Q9
names: Similarity
messages: Belongs to the NLRP family.

61622:TPRKB
gene id: 61622:TPRKB
uniprot id: A0A2K6Q6P3
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

61622:LOC104681237
gene id: 61622:LOC104681237
uniprot id: A0A2K6NLV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:UBE2A
gene id: 61622:UBE2A
uniprot id: A0A2K6RLE9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:GRM5
gene id: 61622:GRM5
uniprot id: A0A2K6R3P5
uniprot id: A0A2K6R3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

61622:PSMG2
gene id: 61622:PSMG2
uniprot id: A0A2K6NKI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

61622:PLPP3
gene id: 61622:PLPP3
uniprot id: A0A2K6RF46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:RABEP2
gene id: 61622:RABEP2
uniprot id: A0A2K6RA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rabaptin family.
messages: Early endosome
messages: Endosome
messages: centrosome
messages: cilium basal body

61622:LOC104658884
gene id: 61622:LOC104658884
uniprot id: A0A2K6RRT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:INS
gene id: 61622:INS
uniprot id: A0A2K6R041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

61622:CDKAL1
gene id: 61622:CDKAL1
uniprot id: A0A2K6RBS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

61622:TAS1R2
gene id: 61622:TAS1R2
uniprot id: A0A0M4PM72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:GALNT11
gene id: 61622:GALNT11
uniprot id: A0A2K6QZA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:PNPT1
gene id: 61622:PNPT1
uniprot id: A0A2K6QYS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm

61622:RRAD
gene id: 61622:RRAD
uniprot id: A0A2K6QIG2
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61622:MZT1
gene id: 61622:MZT1
uniprot id: A0A2K6QL96
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

61622:VARS1
gene id: 61622:VARS1
uniprot id: A0A2K6RVU0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:GLP2R
gene id: 61622:GLP2R
uniprot id: A0A2K6Q8G1
names: Subcellular Location Annotation
messages: Membrane

61622:CD46
gene id: 61622:CD46
uniprot id: A0A2K6RJJ8
uniprot id: A0A2K6RJK7
uniprot id: A0A2K6RJN7
uniprot id: A0A2K6RJP1
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: acrosome inner membrane

61622:CCL15
gene id: 61622:CCL15
uniprot id: A0A2K6R6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:DEFB125
gene id: 61622:DEFB125
uniprot id: A0A2K6NC29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:PARP6
gene id: 61622:PARP6
uniprot id: A0A2K6QLA7
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:MED20
gene id: 61622:MED20
uniprot id: A0A2K6RRF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:CADM3
gene id: 61622:CADM3
uniprot id: A0A2K6QL41
uniprot id: A0A2K6QL53
names: Similarity
messages: Belongs to the nectin family.

61622:IVD
gene id: 61622:IVD
uniprot id: A0A2K6NB55
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:TRIM25
gene id: 61622:TRIM25
uniprot id: A0A2K6QC67
names: Similarity
messages: Belongs to the TRIM/RBCC family.

61622:SLC35B2
gene id: 61622:SLC35B2
uniprot id: A0A2K6PK82
uniprot id: A0A2K6PKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

61622:BICD2
gene id: 61622:BICD2
uniprot id: A0A2K6PZY9
uniprot id: A0A2K6Q004
names: Similarity
messages: Belongs to the BicD family.

61622:MAL2
gene id: 61622:MAL2
uniprot id: A0A2K6RXW1
names: Subcellular Location Annotation
messages: Membrane

61622:TNFRSF10B
gene id: 61622:TNFRSF10B
uniprot id: A0A2K6NKZ4
uniprot id: A0A2K6NL00
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

61622:VPS29
gene id: 61622:VPS29
uniprot id: A0A2K6PSS4
uniprot id: A0A2K6PSS9
uniprot id: A0A2K6PST2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

61622:PEX13
gene id: 61622:PEX13
uniprot id: A0A2K6PCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

61622:ESYT3
gene id: 61622:ESYT3
uniprot id: A0A2K6R2G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:GRIN2A
gene id: 61622:GRIN2A
uniprot id: A0A2K6RR41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:ECSIT
gene id: 61622:ECSIT
uniprot id: A0A2K6PZ15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the ECSIT family.
messages: Cytoplasm
messages: Mitochondrion
messages: Nucleus

61622:OTOA
gene id: 61622:OTOA
uniprot id: A0A2K6PNL0
names: Similarity
messages: Belongs to the mesothelin family.

61622:CAPN7
gene id: 61622:CAPN7
uniprot id: A0A2K6PIY4
names: Similarity
messages: Belongs to the peptidase C2 family.

61622:ABHD1
gene id: 61622:ABHD1
uniprot id: A0A2K6NXD4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

61622:THOC7
gene id: 61622:THOC7
uniprot id: A0A2K6ND57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC7 family.
messages: Nucleus
messages: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

61622:PPP2R5A
gene id: 61622:PPP2R5A
uniprot id: A0A2K6NQ77
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

61622:IGFL3
gene id: 61622:IGFL3
uniprot id: A0A2K6QTP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

61622:LOC104661449
gene id: 61622:LOC104661449
uniprot id: A0A2K6N9R0
names: Similarity
messages: Belongs to the FAH family.

61622:SPON2
gene id: 61622:SPON2
uniprot id: A0A2K6PZ73
names: Subcellular Location Annotation
messages: extracellular matrix

61622:TCTA
gene id: 61622:TCTA
uniprot id: A0A2K6QKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTA family.
messages: May be required for cellular fusion during osteoclastogenesis.
messages: Membrane

61622:TMEM161B
gene id: 61622:TMEM161B
uniprot id: A0A2K6R9F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

61622:ELF1
gene id: 61622:ELF1
uniprot id: A0A2K6QFA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:CPSF4L
gene id: 61622:CPSF4L
uniprot id: A0A2K6QCV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

61622:C13H22orf39
gene id: 61622:C13H22orf39
uniprot id: A0A2K6Q067
names: Similarity
messages: Belongs to the UPF0545 family.

61622:STAR
gene id: 61622:STAR
uniprot id: A0A2K6N6Y3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

61622:MEGF11
gene id: 61622:MEGF11
uniprot id: A0A2K6NQL3
uniprot id: A0A2K6NQM6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NAB2
gene id: 61622:NAB2
uniprot id: A0A2K6R0L5
uniprot id: A0A2K6R0L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

61622:FBLN5
gene id: 61622:FBLN5
uniprot id: A0A2K6P9B9
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RBM48
gene id: 61622:RBM48
uniprot id: A0A2K6QK98
names: Similarity
messages: Belongs to the RBM48 family.

61622:PSPH
gene id: 61622:PSPH
uniprot id: A0A2K6Q4V0
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

61622:CFAP45
gene id: 61622:CFAP45
uniprot id: A0A2K6PGJ8
names: Similarity
messages: Belongs to the CFAP45 family.

61622:EPN1
gene id: 61622:EPN1
uniprot id: A0A2K6QKR7
uniprot id: A0A2K6QKS3
names: Similarity
messages: Belongs to the epsin family.

61622:IZUMO4
gene id: 61622:IZUMO4
uniprot id: A0A2K6R9Y0
names: Similarity
messages: Belongs to the Izumo family.

61622:ATG2A
gene id: 61622:ATG2A
uniprot id: A0A2K6NP93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

61622:TPM1
gene id: 61622:TPM1
uniprot id: A0A2K6NW93
uniprot id: A0A2K6NW95
uniprot id: A0A2K6NWA5
uniprot id: A0A2K6NWB5
uniprot id: A0A2K6NWB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

61622:TRIM36
gene id: 61622:TRIM36
uniprot id: A0A2K6QYR1
uniprot id: A0A2K6QYU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus
messages: cytoskeleton

61622:SLC30A8
gene id: 61622:SLC30A8
uniprot id: A0A2K6R9W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Cell membrane
messages: Membrane
messages: secretory vesicle membrane

61622:NPPC
gene id: 61622:NPPC
uniprot id: A0A2K6RSS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

61622:FGF20
gene id: 61622:FGF20
uniprot id: A0A2K6P4K8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:GATA2
gene id: 61622:GATA2
uniprot id: A0A2K6RED9
names: Subcellular Location Annotation
messages: Nucleus

61622:RPE
gene id: 61622:RPE
uniprot id: A0A2K6PD48
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

61622:DNAJC22
gene id: 61622:DNAJC22
uniprot id: A0A2K6R7T7
names: Function
names: Subcellular Location Annotation
messages: May function as a co-chaperone.
messages: Membrane

61622:MPPED2
gene id: 61622:MPPED2
uniprot id: A0A2K6PMT4
names: Similarity
messages: Belongs to the UPF0046 family.

61622:BLOC1S5
gene id: 61622:BLOC1S5
uniprot id: A0A2K6RI05
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

61622:MAP2K3
gene id: 61622:MAP2K3
uniprot id: A0A2K6Q8E2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:PRR15L
gene id: 61622:PRR15L
uniprot id: A0A2K6NDI2
names: Similarity
messages: Belongs to the PRR15 family.

61622:PDE8A
gene id: 61622:PDE8A
uniprot id: A0A2K6PBG7
uniprot id: A0A2K6PBJ7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:SORCS2
gene id: 61622:SORCS2
uniprot id: A0A2K6QJE1
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

61622:LOC104665155
gene id: 61622:LOC104665155
uniprot id: A0A2K6N9T1
names: Similarity
messages: Belongs to the folate receptor family.

61622:STAB1
gene id: 61622:STAB1
uniprot id: A0A2K6PIM0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SSX2IP
gene id: 61622:SSX2IP
uniprot id: A0A2K6RFT0
uniprot id: A0A2K6RFU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

61622:VPS4B
gene id: 61622:VPS4B
uniprot id: A0A2K6QXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:RDX
gene id: 61622:RDX
uniprot id: A0A2K6Q7H4
uniprot id: A0A2K6Q7I2
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61622:TRIM5
gene id: 61622:TRIM5
uniprot id: A0A2K6QBL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

61622:BOD1
gene id: 61622:BOD1
uniprot id: A0A2K6QSC2
uniprot id: A0A2K6QSE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

61622:SGCG
gene id: 61622:SGCG
uniprot id: A0A2K6NXY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

61622:TRIM3
gene id: 61622:TRIM3
uniprot id: A0A2K6QU30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Cytoplasm
messages: Nucleus

61622:NOP14
gene id: 61622:NOP14
uniprot id: A0A2K6RXF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

61622:CD93
gene id: 61622:CD93
uniprot id: A0A2K6NFH6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:KCNA6
gene id: 61622:KCNA6
uniprot id: A0A2K6NMN7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:DIS3L
gene id: 61622:DIS3L
uniprot id: A0A2K6QJT9
uniprot id: A0A2K6QJW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
messages: Cytoplasm
messages: Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.

61622:C20H16orf58
gene id: 61622:C20H16orf58
uniprot id: A0A2K6RS71
names: Similarity
messages: Belongs to the RUS1 family.

61622:IMPACT
gene id: 61622:IMPACT
uniprot id: A0A2K6QJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

61622:UTP23
gene id: 61622:UTP23
uniprot id: A0A2K6NVF9
names: Subcellular Location Annotation
messages: nucleolus

61622:HNRNPA3
gene id: 61622:HNRNPA3
uniprot id: A0A2K6NWS1
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104681097
gene id: 61622:LOC104681097
uniprot id: A0A2K6NRI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:POFUT1
gene id: 61622:POFUT1
uniprot id: A0A2K6PK98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 65 family.
messages: Endoplasmic reticulum

61622:LOC104654195
gene id: 61622:LOC104654195
uniprot id: A0A2K6PIK4
names: Similarity
messages: Belongs to the COX20 family.

61622:RAB33B
gene id: 61622:RAB33B
uniprot id: A0A2K6PTX4
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

61622:KATNB1
gene id: 61622:KATNB1
uniprot id: A0A2K6RDY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome. This interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1. Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

61622:FTSJ3
gene id: 61622:FTSJ3
uniprot id: A0A2K6RSK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Interacts with NIP7.
messages: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
messages: nucleolus

61622:HCST
gene id: 61622:HCST
uniprot id: A0A2K6PDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAP10 family.
messages: Membrane

61622:LOC104667031
gene id: 61622:LOC104667031
uniprot id: A0A2K6QEQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:CSF1R
gene id: 61622:CSF1R
uniprot id: A0A2K6ND50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

61622:ITIH5
gene id: 61622:ITIH5
uniprot id: A0A2K6PX48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

61622:OLFM3
gene id: 61622:OLFM3
uniprot id: A0A2K6QU11
uniprot id: A0A2K6QU42
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61622:TCAF1
gene id: 61622:TCAF1
uniprot id: A0A2K6RFE8
uniprot id: A0A2K6RFF6
names: Similarity
messages: Belongs to the TCAF family.

61622:TRIP13
gene id: 61622:TRIP13
uniprot id: A0A2K6RDV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

61622:AGAP1
gene id: 61622:AGAP1
uniprot id: A0A2K6Q7R5
names: Similarity
messages: Belongs to the centaurin gamma-like family.

61622:TRPT1
gene id: 61622:TRPT1
uniprot id: A0A2K6RRZ9
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

61622:LOC104681218
gene id: 61622:LOC104681218
uniprot id: A0A2K6QYM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

61622:NELFE
gene id: 61622:NELFE
uniprot id: A0A2K6R7X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NELF-E family.
messages: Chromosome
messages: Nucleus

61622:PIGP
gene id: 61622:PIGP
uniprot id: A0A2K6QAI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGP family.
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

61622:REN
gene id: 61622:REN
uniprot id: A0A2K6P8F8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A1 family.
messages: Interacts with ATP6AP2.
messages: Membrane
messages: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
messages: Secreted

61622:FAM49B
gene id: 61622:FAM49B
uniprot id: A0A2K6QBN4
uniprot id: A0A2K6QBQ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

61622:SLC16A7
gene id: 61622:SLC16A7
uniprot id: A0A2K6RP61
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

61622:LOC104657623
gene id: 61622:LOC104657623
uniprot id: A0A2K6QHA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

61622:CFAP206
gene id: 61622:CFAP206
uniprot id: A0A2K6NF16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

61622:LIPH
gene id: 61622:LIPH
uniprot id: A0A2K6RSX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

61622:NKX3-1
gene id: 61622:NKX3-1
uniprot id: A0A2K6Q3L9
names: Subcellular Location Annotation
messages: Nucleus

61622:TMTC3
gene id: 61622:TMTC3
uniprot id: A0A2K6NSI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

61622:HOXB9
gene id: 61622:HOXB9
uniprot id: A0A2K6RQ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

61622:ENTPD4
gene id: 61622:ENTPD4
uniprot id: A0A2K6NKX2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:ADORA1
gene id: 61622:ADORA1
uniprot id: A0A2K6NX56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

61622:POLR3GL
gene id: 61622:POLR3GL
uniprot id: A0A2K6RDL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61622:CAV3
gene id: 61622:CAV3
uniprot id: A0A2K6NIN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola
messages: sarcolemma

61622:MED18
gene id: 61622:MED18
uniprot id: A0A2K6Q9E5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:INPPL1
gene id: 61622:INPPL1
uniprot id: A0A2K6P7Z9
names: Similarity
names: Subcellular Location Annotation
messages: Basal cell membrane
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane
messages: Nucleus speckle
messages: filopodium
messages: lamellipodium
messages: spindle pole

61622:SPG7
gene id: 61622:SPG7
uniprot id: A0A2K6RX13
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

61622:GJB5
gene id: 61622:GJB5
uniprot id: A0A2K6NHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:ATP13A3
gene id: 61622:ATP13A3
uniprot id: A0A2K6NA53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

61622:UPP1
gene id: 61622:UPP1
uniprot id: A0A2K6RM06
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

61622:RDH14
gene id: 61622:RDH14
uniprot id: A0A2K6Q4Q1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:TM4SF4
gene id: 61622:TM4SF4
uniprot id: A0A2K6NEB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:SLC43A2
gene id: 61622:SLC43A2
uniprot id: A0A2K6RTU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC43A transporter (TC 2.A.1.44) family.
messages: Membrane

61622:SUDS3
gene id: 61622:SUDS3
uniprot id: A0A2K6R6I1
names: Subcellular Location Annotation
messages: Nucleus

61622:MED9
gene id: 61622:MED9
uniprot id: A0A2K6RCW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:SLC17A1
gene id: 61622:SLC17A1
uniprot id: A0A2K6RBR9
uniprot id: A0A2K6RBY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
messages: Membrane

61622:RDH13
gene id: 61622:RDH13
uniprot id: A0A2K6R3C0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:CNOT2
gene id: 61622:CNOT2
uniprot id: A0A2K6RBW5
uniprot id: A0A2K6RBY3
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

61622:OSBPL8
gene id: 61622:OSBPL8
uniprot id: A0A2K6RBD6
uniprot id: A0A2K6RBF4
names: Similarity
messages: Belongs to the OSBP family.

61622:SRSF2
gene id: 61622:SRSF2
uniprot id: A0A2K6RAS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

61622:SPX
gene id: 61622:SPX
uniprot id: A0A2K6NIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spexin family.
messages: Secreted

61622:TRMT6
gene id: 61622:TRMT6
uniprot id: A0A2K6RUR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

61622:NUP88
gene id: 61622:NUP88
uniprot id: A0A2K6RI42
names: Subcellular Location Annotation
messages: nuclear pore complex

61622:UTP11
gene id: 61622:UTP11
uniprot id: A0A2K6NFE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

61622:LHFPL4
gene id: 61622:LHFPL4
uniprot id: A0A2K6PZB6
names: Subcellular Location Annotation
messages: Membrane

61622:GDF10
gene id: 61622:GDF10
uniprot id: A0A2K6PZF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

61622:LEO1
gene id: 61622:LEO1
uniprot id: A0A2K6Q8X4
names: Similarity
messages: Belongs to the LEO1 family.

61622:LOC104664033
gene id: 61622:LOC104664033
uniprot id: A0A2K6PYL5
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:NSMCE2
gene id: 61622:NSMCE2
uniprot id: A0A2K6QFC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

61622:PSMC4
gene id: 61622:PSMC4
uniprot id: A0A2K6QD83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
messages: Cytoplasm

61622:GPR4
gene id: 61622:GPR4
uniprot id: A0A2K6NKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ACSL1
gene id: 61622:ACSL1
uniprot id: A0A2K6R4Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

61622:PSMD8
gene id: 61622:PSMD8
uniprot id: A0A2K6NI35
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

61622:PTPN21
gene id: 61622:PTPN21
uniprot id: A0A2K6P1K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

61622:FAXC
gene id: 61622:FAXC
uniprot id: A0A2K6RCN9
names: Similarity
messages: Belongs to the FAX family.

61622:DHX29
gene id: 61622:DHX29
uniprot id: A0A2K6RL88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Cytoplasm
messages: Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

61622:GRK2
gene id: 61622:GRK2
uniprot id: A0A2K6PMB5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

61622:PSMB7
gene id: 61622:PSMB7
uniprot id: A0A2K6RGC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

61622:NNAT
gene id: 61622:NNAT
uniprot id: A0A2K6QTL5
uniprot id: A0A2K6QTP1
names: Similarity
messages: Belongs to the neuronatin family.

61622:USP33
gene id: 61622:USP33
uniprot id: A0A2K6NFP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP20/USP33 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: centrosome
messages: perinuclear region

61622:KDM1A
gene id: 61622:KDM1A
uniprot id: A0A2K6R0R4
uniprot id: A0A2K6R0V7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavin monoamine oxidase family.
messages: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
messages: Nucleus
messages: The SWIRM domain may act as an anchor site for a histone tail.

61622:LOC104676364
gene id: 61622:LOC104676364
uniprot id: A0A2K6NLA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

61622:WDYHV1
gene id: 61622:WDYHV1
uniprot id: A0A2K6PB79
uniprot id: A0A2K6PB92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NTAQ1 family.
messages: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
messages: Monomer.

61622:LRP6
gene id: 61622:LRP6
uniprot id: A0A2K6RE06
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ST8SIA1
gene id: 61622:ST8SIA1
uniprot id: A0A2K6NZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:KCND1
gene id: 61622:KCND1
uniprot id: A0A2K6RLU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

61622:LOC104681253
gene id: 61622:LOC104681253
uniprot id: A0A2K6NC87
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

61622:OTX1
gene id: 61622:OTX1
uniprot id: A0A2K6QK07
names: Subcellular Location Annotation
messages: Nucleus

61622:MNAT1
gene id: 61622:MNAT1
uniprot id: A0A2K6Q4S8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with CDK7 and cyclin H.
messages: Nucleus
messages: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.

61622:NXT2
gene id: 61622:NXT2
uniprot id: A0A2K6Q7Z4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

61622:LOC104676508
gene id: 61622:LOC104676508
uniprot id: A0A2K6NXG6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:FOXP4
gene id: 61622:FOXP4
uniprot id: A0A2K6RGU7
names: Subcellular Location Annotation
messages: Nucleus

61622:CASS4
gene id: 61622:CASS4
uniprot id: A0A2K6R7I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61622:KCNK10
gene id: 61622:KCNK10
uniprot id: A0A2K6NN39
uniprot id: A0A2K6NN71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:ALG8
gene id: 61622:ALG8
uniprot id: A0A2K6QEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:GFOD1
gene id: 61622:GFOD1
uniprot id: A0A2K6QYY6
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

61622:HOXA5
gene id: 61622:HOXA5
uniprot id: A0A2K6NTU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:LARS2
gene id: 61622:LARS2
uniprot id: A0A2K6RI47
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:ARRDC4
gene id: 61622:ARRDC4
uniprot id: A0A2K6NFM3
names: Similarity
messages: Belongs to the arrestin family.

61622:MSH4
gene id: 61622:MSH4
uniprot id: A0A2K6QXX7
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

61622:LOC104655815
gene id: 61622:LOC104655815
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:VPS52
gene id: 61622:VPS52
uniprot id: A0A2K6QSF3
names: Similarity
messages: Belongs to the VPS52 family.

61622:PDCL3
gene id: 61622:PDCL3
uniprot id: A0A2K6Q189
names: Similarity
messages: Belongs to the phosducin family.

61622:SAE1
gene id: 61622:SAE1
uniprot id: A0A2K6PF78
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

61622:TMEM39A
gene id: 61622:TMEM39A
uniprot id: A0A2K6P087
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

61622:PRM2
gene id: 61622:PRM2
uniprot id: A0A2K6R0M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protamine P2 family.
messages: Interacts with TDRP.
messages: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

61622:PFKFB2
gene id: 61622:PFKFB2
uniprot id: A0A2K6QGI0
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

61622:PPP1R15A
gene id: 61622:PPP1R15A
uniprot id: A0A2K6RIN8
names: Similarity
messages: Belongs to the PPP1R15 family.

61622:SLC5A7
gene id: 61622:SLC5A7
uniprot id: A0A2K6PUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:EIF5A
gene id: 61622:EIF5A
uniprot id: A0A2K6QYK5
uniprot id: A0A2K6QYN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

61622:DYNC1LI1
gene id: 61622:DYNC1LI1
uniprot id: A0A2K6P7H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

61622:TUT4
gene id: 61622:TUT4
uniprot id: A0A2K6PZI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

61622:RSPO1
gene id: 61622:RSPO1
uniprot id: A0A2K6R796
names: Similarity
messages: Belongs to the R-spondin family.

61622:SPIB
gene id: 61622:SPIB
uniprot id: A0A2K6QNS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:LIPM
gene id: 61622:LIPM
uniprot id: A0A2K6PS08
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:PIGV
gene id: 61622:PIGV
uniprot id: A0A2K6RT85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

61622:TFB1M
gene id: 61622:TFB1M
uniprot id: A0A2K6PSU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.
messages: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

61622:ZCCHC17
gene id: 61622:ZCCHC17
uniprot id: A0A2K6NX78
uniprot id: A0A2K6NX89
names: Subcellular Location Annotation
messages: nucleolus

61622:LOC104664126
gene id: 61622:LOC104664126
uniprot id: A0A2K6QT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:SLC12A2
gene id: 61622:SLC12A2
uniprot id: A0A2K6PLM2
uniprot id: A0A2K6PLM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

61622:TWF1
gene id: 61622:TWF1
uniprot id: A0A2K6QNB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

61622:YPEL2
gene id: 61622:YPEL2
uniprot id: A0A2K6PZ62
names: Similarity
messages: Belongs to the yippee family.

61622:CFTR
gene id: 61622:CFTR
uniprot id: A0A2K6NRS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
messages: Monomer; does not require oligomerization for channel activity. May form oligomers in the membrane (By similarity). Interacts with SLC26A3, SLC26A6 and SLC9A3R1 (By similarity). Interacts with SHANK2 (By similarity). Interacts with MYO6 (By similarity). Interacts (via C-terminus) with GOPC (via PDZ domain); this promotes CFTR internalization and thereby decreases channel activity. Interacts with SLC4A7 through SLC9A3R1. Found in a complex with MYO5B and RAB11A. Interacts with ANO1. Interacts with SLC26A8 (By similarity). Interacts with AHCYL1; the interaction increases CFTR activity (By similarity). Interacts with CSE1L (By similarity). The core-glycosylated form interacts with GORASP2 (via PDZ GRASP-type 1 domain) in respone to ER stress (By similarity). Interacts with MARCHF2; the interaction leads to CFTR ubiqtuitination and degradation.
messages: Recycling endosome membrane

61622:PGC
gene id: 61622:PGC
uniprot id: A0A2K6QZ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Hydrolyzes a variety of proteins.
messages: Secreted

61622:TMEM120A
gene id: 61622:TMEM120A
uniprot id: A0A2K6PYZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

61622:NTF4
gene id: 61622:NTF4
uniprot id: A0A2K6NLS5
names: Similarity
messages: Belongs to the NGF-beta family.

61622:LVRN
gene id: 61622:LVRN
uniprot id: A0A2K6QC13
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:BSX
gene id: 61622:BSX
uniprot id: A0A2K6PCS4
names: Subcellular Location Annotation
messages: Nucleus

61622:GALNT2
gene id: 61622:GALNT2
uniprot id: A0A2K6QYI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:SMIM24
gene id: 61622:SMIM24
uniprot id: A0A2K6PMJ6
names: Subcellular Location Annotation
messages: Membrane

61622:DMRTB1
gene id: 61622:DMRTB1
uniprot id: A0A2K6PA18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:NR1D1
gene id: 61622:NR1D1
uniprot id: A0A2K6NN05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:NOB1
gene id: 61622:NOB1
uniprot id: A0A2K6PQG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: May play a role in mRNA degradation.
messages: Nucleus

61622:ZSCAN20
gene id: 61622:ZSCAN20
uniprot id: A0A2K6Q586
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:TMEM59L
gene id: 61622:TMEM59L
uniprot id: A0A2K6NNS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:SLC44A1
gene id: 61622:SLC44A1
uniprot id: A0A2K6RBY1
uniprot id: A0A2K6RC49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

61622:ANXA7
gene id: 61622:ANXA7
uniprot id: A0A2K6QHP4
uniprot id: A0A2K6QHP6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61622:LOC104658131
gene id: 61622:LOC104658131
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:SOD3
gene id: 61622:SOD3
uniprot id: A0A2K6NKP3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

61622:PPIE
gene id: 61622:PPIE
uniprot id: A0A2K6RS34
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
messages: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

61622:CBLB
gene id: 61622:CBLB
uniprot id: A0A2K6RJ27
uniprot id: A0A2K6RJ34
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

61622:SLC2A13
gene id: 61622:SLC2A13
uniprot id: A0A2K6P3L8
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:PRKAG1
gene id: 61622:PRKAG1
uniprot id: A0A2K6QG94
uniprot id: A0A2K6QG99
names: Similarity
names: Subunit
messages: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
messages: Belongs to the 5'-AMP-activated protein kinase gamma subunit family.

61622:IL7R
gene id: 61622:IL7R
uniprot id: A0A2K6QXN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

61622:RPL9
gene id: 61622:RPL9
uniprot id: A0A2K6NGZ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

61622:GNPTAB
gene id: 61622:GNPTAB
uniprot id: A0A2K6QKG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

61622:WNT3A
gene id: 61622:WNT3A
uniprot id: A0A2K6QGF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:TMOD4
gene id: 61622:TMOD4
uniprot id: A0A2K6QWA7
names: Subcellular Location Annotation
messages: cytoskeleton

61622:PROX2
gene id: 61622:PROX2
uniprot id: A0A2K6PU03
uniprot id: A0A2K6PU14
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104676553
gene id: 61622:LOC104676553
uniprot id: A0A2K6NAJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

61622:ATAD2
gene id: 61622:ATAD2
uniprot id: A0A2K6NWC8
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:HGD
gene id: 61622:HGD
uniprot id: A0A2K6P4V3
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

61622:AKR1B1
gene id: 61622:AKR1B1
uniprot id: A0A2K6QZ33
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:CUEDC2
gene id: 61622:CUEDC2
uniprot id: A0A2K6RMA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

61622:NCDN
gene id: 61622:NCDN
uniprot id: A0A2K6RCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

61622:LOC104674497
gene id: 61622:LOC104674497
uniprot id: A0A2K6Q483
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

61622:LOC104663917
gene id: 61622:LOC104663917
uniprot id: A0A2K6QER2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

61622:GYS1
gene id: 61622:GYS1
uniprot id: A0A2K6PY65
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

61622:LOC104664525
gene id: 61622:LOC104664525
uniprot id: A0A2K6P2F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61622:LOC104657073
gene id: 61622:LOC104657073
uniprot id: A0A2K6P3C7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:FGF3
gene id: 61622:FGF3
uniprot id: A0A2K6RH60
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:TMEM59
gene id: 61622:TMEM59
uniprot id: A0A2K6Q531
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:PEX2
gene id: 61622:PEX2
uniprot id: A0A2K6NI76
names: Function
names: Similarity
messages: Belongs to the pex2/pex10/pex12 family.
messages: Somewhat implicated in the biogenesis of peroxisomes.

61622:STAC2
gene id: 61622:STAC2
uniprot id: A0A2K6RUQ9
names: Subcellular Location Annotation
messages: sarcolemma

61622:KRT24
gene id: 61622:KRT24
uniprot id: A0A2K6NEL6
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SDR16C5
gene id: 61622:SDR16C5
uniprot id: A0A2K6RXS7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:SAR1A
gene id: 61622:SAR1A
uniprot id: A0A2K6RLV2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

61622:ALG2
gene id: 61622:ALG2
uniprot id: A0A2K6PFF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

61622:ITPA
gene id: 61622:ITPA
uniprot id: A0A2K6PX05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

61622:OSBP
gene id: 61622:OSBP
uniprot id: A0A2K6RKN0
names: Similarity
messages: Belongs to the OSBP family.

61622:PROM1
gene id: 61622:PROM1
uniprot id: A0A2K6R2S4
uniprot id: A0A2K6R2S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

61622:MPP5
gene id: 61622:MPP5
uniprot id: A0A2K6PHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: tight junction

61622:VPS11
gene id: 61622:VPS11
uniprot id: A0A2K6QJ60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS11 family.
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: autophagosome
messages: clathrin-coated vesicle

61622:SERPINB5
gene id: 61622:SERPINB5
uniprot id: A0A2K6RRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family. Ov-serpin subfamily.
messages: extracellular space

61622:SPTBN1
gene id: 61622:SPTBN1
uniprot id: A0A2K6Q0J9
uniprot id: A0A2K6Q0L4
names: Similarity
messages: Belongs to the spectrin family.

61622:PTPRG
gene id: 61622:PTPRG
uniprot id: A0A2K6R724
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
messages: Membrane

61622:EPYC
gene id: 61622:EPYC
uniprot id: A0A2K6NL33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: extracellular matrix

61622:PNPLA4
gene id: 61622:PNPLA4
uniprot id: A0A2K6P2A7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:IL12RB2
gene id: 61622:IL12RB2
uniprot id: A0A2K6QN80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61622:FAM160A1
gene id: 61622:FAM160A1
uniprot id: A0A2K6PBE0
names: Similarity
messages: Belongs to the FHIP family.

61622:CDCA5
gene id: 61622:CDCA5
uniprot id: A0A2K6PUX5
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61622:LAMP5
gene id: 61622:LAMP5
uniprot id: A0A2K6P4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

61622:CDC25B
gene id: 61622:CDC25B
uniprot id: A0A2K6Q6L6
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

61622:EFNA3
gene id: 61622:EFNA3
uniprot id: A0A2K6P8G2
uniprot id: A0A2K6P8M5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PUS1
gene id: 61622:PUS1
uniprot id: A0A2K6QTP6
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

61622:LOC104663264
gene id: 61622:LOC104663264
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:SAA4
gene id: 61622:SAA4
uniprot id: A0A2K6R5W5
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

61622:KMO
gene id: 61622:KMO
uniprot id: A0A2K6QI22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
messages: Mitochondrion outer membrane

61622:PGAM2
gene id: 61622:PGAM2
uniprot id: A0A2K6QS81
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:STRN3
gene id: 61622:STRN3
uniprot id: A0A2K6RR65
uniprot id: A0A2K6RR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

61622:CKAP5
gene id: 61622:CKAP5
uniprot id: A0A2K6QUH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOG/XMAP215 family.
messages: kinetochore

61622:SQLE
gene id: 61622:SQLE
uniprot id: A0A2K6PHV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

61622:GLS2
gene id: 61622:GLS2
uniprot id: A0A2K6PZW3
names: Similarity
messages: Belongs to the glutaminase family.

61622:RNF8
gene id: 61622:RNF8
uniprot id: A0A2K6RA02
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

61622:DPH2
gene id: 61622:DPH2
uniprot id: A0A2K6RSU3
uniprot id: A0A2K6RSV4
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

61622:ACAT2
gene id: 61622:ACAT2
uniprot id: A0A2K6P8X7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61622:LOC104657701
gene id: 61622:LOC104657701
uniprot id: A0A2K6QDL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:UFD1
gene id: 61622:UFD1
uniprot id: A0A2K6QJY3
names: Similarity
messages: Belongs to the UFD1 family.

61622:MRPS5
gene id: 61622:MRPS5
uniprot id: A0A2K6QEE0
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

61622:CBS
gene id: 61622:CBS
uniprot id: A0A2K6NK06
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

61622:RPS6KB1
gene id: 61622:RPS6KB1
uniprot id: A0A2K6R1V3
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61622:MTERF2
gene id: 61622:MTERF2
uniprot id: A0A2K6NA57
names: Similarity
messages: Belongs to the mTERF family.

61622:LYAR
gene id: 61622:LYAR
uniprot id: A0A2K6PWN6
uniprot id: A0A2K6PWN8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:FBN1
gene id: 61622:FBN1
uniprot id: A0A2K6QFN9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fibrillin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:SEPTIN9
gene id: 61622:SEPTIN9
uniprot id: A0A2K6R1L3
uniprot id: A0A2K6R1N3
uniprot id: A0A2K6R1R7
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

61622:PEA15
gene id: 61622:PEA15
uniprot id: A0A2K6Q677
names: Subcellular Location Annotation
messages: Cytoplasm

61622:MAP3K14
gene id: 61622:MAP3K14
uniprot id: A0A2K6PY40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

61622:DLX2
gene id: 61622:DLX2
uniprot id: A0A2K6PLA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

61622:FGGY
gene id: 61622:FGGY
uniprot id: A0A2K6NWC5
names: Similarity
messages: Belongs to the FGGY kinase family.

61622:TMEM183A
gene id: 61622:TMEM183A
uniprot id: A0A2K6QVX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM183 family.
messages: Membrane

61622:LOC104669807
gene id: 61622:LOC104669807
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:BLVRA
gene id: 61622:BLVRA
uniprot id: A0A2K6PZL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
messages: Monomer.
messages: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
messages: cytosol

61622:VGLL1
gene id: 61622:VGLL1
uniprot id: A0A2K6NGU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

61622:MED8
gene id: 61622:MED8
uniprot id: A0A2K6P048
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:SLC5A9
gene id: 61622:SLC5A9
uniprot id: A0A2K6RMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:CFH
gene id: 61622:CFH
uniprot id: A0A2K6PRN7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TMEM11
gene id: 61622:TMEM11
uniprot id: A0A2K6NVN7
uniprot id: A0A2K6NVP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM11 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in mitochondrial morphogenesis.

61622:LOC104666619
gene id: 61622:LOC104666619
uniprot id: A0A2K6N6Y1
names: Similarity
messages: Belongs to the MHC class II family.

61622:TMEM115
gene id: 61622:TMEM115
uniprot id: A0A2K6P9H0
names: Subcellular Location Annotation
messages: Membrane

61622:MMP26
gene id: 61622:MMP26
uniprot id: A0A2K6PFU2
names: Similarity
messages: Belongs to the peptidase M10A family.

61622:PRL
gene id: 61622:PRL
uniprot id: A0A2K6PLN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

61622:SERP1
gene id: 61622:SERP1
uniprot id: A0A2K6PBB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

61622:LOC104668848
gene id: 61622:LOC104668848
uniprot id: A0A2K6QU79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:ELK3
gene id: 61622:ELK3
uniprot id: A0A2K6QJL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:LOC104668917
gene id: 61622:LOC104668917
uniprot id: A0A2K6R1M2
names: Similarity
messages: Belongs to the PRAME family.

61622:LOC104655977
gene id: 61622:LOC104655977
uniprot id: A0A2K6RH76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

61622:RIC3
gene id: 61622:RIC3
uniprot id: A0A2K6QMG7
names: Similarity
messages: Belongs to the ric-3 family.

61622:TCEAL1
gene id: 61622:TCEAL1
uniprot id: A0A2K6NN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family. TFA subfamily.
messages: Nucleus

61622:VEZT
gene id: 61622:VEZT
uniprot id: A0A2K6RHA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction

61622:SI
gene id: 61622:SI
uniprot id: A0A2K6RK08
names: Caution
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:FDXR
gene id: 61622:FDXR
uniprot id: A0A2K6R7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

61622:UBE2R2
gene id: 61622:UBE2R2
uniprot id: A0A2K6Q710
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:SMC1A
gene id: 61622:SMC1A
uniprot id: A0A2K6QI63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

61622:EPHA3
gene id: 61622:EPHA3
uniprot id: A0A2K6RAC4
names: Subcellular Location Annotation
messages: Membrane

61622:DCTN2
gene id: 61622:DCTN2
uniprot id: A0A2K6QJQ6
names: Function
names: Similarity
messages: Belongs to the dynactin subunit 2 family.
messages: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

61622:L3HYPDH
gene id: 61622:L3HYPDH
uniprot id: A0A2K6RQC8
names: Similarity
messages: Belongs to the proline racemase family.

61622:GNAI3
gene id: 61622:GNAI3
uniprot id: A0A2K6PMI8
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61622:CLDN10
gene id: 61622:CLDN10
uniprot id: A0A2K6PZD4
uniprot id: A0A2K6PZE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:PROKR1
gene id: 61622:PROKR1
uniprot id: A0A2K6QDB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:SULT2A1
gene id: 61622:SULT2A1
uniprot id: A0A2K6PVG7
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:ACAA1
gene id: 61622:ACAA1
uniprot id: A0A2K6P348
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

61622:PDE11A
gene id: 61622:PDE11A
uniprot id: A0A2K6NWU0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:ADAMTS14
gene id: 61622:ADAMTS14
uniprot id: A0A2K6QRF2
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:LEPR
gene id: 61622:LEPR
uniprot id: A0A2K6PUA7
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

61622:VENTX
gene id: 61622:VENTX
uniprot id: A0A2K6NVK5
names: Subcellular Location Annotation
messages: Nucleus

61622:PSAP
gene id: 61622:PSAP
uniprot id: A0A2K6PRY0
names: Function
names: Subcellular Location Annotation
messages: Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
messages: Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
messages: Secreted

61622:METTL3
gene id: 61622:METTL3
uniprot id: A0A2K6P2R6
names: Similarity
messages: Belongs to the MT-A70-like family.

61622:SHBG
gene id: 61622:SHBG
uniprot id: A0A2K6R222
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HIP1
gene id: 61622:HIP1
uniprot id: A0A2K6RF64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA2 family.
messages: Membrane

61622:ENPEP
gene id: 61622:ENPEP
uniprot id: A0A2K6QD18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homodimer; disulfide-linked.
messages: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

61622:ANAPC5
gene id: 61622:ANAPC5
uniprot id: A0A2K6PPS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

61622:RGS7BP
gene id: 61622:RGS7BP
uniprot id: A0A2K6NUN8
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

61622:GORAB
gene id: 61622:GORAB
uniprot id: A0A2K6QWA2
names: Similarity
messages: Belongs to the GORAB family.

61622:VAT1
gene id: 61622:VAT1
uniprot id: A0A2K6R4V9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

61622:MS4A1
gene id: 61622:MS4A1
uniprot id: A0A2K6REK5
names: Similarity
messages: Belongs to the MS4A family.

61622:VIL1
gene id: 61622:VIL1
uniprot id: A0A2K6R779
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the villin/gelsolin family.
messages: filopodium tip
messages: lamellipodium
messages: microvillus
messages: ruffle

61622:SEC22C
gene id: 61622:SEC22C
uniprot id: A0A2K6RDJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

61622:CDK2
gene id: 61622:CDK2
uniprot id: A0A2K6P9I2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:FOXF1
gene id: 61622:FOXF1
uniprot id: A0A2K6NPR9
names: Subcellular Location Annotation
messages: Nucleus

61622:HBQ1
gene id: 61622:HBQ1
uniprot id: A0A2K6NMM6
names: Similarity
messages: Belongs to the globin family.

61622:ANAPC15
gene id: 61622:ANAPC15
uniprot id: A0A2K6PJE6
names: Similarity
messages: Belongs to the APC15 family.

61622:NDC80
gene id: 61622:NDC80
uniprot id: A0A2K6QZ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

61622:MOGAT3
gene id: 61622:MOGAT3
uniprot id: A0A2K6NWI0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RNASE8
gene id: 61622:RNASE8
uniprot id: A0A2K6NQU9
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61622:CAMK2N2
gene id: 61622:CAMK2N2
uniprot id: A0A2K6R6Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

61622:KRT40
gene id: 61622:KRT40
uniprot id: A0A2K6R0W8
names: Similarity
messages: Belongs to the intermediate filament family.

61622:TUBD1
gene id: 61622:TUBD1
uniprot id: A0A2K6RXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

61622:MCM8
gene id: 61622:MCM8
uniprot id: A0A2K6RWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

61622:PAM
gene id: 61622:PAM
uniprot id: A0A2K6QJY0
uniprot id: A0A2K6QJZ8
uniprot id: A0A2K6QK04
uniprot id: A0A2K6QK17
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

61622:LOC104659507
gene id: 61622:LOC104659507
uniprot id: A0A2K6Q8D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:D2HGDH
gene id: 61622:D2HGDH
uniprot id: A0A2K6P7W2
names: Similarity
messages: Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

61622:TRMT112
gene id: 61622:TRMT112
uniprot id: A0A2K6RNK8
names: Similarity
messages: Belongs to the TRM112 family.

61622:KDM4A
gene id: 61622:KDM4A
uniprot id: A0A2K6NRZ5
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

61622:SCARB1
gene id: 61622:SCARB1
uniprot id: A0A2K6PV33
uniprot id: A0A2K6PV40
names: Similarity
messages: Belongs to the CD36 family.

61622:B4GALT2
gene id: 61622:B4GALT2
uniprot id: A0A2K6NJ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:LOC104678627
gene id: 61622:LOC104678627
uniprot id: A0A2K6NA16
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:SRRD
gene id: 61622:SRRD
uniprot id: A0A2K6PUS9
names: Similarity
messages: Belongs to the SRR1 family.

61622:CACYBP
gene id: 61622:CACYBP
uniprot id: A0A2K6PKP1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

61622:FAM221A
gene id: 61622:FAM221A
uniprot id: A0A2K6NG16
names: Similarity
messages: Belongs to the FAM221 family.

61622:TNFSF11
gene id: 61622:TNFSF11
uniprot id: A0A2K6NVT6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

61622:DBX2
gene id: 61622:DBX2
uniprot id: A0A2K6PNJ9
names: Subcellular Location Annotation
messages: Nucleus

61622:INTS9
gene id: 61622:INTS9
uniprot id: A0A2K6QYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

61622:DUXA
gene id: 61622:DUXA
uniprot id: A0A2K6R358
names: Subcellular Location Annotation
messages: Nucleus

61622:NEURL2
gene id: 61622:NEURL2
uniprot id: A0A2K6NQR2
names: Subcellular Location Annotation
messages: Cytoplasm

61622:FUNDC2
gene id: 61622:FUNDC2
uniprot id: A0A2K6RHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

61622:PBX4
gene id: 61622:PBX4
uniprot id: A0A2K6PNF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

61622:DBT
gene id: 61622:DBT
uniprot id: A0A2K6QHE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61622:LOC104672151
gene id: 61622:LOC104672151
uniprot id: A0A2K6Q3U5
uniprot id: A0A2K6Q3V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:SPIC
gene id: 61622:SPIC
uniprot id: A0A2K6RMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:CNFN
gene id: 61622:CNFN
uniprot id: A0A2K6PW70
names: Similarity
messages: Belongs to the cornifelin family.

61622:PFAS
gene id: 61622:PFAS
uniprot id: A0A2K6RPV4
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

61622:GPN3
gene id: 61622:GPN3
uniprot id: A0A2K6RF07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

61622:MZF1
gene id: 61622:MZF1
uniprot id: A0A2K6QTV1
names: Subcellular Location Annotation
messages: Nucleus

61622:RABGGTB
gene id: 61622:RABGGTB
uniprot id: A0A2K6RE21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

61622:FBXO25
gene id: 61622:FBXO25
uniprot id: A0A2K6NIL9
uniprot id: A0A2K6NIN7
names: Subcellular Location Annotation
messages: Nucleus

61622:ISM2
gene id: 61622:ISM2
uniprot id: A0A2K6Q467
names: Similarity
messages: Belongs to the isthmin family.

61622:LOC104679942
gene id: 61622:LOC104679942
uniprot id: A0A2K6P781
names: Similarity
messages: Belongs to the p23/wos2 family.

61622:APTX
gene id: 61622:APTX
uniprot id: A0A2K6Q2U0
names: Subcellular Location Annotation
messages: nucleolus
messages: nucleoplasm

61622:NCAPH2
gene id: 61622:NCAPH2
uniprot id: A0A2K6NMB1
names: Similarity
messages: Belongs to the CND2 H2 (condensin-2 subunit 2) family.

61622:ROMO1
gene id: 61622:ROMO1
uniprot id: A0A2K6QIV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

61622:SRRT
gene id: 61622:SRRT
uniprot id: A0A2K6P862
names: Similarity
messages: Belongs to the ARS2 family.

61622:RBFOX1
gene id: 61622:RBFOX1
uniprot id: A0A2K6RNH3
uniprot id: A0A2K6RNH6
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

61622:VPS37B
gene id: 61622:VPS37B
uniprot id: A0A2K6R6A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:SLC8A3
gene id: 61622:SLC8A3
uniprot id: A0A2K6NSH5
uniprot id: A0A2K6NSI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
messages: Cell membrane
messages: Membrane

61622:IMPDH2
gene id: 61622:IMPDH2
uniprot id: A0A2K6NA66
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

61622:CGA
gene id: 61622:CGA
uniprot id: A0A2K6PNV9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted

61622:GABRQ
gene id: 61622:GABRQ
uniprot id: A0A2K6N752
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:CASP10
gene id: 61622:CASP10
uniprot id: A0A2K6RRS2
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:PLK1
gene id: 61622:PLK1
uniprot id: A0A2K6QHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
messages: Midbody
messages: Nucleus
messages: centrosome

61622:PPCS
gene id: 61622:PPCS
uniprot id: A0A2K6NJB9
names: Similarity
messages: Belongs to the PPC synthetase family.

61622:STK17B
gene id: 61622:STK17B
uniprot id: A0A2K6QX26
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MAN1B1
gene id: 61622:MAN1B1
uniprot id: A0A2K6RP46
uniprot id: A0A2K6RP57
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:STXBP2
gene id: 61622:STXBP2
uniprot id: A0A2K6PF80
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61622:KCNA3
gene id: 61622:KCNA3
uniprot id: A0A2K6N7U7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:IMMP1L
gene id: 61622:IMMP1L
uniprot id: A0A2K6QZU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

61622:CLVS1
gene id: 61622:CLVS1
uniprot id: A0A2K6PKB4
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

61622:SNAP23
gene id: 61622:SNAP23
uniprot id: A0A2K6NY34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

61622:KCNH4
gene id: 61622:KCNH4
uniprot id: A0A2K6RG24
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

61622:MAN1A2
gene id: 61622:MAN1A2
uniprot id: A0A2K6N7Z3
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:ZSCAN12
gene id: 61622:ZSCAN12
uniprot id: A0A2K6RW34
names: Subcellular Location Annotation
messages: Nucleus

61622:TSN
gene id: 61622:TSN
uniprot id: A0A2K6P3U0
uniprot id: A0A2K6P3U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

61622:TMEM184A
gene id: 61622:TMEM184A
uniprot id: A0A2K6RG85
names: Subcellular Location Annotation
messages: Membrane

61622:ASB11
gene id: 61622:ASB11
uniprot id: A0A2K6RGG1
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:KIFC3
gene id: 61622:KIFC3
uniprot id: A0A2K6P9F3
uniprot id: A0A2K6P9L0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:EEF1B2
gene id: 61622:EEF1B2
uniprot id: A0A2K6R7G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

61622:CPLANE2
gene id: 61622:CPLANE2
uniprot id: A0A2K6RBJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.
messages: cilium basal body

61622:ATP11A
gene id: 61622:ATP11A
uniprot id: A0A2K6Q3R2
uniprot id: A0A2K6Q3T9
uniprot id: A0A2K6Q3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

61622:ABLIM2
gene id: 61622:ABLIM2
uniprot id: A0A2K6QN13
uniprot id: A0A2K6QN37
uniprot id: A0A2K6QN49
names: Subcellular Location Annotation
messages: Cytoplasm

61622:NEMF
gene id: 61622:NEMF
uniprot id: A0A2K6NPD1
uniprot id: A0A2K6NPD8
names: Similarity
messages: Belongs to the NEMF family.

61622:HCK
gene id: 61622:HCK
uniprot id: A0A2K6RJP6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:TMEM255B
gene id: 61622:TMEM255B
uniprot id: A0A2K6RW17
uniprot id: A0A2K6RW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

61622:LCN12
gene id: 61622:LCN12
uniprot id: A0A2K6QM48
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

61622:RELL1
gene id: 61622:RELL1
uniprot id: A0A2K6NDL3
names: Similarity
messages: Belongs to the RELT family.

61622:ARF4
gene id: 61622:ARF4
uniprot id: A0A2K6Q077
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

61622:C1H3orf70
gene id: 61622:C1H3orf70
uniprot id: A0A2K6RBK1
names: Similarity
messages: Belongs to the UPF0524 family.

61622:TSPAN2
gene id: 61622:TSPAN2
uniprot id: A0A2K6PNU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:LOC104663721
gene id: 61622:LOC104663721
uniprot id: A0A2K6P6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Cytoplasm

61622:EVA1C
gene id: 61622:EVA1C
uniprot id: A0A2K6Q838
uniprot id: A0A2K6Q841
names: Similarity
messages: Belongs to the EVA1 family.

61622:SLC16A6
gene id: 61622:SLC16A6
uniprot id: A0A2K6P337
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104655171
gene id: 61622:LOC104655171
uniprot id: A0A2K6R6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

61622:AHCYL1
gene id: 61622:AHCYL1
uniprot id: A0A2K6QBK6
uniprot id: A0A2K6QBL2
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

61622:PDGFC
gene id: 61622:PDGFC
uniprot id: A0A2K6QZW2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:NMNAT1
gene id: 61622:NMNAT1
uniprot id: A0A2K6R680
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

61622:LOC104654807
gene id: 61622:LOC104654807
uniprot id: A0A2K6RMY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:THYN1
gene id: 61622:THYN1
uniprot id: A0A2K6P0R5
names: Function
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

61622:MRPS16
gene id: 61622:MRPS16
uniprot id: A0A2K6R175
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

61622:ISCA1
gene id: 61622:ISCA1
uniprot id: A0A2K6Q879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

61622:IL17F
gene id: 61622:IL17F
uniprot id: A0A2K6NED4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-17 family.
messages: Secreted

61622:OXTR
gene id: 61622:OXTR
uniprot id: A0A2K6RB62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

61622:PLN
gene id: 61622:PLN
uniprot id: A0A2K6NPP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

61622:STN1
gene id: 61622:STN1
uniprot id: A0A2K6NGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STN1 family.
messages: Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.
messages: Component of the CST complex.
messages: Nucleus
messages: telomere

61622:CBX5
gene id: 61622:CBX5
uniprot id: A0A2K6QYW9
names: Subcellular Location Annotation
messages: Nucleus

61622:POLB
gene id: 61622:POLB
uniprot id: A0A2K6PAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

61622:EMC9
gene id: 61622:EMC9
uniprot id: A0A2K6Q1D2
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

61622:SF3B5
gene id: 61622:SF3B5
uniprot id: A0A2K6QCY0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

61622:SGK2
gene id: 61622:SGK2
uniprot id: A0A2K6PAB0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:NLRP2
gene id: 61622:NLRP2
uniprot id: A0A2K6NJX4
names: Similarity
messages: Belongs to the NLRP family.

61622:LOC104679976
gene id: 61622:LOC104679976
uniprot id: A0A2K6P786
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

61622:MPP1
gene id: 61622:MPP1
uniprot id: A0A2K6PNM8
names: Function
names: Subcellular Location Annotation
messages: Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.
messages: stereocilium

61622:LOC104672160
gene id: 61622:LOC104672160
uniprot id: A0A2K6QYX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

61622:PEMT
gene id: 61622:PEMT
uniprot id: A0A2K6NSW8
uniprot id: A0A2K6NSY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

61622:PADI6
gene id: 61622:PADI6
uniprot id: A0A2K6QU72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

61622:OST4
gene id: 61622:OST4
uniprot id: A0A2K6N8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ATP6V1B2
gene id: 61622:ATP6V1B2
uniprot id: A0A2K6RJ83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

61622:OSBPL1A
gene id: 61622:OSBPL1A
uniprot id: A0A2K6RUM9
uniprot id: A0A2K6RUN9
names: Similarity
messages: Belongs to the OSBP family.

61622:MRPL33
gene id: 61622:MRPL33
uniprot id: A0A2K6PXU0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

61622:CHRM4
gene id: 61622:CHRM4
uniprot id: A0A2K6NNT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

61622:NDUFA3
gene id: 61622:NDUFA3
uniprot id: A0A2K6RX36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

61622:CSN3
gene id: 61622:CSN3
uniprot id: A0A2K6NY78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Secreted

61622:SLC10A4
gene id: 61622:SLC10A4
uniprot id: A0A2K6N8F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

61622:BLMH
gene id: 61622:BLMH
uniprot id: A0A2K6PC62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm

61622:DGKG
gene id: 61622:DGKG
uniprot id: A0A2K6PTT0
uniprot id: A0A2K6PTU1
uniprot id: A0A2K6PTU3
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61622:ENO2
gene id: 61622:ENO2
uniprot id: A0A2K6PCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

61622:DAXX
gene id: 61622:DAXX
uniprot id: A0A2K6PMK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAXX family.
messages: Cytoplasm
messages: PML body
messages: centromere
messages: nucleolus
messages: nucleoplasm

61622:ACTRT3
gene id: 61622:ACTRT3
uniprot id: A0A2K6Q218
names: Similarity
messages: Belongs to the actin family.

61622:LOC104664607
gene id: 61622:LOC104664607
uniprot id: A0A2K6Q308
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:LOC104664279
gene id: 61622:LOC104664279
uniprot id: A0A2K6P927
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:LOC104679997
gene id: 61622:LOC104679997
uniprot id: A0A2K6P095
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

61622:WTAP
gene id: 61622:WTAP
uniprot id: A0A2K6NXG7
names: Similarity
messages: Belongs to the fl(2)d family.

61622:CANX
gene id: 61622:CANX
uniprot id: A0A2K6PWJ2
names: Similarity
messages: Belongs to the calreticulin family.

61622:NAA25
gene id: 61622:NAA25
uniprot id: A0A2K6PTT1
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

61622:LOC104666883
gene id: 61622:LOC104666883
uniprot id: A0A2K6P927
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CHD4
gene id: 61622:CHD4
uniprot id: A0A2K6RAM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

61622:NODAL
gene id: 61622:NODAL
uniprot id: A0A2K6QIN4
names: Similarity
messages: Belongs to the TGF-beta family.

61622:PPP1R14A
gene id: 61622:PPP1R14A
uniprot id: A0A2K6N6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP1 inhibitor family.
messages: Cytoplasm
messages: Inhibitor of PPP1CA.

61622:KCTD11
gene id: 61622:KCTD11
uniprot id: A0A2K6NBP8
names: Subcellular Location Annotation
messages: Cell membrane

61622:RSRP1
gene id: 61622:RSRP1
uniprot id: A0A2K6QGC3
names: Similarity
messages: Belongs to the RSRP family.

61622:AHSA1
gene id: 61622:AHSA1
uniprot id: A0A2K6QV38
names: Similarity
messages: Belongs to the AHA1 family.

61622:AKAP8L
gene id: 61622:AKAP8L
uniprot id: A0A2K6PGC3
names: Similarity
messages: Belongs to the AKAP95 family.

61622:CIAO2B
gene id: 61622:CIAO2B
uniprot id: A0A2K6RQ59
names: Similarity
messages: Belongs to the MIP18 family.

61622:CR1L
gene id: 61622:CR1L
uniprot id: A0A2K6NGB0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CEP170
gene id: 61622:CEP170
uniprot id: A0A2K6QKR5
names: Similarity
messages: Belongs to the CEP170 family.

61622:TPMT
gene id: 61622:TPMT
uniprot id: A0A2K6QYF3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Monomer.

61622:OOEP
gene id: 61622:OOEP
uniprot id: A0A2K6PL80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDC1 family.
messages: Cytoplasm
messages: Nucleus

61622:NDUFC1
gene id: 61622:NDUFC1
uniprot id: A0A2K6NPD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:ARID5B
gene id: 61622:ARID5B
uniprot id: A0A2K6QUI3
uniprot id: A0A2K6QUK9
names: Similarity
messages: Belongs to the ARID5B family.

61622:SLC35A1
gene id: 61622:SLC35A1
uniprot id: A0A2K6PZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

61622:LOC104654420
gene id: 61622:LOC104654420
uniprot id: A0A2K6RB19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

61622:FAM131A
gene id: 61622:FAM131A
uniprot id: A0A2K6NZD4
names: Similarity
messages: Belongs to the FAM131 family.

61622:LOC104663575
gene id: 61622:LOC104663575
uniprot id: A0A2K6NJG1
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TMEM230
gene id: 61622:TMEM230
uniprot id: A0A2K6NCS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

61622:TADA3
gene id: 61622:TADA3
uniprot id: A0A2K6RS72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

61622:NDUFB4
gene id: 61622:NDUFB4
uniprot id: A0A2K6RVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:SLC29A1
gene id: 61622:SLC29A1
uniprot id: A0A2K6NXJ2
uniprot id: A0A2K6NXJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

61622:EIF3L
gene id: 61622:EIF3L
uniprot id: A0A2K6RIA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

61622:DMRTA2
gene id: 61622:DMRTA2
uniprot id: A0A2K6NGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:SCGN
gene id: 61622:SCGN
uniprot id: A0A2K6Q8J2
names: Subcellular Location Annotation
messages: secretory vesicle membrane

61622:RANBP10
gene id: 61622:RANBP10
uniprot id: A0A2K6Q1M8
names: Similarity
messages: Belongs to the RANBP9/10 family.

61622:NUPR1
gene id: 61622:NUPR1
uniprot id: A0A2K6QSW0
names: Similarity
messages: Belongs to the NUPR family.

61622:PIK3R3
gene id: 61622:PIK3R3
uniprot id: A0A2K6QPZ6
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

61622:KEG34 p01
gene id: 61622:KEG34_p01
uniprot id: Q15GN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

61622:SLC30A4
gene id: 61622:SLC30A4
uniprot id: A0A2K6Q1G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:ATAD2B
gene id: 61622:ATAD2B
uniprot id: A0A2K6PEZ2
names: Similarity
messages: Belongs to the AAA ATPase family.

61622:TCTE3
gene id: 61622:TCTE3
uniprot id: A0A2K6NM75
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:LOC104671094
gene id: 61622:LOC104671094
uniprot id: A0A2K6PPY6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

61622:GPR179
gene id: 61622:GPR179
uniprot id: A0A2K6QC81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

61622:FAM118B
gene id: 61622:FAM118B
uniprot id: A0A2K6RTV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM118 family.
messages: Cajal body
messages: May play a role in Cajal bodies formation.

61622:PHYKPL
gene id: 61622:PHYKPL
uniprot id: A0A2K6PEH5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

61622:DLGAP1
gene id: 61622:DLGAP1
uniprot id: A0A2K6PPJ0
uniprot id: A0A2K6PPJ2
uniprot id: A0A2K6PPL0
uniprot id: A0A2K6PPL6
names: Similarity
messages: Belongs to the SAPAP family.

61622:SLC13A1
gene id: 61622:SLC13A1
uniprot id: A0A2K6Q287
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:ZW10
gene id: 61622:ZW10
uniprot id: A0A2K6PF89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZW10 family.
messages: kinetochore

61622:SNX17
gene id: 61622:SNX17
uniprot id: A0A2K6PAD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome
messages: Membrane

61622:ALDH3A2
gene id: 61622:ALDH3A2
uniprot id: A0A2K6QD73
uniprot id: A0A2K6QD74
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:TRIM6
gene id: 61622:TRIM6
uniprot id: A0A2K6N8U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

61622:ASB12
gene id: 61622:ASB12
uniprot id: A0A2K6P726
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:LHFPL1
gene id: 61622:LHFPL1
uniprot id: A0A2K6Q7E5
names: Subcellular Location Annotation
messages: Membrane

61622:EGFL7
gene id: 61622:EGFL7
uniprot id: A0A2K6RCX3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:WRNIP1
gene id: 61622:WRNIP1
uniprot id: A0A2K6P6X7
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

61622:SLC25A27
gene id: 61622:SLC25A27
uniprot id: A0A2K6QXN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:TSPAN33
gene id: 61622:TSPAN33
uniprot id: A0A2K6P9J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:OPRPN
gene id: 61622:OPRPN
uniprot id: A0A2K6PVW2
names: Subcellular Location Annotation
messages: Secreted

61622:HOXD4
gene id: 61622:HOXD4
uniprot id: A0A2K6NRK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:GNA14
gene id: 61622:GNA14
uniprot id: A0A2K6QD59
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

61622:MRPS9
gene id: 61622:MRPS9
uniprot id: A0A2K6RNJ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

61622:C5H15orf40
gene id: 61622:C5H15orf40
uniprot id: A0A2K6P585
names: Similarity
messages: Belongs to the UPF0235 family.

61622:KLHL15
gene id: 61622:KLHL15
uniprot id: A0A2K6P4D5
names: Subcellular Location Annotation
messages: Nucleus

61622:ACTN2
gene id: 61622:ACTN2
uniprot id: A0A2K6NUW3
names: Similarity
messages: Belongs to the alpha-actinin family.

61622:APOC3
gene id: 61622:APOC3
uniprot id: A0A2K6RCA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

61622:NTSR1
gene id: 61622:NTSR1
uniprot id: A0A2K6P0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:MYBL1
gene id: 61622:MYBL1
uniprot id: A0A2K6RJ70
uniprot id: A0A2K6RJ77
names: Subcellular Location Annotation
messages: Nucleus

61622:SERPINF1
gene id: 61622:SERPINF1
uniprot id: A0A2K6NG92
names: Similarity
messages: Belongs to the serpin family.

61622:GNA15
gene id: 61622:GNA15
uniprot id: A0A2K6Q3S7
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

61622:TDP2
gene id: 61622:TDP2
uniprot id: A0A2K6NAJ6
names: Subcellular Location Annotation
messages: PML body

61622:ACTL6A
gene id: 61622:ACTL6A
uniprot id: A0A2K6Q1R4
names: Similarity
messages: Belongs to the actin family.

61622:MICALL2
gene id: 61622:MICALL2
uniprot id: A0A2K6R9J7
names: Subcellular Location Annotation
messages: Membrane

61622:PSMD9
gene id: 61622:PSMD9
uniprot id: A0A2K6RAR5
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

61622:SLC13A2
gene id: 61622:SLC13A2
uniprot id: A0A2K6QCA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:TAF6L
gene id: 61622:TAF6L
uniprot id: A0A2K6N7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

61622:EXOG
gene id: 61622:EXOG
uniprot id: A0A2K6RTG7
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

61622:VTA1
gene id: 61622:VTA1
uniprot id: A0A2K6R102
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

61622:ATG2B
gene id: 61622:ATG2B
uniprot id: A0A2K6NPK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

61622:GNAL
gene id: 61622:GNAL
uniprot id: A0A2K6PPJ8
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

61622:ATP1B3
gene id: 61622:ATP1B3
uniprot id: A0A2K6P7K1
uniprot id: A0A2K6P7Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

61622:AFF1
gene id: 61622:AFF1
uniprot id: A0A2K6RXA0
uniprot id: A0A2K6RXC7
names: Similarity
messages: Belongs to the AF4 family.

61622:IGFBP2
gene id: 61622:IGFBP2
uniprot id: A0A2K6N8C6
names: Caution
names: Subcellular Location Annotation
names: Subunit
messages: Binds IGF2 more than IGF1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:TARDBP
gene id: 61622:TARDBP
uniprot id: A0A2K6QV39
names: Subcellular Location Annotation
messages: Nucleus

61622:ZFYVE9
gene id: 61622:ZFYVE9
uniprot id: A0A2K6Q209
uniprot id: A0A2K6Q210
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

61622:SLC7A8
gene id: 61622:SLC7A8
uniprot id: A0A2K6Q1Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

61622:NTRK3
gene id: 61622:NTRK3
uniprot id: A0A2K6RT13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

61622:CTNS
gene id: 61622:CTNS
uniprot id: A0A2K6QMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cystinosin family.
messages: Membrane

61622:NQO1
gene id: 61622:NQO1
uniprot id: A0A2K6RLR8
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

61622:TOR1B
gene id: 61622:TOR1B
uniprot id: A0A2K6NWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

61622:PLD3
gene id: 61622:PLD3
uniprot id: A0A2K6R3J4
names: Similarity
messages: Belongs to the phospholipase D family.

61622:ST6GALNAC2
gene id: 61622:ST6GALNAC2
uniprot id: A0A2K6Q7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:ZKSCAN2
gene id: 61622:ZKSCAN2
uniprot id: A0A2K6NCH3
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:IPO11
gene id: 61622:IPO11
uniprot id: A0A2K6QXU1
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PHPT1
gene id: 61622:PHPT1
uniprot id: A0A2K6NEM7
uniprot id: A0A2K6NEQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

61622:TRHDE
gene id: 61622:TRHDE
uniprot id: A0A2K6Q3R4
names: Similarity
messages: Belongs to the peptidase M1 family.

61622:RHOXF1
gene id: 61622:RHOXF1
uniprot id: A0A2K6Q196
names: Subcellular Location Annotation
messages: Nucleus

61622:ADAT2
gene id: 61622:ADAT2
uniprot id: A0A2K6QST3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
messages: Cytoplasm
messages: Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

61622:RPS25
gene id: 61622:RPS25
uniprot id: A0A2K6NXD7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

61622:NPPA
gene id: 61622:NPPA
uniprot id: A0A2K6NZ81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the natriuretic peptide family.
messages: Cell projection
messages: Homodimer; disulfide-linked antiparallel dimer.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal and vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips.
messages: May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips.
messages: Secreted

61622:TNFRSF9
gene id: 61622:TNFRSF9
uniprot id: A0A2K6R295
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MYC
gene id: 61622:MYC
uniprot id: A0A2K6PIE5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
messages: nucleolus
messages: nucleoplasm

61622:ATG7
gene id: 61622:ATG7
uniprot id: A0A2K6R1U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.
messages: Homodimer.
messages: Preautophagosomal structure

61622:NEDD9
gene id: 61622:NEDD9
uniprot id: A0A2K6QID3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61622:CLDN17
gene id: 61622:CLDN17
uniprot id: A0A2K6NQW3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:XKR8
gene id: 61622:XKR8
uniprot id: A0A2K6PUV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61622:POLR3K
gene id: 61622:POLR3K
uniprot id: A0A2K6QTU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

61622:PPP1R1B
gene id: 61622:PPP1R1B
uniprot id: A0A2K6PCI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein phosphatase inhibitor 1 family.
messages: Cytoplasm
messages: Inhibitor of protein-phosphatase 1.

61622:OSMR
gene id: 61622:OSMR
uniprot id: A0A2K6RPY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

61622:CRP
gene id: 61622:CRP
uniprot id: A0A2K6RS55
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:CD79B
gene id: 61622:CD79B
uniprot id: A0A2K6PPC8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:PDE7A
gene id: 61622:PDE7A
uniprot id: A0A2K6RAA6
uniprot id: A0A2K6RAB7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:LOC104682087
gene id: 61622:LOC104682087
uniprot id: A0A2K6QGW4
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:CCL8
gene id: 61622:CCL8
uniprot id: A0A2K6PBT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:LOC104673110
gene id: 61622:LOC104673110
uniprot id: A0A2K6N9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:PCMTD2
gene id: 61622:PCMTD2
uniprot id: A0A2K6R8F6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61622:PDHX
gene id: 61622:PDHX
uniprot id: A0A2K6RT06
uniprot id: A0A2K6RT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Mitochondrion matrix

61622:KCTD19
gene id: 61622:KCTD19
uniprot id: A0A2K6PMV8
names: Subcellular Location Annotation
messages: Cell membrane

61622:PLA2G2E
gene id: 61622:PLA2G2E
uniprot id: A0A2K6RVT4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:ALDH3B2
gene id: 61622:ALDH3B2
uniprot id: A0A2K6P8G5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:KLHL21
gene id: 61622:KLHL21
uniprot id: A0A2K6RHJ1
names: Subcellular Location Annotation
messages: spindle

61622:RAB14
gene id: 61622:RAB14
uniprot id: A0A2K6QJZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

61622:AGTRAP
gene id: 61622:AGTRAP
uniprot id: A0A2K6PSD9
names: Subcellular Location Annotation
messages: Membrane

61622:PALM2AKAP2
gene id: 61622:PALM2AKAP2
uniprot id: A0A2K6NEU0
names: Similarity
messages: Belongs to the paralemmin family.

61622:CEBPE
gene id: 61622:CEBPE
uniprot id: A0A2K6QUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

61622:TOLLIP
gene id: 61622:TOLLIP
uniprot id: A0A2K6R0T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

61622:ZFPL1
gene id: 61622:ZFPL1
uniprot id: A0A2K6ND94
uniprot id: A0A2K6NDA9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

61622:FOXA2
gene id: 61622:FOXA2
uniprot id: A0A2K6NP24
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104663672
gene id: 61622:LOC104663672
uniprot id: A0A2K6NMA4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:EPHB4
gene id: 61622:EPHB4
uniprot id: A0A2K6RMZ1
names: Subcellular Location Annotation
messages: Membrane

61622:NCSTN
gene id: 61622:NCSTN
uniprot id: A0A2K6PLK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

61622:LPAR6
gene id: 61622:LPAR6
uniprot id: A0A2K6NGZ5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:SLCO2B1
gene id: 61622:SLCO2B1
uniprot id: A0A2K6NZ15
uniprot id: A0A2K6NZ32
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:NR2C2
gene id: 61622:NR2C2
uniprot id: A0A2K6R5C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:CD63
gene id: 61622:CD63
uniprot id: A0A2K6RSS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Cell surface
messages: Endosome membrane
messages: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Melanosome
messages: Membrane
messages: extracellular exosome
messages: multivesicular body

61622:ACOT6
gene id: 61622:ACOT6
uniprot id: A0A2K6R5G4
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:APPL2
gene id: 61622:APPL2
uniprot id: A0A2K6NHH9
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Nucleus
messages: phagosome
messages: ruffle

61622:MBD4
gene id: 61622:MBD4
uniprot id: A0A2K6NYN3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with MLH1.
messages: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
messages: Nucleus

61622:FAM162B
gene id: 61622:FAM162B
uniprot id: A0A2K6N8Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

61622:TTC19
gene id: 61622:TTC19
uniprot id: A0A2K6QAP5
uniprot id: A0A2K6QAQ5
names: Similarity
messages: Belongs to the TTC19 family.

61622:EIF2AK3
gene id: 61622:EIF2AK3
uniprot id: A0A2K6QP20
uniprot id: A0A2K6QP45
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61622:TAF4B
gene id: 61622:TAF4B
uniprot id: A0A2K6P5A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Nucleus

61622:MAEL
gene id: 61622:MAEL
uniprot id: A0A2K6QRB9
uniprot id: A0A2K6QRC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

61622:FUT7
gene id: 61622:FUT7
uniprot id: A0A2K6QU35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane
messages: Membrane

61622:NDST3
gene id: 61622:NDST3
uniprot id: A0A2K6Q113
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

61622:SRPX2
gene id: 61622:SRPX2
uniprot id: A0A2K6QM54
names: Caution
names: Subcellular Location Annotation
messages: Cell surface
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Synapse

61622:MAT2A
gene id: 61622:MAT2A
uniprot id: A0A2K6QRB7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

61622:SNX21
gene id: 61622:SNX21
uniprot id: A0A2K6NVC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

61622:MRS2
gene id: 61622:MRS2
uniprot id: A0A2K6RP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

61622:KDSR
gene id: 61622:KDSR
uniprot id: A0A2K6RV29
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:NIFK
gene id: 61622:NIFK
uniprot id: A0A2K6QS39
names: Subcellular Location Annotation
messages: nucleolus

61622:SNX11
gene id: 61622:SNX11
uniprot id: A0A2K6P0P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

61622:EPHA5
gene id: 61622:EPHA5
uniprot id: A0A2K6PEK1
uniprot id: A0A2K6PEN3
names: Subcellular Location Annotation
messages: Membrane

61622:PRTFDC1
gene id: 61622:PRTFDC1
uniprot id: A0A2K6QBK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

61622:FAM219B
gene id: 61622:FAM219B
uniprot id: A0A2K6PBT5
names: Similarity
messages: Belongs to the FAM219 family.

61622:ASZ1
gene id: 61622:ASZ1
uniprot id: A0A2K6R665
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

61622:SUFU
gene id: 61622:SUFU
uniprot id: A0A2K6NDB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

61622:HDDC2
gene id: 61622:HDDC2
uniprot id: A0A2K6PRK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

61622:IGF1
gene id: 61622:IGF1
uniprot id: A0A2K6Q9L9
uniprot id: A0A2K6Q9M0
uniprot id: A0A2K6Q9N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

61622:CRELD1
gene id: 61622:CRELD1
uniprot id: A0A2K6NU36
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CKS2
gene id: 61622:CKS2
uniprot id: A0A2K6QUX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

61622:SLC15A2
gene id: 61622:SLC15A2
uniprot id: A0A2K6RDS8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

61622:ADRM1
gene id: 61622:ADRM1
uniprot id: A0A2K6NKA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

61622:MYOF
gene id: 61622:MYOF
uniprot id: A0A2K6P7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

61622:IL6
gene id: 61622:IL6
uniprot id: A0A2K6NAR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

61622:LDB2
gene id: 61622:LDB2
uniprot id: A0A2K6PBK1
uniprot id: A0A2K6PBS8
names: Similarity
messages: Belongs to the LDB family.

61622:CD70
gene id: 61622:CD70
uniprot id: A0A2K6QZG2
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:RIN1
gene id: 61622:RIN1
uniprot id: A0A2K6RPC9
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

61622:ANP32E
gene id: 61622:ANP32E
uniprot id: A0A2K6P4D9
uniprot id: A0A2K6P4F3
names: Similarity
messages: Belongs to the ANP32 family.

61622:FAM167B
gene id: 61622:FAM167B
uniprot id: A0A2K6PU96
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

61622:LOC104659421
gene id: 61622:LOC104659421
uniprot id: A0A2K6NKT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:LAPTM5
gene id: 61622:LAPTM5
uniprot id: A0A2K6N772
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

61622:C15H11orf88
gene id: 61622:C15H11orf88
uniprot id: A0A2K6QUP9
uniprot id: A0A2K6QUS1
names: Similarity
messages: Belongs to the HOATZ family.

61622:TMEM237
gene id: 61622:TMEM237
uniprot id: A0A2K6RIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM237 family.
messages: Component of the transition zone in primary cilia. Required for ciliogenesis.
messages: Membrane
messages: cilium

61622:CHST9
gene id: 61622:CHST9
uniprot id: A0A2K6Q3E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:TMEM255A
gene id: 61622:TMEM255A
uniprot id: A0A2K6RX59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

61622:BARHL1
gene id: 61622:BARHL1
uniprot id: A0A2K6P349
names: Subcellular Location Annotation
messages: Nucleus

61622:ENTPD7
gene id: 61622:ENTPD7
uniprot id: A0A2K6QIZ6
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:TMEM145
gene id: 61622:TMEM145
uniprot id: A0A2K6P4F7
names: Subcellular Location Annotation
messages: Membrane

61622:KCNJ1
gene id: 61622:KCNJ1
uniprot id: A0A2K6RES0
uniprot id: A0A2K6RES4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:FMO3
gene id: 61622:FMO3
uniprot id: A0A2K6N8Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Microsome membrane

61622:CYFIP2
gene id: 61622:CYFIP2
uniprot id: A0A2K6QQ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYFIP family.
messages: synaptosome

61622:TSTA3
gene id: 61622:TSTA3
uniprot id: A0A2K6Q4E1
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

61622:LOC104656984
gene id: 61622:LOC104656984
uniprot id: A0A2K6PAI0
names: Similarity
messages: Belongs to the cytochrome b5 family.

61622:ERMAP
gene id: 61622:ERMAP
uniprot id: A0A2K6RT43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

61622:STX17
gene id: 61622:STX17
uniprot id: A0A2K6P8H7
names: Similarity
messages: Belongs to the syntaxin family.

61622:EEF2
gene id: 61622:EEF2
uniprot id: A0A2K6NKG3
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

61622:CRAT
gene id: 61622:CRAT
uniprot id: A0A2K6NVZ4
uniprot id: A0A2K6NVZ5
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61622:NUDT17
gene id: 61622:NUDT17
uniprot id: A0A2K6R558
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

61622:A4GNT
gene id: 61622:A4GNT
uniprot id: A0A2K6QYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

61622:ASB5
gene id: 61622:ASB5
uniprot id: A0A2K6QXZ5
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:TP53RK
gene id: 61622:TP53RK
uniprot id: A0A2K6NC99
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

61622:MIS12
gene id: 61622:MIS12
uniprot id: A0A2K6NMH4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

61622:SLCO1B3
gene id: 61622:SLCO1B3
uniprot id: A0A2K6QNX2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:MASTL
gene id: 61622:MASTL
uniprot id: A0A2K6NZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Nucleus
messages: centrosome

61622:PRKCI
gene id: 61622:PRKCI
uniprot id: A0A2K6QNJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

61622:HPS5
gene id: 61622:HPS5
uniprot id: A0A2K6RW53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

61622:IER5
gene id: 61622:IER5
uniprot id: A0A2K6N8T4
names: Similarity
messages: Belongs to the IER family.

61622:BRINP3
gene id: 61622:BRINP3
uniprot id: A0A2K6NTK9
names: Similarity
messages: Belongs to the BRINP family.

61622:NINJ2
gene id: 61622:NINJ2
uniprot id: A0A2K6RVZ8
uniprot id: A0A2K6RW01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

61622:STX10
gene id: 61622:STX10
uniprot id: A0A2K6QZB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

61622:RPS15
gene id: 61622:RPS15
uniprot id: A0A2K6QL48
uniprot id: A0A2K6QL61
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

61622:KCNS1
gene id: 61622:KCNS1
uniprot id: A0A2K6RS78
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:C13H20orf27
gene id: 61622:C13H20orf27
uniprot id: A0A2K6R1L9
names: Similarity
messages: Belongs to the UPF0687 family.

61622:PLAGL2
gene id: 61622:PLAGL2
uniprot id: A0A2K6R7H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

61622:PREP
gene id: 61622:PREP
uniprot id: A0A2K6QZE8
names: Similarity
messages: Belongs to the peptidase S9A family.

61622:KEG34 p04
gene id: 61622:KEG34_p04
uniprot id: Q15GN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61622:OPA3
gene id: 61622:OPA3
uniprot id: A0A2K6PVU3
uniprot id: A0A2K6PVU6
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

61622:BCL9L
gene id: 61622:BCL9L
uniprot id: A0A2K6QXE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

61622:RPL37A
gene id: 61622:RPL37A
uniprot id: A0A2K6N7Q7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

61622:LOC104674031
gene id: 61622:LOC104674031
uniprot id: A0A2K6NRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CREB3L2
gene id: 61622:CREB3L2
uniprot id: A0A2K6RUJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. ATF subfamily.
messages: Binds DNA as a dimer.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

61622:NPR2
gene id: 61622:NPR2
uniprot id: A0A2K6Q6M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

61622:BPI
gene id: 61622:BPI
uniprot id: A0A2K6QLR6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Cytoplasmic granule membrane
messages: Membrane
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

61622:FRK
gene id: 61622:FRK
uniprot id: A0A2K6NE13
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:SLFN13
gene id: 61622:SLFN13
uniprot id: A0A2K6NJI0
names: Similarity
messages: Belongs to the Schlafen family. Subgroup III subfamily.

61622:LTV1
gene id: 61622:LTV1
uniprot id: A0A2K6RPK0
names: Similarity
messages: Belongs to the LTV1 family.

61622:OSBPL9
gene id: 61622:OSBPL9
uniprot id: A0A2K6RQT4
uniprot id: A0A2K6RQW6
uniprot id: A0A2K6RQX3
names: Similarity
messages: Belongs to the OSBP family.

61622:LOC104663440
gene id: 61622:LOC104663440
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CILP
gene id: 61622:CILP
uniprot id: A0A2K6QHX6
names: Subcellular Location Annotation
messages: extracellular matrix

61622:TSHZ3
gene id: 61622:TSHZ3
uniprot id: A0A2K6P4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

61622:LOC104663295
gene id: 61622:LOC104663295
uniprot id: A0A2K6PP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

61622:NKX2-1
gene id: 61622:NKX2-1
uniprot id: A0A2K6NIF7
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104657699
gene id: 61622:LOC104657699
uniprot id: A0A2K6NGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:DMPK
gene id: 61622:DMPK
uniprot id: A0A2K6QE74
uniprot id: A0A2K6QEA0
uniprot id: A0A2K6QEA6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

61622:PITX2
gene id: 61622:PITX2
uniprot id: A0A2K6R9X7
uniprot id: A0A2K6R9X8
uniprot id: A0A2K6RA13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

61622:GRIK4
gene id: 61622:GRIK4
uniprot id: A0A2K6Q7V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:LOC104673718
gene id: 61622:LOC104673718
uniprot id: A0A2K6NHD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:GPR50
gene id: 61622:GPR50
uniprot id: A0A0F6MYE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:NPEPPS
gene id: 61622:NPEPPS
uniprot id: A0A2K6QD95
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:AQP3
gene id: 61622:AQP3
uniprot id: A0A2K6NUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

61622:CCDC130
gene id: 61622:CCDC130
uniprot id: A0A2K6QTY7
names: Similarity
messages: Belongs to the CWC16 family.

61622:ALG12
gene id: 61622:ALG12
uniprot id: A0A2K6PUP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ACAD8
gene id: 61622:ACAD8
uniprot id: A0A2K6QEY2
uniprot id: A0A2K6QEZ2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:SLC13A5
gene id: 61622:SLC13A5
uniprot id: A0A2K6NE11
uniprot id: A0A2K6NE19
uniprot id: A0A2K6NE32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:CTSO
gene id: 61622:CTSO
uniprot id: A0A2K6PMD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:POMGNT2
gene id: 61622:POMGNT2
uniprot id: A0A2K6NE54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 61 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:GRIN3A
gene id: 61622:GRIN3A
uniprot id: A0A2K6PA97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

61622:PBX2
gene id: 61622:PBX2
uniprot id: A0A2K6QE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

61622:LOC104668174
gene id: 61622:LOC104668174
uniprot id: A0A2K6RQ54
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61622:GPR3
gene id: 61622:GPR3
uniprot id: A0A2K6NID0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SLC25A13
gene id: 61622:SLC25A13
uniprot id: A0A2K6Q4T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:COG4
gene id: 61622:COG4
uniprot id: A0A2K6QX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG4 family.
messages: Golgi apparatus membrane

61622:CASP2
gene id: 61622:CASP2
uniprot id: A0A2K6P664
uniprot id: A0A2K6P674
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:EVPL
gene id: 61622:EVPL
uniprot id: A0A2K6RW16
names: Subcellular Location Annotation
messages: cytoskeleton

61622:WEE2
gene id: 61622:WEE2
uniprot id: A0A2K6NGM6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Nucleus

61622:PDE2A
gene id: 61622:PDE2A
uniprot id: A0A2K6R893
uniprot id: A0A2K6R8D2
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:ATP6V1F
gene id: 61622:ATP6V1F
uniprot id: A0A2K6R4B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:PRPF3
gene id: 61622:PRPF3
uniprot id: A0A2K6NT02
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

61622:CDKN1B
gene id: 61622:CDKN1B
uniprot id: A0A2K6QDA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

61622:SUOX
gene id: 61622:SUOX
uniprot id: A0A2K6RLJ3
names: Function
names: Subunit
messages: Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
messages: Homodimer.

61622:DDR2
gene id: 61622:DDR2
uniprot id: A0A2K6QQ58
names: Subcellular Location Annotation
messages: Membrane

61622:CPSF7
gene id: 61622:CPSF7
uniprot id: A0A2K6RSL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

61622:LOC104655384
gene id: 61622:LOC104655384
uniprot id: A0A2K6RLV0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:DGKA
gene id: 61622:DGKA
uniprot id: A0A2K6NNS7
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

61622:ELF2
gene id: 61622:ELF2
uniprot id: A0A2K6PC08
uniprot id: A0A2K6PC56
uniprot id: A0A2K6PC61
uniprot id: A0A2K6PCA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:PRKD2
gene id: 61622:PRKD2
uniprot id: A0A2K6Q042
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

61622:DRC7
gene id: 61622:DRC7
uniprot id: A0A2K6RTC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC7 family.
messages: cilium axoneme
messages: flagellum
messages: flagellum axoneme

61622:SAMM50
gene id: 61622:SAMM50
uniprot id: A0A2K6R1J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAM50/omp85 family.
messages: Mitochondrion outer membrane

61622:SLC22A4
gene id: 61622:SLC22A4
uniprot id: A0A2K6PE03
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

61622:LOC104667500
gene id: 61622:LOC104667500
uniprot id: A0A2K6NCL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:FAM189B
gene id: 61622:FAM189B
uniprot id: A0A2K6PQK2
uniprot id: A0A2K6PQK5
names: Similarity
messages: Belongs to the ENTREP family.

61622:TTYH3
gene id: 61622:TTYH3
uniprot id: A0A2K6RS96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

61622:ACADVL
gene id: 61622:ACADVL
uniprot id: A0A2K6QIH4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:OAS2
gene id: 61622:OAS2
uniprot id: A0A2K6R262
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-5A synthase family.
messages: Cytoplasm

61622:OLFML1
gene id: 61622:OLFML1
uniprot id: A0A2K6P7W4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CCDC58
gene id: 61622:CCDC58
uniprot id: A0A2K6RVX7
names: Similarity
messages: Belongs to the MIX23 family.

61622:MEOX2
gene id: 61622:MEOX2
uniprot id: A0A2K6Q3P4
names: Subcellular Location Annotation
messages: Nucleus

61622:TRPM2
gene id: 61622:TRPM2
uniprot id: A0A2K6PNY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
messages: Cell membrane
messages: Membrane

61622:PXMP4
gene id: 61622:PXMP4
uniprot id: A0A2K6PT96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Interacts with PEX19.
messages: Peroxisome membrane

61622:ZSCAN16
gene id: 61622:ZSCAN16
uniprot id: A0A2K6RC88
names: Subcellular Location Annotation
messages: Nucleus

61622:WIF1
gene id: 61622:WIF1
uniprot id: A0A2K6PJR9
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PF4
gene id: 61622:PF4
uniprot id: A0A2K6PHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:SLITRK4
gene id: 61622:SLITRK4
uniprot id: A0A2K6QB62
names: Similarity
messages: Belongs to the SLITRK family.

61622:MTMR10
gene id: 61622:MTMR10
uniprot id: A0A2K6RGK0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61622:LOC104673778
gene id: 61622:LOC104673778
uniprot id: A0A2K6NRC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:RFTN2
gene id: 61622:RFTN2
uniprot id: A0A2K6QV78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

61622:UCHL1
gene id: 61622:UCHL1
uniprot id: A0A2K6Q068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TMEM43
gene id: 61622:TMEM43
uniprot id: A0A2K6NTR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

61622:HNRNPA2B1
gene id: 61622:HNRNPA2B1
uniprot id: A0A2K6NKX6
uniprot id: A0A2K6NKY2
names: Subcellular Location Annotation
messages: Cytoplasmic granule
messages: extracellular exosome

61622:KCNJ4
gene id: 61622:KCNJ4
uniprot id: A0A2K6NCQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

61622:LGSN
gene id: 61622:LGSN
uniprot id: A0A2K6RJQ4
names: Similarity
messages: Belongs to the glutamine synthetase family.

61622:UIMC1
gene id: 61622:UIMC1
uniprot id: A0A2K6PCC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP80 family.
messages: Nucleus

61622:OTOP3
gene id: 61622:OTOP3
uniprot id: A0A2K6PQX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

61622:STRIP1
gene id: 61622:STRIP1
uniprot id: A0A2K6PMD2
names: Similarity
messages: Belongs to the STRIP family.

61622:CHN2
gene id: 61622:CHN2
uniprot id: A0A2K6QWY9
names: Function
messages: GTPase-activating protein for p21-rac.

61622:ETFA
gene id: 61622:ETFA
uniprot id: A0A2K6Q7Q3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

61622:LOC104682234
gene id: 61622:LOC104682234
uniprot id: A0A2K6QHL3
names: Similarity
messages: Belongs to the serpin family.

61622:CKS1B
gene id: 61622:CKS1B
uniprot id: A0A2K6NPU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

61622:ADIPOR1
gene id: 61622:ADIPOR1
uniprot id: A0A2K6PJM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:GNB5
gene id: 61622:GNB5
uniprot id: A0A2K6QRR3
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

61622:DVL3
gene id: 61622:DVL3
uniprot id: A0A2K6PVY9
names: Similarity
messages: Belongs to the DSH family.

61622:IGFBP6
gene id: 61622:IGFBP6
uniprot id: A0A2K6NW82
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:PGD
gene id: 61622:PGD
uniprot id: A0A2K6NJH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

61622:TAGLN
gene id: 61622:TAGLN
uniprot id: A0A2K6N7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calponin family.
messages: Cytoplasm

61622:FAM20A
gene id: 61622:FAM20A
uniprot id: A0A2K6NPK9
names: Similarity
messages: Belongs to the FAM20 family.

61622:DTNB
gene id: 61622:DTNB
uniprot id: A0A2K6R7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

61622:REEP6
gene id: 61622:REEP6
uniprot id: A0A2K6PLI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

61622:LOC104673976
gene id: 61622:LOC104673976
uniprot id: A0A2K6QEZ5
names: Function
names: Similarity
names: Subunit
messages: Component of the 40S subunit of the ribosome.
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

61622:PLSCR5
gene id: 61622:PLSCR5
uniprot id: A0A2K6RH65
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:TYSND1
gene id: 61622:TYSND1
uniprot id: A0A2K6N999
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1B family.
messages: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.
messages: Peroxisome
messages: The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.

61622:ADAM9
gene id: 61622:ADAM9
uniprot id: A0A2K6QVA2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ISCU
gene id: 61622:ISCU
uniprot id: A0A2K6QUI6
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

61622:ARL6
gene id: 61622:ARL6
uniprot id: A0A2K6R4F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

61622:ADHFE1
gene id: 61622:ADHFE1
uniprot id: A0A2K6R4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

61622:POP4
gene id: 61622:POP4
uniprot id: A0A2K6NXF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

61622:DAZAP2
gene id: 61622:DAZAP2
uniprot id: A0A2K6QB32
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus speckle
messages: nuclear body

61622:USP7
gene id: 61622:USP7
uniprot id: A0A2K6RLD9
names: Similarity
messages: Belongs to the peptidase C19 family.

61622:C7HXorf56
gene id: 61622:C7HXorf56
uniprot id: A0A2K6PG11
names: Similarity
messages: Belongs to the STEEP1 family.

61622:MMP1
gene id: 61622:MMP1
uniprot id: A0A2K6P8D9
names: Similarity
messages: Belongs to the peptidase M10A family.

61622:RC3H2
gene id: 61622:RC3H2
uniprot id: A0A2K6RJI4
names: Subcellular Location Annotation
messages: P-body

61622:LOC104676091
gene id: 61622:LOC104676091
uniprot id: A0A2K6QAL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:P4HA2
gene id: 61622:P4HA2
uniprot id: A0A2K6R3W4
uniprot id: A0A2K6R3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61622:GALNT17
gene id: 61622:GALNT17
uniprot id: A0A2K6P199
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:SZRD1
gene id: 61622:SZRD1
uniprot id: A0A2K6NIN2
uniprot id: A0A2K6PHH4
names: Similarity
messages: Belongs to the SZRD1 family.

61622:TM7SF2
gene id: 61622:TM7SF2
uniprot id: A0A2K6QL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

61622:CLDN19
gene id: 61622:CLDN19
uniprot id: A0A2K6R4K2
uniprot id: A0A2K6R4L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:ADGRG4
gene id: 61622:ADGRG4
uniprot id: A0A2K6NZ26
uniprot id: A0A2K6NZ36
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GRHL2
gene id: 61622:GRHL2
uniprot id: A0A2K6NCG8
names: Subcellular Location Annotation
messages: Nucleus

61622:LAMTOR5
gene id: 61622:LAMTOR5
uniprot id: A0A2K6RP35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

61622:SLC25A22
gene id: 61622:SLC25A22
uniprot id: A0A2K6RUR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:CZIB
gene id: 61622:CZIB
uniprot id: A0A2K6Q1F6
names: Similarity
messages: Belongs to the UPF0587 family.

61622:BAMBI
gene id: 61622:BAMBI
uniprot id: A0A2K6RW07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

61622:A3GALT2
gene id: 61622:A3GALT2
uniprot id: A0A2K6Q2P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Membrane

61622:MTMR7
gene id: 61622:MTMR7
uniprot id: A0A2K6NG86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

61622:DUS4L
gene id: 61622:DUS4L
uniprot id: A0A2K6N771
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

61622:TMEM87A
gene id: 61622:TMEM87A
uniprot id: A0A2K6QLD8
uniprot id: A0A2K6QLE0
names: Subcellular Location Annotation
messages: Membrane

61622:ABCC6
gene id: 61622:ABCC6
uniprot id: A0A2K6Q7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:RNF168
gene id: 61622:RNF168
uniprot id: A0A2K6RJU2
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Belongs to the RNF168 family.
messages: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
messages: Monomer. Interacts with UBE2N/UBC13.
messages: Nucleus
messages: Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
messages: The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).
messages: Ubiquitinated.

61622:TMEM229B
gene id: 61622:TMEM229B
uniprot id: A0A2K6NML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

61622:NPPB
gene id: 61622:NPPB
uniprot id: A0A2K6PKP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

61622:SLC46A3
gene id: 61622:SLC46A3
uniprot id: A0A2K6NGE2
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104668287
gene id: 61622:LOC104668287
uniprot id: A0A2K6QZH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

61622:TDO2
gene id: 61622:TDO2
uniprot id: A0A2K6NTD2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:BMP1
gene id: 61622:BMP1
uniprot id: A0A2K6QKE0
uniprot id: A0A2K6QKE4
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104658472
gene id: 61622:LOC104658472
uniprot id: A0A2K6N7R1
names: Subunit
messages: Interacts with hair keratins.

61622:LOC104670642
gene id: 61622:LOC104670642
uniprot id: A0A2K6R1C5
names: Similarity
messages: Belongs to the intermediate filament family.

61622:GCFC2
gene id: 61622:GCFC2
uniprot id: A0A2K6RBG2
names: Similarity
messages: Belongs to the GCF family.

61622:CHRNA9
gene id: 61622:CHRNA9
uniprot id: A0A2K6PEJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:GALNT15
gene id: 61622:GALNT15
uniprot id: A0A2K6QI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:F2RL2
gene id: 61622:F2RL2
uniprot id: A0A2K6QJ56
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:DEFB107A
gene id: 61622:DEFB107A
uniprot id: A0A2K6Q907
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:P2RY4
gene id: 61622:P2RY4
uniprot id: A0A2K6NAY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:BCDIN3D
gene id: 61622:BCDIN3D
uniprot id: A0A2K6NPQ3
names: Similarity
messages: Belongs to the methyltransferase superfamily.

61622:FAM187A
gene id: 61622:FAM187A
uniprot id: A0A2K6NIS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM187 family.
messages: Membrane

61622:POU6F2
gene id: 61622:POU6F2
uniprot id: A0A2K6Q213
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

61622:SLC35C1
gene id: 61622:SLC35C1
uniprot id: A0A2K6N7Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPT transporter family. SLC35C subfamily.
messages: Membrane

61622:PIK3IP1
gene id: 61622:PIK3IP1
uniprot id: A0A2K6QHK4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:APLP1
gene id: 61622:APLP1
uniprot id: A0A2K6R7N5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ACTG2
gene id: 61622:ACTG2
uniprot id: A0A2K6RD88
names: Similarity
messages: Belongs to the actin family.

61622:SYT2
gene id: 61622:SYT2
uniprot id: A0A2K6QNG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

61622:TSPAN5
gene id: 61622:TSPAN5
uniprot id: A0A2K6NF37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:CLP1
gene id: 61622:CLP1
uniprot id: A0A2K6QQQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.
messages: Nucleus
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.

61622:PLCG2
gene id: 61622:PLCG2
uniprot id: A0A2K6RT65
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

61622:ACOX3
gene id: 61622:ACOX3
uniprot id: A0A2K6R320
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61622:CDK1
gene id: 61622:CDK1
uniprot id: A0A2K6RH32
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:DMRT3
gene id: 61622:DMRT3
uniprot id: A0A2K6PQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:FAM216B
gene id: 61622:FAM216B
uniprot id: A0A2K6N9Q8
names: Similarity
messages: Belongs to the FAM216 family.

61622:TRNT1
gene id: 61622:TRNT1
uniprot id: A0A2K6QBT2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

61622:MMACHC
gene id: 61622:MMACHC
uniprot id: A0A2K6RJE5
names: Similarity
messages: Belongs to the MMACHC family.

61622:PROZ
gene id: 61622:PROZ
uniprot id: A0A2K6QUT7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104662597
gene id: 61622:LOC104662597
uniprot id: A0A2K6NS74
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:PEX7
gene id: 61622:PEX7
uniprot id: A0A2K6QBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Cytoplasm

61622:VPS37A
gene id: 61622:VPS37A
uniprot id: A0A2K6RRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:PSMF1
gene id: 61622:PSMF1
uniprot id: A0A2K6QM85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

61622:CPXM2
gene id: 61622:CPXM2
uniprot id: A0A2K6PZ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

61622:FCN1
gene id: 61622:FCN1
uniprot id: A0A2K6QMA6
names: Similarity
messages: Belongs to the ficolin lectin family.

61622:DNASE2
gene id: 61622:DNASE2
uniprot id: A0A2K6P3L0
names: Similarity
messages: Belongs to the DNase II family.

61622:TRPC7
gene id: 61622:TRPC7
uniprot id: A0A2K6PGB1
uniprot id: A0A2K6PGC0
uniprot id: A0A2K6PGJ2
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104676512
gene id: 61622:LOC104676512
uniprot id: A0A2K6NQ88
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:LTA4H
gene id: 61622:LTA4H
uniprot id: A0A2K6QQB0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

61622:CLTCL1
gene id: 61622:CLTCL1
uniprot id: A0A2K6NL24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

61622:APRT
gene id: 61622:APRT
uniprot id: A0A2K6PFQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

61622:GHITM
gene id: 61622:GHITM
uniprot id: A0A2K6NKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

61622:PBX3
gene id: 61622:PBX3
uniprot id: A0A2K6RXS2
uniprot id: A0A2K6RXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

61622:LOC104676969
gene id: 61622:LOC104676969
uniprot id: A0A2K6Q4K7
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

61622:EEF1AKMT2
gene id: 61622:EEF1AKMT2
uniprot id: A0A2K6RQ62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

61622:CACNA1G
gene id: 61622:CACNA1G
uniprot id: A0A2K6RGR7
uniprot id: A0A2K6RGR9
uniprot id: A0A2K6RGS2
uniprot id: A0A2K6RGS5
uniprot id: A0A2K6RGT3
uniprot id: A0A2K6RGV2
uniprot id: A0A2K6RGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

61622:USP15
gene id: 61622:USP15
uniprot id: A0A2K6QEW0
uniprot id: A0A2K6QEW9
uniprot id: A0A2K6QEX4
uniprot id: A0A2K6QEY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

61622:CD320
gene id: 61622:CD320
uniprot id: A0A2K6QJ19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SASS6
gene id: 61622:SASS6
uniprot id: A0A2K6PXH2
names: Subcellular Location Annotation
messages: centrosome

61622:TRPM3
gene id: 61622:TRPM3
uniprot id: A0A2K6NK24
uniprot id: A0A2K6NK45
uniprot id: A0A2K6NK46
uniprot id: A0A2K6NK47
uniprot id: A0A2K6NK68
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104671819
gene id: 61622:LOC104671819
uniprot id: A0A2K6NVV1
names: Similarity
messages: Belongs to the intermediate filament family.

61622:MED11
gene id: 61622:MED11
uniprot id: A0A2K6RWJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:RSL24D1
gene id: 61622:RSL24D1
uniprot id: A0A2K6R6X5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

61622:PIK3CA
gene id: 61622:PIK3CA
uniprot id: A0A2K6P5T5
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

61622:TSR1
gene id: 61622:TSR1
uniprot id: A0A2K6P6A1
names: Subcellular Location Annotation
messages: nucleolus

61622:TAF15
gene id: 61622:TAF15
uniprot id: A0A2K6P0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

61622:HEXIM1
gene id: 61622:HEXIM1
uniprot id: A0A2K6NG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

61622:ST18
gene id: 61622:ST18
uniprot id: A0A2K6NX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYT1 family.
messages: Nucleus

61622:HOXD8
gene id: 61622:HOXD8
uniprot id: A0A2K6NPE3
names: Subcellular Location Annotation
messages: Nucleus

61622:SULT2B1
gene id: 61622:SULT2B1
uniprot id: A0A2K6R469
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:PRAMEF12
gene id: 61622:PRAMEF12
uniprot id: A0A2K6N9W6
names: Similarity
messages: Belongs to the PRAME family.

61622:ADD3
gene id: 61622:ADD3
uniprot id: A0A2K6R644
uniprot id: A0A2K6R654
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

61622:SEMA6D
gene id: 61622:SEMA6D
uniprot id: A0A2K6NYN9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:MMP15
gene id: 61622:MMP15
uniprot id: A0A2K6PBH6
names: Similarity
messages: Belongs to the peptidase M10A family.

61622:CAMSAP2
gene id: 61622:CAMSAP2
uniprot id: A0A2K6Q2L1
names: Domain
names: Similarity
messages: Belongs to the CAMSAP1 family.
messages: The CKK domain binds microtubules.

61622:TMC6
gene id: 61622:TMC6
uniprot id: A0A2K6P2I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:RASGRP1
gene id: 61622:RASGRP1
uniprot id: A0A2K6RUI9
names: Similarity
messages: Belongs to the RASGRP family.

61622:NDNF
gene id: 61622:NDNF
uniprot id: A0A2K6PQ18
names: Subcellular Location Annotation
messages: Secreted

61622:NES
gene id: 61622:NES
uniprot id: A0A2K6PS34
names: Similarity
messages: Belongs to the intermediate filament family.

61622:CYGB
gene id: 61622:CYGB
uniprot id: A0A2K6QLH2
names: Similarity
messages: Belongs to the globin family.

61622:ADGRF5
gene id: 61622:ADGRF5
uniprot id: A0A2K6RDM7
uniprot id: A0A2K6RDP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

61622:RHPN1
gene id: 61622:RHPN1
uniprot id: A0A2K6Q4J4
names: Similarity
messages: Belongs to the RHPN family.

61622:RPL23A
gene id: 61622:RPL23A
uniprot id: A0A2K6PBJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

61622:APEH
gene id: 61622:APEH
uniprot id: A0A2K6NAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S9C family.
messages: Cytoplasm
messages: Homotetramer.
messages: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

61622:JAKMIP2
gene id: 61622:JAKMIP2
uniprot id: A0A2K6PE35
uniprot id: A0A2K6PE46
uniprot id: A0A2K6PE89
names: Similarity
messages: Belongs to the JAKMIP family.

61622:SLC9A3R1
gene id: 61622:SLC9A3R1
uniprot id: A0A2K6PSC0
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
messages: filopodium
messages: microvillus
messages: ruffle

61622:SERPINB6
gene id: 61622:SERPINB6
uniprot id: A0A2K6RBT5
names: Similarity
messages: Belongs to the serpin family.

61622:LOC104676875
gene id: 61622:LOC104676875
uniprot id: A0A2K6NM61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: Interacts with RPS19BP1.
messages: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

61622:MATN3
gene id: 61622:MATN3
uniprot id: A0A2K6PQV0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:KRT71
gene id: 61622:KRT71
uniprot id: A0A2K6Q6Z9
names: Similarity
messages: Belongs to the intermediate filament family.

61622:INPP5A
gene id: 61622:INPP5A
uniprot id: A0A2K6NV42
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.

61622:ANKS1B
gene id: 61622:ANKS1B
uniprot id: A0A2K6RE44
uniprot id: A0A2K6RE61
uniprot id: A0A2K6REB7
names: Subcellular Location Annotation
messages: Cytoplasm

61622:BLCAP
gene id: 61622:BLCAP
uniprot id: A0A2K6NJV2
names: Function
names: Similarity
messages: Belongs to the BLCAP family.
messages: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.

61622:SLC25A47
gene id: 61622:SLC25A47
uniprot id: A0A2K6PYP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:FYN
gene id: 61622:FYN
uniprot id: A0A2K6PQK4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:LOC104667407
gene id: 61622:LOC104667407
uniprot id: A0A2K6NF94
uniprot id: A0A2K6NFA2
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

61622:WNT8B
gene id: 61622:WNT8B
uniprot id: A0A2K6PYK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:SNW1
gene id: 61622:SNW1
uniprot id: A0A2K6PU52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

61622:APCS
gene id: 61622:APCS
uniprot id: A0A2K6QGM2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

61622:MAPK6
gene id: 61622:MAPK6
uniprot id: A0A2K6RH96
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

61622:MGST1
gene id: 61622:MGST1
uniprot id: A0A2K6QHG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

61622:STX6
gene id: 61622:STX6
uniprot id: A0A2K6R2E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Golgi apparatus membrane

61622:SPAG9
gene id: 61622:SPAG9
uniprot id: A0A2K6QGN3
uniprot id: A0A2K6QGN7
uniprot id: A0A2K6QGP9
names: Similarity
messages: Belongs to the JIP scaffold family.

61622:PLPPR4
gene id: 61622:PLPPR4
uniprot id: A0A2K6PQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

61622:FAM98C
gene id: 61622:FAM98C
uniprot id: A0A2K6NIU7
names: Similarity
messages: Belongs to the FAM98 family.

61622:RBPJL
gene id: 61622:RBPJL
uniprot id: A0A2K6PRB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

61622:ZMPSTE24
gene id: 61622:ZMPSTE24
uniprot id: A0A2K6NZZ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

61622:KIF6
gene id: 61622:KIF6
uniprot id: A0A2K6Q603
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:PIGU
gene id: 61622:PIGU
uniprot id: A0A2K6NZT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:INSRR
gene id: 61622:INSRR
uniprot id: A0A2K6QYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

61622:MANBA
gene id: 61622:MANBA
uniprot id: A0A2K6PHY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Lysosome
messages: Monomer.

61622:CDKN1A
gene id: 61622:CDKN1A
uniprot id: A0A2K6QEX5
names: Similarity
messages: Belongs to the CDI family.

61622:IRX5
gene id: 61622:IRX5
uniprot id: A0A2K6QL74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

61622:PCNX3
gene id: 61622:PCNX3
uniprot id: A0A2K6PDW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

61622:DAP3
gene id: 61622:DAP3
uniprot id: A0A2K6R3B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

61622:AKIRIN2
gene id: 61622:AKIRIN2
uniprot id: A0A2K6R6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

61622:TCEA1
gene id: 61622:TCEA1
uniprot id: A0A2K6N7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

61622:SULF2
gene id: 61622:SULF2
uniprot id: A0A2K6RSU7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cell surface
messages: Endoplasmic reticulum
messages: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
messages: Golgi stack
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:BRIX1
gene id: 61622:BRIX1
uniprot id: A0A2K6PBT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRX1 family.
messages: Required for biogenesis of the 60S ribosomal subunit.
messages: nucleolus

61622:CORO1A
gene id: 61622:CORO1A
uniprot id: A0A2K6R7R2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat coronin family.
messages: Binds actin.
messages: Membrane
messages: cell cortex
messages: cytoskeleton
messages: phagosome membrane

61622:SLC66A2
gene id: 61622:SLC66A2
uniprot id: A0A2K6PQB2
uniprot id: A0A2K6PQB8
uniprot id: A0A2K6PQC0
names: Subcellular Location Annotation
messages: Membrane

61622:GIMAP2
gene id: 61622:GIMAP2
uniprot id: A0A2K6QAI8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61622:PLAC1
gene id: 61622:PLAC1
uniprot id: A0A2K6NAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLAC1 family.
messages: Secreted

61622:LPAR1
gene id: 61622:LPAR1
uniprot id: A0A2K6PSN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

61622:LOC104661665
gene id: 61622:LOC104661665
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CDC5L
gene id: 61622:CDC5L
uniprot id: A0A2K6NZ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEF1 family.
messages: Nucleus

61622:SS18
gene id: 61622:SS18
uniprot id: A0A2K6REQ1
uniprot id: A0A2K6REU3
names: Similarity
messages: Belongs to the SS18 family.

61622:OSBPL10
gene id: 61622:OSBPL10
uniprot id: A0A2K6NT23
names: Similarity
messages: Belongs to the OSBP family.

61622:GART
gene id: 61622:GART
uniprot id: A0A2K6PGJ5
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

61622:PLCZ1
gene id: 61622:PLCZ1
uniprot id: A0A2K6NUJ9
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
messages: perinuclear region

61622:TRIP10
gene id: 61622:TRIP10
uniprot id: A0A2K6QFL5
names: Subcellular Location Annotation
messages: Membrane
messages: cell cortex

61622:ATP2C2
gene id: 61622:ATP2C2
uniprot id: A0A2K6P0T1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:P2RY13
gene id: 61622:P2RY13
uniprot id: A0A2K6RBN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:DSC2
gene id: 61622:DSC2
uniprot id: A0A2K6NMP8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:LOC104657997
gene id: 61622:LOC104657997
uniprot id: A0A2K6RES3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

61622:NUP58
gene id: 61622:NUP58
uniprot id: A0A2K6NIQ1
names: Subcellular Location Annotation
messages: nuclear pore complex

61622:TMEM178A
gene id: 61622:TMEM178A
uniprot id: A0A2K6RE99
names: Similarity
messages: Belongs to the TMEM178 family.

61622:SIX1
gene id: 61622:SIX1
uniprot id: A0A2K6PZA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Cytoplasm
messages: Nucleus

61622:PRPSAP2
gene id: 61622:PRPSAP2
uniprot id: A0A2K6NKN9
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

61622:NSFL1C
gene id: 61622:NSFL1C
uniprot id: A0A2K6QNU7
uniprot id: A0A2K6QNZ1
names: Subcellular Location Annotation
names: Subunit
messages: Golgi stack
messages: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP.

61622:CRABP1
gene id: 61622:CRABP1
uniprot id: A0A2K6QNW0
names: Function
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

61622:SH2B3
gene id: 61622:SH2B3
uniprot id: A0A2K6P0T8
names: Similarity
messages: Belongs to the SH2B adapter family.

61622:SEZ6
gene id: 61622:SEZ6
uniprot id: A0A2K6RR24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RHBDL2
gene id: 61622:RHBDL2
uniprot id: A0A2K6Q4Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

61622:HPS6
gene id: 61622:HPS6
uniprot id: A0A2K6NHR6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Interacts with HPS5 and HPS3. Interacts with biogenesis of lysosome-related organelles complex-1 (BLOC1). Interacts with AP-3 complex.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: Microsome membrane

61622:ZCCHC4
gene id: 61622:ZCCHC4
uniprot id: A0A2K6N949
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC4 family.
messages: Cytoplasm
messages: nucleolus

61622:DNASE1L3
gene id: 61622:DNASE1L3
uniprot id: A0A2K6RNW1
names: Similarity
messages: Belongs to the DNase I family.

61622:UBE2E2
gene id: 61622:UBE2E2
uniprot id: A0A2K6P2U9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:DDX58
gene id: 61622:DDX58
uniprot id: A0A2K6P0Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

61622:ICOS
gene id: 61622:ICOS
uniprot id: A0A2K6QJK8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

61622:PSMA4
gene id: 61622:PSMA4
uniprot id: A0A2K6QX52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:LOC104657698
gene id: 61622:LOC104657698
uniprot id: A0A2K6QEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:TMEM35A
gene id: 61622:TMEM35A
uniprot id: A0A2K6PBR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

61622:NDUFS4
gene id: 61622:NDUFS4
uniprot id: A0A2K6NDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

61622:LOC104668045
gene id: 61622:LOC104668045
uniprot id: A0A2K6Q0D1
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:SHCBP1
gene id: 61622:SHCBP1
uniprot id: A0A2K6RMC0
names: Subcellular Location Annotation
messages: spindle

61622:SMC6
gene id: 61622:SMC6
uniprot id: A0A2K6NLR4
names: Subcellular Location Annotation
messages: Chromosome

61622:F12
gene id: 61622:F12
uniprot id: A0A2K6NJR8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:FFAR1
gene id: 61622:FFAR1
uniprot id: A0A2K6NLT4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CLTRN
gene id: 61622:CLTRN
uniprot id: A0A2K6P148
names: Subcellular Location Annotation
messages: Membrane

61622:NEK6
gene id: 61622:NEK6
uniprot id: A0A2K6R1N4
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:BCL7C
gene id: 61622:BCL7C
uniprot id: A0A2K6QYQ1
names: Similarity
messages: Belongs to the BCL7 family.

61622:AMOTL1
gene id: 61622:AMOTL1
uniprot id: A0A2K6RQD2
uniprot id: A0A2K6RQG0
names: Similarity
messages: Belongs to the angiomotin family.

61622:FAM83C
gene id: 61622:FAM83C
uniprot id: A0A2K6R0Y4
names: Similarity
messages: Belongs to the FAM83 family.

61622:KRT222
gene id: 61622:KRT222
uniprot id: A0A2K6NB10
names: Similarity
messages: Belongs to the intermediate filament family.

61622:NSMCE4A
gene id: 61622:NSMCE4A
uniprot id: A0A2K6Q0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

61622:OC90
gene id: 61622:OC90
uniprot id: A0A2K6RIA5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:TIGD2
gene id: 61622:TIGD2
uniprot id: A0A2K6QFD2
names: Subcellular Location Annotation
messages: Nucleus

61622:HBS1L
gene id: 61622:HBS1L
uniprot id: A0A2K6NR58
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Interacts with the SKI complex.

61622:IRX3
gene id: 61622:IRX3
uniprot id: A0A2K6PR44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

61622:ELAC2
gene id: 61622:ELAC2
uniprot id: A0A2K6PPB8
names: Similarity
messages: Belongs to the RNase Z family.

61622:MRPL10
gene id: 61622:MRPL10
uniprot id: A0A2K6PTT8
uniprot id: A0A2K6PTV0
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

61622:LOC104674444
gene id: 61622:LOC104674444
uniprot id: A0A2K6N932
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

61622:AVP
gene id: 61622:AVP
uniprot id: A0A2K6PBA0
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

61622:ESRP1
gene id: 61622:ESRP1
uniprot id: A0A2K6NUZ9
uniprot id: A0A2K6NV01
uniprot id: A0A2K6NV05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

61622:CCNB2
gene id: 61622:CCNB2
uniprot id: A0A2K6PB66
names: Similarity
messages: Belongs to the cyclin family.

61622:QPRT
gene id: 61622:QPRT
uniprot id: A0A2K6NTX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

61622:CCDC172
gene id: 61622:CCDC172
uniprot id: A0A2K6QTF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC172 family.
messages: Cytoplasm

61622:TLX3
gene id: 61622:TLX3
uniprot id: A0A2K6PY45
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC35A2
gene id: 61622:SLC35A2
uniprot id: A0A2K6QWS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Membrane

61622:PNP
gene id: 61622:PNP
uniprot id: A0A2K6PE21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

61622:SLC30A10
gene id: 61622:SLC30A10
uniprot id: A0A2K6QU62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:THOC6
gene id: 61622:THOC6
uniprot id: A0A2K6QVA6
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

61622:SF3B1
gene id: 61622:SF3B1
uniprot id: A0A2K6PCH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

61622:CDH13
gene id: 61622:CDH13
uniprot id: A0A2K6R611
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.
messages: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
messages: Cell membrane
messages: Membrane

61622:CSNK1A1
gene id: 61622:CSNK1A1
uniprot id: A0A2K6PMK1
uniprot id: A0A2K6PMM4
uniprot id: A0A2K6PMT0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:GARS1
gene id: 61622:GARS1
uniprot id: A0A2K6RPT6
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

61622:ERGIC3
gene id: 61622:ERGIC3
uniprot id: A0A2K6PNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

61622:SDHAF4
gene id: 61622:SDHAF4
uniprot id: A0A2K6QVX0
names: Similarity
messages: Belongs to the SDHAF4 family.

61622:SEMA7A
gene id: 61622:SEMA7A
uniprot id: A0A2K6RFR9
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CRYGA
gene id: 61622:CRYGA
uniprot id: A0A2K6NE74
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:XKR9
gene id: 61622:XKR9
uniprot id: A0A2K6P445
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61622:PPBP
gene id: 61622:PPBP
uniprot id: A0A2K6QGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:GPR12
gene id: 61622:GPR12
uniprot id: A0A2K6ND89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:MED22
gene id: 61622:MED22
uniprot id: A0A2K6Q080
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

61622:FGR
gene id: 61622:FGR
uniprot id: A0A2K6QWA4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:MYO5C
gene id: 61622:MYO5C
uniprot id: A0A2K6RNF1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:FGF22
gene id: 61622:FGF22
uniprot id: A0A2K6NRM0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:UCP3
gene id: 61622:UCP3
uniprot id: A0A2K6Q629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:ST3GAL6
gene id: 61622:ST3GAL6
uniprot id: A0A2K6QRL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:HTR2B
gene id: 61622:HTR2B
uniprot id: A0A2K6QRB5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts (via C-terminus) with MPDZ.
messages: Membrane
messages: synaptosome

61622:FAM3A
gene id: 61622:FAM3A
uniprot id: A0A2K6RGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

61622:ADGRG7
gene id: 61622:ADGRG7
uniprot id: A0A2K6PYW3
names: Subcellular Location Annotation
messages: Membrane

61622:RAB39B
gene id: 61622:RAB39B
uniprot id: A0A2K6N7B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

61622:PLRG1
gene id: 61622:PLRG1
uniprot id: A0A2K6RTS2
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

61622:ALG3
gene id: 61622:ALG3
uniprot id: A0A2K6RWX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:NR2E1
gene id: 61622:NR2E1
uniprot id: A0A2K6RQ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:PPA2
gene id: 61622:PPA2
uniprot id: A0A2K6QYP1
uniprot id: A0A2K6QYP7
uniprot id: A0A2K6QYQ2
uniprot id: A0A2K6QYT1
uniprot id: A0A2K6QYT4
names: Similarity
messages: Belongs to the PPase family.

61622:ADRB3
gene id: 61622:ADRB3
uniprot id: A0A2K6NDK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
messages: Cell membrane
messages: Interacts with ARRDC3.
messages: Membrane

61622:MRPL19
gene id: 61622:MRPL19
uniprot id: A0A2K6RJX9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

61622:FTHL17
gene id: 61622:FTHL17
uniprot id: A0A2K6QFJ2
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:PDE1B
gene id: 61622:PDE1B
uniprot id: A0A2K6R2F5
uniprot id: A0A2K6R2I7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:LOC104676137
gene id: 61622:LOC104676137
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:LOC104671023
gene id: 61622:LOC104671023
uniprot id: A0A2K6NU81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:DIS3
gene id: 61622:DIS3
uniprot id: A0A2K6NFL6
uniprot id: A0A2K6NFL8
names: Similarity
messages: Belongs to the RNR ribonuclease family.

61622:C8H1orf74
gene id: 61622:C8H1orf74
uniprot id: A0A2K6NA18
names: Similarity
messages: Belongs to the UPF0739 family.

61622:ERC1
gene id: 61622:ERC1
uniprot id: A0A2K6QGV5
uniprot id: A0A2K6QGX2
names: Subcellular Location Annotation
messages: Cytoplasm

61622:JAK1
gene id: 61622:JAK1
uniprot id: A0A2K6RHP9
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

61622:CNN3
gene id: 61622:CNN3
uniprot id: A0A2K6P815
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

61622:TBCCD1
gene id: 61622:TBCCD1
uniprot id: A0A2K6REP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCC family.
messages: centrosome
messages: spindle pole

61622:TMED1
gene id: 61622:TMED1
uniprot id: A0A2K6NRG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61622:GTPBP1
gene id: 61622:GTPBP1
uniprot id: A0A2K6RQN5
names: Function
messages: Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.

61622:MRPS15
gene id: 61622:MRPS15
uniprot id: A0A2K6RVB2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

61622:ZPR1
gene id: 61622:ZPR1
uniprot id: A0A2K6N7D1
names: Similarity
messages: Belongs to the ZPR1 family.

61622:ABCC1
gene id: 61622:ABCC1
uniprot id: A0A2K6QY63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

61622:ELSPBP1
gene id: 61622:ELSPBP1
uniprot id: A0A2K6R9U4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:YIF1A
gene id: 61622:YIF1A
uniprot id: A0A2K6R650
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

61622:PSMD6
gene id: 61622:PSMD6
uniprot id: A0A2K6RAZ9
uniprot id: A0A2K6RB12
names: Similarity
messages: Belongs to the proteasome subunit S10 family.

61622:CBX3
gene id: 61622:CBX3
uniprot id: A0A2K6Q394
names: Subcellular Location Annotation
messages: Nucleus

61622:BLOC1S2
gene id: 61622:BLOC1S2
uniprot id: A0A2K6RLX9
names: Similarity
messages: Belongs to the BLOC1S2 family.

61622:NEDD8
gene id: 61622:NEDD8
uniprot id: A0A2K6Q6C6
names: Similarity
messages: Belongs to the ubiquitin family.

61622:TRIM22
gene id: 61622:TRIM22
uniprot id: A0A2K6Q5S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

61622:SCTR
gene id: 61622:SCTR
uniprot id: A0A2K6RF70
names: Subcellular Location Annotation
messages: Membrane

61622:LIF
gene id: 61622:LIF
uniprot id: A0A2K6N7J8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

61622:BOLA3
gene id: 61622:BOLA3
uniprot id: A0A2K6P4Y3
names: Similarity
messages: Belongs to the BolA/IbaG family.

61622:PARP3
gene id: 61622:PARP3
uniprot id: A0A2K6PT99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

61622:S100A4
gene id: 61622:S100A4
uniprot id: A0A2K6PII4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

61622:ACOX2
gene id: 61622:ACOX2
uniprot id: A0A2K6R963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

61622:AP3B1
gene id: 61622:AP3B1
uniprot id: A0A2K6PRD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes large subunit family.
messages: Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
messages: clathrin-coated vesicle membrane

61622:LY6D
gene id: 61622:LY6D
uniprot id: A0A2K6RKA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:AEBP1
gene id: 61622:AEBP1
uniprot id: A0A2K6R5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

61622:CNOT9
gene id: 61622:CNOT9
uniprot id: A0A2K6RN34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

61622:CASC3
gene id: 61622:CASC3
uniprot id: A0A2K6NMD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Nucleus speckle
messages: dendrite
messages: perinuclear region

61622:DEFB121
gene id: 61622:DEFB121
uniprot id: A0A2K6NCI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:ATP6V0A4
gene id: 61622:ATP6V0A4
uniprot id: A0A2K6QFY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

61622:LTF
gene id: 61622:LTF
uniprot id: A0A2K6P090
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferrin family.
messages: Cytoplasmic granule
messages: Secreted
messages: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

61622:LOC104674965
gene id: 61622:LOC104674965
uniprot id: A0A2K6QD00
names: Similarity
messages: Belongs to the PRAME family.

61622:OTUB1
gene id: 61622:OTUB1
uniprot id: A0A2K6R774
names: Similarity
messages: Belongs to the peptidase C65 family.

61622:ITGA8
gene id: 61622:ITGA8
uniprot id: A0A2K6RPE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:PPT1
gene id: 61622:PPT1
uniprot id: A0A2K6NKJ7
uniprot id: A0A2K6NKL4
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

61622:LOC104654854
gene id: 61622:LOC104654854
uniprot id: A0A2K6R8K7
names: Subcellular Location Annotation
messages: Membrane

61622:PRKCE
gene id: 61622:PRKCE
uniprot id: A0A2K6NZ12
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration.
messages: Cell membrane
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: cytoskeleton
messages: perinuclear region

61622:TARBP2
gene id: 61622:TARBP2
uniprot id: A0A2K6RR16
uniprot id: A0A2K6RR32
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

61622:DOK4
gene id: 61622:DOK4
uniprot id: A0A2K6PW78
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

61622:CCDC65
gene id: 61622:CCDC65
uniprot id: A0A2K6NZA6
names: Subcellular Location Annotation
names: Subunit
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: flagellum axoneme

61622:RHBDD2
gene id: 61622:RHBDD2
uniprot id: A0A2K6QYQ3
names: Subcellular Location Annotation
messages: Membrane

61622:DDX4
gene id: 61622:DDX4
uniprot id: A0A2K6RV64
uniprot id: A0A2K6RV71
uniprot id: A0A2K6RV80
uniprot id: A0A2K6RV88
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:NEMP1
gene id: 61622:NEMP1
uniprot id: A0A2K6PLE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

61622:GJD2
gene id: 61622:GJD2
uniprot id: A0A2K6QDU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:EXOC8
gene id: 61622:EXOC8
uniprot id: A0A2K6N828
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

61622:EPS8L1
gene id: 61622:EPS8L1
uniprot id: A0A2K6QQ14
names: Similarity
messages: Belongs to the EPS8 family.

61622:LOC104660643
gene id: 61622:LOC104660643
uniprot id: A0A2K6NHN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

61622:IP6K2
gene id: 61622:IP6K2
uniprot id: A0A2K6PBM6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:DLL1
gene id: 61622:DLL1
uniprot id: A0A2K6P7J9
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

61622:SSBP1
gene id: 61622:SSBP1
uniprot id: A0A2K6P020
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

61622:PFN4
gene id: 61622:PFN4
uniprot id: A0A2K6R730
names: Similarity
messages: Belongs to the profilin family.

61622:EIF4EBP2
gene id: 61622:EIF4EBP2
uniprot id: A0A2K6R4M8
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

61622:IPO9
gene id: 61622:IPO9
uniprot id: A0A2K6RTS4
names: Subcellular Location Annotation
messages: Cytoplasm

61622:YWHAE
gene id: 61622:YWHAE
uniprot id: A0A2K6QTN2
uniprot id: A0A2K6QTN5
names: Similarity
messages: Belongs to the 14-3-3 family.

61622:GPR183
gene id: 61622:GPR183
uniprot id: A0A2K6NDS3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:STAC
gene id: 61622:STAC
uniprot id: A0A2K6PBL4
names: Subcellular Location Annotation
messages: sarcolemma

61622:PPM1K
gene id: 61622:PPM1K
uniprot id: A0A2K6PMZ3
names: Similarity
messages: Belongs to the PP2C family.

61622:KDM5C
gene id: 61622:KDM5C
uniprot id: A0A2K6QJ20
uniprot id: A0A2K6QJ22
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

61622:DHRS9
gene id: 61622:DHRS9
uniprot id: A0A2K6QFB8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:SUSD6
gene id: 61622:SUSD6
uniprot id: A0A2K6QVZ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104667408
gene id: 61622:LOC104667408
uniprot id: A0A2K6Q9P7
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Theta family.
messages: Homodimer.

61622:TRIM34
gene id: 61622:TRIM34
uniprot id: A0A2K6QIQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRIM/RBCC family.
messages: Nucleus

61622:USP10
gene id: 61622:USP10
uniprot id: A0A2K6NB54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

61622:ACTR8
gene id: 61622:ACTR8
uniprot id: A0A2K6RCA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

61622:CD4
gene id: 61622:CD4
uniprot id: A0A2K6NUB6
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Forms disulfide-linked homodimers at the cell surface. Interacts with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI. Interacts with IL16; this interaction induces a CD4-dependent signaling in lymphocytes. Interacts (via Ig-like V-type domain) with MHCII alpha chain (via alpha-2 domain) and beta chain (via beta-2 domain); this interaction increases the affinity of TCR for peptide-MHCII. CD4 oligomerization via Ig-like C2-type 2 and 3 domains appears to be required for stable binding to MHCII and adhesion between T cells and APCs.

61622:BICD1
gene id: 61622:BICD1
uniprot id: A0A2K6NYW7
names: Similarity
messages: Belongs to the BicD family.

61622:SNTA1
gene id: 61622:SNTA1
uniprot id: A0A2K6RBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

61622:XRCC6
gene id: 61622:XRCC6
uniprot id: A0A2K6P5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

61622:PKN2
gene id: 61622:PKN2
uniprot id: A0A2K6PV29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cleavage furrow
messages: Midbody
messages: Nucleus

61622:NHSL1
gene id: 61622:NHSL1
uniprot id: A0A2K6NAT1
names: Similarity
messages: Belongs to the NHS family.

61622:LOC104664941
gene id: 61622:LOC104664941
uniprot id: A0A2K6QLJ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:HTRA4
gene id: 61622:HTRA4
uniprot id: A0A2K6QLT8
names: Similarity
messages: Belongs to the peptidase S1C family.

61622:TMED10
gene id: 61622:TMED10
uniprot id: A0A2K6PUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TIPIN
gene id: 61622:TIPIN
uniprot id: A0A2K6NA06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

61622:LRRC14
gene id: 61622:LRRC14
uniprot id: A0A2K6RPH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRAME family. LRRC14 subfamily.
messages: Cytoplasm

61622:POLR3G
gene id: 61622:POLR3G
uniprot id: A0A2K6R4Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61622:RASGRP2
gene id: 61622:RASGRP2
uniprot id: A0A2K6NIB8
names: Similarity
messages: Belongs to the RASGRP family.

61622:NEU4
gene id: 61622:NEU4
uniprot id: A0A2K6NDK0
uniprot id: A0A2K6NDK1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61622:LOC104660018
gene id: 61622:LOC104660018
uniprot id: A0A2K6RW52
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

61622:AMDHD1
gene id: 61622:AMDHD1
uniprot id: A0A2K6NXQ4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

61622:LOC104675814
gene id: 61622:LOC104675814
uniprot id: A0A2K6NAE4
names: Function
names: Similarity
messages: Belongs to the SSX family.
messages: Could act as a modulator of transcription.

61622:ATP6V0B
gene id: 61622:ATP6V0B
uniprot id: A0A2K6Q645
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

61622:STC1
gene id: 61622:STC1
uniprot id: A0A2K6RA96
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

61622:NUP98
gene id: 61622:NUP98
uniprot id: A0A2K6PFH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

61622:MCM5
gene id: 61622:MCM5
uniprot id: A0A2K6PW73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

61622:PKLR
gene id: 61622:PKLR
uniprot id: A0A2K6QEV0
names: Similarity
messages: Belongs to the pyruvate kinase family.

61622:ZC3H12A
gene id: 61622:ZC3H12A
uniprot id: A0A2K6QEV1
names: Similarity
messages: Belongs to the ZC3H12 family.

61622:IL12A
gene id: 61622:IL12A
uniprot id: A0A2K6REW5
uniprot id: A0A2K6REW7
uniprot id: A0A2K6REX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.
messages: Secreted

61622:HOXA2
gene id: 61622:HOXA2
uniprot id: A0A2K6RG50
names: Subcellular Location Annotation
messages: Nucleus

61622:TGFB2
gene id: 61622:TGFB2
uniprot id: A0A2K6QVN2
uniprot id: A0A2K6QVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

61622:MMRN1
gene id: 61622:MMRN1
uniprot id: A0A2K6R803
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HSPA13
gene id: 61622:HSPA13
uniprot id: A0A2K6Q6T3
uniprot id: A0A2K6Q6T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds UBQLN2.
messages: Endoplasmic reticulum
messages: Has peptide-independent ATPase activity.
messages: Microsome

61622:HNRNPF
gene id: 61622:HNRNPF
uniprot id: A0A2K6N7Y1
names: Subcellular Location Annotation
messages: nucleoplasm

61622:FXN
gene id: 61622:FXN
uniprot id: A0A2K6NML7
names: Similarity
messages: Belongs to the frataxin family.

61622:CENPS
gene id: 61622:CENPS
uniprot id: A0A2K6N705
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

61622:KCNAB3
gene id: 61622:KCNAB3
uniprot id: A0A2K6QWA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cytoplasm
messages: Monomer.

61622:HIBADH
gene id: 61622:HIBADH
uniprot id: A0A2K6NKB0
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

61622:YARS2
gene id: 61622:YARS2
uniprot id: A0A2K6QHH6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:XPO4
gene id: 61622:XPO4
uniprot id: A0A2K6PXU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Nucleus

61622:SLC39A2
gene id: 61622:SLC39A2
uniprot id: A0A2K6PKE9
names: Subcellular Location Annotation
messages: Membrane

61622:TOP2B
gene id: 61622:TOP2B
uniprot id: A0A2K6P3X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

61622:GGT6
gene id: 61622:GGT6
uniprot id: A0A2K6R4W3
names: Similarity
messages: Belongs to the gamma-glutamyltransferase family.

61622:SLC52A2
gene id: 61622:SLC52A2
uniprot id: A0A2K6PNE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

61622:KCTD13
gene id: 61622:KCTD13
uniprot id: A0A2K6RIT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

61622:POMK
gene id: 61622:POMK
uniprot id: A0A2K6P0V7
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

61622:TAS1R1
gene id: 61622:TAS1R1
uniprot id: A0A0M5LKU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104659546
gene id: 61622:LOC104659546
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:P2RX3
gene id: 61622:P2RX3
uniprot id: A0A2K6QPJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61622:ABHD2
gene id: 61622:ABHD2
uniprot id: A0A2K6QIG8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

61622:ARPC4
gene id: 61622:ARPC4
uniprot id: A0A2K6QVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

61622:FOXI1
gene id: 61622:FOXI1
uniprot id: A0A2K6QSM6
names: Subcellular Location Annotation
messages: Nucleus

61622:NAALADL1
gene id: 61622:NAALADL1
uniprot id: A0A2K6R5Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

61622:CHMP2A
gene id: 61622:CHMP2A
uniprot id: A0A2K6P0Y5
names: Similarity
messages: Belongs to the SNF7 family.

61622:TOR2A
gene id: 61622:TOR2A
uniprot id: A0A2K6PJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

61622:ARL1
gene id: 61622:ARL1
uniprot id: A0A2K6QI12
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:KCNK18
gene id: 61622:KCNK18
uniprot id: A0A2K6RBJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

61622:NUS1
gene id: 61622:NUS1
uniprot id: A0A2K6PXT8
names: Similarity
messages: Belongs to the UPP synthase family.

61622:PRAF2
gene id: 61622:PRAF2
uniprot id: A0A2K6PSX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

61622:SMC1B
gene id: 61622:SMC1B
uniprot id: A0A2K6PJD7
uniprot id: A0A2K6PJE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Chromosome
messages: Nucleus

61622:THTPA
gene id: 61622:THTPA
uniprot id: A0A2K6PHC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

61622:TMEM87B
gene id: 61622:TMEM87B
uniprot id: A0A2K6QMJ2
names: Subcellular Location Annotation
messages: Membrane

61622:SCGB2B2
gene id: 61622:SCGB2B2
uniprot id: A0A2K6P6G6
names: Subcellular Location Annotation
messages: Secreted

61622:KRT73
gene id: 61622:KRT73
uniprot id: A0A2K6P5T7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:BCKDK
gene id: 61622:BCKDK
uniprot id: A0A2K6N903
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:EBAG9
gene id: 61622:EBAG9
uniprot id: A0A2K6NM72
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

61622:RNF40
gene id: 61622:RNF40
uniprot id: A0A2K6N8F8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

61622:LOC104664037
gene id: 61622:LOC104664037
uniprot id: A0A2K6QT05
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:TM6SF1
gene id: 61622:TM6SF1
uniprot id: A0A2K6RST8
names: Subcellular Location Annotation
messages: Membrane

61622:HS6ST1
gene id: 61622:HS6ST1
uniprot id: A0A2K6QWG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
messages: Belongs to the sulfotransferase 6 family.
messages: Membrane

61622:MKRN2
gene id: 61622:MKRN2
uniprot id: A0A2K6PSN0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:BCLAF1
gene id: 61622:BCLAF1
uniprot id: A0A2K6QXB5
uniprot id: A0A2K6QXG4
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

61622:CEP57
gene id: 61622:CEP57
uniprot id: A0A2K6NL09
names: Similarity
messages: Belongs to the translokin family.

61622:LOC104674018
gene id: 61622:LOC104674018
uniprot id: A0A2K6NR30
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61622:PNPLA6
gene id: 61622:PNPLA6
uniprot id: A0A2K6NLR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CLPP
gene id: 61622:CLPP
uniprot id: A0A2K6R877
names: Similarity
messages: Belongs to the peptidase S14 family.

61622:TMEM184B
gene id: 61622:TMEM184B
uniprot id: A0A2K6QXV6
names: Subcellular Location Annotation
messages: Membrane

61622:ALDH1A1
gene id: 61622:ALDH1A1
uniprot id: A0A2K6Q6D7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:DGUOK
gene id: 61622:DGUOK
uniprot id: A0A2K6NYL0
uniprot id: A0A2K6NYL3
names: Similarity
messages: Belongs to the DCK/DGK family.

61622:VRK1
gene id: 61622:VRK1
uniprot id: A0A2K6PNE5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SLC25A17
gene id: 61622:SLC25A17
uniprot id: A0A2K6P6F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:TDRD5
gene id: 61622:TDRD5
uniprot id: A0A2K6RV66
uniprot id: A0A2K6RV77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDRD5 family.
messages: Cytoplasm
messages: Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.

61622:SNX5
gene id: 61622:SNX5
uniprot id: A0A2K6PAB6
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

61622:HPS3
gene id: 61622:HPS3
uniprot id: A0A2K6NDN4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: Cytoplasm
messages: Involved in early stages of melanosome biogenesis and maturation.

61622:LOC104679055
gene id: 61622:LOC104679055
uniprot id: A0A2K6QIQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:HYAL1
gene id: 61622:HYAL1
uniprot id: A0A2K6PBY3
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

61622:PNOC
gene id: 61622:PNOC
uniprot id: A0A2K6PZD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

61622:CA1
gene id: 61622:CA1
uniprot id: A0A2K6QFJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

61622:LOC104668916
gene id: 61622:LOC104668916
uniprot id: A0A2K6PR37
names: Similarity
messages: Belongs to the PRAME family.

61622:IDH3B
gene id: 61622:IDH3B
uniprot id: A0A2K6NQG2
uniprot id: A0A2K6NQG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

61622:KHDC1L
gene id: 61622:KHDC1L
uniprot id: A0A2K6N8L5
names: Similarity
messages: Belongs to the KHDC1 family.

61622:MCCC2
gene id: 61622:MCCC2
uniprot id: A0A2K6QFL4
names: Similarity
messages: Belongs to the AccD/PCCB family.

61622:TRMT13
gene id: 61622:TRMT13
uniprot id: A0A2K6RL63
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

61622:KCNE2
gene id: 61622:KCNE2
uniprot id: A0A2K6N994
names: Similarity
messages: Belongs to the potassium channel KCNE family.

61622:ARHGEF3
gene id: 61622:ARHGEF3
uniprot id: A0A2K6QAZ1
uniprot id: A0A2K6QAZ6
uniprot id: A0A2K6QAZ7
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

61622:HEG1
gene id: 61622:HEG1
uniprot id: A0A2K6PSH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HACD1
gene id: 61622:HACD1
uniprot id: A0A2K6NR84
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:EI24
gene id: 61622:EI24
uniprot id: A0A2K6P4S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EI24 family.
messages: Membrane

61622:CACNG3
gene id: 61622:CACNG3
uniprot id: A0A2K6QPP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane

61622:TMEM132B
gene id: 61622:TMEM132B
uniprot id: A0A2K6PUB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

61622:ITPK1
gene id: 61622:ITPK1
uniprot id: A0A2K6RPP9
names: Similarity
messages: Belongs to the ITPK1 family.

61622:ALDH9A1
gene id: 61622:ALDH9A1
uniprot id: A0A2K6QIU9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:COL4A4
gene id: 61622:COL4A4
uniprot id: A0A2K6PCA1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:HAGHL
gene id: 61622:HAGHL
uniprot id: A0A2K6PVJ4
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

61622:TM9SF3
gene id: 61622:TM9SF3
uniprot id: A0A2K6QMN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

61622:HDAC3
gene id: 61622:HDAC3
uniprot id: A0A2K6NRH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

61622:TNFSF13
gene id: 61622:TNFSF13
uniprot id: A0A2K6REC9
uniprot id: A0A2K6RED3
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:MPHOSPH10
gene id: 61622:MPHOSPH10
uniprot id: A0A2K6PUM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

61622:GRN
gene id: 61622:GRN
uniprot id: A0A2K6NI24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the granulin family.
messages: Secreted

61622:FAM214A
gene id: 61622:FAM214A
uniprot id: A0A2K6PFV2
names: Similarity
messages: Belongs to the FAM214 family.

61622:SLC25A33
gene id: 61622:SLC25A33
uniprot id: A0A2K6RAJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:AARS1
gene id: 61622:AARS1
uniprot id: A0A2K6NSV0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

61622:NPB
gene id: 61622:NPB
uniprot id: A0A2K6PF05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

61622:PIP4P2
gene id: 61622:PIP4P2
uniprot id: A0A2K6R340
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

61622:RSBN1L
gene id: 61622:RSBN1L
uniprot id: A0A2K6QTE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

61622:VDAC1
gene id: 61622:VDAC1
uniprot id: A0A2K6NQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft

61622:LOC104654463
gene id: 61622:LOC104654463
uniprot id: A0A2K6NQW7
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:BMP7
gene id: 61622:BMP7
uniprot id: A0A2K6NCU1
names: Similarity
messages: Belongs to the TGF-beta family.

61622:HOXB6
gene id: 61622:HOXB6
uniprot id: A0A2K6NU66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:SLC7A7
gene id: 61622:SLC7A7
uniprot id: A0A2K6QAC3
names: Subcellular Location Annotation
messages: Membrane

61622:SUGP2
gene id: 61622:SUGP2
uniprot id: A0A2K6NZG4
names: Subcellular Location Annotation
messages: Nucleus

61622:P3H2
gene id: 61622:P3H2
uniprot id: A0A2K6PBI0
names: Similarity
messages: Belongs to the leprecan family.

61622:CD163
gene id: 61622:CD163
uniprot id: A0A2K6PQB6
uniprot id: A0A2K6PQC3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:FAP
gene id: 61622:FAP
uniprot id: A0A2K6QDI2
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

61622:SH3RF2
gene id: 61622:SH3RF2
uniprot id: A0A2K6RLZ6
names: Similarity
messages: Belongs to the SH3RF family.

61622:PTGFR
gene id: 61622:PTGFR
uniprot id: A0A2K6PE36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:RING1
gene id: 61622:RING1
uniprot id: A0A2K6PPQ5
names: Function
names: Subcellular Location Annotation
messages: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
messages: Nucleus speckle

61622:NUBP1
gene id: 61622:NUBP1
uniprot id: A0A2K6P6P8
uniprot id: A0A2K6P6T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Cell projection
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.

61622:KRT1
gene id: 61622:KRT1
uniprot id: A0A2K6RDQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61622:NOTCH2
gene id: 61622:NOTCH2
uniprot id: A0A2K6QH44
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

61622:GTF2I
gene id: 61622:GTF2I
uniprot id: A0A2K6PWT9
uniprot id: A0A2K6PWU7
names: Subcellular Location Annotation
messages: Nucleus

61622:PACS1
gene id: 61622:PACS1
uniprot id: A0A2K6Q7Y2
uniprot id: A0A2K6Q800
names: Similarity
messages: Belongs to the PACS family.

61622:ASPN
gene id: 61622:ASPN
uniprot id: A0A2K6NNC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

61622:UBAC2
gene id: 61622:UBAC2
uniprot id: A0A2K6R293
names: Subcellular Location Annotation
messages: Membrane

61622:INPP5J
gene id: 61622:INPP5J
uniprot id: A0A2K6PII5
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

61622:IFNG
gene id: 61622:IFNG
uniprot id: A0A2K6PM05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.

61622:MFAP1
gene id: 61622:MFAP1
uniprot id: A0A2K6QL46
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

61622:ACRBP
gene id: 61622:ACRBP
uniprot id: A0A2K6Q9F8
names: Subcellular Location Annotation
messages: acrosome

61622:COPS5
gene id: 61622:COPS5
uniprot id: A0A2K6R4J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

61622:CTNNBL1
gene id: 61622:CTNNBL1
uniprot id: A0A2K6R8P1
names: Subcellular Location Annotation
messages: Nucleus

61622:PSME3IP1
gene id: 61622:PSME3IP1
uniprot id: A0A2K6PZX7
names: Subcellular Location Annotation
messages: Nucleus

61622:ST8SIA6
gene id: 61622:ST8SIA6
uniprot id: A0A2K6RJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:GUCA2A
gene id: 61622:GUCA2A
uniprot id: A0A2K6NKY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

61622:RTN2
gene id: 61622:RTN2
uniprot id: A0A2K6QK29
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:KIF23
gene id: 61622:KIF23
uniprot id: A0A2K6NFV2
uniprot id: A0A2K6NFV4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:RRP1B
gene id: 61622:RRP1B
uniprot id: A0A2K6PDQ0
names: Similarity
messages: Belongs to the RRP1 family.

61622:PPM1D
gene id: 61622:PPM1D
uniprot id: A0A2K6QCZ0
names: Similarity
messages: Belongs to the PP2C family.

61622:CELF3
gene id: 61622:CELF3
uniprot id: A0A2K6RSF3
uniprot id: A0A2K6RSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

61622:THRB
gene id: 61622:THRB
uniprot id: A0A2K6NWI2
uniprot id: A0A2K6NWI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:NR5A1
gene id: 61622:NR5A1
uniprot id: A0A2K6RNY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

61622:EIF4A3
gene id: 61622:EIF4A3
uniprot id: A0A2K6R9V1
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:CD5L
gene id: 61622:CD5L
uniprot id: A0A2K6QC66
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PREPL
gene id: 61622:PREPL
uniprot id: A0A2K6R7L5
names: Similarity
messages: Belongs to the peptidase S9A family.

61622:CD59
gene id: 61622:CD59
uniprot id: A0A2K6NNU3
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Interacts with T-cell surface antigen CD2.
messages: Membrane

61622:ESRRA
gene id: 61622:ESRRA
uniprot id: A0A2K6QT08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

61622:APH1B
gene id: 61622:APH1B
uniprot id: A0A2K6NEY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the APH-1 family.
messages: Component of the gamma-secretase complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.

61622:EED
gene id: 61622:EED
uniprot id: A0A2K6PPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

61622:TARS2
gene id: 61622:TARS2
uniprot id: A0A2K6PAC4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:SLC37A2
gene id: 61622:SLC37A2
uniprot id: A0A2K6PAI5
uniprot id: A0A2K6PAQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

61622:AKR1E2
gene id: 61622:AKR1E2
uniprot id: A0A2K6QQA3
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:CLGN
gene id: 61622:CLGN
uniprot id: A0A2K6NSB1
names: Similarity
messages: Belongs to the calreticulin family.

61622:SENP8
gene id: 61622:SENP8
uniprot id: A0A2K6NJH0
names: Similarity
messages: Belongs to the peptidase C48 family.

61622:ALDH1A2
gene id: 61622:ALDH1A2
uniprot id: A0A2K6QKA6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:SGCB
gene id: 61622:SGCB
uniprot id: A0A2K6QSX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

61622:CHMP4C
gene id: 61622:CHMP4C
uniprot id: A0A2K6PER5
names: Similarity
messages: Belongs to the SNF7 family.

61622:DHCR7
gene id: 61622:DHCR7
uniprot id: A0A2K6R7K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

61622:TIGD6
gene id: 61622:TIGD6
uniprot id: A0A2K6NKK2
names: Subcellular Location Annotation
messages: Nucleus

61622:JAGN1
gene id: 61622:JAGN1
uniprot id: A0A2K6NAD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CFAP300
gene id: 61622:CFAP300
uniprot id: A0A2K6P9G0
uniprot id: A0A2K6P9G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

61622:PLA2G3
gene id: 61622:PLA2G3
uniprot id: A0A2K6RSX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Secreted

61622:LOC104677852
gene id: 61622:LOC104677852
uniprot id: A0A2K6NHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61622:ZNF213
gene id: 61622:ZNF213
uniprot id: A0A2K6PND2
names: Subcellular Location Annotation
messages: Nucleus

61622:PA2G4
gene id: 61622:PA2G4
uniprot id: A0A2K6NBE1
names: Similarity
messages: Belongs to the peptidase M24 family.

61622:C16H9orf64
gene id: 61622:C16H9orf64
uniprot id: A0A2K6Q404
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

61622:COPE
gene id: 61622:COPE
uniprot id: A0A2K6PIZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

61622:ATP5F1E
gene id: 61622:ATP5F1E
uniprot id: A0A2K6NHF0
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

61622:FGFR1
gene id: 61622:FGFR1
uniprot id: A0A2K6Q903
uniprot id: A0A2K6Q904
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

61622:TFCP2L1
gene id: 61622:TFCP2L1
uniprot id: A0A2K6QVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

61622:RPGRIP1L
gene id: 61622:RPGRIP1L
uniprot id: A0A2K6REL8
names: Similarity
messages: Belongs to the RPGRIP1 family.

61622:HNRNPDL
gene id: 61622:HNRNPDL
uniprot id: A0A2K6PVB3
uniprot id: A0A2K6PVB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:RPS21
gene id: 61622:RPS21
uniprot id: A0A2K6QLF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

61622:KRR1
gene id: 61622:KRR1
uniprot id: A0A2K6P1U6
uniprot id: A0A2K6P1V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: nucleolus

61622:ATF4
gene id: 61622:ATF4
uniprot id: A0A2K6NSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

61622:SNAPC4
gene id: 61622:SNAPC4
uniprot id: A0A2K6QH50
names: Subcellular Location Annotation
messages: Nucleus

61622:MFSD6L
gene id: 61622:MFSD6L
uniprot id: A0A2K6NBD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

61622:MAPK4
gene id: 61622:MAPK4
uniprot id: A0A2K6PCD8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

61622:AURKA
gene id: 61622:AURKA
uniprot id: A0A2K6QW84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

61622:DAND5
gene id: 61622:DAND5
uniprot id: A0A2K6PM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

61622:BLOC1S6
gene id: 61622:BLOC1S6
uniprot id: A0A2K6ND45
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

61622:NAXD
gene id: 61622:NAXD
uniprot id: A0A2K6RF68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Mitochondrion

61622:MAN2B1
gene id: 61622:MAN2B1
uniprot id: A0A2K6QUS4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

61622:ARPC2
gene id: 61622:ARPC2
uniprot id: A0A2K6NYH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

61622:NLK
gene id: 61622:NLK
uniprot id: A0A2K6P6C6
uniprot id: A0A2K6P6D5
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

61622:PRDX6
gene id: 61622:PRDX6
uniprot id: A0A2K6R212
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

61622:RAB39A
gene id: 61622:RAB39A
uniprot id: A0A2K6NXG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

61622:LOC104658856
gene id: 61622:LOC104658856
uniprot id: A0A2K6NXX5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:DENND5A
gene id: 61622:DENND5A
uniprot id: A0A2K6QZ23
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:NDUFAF7
gene id: 61622:NDUFAF7
uniprot id: A0A2K6RHZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

61622:GUK1
gene id: 61622:GUK1
uniprot id: A0A2K6PGH4
names: Similarity
messages: Belongs to the guanylate kinase family.

61622:RNPEP
gene id: 61622:RNPEP
uniprot id: A0A2K6RH43
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

61622:SEPTIN6
gene id: 61622:SEPTIN6
uniprot id: A0A2K6QM74
uniprot id: A0A2K6QM87
uniprot id: A0A2K6QM91
uniprot id: A0A2K6QM96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

61622:SRPX
gene id: 61622:SRPX
uniprot id: A0A2K6PD00
uniprot id: A0A2K6PD36
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RNFT2
gene id: 61622:RNFT2
uniprot id: A0A2K6P2T9
names: Subcellular Location Annotation
messages: Membrane

61622:RPL13
gene id: 61622:RPL13
uniprot id: A0A2K6QCL1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

61622:LOC104664125
gene id: 61622:LOC104664125
uniprot id: A0A2K6PRR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61622:WNT10B
gene id: 61622:WNT10B
uniprot id: A0A2K6RSD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:PGAM1
gene id: 61622:PGAM1
uniprot id: A0A2K6QTU3
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:TERT
gene id: 61622:TERT
uniprot id: A0A2K6PK27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: nucleolus
messages: nucleoplasm
messages: telomere

61622:TGM2
gene id: 61622:TGM2
uniprot id: A0A2K6Q284
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:TBC1D7
gene id: 61622:TBC1D7
uniprot id: A0A2K6QVL7
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

61622:CREB1
gene id: 61622:CREB1
uniprot id: A0A2K6Q2B5
uniprot id: A0A2K6Q2B9
names: Subcellular Location Annotation
messages: Nucleus

61622:AGA
gene id: 61622:AGA
uniprot id: A0A2K6NTT0
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

61622:SNRPD3
gene id: 61622:SNRPD3
uniprot id: A0A2K6PBE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as core component of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.
messages: cytosol

61622:IPPK
gene id: 61622:IPPK
uniprot id: A0A2K6PXR1
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

61622:BMP15
gene id: 61622:BMP15
uniprot id: A0A2K6QQR3
names: Similarity
messages: Belongs to the TGF-beta family.

61622:HOXB2
gene id: 61622:HOXB2
uniprot id: A0A2K6RRI2
names: Subcellular Location Annotation
messages: Nucleus

61622:PRKG2
gene id: 61622:PRKG2
uniprot id: A0A2K6PHI6
uniprot id: A0A2K6PHR0
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

61622:GPAM
gene id: 61622:GPAM
uniprot id: A0A2K6P320
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

61622:FAM98A
gene id: 61622:FAM98A
uniprot id: A0A2K6QH79
names: Similarity
messages: Belongs to the FAM98 family.

61622:YIPF4
gene id: 61622:YIPF4
uniprot id: A0A2K6RW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

61622:GGPS1
gene id: 61622:GGPS1
uniprot id: A0A2K6PHY0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61622:ALPL
gene id: 61622:ALPL
uniprot id: A0A2K6QDM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline phosphatase family.
messages: Cell membrane
messages: Membrane

61622:CCR7
gene id: 61622:CCR7
uniprot id: A0A2K6QMS3
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:WDR45
gene id: 61622:WDR45
uniprot id: A0A2K6PT05
uniprot id: A0A2K6PT12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Preautophagosomal structure

61622:KPNA4
gene id: 61622:KPNA4
uniprot id: A0A2K6NFI8
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:ST8SIA2
gene id: 61622:ST8SIA2
uniprot id: A0A2K6NJA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:NDRG4
gene id: 61622:NDRG4
uniprot id: A0A2K6QH32
uniprot id: A0A2K6QH38
uniprot id: A0A2K6QH41
uniprot id: A0A2K6QH57
uniprot id: A0A2K6QH62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: cytosol

61622:PYGB
gene id: 61622:PYGB
uniprot id: A0A2K6Q4J6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

61622:LOC104667649
gene id: 61622:LOC104667649
uniprot id: A0A2K6NQR9
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

61622:FAHD1
gene id: 61622:FAHD1
uniprot id: A0A2K6PMW5
names: Similarity
messages: Belongs to the FAH family.

61622:RP2
gene id: 61622:RP2
uniprot id: A0A2K6R4X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.
messages: Belongs to the TBCC family.
messages: Cell membrane
messages: Membrane

61622:KIF21B
gene id: 61622:KIF21B
uniprot id: A0A2K6Q3B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

61622:IPMK
gene id: 61622:IPMK
uniprot id: A0A2K6Q4K6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:EAF2
gene id: 61622:EAF2
uniprot id: A0A2K6P592
names: Similarity
messages: Belongs to the EAF family.

61622:NAAA
gene id: 61622:NAAA
uniprot id: A0A2K6P3D8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

61622:COQ4
gene id: 61622:COQ4
uniprot id: A0A2K6QZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

61622:ZDHHC21
gene id: 61622:ZDHHC21
uniprot id: A0A2K6NXY3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:CLK4
gene id: 61622:CLK4
uniprot id: A0A2K6RQ64
uniprot id: A0A2K6RQA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MRPL44
gene id: 61622:MRPL44
uniprot id: A0A2K6PHX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Mitochondrion

61622:PHLDA3
gene id: 61622:PHLDA3
uniprot id: A0A2K6NMW0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:RTF2
gene id: 61622:RTF2
uniprot id: A0A2K6PPK8
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

61622:PRDX5
gene id: 61622:PRDX5
uniprot id: A0A2K6NLQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Peroxisome matrix
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

61622:GLYAT
gene id: 61622:GLYAT
uniprot id: A0A2K6QF97
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61622:SENP5
gene id: 61622:SENP5
uniprot id: A0A2K6QFS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

61622:LPL
gene id: 61622:LPL
uniprot id: A0A2K6R7B5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

61622:DTX3
gene id: 61622:DTX3
uniprot id: A0A2K6RBS7
uniprot id: A0A2K6RBT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

61622:PAQR7
gene id: 61622:PAQR7
uniprot id: A0A2K6NIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:DOCK9
gene id: 61622:DOCK9
uniprot id: A0A2K6P9B6
names: Similarity
messages: Belongs to the DOCK family.

61622:DPP4
gene id: 61622:DPP4
uniprot id: A0A2K6RP32
names: Subcellular Location Annotation
messages: Cell membrane
messages: invadopodium membrane
messages: lamellipodium membrane

61622:MAPK3
gene id: 61622:MAPK3
uniprot id: A0A2K6QTM1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: caveola

61622:FLVCR1
gene id: 61622:FLVCR1
uniprot id: A0A2K6QBT9
names: Subcellular Location Annotation
messages: Membrane

61622:SFRP4
gene id: 61622:SFRP4
uniprot id: A0A2K6RU28
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TSSK2
gene id: 61622:TSSK2
uniprot id: A0A2K6N7M6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:ABI2
gene id: 61622:ABI2
uniprot id: A0A2K6R1C9
uniprot id: A0A2K6R1E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

61622:MDM1
gene id: 61622:MDM1
uniprot id: A0A2K6PFB6
uniprot id: A0A2K6PFH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

61622:MARVELD3
gene id: 61622:MARVELD3
uniprot id: A0A2K6QMZ7
uniprot id: A0A2K6QN02
names: Subcellular Location Annotation
messages: Membrane

61622:NUDT7
gene id: 61622:NUDT7
uniprot id: A0A2K6N9H9
uniprot id: A0A2K6N9J1
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

61622:NRDE2
gene id: 61622:NRDE2
uniprot id: A0A2K6QZ00
names: Similarity
messages: Belongs to the NRDE2 family.

61622:LOC104670703
gene id: 61622:LOC104670703
uniprot id: A0A2K6NCW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

61622:SYS1
gene id: 61622:SYS1
uniprot id: A0A2K6NQ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

61622:POMC
gene id: 61622:POMC
uniprot id: A0A2K6RV63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
messages: Belongs to the POMC family.
messages: Endogenous opiate.
messages: Endogenous orexigenic opiate.
messages: Secreted
messages: Stimulates the adrenal glands to release cortisol.

61622:CA5A
gene id: 61622:CA5A
uniprot id: A0A2K6RLY9
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61622:CANT1
gene id: 61622:CANT1
uniprot id: A0A2K6RGJ6
names: Similarity
messages: Belongs to the apyrase family.

61622:LOC104682480
gene id: 61622:LOC104682480
uniprot id: A0A2K6R8I0
names: Similarity
messages: Belongs to the apolipoprotein L family.

61622:LOC104655557
gene id: 61622:LOC104655557
uniprot id: A0A2K6QFG4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

61622:LOC104658369
gene id: 61622:LOC104658369
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:NT5DC2
gene id: 61622:NT5DC2
uniprot id: A0A2K6RJB6
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

61622:ARPC1B
gene id: 61622:ARPC1B
uniprot id: A0A2K6QQ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

61622:MDFI
gene id: 61622:MDFI
uniprot id: A0A2K6R5Q0
names: Similarity
messages: Belongs to the MDFI family.

61622:KXD1
gene id: 61622:KXD1
uniprot id: A0A2K6PTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

61622:ATP23
gene id: 61622:ATP23
uniprot id: A0A2K6QER7
names: Similarity
messages: Belongs to the peptidase M76 family.

61622:EPB41L5
gene id: 61622:EPB41L5
uniprot id: A0A2K6P8W4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Photoreceptor inner segment
messages: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.

61622:UBA2
gene id: 61622:UBA2
uniprot id: A0A2K6PGN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

61622:TUB
gene id: 61622:TUB
uniprot id: A0A2K6P623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

61622:DPF2
gene id: 61622:DPF2
uniprot id: A0A2K6Q9W0
names: Similarity
messages: Belongs to the requiem/DPF family.

61622:SLC6A4
gene id: 61622:SLC6A4
uniprot id: A0A2K6R6F6
uniprot id: A0A2K6R6G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Endosome membrane
messages: Membrane
messages: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
messages: Synapse
messages: focal adhesion

61622:TACC1
gene id: 61622:TACC1
uniprot id: A0A2K6QHZ6
uniprot id: A0A2K6QHZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

61622:DCP1A
gene id: 61622:DCP1A
uniprot id: A0A2K6REY3
names: Similarity
messages: Belongs to the DCP1 family.

61622:LOC104658905
gene id: 61622:LOC104658905
uniprot id: A0A2K6NCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

61622:MRPS18B
gene id: 61622:MRPS18B
uniprot id: A0A2K6NJ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

61622:GPRC5B
gene id: 61622:GPRC5B
uniprot id: A0A2K6RJZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:NONO
gene id: 61622:NONO
uniprot id: A0A2K6RFT5
names: Subcellular Location Annotation
messages: Nucleus speckle

61622:MOB3B
gene id: 61622:MOB3B
uniprot id: A0A2K6R0E6
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:SLC46A2
gene id: 61622:SLC46A2
uniprot id: A0A2K6PFX0
uniprot id: A0A2K6PFX8
names: Subcellular Location Annotation
messages: Membrane

61622:HSF2
gene id: 61622:HSF2
uniprot id: A0A2K6QGR1
uniprot id: A0A2K6QGR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:SMUG1
gene id: 61622:SMUG1
uniprot id: A0A2K6RBA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. SMUG1 family.
messages: Nucleus

61622:TGM4
gene id: 61622:TGM4
uniprot id: A0A2K6NKC9
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

61622:TVP23A
gene id: 61622:TVP23A
uniprot id: A0A2K6NU37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

61622:TNN
gene id: 61622:TNN
uniprot id: A0A2K6QD53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

61622:TEFM
gene id: 61622:TEFM
uniprot id: A0A2K6P6R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

61622:MAP1LC3C
gene id: 61622:MAP1LC3C
uniprot id: A0A2K6N8I7
names: Similarity
messages: Belongs to the ATG8 family.

61622:GNAI2
gene id: 61622:GNAI2
uniprot id: A0A2K6P008
uniprot id: A0A2K6P024
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61622:DESI1
gene id: 61622:DESI1
uniprot id: A0A2K6QQT7
names: Similarity
messages: Belongs to the DeSI family.

61622:COL4A3
gene id: 61622:COL4A3
uniprot id: A0A2K6NDV2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
messages: basement membrane

61622:MRPS23
gene id: 61622:MRPS23
uniprot id: A0A2K6Q0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

61622:RIOK2
gene id: 61622:RIOK2
uniprot id: A0A2K6QQC2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

61622:CHRM5
gene id: 61622:CHRM5
uniprot id: A0A2K6NSN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

61622:FAM162A
gene id: 61622:FAM162A
uniprot id: A0A2K6PLQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

61622:NINJ1
gene id: 61622:NINJ1
uniprot id: A0A2K6QJE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

61622:UBE2E3
gene id: 61622:UBE2E3
uniprot id: A0A2K6QTM7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:CNNM1
gene id: 61622:CNNM1
uniprot id: A0A2K6R7M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Membrane

61622:FLCN
gene id: 61622:FLCN
uniprot id: A0A2K6PQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

61622:HBA1
gene id: 61622:HBA1
uniprot id: A0A2K6R518
names: Similarity
messages: Belongs to the globin family.

61622:ADH4
gene id: 61622:ADH4
uniprot id: A0A2K6P0S6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.

61622:MED21
gene id: 61622:MED21
uniprot id: A0A2K6QC08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

61622:LOC104655732
gene id: 61622:LOC104655732
uniprot id: A0A2K6PDP4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

61622:BRMS1L
gene id: 61622:BRMS1L
uniprot id: A0A2K6QN00
names: Subcellular Location Annotation
messages: Nucleus

61622:EHHADH
gene id: 61622:EHHADH
uniprot id: A0A2K6R324
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

61622:STK40
gene id: 61622:STK40
uniprot id: A0A2K6NQF0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

61622:INSL4
gene id: 61622:INSL4
uniprot id: A0A2K6R335
names: Subcellular Location Annotation
messages: Secreted

61622:KIF1A
gene id: 61622:KIF1A
uniprot id: A0A2K6QS99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: axon

61622:HSPD1
gene id: 61622:HSPD1
uniprot id: A0A2K6PDP4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

61622:B4GALT3
gene id: 61622:B4GALT3
uniprot id: A0A2K6RVT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

61622:LIMK1
gene id: 61622:LIMK1
uniprot id: A0A2K6QZ40
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

61622:OGFOD1
gene id: 61622:OGFOD1
uniprot id: A0A2K6RHP0
names: Similarity
messages: Belongs to the TPA1 family.

61622:TLR8
gene id: 61622:TLR8
uniprot id: A0A2K6P591
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61622:SAP130
gene id: 61622:SAP130
uniprot id: A0A2K6QNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAP130 family.
messages: Nucleus

61622:CLTC
gene id: 61622:CLTC
uniprot id: A0A2K6QF57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

61622:MICOS13
gene id: 61622:MICOS13
uniprot id: A0A2K6PEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

61622:IP6K1
gene id: 61622:IP6K1
uniprot id: A0A2K6QQC6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:AQP9
gene id: 61622:AQP9
uniprot id: A0A2K6QAZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:NXT1
gene id: 61622:NXT1
uniprot id: A0A2K6NRL0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

61622:SEC62
gene id: 61622:SEC62
uniprot id: A0A2K6QZI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CASC4
gene id: 61622:CASC4
uniprot id: A0A2K6N7U9
uniprot id: A0A2K6N7V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

61622:ALG10
gene id: 61622:ALG10
uniprot id: A0A2K6NYC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TSPAN17
gene id: 61622:TSPAN17
uniprot id: A0A2K6QRZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:AMPD2
gene id: 61622:AMPD2
uniprot id: A0A2K6R8J8
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61622:FFAR2
gene id: 61622:FFAR2
uniprot id: A0A2K6NIL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:P3H1
gene id: 61622:P3H1
uniprot id: A0A2K6QJP7
names: Similarity
messages: Belongs to the leprecan family.

61622:FAM163A
gene id: 61622:FAM163A
uniprot id: A0A2K6P7D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM163 family.
messages: Membrane

61622:KPNA1
gene id: 61622:KPNA1
uniprot id: A0A2K6NKA3
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

61622:DRAM1
gene id: 61622:DRAM1
uniprot id: A0A2K6RQJ8
names: Subcellular Location Annotation
messages: Membrane

61622:HNF1A
gene id: 61622:HNF1A
uniprot id: A0A2K6NLC5
uniprot id: A0A2K6NLC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

61622:ZNF687
gene id: 61622:ZNF687
uniprot id: A0A2K6QDQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: May be involved in transcriptional regulation.
messages: Nucleus

61622:PDGFB
gene id: 61622:PDGFB
uniprot id: A0A2K6NBZ1
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

61622:SCD5
gene id: 61622:SCD5
uniprot id: A0A2K6QJA3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

61622:EDEM1
gene id: 61622:EDEM1
uniprot id: A0A2K6RNC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:OSM
gene id: 61622:OSM
uniprot id: A0A2K6QJG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: Secreted

61622:BACE1
gene id: 61622:BACE1
uniprot id: A0A2K6P448
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Membrane
messages: Membrane raft
messages: Recycling endosome
messages: Secreted
messages: trans-Golgi network

61622:IFNAR1
gene id: 61622:IFNAR1
uniprot id: A0A2K6PT61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II cytokine receptor family.
messages: Cell membrane
messages: Endosome
messages: Heterodimer with IFNAR2.
messages: Late endosome
messages: Lysosome
messages: Membrane
messages: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

61622:IL17RA
gene id: 61622:IL17RA
uniprot id: A0A2K6RAU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104664783
gene id: 61622:LOC104664783
uniprot id: A0A2K6PBJ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

61622:ING3
gene id: 61622:ING3
uniprot id: A0A2K6P2C8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:ADA
gene id: 61622:ADA
uniprot id: A0A2K6R9J0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Cell junction
messages: Cell membrane
messages: Cytoplasmic vesicle lumen

61622:SVBP
gene id: 61622:SVBP
uniprot id: A0A2K6QZP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Secreted
messages: cytoskeleton

61622:SRPRB
gene id: 61622:SRPRB
uniprot id: A0A2K6P7E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LOC104671564
gene id: 61622:LOC104671564
uniprot id: A0A2K6QS48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

61622:PYCR3
gene id: 61622:PYCR3
uniprot id: A0A2K6PWA0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61622:APOB
gene id: 61622:APOB
uniprot id: A0A2K6PZ21
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:HMGCR
gene id: 61622:HMGCR
uniprot id: A0A2K6QV04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

61622:PHKB
gene id: 61622:PHKB
uniprot id: A0A2K6PP62
uniprot id: A0A2K6PP74
uniprot id: A0A2K6PP95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

61622:SLC4A8
gene id: 61622:SLC4A8
uniprot id: A0A2K6RH75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Membrane

61622:CDK20
gene id: 61622:CDK20
uniprot id: A0A2K6NYZ2
uniprot id: A0A2K6NYZ6
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:MARCHF9
gene id: 61622:MARCHF9
uniprot id: A0A2K6Q954
names: Subcellular Location Annotation
messages: Membrane

61622:PNMA2
gene id: 61622:PNMA2
uniprot id: A0A2K6NKS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNMA family.
messages: nucleolus

61622:GLE1
gene id: 61622:GLE1
uniprot id: A0A2K6Q3S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
messages: nuclear pore complex

61622:KRT20
gene id: 61622:KRT20
uniprot id: A0A2K6RU36
names: Similarity
messages: Belongs to the intermediate filament family.

61622:MYH1
gene id: 61622:MYH1
uniprot id: A0A2K6PL19
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:PSMC5
gene id: 61622:PSMC5
uniprot id: A0A2K6RIQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

61622:POLR3C
gene id: 61622:POLR3C
uniprot id: A0A2K6QV18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

61622:MAS1
gene id: 61622:MAS1
uniprot id: A0A2K6NR71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

61622:NIBAN1
gene id: 61622:NIBAN1
uniprot id: A0A2K6PL74
names: Similarity
messages: Belongs to the Niban family.

61622:LOC104671878
gene id: 61622:LOC104671878
uniprot id: A0A2K6NXG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

61622:IL21
gene id: 61622:IL21
uniprot id: A0A2K6NA36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

61622:SLCO1B1
gene id: 61622:SLCO1B1
uniprot id: A0A2K6QNX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

61622:CSTF3
gene id: 61622:CSTF3
uniprot id: A0A2K6RHG3
names: Subcellular Location Annotation
messages: Nucleus

61622:GRPEL1
gene id: 61622:GRPEL1
uniprot id: A0A2K6NEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

61622:SPPL3
gene id: 61622:SPPL3
uniprot id: A0A2K6PZU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

61622:VPS26B
gene id: 61622:VPS26B
uniprot id: A0A2K6QXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS26 family.
messages: Endosome

61622:COPS4
gene id: 61622:COPS4
uniprot id: A0A2K6PW42
uniprot id: A0A2K6PW52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

61622:GABRA6
gene id: 61622:GABRA6
uniprot id: A0A2K6PBN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:SLC2A7
gene id: 61622:SLC2A7
uniprot id: A0A2K6QDP9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:ISOC1
gene id: 61622:ISOC1
uniprot id: A0A2K6RTQ5
names: Similarity
messages: Belongs to the isochorismatase family.

61622:CAPN5
gene id: 61622:CAPN5
uniprot id: A0A2K6QZI1
names: Similarity
messages: Belongs to the peptidase C2 family.

61622:SELL
gene id: 61622:SELL
uniprot id: A0A2K6PEI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the selectin/LECAM family.
messages: Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
messages: Cell membrane
messages: Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:NUF2
gene id: 61622:NUF2
uniprot id: A0A2K6P491
names: Similarity
messages: Belongs to the NUF2 family.

61622:SLCO4C1
gene id: 61622:SLCO4C1
uniprot id: A0A2K6QB18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

61622:HOXA1
gene id: 61622:HOXA1
uniprot id: A0A2K6RD38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

61622:RRP36
gene id: 61622:RRP36
uniprot id: A0A2K6QZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

61622:LMBR1L
gene id: 61622:LMBR1L
uniprot id: A0A2K6RLK7
names: Similarity
messages: Belongs to the LIMR family.

61622:SLC25A40
gene id: 61622:SLC25A40
uniprot id: A0A2K6R2H1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

61622:LYRM9
gene id: 61622:LYRM9
uniprot id: A0A2K6PMM9
names: Similarity
messages: Belongs to the complex I LYR family. LYRM9 subfamily.

61622:ZSCAN21
gene id: 61622:ZSCAN21
uniprot id: A0A2K6QAX0
names: Subcellular Location Annotation
messages: Nucleus

61622:CACNG5
gene id: 61622:CACNG5
uniprot id: A0A2K6P8S9
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

61622:COPS6
gene id: 61622:COPS6
uniprot id: A0A2K6Q5T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

61622:TGFB3
gene id: 61622:TGFB3
uniprot id: A0A2K6NAM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.
messages: extracellular matrix

61622:NPM2
gene id: 61622:NPM2
uniprot id: A0A2K6RLI7
uniprot id: A0A2K6RLK6
names: Similarity
messages: Belongs to the nucleoplasmin family.

61622:GREM2
gene id: 61622:GREM2
uniprot id: A0A2K6NH78
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:PTTG1
gene id: 61622:PTTG1
uniprot id: A0A2K6RP53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

61622:BUD31
gene id: 61622:BUD31
uniprot id: A0A2K6QA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

61622:NRN1L
gene id: 61622:NRN1L
uniprot id: A0A2K6NAM1
names: Similarity
messages: Belongs to the neuritin family.

61622:PSMC1
gene id: 61622:PSMC1
uniprot id: A0A2K6NCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

61622:GGA1
gene id: 61622:GGA1
uniprot id: A0A2K6NKM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

61622:NTRK2
gene id: 61622:NTRK2
uniprot id: A0A2K6QVF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Cell membrane
messages: Membrane

61622:NANOS2
gene id: 61622:NANOS2
uniprot id: A0A2K6NHJ6
names: Similarity
messages: Belongs to the nanos family.

61622:MAP2K1
gene id: 61622:MAP2K1
uniprot id: A0A2K6PWS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LOC104663570
gene id: 61622:LOC104663570
uniprot id: A0A2K6NQ10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CDH8
gene id: 61622:CDH8
uniprot id: A0A2K6Q0T0
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:ACTR1A
gene id: 61622:ACTR1A
uniprot id: A0A2K6QRM1
names: Similarity
messages: Belongs to the actin family.

61622:SAG
gene id: 61622:SAG
uniprot id: A0A2K6NDH8
names: Similarity
messages: Belongs to the arrestin family.

61622:TBK1
gene id: 61622:TBK1
uniprot id: A0A2K6RG10
names: Subcellular Location Annotation
messages: Cytoplasm

61622:TRMT2B
gene id: 61622:TRMT2B
uniprot id: A0A2K6PCL3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TACC3
gene id: 61622:TACC3
uniprot id: A0A2K6QPY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: centrosome

61622:MAPK1IP1L
gene id: 61622:MAPK1IP1L
uniprot id: A0A2K6QUA8
names: Similarity
messages: Belongs to the MISS family.

61622:LOC104662043
gene id: 61622:LOC104662043
uniprot id: A0A2K6NCQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

61622:SUGCT
gene id: 61622:SUGCT
uniprot id: A0A2K6PPZ7
uniprot id: A0A2K6PQ06
names: Similarity
messages: Belongs to the CoA-transferase III family.

61622:NCBP2
gene id: 61622:NCBP2
uniprot id: A0A2K6PJT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

61622:UXS1
gene id: 61622:UXS1
uniprot id: A0A2K6PQX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

61622:ORMDL2
gene id: 61622:ORMDL2
uniprot id: A0A2K6QTF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

61622:DEUP1
gene id: 61622:DEUP1
uniprot id: A0A2K6NH22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP63 family.
messages: Cytoplasm

61622:IRF5
gene id: 61622:IRF5
uniprot id: A0A2K6P503
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:CXCL10
gene id: 61622:CXCL10
uniprot id: A0A2K6NFW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:GPR65
gene id: 61622:GPR65
uniprot id: A0A2K6NFK1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:CCS
gene id: 61622:CCS
uniprot id: A0A2K6QL98
names: Similarity
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

61622:HOMEZ
gene id: 61622:HOMEZ
uniprot id: A0A2K6RNM8
names: Subcellular Location Annotation
messages: Nucleus

61622:ADH5
gene id: 61622:ADH5
uniprot id: A0A2K6NCG6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

61622:MLN
gene id: 61622:MLN
uniprot id: A0A2K6NRN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
messages: Secreted

61622:CHRNA10
gene id: 61622:CHRNA10
uniprot id: A0A2K6RGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:LOC104682176
gene id: 61622:LOC104682176
uniprot id: A0A2K6N840
names: Similarity
messages: Belongs to the ATG8 family.

61622:FXR2
gene id: 61622:FXR2
uniprot id: A0A2K6Q3A1
names: Similarity
messages: Belongs to the FMR1 family.

61622:LONP2
gene id: 61622:LONP2
uniprot id: A0A2K6NRP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
messages: Belongs to the peptidase S16 family.
messages: Interacts with PEX5. Interacts with TYSND1.
messages: Peroxisome matrix

61622:AP2B1
gene id: 61622:AP2B1
uniprot id: A0A2K6P5Q2
uniprot id: A0A2K6P5R3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:ALG11
gene id: 61622:ALG11
uniprot id: A0A2K6QNW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly.

61622:IL2RB
gene id: 61622:IL2RB
uniprot id: A0A2K6RLB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Cell membrane
messages: Membrane
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.

61622:ARL11
gene id: 61622:ARL11
uniprot id: A0A2K6N7H7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:VCL
gene id: 61622:VCL
uniprot id: A0A2K6PTY9
uniprot id: A0A2K6PU01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

61622:TRDMT1
gene id: 61622:TRDMT1
uniprot id: A0A2K6QLL2
uniprot id: A0A2K6QLM0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

61622:CCNF
gene id: 61622:CCNF
uniprot id: A0A2K6RR90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family.
messages: centriole
messages: perinuclear region

61622:UNG
gene id: 61622:UNG
uniprot id: A0A2K6R7W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Monomer. Interacts with FAM72A.
messages: Nucleus

61622:PRKCA
gene id: 61622:PRKCA
uniprot id: A0A2K6RMH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

61622:LAMTOR4
gene id: 61622:LAMTOR4
uniprot id: A0A2K6RVX8
names: Similarity
messages: Belongs to the LAMTOR4 family.

61622:SPI1
gene id: 61622:SPI1
uniprot id: A0A2K6RWA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

61622:CDC20B
gene id: 61622:CDC20B
uniprot id: A0A2K6QPR6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

61622:CHRNA7
gene id: 61622:CHRNA7
uniprot id: A0A2K6PTH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:DTD2
gene id: 61622:DTD2
uniprot id: A0A2K6PQQ3
names: Similarity
messages: Belongs to the DTD family.

61622:TBX3
gene id: 61622:TBX3
uniprot id: A0A2K6QKD3
uniprot id: A0A2K6QKE6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:ARPIN
gene id: 61622:ARPIN
uniprot id: A0A2K6RWU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Arpin family.
messages: lamellipodium

61622:SLC39A13
gene id: 61622:SLC39A13
uniprot id: A0A2K6QKU1
names: Subcellular Location Annotation
messages: Membrane

61622:KRT8
gene id: 61622:KRT8
uniprot id: A0A2K6P3S2
names: Similarity
messages: Belongs to the intermediate filament family.

61622:SIRT5
gene id: 61622:SIRT5
uniprot id: A0A2K6PGP2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

61622:EXOC7
gene id: 61622:EXOC7
uniprot id: A0A2K6NVU5
uniprot id: A0A2K6NVV2
uniprot id: A0A2K6NVV8
uniprot id: A0A2K6NVW1
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61622:DMRT2
gene id: 61622:DMRT2
uniprot id: A0A2K6NUI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:BRPF1
gene id: 61622:BRPF1
uniprot id: A0A2K6QWR5
uniprot id: A0A2K6QWV1
names: Subcellular Location Annotation
messages: Nucleus

61622:MAP1LC3A
gene id: 61622:MAP1LC3A
uniprot id: A0A2K6PII6
names: Similarity
messages: Belongs to the ATG8 family.

61622:LOC104674164
gene id: 61622:LOC104674164
uniprot id: A0A2K6N9M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:NEUROD1
gene id: 61622:NEUROD1
uniprot id: A0A2K6ND93
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:POMT2
gene id: 61622:POMT2
uniprot id: A0A2K6NTI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

61622:MC3R
gene id: 61622:MC3R
uniprot id: A0A2K6NAZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane

61622:VPS54
gene id: 61622:VPS54
uniprot id: A0A2K6Q7G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

61622:VPS53
gene id: 61622:VPS53
uniprot id: A0A2K6RIA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

61622:SOSTDC1
gene id: 61622:SOSTDC1
uniprot id: A0A2K6PY56
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GCM1
gene id: 61622:GCM1
uniprot id: A0A2K6PHZ4
names: Subcellular Location Annotation
messages: Nucleus

61622:NDUFA10
gene id: 61622:NDUFA10
uniprot id: A0A2K6PBM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

61622:IDH3G
gene id: 61622:IDH3G
uniprot id: A0A2K6RN47
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

61622:DDX6
gene id: 61622:DDX6
uniprot id: A0A2K6PJH2
names: Similarity
messages: Belongs to the DEAD box helicase family.

61622:LOC104667089
gene id: 61622:LOC104667089
uniprot id: A0A2K6NNL8
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

61622:HMX2
gene id: 61622:HMX2
uniprot id: A0A2K6QLW9
names: Subcellular Location Annotation
messages: Nucleus

61622:ASIC3
gene id: 61622:ASIC3
uniprot id: A0A2K6NDU9
uniprot id: A0A2K6NDV7
names: Subcellular Location Annotation
messages: Membrane

61622:KRT23
gene id: 61622:KRT23
uniprot id: A0A2K6PMP5
names: Similarity
messages: Belongs to the intermediate filament family.

61622:DNAJB14
gene id: 61622:DNAJB14
uniprot id: A0A2K6NBS0
names: Subcellular Location Annotation
messages: Membrane

61622:BIRC2
gene id: 61622:BIRC2
uniprot id: A0A2K6QTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

61622:GFRA3
gene id: 61622:GFRA3
uniprot id: A0A2K6REI5
names: Similarity
messages: Belongs to the GDNFR family.

61622:SYT16
gene id: 61622:SYT16
uniprot id: A0A2K6QJX1
names: Similarity
messages: Belongs to the synaptotagmin family.

61622:LOC104668251
gene id: 61622:LOC104668251
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:MAP3K9
gene id: 61622:MAP3K9
uniprot id: A0A2K6NLI8
uniprot id: A0A2K6NLJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

61622:NR4A1
gene id: 61622:NR4A1
uniprot id: A0A2K6NVT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: Cytoplasm
messages: Nucleus

61622:CD99
gene id: 61622:CD99
uniprot id: A0A2K6NM71
names: Similarity
messages: Belongs to the CD99 family.

61622:NIF3L1
gene id: 61622:NIF3L1
uniprot id: A0A2K6R9J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Cytoplasm
messages: Homodimer. Interacts with COPS2. Interacts with THOC7.
messages: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
messages: Nucleus

61622:PCSK1
gene id: 61622:PCSK1
uniprot id: A0A2K6PLP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

61622:GPR87
gene id: 61622:GPR87
uniprot id: A0A2K6PT52
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:PAF1
gene id: 61622:PAF1
uniprot id: A0A2K6NPP2
names: Similarity
messages: Belongs to the PAF1 family.

61622:SLC35F1
gene id: 61622:SLC35F1
uniprot id: A0A2K6NH61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

61622:DNTTIP1
gene id: 61622:DNTTIP1
uniprot id: A0A2K6P8G4
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104679440
gene id: 61622:LOC104679440
uniprot id: A0A2K6NQE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SLC2A4
gene id: 61622:SLC2A4
uniprot id: A0A2K6NPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

61622:LOC104682342
gene id: 61622:LOC104682342
uniprot id: A0A2K6NLI9
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:ZCCHC8
gene id: 61622:ZCCHC8
uniprot id: A0A2K6P6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZCCHC8 family.
messages: nucleoplasm

61622:LOC104667780
gene id: 61622:LOC104667780
uniprot id: A0A2K6RE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:POU2F3
gene id: 61622:POU2F3
uniprot id: A0A2K6RUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

61622:IMMT
gene id: 61622:IMMT
uniprot id: A0A2K6NN72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

61622:P4HA1
gene id: 61622:P4HA1
uniprot id: A0A2K6RLV4
uniprot id: A0A2K6RLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61622:SPATA20
gene id: 61622:SPATA20
uniprot id: A0A2K6R9M3
names: Function
names: Subcellular Location Annotation
messages: May play a role in fertility regulation.
messages: Secreted

61622:PGLYRP2
gene id: 61622:PGLYRP2
uniprot id: A0A2K6RCR4
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

61622:MFSD4A
gene id: 61622:MFSD4A
uniprot id: A0A2K6PNR7
names: Subcellular Location Annotation
messages: Membrane

61622:NCBP3
gene id: 61622:NCBP3
uniprot id: A0A2K6RJP2
uniprot id: A0A2K6RJR9
names: Similarity
messages: Belongs to the NCBP3 family.

61622:NEU3
gene id: 61622:NEU3
uniprot id: A0A2K6NYF1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61622:CUTC
gene id: 61622:CUTC
uniprot id: A0A2K6QV54
names: Similarity
messages: Belongs to the CutC family.

61622:CPA6
gene id: 61622:CPA6
uniprot id: A0A2K6NIV0
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:TMEM132E
gene id: 61622:TMEM132E
uniprot id: A0A2K6PH66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

61622:ZC3HAV1
gene id: 61622:ZC3HAV1
uniprot id: A0A2K6R9N7
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:PLTP
gene id: 61622:PLTP
uniprot id: A0A2K6R8R3
names: Similarity
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

61622:MTHFD1
gene id: 61622:MTHFD1
uniprot id: A0A2K6RTN9
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

61622:ARG1
gene id: 61622:ARG1
uniprot id: A0A2K6Q0I6
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

61622:ADAMTS6
gene id: 61622:ADAMTS6
uniprot id: A0A2K6PKK6
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:RPGRIP1
gene id: 61622:RPGRIP1
uniprot id: A0A2K6RIJ2
names: Similarity
messages: Belongs to the RPGRIP1 family.

61622:BMP2
gene id: 61622:BMP2
uniprot id: A0A2K6P4A3
names: Similarity
messages: Belongs to the TGF-beta family.

61622:LOC104675895
gene id: 61622:LOC104675895
uniprot id: A0A2K6N6W7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

61622:RASSF1
gene id: 61622:RASSF1
uniprot id: A0A2K6QFF2
names: Subcellular Location Annotation
messages: cytoskeleton

61622:ITGB3
gene id: 61622:ITGB3
uniprot id: A0A2K6Q2S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61622:GHRH
gene id: 61622:GHRH
uniprot id: A0A2K6R933
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

61622:USP1
gene id: 61622:USP1
uniprot id: A0A2K6NUZ2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:STXBP5
gene id: 61622:STXBP5
uniprot id: A0A2K6NLD9
uniprot id: A0A2K6NLE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61622:MMP12
gene id: 61622:MMP12
uniprot id: A0A2K6PQ43
names: Similarity
messages: Belongs to the peptidase M10A family.

61622:IDS
gene id: 61622:IDS
uniprot id: A0A2K6Q6K4
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:RAG2
gene id: 61622:RAG2
uniprot id: A0A2K6N9V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

61622:GRWD1
gene id: 61622:GRWD1
uniprot id: A0A2K6R2Y8
names: Subcellular Location Annotation
messages: Nucleus

61622:RNF10
gene id: 61622:RNF10
uniprot id: A0A2K6Q1P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF10 family.
messages: Cytoplasm

61622:PLIN3
gene id: 61622:PLIN3
uniprot id: A0A2K6RKV8
names: Similarity
messages: Belongs to the perilipin family.

61622:TM4SF19
gene id: 61622:TM4SF19
uniprot id: A0A2K6Q4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:GPR107
gene id: 61622:GPR107
uniprot id: A0A2K6RHW5
uniprot id: A0A2K6RHW6
names: Subcellular Location Annotation
messages: Membrane

61622:PPP1R2
gene id: 61622:PPP1R2
uniprot id: A0A2K6NVD3
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

61622:LOC104677995
gene id: 61622:LOC104677995
uniprot id: A0A2K6PKP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

61622:FAM110C
gene id: 61622:FAM110C
uniprot id: A0A2K6QVC1
names: Similarity
messages: Belongs to the FAM110 family.

61622:SMIM12
gene id: 61622:SMIM12
uniprot id: A0A2K6N8P8
names: Similarity
messages: Belongs to the SMIM12 family.

61622:KIF3A
gene id: 61622:KIF3A
uniprot id: A0A2K6PD50
uniprot id: A0A2K6PDB6
uniprot id: A0A2K6PDC0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:WWOX
gene id: 61622:WWOX
uniprot id: A0A2K6NGE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm

61622:DISP3
gene id: 61622:DISP3
uniprot id: A0A2K6R2C2
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104662927
gene id: 61622:LOC104662927
uniprot id: A0A2K6PUZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

61622:LIMK2
gene id: 61622:LIMK2
uniprot id: A0A2K6RLF2
uniprot id: A0A2K6RLI0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

61622:ARL5B
gene id: 61622:ARL5B
uniprot id: A0A2K6Q2H7
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:TNFRSF8
gene id: 61622:TNFRSF8
uniprot id: A0A2K6R1C2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RAB3GAP1
gene id: 61622:RAB3GAP1
uniprot id: A0A2K6PQX1
uniprot id: A0A2K6PQY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm

61622:SLC16A9
gene id: 61622:SLC16A9
uniprot id: A0A2K6PPZ3
names: Subcellular Location Annotation
messages: Membrane

61622:SLC22A5
gene id: 61622:SLC22A5
uniprot id: A0A2K6Q591
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

61622:PGLYRP3
gene id: 61622:PGLYRP3
uniprot id: A0A2K6NZW7
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

61622:NUDT6
gene id: 61622:NUDT6
uniprot id: A0A2K6PHH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Cytoplasm
messages: May contribute to the regulation of cell proliferation.
messages: Mitochondrion
messages: Monomer and homodimer.
messages: Nucleus

61622:SLC29A3
gene id: 61622:SLC29A3
uniprot id: A0A2K6NT45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

61622:RGS5
gene id: 61622:RGS5
uniprot id: A0A2K6NFB7
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

61622:CDH19
gene id: 61622:CDH19
uniprot id: A0A2K6RL41
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

61622:SLC25A38
gene id: 61622:SLC25A38
uniprot id: A0A2K6RT73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

61622:ZDHHC4
gene id: 61622:ZDHHC4
uniprot id: A0A2K6NC28
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:LOC104655986
gene id: 61622:LOC104655986
uniprot id: A0A2K6R5E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p22phox family.
messages: Cell membrane
messages: Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).
messages: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
messages: Membrane

61622:CEL
gene id: 61622:CEL
uniprot id: A0A2K6RK83
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

61622:IL36G
gene id: 61622:IL36G
uniprot id: A0A2K6R510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

61622:TMEM14A
gene id: 61622:TMEM14A
uniprot id: A0A2K6R5M6
names: Similarity
messages: Belongs to the TMEM14 family.

61622:CLIC2
gene id: 61622:CLIC2
uniprot id: A0A2K6RRZ0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:TMEM176B
gene id: 61622:TMEM176B
uniprot id: A0A2K6R8S1
names: Similarity
messages: Belongs to the TMEM176 family.

61622:NDUFB3
gene id: 61622:NDUFB3
uniprot id: A0A2K6R105
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

61622:EBPL
gene id: 61622:EBPL
uniprot id: A0A2K6RTA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:IP6K3
gene id: 61622:IP6K3
uniprot id: A0A2K6QQ55
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:LOC104673107
gene id: 61622:LOC104673107
uniprot id: A0A2K6NSU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ACADM
gene id: 61622:ACADM
uniprot id: A0A2K6PKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Mitochondrion matrix

61622:LOC104671630
gene id: 61622:LOC104671630
uniprot id: A0A2K6NA22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:MOK
gene id: 61622:MOK
uniprot id: A0A2K6RST0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TLE1
gene id: 61622:TLE1
uniprot id: A0A2K6NZD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

61622:MAN2C1
gene id: 61622:MAN2C1
uniprot id: A0A2K6RLZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

61622:PTK2B
gene id: 61622:PTK2B
uniprot id: A0A2K6RDP1
uniprot id: A0A2K6RDT1
names: Subcellular Location Annotation
messages: Cell membrane
messages: cell cortex
messages: focal adhesion

61622:MRPS10
gene id: 61622:MRPS10
uniprot id: A0A2K6NBR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

61622:RPL28
gene id: 61622:RPL28
uniprot id: A0A2K6NXG3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

61622:SLC9A4
gene id: 61622:SLC9A4
uniprot id: A0A2K6R8G1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

61622:MOCS3
gene id: 61622:MOCS3
uniprot id: A0A2K6NBN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

61622:PAPSS1
gene id: 61622:PAPSS1
uniprot id: A0A2K6R4C5
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

61622:GPBP1L1
gene id: 61622:GPBP1L1
uniprot id: A0A2K6NCW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

61622:AIDA
gene id: 61622:AIDA
uniprot id: A0A2K6PA30
names: Similarity
messages: Belongs to the AIDA family.

61622:PTAR1
gene id: 61622:PTAR1
uniprot id: A0A2K6QZ13
uniprot id: A0A2K6QZ46
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

61622:NPHS2
gene id: 61622:NPHS2
uniprot id: A0A2K6NMI2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

61622:PCK1
gene id: 61622:PCK1
uniprot id: A0A2K6QW49
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

61622:HINT1
gene id: 61622:HINT1
uniprot id: A0A2K6NPK6
names: Similarity
messages: Belongs to the HINT family.

61622:DPEP2
gene id: 61622:DPEP2
uniprot id: A0A2K6PI17
names: Subcellular Location Annotation
messages: Membrane

61622:SRSF1
gene id: 61622:SRSF1
uniprot id: A0A2K6R4Z5
names: Similarity
messages: Belongs to the splicing factor SR family.

61622:FOXB1
gene id: 61622:FOXB1
uniprot id: A0A2K6N8F4
names: Subcellular Location Annotation
messages: Nucleus

61622:CCR1
gene id: 61622:CCR1
uniprot id: A0A2K6P8B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:POLR2I
gene id: 61622:POLR2I
uniprot id: A0A2K6RD69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

61622:SNTB1
gene id: 61622:SNTB1
uniprot id: A0A2K6R0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: Cell junction
messages: cytoskeleton

61622:CASP14
gene id: 61622:CASP14
uniprot id: A0A2K6R5W4
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:EIPR1
gene id: 61622:EIPR1
uniprot id: A0A2K6Q6W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EIPR1 family.
messages: trans-Golgi network

61622:RTCA
gene id: 61622:RTCA
uniprot id: A0A2K6NPQ1
uniprot id: A0A2K6NPQ7
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

61622:VAX1
gene id: 61622:VAX1
uniprot id: A0A2K6QFT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

61622:NDUFS3
gene id: 61622:NDUFS3
uniprot id: A0A2K6PD09
names: Similarity
messages: Belongs to the complex I 30 kDa subunit family.

61622:BCAT1
gene id: 61622:BCAT1
uniprot id: A0A2K6R8Q7
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

61622:RTRAF
gene id: 61622:RTRAF
uniprot id: A0A2K6P7B2
names: Similarity
messages: Belongs to the RTRAF family.

61622:BANF2
gene id: 61622:BANF2
uniprot id: A0A2K6QFQ7
names: Subcellular Location Annotation
messages: Nucleus

61622:SOGA1
gene id: 61622:SOGA1
uniprot id: A0A2K6N993
names: Similarity
messages: Belongs to the SOGA family.

61622:CKMT2
gene id: 61622:CKMT2
uniprot id: A0A2K6NXJ4
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

61622:GCNT4
gene id: 61622:GCNT4
uniprot id: A0A2K6Q8I2
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61622:TUBB
gene id: 61622:TUBB
uniprot id: A0A2K6Q336
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

61622:NEU2
gene id: 61622:NEU2
uniprot id: A0A2K6Q5P1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

61622:NLGN3
gene id: 61622:NLGN3
uniprot id: A0A2K6P5Z1
uniprot id: A0A2K6P603
uniprot id: A0A2K6P621
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

61622:ACTR3B
gene id: 61622:ACTR3B
uniprot id: A0A2K6RSM7
names: Similarity
messages: Belongs to the actin family.

61622:SEC24A
gene id: 61622:SEC24A
uniprot id: A0A2K6RWZ6
uniprot id: A0A2K6RX01
uniprot id: A0A2K6RX03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

61622:ALDH1A3
gene id: 61622:ALDH1A3
uniprot id: A0A2K6P0M4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:SLCO3A1
gene id: 61622:SLCO3A1
uniprot id: A0A2K6RJ69
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104682148
gene id: 61622:LOC104682148
uniprot id: A0A2K6RIJ1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

61622:HNF1B
gene id: 61622:HNF1B
uniprot id: A0A2K6NQ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HNF1 homeobox family.
messages: Nucleus

61622:ZFHX2
gene id: 61622:ZFHX2
uniprot id: A0A2K6Q256
names: Subcellular Location Annotation
messages: Nucleus

61622:PRDX2
gene id: 61622:PRDX2
uniprot id: A0A2K6Q0K4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

61622:LOC104661975
gene id: 61622:LOC104661975
uniprot id: A0A2K6QME6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

61622:SLITRK3
gene id: 61622:SLITRK3
uniprot id: A0A2K6QE87
names: Similarity
messages: Belongs to the SLITRK family.

61622:GCLM
gene id: 61622:GCLM
uniprot id: A0A2K6REB2
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

61622:IYD
gene id: 61622:IYD
uniprot id: A0A2K6RRX4
uniprot id: A0A2K6RRY2
uniprot id: A0A2K6RS09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasmic vesicle membrane

61622:STARD6
gene id: 61622:STARD6
uniprot id: A0A2K6P0R6
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

61622:HMCES
gene id: 61622:HMCES
uniprot id: A0A2K6NAW0
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

61622:SIM1
gene id: 61622:SIM1
uniprot id: A0A2K6Q4Z3
names: Subcellular Location Annotation
messages: Nucleus

61622:HADHA
gene id: 61622:HADHA
uniprot id: A0A2K6PM13
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

61622:FXR1
gene id: 61622:FXR1
uniprot id: A0A2K6PXZ1
uniprot id: A0A2K6PXZ2
uniprot id: A0A2K6PY00
names: Similarity
messages: Belongs to the FMR1 family.

61622:CREM
gene id: 61622:CREM
uniprot id: A0A2K6P2F7
uniprot id: A0A2K6P2H0
names: Subcellular Location Annotation
messages: Nucleus

61622:TMC2
gene id: 61622:TMC2
uniprot id: A0A2K6NG79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:WDR83OS
gene id: 61622:WDR83OS
uniprot id: A0A2K6Q285
names: Similarity
messages: Belongs to the Asterix family.

61622:MRPL17
gene id: 61622:MRPL17
uniprot id: A0A2K6PIH1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

61622:ATP1A2
gene id: 61622:ATP1A2
uniprot id: A0A2K6PQU8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:TNF
gene id: 61622:TNF
uniprot id: A0A2K6NLU3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.
messages: Homotrimer. Interacts with SPPL2B.
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.

61622:TSHR
gene id: 61622:TSHR
uniprot id: A0A2K6NYG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

61622:LSM2
gene id: 61622:LSM2
uniprot id: A0A2K6P670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

61622:COG3
gene id: 61622:COG3
uniprot id: A0A2K6NFW4
names: Function
names: Similarity
messages: Belongs to the COG3 family.
messages: Involved in ER-Golgi transport.

61622:GPR15
gene id: 61622:GPR15
uniprot id: A0A2K6NGG8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:XRCC5
gene id: 61622:XRCC5
uniprot id: A0A2K6PGS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase.

61622:ELP3
gene id: 61622:ELP3
uniprot id: A0A2K6Q3H6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

61622:DPY30
gene id: 61622:DPY30
uniprot id: A0A2K6RH52
names: Similarity
messages: Belongs to the dpy-30 family.

61622:EXOC5
gene id: 61622:EXOC5
uniprot id: A0A2K6QEE9
names: Function
names: Similarity
messages: Belongs to the SEC10 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

61622:RIPPLY2
gene id: 61622:RIPPLY2
uniprot id: A0A2K6N6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

61622:NDUFV2
gene id: 61622:NDUFV2
uniprot id: A0A2K6R0F2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

61622:LOC104677385
gene id: 61622:LOC104677385
uniprot id: A0A2K6P8G3
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

61622:PROP1
gene id: 61622:PROP1
uniprot id: A0A2K6QCQ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.

61622:EGR1
gene id: 61622:EGR1
uniprot id: A0A2K6RNT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

61622:SPEM1
gene id: 61622:SPEM1
uniprot id: A0A2K6QGV8
names: Subcellular Location Annotation
messages: Membrane

61622:CSTA
gene id: 61622:CSTA
uniprot id: A0A2K6RAC8
names: Similarity
messages: Belongs to the cystatin family.

61622:PAQR4
gene id: 61622:PAQR4
uniprot id: A0A2K6R5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:HTRA3
gene id: 61622:HTRA3
uniprot id: A0A2K6RJ17
uniprot id: A0A2K6RJ23
names: Similarity
messages: Belongs to the peptidase S1C family.

61622:MTERF1
gene id: 61622:MTERF1
uniprot id: A0A2K6PC18
names: Similarity
messages: Belongs to the mTERF family.

61622:ABI1
gene id: 61622:ABI1
uniprot id: A0A2K6NYW6
uniprot id: A0A2K6NYW8
uniprot id: A0A2K6NYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

61622:LIPT2
gene id: 61622:LIPT2
uniprot id: A0A2K6RSE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

61622:E2F7
gene id: 61622:E2F7
uniprot id: A0A2K6PFQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:DTNBP1
gene id: 61622:DTNBP1
uniprot id: A0A2K6PFL4
names: Similarity
messages: Belongs to the dysbindin family.

61622:CCNYL1
gene id: 61622:CCNYL1
uniprot id: A0A2K6QN69
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

61622:MAT2B
gene id: 61622:MAT2B
uniprot id: A0A2K6NAP0
uniprot id: A0A2K6NAR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

61622:IGFBP3
gene id: 61622:IGFBP3
uniprot id: A0A2K6N8Z8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:LIX1L
gene id: 61622:LIX1L
uniprot id: A0A2K6RIN5
names: Similarity
messages: Belongs to the LIX1 family.

61622:FGF8
gene id: 61622:FGF8
uniprot id: A0A2K6QNY7
uniprot id: A0A2K6QP25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

61622:LOC104667556
gene id: 61622:LOC104667556
uniprot id: A0A2K6NKQ6
names: Similarity
messages: Belongs to the MORF4 family-associated protein family.

61622:COQ10B
gene id: 61622:COQ10B
uniprot id: A0A2K6R1U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

61622:TFEC
gene id: 61622:TFEC
uniprot id: A0A2K6RDG9
uniprot id: A0A2K6RDH8
uniprot id: A0A2K6RDM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

61622:CLPTM1
gene id: 61622:CLPTM1
uniprot id: A0A2K6P8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

61622:GPD1
gene id: 61622:GPD1
uniprot id: A0A2K6RTL8
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

61622:DRAXIN
gene id: 61622:DRAXIN
uniprot id: A0A2K6QM47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
messages: Interacts with LRP6.
messages: Secreted

61622:CLSPN
gene id: 61622:CLSPN
uniprot id: A0A2K6P9I3
names: Subcellular Location Annotation
messages: Nucleus

61622:TBCD
gene id: 61622:TBCD
uniprot id: A0A2K6PMP7
names: Similarity
messages: Belongs to the TBCD family.

61622:PRDM1
gene id: 61622:PRDM1
uniprot id: A0A2K6PMY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

61622:VPS16
gene id: 61622:VPS16
uniprot id: A0A2K6RA00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

61622:KCNS3
gene id: 61622:KCNS3
uniprot id: A0A2K6NBH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SERPINF2
gene id: 61622:SERPINF2
uniprot id: A0A2K6NE77
names: Similarity
messages: Belongs to the serpin family.

61622:ATP4A
gene id: 61622:ATP4A
uniprot id: A0A2K6RIT1
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Membrane

61622:RPS3A
gene id: 61622:RPS3A
uniprot id: A0A2K6R5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus

61622:SYT1
gene id: 61622:SYT1
uniprot id: A0A2K6P3M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

61622:ARPC1A
gene id: 61622:ARPC1A
uniprot id: A0A2K6PWQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

61622:LOC104660868
gene id: 61622:LOC104660868
uniprot id: A0A2K6PQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

61622:MTM1
gene id: 61622:MTM1
uniprot id: A0A2K6QQH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

61622:BLK
gene id: 61622:BLK
uniprot id: A0A2K6QZ25
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:SMO
gene id: 61622:SMO
uniprot id: A0A2K6P5M1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SLC12A5
gene id: 61622:SLC12A5
uniprot id: A0A2K6PJZ3
uniprot id: A0A2K6R7Q2
uniprot id: A0A2K6R7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Belongs to the peptidase M10A family.
messages: Membrane
messages: extracellular matrix

61622:S1PR1
gene id: 61622:S1PR1
uniprot id: A0A2K6NB97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:CDC37L1
gene id: 61622:CDC37L1
uniprot id: A0A2K6Q9A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

61622:LHX2
gene id: 61622:LHX2
uniprot id: A0A2K6QDH4
names: Subcellular Location Annotation
messages: Nucleus

61622:NRN1
gene id: 61622:NRN1
uniprot id: A0A2K6P1T2
names: Similarity
messages: Belongs to the neuritin family.

61622:GMPPA
gene id: 61622:GMPPA
uniprot id: A0A2K6QQ96
uniprot id: A0A2K6QQC0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

61622:FABP5
gene id: 61622:FABP5
uniprot id: A0A2K6Q2Z3
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:PLIN2
gene id: 61622:PLIN2
uniprot id: A0A2K6QQF9
names: Similarity
messages: Belongs to the perilipin family.

61622:TMEM182
gene id: 61622:TMEM182
uniprot id: A0A2K6N7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM182 family.
messages: Cell membrane
messages: Membrane

61622:NT5C3A
gene id: 61622:NT5C3A
uniprot id: A0A2K6P9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

61622:SEMA6A
gene id: 61622:SEMA6A
uniprot id: A0A2K6RU85
uniprot id: A0A2K6RU86
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SLC6A13
gene id: 61622:SLC6A13
uniprot id: A0A2K6NCP6
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Membrane

61622:KIF26A
gene id: 61622:KIF26A
uniprot id: A0A2K6RGN2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:NTN4
gene id: 61622:NTN4
uniprot id: A0A2K6RR20
uniprot id: A0A2K6RR54
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:C15H11orf49
gene id: 61622:C15H11orf49
uniprot id: A0A2K6RWR3
uniprot id: A0A2K6RWR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

61622:PROX1
gene id: 61622:PROX1
uniprot id: A0A2K6PIK5
uniprot id: A0A2K6PIK7
names: Subcellular Location Annotation
messages: Nucleus

61622:RPS8
gene id: 61622:RPS8
uniprot id: A0A2K6R8Z7
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

61622:EWSR1
gene id: 61622:EWSR1
uniprot id: A0A2K6QXH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

61622:SIX6
gene id: 61622:SIX6
uniprot id: A0A2K6RVI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

61622:DCLRE1A
gene id: 61622:DCLRE1A
uniprot id: A0A2K6RK71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

61622:NDUFA8
gene id: 61622:NDUFA8
uniprot id: A0A2K6R2K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

61622:DHODH
gene id: 61622:DHODH
uniprot id: A0A2K6REV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

61622:CALB1
gene id: 61622:CALB1
uniprot id: A0A2K6PXM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
messages: Interacts with RANBP9.

61622:HMGCS2
gene id: 61622:HMGCS2
uniprot id: A0A2K6PX20
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

61622:SRF
gene id: 61622:SRF
uniprot id: A0A2K6PW62
names: Subcellular Location Annotation
messages: Nucleus

61622:CD38
gene id: 61622:CD38
uniprot id: A0A2K6P8H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

61622:POLR2C
gene id: 61622:POLR2C
uniprot id: A0A2K6RXK9
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

61622:MTX3
gene id: 61622:MTX3
uniprot id: A0A2K6NNL0
uniprot id: A0A2K6NNL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:VIRMA
gene id: 61622:VIRMA
uniprot id: A0A2K6QFK9
names: Similarity
messages: Belongs to the vir family.

61622:RIPK2
gene id: 61622:RIPK2
uniprot id: A0A2K6RXI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.

61622:GCDH
gene id: 61622:GCDH
uniprot id: A0A2K6RQW5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

61622:RBM15
gene id: 61622:RBM15
uniprot id: A0A2K6RW02
uniprot id: A0A2K6RW04
names: Similarity
messages: Belongs to the RRM Spen family.

61622:ELP1
gene id: 61622:ELP1
uniprot id: A0A2K6RKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

61622:PEAR1
gene id: 61622:PEAR1
uniprot id: A0A2K6PYZ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SCOC
gene id: 61622:SCOC
uniprot id: A0A2K6QL86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

61622:NOC4L
gene id: 61622:NOC4L
uniprot id: A0A2K6PPV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Nucleus membrane

61622:HOXC12
gene id: 61622:HOXC12
uniprot id: A0A2K6QRF6
names: Subcellular Location Annotation
messages: Nucleus

61622:GTF2A1L
gene id: 61622:GTF2A1L
uniprot id: A0A2K6QU86
uniprot id: A0A2K6QU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

61622:LOC104664204
gene id: 61622:LOC104664204
uniprot id: A0A2K6Q243
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:TRMT1L
gene id: 61622:TRMT1L
uniprot id: A0A2K6PHP1
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

61622:UGT3A2
gene id: 61622:UGT3A2
uniprot id: A0A2K6P7X5
uniprot id: A0A2K6P7X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:KIAA2013
gene id: 61622:KIAA2013
uniprot id: A0A2K6QIX5
names: Subcellular Location Annotation
messages: Membrane

61622:CFAP43
gene id: 61622:CFAP43
uniprot id: A0A2K6PHB5
names: Similarity
messages: Belongs to the CFAP43 family.

61622:SPATA18
gene id: 61622:SPATA18
uniprot id: A0A2K6N6X8
uniprot id: A0A2K6N6X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIEAP family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion outer membrane

61622:DHX15
gene id: 61622:DHX15
uniprot id: A0A2K6QPY4
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

61622:SYNDIG1L
gene id: 61622:SYNDIG1L
uniprot id: A0A2K6R2G9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:RPS13
gene id: 61622:RPS13
uniprot id: A0A2K6QGL4
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

61622:C21H18orf32
gene id: 61622:C21H18orf32
uniprot id: A0A2K6R6Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPF0729 family.
messages: Interacts with DERL1 and AMFR.
messages: May activate the NF-kappa-B signaling pathway.

61622:TUBGCP3
gene id: 61622:TUBGCP3
uniprot id: A0A2K6RDA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

61622:ARID1A
gene id: 61622:ARID1A
uniprot id: A0A2K6QA56
names: Subcellular Location Annotation
messages: Nucleus

61622:RPAP2
gene id: 61622:RPAP2
uniprot id: A0A2K6PMX9
uniprot id: A0A2K6PN34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.

61622:KIF9
gene id: 61622:KIF9
uniprot id: A0A2K6PUV6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:PLCD1
gene id: 61622:PLCD1
uniprot id: A0A2K6PQT3
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

61622:RPL13A
gene id: 61622:RPL13A
uniprot id: A0A2K6RE78
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

61622:SF3B4
gene id: 61622:SF3B4
uniprot id: A0A2K6P026
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

61622:ATP6V1C1
gene id: 61622:ATP6V1C1
uniprot id: A0A2K6Q7C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

61622:LOC104680184
gene id: 61622:LOC104680184
uniprot id: A0A2K6NSI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

61622:ZNF274
gene id: 61622:ZNF274
uniprot id: A0A2K6RR07
names: Subcellular Location Annotation
messages: Nucleus

61622:ITGB2
gene id: 61622:ITGB2
uniprot id: A0A2K6RN16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61622:BORCS7
gene id: 61622:BORCS7
uniprot id: A0A2K6P9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORCS7 family.
messages: Membrane

61622:TRMO
gene id: 61622:TRMO
uniprot id: A0A2K6PIL3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

61622:FANCC
gene id: 61622:FANCC
uniprot id: A0A2K6RGC9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.
messages: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
messages: Nucleus

61622:CFAP97D1
gene id: 61622:CFAP97D1
uniprot id: A0A2K6PLJ7
names: Similarity
messages: Belongs to the CFAP97 family.

61622:AP4E1
gene id: 61622:AP4E1
uniprot id: A0A2K6R0A2
names: Function
names: Similarity
names: Subunit
messages: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

61622:FRZB
gene id: 61622:FRZB
uniprot id: A0A2K6RVE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

61622:YIPF3
gene id: 61622:YIPF3
uniprot id: A0A2K6Q4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

61622:UCP2
gene id: 61622:UCP2
uniprot id: A0A2K6NRS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:BCAS2
gene id: 61622:BCAS2
uniprot id: A0A2K6RN21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

61622:NUDT12
gene id: 61622:NUDT12
uniprot id: A0A2K6R147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

61622:LOC104654088
gene id: 61622:LOC104654088
uniprot id: A0A2K6QRV3
names: Similarity
messages: Belongs to the CLCR family.

61622:MTMR11
gene id: 61622:MTMR11
uniprot id: A0A2K6PD81
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

61622:LOC104653690
gene id: 61622:LOC104653690
uniprot id: A0A2K6NC63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:PLD5
gene id: 61622:PLD5
uniprot id: A0A2K6PQG4
uniprot id: A0A2K6PQH6
names: Similarity
messages: Belongs to the phospholipase D family.

61622:CRBN
gene id: 61622:CRBN
uniprot id: A0A2K6QT48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

61622:CDC6
gene id: 61622:CDC6
uniprot id: A0A2K6R0U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
messages: Nucleus

61622:GUCY1B1
gene id: 61622:GUCY1B1
uniprot id: A0A2K6QJ78
uniprot id: A0A2K6QJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Cytoplasm

61622:LOC104682323
gene id: 61622:LOC104682323
uniprot id: A0A2K6QL21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

61622:PPIL2
gene id: 61622:PPIL2
uniprot id: A0A2K6QNH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

61622:LRRFIP2
gene id: 61622:LRRFIP2
uniprot id: A0A2K6PLC5
names: Similarity
messages: Belongs to the LRRFIP family.

61622:LYG2
gene id: 61622:LYG2
uniprot id: A0A2K6PVC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 23 family.

61622:CDK16
gene id: 61622:CDK16
uniprot id: A0A2K6R576
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:IDI2
gene id: 61622:IDI2
uniprot id: A0A2K6NKN0
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

61622:SLC9A9
gene id: 61622:SLC9A9
uniprot id: A0A2K6QG30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Endosome membrane
messages: Membrane

61622:CTSA
gene id: 61622:CTSA
uniprot id: A0A2K6Q8H0
names: Similarity
messages: Belongs to the peptidase S10 family.

61622:YIPF6
gene id: 61622:YIPF6
uniprot id: A0A2K6QJD1
uniprot id: A0A2K6QJF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

61622:GSDME
gene id: 61622:GSDME
uniprot id: A0A2K6QID1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61622:FLT3
gene id: 61622:FLT3
uniprot id: A0A2K6PJQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

61622:LOC104681099
gene id: 61622:LOC104681099
uniprot id: A0A2K6N7C4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TRNAU1AP
gene id: 61622:TRNAU1AP
uniprot id: A0A2K6NYM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

61622:AGMAT
gene id: 61622:AGMAT
uniprot id: A0A2K6PMG3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

61622:MRPL13
gene id: 61622:MRPL13
uniprot id: A0A2K6RPV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

61622:HMGB3
gene id: 61622:HMGB3
uniprot id: A0A2K6NHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

61622:RPS5
gene id: 61622:RPS5
uniprot id: A0A2K6QCM4
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

61622:IRF6
gene id: 61622:IRF6
uniprot id: A0A2K6PPD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:ZFHX4
gene id: 61622:ZFHX4
uniprot id: A0A2K6PCE4
names: Subcellular Location Annotation
messages: Nucleus

61622:SERINC3
gene id: 61622:SERINC3
uniprot id: A0A2K6NEM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

61622:HSP90AB1
gene id: 61622:HSP90AB1
uniprot id: A0A2K6RR95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

61622:CLCN3
gene id: 61622:CLCN3
uniprot id: A0A2K6RGD0
uniprot id: A0A2K6RGF0
uniprot id: A0A2K6RGI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61622:RBBP5
gene id: 61622:RBBP5
uniprot id: A0A2K6RT17
names: Subcellular Location Annotation
messages: Nucleus

61622:RPL36
gene id: 61622:RPL36
uniprot id: A0A2K6NTS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

61622:LOC104675028
gene id: 61622:LOC104675028
uniprot id: A0A2K6QTU3
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

61622:BROX
gene id: 61622:BROX
uniprot id: A0A2K6R6N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BROX family.
messages: Membrane

61622:LOC104682016
gene id: 61622:LOC104682016
uniprot id: A0A2K6NA85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

61622:ATP1B2
gene id: 61622:ATP1B2
uniprot id: A0A2K6RGG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

61622:MTR
gene id: 61622:MTR
uniprot id: A0A2K6NMY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

61622:CPSF3
gene id: 61622:CPSF3
uniprot id: A0A2K6PSV5
names: Subcellular Location Annotation
messages: Nucleus

61622:EP300
gene id: 61622:EP300
uniprot id: A0A2K6QGX0
names: Subcellular Location Annotation
messages: Cytoplasm

61622:SHFL
gene id: 61622:SHFL
uniprot id: A0A2K6Q8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHFL family.
messages: Nucleus
messages: P-body

61622:PARP1
gene id: 61622:PARP1
uniprot id: A0A2K6NZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

61622:SVOPL
gene id: 61622:SVOPL
uniprot id: A0A2K6QC65
names: Subcellular Location Annotation
messages: Membrane

61622:CFL1
gene id: 61622:CFL1
uniprot id: A0A2K6QKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

61622:SV2A
gene id: 61622:SV2A
uniprot id: A0A2K6P776
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

61622:LRRFIP1
gene id: 61622:LRRFIP1
uniprot id: A0A2K6NAC6
names: Similarity
messages: Belongs to the LRRFIP family.

61622:PRCP
gene id: 61622:PRCP
uniprot id: A0A2K6R925
names: Similarity
messages: Belongs to the peptidase S28 family.

61622:ZNRD1
gene id: 61622:ZNRD1
uniprot id: A0A2K6QK90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.
messages: nucleolus

61622:GDE1
gene id: 61622:GDE1
uniprot id: A0A2K6QVB5
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:GATC
gene id: 61622:GATC
uniprot id: A0A2K6RCV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

61622:IRAK4
gene id: 61622:IRAK4
uniprot id: A0A2K6QAA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Cytoplasm
messages: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.

61622:TGS1
gene id: 61622:TGS1
uniprot id: A0A2K6Q180
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

61622:FAM160A2
gene id: 61622:FAM160A2
uniprot id: A0A2K6N7E1
names: Similarity
messages: Belongs to the FHIP family.

61622:MASP1
gene id: 61622:MASP1
uniprot id: A0A2K6Q3W9
uniprot id: A0A2K6Q3X5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:UFM1
gene id: 61622:UFM1
uniprot id: A0A2K6P8G3
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

61622:SELENOO
gene id: 61622:SELENOO
uniprot id: A0A2K6QH27
names: Similarity
messages: Belongs to the SELO family.

61622:TTC25
gene id: 61622:TTC25
uniprot id: A0A2K6RIY0
names: Subcellular Location Annotation
messages: cilium axoneme

61622:PARP10
gene id: 61622:PARP10
uniprot id: A0A2K6QPL9
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:IGF2BP1
gene id: 61622:IGF2BP1
uniprot id: A0A2K6QSR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule
messages: filopodium
messages: growth cone
messages: lamellipodium
messages: perinuclear region

61622:ASB8
gene id: 61622:ASB8
uniprot id: A0A2K6PST1
names: Function
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

61622:NUTF2
gene id: 61622:NUTF2
uniprot id: A0A2K6QKH6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

61622:SPTB
gene id: 61622:SPTB
uniprot id: A0A2K6NFS7
names: Similarity
messages: Belongs to the spectrin family.

61622:ARMT1
gene id: 61622:ARMT1
uniprot id: A0A2K6NCE5
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

61622:SCFD1
gene id: 61622:SCFD1
uniprot id: A0A2K6PNH2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61622:MYO3B
gene id: 61622:MYO3B
uniprot id: A0A2K6RAE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: In the C-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: cytoskeleton

61622:LOC104682240
gene id: 61622:LOC104682240
uniprot id: A0A2K6RXT7
names: Similarity
messages: Belongs to the serpin family.

61622:CA10
gene id: 61622:CA10
uniprot id: A0A2K6Q0Z2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

61622:TMCC1
gene id: 61622:TMCC1
uniprot id: A0A2K6NS73
names: Similarity
messages: Belongs to the TEX28 family.

61622:POSTN
gene id: 61622:POSTN
uniprot id: A0A2K6QGI3
uniprot id: A0A2K6QGI9
uniprot id: A0A2K6QGJ2
uniprot id: A0A2K6QGJ3
uniprot id: A0A2K6QGL2
names: Subcellular Location Annotation
messages: extracellular matrix

61622:LOC104663505
gene id: 61622:LOC104663505
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:PRORP
gene id: 61622:PRORP
uniprot id: A0A2K6R3A5
names: Similarity
messages: Belongs to the PPR family. P subfamily.

61622:MS4A2
gene id: 61622:MS4A2
uniprot id: A0A2K6QZK0
names: Similarity
messages: Belongs to the MS4A family.

61622:DDOST
gene id: 61622:DDOST
uniprot id: A0A2K6Q015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

61622:TADA2B
gene id: 61622:TADA2B
uniprot id: A0A2K6NXW1
names: Subcellular Location Annotation
messages: Nucleus

61622:TMPRSS11D
gene id: 61622:TMPRSS11D
uniprot id: A0A2K6PIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61622:LASP1
gene id: 61622:LASP1
uniprot id: A0A2K6R9B5
uniprot id: A0A2K6R9F2
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

61622:TRH
gene id: 61622:TRH
uniprot id: A0A2K6P507
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRH family.
messages: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
messages: Secreted

61622:C1D
gene id: 61622:C1D
uniprot id: A0A2K6NY16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Nucleus
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

61622:CRYAB
gene id: 61622:CRYAB
uniprot id: A0A2K6NWL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Nucleus

61622:PYCR2
gene id: 61622:PYCR2
uniprot id: A0A2K6RNK9
uniprot id: A0A2K6RNL1
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61622:KIF5B
gene id: 61622:KIF5B
uniprot id: A0A2K6NFZ2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:WNT1
gene id: 61622:WNT1
uniprot id: A0A2K6NBC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:MFAP2
gene id: 61622:MFAP2
uniprot id: A0A2K6RXL3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MFAP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:DHDH
gene id: 61622:DHDH
uniprot id: A0A2K6RDF1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

61622:P2RX7
gene id: 61622:P2RX7
uniprot id: A0A2K6NC26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61622:ESS2
gene id: 61622:ESS2
uniprot id: A0A2K6NH30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

61622:MINDY1
gene id: 61622:MINDY1
uniprot id: A0A2K6QDK6
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

61622:ATF7IP2
gene id: 61622:ATF7IP2
uniprot id: A0A2K6QP21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

61622:DAO
gene id: 61622:DAO
uniprot id: A0A2K6NXX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

61622:FAM210A
gene id: 61622:FAM210A
uniprot id: A0A2K6QGL1
names: Similarity
messages: Belongs to the FAM210 family.

61622:NPRL3
gene id: 61622:NPRL3
uniprot id: A0A2K6QSK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome

61622:CNGA2
gene id: 61622:CNGA2
uniprot id: A0A2K6PFY7
names: Subcellular Location Annotation
messages: Membrane

61622:CROT
gene id: 61622:CROT
uniprot id: A0A2K6RJU3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

61622:THRAP3
gene id: 61622:THRAP3
uniprot id: A0A2K6NVH4
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

61622:FGF4
gene id: 61622:FGF4
uniprot id: A0A2K6NVF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

61622:CD200R1
gene id: 61622:CD200R1
uniprot id: A0A2K6QFV6
names: Similarity
messages: Belongs to the CD200R family.

61622:FUZ
gene id: 61622:FUZ
uniprot id: A0A2K6QGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

61622:IPO7
gene id: 61622:IPO7
uniprot id: A0A2K6PFC8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:AASS
gene id: 61622:AASS
uniprot id: A0A2K6QB68
uniprot id: A0A2K6QB75
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

61622:MTO1
gene id: 61622:MTO1
uniprot id: A0A2K6P547
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

61622:ZNF326
gene id: 61622:ZNF326
uniprot id: A0A2K6PHD0
names: Similarity
messages: Belongs to the AKAP95 family.

61622:ORMDL3
gene id: 61622:ORMDL3
uniprot id: A0A2K6P855
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Interacts with SPTLC1.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

61622:LOC104653583
gene id: 61622:LOC104653583
uniprot id: A0A2K6QVQ8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:SLC41A2
gene id: 61622:SLC41A2
uniprot id: A0A2K6NDR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

61622:SUMO1
gene id: 61622:SUMO1
uniprot id: A0A2K6Q379
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

61622:OSBPL6
gene id: 61622:OSBPL6
uniprot id: A0A2K6Q7X9
uniprot id: A0A2K6Q7Z8
names: Similarity
messages: Belongs to the OSBP family.

61622:MED7
gene id: 61622:MED7
uniprot id: A0A2K6NQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

61622:SLC18A3
gene id: 61622:SLC18A3
uniprot id: A0A2K6QFI6
names: Subcellular Location Annotation
messages: Membrane

61622:GAS6
gene id: 61622:GAS6
uniprot id: A0A2K6QVJ7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PSMB6
gene id: 61622:PSMB6
uniprot id: A0A2K6NS66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

61622:CHAF1B
gene id: 61622:CHAF1B
uniprot id: A0A2K6NSZ8
names: Subcellular Location Annotation
messages: Nucleus

61622:TMC3
gene id: 61622:TMC3
uniprot id: A0A2K6R6S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

61622:FMNL3
gene id: 61622:FMNL3
uniprot id: A0A2K6NJN9
uniprot id: A0A2K6NJR2
uniprot id: A0A2K6NJS5
names: Similarity
messages: Belongs to the formin homology family.

61622:SH3BP5L
gene id: 61622:SH3BP5L
uniprot id: A0A2K6RVG8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SH3BP5 family.
messages: Cytoplasm
messages: Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
messages: Interacts with GDP-bound and nucleotide-free forms of RAB11A.
messages: The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape.

61622:HSD17B12
gene id: 61622:HSD17B12
uniprot id: A0A2K6R6D3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:DHRS7B
gene id: 61622:DHRS7B
uniprot id: A0A2K6NLW2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:AVPR1A
gene id: 61622:AVPR1A
uniprot id: A0A2K6QML0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

61622:SLC25A16
gene id: 61622:SLC25A16
uniprot id: A0A2K6P1N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:CDH1
gene id: 61622:CDH1
uniprot id: A0A2K6R725
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
messages: Membrane
messages: trans-Golgi network

61622:MCOLN3
gene id: 61622:MCOLN3
uniprot id: A0A2K6QWW8
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

61622:ATG9A
gene id: 61622:ATG9A
uniprot id: A0A2K6N936
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

61622:ENTPD1
gene id: 61622:ENTPD1
uniprot id: A0A2K6PDE4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:EFNB1
gene id: 61622:EFNB1
uniprot id: A0A2K6PCK8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:AMPD3
gene id: 61622:AMPD3
uniprot id: A0A2K6QQ72
uniprot id: A0A2K6QQ80
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Homotetramer.

61622:SDR9C7
gene id: 61622:SDR9C7
uniprot id: A0A2K6PPM0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:YIPF2
gene id: 61622:YIPF2
uniprot id: A0A2K6NUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

61622:LOC104656671
gene id: 61622:LOC104656671
uniprot id: A0A2K6NZ76
uniprot id: A0A2K6NZC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

61622:ACER1
gene id: 61622:ACER1
uniprot id: A0A2K6NMG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

61622:RARB
gene id: 61622:RARB
uniprot id: A0A2K6QW41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:IRAK2
gene id: 61622:IRAK2
uniprot id: A0A2K6N8S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
messages: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
messages: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

61622:CCR5
gene id: 61622:CCR5
uniprot id: Q7JJ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4. Interacts with S100A4; this interaction stimulates T-lymphocyte chemotaxis.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:MRPL11
gene id: 61622:MRPL11
uniprot id: A0A2K6R1U4
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

61622:SELE
gene id: 61622:SELE
uniprot id: A0A2K6QSC7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selectin/LECAM family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:AGL
gene id: 61622:AGL
uniprot id: A0A2K6R025
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

61622:PSMD1
gene id: 61622:PSMD1
uniprot id: A0A2K6RSX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the proteasome subunit S1 family.
messages: Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

61622:KMT5C
gene id: 61622:KMT5C
uniprot id: A0A2K6QVI7
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104681051
gene id: 61622:LOC104681051
uniprot id: A0A2K6QID8
names: Function
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
messages: nucleoplasm

61622:POPDC3
gene id: 61622:POPDC3
uniprot id: A0A2K6NCD1
names: Similarity
messages: Belongs to the popeye family.

61622:EPB41
gene id: 61622:EPB41
uniprot id: A0A2K6RGV6
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex

61622:PTPA
gene id: 61622:PTPA
uniprot id: A0A2K6PW82
uniprot id: A0A2K6PW86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:CORO1C
gene id: 61622:CORO1C
uniprot id: A0A2K6NJ88
names: Similarity
messages: Belongs to the WD repeat coronin family.

61622:GPNMB
gene id: 61622:GPNMB
uniprot id: A0A2K6REY5
names: Similarity
messages: Belongs to the PMEL/NMB family.

61622:ASXL2
gene id: 61622:ASXL2
uniprot id: A0A2K6PX85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asx family.
messages: Nucleus

61622:RPS4Y1
gene id: 61622:RPS4Y1
uniprot id: A0A2K6NS30
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

61622:TAF1D
gene id: 61622:TAF1D
uniprot id: A0A2K6QB03
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

61622:LOC104668621
gene id: 61622:LOC104668621
uniprot id: A0A2K6R403
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:MARS2
gene id: 61622:MARS2
uniprot id: A0A2K6NFV5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:SERPINA1
gene id: 61622:SERPINA1
uniprot id: A0A2K6R326
names: Similarity
messages: Belongs to the serpin family.

61622:GDI2
gene id: 61622:GDI2
uniprot id: A0A2K6P708
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

61622:MRTO4
gene id: 61622:MRTO4
uniprot id: A0A2K6RD65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

61622:SHKBP1
gene id: 61622:SHKBP1
uniprot id: A0A2K6RNG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KCTD3 family.
messages: Cell membrane

61622:TNFRSF25
gene id: 61622:TNFRSF25
uniprot id: A0A2K6RBE5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GOLGA5
gene id: 61622:GOLGA5
uniprot id: A0A2K6P3W3
names: Function
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
messages: Membrane

61622:HSF1
gene id: 61622:HSF1
uniprot id: A0A2K6NA02
uniprot id: A0A2K6NA20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:TARS3
gene id: 61622:TARS3
uniprot id: A0A2K6P0X0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:EIF5A2
gene id: 61622:EIF5A2
uniprot id: A0A2K6R7R5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.
messages: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis.

61622:PPP2R2C
gene id: 61622:PPP2R2C
uniprot id: A0A2K6RUR2
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

61622:DMRT1
gene id: 61622:DMRT1
uniprot id: A0A2K6Q147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:L3MBTL3
gene id: 61622:L3MBTL3
uniprot id: A0A2K6PM69
uniprot id: A0A2K6PM87
names: Subcellular Location Annotation
messages: Nucleus

61622:TCTEX1D1
gene id: 61622:TCTEX1D1
uniprot id: A0A2K6QDD7
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:NUTM1
gene id: 61622:NUTM1
uniprot id: A0A2K6PGR9
uniprot id: A0A2K6PH03
names: Similarity
messages: Belongs to the NUT family.

61622:ATP6V0C
gene id: 61622:ATP6V0C
uniprot id: A0A2K6QMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

61622:GNPDA2
gene id: 61622:GNPDA2
uniprot id: A0A2K6RCG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

61622:HK3
gene id: 61622:HK3
uniprot id: A0A2K6QCB4
names: Similarity
messages: Belongs to the hexokinase family.

61622:PRKCG
gene id: 61622:PRKCG
uniprot id: A0A2K6PL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm
messages: Membrane

61622:PYCARD
gene id: 61622:PYCARD
uniprot id: A0A2K6RFU5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inflammasome

61622:GALP
gene id: 61622:GALP
uniprot id: A0A2K6PV20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
messages: Secreted

61622:MRPS25
gene id: 61622:MRPS25
uniprot id: A0A2K6PYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

61622:TNC
gene id: 61622:TNC
uniprot id: A0A2K6NME5
uniprot id: A0A2K6NME8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:LOC104663687
gene id: 61622:LOC104663687
uniprot id: A0A2K6PL26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

61622:SERPIND1
gene id: 61622:SERPIND1
uniprot id: A0A2K6R200
names: Similarity
messages: Belongs to the serpin family.

61622:GDF5
gene id: 61622:GDF5
uniprot id: A0A2K6NIS5
names: Similarity
messages: Belongs to the TGF-beta family.

61622:LOC104673722
gene id: 61622:LOC104673722
uniprot id: A0A2K6NBL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:HEATR5B
gene id: 61622:HEATR5B
uniprot id: A0A2K6NBS4
names: Similarity
messages: Belongs to the HEATR5 family.

61622:NPBWR2
gene id: 61622:NPBWR2
uniprot id: A0A2K6N9L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:ERN2
gene id: 61622:ERN2
uniprot id: A0A2K6ND21
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:GALC
gene id: 61622:GALC
uniprot id: A0A2K6PKZ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 59 family.

61622:RPL22L1
gene id: 61622:RPL22L1
uniprot id: A0A2K6QWS8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

61622:AP1S3
gene id: 61622:AP1S3
uniprot id: A0A2K6PAR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

61622:RAF1
gene id: 61622:RAF1
uniprot id: A0A2K6R7F9
uniprot id: A0A2K6R7G0
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

61622:ANKH
gene id: 61622:ANKH
uniprot id: A0A2K6QXA0
uniprot id: A0A2K6QXF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

61622:CCNQ
gene id: 61622:CCNQ
uniprot id: A0A2K6QKE5
names: Similarity
messages: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.

61622:HNRNPK
gene id: 61622:HNRNPK
uniprot id: A0A2K6PEY0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

61622:NDUFAF1
gene id: 61622:NDUFAF1
uniprot id: A0A2K6RA71
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

61622:DNAJC18
gene id: 61622:DNAJC18
uniprot id: A0A2K6P9A9
names: Subcellular Location Annotation
messages: Membrane

61622:NOP58
gene id: 61622:NOP58
uniprot id: A0A2K6QI36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

61622:SRSF4
gene id: 61622:SRSF4
uniprot id: A0A2K6P0Q0
names: Similarity
messages: Belongs to the splicing factor SR family.

61622:ERG28
gene id: 61622:ERG28
uniprot id: A0A2K6RJL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PTP4A3
gene id: 61622:PTP4A3
uniprot id: A0A2K6Q6U8
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

61622:LGMN
gene id: 61622:LGMN
uniprot id: A0A2K6RQI2
names: Similarity
messages: Belongs to the peptidase C13 family.

61622:RPL7A
gene id: 61622:RPL7A
uniprot id: A0A2K6PPY6
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

61622:KIF15
gene id: 61622:KIF15
uniprot id: A0A2K6PLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

61622:TCP11L1
gene id: 61622:TCP11L1
uniprot id: A0A2K6QAF5
names: Similarity
messages: Belongs to the TCP11 family.

61622:TNFAIP2
gene id: 61622:TNFAIP2
uniprot id: A0A2K6QPF3
names: Similarity
messages: Belongs to the SEC6 family.

61622:KCNA7
gene id: 61622:KCNA7
uniprot id: A0A2K6RVR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:LOC104679365
gene id: 61622:LOC104679365
uniprot id: A0A2K6NA85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

61622:KRT5
gene id: 61622:KRT5
uniprot id: A0A2K6PXX9
names: Similarity
messages: Belongs to the intermediate filament family.

61622:TUSC3
gene id: 61622:TUSC3
uniprot id: A0A2K6P509
uniprot id: A0A2K6P519
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:MCM9
gene id: 61622:MCM9
uniprot id: A0A2K6R2P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

61622:GRP
gene id: 61622:GRP
uniprot id: A0A2K6QR84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
messages: Secreted
messages: neuron projection
messages: secretory vesicle lumen

61622:ALKBH3
gene id: 61622:ALKBH3
uniprot id: A0A2K6R917
names: Similarity
messages: Belongs to the alkB family.

61622:ATG13
gene id: 61622:ATG13
uniprot id: A0A2K6PAZ8
uniprot id: A0A2K6PB07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

61622:INCENP
gene id: 61622:INCENP
uniprot id: A0A2K6P749
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Midbody
messages: Nucleus
messages: kinetochore
messages: spindle

61622:MAPRE3
gene id: 61622:MAPRE3
uniprot id: A0A2K6QSG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

61622:GPR180
gene id: 61622:GPR180
uniprot id: A0A2K6PHE5
names: Subcellular Location Annotation
messages: Membrane

61622:RIPOR2
gene id: 61622:RIPOR2
uniprot id: A0A2K6QTT0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the RIPOR family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: stereocilium membrane

61622:MOB1B
gene id: 61622:MOB1B
uniprot id: A0A2K6NCH6
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:LZTS2
gene id: 61622:LZTS2
uniprot id: A0A2K6RP64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

61622:GLYCTK
gene id: 61622:GLYCTK
uniprot id: A0A2K6Q6M5
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

61622:CLDN7
gene id: 61622:CLDN7
uniprot id: A0A2K6PEJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:RAD21
gene id: 61622:RAD21
uniprot id: A0A2K6NN66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

61622:AGPAT1
gene id: 61622:AGPAT1
uniprot id: A0A2K6PKR6
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

61622:LOC104659774
gene id: 61622:LOC104659774
uniprot id: A0A2K6QB15
names: Similarity
messages: Belongs to the histone H2B family.

61622:SLC44A3
gene id: 61622:SLC44A3
uniprot id: A0A2K6RJ37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

61622:ATP6V1D
gene id: 61622:ATP6V1D
uniprot id: A0A2K6QUQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase D subunit family.
messages: cilium
messages: clathrin-coated vesicle membrane

61622:GAMT
gene id: 61622:GAMT
uniprot id: A0A2K6PDE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.
messages: Monomer.

61622:PENK
gene id: 61622:PENK
uniprot id: A0A2K6NS21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.
messages: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
messages: Secreted
messages: chromaffin granule lumen

61622:FBXL5
gene id: 61622:FBXL5
uniprot id: A0A2K6RIS5
names: Subcellular Location Annotation
messages: perinuclear region

61622:DUT
gene id: 61622:DUT
uniprot id: A0A2K6R6V6
uniprot id: A0A2K6R6V8
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

61622:CFL2
gene id: 61622:CFL2
uniprot id: A0A2K6QBL4
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

61622:PPP6C
gene id: 61622:PPP6C
uniprot id: A0A2K6PCK7
names: Similarity
messages: Belongs to the PPP phosphatase family.

61622:CCNC
gene id: 61622:CCNC
uniprot id: A0A2K6PMF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
messages: Nucleus

61622:AP3S1
gene id: 61622:AP3S1
uniprot id: A0A2K6NE38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

61622:PIWIL2
gene id: 61622:PIWIL2
uniprot id: A0A2K6QH59
names: Similarity
messages: Belongs to the argonaute family.

61622:NRF1
gene id: 61622:NRF1
uniprot id: A0A2K6P885
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

61622:TRPC4
gene id: 61622:TRPC4
uniprot id: A0A2K6NL94
uniprot id: A0A2K6NLA0
uniprot id: A0A2K6NLA5
uniprot id: A0A2K6NLA7
names: Subcellular Location Annotation
messages: Membrane

61622:EXT1
gene id: 61622:EXT1
uniprot id: A0A2K6PGQ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.
messages: Membrane
messages: cis-Golgi network membrane

61622:SLC9A5
gene id: 61622:SLC9A5
uniprot id: A0A2K6RTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Membrane

61622:SLC7A14
gene id: 61622:SLC7A14
uniprot id: A0A2K6Q6P1
names: Subcellular Location Annotation
messages: Membrane

61622:PPAT
gene id: 61622:PPAT
uniprot id: A0A2K6RMV5
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

61622:LOC104656300
gene id: 61622:LOC104656300
uniprot id: A0A2K6NAL7
names: Subcellular Location Annotation
messages: Membrane

61622:E2F4
gene id: 61622:E2F4
uniprot id: A0A2K6Q4G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

61622:MSN
gene id: 61622:MSN
uniprot id: A0A2K6P6A6
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61622:PSMA8
gene id: 61622:PSMA8
uniprot id: A0A2K6NHB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:ING4
gene id: 61622:ING4
uniprot id: A0A2K6QW58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

61622:AATF
gene id: 61622:AATF
uniprot id: A0A2K6QE37
names: Similarity
messages: Belongs to the AATF family.

61622:AQP7
gene id: 61622:AQP7
uniprot id: A0A2K6PQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

61622:YDJC
gene id: 61622:YDJC
uniprot id: A0A2K6NC04
names: Function
names: Similarity
messages: Belongs to the YdjC deacetylase family.
messages: Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.

61622:LAPTM4A
gene id: 61622:LAPTM4A
uniprot id: A0A2K6RWT7
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

61622:MTFR2
gene id: 61622:MTFR2
uniprot id: A0A2K6PX24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

61622:GAREM2
gene id: 61622:GAREM2
uniprot id: A0A2K6PWV0
names: Similarity
messages: Belongs to the GAREM family.

61622:RAMP2
gene id: 61622:RAMP2
uniprot id: A0A2K6RM81
names: Similarity
messages: Belongs to the RAMP family.

61622:PLA2G2A
gene id: 61622:PLA2G2A
uniprot id: A0A2K6QZD0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

61622:RPS11
gene id: 61622:RPS11
uniprot id: A0A2K6RW45
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

61622:TMPRSS11F
gene id: 61622:TMPRSS11F
uniprot id: A0A2K6RGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

61622:SHROOM3
gene id: 61622:SHROOM3
uniprot id: A0A2K6RPU3
uniprot id: A0A2K6RPU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

61622:SPTLC2
gene id: 61622:SPTLC2
uniprot id: A0A2K6R372
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

61622:ZSCAN1
gene id: 61622:ZSCAN1
uniprot id: A0A2K6Q403
names: Subcellular Location Annotation
messages: Nucleus

61622:GJB2
gene id: 61622:GJB2
uniprot id: A0A2K6NI40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:CTU1
gene id: 61622:CTU1
uniprot id: A0A2K6Q4J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.

61622:TMA16
gene id: 61622:TMA16
uniprot id: A0A2K6PFK6
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

61622:TSC22D4
gene id: 61622:TSC22D4
uniprot id: A0A2K6RE81
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61622:FNBP1L
gene id: 61622:FNBP1L
uniprot id: A0A2K6PW05
uniprot id: A0A2K6PW16
uniprot id: A0A2K6PW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNBP1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Vesicle
messages: cell cortex
messages: cytoskeleton

61622:DYNC1I1
gene id: 61622:DYNC1I1
uniprot id: A0A2K6QBZ0
names: Similarity
messages: Belongs to the dynein intermediate chain family.

61622:CCR10
gene id: 61622:CCR10
uniprot id: A0A2K6PP96
names: Function
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

61622:AADACL2
gene id: 61622:AADACL2
uniprot id: A0A2K6PN49
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

61622:CACUL1
gene id: 61622:CACUL1
uniprot id: A0A2K6Q8Z3
names: Similarity
messages: Belongs to the cullin family.

61622:PPP1R1A
gene id: 61622:PPP1R1A
uniprot id: A0A2K6QP89
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 1 family.

61622:NOL10
gene id: 61622:NOL10
uniprot id: A0A2K6RFP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

61622:RARRES2
gene id: 61622:RARRES2
uniprot id: A0A2K6NTI8
names: Subcellular Location Annotation
messages: Secreted

61622:USP30
gene id: 61622:USP30
uniprot id: A0A2K6RVV2
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:TRAM2
gene id: 61622:TRAM2
uniprot id: A0A2K6Q6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

61622:SPIRE2
gene id: 61622:SPIRE2
uniprot id: A0A2K6NGC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

61622:ZFPM2
gene id: 61622:ZFPM2
uniprot id: A0A2K6PI43
names: Subcellular Location Annotation
messages: Nucleus

61622:F3
gene id: 61622:F3
uniprot id: A0A2K6NUF3
uniprot id: A0A2K6NUG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

61622:CEBPZ
gene id: 61622:CEBPZ
uniprot id: A0A2K6RUK4
names: Similarity
messages: Belongs to the CBF/MAK21 family.

61622:RPL29
gene id: 61622:RPL29
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:LHX8
gene id: 61622:LHX8
uniprot id: A0A2K6PGX9
uniprot id: A0A2K6PH04
names: Subcellular Location Annotation
messages: Nucleus

61622:SPP1
gene id: 61622:SPP1
uniprot id: A0A2K6QIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteopontin family.
messages: Secreted

61622:LOC104674527
gene id: 61622:LOC104674527
uniprot id: A0A2K6NNV5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:GABRE
gene id: 61622:GABRE
uniprot id: A0A2K6R445
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:TM4SF1
gene id: 61622:TM4SF1
uniprot id: A0A2K6NT77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

61622:ADAMTS1
gene id: 61622:ADAMTS1
uniprot id: A0A2K6R4Z1
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:CHRNB1
gene id: 61622:CHRNB1
uniprot id: A0A2K6PYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:STARD5
gene id: 61622:STARD5
uniprot id: A0A2K6RXW9
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

61622:SMPDL3A
gene id: 61622:SMPDL3A
uniprot id: A0A2K6N6Z5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

61622:INSL6
gene id: 61622:INSL6
uniprot id: A0A2K6N735
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

61622:PDE6B
gene id: 61622:PDE6B
uniprot id: A0A2K6RDG8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

61622:PADI4
gene id: 61622:PADI4
uniprot id: A0A2K6QP15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

61622:NME9
gene id: 61622:NME9
uniprot id: A0A2K6Q2U2
names: Similarity
messages: Belongs to the NDK family.

61622:MCPH1
gene id: 61622:MCPH1
uniprot id: A0A2K6NTA2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

61622:LOC104657006
gene id: 61622:LOC104657006
uniprot id: A0A2K6RQ54
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

61622:PTX3
gene id: 61622:PTX3
uniprot id: A0A2K6Q438
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SCN9A
gene id: 61622:SCN9A
uniprot id: A0A2K6Q6T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel (TC 1.A.1.10) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
messages: Membrane

61622:IFITM5
gene id: 61622:IFITM5
uniprot id: A0A2K6NJN0
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:DUSP4
gene id: 61622:DUSP4
uniprot id: A0A2K6NM58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

61622:GADD45GIP1
gene id: 61622:GADD45GIP1
uniprot id: A0A2K6PK71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

61622:ABRAXAS1
gene id: 61622:ABRAXAS1
uniprot id: A0A2K6P0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
messages: Nucleus

61622:TNFRSF1A
gene id: 61622:TNFRSF1A
uniprot id: A0A2K6NYW5
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:APOC1
gene id: 61622:APOC1
uniprot id: A0A2K6QV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C1 family.
messages: Secreted

61622:ARSJ
gene id: 61622:ARSJ
uniprot id: A0A2K6Q414
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

61622:TRAM1
gene id: 61622:TRAM1
uniprot id: A0A2K6PQB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

61622:ADIPOR2
gene id: 61622:ADIPOR2
uniprot id: A0A2K6NKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:DDC
gene id: 61622:DDC
uniprot id: A0A2K6QIQ8
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61622:HS3ST2
gene id: 61622:HS3ST2
uniprot id: A0A2K6NVJ3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:BOLA2B
gene id: 61622:BOLA2B
uniprot id: A0A2K6R415
names: Similarity
messages: Belongs to the BolA/IbaG family.

61622:AKT2
gene id: 61622:AKT2
uniprot id: A0A2K6RHX8
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

61622:LOC104653722
gene id: 61622:LOC104653722
uniprot id: A0A2K6QIS6
uniprot id: A0A2K6QIT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

61622:LOC104665915
gene id: 61622:LOC104665915
uniprot id: A0A2K6P455
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:LOC104667533
gene id: 61622:LOC104667533
uniprot id: A0A2K6NQ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:FABP12
gene id: 61622:FABP12
uniprot id: A0A2K6QKU5
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:SNF8
gene id: 61622:SNF8
uniprot id: A0A2K6R246
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

61622:ADM
gene id: 61622:ADM
uniprot id: A0A2K6QVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

61622:LOC104674747
gene id: 61622:LOC104674747
uniprot id: A0A2K6PZQ8
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:RCAN2
gene id: 61622:RCAN2
uniprot id: A0A2K6PIC6
uniprot id: A0A2K6PIE6
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

61622:ROGDI
gene id: 61622:ROGDI
uniprot id: A0A2K6QKW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rogdi family.
messages: Perikaryon
messages: Presynapse
messages: synaptic vesicle

61622:LOC104667685
gene id: 61622:LOC104667685
uniprot id: A0A2K6P455
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

61622:TBX4
gene id: 61622:TBX4
uniprot id: A0A2K6P1V5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:GPR83
gene id: 61622:GPR83
uniprot id: A0A2K6PKH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

61622:CACNB3
gene id: 61622:CACNB3
uniprot id: A0A2K6R2H7
uniprot id: A0A2K6R2I8
uniprot id: A0A2K6R2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

61622:SYNPR
gene id: 61622:SYNPR
uniprot id: A0A2K6N9I9
uniprot id: A0A2K6N9K2
uniprot id: A0A2K6N9L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

61622:METAP2
gene id: 61622:METAP2
uniprot id: A0A2K6P5Z4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.
messages: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm
messages: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

61622:LOC104656797
gene id: 61622:LOC104656797
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:NUMBL
gene id: 61622:NUMBL
uniprot id: A0A2K6R5X2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a role in the process of neurogenesis.

61622:UCKL1
gene id: 61622:UCKL1
uniprot id: A0A2K6PQW4
names: Similarity
messages: Belongs to the uridine kinase family.

61622:SEPTIN2
gene id: 61622:SEPTIN2
uniprot id: A0A2K6PEU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

61622:CSNK1G1
gene id: 61622:CSNK1G1
uniprot id: A0A2K6QLU7
uniprot id: A0A2K6QLW1
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

61622:ZIC4
gene id: 61622:ZIC4
uniprot id: A0A2K6NVW7
uniprot id: A0A2K6NVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

61622:SPOP
gene id: 61622:SPOP
uniprot id: A0A2K6RLM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tdpoz family.
messages: Nucleus speckle

61622:MTX2
gene id: 61622:MTX2
uniprot id: A0A2K6P5P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:CD40
gene id: 61622:CD40
uniprot id: A0A2K6Q9B7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:PTPN6
gene id: 61622:PTPN6
uniprot id: A0A2K6QK19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

61622:LOC104654533
gene id: 61622:LOC104654533
uniprot id: A0A2K6NJG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:NUTM2F
gene id: 61622:NUTM2F
uniprot id: A0A2K6PVP0
uniprot id: A0A2K6PVP9
names: Similarity
messages: Belongs to the NUT family.

61622:SPTY2D1
gene id: 61622:SPTY2D1
uniprot id: A0A2K6QNQ4
names: Similarity
messages: Belongs to the SPT2 family.

61622:NPVF
gene id: 61622:NPVF
uniprot id: A0A2K6QET7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

61622:MGP
gene id: 61622:MGP
uniprot id: A0A2K6NPE7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

61622:ANTXR2
gene id: 61622:ANTXR2
uniprot id: A0A2K6NHW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

61622:RCAN1
gene id: 61622:RCAN1
uniprot id: A0A2K6NWM6
uniprot id: A0A2K6NWP3
names: Similarity
messages: Belongs to the RCAN family.

61622:CLIC1
gene id: 61622:CLIC1
uniprot id: A0A2K6NP18
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

61622:LOC104659611
gene id: 61622:LOC104659611
uniprot id: A0A2K6PIT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

61622:ABCB11
gene id: 61622:ABCB11
uniprot id: A0A2K6PY90
names: Subcellular Location Annotation
messages: Endosome

61622:NAP1L3
gene id: 61622:NAP1L3
uniprot id: A0A2K6QCS4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61622:LOC104666621
gene id: 61622:LOC104666621
uniprot id: A0A2K6QH37
names: Similarity
messages: Belongs to the MHC class II family.

61622:SLC24A5
gene id: 61622:SLC24A5
uniprot id: A0A2K6QBJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

61622:GABRA4
gene id: 61622:GABRA4
uniprot id: A0A2K6RII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:PKM
gene id: 61622:PKM
uniprot id: A0A2K6QME9
uniprot id: A0A2K6QMG8
names: Similarity
messages: Belongs to the pyruvate kinase family.

61622:NAMPT
gene id: 61622:NAMPT
uniprot id: A0A2K6Q253
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

61622:ABCC8
gene id: 61622:ABCC8
uniprot id: A0A2K6QNK9
names: Subunit
messages: Interacts with KCNJ11.

61622:MAT1A
gene id: 61622:MAT1A
uniprot id: A0A2K6NZ67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

61622:UBE2F
gene id: 61622:UBE2F
uniprot id: A0A2K6RFJ1
uniprot id: A0A2K6RFM2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:TIMM8A
gene id: 61622:TIMM8A
uniprot id: A0A2K6R5F1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

61622:IER3IP1
gene id: 61622:IER3IP1
uniprot id: A0A2K6RB02
names: Similarity
messages: Belongs to the YOS1 family.

61622:ERLIN1
gene id: 61622:ERLIN1
uniprot id: A0A2K6RB38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

61622:SEPTIN12
gene id: 61622:SEPTIN12
uniprot id: A0A2K6NWN0
uniprot id: A0A2K6NWN1
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

61622:KCTD9
gene id: 61622:KCTD9
uniprot id: A0A2K6PJ69
names: Subcellular Location Annotation
messages: Cell membrane

61622:MFSD8
gene id: 61622:MFSD8
uniprot id: A0A2K6PL37
uniprot id: A0A2K6PL42
names: Subcellular Location Annotation
messages: Membrane

61622:CORO1B
gene id: 61622:CORO1B
uniprot id: A0A2K6QR40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat coronin family.
messages: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction.
messages: stress fiber

61622:PTGER2
gene id: 61622:PTGER2
uniprot id: A0A2K6NIX1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:FAM102B
gene id: 61622:FAM102B
uniprot id: A0A2K6R7J5
names: Similarity
messages: Belongs to the FAM102 family.

61622:SNRPA1
gene id: 61622:SNRPA1
uniprot id: A0A2K6QL88
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

61622:CENPC
gene id: 61622:CENPC
uniprot id: A0A2K6PW20
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

61622:RANGRF
gene id: 61622:RANGRF
uniprot id: A0A2K6PKR9
names: Similarity
messages: Belongs to the MOG1 family.

61622:ARRDC2
gene id: 61622:ARRDC2
uniprot id: A0A2K6PJA1
names: Similarity
messages: Belongs to the arrestin family.

61622:CNN2
gene id: 61622:CNN2
uniprot id: A0A2K6NZ13
names: Function
names: Similarity
messages: Belongs to the calponin family.
messages: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

61622:MFSD14A
gene id: 61622:MFSD14A
uniprot id: A0A2K6Q7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

61622:NIPAL2
gene id: 61622:NIPAL2
uniprot id: A0A2K6NB48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

61622:SERPINA11
gene id: 61622:SERPINA11
uniprot id: A0A2K6P518
names: Similarity
messages: Belongs to the serpin family.

61622:SBNO1
gene id: 61622:SBNO1
uniprot id: A0A2K6PW10
names: Similarity
messages: Belongs to the SBNO family.

61622:RPS19BP1
gene id: 61622:RPS19BP1
uniprot id: A0A2K6QLT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AROS family.
messages: nucleolus

61622:NBN
gene id: 61622:NBN
uniprot id: A0A2K6QEN2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
messages: Component of the MRN complex.
messages: Nucleus
messages: telomere

61622:FAM53C
gene id: 61622:FAM53C
uniprot id: A0A2K6RTU7
names: Similarity
messages: Belongs to the FAM53 family.

61622:CDCA7L
gene id: 61622:CDCA7L
uniprot id: A0A2K6QKR2
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:CNP
gene id: 61622:CNP
uniprot id: A0A2K6P3T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

61622:NGLY1
gene id: 61622:NGLY1
uniprot id: A0A2K6Q217
uniprot id: A0A2K6Q228
uniprot id: A0A2K6Q231
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

61622:HABP2
gene id: 61622:HABP2
uniprot id: A0A2K6NSM1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CAPZA3
gene id: 61622:CAPZA3
uniprot id: A0A2K6NMD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

61622:CEP19
gene id: 61622:CEP19
uniprot id: A0A2K6NZC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP19 family.
messages: centriole
messages: cilium basal body
messages: spindle pole

61622:ATP4B
gene id: 61622:ATP4B
uniprot id: A0A2K6Q1E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

61622:CAMK2A
gene id: 61622:CAMK2A
uniprot id: A0A2K6PNT9
uniprot id: A0A2K6PNU5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

61622:SLC35C2
gene id: 61622:SLC35C2
uniprot id: A0A2K6PUZ5
names: Subcellular Location Annotation
messages: Membrane

61622:OPRM1
gene id: 61622:OPRM1
uniprot id: A0A2K6R6H1
uniprot id: A0A2K6R6I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: axon
messages: dendrite

61622:GPLD1
gene id: 61622:GPLD1
uniprot id: A0A2K6PZG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

61622:TIGD7
gene id: 61622:TIGD7
uniprot id: A0A2K6ND56
names: Subcellular Location Annotation
messages: Nucleus

61622:GTF2F1
gene id: 61622:GTF2F1
uniprot id: A0A2K6NKV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

61622:NUDT21
gene id: 61622:NUDT21
uniprot id: A0A2K6PZG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

61622:PLP2
gene id: 61622:PLP2
uniprot id: A0A2K6PUH2
names: Subcellular Location Annotation
messages: Membrane

61622:SPCS1
gene id: 61622:SPCS1
uniprot id: A0A2K6RPB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:HSD17B3
gene id: 61622:HSD17B3
uniprot id: A0A2K6N8U1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:LOC104653731
gene id: 61622:LOC104653731
uniprot id: A0A2K6QC75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:SRD5A2
gene id: 61622:SRD5A2
uniprot id: A0A2K6RXA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

61622:RGMA
gene id: 61622:RGMA
uniprot id: A0A2K6PT26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

61622:CASP3
gene id: 61622:CASP3
uniprot id: A0A2K6PL28
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:SIRT4
gene id: 61622:SIRT4
uniprot id: A0A2K6NZG3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

61622:ANK1
gene id: 61622:ANK1
uniprot id: A0A2K6NSS8
uniprot id: A0A2K6NSV3
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

61622:STAG2
gene id: 61622:STAG2
uniprot id: A0A2K6Q6G7
uniprot id: A0A2K6Q6H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

61622:TGFA
gene id: 61622:TGFA
uniprot id: A0A2K6RB90
uniprot id: A0A2K6RBD7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TBPL1
gene id: 61622:TBPL1
uniprot id: A0A2K6QX77
names: Similarity
names: Subunit
messages: Belongs to the TBP family.
messages: Binds TFIIA and TFIIB.

61622:LOC104670908
gene id: 61622:LOC104670908
uniprot id: A0A2K6NKD2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:EIF4G3
gene id: 61622:EIF4G3
uniprot id: A0A2K6R491
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

61622:TBX18
gene id: 61622:TBX18
uniprot id: A0A2K6PX07
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:NETO1
gene id: 61622:NETO1
uniprot id: A0A2K6Q2Q6
uniprot id: A0A2K6Q2R5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ARPC5L
gene id: 61622:ARPC5L
uniprot id: A0A2K6R2D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
messages: May be a component of the Arp2/3 complex in which it may replace ARPC5.
messages: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

61622:ZNF446
gene id: 61622:ZNF446
uniprot id: A0A2K6RIY1
names: Subcellular Location Annotation
messages: Nucleus

61622:HMOX1
gene id: 61622:HMOX1
uniprot id: A0A2K6R7E8
names: Similarity
messages: Belongs to the heme oxygenase family.

61622:HAO2
gene id: 61622:HAO2
uniprot id: A0A2K6RFU6
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

61622:CACNB4
gene id: 61622:CACNB4
uniprot id: A0A2K6RLW4
uniprot id: A0A2K6RLX0
uniprot id: A0A2K6RLX1
uniprot id: A0A2K6RLX3
names: Similarity
messages: Belongs to the calcium channel beta subunit family.

61622:SLC16A3
gene id: 61622:SLC16A3
uniprot id: A0A2K6PGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

61622:FAM174A
gene id: 61622:FAM174A
uniprot id: A0A2K6QNW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

61622:EIF4ENIF1
gene id: 61622:EIF4ENIF1
uniprot id: A0A2K6P317
uniprot id: A0A2K6P336
names: Subcellular Location Annotation
messages: Cytoplasm

61622:IARS1
gene id: 61622:IARS1
uniprot id: A0A2K6NXR2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:ZSCAN25
gene id: 61622:ZSCAN25
uniprot id: A0A2K6RGH0
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104677288
gene id: 61622:LOC104677288
uniprot id: A0A2K6NR35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:PIH1D1
gene id: 61622:PIH1D1
uniprot id: A0A2K6R943
names: Similarity
messages: Belongs to the PIH1 family.

61622:SSRP1
gene id: 61622:SSRP1
uniprot id: A0A2K6PZG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

61622:CDC34
gene id: 61622:CDC34
uniprot id: A0A2K6PVJ6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:PADI3
gene id: 61622:PADI3
uniprot id: A0A2K6RNL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

61622:PHACTR2
gene id: 61622:PHACTR2
uniprot id: A0A2K6PYU6
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

61622:HOXA6
gene id: 61622:HOXA6
uniprot id: A0A2K6QA95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:RPL7L1
gene id: 61622:RPL7L1
uniprot id: A0A2K6PQ93
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

61622:MCU
gene id: 61622:MCU
uniprot id: A0A2K6RQ21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

61622:KCNH1
gene id: 61622:KCNH1
uniprot id: A0A2K6NFP7
names: Subcellular Location Annotation
messages: Membrane

61622:HSPB8
gene id: 61622:HSPB8
uniprot id: A0A2K6NTK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.
messages: Nucleus

61622:TALDO1
gene id: 61622:TALDO1
uniprot id: A0A2K6R545
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

61622:PTS
gene id: 61622:PTS
uniprot id: A0A2K6PRC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

61622:TNPO1
gene id: 61622:TNPO1
uniprot id: A0A2K6Q291
names: Subcellular Location Annotation
messages: Cytoplasm

61622:SFXN5
gene id: 61622:SFXN5
uniprot id: A0A2K6PLK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

61622:FOXP1
gene id: 61622:FOXP1
uniprot id: A0A2K6RRI0
uniprot id: A0A2K6RRJ9
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC12A9
gene id: 61622:SLC12A9
uniprot id: A0A2K6NZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

61622:IHH
gene id: 61622:IHH
uniprot id: A0A2K6RHE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: Secreted
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

61622:PSEN2
gene id: 61622:PSEN2
uniprot id: A0A2K6PAS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

61622:ELOVL1
gene id: 61622:ELOVL1
uniprot id: A0A2K6NW42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

61622:GBE1
gene id: 61622:GBE1
uniprot id: A0A2K6PB45
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

61622:LSM1
gene id: 61622:LSM1
uniprot id: A0A2K6Q6Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

61622:SFRP5
gene id: 61622:SFRP5
uniprot id: A0A2K6P6X5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:IL1R1
gene id: 61622:IL1R1
uniprot id: A0A2K6P4G6
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:WDR48
gene id: 61622:WDR48
uniprot id: A0A2K6P1W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR48 family.
messages: Endosome
messages: Late endosome

61622:HSD17B10
gene id: 61622:HSD17B10
uniprot id: A0A2K6PK79
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:MAPKAPK3
gene id: 61622:MAPKAPK3
uniprot id: A0A2K6PPM5
uniprot id: A0A2K6PPP9
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:DEFB135
gene id: 61622:DEFB135
uniprot id: A0A2K6NWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:SESN1
gene id: 61622:SESN1
uniprot id: A0A2K6QP14
uniprot id: A0A2K6QP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

61622:DYSF
gene id: 61622:DYSF
uniprot id: A0A2K6RSA8
uniprot id: A0A2K6RSC2
uniprot id: A0A2K6RSC6
uniprot id: A0A2K6RSD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferlin family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

61622:TADA1
gene id: 61622:TADA1
uniprot id: A0A2K6N9G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

61622:CAND1
gene id: 61622:CAND1
uniprot id: A0A2K6NYI0
names: Similarity
messages: Belongs to the CAND family.

61622:UBE2D3
gene id: 61622:UBE2D3
uniprot id: A0A2K6PHZ2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:LOC104680071
gene id: 61622:LOC104680071
uniprot id: A0A2K6N8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:LSM5
gene id: 61622:LSM5
uniprot id: A0A2K6NA85
uniprot id: A0A2K6RCU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

61622:HS3ST5
gene id: 61622:HS3ST5
uniprot id: A0A2K6PED0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:RUVBL1
gene id: 61622:RUVBL1
uniprot id: A0A2K6QEF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

61622:NEUROD4
gene id: 61622:NEUROD4
uniprot id: A0A2K6N9C6
names: Subcellular Location Annotation
messages: Nucleus

61622:ATG101
gene id: 61622:ATG101
uniprot id: A0A2K6PU25
names: Similarity
messages: Belongs to the ATG101 family.

61622:ALKAL1
gene id: 61622:ALKAL1
uniprot id: A0A2K6QV79
uniprot id: A0A2K6QVA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

61622:RPL15
gene id: 61622:RPL15
uniprot id: A0A2K6NXX5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:CD200
gene id: 61622:CD200
uniprot id: A0A2K6QUL1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TATDN3
gene id: 61622:TATDN3
uniprot id: A0A2K6R5D2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

61622:CMTM6
gene id: 61622:CMTM6
uniprot id: A0A2K6Q959
names: Subcellular Location Annotation
messages: Membrane

61622:ALDH16A1
gene id: 61622:ALDH16A1
uniprot id: A0A2K6RQR0
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Interacts with SPG21.

61622:LOC104679929
gene id: 61622:LOC104679929
uniprot id: A0A2K6Q041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

61622:SLC29A2
gene id: 61622:SLC29A2
uniprot id: A0A2K6Q5R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

61622:CNOT11
gene id: 61622:CNOT11
uniprot id: A0A2K6PNE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

61622:SERPINH1
gene id: 61622:SERPINH1
uniprot id: A0A2K6PZ92
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

61622:CD68
gene id: 61622:CD68
uniprot id: A0A2K6Q7N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lysosome membrane

61622:YOD1
gene id: 61622:YOD1
uniprot id: A0A2K6RJ95
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

61622:RPL27A
gene id: 61622:RPL27A
uniprot id: A0A2K6Q2X0
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

61622:TLCD3B
gene id: 61622:TLCD3B
uniprot id: A0A2K6NM14
names: Subcellular Location Annotation
messages: Membrane

61622:MAP3K11
gene id: 61622:MAP3K11
uniprot id: A0A2K6PMA3
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

61622:DYNLT1
gene id: 61622:DYNLT1
uniprot id: A0A2K6QCW4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

61622:POGLUT2
gene id: 61622:POGLUT2
uniprot id: A0A2K6PXR4
uniprot id: A0A2K6PXS0
names: Similarity
messages: Belongs to the KDELC family.

61622:FAM102A
gene id: 61622:FAM102A
uniprot id: A0A2K6QBE7
names: Similarity
messages: Belongs to the FAM102 family.

61622:ACKR2
gene id: 61622:ACKR2
uniprot id: A0A2K6NMH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane
messages: Monomer. Can form homodimers. Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARR3; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts with RNF113A; the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and subsequent degradation. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, promotes CXCR4 ubiquitination and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
messages: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.
messages: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

61622:GABRP
gene id: 61622:GABRP
uniprot id: A0A2K6NVJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:CLPS
gene id: 61622:CLPS
uniprot id: A0A2K6PSS2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
messages: Enterostatin has a biological activity as a satiety signal.
messages: Forms a 1:1 stoichiometric complex with pancreatic lipase.
messages: Secreted

61622:TSEN2
gene id: 61622:TSEN2
uniprot id: A0A2K6R2N7
uniprot id: A0A2K6R2P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

61622:FARSB
gene id: 61622:FARSB
uniprot id: A0A2K6P078
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

61622:PRUNE1
gene id: 61622:PRUNE1
uniprot id: A0A2K6QFN0
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

61622:CD44
gene id: 61622:CD44
uniprot id: A0A2K6R1G5
uniprot id: A0A2K6R1G8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

61622:CAT
gene id: 61622:CAT
uniprot id: A0A2K6N8V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

61622:INTS7
gene id: 61622:INTS7
uniprot id: A0A2K6QQY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

61622:VANGL2
gene id: 61622:VANGL2
uniprot id: A0A2K6RW82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

61622:CACFD1
gene id: 61622:CACFD1
uniprot id: A0A2K6NGH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel flower family.
messages: Membrane

61622:ATXN1
gene id: 61622:ATXN1
uniprot id: A0A2K6PL75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

61622:LOC104661013
gene id: 61622:LOC104661013
uniprot id: A0A2K6NCI6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:HOXA9
gene id: 61622:HOXA9
uniprot id: A0A2K6NSN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

61622:SUPT20H
gene id: 61622:SUPT20H
uniprot id: A0A2K6R3T3
names: Similarity
messages: Belongs to the SPT20 family.

61622:SLC6A7
gene id: 61622:SLC6A7
uniprot id: A0A2K6RM32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

61622:RFC4
gene id: 61622:RFC4
uniprot id: A0A2K6P845
names: Similarity
messages: Belongs to the activator 1 small subunits family.

61622:ANKRD34A
gene id: 61622:ANKRD34A
uniprot id: A0A2K6NNT1
names: Similarity
messages: Belongs to the ANKRD34 family.

61622:LOC104671316
gene id: 61622:LOC104671316
uniprot id: A0A2K6NK78
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:GSDMA
gene id: 61622:GSDMA
uniprot id: A0A2K6NJB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

61622:MCM6
gene id: 61622:MCM6
uniprot id: A0A2K6QLR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

61622:PEBP4
gene id: 61622:PEBP4
uniprot id: A0A2K6RVF2
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

61622:PRPSAP1
gene id: 61622:PRPSAP1
uniprot id: A0A2K6PKX2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

61622:MPP4
gene id: 61622:MPP4
uniprot id: A0A2K6NKV7
names: Similarity
messages: Belongs to the MAGUK family.

61622:TCHP
gene id: 61622:TCHP
uniprot id: A0A2K6QEJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCHP family.
messages: cytoskeleton

61622:GLRA1
gene id: 61622:GLRA1
uniprot id: A0A2K6NHU4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite

61622:LOC104681671
gene id: 61622:LOC104681671
uniprot id: A0A2K6PV45
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:RBM3
gene id: 61622:RBM3
uniprot id: A0A2K6PYX6
names: Subcellular Location Annotation
messages: Cytoplasm

61622:STT3B
gene id: 61622:STT3B
uniprot id: A0A2K6NLJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

61622:DNAJA1
gene id: 61622:DNAJA1
uniprot id: A0A2K6P2W7
names: Subcellular Location Annotation
messages: Membrane

61622:BNIP3L
gene id: 61622:BNIP3L
uniprot id: A0A2K6PEW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIP3 family.
messages: Membrane

61622:GSC
gene id: 61622:GSC
uniprot id: A0A2K6QAH5
names: Subcellular Location Annotation
messages: Nucleus

61622:POLR2B
gene id: 61622:POLR2B
uniprot id: A0A2K6NT92
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

61622:TXLNA
gene id: 61622:TXLNA
uniprot id: A0A2K6NA89
names: Similarity
messages: Belongs to the taxilin family.

61622:LBP
gene id: 61622:LBP
uniprot id: A0A2K6NU31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.
messages: Secreted
messages: When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.

61622:PIGZ
gene id: 61622:PIGZ
uniprot id: A0A2K6P0Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TMED3
gene id: 61622:TMED3
uniprot id: A0A2K6P2L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

61622:IL17RB
gene id: 61622:IL17RB
uniprot id: A0A2K6NZC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:RAPSN
gene id: 61622:RAPSN
uniprot id: A0A2K6QWC4
names: Similarity
messages: Belongs to the RAPsyn family.

61622:SLC45A3
gene id: 61622:SLC45A3
uniprot id: A0A2K6NNK9
names: Subcellular Location Annotation
messages: Membrane

61622:MRPL35
gene id: 61622:MRPL35
uniprot id: A0A2K6RVC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Mitochondrion

61622:RPS6KA4
gene id: 61622:RPS6KA4
uniprot id: A0A2K6QXX5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61622:CXCL13
gene id: 61622:CXCL13
uniprot id: A0A2K6RD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:FEZ1
gene id: 61622:FEZ1
uniprot id: A0A2K6PYX8
names: Similarity
messages: Belongs to the zygin family.

61622:SLC30A3
gene id: 61622:SLC30A3
uniprot id: A0A2K6Q5H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

61622:CAND2
gene id: 61622:CAND2
uniprot id: A0A2K6QRT7
names: Similarity
messages: Belongs to the CAND family.

61622:FABP2
gene id: 61622:FABP2
uniprot id: A0A2K6NVE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

61622:FAM72A
gene id: 61622:FAM72A
uniprot id: A0A2K6PS91
names: Similarity
messages: Belongs to the FAM72 family.

61622:AP1G1
gene id: 61622:AP1G1
uniprot id: A0A2K6NQ98
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:YJU2
gene id: 61622:YJU2
uniprot id: A0A2K6NKR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

61622:LYZL6
gene id: 61622:LYZL6
uniprot id: A0A2K6QFB7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

61622:VASP
gene id: 61622:VASP
uniprot id: A0A2K6RPW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: cytoskeleton

61622:GANAB
gene id: 61622:GANAB
uniprot id: A0A2K6QE81
uniprot id: A0A2K6QE85
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

61622:APOA2
gene id: 61622:APOA2
uniprot id: P0DP87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the apolipoprotein A2 family.
messages: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
messages: Monomer. Interacts with NAXE and NDRG1.
messages: Secreted

61622:HKDC1
gene id: 61622:HKDC1
uniprot id: A0A2K6Q4H2
names: Similarity
messages: Belongs to the hexokinase family.

61622:KCNS2
gene id: 61622:KCNS2
uniprot id: A0A2K6NR70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:TTYH1
gene id: 61622:TTYH1
uniprot id: A0A2K6R921
uniprot id: A0A2K6R938
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

61622:ABCG1
gene id: 61622:ABCG1
uniprot id: A0A2K6RWC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

61622:CCL28
gene id: 61622:CCL28
uniprot id: A0A2K6QCT3
uniprot id: A0A2K6QCT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:LOC104681721
gene id: 61622:LOC104681721
uniprot id: A0A2K6NA16
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:BVES
gene id: 61622:BVES
uniprot id: A0A2K6QQV2
names: Similarity
messages: Belongs to the popeye family.

61622:KEG34 p13
gene id: 61622:KEG34_p13
uniprot id: Q15GP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

61622:NID1
gene id: 61622:NID1
uniprot id: A0A2K6NKZ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

61622:HAAO
gene id: 61622:HAAO
uniprot id: A0A2K6NSZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

61622:LUM
gene id: 61622:LUM
uniprot id: A0A2K6RP72
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
messages: Binds to laminin.
messages: extracellular matrix

61622:LOC104681148
gene id: 61622:LOC104681148
uniprot id: A0A2K6NRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SF3A1
gene id: 61622:SF3A1
uniprot id: A0A2K6RRY5
names: Subcellular Location Annotation
messages: Nucleus

61622:RPL38
gene id: 61622:RPL38
uniprot id: A0A2K6NIF4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

61622:KLC4
gene id: 61622:KLC4
uniprot id: A0A2K6RXL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

61622:FGB
gene id: 61622:FGB
uniprot id: A0A2K6REZ3
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

61622:NECAP2
gene id: 61622:NECAP2
uniprot id: A0A2K6P4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

61622:CHST13
gene id: 61622:CHST13
uniprot id: A0A2K6P8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:HTR7
gene id: 61622:HTR7
uniprot id: A0A2K6P5G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SDHC
gene id: 61622:SDHC
uniprot id: A0A2K6QEQ9
uniprot id: A0A2K6QER2
uniprot id: A0A2K6QER8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: The heme is bound between the two transmembrane subunits.

61622:TRABD2A
gene id: 61622:TRABD2A
uniprot id: A0A2K6RT90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

61622:REXO2
gene id: 61622:REXO2
uniprot id: A0A2K6QNG0
names: Similarity
messages: Belongs to the oligoribonuclease family.

61622:PRXL2A
gene id: 61622:PRXL2A
uniprot id: A0A2K6QJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

61622:MOCS2
gene id: 61622:MOCS2
uniprot id: A0A2K6QET5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

61622:GPR119
gene id: 61622:GPR119
uniprot id: A0A2K6NLS0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:LOC104682395
gene id: 61622:LOC104682395
uniprot id: A0A2K6P069
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:LOC104669569
gene id: 61622:LOC104669569
uniprot id: A0A2K6P8M6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

61622:PAFAH1B1
gene id: 61622:PAFAH1B1
uniprot id: A0A2K6NBW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

61622:LOC104658069
gene id: 61622:LOC104658069
uniprot id: A0A2K6PEB6
names: Subcellular Location Annotation
messages: Membrane

61622:GPRC5D
gene id: 61622:GPRC5D
uniprot id: A0A2K6RWL0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:MRM2
gene id: 61622:MRM2
uniprot id: A0A2K6RQL0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

61622:AURKC
gene id: 61622:AURKC
uniprot id: A0A2K6QD98
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

61622:MRPS12
gene id: 61622:MRPS12
uniprot id: A0A2K6P8Y3
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

61622:CALB2
gene id: 61622:CALB2
uniprot id: A0A2K6RQH3
uniprot id: A0A2K6RQI5
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

61622:LOC104681760
gene id: 61622:LOC104681760
uniprot id: A0A2K6N9Z6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:GNAZ
gene id: 61622:GNAZ
uniprot id: A0A2K6NW28
names: Similarity
messages: Belongs to the G-alpha family. G(i/o/t/z) subfamily.

61622:ADAMTS5
gene id: 61622:ADAMTS5
uniprot id: A0A2K6RWC7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:CRB2
gene id: 61622:CRB2
uniprot id: A0A2K6RKY7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SFXN4
gene id: 61622:SFXN4
uniprot id: A0A2K6NGB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

61622:FGF17
gene id: 61622:FGF17
uniprot id: A0A2K6QFZ3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:TPD52L1
gene id: 61622:TPD52L1
uniprot id: A0A2K6QJT0
uniprot id: A0A2K6QJT5
uniprot id: A0A2K6QJU0
uniprot id: A0A2K6QJV1
names: Similarity
messages: Belongs to the TPD52 family.

61622:LOC104665253
gene id: 61622:LOC104665253
uniprot id: A0A2K6NAW1
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

61622:TFAP2D
gene id: 61622:TFAP2D
uniprot id: A0A2K6RHS6
names: Similarity
messages: Belongs to the AP-2 family.

61622:TDRD7
gene id: 61622:TDRD7
uniprot id: A0A2K6Q598
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TDRD7 family.
messages: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.
messages: Cytoplasm
messages: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1.

61622:KIF3B
gene id: 61622:KIF3B
uniprot id: A0A2K6R6W5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:GABRG3
gene id: 61622:GABRG3
uniprot id: A0A2K6R7J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:SETD7
gene id: 61622:SETD7
uniprot id: A0A2K6RCN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.
messages: Nucleus

61622:LSM7
gene id: 61622:LSM7
uniprot id: A0A2K6PUG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

61622:LOC104662965
gene id: 61622:LOC104662965
uniprot id: A0A2K6RP02
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

61622:TPST2
gene id: 61622:TPST2
uniprot id: A0A2K6P2W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

61622:NFIA
gene id: 61622:NFIA
uniprot id: A0A2K6NR60
uniprot id: A0A2K6NR69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

61622:IRAK1BP1
gene id: 61622:IRAK1BP1
uniprot id: A0A2K6PTZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

61622:GPM6A
gene id: 61622:GPM6A
uniprot id: A0A2K6P5G1
uniprot id: A0A2K6P5H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

61622:TET2
gene id: 61622:TET2
uniprot id: A0A2K6NIL5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the TET family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
messages: The zinc ions have a structural role.

61622:LOC104656071
gene id: 61622:LOC104656071
uniprot id: A0A2K6N7V8
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily. Mu family.
messages: Homodimer.

61622:N6AMT1
gene id: 61622:N6AMT1
uniprot id: A0A2K6NTQ3
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

61622:SLC66A1
gene id: 61622:SLC66A1
uniprot id: A0A2K6R946
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104680296
gene id: 61622:LOC104680296
uniprot id: A0A2K6NEH1
names: Similarity
messages: Belongs to the NDK family.

61622:SLC9B2
gene id: 61622:SLC9B2
uniprot id: A0A2K6ND73
names: Subcellular Location Annotation
messages: Membrane

61622:SLC20A2
gene id: 61622:SLC20A2
uniprot id: A0A2K6QGC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

61622:PHC3
gene id: 61622:PHC3
uniprot id: A0A2K6R586
names: Subcellular Location Annotation
messages: Nucleus

61622:THEMIS
gene id: 61622:THEMIS
uniprot id: A0A2K6PM39
names: Similarity
messages: Belongs to the themis family.

61622:NUDCD1
gene id: 61622:NUDCD1
uniprot id: A0A2K6Q341
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:VEGFB
gene id: 61622:VEGFB
uniprot id: A0A2K6N7D2
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

61622:AP4S1
gene id: 61622:AP4S1
uniprot id: A0A2K6NKC3
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

61622:CALU
gene id: 61622:CALU
uniprot id: A0A2K6QUH5
uniprot id: A0A2K6QUI7
uniprot id: A0A2K6QUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus
messages: Melanosome
messages: Membrane
messages: Sarcoplasmic reticulum lumen
messages: Secreted

61622:AP1S1
gene id: 61622:AP1S1
uniprot id: A0A2K6RDX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

61622:RITA1
gene id: 61622:RITA1
uniprot id: A0A2K6NED6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RITA family.
messages: Cytoplasm
messages: Interacts with RBPJ/RBPSUH.
messages: Nucleus
messages: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

61622:ENTPD3
gene id: 61622:ENTPD3
uniprot id: A0A2K6P796
uniprot id: A0A2K6P7C4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

61622:TOP3A
gene id: 61622:TOP3A
uniprot id: A0A2K6NX61
uniprot id: A0A2K6NX72
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

61622:RAB33A
gene id: 61622:RAB33A
uniprot id: A0A2K6P319
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

61622:BTC
gene id: 61622:BTC
uniprot id: A0A2K6PXD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SAMD4A
gene id: 61622:SAMD4A
uniprot id: A0A2K6QMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMAUG family.
messages: Cytoplasm

61622:LOC104668918
gene id: 61622:LOC104668918
uniprot id: A0A2K6Q698
names: Similarity
messages: Belongs to the PRAME family.

61622:FYTTD1
gene id: 61622:FYTTD1
uniprot id: A0A2K6NH27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle

61622:ATP6V1G2
gene id: 61622:ATP6V1G2
uniprot id: A0A2K6NFE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:PLPPR1
gene id: 61622:PLPPR1
uniprot id: A0A2K6NIJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: May play a role in neurite outgrowth and neurogenesis.
messages: Membrane
messages: neuron projection

61622:IDE
gene id: 61622:IDE
uniprot id: A0A2K6NKM2
uniprot id: A0A2K6NKN6
names: Similarity
messages: Belongs to the peptidase M16 family.

61622:TH
gene id: 61622:TH
uniprot id: A0A2K6RK40
uniprot id: A0A2K6RK57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region
messages: synaptic vesicle

61622:CDK8
gene id: 61622:CDK8
uniprot id: A0A2K6R7R9
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:LOXL3
gene id: 61622:LOXL3
uniprot id: A0A2K6RQH8
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

61622:MINPP1
gene id: 61622:MINPP1
uniprot id: A0A2K6P4G9
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

61622:GDPD1
gene id: 61622:GDPD1
uniprot id: A0A2K6R9W5
uniprot id: A0A2K6R9Z8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

61622:LOC104666703
gene id: 61622:LOC104666703
uniprot id: A0A2K6RAH6
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

61622:MRPL47
gene id: 61622:MRPL47
uniprot id: A0A2K6PU94
uniprot id: A0A2K6PU98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

61622:UBE2S
gene id: 61622:UBE2S
uniprot id: A0A2K6RSS2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:LTC4S
gene id: 61622:LTC4S
uniprot id: A0A2K6PTY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CACNA1E
gene id: 61622:CACNA1E
uniprot id: A0A2K6P825
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
messages: Membrane
messages: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.

61622:CLIC5
gene id: 61622:CLIC5
uniprot id: A0A2K6RIU5
uniprot id: A0A2K6RIU9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:CDK5
gene id: 61622:CDK5
uniprot id: A0A2K6PSN5
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:NKAIN3
gene id: 61622:NKAIN3
uniprot id: A0A2K6P5T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

61622:CLPX
gene id: 61622:CLPX
uniprot id: A0A2K6PN36
names: Similarity
messages: Belongs to the ClpX chaperone family.

61622:LOC104657315
gene id: 61622:LOC104657315
uniprot id: A0A2K6NB94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61622:TPPP3
gene id: 61622:TPPP3
uniprot id: A0A2K6Q7B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPPP family.
messages: cytoskeleton

61622:PMM1
gene id: 61622:PMM1
uniprot id: A0A2K6NSU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

61622:PYGL
gene id: 61622:PYGL
uniprot id: A0A2K6RSP1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

61622:BTG3
gene id: 61622:BTG3
uniprot id: A0A2K6QPB1
names: Similarity
messages: Belongs to the BTG family.

61622:PKIG
gene id: 61622:PKIG
uniprot id: A0A2K6P059
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

61622:SLC27A2
gene id: 61622:SLC27A2
uniprot id: A0A2K6RFZ0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:CNGA4
gene id: 61622:CNGA4
uniprot id: A0A2K6QZM1
names: Subcellular Location Annotation
messages: Membrane

61622:IDH3A
gene id: 61622:IDH3A
uniprot id: A0A2K6QA22
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

61622:EML1
gene id: 61622:EML1
uniprot id: A0A2K6NXV0
uniprot id: A0A2K6NXV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat EMAP family.
messages: cytoskeleton

61622:FA2H
gene id: 61622:FA2H
uniprot id: A0A2K6PNR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:ADGRD1
gene id: 61622:ADGRD1
uniprot id: A0A2K6Q534
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CLDN12
gene id: 61622:CLDN12
uniprot id: A0A2K6NR66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

61622:OS9
gene id: 61622:OS9
uniprot id: A0A2K6NGB8
uniprot id: A0A2K6NGE4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

61622:BPNT1
gene id: 61622:BPNT1
uniprot id: A0A2K6NYR3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:UBQLN2
gene id: 61622:UBQLN2
uniprot id: A0A2K6NA79
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus
messages: autophagosome

61622:FAM91A1
gene id: 61622:FAM91A1
uniprot id: A0A2K6QLU2
names: Similarity
messages: Belongs to the FAM91 family.

61622:DPRX
gene id: 61622:DPRX
uniprot id: A0A2K6REF4
names: Subcellular Location Annotation
messages: Nucleus

61622:LITAF
gene id: 61622:LITAF
uniprot id: A0A2K6R383
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

61622:THOC5
gene id: 61622:THOC5
uniprot id: A0A2K6NZX3
uniprot id: A0A2K6P004
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

61622:LCOR
gene id: 61622:LCOR
uniprot id: A0A2K6R6I2
names: Subcellular Location Annotation
messages: Nucleus

61622:GPR25
gene id: 61622:GPR25
uniprot id: A0A2K6NFN6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:VSX1
gene id: 61622:VSX1
uniprot id: A0A2K6RS03
uniprot id: A0A2K6RS10
uniprot id: A0A2K6RS11
names: Subcellular Location Annotation
messages: Nucleus

61622:NPM1
gene id: 61622:NPM1
uniprot id: A0A2K6RTJ9
uniprot id: A0A2K6RTL7
names: Similarity
messages: Belongs to the nucleoplasmin family.

61622:HEBP2
gene id: 61622:HEBP2
uniprot id: A0A2K6PWK0
names: Similarity
messages: Belongs to the HEBP family.

61622:ZDHHC3
gene id: 61622:ZDHHC3
uniprot id: A0A2K6PJ17
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:TIMM17A
gene id: 61622:TIMM17A
uniprot id: A0A2K6RIV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

61622:MSH2
gene id: 61622:MSH2
uniprot id: A0A2K6N8M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

61622:ATP1B1
gene id: 61622:ATP1B1
uniprot id: A0A2K6PEM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Cell membrane
messages: Involved in cell adhesion and establishing epithelial cell polarity.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
messages: sarcolemma

61622:UCP1
gene id: 61622:UCP1
uniprot id: A0A2K6PF86
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

61622:KIF2A
gene id: 61622:KIF2A
uniprot id: A0A2K6N838
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:RLN3
gene id: 61622:RLN3
uniprot id: A0A2K6PJ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

61622:GCHFR
gene id: 61622:GCHFR
uniprot id: A0A2K6QJQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GFRP family.
messages: Membrane
messages: Nucleus membrane
messages: cytosol

61622:CDK2AP2
gene id: 61622:CDK2AP2
uniprot id: A0A2K6RGL5
names: Similarity
messages: Belongs to the CDK2AP family.

61622:BZW1
gene id: 61622:BZW1
uniprot id: A0A2K6RMR8
names: Similarity
messages: Belongs to the BZW family.

61622:ALAD
gene id: 61622:ALAD
uniprot id: A0A2K6Q2Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer; active form. Homohexamer; low activity form.

61622:PROM2
gene id: 61622:PROM2
uniprot id: A0A2K6QPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

61622:PSME1
gene id: 61622:PSME1
uniprot id: A0A2K6RND7
names: Similarity
messages: Belongs to the PA28 family.

61622:CWC25
gene id: 61622:CWC25
uniprot id: A0A2K6QV10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

61622:FXYD4
gene id: 61622:FXYD4
uniprot id: A0A2K6QTF4
names: Similarity
messages: Belongs to the FXYD family.

61622:AKR1A1
gene id: 61622:AKR1A1
uniprot id: A0A2K6RRS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: Monomer.
messages: cytosol

61622:TMEM168
gene id: 61622:TMEM168
uniprot id: A0A2K6QSK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane

61622:UBE4A
gene id: 61622:UBE4A
uniprot id: A0A2K6RPA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

61622:CD3D
gene id: 61622:CD3D
uniprot id: A0A2K6NDT9
names: Subcellular Location Annotation
messages: Membrane

61622:CDK19
gene id: 61622:CDK19
uniprot id: A0A2K6R0T2
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TRAPPC6B
gene id: 61622:TRAPPC6B
uniprot id: A0A2K6QCJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

61622:PREB
gene id: 61622:PREB
uniprot id: A0A2K6QEZ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

61622:ERBIN
gene id: 61622:ERBIN
uniprot id: A0A2K6R0Y6
uniprot id: A0A2K6R0Z2
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

61622:RGS4
gene id: 61622:RGS4
uniprot id: A0A2K6NP72
names: Function
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

61622:LAMTOR2
gene id: 61622:LAMTOR2
uniprot id: A0A2K6RUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

61622:TMEM151A
gene id: 61622:TMEM151A
uniprot id: A0A2K6QNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM151 family.
messages: Membrane

61622:RPL11
gene id: 61622:RPL11
uniprot id: A0A2K6QUX6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

61622:GTF2E2
gene id: 61622:GTF2E2
uniprot id: A0A2K6RBH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

61622:MAP4
gene id: 61622:MAP4
uniprot id: A0A2K6QG05
names: Subcellular Location Annotation
messages: cytoskeleton

61622:LOC104663773
gene id: 61622:LOC104663773
uniprot id: A0A2K6Q750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

61622:EMC7
gene id: 61622:EMC7
uniprot id: A0A2K6QHH3
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

61622:RASGRP4
gene id: 61622:RASGRP4
uniprot id: A0A2K6PK94
names: Similarity
messages: Belongs to the RASGRP family.

61622:DENND10
gene id: 61622:DENND10
uniprot id: A0A2K6QRJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

61622:PCBD2
gene id: 61622:PCBD2
uniprot id: A0A2K6Q0W2
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

61622:SLC25A4
gene id: 61622:SLC25A4
uniprot id: A0A2K6Q1W5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

61622:PRPF19
gene id: 61622:PRPF19
uniprot id: A0A2K6R5A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Lipid droplet
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
messages: nucleoplasm

61622:TDRD9
gene id: 61622:TDRD9
uniprot id: A0A2K6QDT6
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily.

61622:SERF1A
gene id: 61622:SERF1A
uniprot id: A0A2K6QIH5
uniprot id: A0A2K6QIH9
names: Similarity
messages: Belongs to the SERF family.

61622:SHOX2
gene id: 61622:SHOX2
uniprot id: A0A2K6PP43
names: Subcellular Location Annotation
messages: Nucleus

61622:TWSG1
gene id: 61622:TWSG1
uniprot id: A0A2K6RWR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the twisted gastrulation protein family.
messages: Secreted

61622:RPS15A
gene id: 61622:RPS15A
uniprot id: A0A2K6P191
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the 40S ribosomal subunit.

61622:WDR55
gene id: 61622:WDR55
uniprot id: A0A2K6R5Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
messages: nucleolus

61622:RPS16
gene id: 61622:RPS16
uniprot id: A0A2K6NYB8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

61622:ALAS2
gene id: 61622:ALAS2
uniprot id: A0A2K6PVC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

61622:DYNLRB1
gene id: 61622:DYNLRB1
uniprot id: A0A2K6P300
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

61622:ONECUT1
gene id: 61622:ONECUT1
uniprot id: A0A2K6PMV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61622:SNX25
gene id: 61622:SNX25
uniprot id: A0A2K6PUF7
names: Similarity
messages: Belongs to the sorting nexin family.

61622:VRTN
gene id: 61622:VRTN
uniprot id: A0A2K6NE87
names: Similarity
messages: Belongs to the vertnin family.

61622:SGPL1
gene id: 61622:SGPL1
uniprot id: A0A2K6P0W0
names: Similarity
messages: Belongs to the group II decarboxylase family.

61622:MMS19
gene id: 61622:MMS19
uniprot id: A0A2K6QV08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MET18/MMS19 family.
messages: Component of the CIA complex.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus
messages: spindle

61622:SATB2
gene id: 61622:SATB2
uniprot id: A0A2K6RQP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61622:HYAL2
gene id: 61622:HYAL2
uniprot id: A0A2K6NK09
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

61622:GATA1
gene id: 61622:GATA1
uniprot id: A0A2K6Q0U2
names: Subcellular Location Annotation
messages: Nucleus

61622:ATP6V1G1
gene id: 61622:ATP6V1G1
uniprot id: A0A2K6RT79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

61622:LIPG
gene id: 61622:LIPG
uniprot id: A0A2K6PKT0
uniprot id: A0A2K6PL07
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:AK8
gene id: 61622:AK8
uniprot id: A0A2K6NBZ3
names: Similarity
messages: Belongs to the adenylate kinase family.

61622:ACTR1B
gene id: 61622:ACTR1B
uniprot id: A0A2K6PGU9
names: Similarity
messages: Belongs to the actin family.

61622:PLA2G15
gene id: 61622:PLA2G15
uniprot id: A0A2K6Q795
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

61622:FOXN4
gene id: 61622:FOXN4
uniprot id: A0A2K6PIU4
names: Subcellular Location Annotation
messages: Nucleus

61622:DLG1
gene id: 61622:DLG1
uniprot id: A0A2K6P9Z7
uniprot id: A0A2K6PA14
uniprot id: A0A2K6PA70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Membrane

61622:EGR3
gene id: 61622:EGR3
uniprot id: A0A2K6QNG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

61622:PFKFB3
gene id: 61622:PFKFB3
uniprot id: A0A2K6QAL5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

61622:HNF4A
gene id: 61622:HNF4A
uniprot id: A0A2K6P6E4
uniprot id: A0A2K6P6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:HSF4
gene id: 61622:HSF4
uniprot id: A0A2K6RB16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

61622:KEG34 p02
gene id: 61622:KEG34_p02
uniprot id: Q15GN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

61622:GADL1
gene id: 61622:GADL1
uniprot id: A0A2K6RHV5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

61622:WNT10A
gene id: 61622:WNT10A
uniprot id: A0A2K6PDT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

61622:SLC35E4
gene id: 61622:SLC35E4
uniprot id: A0A2K6PZB4
names: Subcellular Location Annotation
messages: Membrane

61622:AP4B1
gene id: 61622:AP4B1
uniprot id: A0A2K6P5Q6
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

61622:BTD
gene id: 61622:BTD
uniprot id: A0A2K6PKA4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

61622:GAP43
gene id: 61622:GAP43
uniprot id: A0A2K6P5I2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Cell membrane
messages: Cytoplasm
messages: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Perikaryon
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: axon
messages: dendrite
messages: filopodium membrane
messages: growth cone membrane

61622:NDUFS6
gene id: 61622:NDUFS6
uniprot id: A0A2K6PRT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

61622:PIGC
gene id: 61622:PIGC
uniprot id: A0A2K6NH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

61622:PDP2
gene id: 61622:PDP2
uniprot id: A0A2K6ND41
names: Similarity
messages: Belongs to the PP2C family.

61622:DHRS7
gene id: 61622:DHRS7
uniprot id: A0A2K6QZZ8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

61622:PDXK
gene id: 61622:PDXK
uniprot id: A0A2K6RNF7
names: Similarity
messages: Belongs to the pyridoxine kinase family.

61622:RMI1
gene id: 61622:RMI1
uniprot id: A0A2K6QEC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

61622:PDE6H
gene id: 61622:PDE6H
uniprot id: A0A2K6RPS5
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

61622:PLSCR2
gene id: 61622:PLSCR2
uniprot id: A0A2K6PC76
uniprot id: A0A2K6PC80
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:ABHD3
gene id: 61622:ABHD3
uniprot id: A0A2K6PXV7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

61622:HSPA5
gene id: 61622:HSPA5
uniprot id: A0A2K6NWE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen

61622:LOC104661582
gene id: 61622:LOC104661582
uniprot id: A0A2K6P7M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

61622:SESN2
gene id: 61622:SESN2
uniprot id: A0A2K6RVA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

61622:MED19
gene id: 61622:MED19
uniprot id: A0A2K6Q2A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:NPY
gene id: 61622:NPY
uniprot id: A0A2K6PZ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

61622:TPD52
gene id: 61622:TPD52
uniprot id: A0A2K6R3Q1
names: Similarity
messages: Belongs to the TPD52 family.

61622:NCOA7
gene id: 61622:NCOA7
uniprot id: A0A2K6PNG5
names: Similarity
messages: Belongs to the OXR1 family.

61622:FAM133A
gene id: 61622:FAM133A
uniprot id: A0A2K6QDT0
names: Similarity
messages: Belongs to the FAM133 family.

61622:MAD1L1
gene id: 61622:MAD1L1
uniprot id: A0A2K6RKF2
names: Similarity
messages: Belongs to the MAD1 family.

61622:CXCL9
gene id: 61622:CXCL9
uniprot id: A0A2K6Q2T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:SERPINB12
gene id: 61622:SERPINB12
uniprot id: A0A2K6Q0P4
names: Similarity
messages: Belongs to the serpin family.

61622:KNG1
gene id: 61622:KNG1
uniprot id: A0A2K6PNE1
names: Subcellular Location Annotation
messages: extracellular space

61622:RHOXF2
gene id: 61622:RHOXF2
uniprot id: A0A2K6QLN6
names: Subcellular Location Annotation
messages: Nucleus

61622:ZNF397
gene id: 61622:ZNF397
uniprot id: A0A2K6NU53
names: Subcellular Location Annotation
messages: Nucleus

61622:KCTD4
gene id: 61622:KCTD4
uniprot id: A0A2K6NK26
names: Subcellular Location Annotation
messages: Cell membrane

61622:LOC104662147
gene id: 61622:LOC104662147
uniprot id: A0A2K6P5K1
names: Similarity
messages: Belongs to the MAGUK family.

61622:NDUFA2
gene id: 61622:NDUFA2
uniprot id: A0A2K6RL30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:FDPS
gene id: 61622:FDPS
uniprot id: A0A2K6QQ60
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

61622:LRRC8C
gene id: 61622:LRRC8C
uniprot id: A0A2K6QZB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

61622:NSRP1
gene id: 61622:NSRP1
uniprot id: A0A2K6PPR4
names: Similarity
messages: Belongs to the NSRP1 family.

61622:RARS1
gene id: 61622:RARS1
uniprot id: A0A2K6RVV3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

61622:SETD2
gene id: 61622:SETD2
uniprot id: A0A2K6P108
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61622:NR4A2
gene id: 61622:NR4A2
uniprot id: A0A2K6PYV4
uniprot id: A0A2K6PYV8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

61622:CD53
gene id: 61622:CD53
uniprot id: A0A2K6PCT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:RPL10
gene id: 61622:RPL10
uniprot id: A0A2K6NK39
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

61622:STING1
gene id: 61622:STING1
uniprot id: A0A2K6RUF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

61622:PLXNA2
gene id: 61622:PLXNA2
uniprot id: A0A2K6Q9R7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:HAO1
gene id: 61622:HAO1
uniprot id: A0A2K6QJC8
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

61622:AHCYL2
gene id: 61622:AHCYL2
uniprot id: A0A2K6Q9W9
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

61622:NDUFA12
gene id: 61622:NDUFA12
uniprot id: A0A2K6PJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:GNG3
gene id: 61622:GNG3
uniprot id: A0A2K6QDH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

61622:SSR1
gene id: 61622:SSR1
uniprot id: A0A2K6Q350
uniprot id: A0A2K6Q360
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
messages: Membrane
messages: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

61622:ATF2
gene id: 61622:ATF2
uniprot id: A0A2K6P0C5
uniprot id: A0A2K6P0C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Binds DNA as a dimer and can form a homodimer in the absence of DNA.
messages: Nucleus
messages: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3').

61622:NBR1
gene id: 61622:NBR1
uniprot id: A0A2K6PV97
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

61622:HMGCL
gene id: 61622:HMGCL
uniprot id: A0A2K6QWG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

61622:COLGALT1
gene id: 61622:COLGALT1
uniprot id: A0A2K6N704
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

61622:DNAJC2
gene id: 61622:DNAJC2
uniprot id: A0A2K6P3I0
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: Nucleus
messages: cytosol

61622:PPP1R12B
gene id: 61622:PPP1R12B
uniprot id: A0A2K6QS03
uniprot id: A0A2K6QS18
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

61622:PAX9
gene id: 61622:PAX9
uniprot id: A0A2K6P269
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KDM5B.
messages: Nucleus
messages: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.

61622:LOC104659826
gene id: 61622:LOC104659826
uniprot id: A0A2K6Q5G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

61622:PPME1
gene id: 61622:PPME1
uniprot id: A0A2K6PDL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily.
messages: Binds PPP2CA and PPP2CB.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

61622:LOC104672886
gene id: 61622:LOC104672886
uniprot id: A0A2K6QCI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:SLC9A2
gene id: 61622:SLC9A2
uniprot id: A0A2K6RGD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Interacts with CHP1 and CHP2.
messages: Membrane

61622:GCH1
gene id: 61622:GCH1
uniprot id: A0A2K6RPE5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

61622:CCDC149
gene id: 61622:CCDC149
uniprot id: A0A2K6R1F4
names: Similarity
messages: Belongs to the CCDC149 family.

61622:RGS3
gene id: 61622:RGS3
uniprot id: A0A2K6PT90
names: Subcellular Location Annotation
messages: Cytoplasm

61622:ABCC9
gene id: 61622:ABCC9
uniprot id: A0A2K6QP55
uniprot id: A0A2K6QP82
uniprot id: A0A2K6QP84
names: Subunit
messages: Interacts with KCNJ11.

61622:GPR68
gene id: 61622:GPR68
uniprot id: A0A2K6NIB5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:GPM6B
gene id: 61622:GPM6B
uniprot id: A0A2K6R6T6
uniprot id: A0A2K6R6T7
uniprot id: A0A2K6R6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

61622:MS4A4A
gene id: 61622:MS4A4A
uniprot id: A0A2K6P6F8
names: Similarity
messages: Belongs to the MS4A family.

61622:LOC104671077
gene id: 61622:LOC104671077
uniprot id: A0A2K6PY35
names: Subcellular Location Annotation
messages: Nucleus

61622:SHC1
gene id: 61622:SHC1
uniprot id: A0A2K6PH10
names: Subcellular Location Annotation
messages: Cytoplasm

61622:DRC1
gene id: 61622:DRC1
uniprot id: A0A2K6RXB2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DRC1 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC).
messages: cilium axoneme
messages: flagellum axoneme

61622:ITPKB
gene id: 61622:ITPKB
uniprot id: A0A2K6PTW3
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

61622:FSCN3
gene id: 61622:FSCN3
uniprot id: A0A2K6RDH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61622:LOC104666771
gene id: 61622:LOC104666771
uniprot id: A0A2K6NIF4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

61622:ACSM3
gene id: 61622:ACSM3
uniprot id: A0A2K6RQH5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:ODF2L
gene id: 61622:ODF2L
uniprot id: A0A2K6PA39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

61622:CFAP53
gene id: 61622:CFAP53
uniprot id: A0A2K6PTI7
names: Similarity
messages: Belongs to the CFAP53 family.

61622:SMARCD2
gene id: 61622:SMARCD2
uniprot id: A0A2K6P5U5
names: Similarity
messages: Belongs to the SMARCD family.

61622:GATA4
gene id: 61622:GATA4
uniprot id: A0A2K6RLM6
names: Subcellular Location Annotation
messages: Nucleus

61622:GSTK1
gene id: 61622:GSTK1
uniprot id: A0A2K6R5S8
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

61622:CIAPIN1
gene id: 61622:CIAPIN1
uniprot id: A0A2K6QDX9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

61622:HEATR1
gene id: 61622:HEATR1
uniprot id: A0A2K6QDP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEATR1/UTP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

61622:SCGB1D4
gene id: 61622:SCGB1D4
uniprot id: A0A2K6QVB0
names: Subcellular Location Annotation
messages: Secreted

61622:POPDC2
gene id: 61622:POPDC2
uniprot id: A0A2K6RNR6
names: Similarity
messages: Belongs to the popeye family.

61622:EIF3K
gene id: 61622:EIF3K
uniprot id: A0A2K6NYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

61622:LOC104655970
gene id: 61622:LOC104655970
uniprot id: A0A2K6QKS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: lamellipodium membrane
messages: ruffle membrane

61622:LOC104672095
gene id: 61622:LOC104672095
uniprot id: A0A2K6PIX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:CARTPT
gene id: 61622:CARTPT
uniprot id: A0A2K6R353
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

61622:PCMTD1
gene id: 61622:PCMTD1
uniprot id: A0A2K6PTS0
uniprot id: A0A2K6PTS7
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

61622:DCTN1
gene id: 61622:DCTN1
uniprot id: A0A2K6P9P1
uniprot id: A0A2K6P9Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin 150 kDa subunit family.
messages: cell cortex
messages: cytoskeleton

61622:HK2
gene id: 61622:HK2
uniprot id: A0A2K6PBD9
uniprot id: A0A2K6PBI3
names: Similarity
messages: Belongs to the hexokinase family.

61622:ATP2A2
gene id: 61622:ATP2A2
uniprot id: A0A2K6RPZ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

61622:BATF
gene id: 61622:BATF
uniprot id: A0A2K6R373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Cytoplasm

61622:CDK9
gene id: 61622:CDK9
uniprot id: A0A2K6R0R0
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:TSPAN1
gene id: 61622:TSPAN1
uniprot id: A0A2K6QHL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

61622:ADAM7
gene id: 61622:ADAM7
uniprot id: A0A2K6P933
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:FGF14
gene id: 61622:FGF14
uniprot id: A0A2K6RFY3
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:LOC104677513
gene id: 61622:LOC104677513
uniprot id: A0A2K6NNH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

61622:ANKRD13C
gene id: 61622:ANKRD13C
uniprot id: A0A2K6REB4
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104679722
gene id: 61622:LOC104679722
uniprot id: A0A2K6REK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

61622:SCRN2
gene id: 61622:SCRN2
uniprot id: A0A2K6QDV6
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

61622:PAIP2
gene id: 61622:PAIP2
uniprot id: A0A2K6R3F3
names: Similarity
messages: Belongs to the PAIP2 family.

61622:C12H1orf52
gene id: 61622:C12H1orf52
uniprot id: A0A2K6NTS6
uniprot id: A0A2K6NTU9
names: Similarity
messages: Belongs to the UPF0690 family.

61622:FSCN1
gene id: 61622:FSCN1
uniprot id: A0A2K6PJ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61622:LOC104680528
gene id: 61622:LOC104680528
uniprot id: A0A2K6R477
names: Similarity
messages: Belongs to the CBP3 family.

61622:IL25
gene id: 61622:IL25
uniprot id: A0A2K6PWF1
uniprot id: A0A2K6PWF2
names: Similarity
messages: Belongs to the IL-17 family.

61622:GRB7
gene id: 61622:GRB7
uniprot id: A0A2K6P135
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

61622:IL1A
gene id: 61622:IL1A
uniprot id: A0A2K6NJ18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: Secreted

61622:MPV17
gene id: 61622:MPV17
uniprot id: A0A2K6PUU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

61622:EML3
gene id: 61622:EML3
uniprot id: A0A2K6REN0
names: Subcellular Location Annotation
messages: cytoskeleton

61622:LOC104675517
gene id: 61622:LOC104675517
uniprot id: A0A2K6Q299
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

61622:NAP1L4
gene id: 61622:NAP1L4
uniprot id: A0A2K6R3K1
uniprot id: A0A2K6R3M5
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

61622:LOC104665241
gene id: 61622:LOC104665241
uniprot id: A0A2K6NP67
names: Similarity
messages: Belongs to the GPATCH1 family.

61622:SPTBN2
gene id: 61622:SPTBN2
uniprot id: A0A2K6RQZ7
uniprot id: A0A2K6RQZ8
names: Similarity
messages: Belongs to the spectrin family.

61622:FDFT1
gene id: 61622:FDFT1
uniprot id: A0A2K6RJ97
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

61622:PDGFRB
gene id: 61622:PDGFRB
uniprot id: A0A2K6R8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

61622:GBP3
gene id: 61622:GBP3
uniprot id: A0A2K6R205
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:RXFP4
gene id: 61622:RXFP4
uniprot id: A0A2K6NGI6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:SPICE1
gene id: 61622:SPICE1
uniprot id: A0A2K6PP02
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

61622:SAP18
gene id: 61622:SAP18
uniprot id: A0A2K6P401
names: Similarity
messages: Belongs to the SAP18 family.

61622:TOMM40L
gene id: 61622:TOMM40L
uniprot id: A0A2K6RQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:SLC33A1
gene id: 61622:SLC33A1
uniprot id: A0A2K6QZK9
names: Subcellular Location Annotation
messages: Membrane

61622:KCNA5
gene id: 61622:KCNA5
uniprot id: A0A2K6NQE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
messages: Cell membrane
messages: Membrane

61622:SNX30
gene id: 61622:SNX30
uniprot id: A0A2K6PSP1
names: Similarity
messages: Belongs to the sorting nexin family.

61622:MMP13
gene id: 61622:MMP13
uniprot id: A0A2K6R9Z3
uniprot id: A0A2K6RA41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
messages: Secreted

61622:BTN2A2
gene id: 61622:BTN2A2
uniprot id: A0A2K6RV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

61622:ETS2
gene id: 61622:ETS2
uniprot id: A0A2K6QU84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

61622:ACOT4
gene id: 61622:ACOT4
uniprot id: A0A2K6Q4J7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

61622:SOX14
gene id: 61622:SOX14
uniprot id: A0A2K6NPT9
names: Subcellular Location Annotation
messages: Nucleus

61622:PDCD10
gene id: 61622:PDCD10
uniprot id: A0A2K6NV76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

61622:OPRD1
gene id: 61622:OPRD1
uniprot id: A0A2K6P159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:MED28
gene id: 61622:MED28
uniprot id: A0A2K6PI78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 28 family.
messages: Nucleus

61622:CPLX2
gene id: 61622:CPLX2
uniprot id: A0A2K6NTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

61622:CRYGS
gene id: 61622:CRYGS
uniprot id: A0A2K6P7E0
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:FGFR1OP
gene id: 61622:FGFR1OP
uniprot id: A0A2K6QR70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

61622:AIMP2
gene id: 61622:AIMP2
uniprot id: A0A2K6RH13
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

61622:BGLAP
gene id: 61622:BGLAP
uniprot id: A0A2K6QIM5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

61622:ADCY9
gene id: 61622:ADCY9
uniprot id: A0A2K6QCR4
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

61622:RORB
gene id: 61622:RORB
uniprot id: A0A2K6QK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

61622:CENPL
gene id: 61622:CENPL
uniprot id: A0A2K6Q0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

61622:TNFAIP6
gene id: 61622:TNFAIP6
uniprot id: A0A2K6R1U2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LOC104654605
gene id: 61622:LOC104654605
uniprot id: A0A2K6RWX3
names: Similarity
messages: Belongs to the 3-beta-HSD family.

61622:ITGAL
gene id: 61622:ITGAL
uniprot id: A0A2K6QK32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:KLHL3
gene id: 61622:KLHL3
uniprot id: A0A2K6N881
names: Subcellular Location Annotation
messages: cytoskeleton
messages: cytosol

61622:LOC104666384
gene id: 61622:LOC104666384
uniprot id: A0A2K6NR15
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:TENT5B
gene id: 61622:TENT5B
uniprot id: A0A2K6RVE0
names: Similarity
messages: Belongs to the TENT family.

61622:GRIK5
gene id: 61622:GRIK5
uniprot id: A0A2K6NN19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:NDUFAF3
gene id: 61622:NDUFAF3
uniprot id: A0A2K6PYP7
names: Function
names: Subcellular Location Annotation
messages: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Membrane
messages: Mitochondrion inner membrane
messages: Nucleus

61622:RUVBL2
gene id: 61622:RUVBL2
uniprot id: A0A2K6P5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

61622:LOC104682241
gene id: 61622:LOC104682241
uniprot id: A0A2K6RXU3
names: Similarity
messages: Belongs to the serpin family.

61622:PPOX
gene id: 61622:PPOX
uniprot id: A0A2K6PS87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

61622:BCL2L14
gene id: 61622:BCL2L14
uniprot id: A0A2K6RK59
names: Similarity
messages: Belongs to the Bcl-2 family.

61622:COPZ1
gene id: 61622:COPZ1
uniprot id: A0A2K6P0E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

61622:MSR1
gene id: 61622:MSR1
uniprot id: A0A2K6N8I5
names: Subcellular Location Annotation
messages: Membrane

61622:ERCC4
gene id: 61622:ERCC4
uniprot id: A0A2K6NLQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

61622:MAP3K8
gene id: 61622:MAP3K8
uniprot id: A0A2K6RPG4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

61622:HNF4G
gene id: 61622:HNF4G
uniprot id: A0A2K6NTC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

61622:ALDH1L2
gene id: 61622:ALDH1L2
uniprot id: A0A2K6PWU6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

61622:KHDC4
gene id: 61622:KHDC4
uniprot id: A0A2K6P6S2
names: Similarity
messages: Belongs to the KHDC4 family.

61622:FES
gene id: 61622:FES
uniprot id: A0A2K6R331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: cytoskeleton

61622:CASQ2
gene id: 61622:CASQ2
uniprot id: A0A2K6PIX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

61622:IPO4
gene id: 61622:IPO4
uniprot id: A0A2K6NF34
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LOC104680824
gene id: 61622:LOC104680824
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:TMEM199
gene id: 61622:TMEM199
uniprot id: A0A2K6QT39
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TOP1
gene id: 61622:TOP1
uniprot id: A0A2K6RG36
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

61622:RNASE4
gene id: 61622:RNASE4
uniprot id: A0A2K6NR06
names: Similarity
messages: Belongs to the pancreatic ribonuclease family.

61622:IZUMO3
gene id: 61622:IZUMO3
uniprot id: A0A2K6NNR7
names: Similarity
messages: Belongs to the Izumo family.

61622:SLC16A14
gene id: 61622:SLC16A14
uniprot id: A0A2K6PDY5
names: Subcellular Location Annotation
messages: Membrane

61622:CALCB
gene id: 61622:CALCB
uniprot id: A0A2K6NEF8
names: Similarity
messages: Belongs to the calcitonin family.

61622:ST3GAL5
gene id: 61622:ST3GAL5
uniprot id: A0A2K6PB34
uniprot id: A0A2K6PB41
uniprot id: A0A2K6PBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:C21H18orf21
gene id: 61622:C21H18orf21
uniprot id: A0A2K6NSB9
names: Similarity
messages: Belongs to the UPF0711 family.

61622:LY6G5C
gene id: 61622:LY6G5C
uniprot id: A0A2K6NHU5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Forms oligomers.
messages: May have a role in hematopoietic cell differentiation.
messages: Secreted

61622:ELP4
gene id: 61622:ELP4
uniprot id: A0A2K6NN70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

61622:IMPA1
gene id: 61622:IMPA1
uniprot id: A0A2K6ND23
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

61622:KCNG4
gene id: 61622:KCNG4
uniprot id: A0A2K6PDW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:BARHL2
gene id: 61622:BARHL2
uniprot id: A0A2K6RM96
names: Subcellular Location Annotation
messages: Nucleus

61622:SLC39A4
gene id: 61622:SLC39A4
uniprot id: A0A2K6PGN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

61622:ATG4A
gene id: 61622:ATG4A
uniprot id: A0A2K6RFB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

61622:LOC104658933
gene id: 61622:LOC104658933
uniprot id: A0A2K6NPR3
uniprot id: A0A2K6NPR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

61622:PLAUR
gene id: 61622:PLAUR
uniprot id: A0A2K6RY05
names: Function
names: Subcellular Location Annotation
messages: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
messages: Cell membrane
messages: Membrane
messages: invadopodium membrane

61622:TMEM86A
gene id: 61622:TMEM86A
uniprot id: A0A2K6QS61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

61622:NFIC
gene id: 61622:NFIC
uniprot id: A0A2K6RQL1
uniprot id: A0A2K6RQN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

61622:SIVA1
gene id: 61622:SIVA1
uniprot id: A0A2K6P267
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus
messages: Phosphorylated by ABL2/ARG in response to oxidative stress.

61622:RBP1
gene id: 61622:RBP1
uniprot id: A0A2K6R0I8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:TMEM123
gene id: 61622:TMEM123
uniprot id: A0A2K6Q1F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

61622:MAX
gene id: 61622:MAX
uniprot id: A0A2K6QVT2
uniprot id: A0A2K6QVV2
names: Similarity
messages: Belongs to the MAX family.

61622:CTSW
gene id: 61622:CTSW
uniprot id: A0A2K6PJK7
names: Similarity
messages: Belongs to the peptidase C1 family.

61622:PDGFRL
gene id: 61622:PDGFRL
uniprot id: A0A2K6PI79
names: Subcellular Location Annotation
names: Subunit
messages: Forms a complex composed of PDGFRL, TNK2 and GRB2.
messages: Secreted

61622:NKX2-2
gene id: 61622:NKX2-2
uniprot id: A0A2K6R2L3
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104659891
gene id: 61622:LOC104659891
uniprot id: A0A2K6P927
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:GPR89A
gene id: 61622:GPR89A
uniprot id: A0A2K6PBR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

61622:LIPC
gene id: 61622:LIPC
uniprot id: A0A2K6PZI4
uniprot id: A0A2K6PZJ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:LOC104678031
gene id: 61622:LOC104678031
uniprot id: A0A2K6QBC8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

61622:YIF1B
gene id: 61622:YIF1B
uniprot id: A0A2K6QKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

61622:PLPP1
gene id: 61622:PLPP1
uniprot id: A0A2K6QVG0
uniprot id: A0A2K6QVH0
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: caveola

61622:RAE1
gene id: 61622:RAE1
uniprot id: A0A2K6RPF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat rae1 family.
messages: spindle pole

61622:OLFM1
gene id: 61622:OLFM1
uniprot id: A0A2K6Q7W9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61622:MMAA
gene id: 61622:MMAA
uniprot id: A0A2K6NWW1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

61622:AMZ1
gene id: 61622:AMZ1
uniprot id: A0A2K6QEX7
names: Function
names: Similarity
messages: Belongs to the peptidase M54 family.
messages: Probable zinc metalloprotease.

61622:DIABLO
gene id: 61622:DIABLO
uniprot id: A0A2K6PIP0
uniprot id: A0A2K6PIP8
names: Subcellular Location Annotation
messages: Mitochondrion

61622:LOC104679448
gene id: 61622:LOC104679448
uniprot id: A0A2K6RP03
names: Subcellular Location Annotation
messages: Secreted

61622:PURB
gene id: 61622:PURB
uniprot id: A0A2K6N729
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

61622:GK2
gene id: 61622:GK2
uniprot id: A0A2K6QHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

61622:SNAP91
gene id: 61622:SNAP91
uniprot id: A0A2K6Q9F7
uniprot id: A0A2K6Q9H3
uniprot id: A0A2K6Q9I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PICALM/SNAP91 family.
messages: Membrane

61622:MSMB
gene id: 61622:MSMB
uniprot id: A0A2K6QUF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

61622:LMNB1
gene id: 61622:LMNB1
uniprot id: A0A2K6QP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

61622:CLIC4
gene id: 61622:CLIC4
uniprot id: A0A2K6NGR9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

61622:TMEM214
gene id: 61622:TMEM214
uniprot id: A0A2K6NVA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:MED4
gene id: 61622:MED4
uniprot id: A0A2K6NNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:ILVBL
gene id: 61622:ILVBL
uniprot id: A0A2K6RXL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPP enzyme family.
messages: Membrane

61622:URM1
gene id: 61622:URM1
uniprot id: A0A2K6QLN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
messages: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
messages: Cytoplasm

61622:VPS28
gene id: 61622:VPS28
uniprot id: A0A2K6QG17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.
messages: Endosome membrane
messages: Membrane

61622:DR1
gene id: 61622:DR1
uniprot id: A0A2K6Q1A2
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

61622:DSC3
gene id: 61622:DSC3
uniprot id: A0A2K6PU70
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

61622:SPRR2G
gene id: 61622:SPRR2G
uniprot id: A0A2K6N9E2
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61622:CRK
gene id: 61622:CRK
uniprot id: A0A2K6Q388
names: Similarity
messages: Belongs to the CRK family.

61622:CA3
gene id: 61622:CA3
uniprot id: A0A2K6N817
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

61622:ZC3HC1
gene id: 61622:ZC3HC1
uniprot id: A0A2K6R719
names: Subcellular Location Annotation
messages: Nucleus

61622:LOC104666513
gene id: 61622:LOC104666513
uniprot id: A0A2K6RVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:STXBP3
gene id: 61622:STXBP3
uniprot id: A0A2K6P6B2
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

61622:HOXA10
gene id: 61622:HOXA10
uniprot id: A0A2K6Q4U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:LOC104654619
gene id: 61622:LOC104654619
uniprot id: A0A2K6NFE8
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:CEP290
gene id: 61622:CEP290
uniprot id: A0A2K6NIP1
names: Subcellular Location Annotation
messages: cilium basal body

61622:GTDC1
gene id: 61622:GTDC1
uniprot id: A0A2K6PI54
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

61622:CLCN4
gene id: 61622:CLCN4
uniprot id: A0A2K6NR51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

61622:SLC13A4
gene id: 61622:SLC13A4
uniprot id: A0A2K6RBC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

61622:CXCL11
gene id: 61622:CXCL11
uniprot id: A0A2K6QVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:MRPS30
gene id: 61622:MRPS30
uniprot id: A0A2K6PS38
names: Subcellular Location Annotation
messages: Mitochondrion

61622:TMEM53
gene id: 61622:TMEM53
uniprot id: A0A2K6PKR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM53 family.
messages: Membrane
messages: Nucleus outer membrane

61622:TES
gene id: 61622:TES
uniprot id: A0A2K6NJL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: focal adhesion

61622:SPHKAP
gene id: 61622:SPHKAP
uniprot id: A0A2K6PLY2
uniprot id: A0A2K6PM06
names: Similarity
messages: Belongs to the AKAP110 family.

61622:NR0B1
gene id: 61622:NR0B1
uniprot id: A0A2K6Q884
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.

61622:GRB14
gene id: 61622:GRB14
uniprot id: A0A2K6R614
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

61622:INSL3
gene id: 61622:INSL3
uniprot id: A0A2K6R366
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

61622:IRF2BP1
gene id: 61622:IRF2BP1
uniprot id: A0A2K6NPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

61622:LOC104654235
gene id: 61622:LOC104654235
uniprot id: A0A2K6NXX5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:LOC104674017
gene id: 61622:LOC104674017
uniprot id: A0A2K6NFQ1
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

61622:SCG5
gene id: 61622:SCG5
uniprot id: A0A2K6R0P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
messages: Belongs to the 7B2 family.
messages: Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.
messages: Secreted

61622:PMM2
gene id: 61622:PMM2
uniprot id: A0A2K6R3E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

61622:SF3B3
gene id: 61622:SF3B3
uniprot id: A0A2K6RX73
names: Subcellular Location Annotation
messages: Nucleus

61622:C12H19orf54
gene id: 61622:C12H19orf54
uniprot id: A0A2K6P4K7
names: Similarity
messages: Belongs to the UPF0692 family.

61622:RNF182
gene id: 61622:RNF182
uniprot id: A0A2K6NP84
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

61622:ITGA4
gene id: 61622:ITGA4
uniprot id: A0A2K6NH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:NDUFAF4
gene id: 61622:NDUFAF4
uniprot id: A0A2K6PWU4
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

61622:LOC104657697
gene id: 61622:LOC104657697
uniprot id: A0A2K6QFA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:LOC104672982
gene id: 61622:LOC104672982
uniprot id: A0A2K6RBK3
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

61622:SLC39A14
gene id: 61622:SLC39A14
uniprot id: A0A2K6PF71
uniprot id: A0A2K6PFC3
names: Subcellular Location Annotation
messages: Membrane

61622:SLC26A5
gene id: 61622:SLC26A5
uniprot id: A0A2K6PC41
uniprot id: A0A2K6PC93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Cell membrane
messages: Membrane
messages: Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ.

61622:ADD1
gene id: 61622:ADD1
uniprot id: A0A2K6QM38
uniprot id: A0A2K6QM50
uniprot id: A0A2K6QM51
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

61622:ICAM4
gene id: 61622:ICAM4
uniprot id: A0A2K6NY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

61622:HSCB
gene id: 61622:HSCB
uniprot id: A0A2K6R0X8
names: Similarity
messages: Belongs to the HscB family.

61622:CCN5
gene id: 61622:CCN5
uniprot id: A0A2K6P662
names: Similarity
messages: Belongs to the CCN family.

61622:FAM110B
gene id: 61622:FAM110B
uniprot id: A0A2K6NRR1
names: Similarity
messages: Belongs to the FAM110 family.

61622:LOC104661579
gene id: 61622:LOC104661579
uniprot id: A0A2K6NYI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:ACMSD
gene id: 61622:ACMSD
uniprot id: A0A2K6PIS8
uniprot id: A0A2K6PIU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
messages: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
messages: Monomer.

61622:PLPBP
gene id: 61622:PLPBP
uniprot id: A0A2K6NPJ9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

61622:LOC104655794
gene id: 61622:LOC104655794
uniprot id: A0A2K6QRX9
names: Subcellular Location Annotation
messages: Nucleus

61622:ZSCAN22
gene id: 61622:ZSCAN22
uniprot id: A0A2K6P1Z4
names: Subcellular Location Annotation
messages: Nucleus

61622:TAZ
gene id: 61622:TAZ
uniprot id: A0A2K6QI08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
messages: Associates with multiple protein complexes.
messages: Belongs to the taffazin family.
messages: Mitochondrion inner membrane
messages: Mitochondrion outer membrane

61622:MBOAT2
gene id: 61622:MBOAT2
uniprot id: A0A2K6RUP5
names: Subcellular Location Annotation
messages: Membrane

61622:MB21D2
gene id: 61622:MB21D2
uniprot id: A0A2K6PR29
names: Similarity
messages: Belongs to the mab-21 family.

61622:AQP1
gene id: 61622:AQP1
uniprot id: A0A2K6N818
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
messages: Membrane

61622:RC3H1
gene id: 61622:RC3H1
uniprot id: A0A2K6QA15
names: Subcellular Location Annotation
messages: P-body

61622:DMAP1
gene id: 61622:DMAP1
uniprot id: A0A2K6Q096
names: Subcellular Location Annotation
messages: Nucleus

61622:TIPRL
gene id: 61622:TIPRL
uniprot id: A0A2K6NXG1
uniprot id: A0A2K6NXG2
names: Similarity
messages: Belongs to the TIP41 family.

61622:TAF12
gene id: 61622:TAF12
uniprot id: A0A2K6NRW6
uniprot id: A0A2K6NRX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

61622:LOC104676095
gene id: 61622:LOC104676095
uniprot id: A0A2K6NW88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

61622:BCCIP
gene id: 61622:BCCIP
uniprot id: A0A2K6PBQ2
uniprot id: A0A2K6PBU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
messages: Nucleus
messages: spindle pole

61622:SUMF1
gene id: 61622:SUMF1
uniprot id: A0A2K6R269
uniprot id: A0A2K6R298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

61622:NDUFV1
gene id: 61622:NDUFV1
uniprot id: A0A2K6QG60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 51 kDa subunit family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion inner membrane

61622:MYBBP1A
gene id: 61622:MYBBP1A
uniprot id: A0A2K6QSP4
names: Similarity
messages: Belongs to the MYBBP1A family.

61622:RNMT
gene id: 61622:RNMT
uniprot id: A0A2K6QXR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

61622:VAC14
gene id: 61622:VAC14
uniprot id: A0A2K6RIM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VAC14 family.
messages: Endosome membrane
messages: Microsome membrane

61622:LOC104669437
gene id: 61622:LOC104669437
uniprot id: A0A2K6NGY1
names: Subcellular Location Annotation
messages: Membrane

61622:XCR1
gene id: 61622:XCR1
uniprot id: A0A2K6NAK8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:SCP2
gene id: 61622:SCP2
uniprot id: A0A2K6NQX1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion
messages: Peroxisome

61622:LIPT1
gene id: 61622:LIPT1
uniprot id: A0A2K6NGV4
names: Similarity
messages: Belongs to the LplA family.

61622:IPO8
gene id: 61622:IPO8
uniprot id: A0A2K6Q626
names: Subcellular Location Annotation
messages: Cytoplasm

61622:PRPF38A
gene id: 61622:PRPF38A
uniprot id: A0A2K6PLF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

61622:CBX8
gene id: 61622:CBX8
uniprot id: A0A2K6QBY1
names: Subcellular Location Annotation
messages: Nucleus

61622:FERMT3
gene id: 61622:FERMT3
uniprot id: A0A2K6NJJ1
names: Similarity
messages: Belongs to the kindlin family.

61622:MAP2K6
gene id: 61622:MAP2K6
uniprot id: A0A2K6P648
uniprot id: A0A2K6P656
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:CLTA
gene id: 61622:CLTA
uniprot id: A0A2K6P794
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

61622:LOC104663230
gene id: 61622:LOC104663230
uniprot id: A0A2K6NAY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

61622:GRIK1
gene id: 61622:GRIK1
uniprot id: A0A2K6QIA3
uniprot id: A0A2K6QIA7
uniprot id: A0A2K6QIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

61622:RSPO2
gene id: 61622:RSPO2
uniprot id: A0A2K6NNT9
uniprot id: A0A2K6NNX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-spondin family.
messages: Secreted

61622:FAR2
gene id: 61622:FAR2
uniprot id: A0A2K6RDC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

61622:MFN1
gene id: 61622:MFN1
uniprot id: A0A2K6NHN8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

61622:FGF6
gene id: 61622:FGF6
uniprot id: A0A2K6QUT8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:P4HA3
gene id: 61622:P4HA3
uniprot id: A0A2K6P8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

61622:COQ5
gene id: 61622:COQ5
uniprot id: A0A2K6QJJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

61622:PFDN4
gene id: 61622:PFDN4
uniprot id: A0A2K6PBH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

61622:KCNA10
gene id: 61622:KCNA10
uniprot id: A0A2K6NHJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CCN1
gene id: 61622:CCN1
uniprot id: A0A2K6NXR4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:TNFRSF4
gene id: 61622:TNFRSF4
uniprot id: A0A2K6RD68
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SUB1
gene id: 61622:SUB1
uniprot id: A0A2K6QY80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

61622:MRPL50
gene id: 61622:MRPL50
uniprot id: A0A2K6Q8R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

61622:B3GALT5
gene id: 61622:B3GALT5
uniprot id: A0A2K6NYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:RAD17
gene id: 61622:RAD17
uniprot id: A0A2K6P5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

61622:LDB1
gene id: 61622:LDB1
uniprot id: A0A2K6PSQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDB family.
messages: Nucleus

61622:KCNN4
gene id: 61622:KCNN4
uniprot id: A0A2K6PF20
names: Subcellular Location Annotation
messages: Membrane

61622:KRT6A
gene id: 61622:KRT6A
uniprot id: A0A2K6PY09
names: Similarity
messages: Belongs to the intermediate filament family.

61622:FGF21
gene id: 61622:FGF21
uniprot id: A0A2K6QPG0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:MAN1A1
gene id: 61622:MAN1A1
uniprot id: A0A2K6P217
uniprot id: A0A2K6P222
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:MAU2
gene id: 61622:MAU2
uniprot id: A0A2K6PKK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC4/mau-2 family.
messages: nucleoplasm

61622:SLC17A8
gene id: 61622:SLC17A8
uniprot id: A0A2K6PXS7
uniprot id: A0A2K6PXT5
names: Subcellular Location Annotation
messages: Membrane

61622:IBSP
gene id: 61622:IBSP
uniprot id: A0A2K6Q4M6
names: Function
names: Subcellular Location Annotation
messages: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
messages: Secreted

61622:CALCR
gene id: 61622:CALCR
uniprot id: A0A2K6RNJ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Interacts with GPRASP2.
messages: Membrane

61622:CLDN14
gene id: 61622:CLDN14
uniprot id: A0A2K6NEN9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:TMPRSS7
gene id: 61622:TMPRSS7
uniprot id: A0A2K6PPT7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104667825
gene id: 61622:LOC104667825
uniprot id: A0A2K6NIU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

61622:LCN2
gene id: 61622:LCN2
uniprot id: A0A2K6QP69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

61622:C3
gene id: 61622:C3
uniprot id: A0A2K6RMX8
names: Function
names: Subcellular Location Annotation
messages: Acts as a chemoattractant for neutrophils in chronic inflammation.
messages: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
messages: Secreted

61622:DDB2
gene id: 61622:DDB2
uniprot id: A0A2K6RV49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: Nucleus

61622:PRMT5
gene id: 61622:PRMT5
uniprot id: A0A2K6NY20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Nucleus

61622:ESYT1
gene id: 61622:ESYT1
uniprot id: A0A2K6Q175
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CALHM3
gene id: 61622:CALHM3
uniprot id: A0A2K6NE09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

61622:LDAH
gene id: 61622:LDAH
uniprot id: A0A2K6RDL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

61622:POT1
gene id: 61622:POT1
uniprot id: A0A2K6RUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

61622:CTSB
gene id: 61622:CTSB
uniprot id: A0A2K6PNV7
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase C1 family.
messages: Lysosome

61622:DIPK2A
gene id: 61622:DIPK2A
uniprot id: A0A2K6NGP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

61622:RPS14
gene id: 61622:RPS14
uniprot id: A0A2K6NTV6
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

61622:GINS2
gene id: 61622:GINS2
uniprot id: A0A2K6QXS2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

61622:ACTA2
gene id: 61622:ACTA2
uniprot id: A0A2K6PUD3
names: Similarity
messages: Belongs to the actin family.

61622:UTP15
gene id: 61622:UTP15
uniprot id: A0A2K6PX25
names: Subcellular Location Annotation
messages: nucleolus

61622:EMC2
gene id: 61622:EMC2
uniprot id: A0A2K6QHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

61622:ITPR2
gene id: 61622:ITPR2
uniprot id: A0A2K6Q332
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

61622:VEGFC
gene id: 61622:VEGFC
uniprot id: A0A2K6P1E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

61622:PPFIBP2
gene id: 61622:PPFIBP2
uniprot id: A0A2K6P8U5
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

61622:ALKBH1
gene id: 61622:ALKBH1
uniprot id: A0A2K6R6J4
names: Similarity
messages: Belongs to the alkB family.

61622:HACL1
gene id: 61622:HACL1
uniprot id: A0A2K6PJ26
uniprot id: A0A2K6PJ33
names: Similarity
messages: Belongs to the TPP enzyme family.

61622:TAS2R5
gene id: 61622:TAS2R5
uniprot id: A0A2K6NKA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

61622:PLBD1
gene id: 61622:PLBD1
uniprot id: A0A2K6QW87
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

61622:APIP
gene id: 61622:APIP
uniprot id: A0A2K6RRS0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. Adducin subfamily.
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
messages: Cytoplasm
messages: Homotetramer. Interacts with APAF1. May interact with CASP1.

61622:ACP5
gene id: 61622:ACP5
uniprot id: A0A2K6PV76
names: Cofactor
messages: Binds 2 iron ions per subunit.

61622:HOXD9
gene id: 61622:HOXD9
uniprot id: A0A2K6PHU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:PIGB
gene id: 61622:PIGB
uniprot id: A0A2K6RD79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

61622:MAL
gene id: 61622:MAL
uniprot id: A0A2K6Q152
names: Subcellular Location Annotation
messages: Membrane

61622:TERF2IP
gene id: 61622:TERF2IP
uniprot id: A0A2K6QY86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Nucleus
messages: telomere

61622:GAST
gene id: 61622:GAST
uniprot id: A0A2K6RGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

61622:LOC104671155
gene id: 61622:LOC104671155
uniprot id: A0A2K6Q960
uniprot id: A0A2K6Q966
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MRPL40
gene id: 61622:MRPL40
uniprot id: A0A2K6RJN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

61622:SLC16A13
gene id: 61622:SLC16A13
uniprot id: A0A2K6PA03
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104677678
gene id: 61622:LOC104677678
uniprot id: A0A2K6NBG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:PUS10
gene id: 61622:PUS10
uniprot id: A0A2K6QUX8
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

61622:ARL4D
gene id: 61622:ARL4D
uniprot id: A0A2K6NFE5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

61622:LOC104679876
gene id: 61622:LOC104679876
uniprot id: A0A2K6QHM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

61622:CPA3
gene id: 61622:CPA3
uniprot id: A0A2K6PG60
names: Similarity
messages: Belongs to the peptidase M14 family.

61622:COQ8B
gene id: 61622:COQ8B
uniprot id: A0A2K6QWI7
uniprot id: A0A2K6QWN3
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

61622:PHB
gene id: 61622:PHB
uniprot id: A0A2K6QMK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

61622:APOM
gene id: 61622:APOM
uniprot id: A0A2K6PNZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

61622:GALNT18
gene id: 61622:GALNT18
uniprot id: A0A2K6R026
uniprot id: A0A2K6R064
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:SLC5A12
gene id: 61622:SLC5A12
uniprot id: A0A2K6NH94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:LOC104656462
gene id: 61622:LOC104656462
uniprot id: A0A2K6Q6D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

61622:TMEM33
gene id: 61622:TMEM33
uniprot id: A0A2K6NFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

61622:PRPS2
gene id: 61622:PRPS2
uniprot id: A0A2K6P908
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family.
messages: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
messages: Homodimer. The active form is probably a hexamer composed of 3 homodimers.

61622:LMOD2
gene id: 61622:LMOD2
uniprot id: A0A2K6NAU2
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

61622:EPC2
gene id: 61622:EPC2
uniprot id: A0A2K6PAU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

61622:GOLT1A
gene id: 61622:GOLT1A
uniprot id: A0A2K6NX95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

61622:HPCAL4
gene id: 61622:HPCAL4
uniprot id: A0A2K6QSY2
names: Function
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

61622:ZDHHC13
gene id: 61622:ZDHHC13
uniprot id: A0A2K6NZ47
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:GRM2
gene id: 61622:GRM2
uniprot id: A0A2K6RB27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

61622:AWAT1
gene id: 61622:AWAT1
uniprot id: A0A2K6NW39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane

61622:MYD88
gene id: 61622:MYD88
uniprot id: A0A2K6NXL8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
messages: Cytoplasm
messages: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.

61622:CHST7
gene id: 61622:CHST7
uniprot id: A0A2K6NC88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

61622:STX18
gene id: 61622:STX18
uniprot id: A0A2K6REW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

61622:TIMP4
gene id: 61622:TIMP4
uniprot id: A0A2K6RGI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease inhibitor I35 (TIMP) family.
messages: Secreted

61622:MTG1
gene id: 61622:MTG1
uniprot id: A0A2K6PHF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Mitochondrion inner membrane
messages: Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.

61622:RHPN2
gene id: 61622:RHPN2
uniprot id: A0A2K6NAH3
names: Similarity
messages: Belongs to the RHPN family.

61622:ADAM33
gene id: 61622:ADAM33
uniprot id: A0A2K6N779
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TLR7
gene id: 61622:TLR7
uniprot id: A0A2K6NIS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

61622:GEM
gene id: 61622:GEM
uniprot id: A0A2K6RTM3
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

61622:IFT20
gene id: 61622:IFT20
uniprot id: A0A2K6R029
uniprot id: A0A2K6R082
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

61622:SLC12A8
gene id: 61622:SLC12A8
uniprot id: A0A2K6RVU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

61622:MLEC
gene id: 61622:MLEC
uniprot id: A0A2K6NQZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CRYBB2
gene id: 61622:CRYBB2
uniprot id: A0A2K6RG08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

61622:OAT
gene id: 61622:OAT
uniprot id: A0A2K6PG54
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

61622:SCNN1B
gene id: 61622:SCNN1B
uniprot id: A0A2K6N8C0
names: Subcellular Location Annotation
messages: Membrane

61622:COLGALT2
gene id: 61622:COLGALT2
uniprot id: A0A2K6QCG4
names: Similarity
messages: Belongs to the glycosyltransferase 25 family.

61622:NSUN2
gene id: 61622:NSUN2
uniprot id: A0A2K6Q227
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

61622:AASDH
gene id: 61622:AASDH
uniprot id: A0A2K6N748
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

61622:DUS3L
gene id: 61622:DUS3L
uniprot id: A0A2K6QCP9
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

61622:SPRTN
gene id: 61622:SPRTN
uniprot id: A0A2K6RIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

61622:LOC104667781
gene id: 61622:LOC104667781
uniprot id: A0A2K6P4M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:CRMP1
gene id: 61622:CRMP1
uniprot id: A0A2K6P176
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

61622:GPX7
gene id: 61622:GPX7
uniprot id: A0A2K6RT75
names: Similarity
messages: Belongs to the glutathione peroxidase family.

61622:LOC104680836
gene id: 61622:LOC104680836
uniprot id: A0A2K6NUU0
names: Similarity
messages: Belongs to the histone H3 family.

61622:KLC1
gene id: 61622:KLC1
uniprot id: A0A2K6PZH1
uniprot id: A0A2K6PZI6
uniprot id: A0A2K6PZI7
uniprot id: A0A2K6PZJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

61622:KCNH3
gene id: 61622:KCNH3
uniprot id: A0A2K6NVK0
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

61622:HOXD12
gene id: 61622:HOXD12
uniprot id: A0A2K6RFY7
names: Subcellular Location Annotation
messages: Nucleus

61622:IFNGR1
gene id: 61622:IFNGR1
uniprot id: A0A2K6Q117
names: Similarity
messages: Belongs to the type II cytokine receptor family.

61622:SLCO1A2
gene id: 61622:SLCO1A2
uniprot id: A0A2K6PZQ5
uniprot id: A0A2K6PZR7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:SENP3
gene id: 61622:SENP3
uniprot id: A0A2K6QC50
uniprot id: A0A2K6QC58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

61622:ALDH2
gene id: 61622:ALDH2
uniprot id: A0A2K6NRB9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

61622:KCNG1
gene id: 61622:KCNG1
uniprot id: A0A2K6Q1W8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:CHRNE
gene id: 61622:CHRNE
uniprot id: A0A2K6QUR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:MASP2
gene id: 61622:MASP2
uniprot id: A0A2K6P3M1
uniprot id: A0A2K6P3P7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CLDN2
gene id: 61622:CLDN2
uniprot id: A0A2K6NB52
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

61622:KRT14
gene id: 61622:KRT14
uniprot id: A0A2K6Q1E0
names: Similarity
messages: Belongs to the intermediate filament family.

61622:DUSP7
gene id: 61622:DUSP7
uniprot id: A0A2K6PA83
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

61622:NQO2
gene id: 61622:NQO2
uniprot id: A0A2K6PI91
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

61622:LOC104676747
gene id: 61622:LOC104676747
uniprot id: A0A2K6RET2
uniprot id: A0A2K6RTM6
names: Similarity
messages: Belongs to the GroES chaperonin family.
messages: Belongs to the MOB1/phocein family.

61622:SLITRK6
gene id: 61622:SLITRK6
uniprot id: A0A2K6NIV7
names: Similarity
messages: Belongs to the SLITRK family.

61622:RENBP
gene id: 61622:RENBP
uniprot id: A0A2K6PV22
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

61622:GK5
gene id: 61622:GK5
uniprot id: A0A2K6NYM2
names: Similarity
messages: Belongs to the FGGY kinase family.

61622:GPRC5C
gene id: 61622:GPRC5C
uniprot id: A0A2K6PVF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:IFRD1
gene id: 61622:IFRD1
uniprot id: A0A2K6RE12
names: Similarity
messages: Belongs to the IFRD family.

61622:GHRL
gene id: 61622:GHRL
uniprot id: A0A2K6NEF0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the motilin family.
messages: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.
messages: O-octanoylation is essential for ghrelin activity.
messages: Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
messages: Secreted

61622:LOC104676337
gene id: 61622:LOC104676337
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:LOC104670912
gene id: 61622:LOC104670912
uniprot id: A0A2K6NP58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:PPIC
gene id: 61622:PPIC
uniprot id: A0A2K6P8K3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:BBS2
gene id: 61622:BBS2
uniprot id: A0A2K6QUZ0
uniprot id: A0A2K6QUZ4
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

61622:IST1
gene id: 61622:IST1
uniprot id: A0A2K6RCH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

61622:RPRD1A
gene id: 61622:RPRD1A
uniprot id: A0A2K6QX95
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

61622:ST3GAL1
gene id: 61622:ST3GAL1
uniprot id: A0A2K6P051
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:GUCA2B
gene id: 61622:GUCA2B
uniprot id: A0A2K6PHR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

61622:UBXN1
gene id: 61622:UBXN1
uniprot id: A0A2K6R151
uniprot id: A0A2K6R152
names: Subcellular Location Annotation
messages: Cytoplasm

61622:LOC104673241
gene id: 61622:LOC104673241
uniprot id: A0A2K6P4U2
uniprot id: A0A2K6P4U7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

61622:CHMP1A
gene id: 61622:CHMP1A
uniprot id: A0A2K6NW64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

61622:LOC104672408
gene id: 61622:LOC104672408
uniprot id: A0A2K6P927
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:TMEM63B
gene id: 61622:TMEM63B
uniprot id: A0A2K6PPT3
uniprot id: A0A2K6PPT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

61622:SLC25A39
gene id: 61622:SLC25A39
uniprot id: A0A2K6PTU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

61622:UBIAD1
gene id: 61622:UBIAD1
uniprot id: A0A2K6NYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

61622:TMEM161A
gene id: 61622:TMEM161A
uniprot id: A0A2K6NPG7
uniprot id: A0A2K6NPH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

61622:MPC2
gene id: 61622:MPC2
uniprot id: A0A2K6P2N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61622:RPS6KB2
gene id: 61622:RPS6KB2
uniprot id: A0A2K6RQ89
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

61622:KIFBP
gene id: 61622:KIFBP
uniprot id: A0A2K6Q8U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KIF-binding protein family.
messages: cytoskeleton

61622:PRKACB
gene id: 61622:PRKACB
uniprot id: A0A2K6NMP1
uniprot id: A0A2K6NMR8
uniprot id: A0A2K6NMR9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

61622:CHRNB3
gene id: 61622:CHRNB3
uniprot id: A0A2K6QUD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:SLC19A2
gene id: 61622:SLC19A2
uniprot id: A0A2K6REM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

61622:SFT2D1
gene id: 61622:SFT2D1
uniprot id: A0A2K6NKG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

61622:LOC104678659
gene id: 61622:LOC104678659
uniprot id: A0A2K6NTV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

61622:SLC11A2
gene id: 61622:SLC11A2
uniprot id: A0A2K6R7M6
names: Similarity
messages: Belongs to the NRAMP family.

61622:SNX19
gene id: 61622:SNX19
uniprot id: A0A2K6NH18
names: Similarity
messages: Belongs to the sorting nexin family.

61622:YPEL5
gene id: 61622:YPEL5
uniprot id: A0A2K6NVL1
names: Similarity
messages: Belongs to the yippee family.

61622:VIP
gene id: 61622:VIP
uniprot id: A0A2K6Q148
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted
messages: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.

61622:CNEP1R1
gene id: 61622:CNEP1R1
uniprot id: A0A2K6Q1K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

61622:ILDR2
gene id: 61622:ILDR2
uniprot id: A0A2K6R2P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

61622:TNFRSF10D
gene id: 61622:TNFRSF10D
uniprot id: A0A2K6QK89
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:PRRT1
gene id: 61622:PRRT1
uniprot id: A0A2K6NM23
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:CCDC85A
gene id: 61622:CCDC85A
uniprot id: A0A2K6NPF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

61622:DGAT1
gene id: 61622:DGAT1
uniprot id: A0A2K6NFA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Homodimer or homotetramer; both forms have similar enzymatic activities.
messages: Membrane

61622:LRP10
gene id: 61622:LRP10
uniprot id: A0A2K6RT82
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:LAMTOR3
gene id: 61622:LAMTOR3
uniprot id: A0A2K6PGS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

61622:DYNLRB2
gene id: 61622:DYNLRB2
uniprot id: A0A2K6PVG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

61622:CNMD
gene id: 61622:CNMD
uniprot id: A0A2K6QRT0
names: Similarity
messages: Belongs to the chondromodulin-1 family.

61622:CDC37
gene id: 61622:CDC37
uniprot id: A0A2K6P6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

61622:CCN3
gene id: 61622:CCN3
uniprot id: A0A2K6PDU0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:SLC39A6
gene id: 61622:SLC39A6
uniprot id: A0A2K6NZQ2
names: Subcellular Location Annotation
messages: Membrane

61622:ZER1
gene id: 61622:ZER1
uniprot id: A0A2K6Q791
names: Similarity
messages: Belongs to the zyg-11 family.

61622:MB
gene id: 61622:MB
uniprot id: A0A2K6NL17
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

61622:TBRG1
gene id: 61622:TBRG1
uniprot id: A0A2K6QMM5
names: Subcellular Location Annotation
messages: Nucleus

61622:ELP6
gene id: 61622:ELP6
uniprot id: A0A2K6QMK3
names: Similarity
messages: Belongs to the ELP6 family.

61622:GJB1
gene id: 61622:GJB1
uniprot id: A0A2K6NE00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

61622:PDCD5
gene id: 61622:PDCD5
uniprot id: A0A2K6QVW2
uniprot id: A0A2K6QW11
names: Similarity
messages: Belongs to the PDCD5 family.

61622:ADPRHL2
gene id: 61622:ADPRHL2
uniprot id: A0A2K6P5D1
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

61622:TBCE
gene id: 61622:TBCE
uniprot id: A0A2K6NEQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

61622:LOC104676970
gene id: 61622:LOC104676970
uniprot id: A0A2K6PNW2
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

61622:GTF2E1
gene id: 61622:GTF2E1
uniprot id: A0A2K6NN34
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

61622:CDH5
gene id: 61622:CDH5
uniprot id: A0A2K6RRI5
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell junction
messages: Cell membrane
messages: Membrane

61622:SERPINE2
gene id: 61622:SERPINE2
uniprot id: A0A2K6QYN7
names: Similarity
messages: Belongs to the serpin family.

61622:SLC7A11
gene id: 61622:SLC7A11
uniprot id: A0A2K6PEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Membrane

61622:PIGL
gene id: 61622:PIGL
uniprot id: A0A2K6PSB7
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

61622:PARP8
gene id: 61622:PARP8
uniprot id: A0A2K6NS56
names: Similarity
messages: Belongs to the ARTD/PARP family.

61622:TBC1D24
gene id: 61622:TBC1D24
uniprot id: A0A2K6QYR3
uniprot id: A0A2K6QYS8
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

61622:ABL1
gene id: 61622:ABL1
uniprot id: A0A2K6PIM2
uniprot id: A0A2K6PIP4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:GNB4
gene id: 61622:GNB4
uniprot id: A0A2K6R4Z3
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

61622:PRICKLE1
gene id: 61622:PRICKLE1
uniprot id: A0A2K6QXE8
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

61622:HOGA1
gene id: 61622:HOGA1
uniprot id: A0A2K6R179
uniprot id: A0A2K6R185
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

61622:SCN3B
gene id: 61622:SCN3B
uniprot id: A0A2K6R1E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

61622:MEIG1
gene id: 61622:MEIG1
uniprot id: A0A2K6QNN1
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

61622:B3GALNT2
gene id: 61622:B3GALNT2
uniprot id: A0A2K6Q9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:AMIGO1
gene id: 61622:AMIGO1
uniprot id: A0A2K6NL35
names: Similarity
messages: Belongs to the immunoglobulin superfamily. AMIGO family.

61622:LOC104672362
gene id: 61622:LOC104672362
uniprot id: A0A2K6NHC6
names: Similarity
messages: Belongs to the ubiquitin family.

61622:PRLR
gene id: 61622:PRLR
uniprot id: A0A2K6NVZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

61622:MCL1
gene id: 61622:MCL1
uniprot id: A0A2K6PPI3
uniprot id: A0A2K6PPK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

61622:OLFML3
gene id: 61622:OLFML3
uniprot id: A0A2K6QU02
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OLFML3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:F2
gene id: 61622:F2
uniprot id: A0A2K6QIT6
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

61622:NPY1R
gene id: 61622:NPY1R
uniprot id: A0A2K6Q250
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:MFSD11
gene id: 61622:MFSD11
uniprot id: A0A2K6QV40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

61622:LOC104680420
gene id: 61622:LOC104680420
uniprot id: A0A2K6PQ65
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

61622:TNFAIP1
gene id: 61622:TNFAIP1
uniprot id: A0A2K6Q2K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BACURD family.
messages: Cell membrane

61622:DMRTC1
gene id: 61622:DMRTC1
uniprot id: A0A2K6P4W0
names: Similarity
messages: Belongs to the DMRT family.

61622:MRPL12
gene id: 61622:MRPL12
uniprot id: A0A2K6NE02
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

61622:TEAD2
gene id: 61622:TEAD2
uniprot id: A0A2K6QTV5
uniprot id: A0A2K6QTX9
names: Subcellular Location Annotation
messages: Nucleus

61622:USP13
gene id: 61622:USP13
uniprot id: A0A2K6RTY3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:ST3GAL3
gene id: 61622:ST3GAL3
uniprot id: A0A2K6R9U1
uniprot id: A0A2K6R9X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:RNASEH2A
gene id: 61622:RNASEH2A
uniprot id: A0A2K6RJF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

61622:EIF3M
gene id: 61622:EIF3M
uniprot id: A0A2K6R6B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

61622:PHACTR4
gene id: 61622:PHACTR4
uniprot id: A0A2K6R3I7
uniprot id: A0A2K6R3I9
uniprot id: A0A2K6R3K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.
messages: lamellipodium

61622:TNNT2
gene id: 61622:TNNT2
uniprot id: A0A2K6NDB0
uniprot id: A0A2K6NDC4
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

61622:MGST2
gene id: 61622:MGST2
uniprot id: A0A2K6NUP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:CSF3
gene id: 61622:CSF3
uniprot id: A0A2K6P8H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
messages: Secreted

61622:TMEM144
gene id: 61622:TMEM144
uniprot id: A0A2K6RCD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM144 family.
messages: Membrane

61622:KIAA1191
gene id: 61622:KIAA1191
uniprot id: A0A2K6PEZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

61622:VIPR1
gene id: 61622:VIPR1
uniprot id: A0A2K6NW78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

61622:ACTR10
gene id: 61622:ACTR10
uniprot id: A0A2K6NX04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

61622:RIMKLA
gene id: 61622:RIMKLA
uniprot id: A0A2K6P0A7
names: Similarity
messages: Belongs to the RimK family.

61622:ITGB4
gene id: 61622:ITGB4
uniprot id: A0A2K6N7I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61622:OSBPL3
gene id: 61622:OSBPL3
uniprot id: A0A2K6NPI3
names: Similarity
messages: Belongs to the OSBP family.

61622:BRMS1
gene id: 61622:BRMS1
uniprot id: A0A2K6QBP5
names: Subcellular Location Annotation
messages: Nucleus

61622:POU2F1
gene id: 61622:POU2F1
uniprot id: A0A2K6NE91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

61622:CXCL14
gene id: 61622:CXCL14
uniprot id: A0A2K6NS67
names: Subcellular Location Annotation
messages: Secreted

61622:EIF4EBP1
gene id: 61622:EIF4EBP1
uniprot id: A0A2K6RWW4
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

61622:KIF27
gene id: 61622:KIF27
uniprot id: A0A2K6NWS9
uniprot id: A0A2K6NWV1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:SLC14A1
gene id: 61622:SLC14A1
uniprot id: A0A2K6PU07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

61622:EMC1
gene id: 61622:EMC1
uniprot id: A0A2K6Q6D8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:SLC35D1
gene id: 61622:SLC35D1
uniprot id: A0A2K6QDI5
names: Subcellular Location Annotation
messages: Membrane

61622:PTPRB
gene id: 61622:PTPRB
uniprot id: A0A2K6NEY8
uniprot id: A0A2K6NEZ1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

61622:USP27X
gene id: 61622:USP27X
uniprot id: A0A2K6QE20
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

61622:B3GAT2
gene id: 61622:B3GAT2
uniprot id: A0A2K6NK52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:LOC104682518
gene id: 61622:LOC104682518
uniprot id: A0A2K6N7F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

61622:ZEB1
gene id: 61622:ZEB1
uniprot id: A0A2K6R8B9
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

61622:APOH
gene id: 61622:APOH
uniprot id: A0A2K6QY04
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:TFRC
gene id: 61622:TFRC
uniprot id: A0A2K6NVI2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

61622:OTUB2
gene id: 61622:OTUB2
uniprot id: A0A2K6PMQ6
names: Similarity
messages: Belongs to the peptidase C65 family.

61622:MOB3C
gene id: 61622:MOB3C
uniprot id: A0A2K6QJ27
names: Similarity
messages: Belongs to the MOB1/phocein family.

61622:TOX4
gene id: 61622:TOX4
uniprot id: A0A2K6QIS7
names: Subcellular Location Annotation
messages: Nucleus

61622:RAB4B
gene id: 61622:RAB4B
uniprot id: A0A2K6RGH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

61622:AHR
gene id: 61622:AHR
uniprot id: A0A2K6PJY6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:DKK1
gene id: 61622:DKK1
uniprot id: A0A2K6QDM0
names: Similarity
messages: Belongs to the dickkopf family.

61622:IFNB1
gene id: 61622:IFNB1
uniprot id: A0A2K6N8V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

61622:PROS1
gene id: 61622:PROS1
uniprot id: A0A2K6P871
names: Caution
names: Function
messages: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:OCIAD1
gene id: 61622:OCIAD1
uniprot id: A0A2K6PN44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

61622:GPR171
gene id: 61622:GPR171
uniprot id: A0A2K6NIB3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:ORMDL1
gene id: 61622:ORMDL1
uniprot id: A0A2K6QPM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

61622:LIN9
gene id: 61622:LIN9
uniprot id: A0A2K6QWZ3
uniprot id: A0A2K6QX15
names: Similarity
messages: Belongs to the lin-9 family.

61622:CAMK2N1
gene id: 61622:CAMK2N1
uniprot id: A0A2K6PB86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAMK2N family.
messages: Synapse

61622:PAQR6
gene id: 61622:PAQR6
uniprot id: A0A2K6R874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:FZD3
gene id: 61622:FZD3
uniprot id: A0A2K6RBZ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CENPT
gene id: 61622:CENPT
uniprot id: A0A2K6R7J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-T/CNN1 family.
messages: Nucleus
messages: kinetochore

61622:LOC104659463
gene id: 61622:LOC104659463
uniprot id: A0A2K6NIV6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:MFSD6
gene id: 61622:MFSD6
uniprot id: A0A2K6RGF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

61622:LEP
gene id: 61622:LEP
uniprot id: F1AWN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the leptin family.
messages: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by in…
messages: Secreted

61622:PDX1
gene id: 61622:PDX1
uniprot id: A0A2K6QMQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

61622:VPS13C
gene id: 61622:VPS13C
uniprot id: A0A2K6PBZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS13 family.
messages: Lipid droplet

61622:SART1
gene id: 61622:SART1
uniprot id: A0A2K6RU81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

61622:SMARCAD1
gene id: 61622:SMARCAD1
uniprot id: A0A2K6Q2E3
names: Subcellular Location Annotation
messages: Chromosome

61622:TOMM7
gene id: 61622:TOMM7
uniprot id: A0A2K6QS07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

61622:MMD
gene id: 61622:MMD
uniprot id: A0A2K6NWY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

61622:TMEM205
gene id: 61622:TMEM205
uniprot id: A0A2K6QAP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

61622:CAPN1
gene id: 61622:CAPN1
uniprot id: A0A2K6R6K6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

61622:LOC104665273
gene id: 61622:LOC104665273
uniprot id: A0A2K6QRQ6
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:LOC104676156
gene id: 61622:LOC104676156
uniprot id: A0A2K6NYB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lambda interferon family.
messages: Secreted

61622:FAM110A
gene id: 61622:FAM110A
uniprot id: A0A2K6NSI5
names: Similarity
messages: Belongs to the FAM110 family.

61622:ISL2
gene id: 61622:ISL2
uniprot id: A0A2K6RK91
names: Subcellular Location Annotation
messages: Nucleus

61622:RNH1
gene id: 61622:RNH1
uniprot id: A0A2K6N8C2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

61622:MAPRE2
gene id: 61622:MAPRE2
uniprot id: A0A2K6PXA4
uniprot id: A0A2K6PXB8
uniprot id: A0A2K6PXC1
uniprot id: A0A2K6PXC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
messages: cytoskeleton

61622:MLF2
gene id: 61622:MLF2
uniprot id: A0A2K6QMZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

61622:AGPAT3
gene id: 61622:AGPAT3
uniprot id: A0A2K6PAM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:PANX3
gene id: 61622:PANX3
uniprot id: A0A2K6PEF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

61622:MED27
gene id: 61622:MED27
uniprot id: A0A2K6QCG2
uniprot id: A0A2K6QCJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 27 family.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

61622:CLEC16A
gene id: 61622:CLEC16A
uniprot id: A0A2K6RMW2
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

61622:UROD
gene id: 61622:UROD
uniprot id: A0A2K6RB30
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

61622:XIRP2
gene id: 61622:XIRP2
uniprot id: A0A2K6Q5I9
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

61622:GDF3
gene id: 61622:GDF3
uniprot id: A0A2K6PAI3
names: Similarity
messages: Belongs to the TGF-beta family.

61622:LIG1
gene id: 61622:LIG1
uniprot id: A0A2K6QQN7
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

61622:PSMA5
gene id: 61622:PSMA5
uniprot id: A0A2K6QU29
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

61622:CDK5RAP3
gene id: 61622:CDK5RAP3
uniprot id: A0A2K6RQ86
names: Similarity
messages: Belongs to the CDK5RAP3 family.

61622:LOC104673884
gene id: 61622:LOC104673884
uniprot id: A0A2K6QVH2
names: Similarity
messages: Belongs to the MHC class II family.

61622:GIPR
gene id: 61622:GIPR
uniprot id: A0A2K6PCE6
names: Subcellular Location Annotation
messages: Membrane

61622:KAT8
gene id: 61622:KAT8
uniprot id: A0A2K6QLK1
uniprot id: A0A2K6QLK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

61622:PTGES3
gene id: 61622:PTGES3
uniprot id: A0A2K6PSW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p23/wos2 family.
messages: Cytoplasm
messages: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation.
messages: Forms a complex with HSP70, HSP90 and other chaperones.

61622:RPL36AL
gene id: 61622:RPL36AL
uniprot id: A0A2K6N7A0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

61622:TAP2
gene id: 61622:TAP2
uniprot id: A0A2K6PQY9
names: Similarity
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

61622:EVL
gene id: 61622:EVL
uniprot id: A0A2K6RBV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.
messages: lamellipodium
messages: stress fiber

61622:TMEM106A
gene id: 61622:TMEM106A
uniprot id: A0A2K6Q7Q1
names: Similarity
messages: Belongs to the TMEM106 family.

61622:LOC104679773
gene id: 61622:LOC104679773
uniprot id: A0A2K6QGP8
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:MRPS21
gene id: 61622:MRPS21
uniprot id: A0A2K6Q1K3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

61622:XPOT
gene id: 61622:XPOT
uniprot id: A0A2K6QJN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

61622:SLC28A3
gene id: 61622:SLC28A3
uniprot id: A0A2K6NAS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

61622:ATOH7
gene id: 61622:ATOH7
uniprot id: A0A2K6N9K3
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

61622:MKNK1
gene id: 61622:MKNK1
uniprot id: A0A2K6QUM7
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:NCF2
gene id: 61622:NCF2
uniprot id: A0A2K6RL28
names: Similarity
messages: Belongs to the NCF2/NOXA1 family.

61622:CASP4
gene id: 61622:CASP4
uniprot id: A0A2K6Q2V4
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:PFDN2
gene id: 61622:PFDN2
uniprot id: A0A2K6RUA8
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

61622:LOC104654549
gene id: 61622:LOC104654549
uniprot id: A0A2K6P3C7
names: Similarity
messages: Belongs to the intermediate filament family.

61622:RNF112
gene id: 61622:RNF112
uniprot id: A0A2K6Q0P3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

61622:DYNC1I2
gene id: 61622:DYNC1I2
uniprot id: A0A2K6R3Z9
names: Similarity
messages: Belongs to the dynein intermediate chain family.

61622:FN3KRP
gene id: 61622:FN3KRP
uniprot id: A0A2K6RKW6
uniprot id: A0A2K6RKY5
names: Similarity
messages: Belongs to the fructosamine kinase family.

61622:TBX20
gene id: 61622:TBX20
uniprot id: A0A2K6QQJ1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:GRAMD1C
gene id: 61622:GRAMD1C
uniprot id: A0A2K6R420
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:COPA
gene id: 61622:COPA
uniprot id: A0A2K6NDM1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

61622:SPSB4
gene id: 61622:SPSB4
uniprot id: A0A2K6RJL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

61622:SMIM7
gene id: 61622:SMIM7
uniprot id: A0A2K6QGZ1
names: Similarity
messages: Belongs to the SMIM7 family.

61622:MX2
gene id: 61622:MX2
uniprot id: A0A2K6PDB5
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

61622:TEX261
gene id: 61622:TEX261
uniprot id: A0A2K6P471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

61622:LOC104672407
gene id: 61622:LOC104672407
uniprot id: A0A2K6NI12
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:BTN2A1
gene id: 61622:BTN2A1
uniprot id: A0A2K6QQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. BTN/MOG family.
messages: Membrane

61622:ZNF215
gene id: 61622:ZNF215
uniprot id: A0A2K6P8L7
names: Subcellular Location Annotation
messages: Nucleus

61622:CCNA2
gene id: 61622:CCNA2
uniprot id: A0A2K6Q6A5
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

61622:EDEM2
gene id: 61622:EDEM2
uniprot id: A0A2K6PPW6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

61622:CELSR3
gene id: 61622:CELSR3
uniprot id: A0A2K6QE19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

61622:MAP4K1
gene id: 61622:MAP4K1
uniprot id: A0A2K6QQK9
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

61622:FRRS1
gene id: 61622:FRRS1
uniprot id: A0A2K6RVU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

61622:LOC104678511
gene id: 61622:LOC104678511
uniprot id: A0A2K6PN71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

61622:IAH1
gene id: 61622:IAH1
uniprot id: A0A2K6PUW7
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

61622:DPM2
gene id: 61622:DPM2
uniprot id: A0A2K6PX69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

61622:APOC4
gene id: 61622:APOC4
uniprot id: A0A2K6PFU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C4 family.
messages: May participate in lipoprotein metabolism.
messages: Secreted

61622:GCNT3
gene id: 61622:GCNT3
uniprot id: A0A2K6NE50
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

61622:SERPINI1
gene id: 61622:SERPINI1
uniprot id: A0A2K6P4Y2
names: Similarity
messages: Belongs to the serpin family.

61622:TNNT3
gene id: 61622:TNNT3
uniprot id: A0A2K6PNR4
uniprot id: A0A2K6PNV6
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

61622:CUL9
gene id: 61622:CUL9
uniprot id: A0A2K6PZK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

61622:LMNA
gene id: 61622:LMNA
uniprot id: A0A2K6QHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

61622:TBR1
gene id: 61622:TBR1
uniprot id: A0A2K6NA61
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

61622:SMIM19
gene id: 61622:SMIM19
uniprot id: A0A2K6NFY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM19 family.
messages: Membrane

61622:RBBP8
gene id: 61622:RBBP8
uniprot id: A0A2K6NEW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

61622:STK10
gene id: 61622:STK10
uniprot id: A0A2K6RJM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

61622:YIPF1
gene id: 61622:YIPF1
uniprot id: A0A2K6RU41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

61622:GDF9
gene id: 61622:GDF9
uniprot id: A0A2K6PX87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

61622:PYCR1
gene id: 61622:PYCR1
uniprot id: A0A2K6Q3R5
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

61622:SLC5A1
gene id: 61622:SLC5A1
uniprot id: A0A2K6P6A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

61622:LAMC1
gene id: 61622:LAMC1
uniprot id: A0A2K6NS10
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: basement membrane

61622:TXK
gene id: 61622:TXK
uniprot id: A0A2K6RME8
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:DCLK1
gene id: 61622:DCLK1
uniprot id: A0A2K6NKI4
uniprot id: A0A2K6NKJ9
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

61622:ZSCAN18
gene id: 61622:ZSCAN18
uniprot id: A0A2K6P121
names: Subcellular Location Annotation
messages: Nucleus

61622:HSPA4L
gene id: 61622:HSPA4L
uniprot id: A0A2K6RK58
uniprot id: A0A2K6RK86
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61622:NFX1
gene id: 61622:NFX1
uniprot id: A0A2K6NRI3
uniprot id: A0A2K6NRI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

61622:APP
gene id: 61622:APP
uniprot id: A0A2K6QWL4
uniprot id: A0A2K6QWN0
uniprot id: A0A2K6QWQ6
uniprot id: A0A2K6QWS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endoplasmic reticulum
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

61622:LOC104670791
gene id: 61622:LOC104670791
uniprot id: A0A2K6NKS8
uniprot id: A0A2K6NKU0
uniprot id: A0A2K6NKU3
names: Caution
names: Similarity
messages: Belongs to the MSANTD3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:THADA
gene id: 61622:THADA
uniprot id: A0A2K6PMA7
names: Similarity
messages: Belongs to the THADA family.

61622:PIAS3
gene id: 61622:PIAS3
uniprot id: A0A2K6Q700
uniprot id: A0A2K6Q725
names: Similarity
messages: Belongs to the PIAS family.

61622:CNRIP1
gene id: 61622:CNRIP1
uniprot id: A0A2K6PQS5
uniprot id: A0A2K6PQT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

61622:LOC104680801
gene id: 61622:LOC104680801
uniprot id: A0A2K6NG68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

61622:LOC104658500
gene id: 61622:LOC104658500
uniprot id: A0A2K6NQF4
names: Similarity
messages: Belongs to the intermediate filament family.

61622:TPPP2
gene id: 61622:TPPP2
uniprot id: A0A2K6NME1
names: Similarity
messages: Belongs to the TPPP family.

61622:BRINP2
gene id: 61622:BRINP2
uniprot id: A0A2K6RMF1
names: Similarity
messages: Belongs to the BRINP family.

61622:ASPA
gene id: 61622:ASPA
uniprot id: A0A2K6NHR9
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

61622:FSHR
gene id: 61622:FSHR
uniprot id: A0A2K6R123
uniprot id: A0A2K6R127
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

61622:LOC104663549
gene id: 61622:LOC104663549
uniprot id: A0A2K6NTJ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:SFTPC
gene id: 61622:SFTPC
uniprot id: A0A2K6QM30
names: Function
names: Subcellular Location Annotation
messages: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
messages: surface film

61622:PAPOLG
gene id: 61622:PAPOLG
uniprot id: A0A2K6Q682
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

61622:LOC104666351
gene id: 61622:LOC104666351
uniprot id: A0A2K6QNS2
uniprot id: A0A2K6QNS9
uniprot id: A0A2K6QNT7
uniprot id: A0A2K6QNU0
uniprot id: A0A2K6QNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

61622:ANXA11
gene id: 61622:ANXA11
uniprot id: A0A2K6NKI5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

61622:RHBDL1
gene id: 61622:RHBDL1
uniprot id: A0A2K6N977
names: Subcellular Location Annotation
messages: Membrane

61622:OLFM2
gene id: 61622:OLFM2
uniprot id: A0A2K6P8R0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

61622:HAPLN1
gene id: 61622:HAPLN1
uniprot id: A0A2K6Q889
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:CTNNA1
gene id: 61622:CTNNA1
uniprot id: A0A2K6N8M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: cytoskeleton

61622:CASTOR1
gene id: 61622:CASTOR1
uniprot id: A0A2K6RJT5
uniprot id: A0A2K6RJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GATS family.
messages: cytosol

61622:NMNAT2
gene id: 61622:NMNAT2
uniprot id: A0A2K6RGT2
uniprot id: A0A2K6RGY1
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

61622:USB1
gene id: 61622:USB1
uniprot id: A0A2K6NZ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.

61622:EXO5
gene id: 61622:EXO5
uniprot id: A0A2K6N9F9
names: Similarity
messages: Belongs to the EXO5 family.

61622:DHX9
gene id: 61622:DHX9
uniprot id: A0A2K6RQU6
uniprot id: A0A2K6RQW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DEAH subfamily.
messages: Nucleus

61622:MARK3
gene id: 61622:MARK3
uniprot id: A0A2K6PWG5
uniprot id: A0A2K6PWG8
uniprot id: A0A2K6PWH7
uniprot id: A0A2K6PWH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

61622:LZTFL1
gene id: 61622:LZTFL1
uniprot id: A0A2K6RGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

61622:RAD23A
gene id: 61622:RAD23A
uniprot id: A0A2K6QWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

61622:LOC104658880
gene id: 61622:LOC104658880
uniprot id: A0A2K6NCF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

61622:HBE1
gene id: 61622:HBE1
uniprot id: A0A2K6R3K8
names: Similarity
messages: Belongs to the globin family.

61622:LOC104663468
gene id: 61622:LOC104663468
uniprot id: A0A2K6NMG4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

61622:INPP5D
gene id: 61622:INPP5D
uniprot id: A0A2K6P6R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane

61622:CDK14
gene id: 61622:CDK14
uniprot id: A0A2K6NNN8
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:SLC11A1
gene id: 61622:SLC11A1
uniprot id: A0A2K6R0A9
names: Similarity
messages: Belongs to the NRAMP family.

61622:CHD9
gene id: 61622:CHD9
uniprot id: A0A2K6PPM7
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

61622:IL11RA
gene id: 61622:IL11RA
uniprot id: A0A2K6RH39
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 3 subfamily.

61622:HINT2
gene id: 61622:HINT2
uniprot id: A0A2K6Q161
names: Similarity
messages: Belongs to the HINT family.

61622:LOC104656372
gene id: 61622:LOC104656372
uniprot id: A0A2K6NC70
names: Subcellular Location Annotation
messages: Membrane

61622:CNOT7
gene id: 61622:CNOT7
uniprot id: A0A2K6PY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

61622:NDST1
gene id: 61622:NDST1
uniprot id: A0A2K6REY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

61622:PPM1F
gene id: 61622:PPM1F
uniprot id: A0A2K6RSP0
names: Similarity
messages: Belongs to the PP2C family.

61622:FGF10
gene id: 61622:FGF10
uniprot id: A0A2K6NK18
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:SLC46A1
gene id: 61622:SLC46A1
uniprot id: A0A2K6QAC6
names: Subcellular Location Annotation
messages: Membrane

61622:RNF13
gene id: 61622:RNF13
uniprot id: A0A2K6PK86
names: Subcellular Location Annotation
messages: Membrane

61622:SATB1
gene id: 61622:SATB1
uniprot id: A0A2K6QY30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

61622:PTGER4
gene id: 61622:PTGER4
uniprot id: A0A2K6PV71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FEM1A.
messages: Membrane
messages: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

61622:CEMIP2
gene id: 61622:CEMIP2
uniprot id: A0A2K6RKQ0
names: Similarity
messages: Belongs to the CEMIP family.

61622:HESX1
gene id: 61622:HESX1
uniprot id: A0A2K6PIP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANF homeobox family.
messages: Nucleus

61622:CAMLG
gene id: 61622:CAMLG
uniprot id: A0A2K6NKK0
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

61622:TRPC3
gene id: 61622:TRPC3
uniprot id: A0A2K6QQM8
names: Subcellular Location Annotation
messages: Membrane

61622:CLDND2
gene id: 61622:CLDND2
uniprot id: A0A2K6PBU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

61622:RPL31
gene id: 61622:RPL31
uniprot id: A0A2K6NEN8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

61622:LOC104681252
gene id: 61622:LOC104681252
uniprot id: A0A2K6RXM0
names: Subcellular Location Annotation
messages: Nucleus

61622:TPRA1
gene id: 61622:TPRA1
uniprot id: A0A2K6Q8K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

61622:CLCNKB
gene id: 61622:CLCNKB
uniprot id: A0A2K6Q1M4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:CACNA2D1
gene id: 61622:CACNA2D1
uniprot id: A0A2K6QMJ7
uniprot id: A0A2K6QMN3
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

61622:CDK4
gene id: 61622:CDK4
uniprot id: A0A2K6P415
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:RAD52
gene id: 61622:RAD52
uniprot id: A0A2K6P4T0
names: Similarity
messages: Belongs to the RAD52 family.

61622:MYLK4
gene id: 61622:MYLK4
uniprot id: A0A2K6QIH8
names: Similarity
messages: Belongs to the protein kinase superfamily.

61622:PDIA3
gene id: 61622:PDIA3
uniprot id: A0A2K6Q133
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

61622:PAPOLA
gene id: 61622:PAPOLA
uniprot id: A0A2K6NQG3
uniprot id: A0A2K6NQH0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

61622:CRABP2
gene id: 61622:CRABP2
uniprot id: A0A2K6PFH8
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:CCDC126
gene id: 61622:CCDC126
uniprot id: A0A2K6NMR5
names: Subcellular Location Annotation
messages: Secreted

61622:HYOU1
gene id: 61622:HYOU1
uniprot id: A0A2K6Q5D0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

61622:XKR5
gene id: 61622:XKR5
uniprot id: A0A2K6QXD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

61622:RPS27
gene id: 61622:RPS27
uniprot id: A0A2K6N9I7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

61622:ACTC1
gene id: 61622:ACTC1
uniprot id: A0A2K6QJH6
names: Similarity
messages: Belongs to the actin family.

61622:MBL2
gene id: 61622:MBL2
uniprot id: A0A2K6PF36
names: Function
names: Subunit
messages: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
messages: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2 (By similarity). Interacts with MEP1A and MEP1B and may inhibit their catalytic activity.

61622:MST1
gene id: 61622:MST1
uniprot id: A0A2K6NTA8
names: Caution
names: Similarity
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:GIMAP1
gene id: 61622:GIMAP1
uniprot id: A0A2K6P5B9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

61622:GCLC
gene id: 61622:GCLC
uniprot id: A0A2K6QS92
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

61622:KRT39
gene id: 61622:KRT39
uniprot id: A0A2K6PEL5
names: Similarity
messages: Belongs to the intermediate filament family.

61622:WDR91
gene id: 61622:WDR91
uniprot id: A0A2K6P778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

61622:GALNT5
gene id: 61622:GALNT5
uniprot id: A0A2K6NY26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

61622:LOC104673860
gene id: 61622:LOC104673860
uniprot id: A0A2K6Q362
names: Similarity
messages: Belongs to the MHC class II family.

61622:VTI1A
gene id: 61622:VTI1A
uniprot id: A0A2K6PX38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

61622:NPLOC4
gene id: 61622:NPLOC4
uniprot id: A0A2K6NHB1
names: Similarity
messages: Belongs to the NPL4 family.

61622:SNX2
gene id: 61622:SNX2
uniprot id: A0A2K6RFN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium

61622:HAT1
gene id: 61622:HAT1
uniprot id: A0A2K6REU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.
messages: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac).

61622:PRKCH
gene id: 61622:PRKCH
uniprot id: A0A2K6P6H6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

61622:HNRNPUL2
gene id: 61622:HNRNPUL2
uniprot id: A0A2K6QA66
names: Subcellular Location Annotation
messages: Nucleus

61622:PIWIL4
gene id: 61622:PIWIL4
uniprot id: A0A2K6NHP8
names: Similarity
messages: Belongs to the argonaute family.

61622:TSC22D2
gene id: 61622:TSC22D2
uniprot id: A0A2K6PKC2
uniprot id: A0A2K6PKC4
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

61622:RPS6
gene id: 61622:RPS6
uniprot id: A0A2K6Q9V0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

61622:CCDC124
gene id: 61622:CCDC124
uniprot id: A0A2K6QBM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CCDC124 family.
messages: Interacts with RASGEF1B.
messages: Required for proper progression of late cytokinetic stages.

61622:SH3YL1
gene id: 61622:SH3YL1
uniprot id: A0A2K6R017
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

61622:ZDHHC12
gene id: 61622:ZDHHC12
uniprot id: A0A2K6QU98
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

61622:LOC104667410
gene id: 61622:LOC104667410
uniprot id: A0A2K6PVS2
names: Similarity
messages: Belongs to the MIF family.

61622:ITK
gene id: 61622:ITK
uniprot id: A0A2K6QBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cytoplasm

61622:PPARG
gene id: 61622:PPARG
uniprot id: A0A2K6RRF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

61622:MYOC
gene id: 61622:MYOC
uniprot id: A0A2K6P1X2
names: Caution
names: Subcellular Location Annotation
messages: Endoplasmic reticulum
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion intermembrane space
messages: Mitochondrion outer membrane
messages: Rough endoplasmic reticulum
messages: cilium
messages: extracellular exosome
messages: extracellular matrix

61622:TRADD
gene id: 61622:TRADD
uniprot id: A0A2K6N831
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

61622:TMEM265
gene id: 61622:TMEM265
uniprot id: A0A2K6R5M4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:DNAH1
gene id: 61622:DNAH1
uniprot id: A0A2K6RAT4
names: Similarity
messages: Belongs to the dynein heavy chain family.

61622:MRPS18A
gene id: 61622:MRPS18A
uniprot id: A0A2K6RA28
names: Subcellular Location Annotation
messages: Mitochondrion

61622:MPC1
gene id: 61622:MPC1
uniprot id: A0A2K6P738
uniprot id: A0A2K6P770
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

61622:CHI3L1
gene id: 61622:CHI3L1
uniprot id: A0A2K6PRR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 18 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Monomer.
messages: extracellular space

61622:GFRA1
gene id: 61622:GFRA1
uniprot id: A0A2K6P5J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

61622:OTULINL
gene id: 61622:OTULINL
uniprot id: A0A2K6NYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

61622:HBM
gene id: 61622:HBM
uniprot id: A0A2K6RPM9
names: Similarity
messages: Belongs to the globin family.

61622:SLC66A3
gene id: 61622:SLC66A3
uniprot id: A0A2K6QHM0
uniprot id: A0A2K6QHN6
names: Subcellular Location Annotation
messages: Membrane

61622:NIBAN2
gene id: 61622:NIBAN2
uniprot id: A0A2K6Q061
names: Similarity
messages: Belongs to the Niban family.

61622:IKBKE
gene id: 61622:IKBKE
uniprot id: A0A2K6Q573
names: Subcellular Location Annotation
messages: Cytoplasm

61622:NMU
gene id: 61622:NMU
uniprot id: A0A2K6Q3J0
uniprot id: A0A2K6Q3J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

61622:MYH10
gene id: 61622:MYH10
uniprot id: A0A2K6NJ14
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

61622:VLDLR
gene id: 61622:VLDLR
uniprot id: A0A2K6PNB5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: clathrin-coated pit

61622:TCN2
gene id: 61622:TCN2
uniprot id: A0A2K6Q814
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

61622:PIGO
gene id: 61622:PIGO
uniprot id: A0A2K6QMW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:RBM42
gene id: 61622:RBM42
uniprot id: A0A2K6RA67
uniprot id: A0A2K6RA81
names: Similarity
messages: Belongs to the RRM RBM42 family.

61622:TMEM9
gene id: 61622:TMEM9
uniprot id: A0A2K6QEN9
names: Similarity
messages: Belongs to the TMEM9 family.

61622:SUPT6H
gene id: 61622:SUPT6H
uniprot id: A0A2K6Q3B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII).

61622:SLITRK2
gene id: 61622:SLITRK2
uniprot id: A0A2K6NAD5
names: Similarity
messages: Belongs to the SLITRK family.

61622:SYNDIG1
gene id: 61622:SYNDIG1
uniprot id: A0A2K6PUY4
names: Similarity
messages: Belongs to the CD225/Dispanin family.

61622:KBTBD8
gene id: 61622:KBTBD8
uniprot id: A0A2K6QS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

61622:FAM83F
gene id: 61622:FAM83F
uniprot id: A0A2K6PCA2
names: Similarity
messages: Belongs to the FAM83 family.

61622:MYLK2
gene id: 61622:MYLK2
uniprot id: A0A2K6R6G7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cytoplasm
messages: May interact with centrin.

61622:POLR2A
gene id: 61622:POLR2A
uniprot id: A0A2K6P1E5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

61622:TRAM1L1
gene id: 61622:TRAM1L1
uniprot id: A0A2K6NA32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

61622:GPR55
gene id: 61622:GPR55
uniprot id: A0A2K6NE51
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

61622:TFIP11
gene id: 61622:TFIP11
uniprot id: A0A2K6PZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

61622:LOC104670640
gene id: 61622:LOC104670640
uniprot id: A0A2K6PR60
names: Similarity
messages: Belongs to the intermediate filament family.

61622:LALBA
gene id: 61622:LALBA
uniprot id: A0A2K6P4R7
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

61622:C16H9orf78
gene id: 61622:C16H9orf78
uniprot id: A0A2K6R7F4
names: Similarity
messages: Belongs to the TLS1 family.

61622:DPYSL3
gene id: 61622:DPYSL3
uniprot id: A0A2K6P1V4
uniprot id: A0A2K6P1V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Cytoplasm
messages: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
messages: growth cone

61622:PLOD2
gene id: 61622:PLOD2
uniprot id: A0A2K6PEF2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

61622:EMC8
gene id: 61622:EMC8
uniprot id: A0A2K6NVT4
uniprot id: A0A2K6NVT9
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

61622:THBS4
gene id: 61622:THBS4
uniprot id: A0A2K6R566
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:B3GALT2
gene id: 61622:B3GALT2
uniprot id: A0A2K6NKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

61622:NDUFAB1
gene id: 61622:NDUFAB1
uniprot id: A0A2K6QJ67
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

61622:PKP2
gene id: 61622:PKP2
uniprot id: A0A2K6N846
names: Similarity
messages: Belongs to the beta-catenin family.

61622:CACNG1
gene id: 61622:CACNG1
uniprot id: A0A2K6N8T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

61622:USE1
gene id: 61622:USE1
uniprot id: A0A2K6QBP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:C12H1orf174
gene id: 61622:C12H1orf174
uniprot id: A0A2K6QC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

61622:SLC2A11
gene id: 61622:SLC2A11
uniprot id: A0A2K6NT49
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

61622:UROS
gene id: 61622:UROS
uniprot id: A0A2K6RL81
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

61622:NUDT1
gene id: 61622:NUDT1
uniprot id: A0A2K6NTM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Monomer.
messages: Nucleus

61622:PIH1D2
gene id: 61622:PIH1D2
uniprot id: A0A2K6PN05
names: Similarity
messages: Belongs to the PIH1 family.

61622:ARHGAP26
gene id: 61622:ARHGAP26
uniprot id: A0A2K6RE70
names: Subcellular Location Annotation
messages: cytoskeleton
messages: focal adhesion

61622:SLC19A1
gene id: 61622:SLC19A1
uniprot id: A0A2K6PLW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: Transporter that mediates the import of reduced folates.

61622:DEDD
gene id: 61622:DEDD
uniprot id: A0A2K6QCA5
names: Subcellular Location Annotation
messages: nucleolus

61622:SRP54
gene id: 61622:SRP54
uniprot id: A0A2K6R3N7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.
messages: Cytoplasm
messages: Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.
messages: Nucleus speckle

61622:LOC104661648
gene id: 61622:LOC104661648
uniprot id: A0A2K6R0D6
names: Similarity
messages: Belongs to the tumor necrosis factor family.

61622:PRDX1
gene id: 61622:PRDX1
uniprot id: A0A2K6RDT0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

61622:DEGS1
gene id: 61622:DEGS1
uniprot id: A0A2K6NIV5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane
messages: Mitochondrion membrane

61622:LOC104671835
gene id: 61622:LOC104671835
uniprot id: A0A2K6RT88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

61622:MAML3
gene id: 61622:MAML3
uniprot id: A0A2K6QSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

61622:TOP3B
gene id: 61622:TOP3B
uniprot id: A0A2K6RCP5
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

61622:OAZ1
gene id: 61622:OAZ1
uniprot id: A0A2K6QEV7
names: Similarity
messages: Belongs to the ODC antizyme family.

61622:PITX3
gene id: 61622:PITX3
uniprot id: A0A2K6NKW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

61622:DNAJA4
gene id: 61622:DNAJA4
uniprot id: A0A2K6PVQ3
uniprot id: A0A2K6PVQ4
names: Subcellular Location Annotation
messages: Membrane

61622:SLC22A1
gene id: 61622:SLC22A1
uniprot id: A0A2K6PXN0
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

61622:ZNF24
gene id: 61622:ZNF24
uniprot id: A0A2K6PR97
names: Subcellular Location Annotation
messages: Nucleus

61622:TYRO3
gene id: 61622:TYRO3
uniprot id: A0A2K6PSR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Cell membrane
messages: Membrane

61622:IL9
gene id: 61622:IL9
uniprot id: A0A2K6QSK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-7/IL-9 family.
messages: Secreted

61622:LHX4
gene id: 61622:LHX4
uniprot id: A0A2K6RHB6
names: Subcellular Location Annotation
messages: Nucleus

61622:CKAP2
gene id: 61622:CKAP2
uniprot id: A0A2K6RQC5
names: Similarity
messages: Belongs to the CKAP2 family.

61622:KIF3C
gene id: 61622:KIF3C
uniprot id: A0A2K6RX66
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:KRT36
gene id: 61622:KRT36
uniprot id: A0A2K6Q1A4
names: Similarity
messages: Belongs to the intermediate filament family.

61622:DMRTA1
gene id: 61622:DMRTA1
uniprot id: A0A2K6PV28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

61622:SLC25A30
gene id: 61622:SLC25A30
uniprot id: A0A2K6PL88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

61622:SPOUT1
gene id: 61622:SPOUT1
uniprot id: A0A2K6QIX3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

61622:MCTP1
gene id: 61622:MCTP1
uniprot id: A0A2K6PU71
uniprot id: A0A2K6PU89
names: Subcellular Location Annotation
messages: Membrane

61622:TAF7L
gene id: 61622:TAF7L
uniprot id: A0A2K6PZN5
uniprot id: A0A2K6PZP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

61622:FBXO32
gene id: 61622:FBXO32
uniprot id: A0A2K6R033
names: Subcellular Location Annotation
messages: Nucleus

61622:MOGAT2
gene id: 61622:MOGAT2
uniprot id: A0A2K6NJJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:TECPR1
gene id: 61622:TECPR1
uniprot id: A0A2K6Q1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TECPR1 family.
messages: Lysosome membrane
messages: autophagosome membrane

61622:CAB39L
gene id: 61622:CAB39L
uniprot id: A0A2K6NFJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

61622:RPS10
gene id: 61622:RPS10
uniprot id: A0A2K6NAJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

61622:PARD6B
gene id: 61622:PARD6B
uniprot id: A0A2K6RES7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cell membrane
messages: Cytoplasm
messages: tight junction

61622:LOC104654534
gene id: 61622:LOC104654534
uniprot id: A0A2K6NL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

61622:COPB1
gene id: 61622:COPB1
uniprot id: A0A2K6Q0G0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Endoplasmic reticulum-Golgi intermediate compartment
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

61622:IGF2BP3
gene id: 61622:IGF2BP3
uniprot id: A0A2K6Q2M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Nucleus
messages: P-body
messages: Stress granule

61622:GSK3A
gene id: 61622:GSK3A
uniprot id: A0A2K6NJW0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

61622:PDK1
gene id: 61622:PDK1
uniprot id: A0A2K6RN94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

61622:PLXNC1
gene id: 61622:PLXNC1
uniprot id: A0A2K6N955
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:RAB18
gene id: 61622:RAB18
uniprot id: A0A2K6QZ12
uniprot id: A0A2K6QZ24
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

61622:TFPI2
gene id: 61622:TFPI2
uniprot id: A0A2K6R9B6
names: Subcellular Location Annotation
messages: Secreted

61622:LOC104675038
gene id: 61622:LOC104675038
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:ANGPTL4
gene id: 61622:ANGPTL4
uniprot id: A0A2K6P1G8
names: Subcellular Location Annotation
messages: Secreted

61622:TARS1
gene id: 61622:TARS1
uniprot id: A0A2K6P8E8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

61622:LOC104675477
gene id: 61622:LOC104675477
uniprot id: A0A2K6QCY1
names: Subcellular Location Annotation
messages: Membrane
messages: chromaffin granule membrane

61622:BCAR1
gene id: 61622:BCAR1
uniprot id: A0A2K6PGT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

61622:CAP2
gene id: 61622:CAP2
uniprot id: A0A2K6PI80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

61622:NXPH2
gene id: 61622:NXPH2
uniprot id: A0A2K6NWS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

61622:FGD3
gene id: 61622:FGD3
uniprot id: A0A2K6N8G6
names: Subcellular Location Annotation
messages: cytoskeleton

61622:CLCA1
gene id: 61622:CLCA1
uniprot id: A0A2K6NXP8
names: Similarity
messages: Belongs to the CLCR family.

61622:TMEM50A
gene id: 61622:TMEM50A
uniprot id: A0A2K6QEV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

61622:VAX2
gene id: 61622:VAX2
uniprot id: A0A2K6QFA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMX homeobox family.
messages: Nucleus

61622:MPHOSPH8
gene id: 61622:MPHOSPH8
uniprot id: A0A2K6RME7
names: Subcellular Location Annotation
messages: Nucleus

61622:DPPA5
gene id: 61622:DPPA5
uniprot id: A0A2K6RWW2
names: Similarity
messages: Belongs to the KHDC1 family.

61622:RAD54L2
gene id: 61622:RAD54L2
uniprot id: A0A2K6RA17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

61622:SEMA4C
gene id: 61622:SEMA4C
uniprot id: A0A2K6N7T2
names: Caution
names: Similarity
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:SLC4A4
gene id: 61622:SLC4A4
uniprot id: A0A2K6Q683
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:EXOSC7
gene id: 61622:EXOSC7
uniprot id: A0A2K6QIV8
names: Subcellular Location Annotation
messages: Cytoplasm

61622:CENPE
gene id: 61622:CENPE
uniprot id: A0A2K6NW65
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:LOC104672857
gene id: 61622:LOC104672857
uniprot id: A0A2K6RVK7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

61622:C1GALT1
gene id: 61622:C1GALT1
uniprot id: A0A2K6NXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

61622:SLC23A3
gene id: 61622:SLC23A3
uniprot id: A0A2K6PVC1
names: Subcellular Location Annotation
messages: Membrane

61622:TXNL4B
gene id: 61622:TXNL4B
uniprot id: A0A2K6QH87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

61622:JMJD1C
gene id: 61622:JMJD1C
uniprot id: A0A2K6R1I7
uniprot id: A0A2K6R1J0
names: Subcellular Location Annotation
messages: Nucleus

61622:FSCN2
gene id: 61622:FSCN2
uniprot id: A0A2K6PYT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

61622:RBX1
gene id: 61622:RBX1
uniprot id: A0A2K6NYT4
names: Similarity
messages: Belongs to the RING-box family.

61622:EFNB2
gene id: 61622:EFNB2
uniprot id: A0A2K6RIP6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:LOC104679065
gene id: 61622:LOC104679065
uniprot id: A0A2K6Q3E3
uniprot id: A0A2K6Q3E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

61622:ETS1
gene id: 61622:ETS1
uniprot id: A0A2K6NIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Cytoplasm
messages: Nucleus

61622:HOXC10
gene id: 61622:HOXC10
uniprot id: A0A2K6REX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

61622:AFG3L2
gene id: 61622:AFG3L2
uniprot id: A0A2K6QHN1
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

61622:ITGA6
gene id: 61622:ITGA6
uniprot id: A0A2K6Q8D5
uniprot id: A0A2K6Q8E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

61622:FAM120B
gene id: 61622:FAM120B
uniprot id: A0A2K6P407
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

61622:SOAT1
gene id: 61622:SOAT1
uniprot id: A0A2K6Q3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:TRPM4
gene id: 61622:TRPM4
uniprot id: A0A2K6N887
names: Subcellular Location Annotation
messages: Membrane

61622:POU5F1
gene id: 61622:POU5F1
uniprot id: A0A2K6NEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-5 subfamily.
messages: Nucleus

61622:ST6GALNAC5
gene id: 61622:ST6GALNAC5
uniprot id: A0A2K6RU11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

61622:CCSER2
gene id: 61622:CCSER2
uniprot id: A0A2K6RJC2
names: Similarity
messages: Belongs to the CCSER family.

61622:PLSCR4
gene id: 61622:PLSCR4
uniprot id: A0A2K6QZ91
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

61622:SOX2
gene id: 61622:SOX2
uniprot id: A0A2K6NEL0
names: Subcellular Location Annotation
messages: Nucleus

61622:GAL3ST3
gene id: 61622:GAL3ST3
uniprot id: A0A2K6PTK9
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

61622:PDC
gene id: 61622:PDC
uniprot id: A0A2K6PHP6
names: Similarity
messages: Belongs to the phosducin family.

61622:PPIL1
gene id: 61622:PPIL1
uniprot id: A0A2K6RUA0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

61622:SEMA3B
gene id: 61622:SEMA3B
uniprot id: A0A2K6QIG3
names: Similarity
messages: Belongs to the semaphorin family.

61622:LOC104664028
gene id: 61622:LOC104664028
uniprot id: A0A2K6R6E7
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

61622:SST
gene id: 61622:SST
uniprot id: A0A2K6Q2V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

61622:MDGA1
gene id: 61622:MDGA1
uniprot id: A0A2K6P215
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

61622:THNSL1
gene id: 61622:THNSL1
uniprot id: A0A2K6NC83
names: Similarity
messages: Belongs to the threonine synthase family.

61622:BZW2
gene id: 61622:BZW2
uniprot id: A0A2K6QJR4
names: Similarity
messages: Belongs to the BZW family.

61622:PTPN11
gene id: 61622:PTPN11
uniprot id: A0A2K6PEZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

61622:P2RX4
gene id: 61622:P2RX4
uniprot id: A0A2K6R6D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

61622:LOC104662359
gene id: 61622:LOC104662359
uniprot id: A0A2K6PD63
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

61622:MCEE
gene id: 61622:MCEE
uniprot id: A0A2K6NKE3
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

61622:CCDC103
gene id: 61622:CCDC103
uniprot id: A0A2K6PB60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC103/PR46b family.
messages: Cytoplasm
messages: Dynein-attachment factor required for cilia motility.
messages: Homodimer.
messages: flagellum

61622:RSPH3
gene id: 61622:RSPH3
uniprot id: A0A2K6P9B7
names: Similarity
messages: Belongs to the flagellar radial spoke RSP3 family.

61622:ACVRL1
gene id: 61622:ACVRL1
uniprot id: A0A2K6PKT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

61622:RPS23
gene id: 61622:RPS23
uniprot id: A0A2K6PRF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

61622:ADAMTS20
gene id: 61622:ADAMTS20
uniprot id: A0A2K6QXR7
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

61622:CLRN1
gene id: 61622:CLRN1
uniprot id: A0A2K6QAC0
uniprot id: A0A2K6QAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

61622:EYA3
gene id: 61622:EYA3
uniprot id: A0A2K6QCI1
uniprot id: A0A2K6QCI6
uniprot id: A0A2K6QCL0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

61622:CDC26
gene id: 61622:CDC26
uniprot id: A0A2K6PNX1
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

61622:ATP13A1
gene id: 61622:ATP13A1
uniprot id: A0A2K6PPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

61622:KCTD6
gene id: 61622:KCTD6
uniprot id: A0A2K6Q3N9
names: Subcellular Location Annotation
messages: Cell membrane

61622:RPL23
gene id: 61622:RPL23
uniprot id: A0A2K6P6C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

61622:VPS33A
gene id: 61622:VPS33A
uniprot id: A0A2K6NP05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

61622:LOC104676449
gene id: 61622:LOC104676449
uniprot id: A0A2K6NTS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

61622:PTBP1
gene id: 61622:PTBP1
uniprot id: A0A2K6NIM6
uniprot id: A0A2K6NIN4
names: Subcellular Location Annotation
messages: Nucleus

61622:RBP2
gene id: 61622:RBP2
uniprot id: A0A2K6P4P6
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

61622:AGTPBP1
gene id: 61622:AGTPBP1
uniprot id: A0A2K6QAN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

61622:VAMP5
gene id: 61622:VAMP5
uniprot id: A0A2K6PEL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

61622:HS2ST1
gene id: 61622:HS2ST1
uniprot id: A0A2K6P762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Membrane

61622:CA7
gene id: 61622:CA7
uniprot id: A0A2K6QWA0
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

61622:CHRNA6
gene id: 61622:CHRNA6
uniprot id: A0A2K6QHN9
uniprot id: A0A2K6QHP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

61622:TOP2A
gene id: 61622:TOP2A
uniprot id: A0A2K6PZD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

61622:SPIN4
gene id: 61622:SPIN4
uniprot id: A0A2K6NCK0
names: Similarity
messages: Belongs to the SPIN/STSY family.

61622:LOC104657390
gene id: 61622:LOC104657390
uniprot id: A0A2K6NGZ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the large ribosomal subunit.

61622:ITGB5
gene id: 61622:ITGB5
uniprot id: A0A2K6PYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

61622:YIPF7
gene id: 61622:YIPF7
uniprot id: A0A2K6R557
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ZACN
gene id: 61622:ZACN
uniprot id: A0A2K6NVI6
names: Subcellular Location Annotation
messages: Membrane

61622:COQ6
gene id: 61622:COQ6
uniprot id: A0A2K6RX83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Cell projection
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Golgi apparatus
messages: Mitochondrion inner membrane

61622:CASP8
gene id: 61622:CASP8
uniprot id: A0A2K6P9P0
names: Similarity
messages: Belongs to the peptidase C14A family.

61622:ASB14
gene id: 61622:ASB14
uniprot id: A0A2K6PZ10
names: Similarity
messages: Belongs to the ankyrin SOCS box (ASB) family.

61622:AVPR2
gene id: 61622:AVPR2
uniprot id: A0A2K6Q9U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
messages: Membrane

61622:KIF13B
gene id: 61622:KIF13B
uniprot id: A0A2K6RJ11
uniprot id: A0A2K6RJ50
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

61622:VGLL4
gene id: 61622:VGLL4
uniprot id: A0A2K6PLT0
uniprot id: A0A2K6PLU5
uniprot id: A0A2K6PLY8
names: Function
names: Similarity
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.

61622:NNMT
gene id: 61622:NNMT
uniprot id: A0A2K6QAM0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.

61622:REM2
gene id: 61622:REM2
uniprot id: A0A2K6N7N2
names: Subcellular Location Annotation
messages: Cell membrane

61622:TFPI
gene id: 61622:TFPI
uniprot id: A0A2K6P8A1
uniprot id: A0A2K6P8B5
names: Subcellular Location Annotation
messages: Secreted

61622:PLIN5
gene id: 61622:PLIN5
uniprot id: A0A2K6RM31
names: Similarity
messages: Belongs to the perilipin family.

61622:LOC104679831
gene id: 61622:LOC104679831
uniprot id: A0A2K6QGT0
names: Subunit
messages: Monomer.

61622:GRAMD1B
gene id: 61622:GRAMD1B
uniprot id: A0A2K6RHL1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

61622:LOC104680098
gene id: 61622:LOC104680098
uniprot id: A0A2K6PKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

61622:RAB29
gene id: 61622:RAB29
uniprot id: A0A2K6RU56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

61622:FGF11
gene id: 61622:FGF11
uniprot id: A0A2K6NG87
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

61622:LOC104663749
gene id: 61622:LOC104663749
uniprot id: A0A2K6RI84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
messages: Secreted

61622:MRPL49
gene id: 61622:MRPL49
uniprot id: A0A2K6RPW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

61622:PRF1
gene id: 61622:PRF1
uniprot id: A0A2K6QMY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

61622:LOC104655878
gene id: 61622:LOC104655878
uniprot id: A0A2K6QKI4
names: Similarity
messages: Belongs to the cytochrome b5 family.

61622:EREG
gene id: 61622:EREG
uniprot id: A0A2K6Q641
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:ETFDH
gene id: 61622:ETFDH
uniprot id: A0A2K6PUT4
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

61622:DCSTAMP
gene id: 61622:DCSTAMP
uniprot id: A0A2K6PDD3
uniprot id: A0A2K6PDI2
names: Subcellular Location Annotation
messages: Membrane

61622:LOC104662355
gene id: 61622:LOC104662355
uniprot id: A0A2K6RJI6
names: Similarity
messages: Belongs to the cytochrome P450 family.

61622:APOBEC3C
gene id: 61622:APOBEC3C
uniprot id: A0A2K6NY87
names: Subcellular Location Annotation
messages: Cytoplasm

61622:TRMT61A
gene id: 61622:TRMT61A
uniprot id: A0A2K6RAR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

61622:LGI4
gene id: 61622:LGI4
uniprot id: A0A2K6PRQ4
names: Subcellular Location Annotation
messages: Secreted

61622:C8A
gene id: 61622:C8A
uniprot id: A0A2K6P7P3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

61622:TYRP1
gene id: 61622:TYRP1
uniprot id: A0A2K6Q4A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

61622:SGIP1
gene id: 61622:SGIP1
uniprot id: A0A2K6RA23
uniprot id: A0A2K6RA55
names: Function
names: Subcellular Location Annotation
messages: May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.
messages: clathrin-coated pit

61622:LOC104657859
gene id: 61622:LOC104657859
uniprot id: A0A2K6RXF8
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family.
messages: Monomer.

61622:NOL11
gene id: 61622:NOL11
uniprot id: A0A2K6N8X7
names: Subcellular Location Annotation
messages: nucleolus

61622:SLC30A5
gene id: 61622:SLC30A5
uniprot id: A0A2K6R3N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Functions as a zinc transporter.
messages: Membrane
messages: trans-Golgi network membrane

61622:FAT4
gene id: 61622:FAT4
uniprot id: A0A2K6PPR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

61622:FCN2
gene id: 61622:FCN2
uniprot id: A0A2K6NA97
names: Similarity
messages: Belongs to the ficolin lectin family.

61622:SULT1C4
gene id: 61622:SULT1C4
uniprot id: A0A2K6QZP8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

61622:BAZ1B
gene id: 61622:BAZ1B
uniprot id: A0A2K6Q0U1
names: Subcellular Location Annotation
messages: Nucleus

61622:NSF
gene id: 61622:NSF
uniprot id: A0A2K6P9N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

61622:RBM5
gene id: 61622:RBM5
uniprot id: A0A2K6R421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

61622:LOC104656391
gene id: 61622:LOC104656391
uniprot id: A0A2K6NLN9
names: Subcellular Location Annotation
messages: Membrane

61622:PDCL2
gene id: 61622:PDCL2
uniprot id: A0A2K6NML5
names: Similarity
messages: Belongs to the phosducin family.

61622:OPTN
gene id: 61622:OPTN
uniprot id: A0A2K6RCN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

61622:CDKN2AIPNL
gene id: 61622:CDKN2AIPNL
uniprot id: A0A2K6NFN7
names: Similarity
messages: Belongs to the CARF family.

61622:CAVIN3
gene id: 61622:CAVIN3
uniprot id: A0A2K6NFW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

61622:CSK
gene id: 61622:CSK
uniprot id: A0A2K6RA36
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

61622:IL18R1
gene id: 61622:IL18R1
uniprot id: A0A2K6NKU7
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

61622:KDM4C
gene id: 61622:KDM4C
uniprot id: A0A2K6RPA9
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

61622:CD9
gene id: 61622:CD9
uniprot id: A0A2K6NGI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

61622:RNPC3
gene id: 61622:RNPC3
uniprot id: A0A2K6PIT2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.
messages: Nucleus
messages: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA.

61622:KMT5B
gene id: 61622:KMT5B
uniprot id: A0A2K6RX55
uniprot id: A0A2K6RX76
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

61622:SPATS2L
gene id: 61622:SPATS2L
uniprot id: A0A2K6R376
uniprot id: A0A2K6R3A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPATS2 family.
messages: Cytoplasm

61622:INTS8
gene id: 61622:INTS8
uniprot id: A0A2K6QZQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 8 family.
messages: Nucleus

61622:STON2
gene id: 61622:STON2
uniprot id: A0A2K6N979
uniprot id: A0A2K6N984
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: synaptosome

61622:DCST1
gene id: 61622:DCST1
uniprot id: A0A2K6RGF7
uniprot id: A0A2K6RGK7
names: Subcellular Location Annotation
messages: Membrane

61622:RPS12
gene id: 61622:RPS12
uniprot id: A0A2K6PUZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

61622:STX3
gene id: 61622:STX3
uniprot id: A0A2K6R9S6
uniprot id: A0A2K6R9S7
names: Similarity
messages: Belongs to the syntaxin family.

61622:EGR2
gene id: 61622:EGR2
uniprot id: A0A2K6RC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

61622:PRKAR2B
gene id: 61622:PRKAR2B
uniprot id: A0A2K6R4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

61622:MBOAT4
gene id: 61622:MBOAT4
uniprot id: A0A2K6PV84
names: Subcellular Location Annotation
messages: Membrane

61622:SLC52A1
gene id: 61622:SLC52A1
uniprot id: A0A2K6PH80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

61622:REXO4
gene id: 61622:REXO4
uniprot id: A0A2K6NX40
names: Similarity
messages: Belongs to the REXO4 family.

61622:NME6
gene id: 61622:NME6
uniprot id: A0A2K6NZS1
names: Similarity
messages: Belongs to the NDK family.

61622:MTFMT
gene id: 61622:MTFMT
uniprot id: A0A2K6NNK5
names: Similarity
messages: Belongs to the Fmt family.

61622:MAST1
gene id: 61622:MAST1
uniprot id: A0A2K6R9R9
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

61622:CHRM3
gene id: 61622:CHRM3
uniprot id: A0A2K6NMC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

61622:TMEM256
gene id: 61622:TMEM256
uniprot id: A0A2K6NLP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM256 family.
messages: Membrane

61622:LSM14A
gene id: 61622:LSM14A
uniprot id: A0A2K6QGD8
uniprot id: A0A2K6QGD9
names: Similarity
messages: Belongs to the LSM14 family.

61622:ENOPH1
gene id: 61622:ENOPH1
uniprot id: A0A2K6N9A5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

61622:CD37
gene id: 61622:CD37
uniprot id: A0A2K6QD49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

61622:ENPP2
gene id: 61622:ENPP2
uniprot id: A0A2K6NPY7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Secreted

61622:AIG1
gene id: 61622:AIG1
uniprot id: A0A2K6P118
uniprot id: A0A2K6P130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

61622:BMT2
gene id: 61622:BMT2
uniprot id: A0A2K6PDW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BMT2 family.
messages: Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.
messages: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

61622:INPP5K
gene id: 61622:INPP5K
uniprot id: A0A2K6RH91
names: Similarity
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.

61622:HNRNPAB
gene id: 61622:HNRNPAB
uniprot id: A0A2K6Q4U9
uniprot id: A0A2K6Q4V3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

61622:PAX3
gene id: 61622:PAX3
uniprot id: A0A2K6N9H4
uniprot id: A0A2K6N9H5
uniprot id: A0A2K6N9I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

61622:HSPA4
gene id: 61622:HSPA4
uniprot id: A0A2K6QMF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

61622:GNL2
gene id: 61622:GNL2
uniprot id: A0A2K6NH85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

61622:JUNB
gene id: 61622:JUNB
uniprot id: A0A2K6NQD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

61622:TULP3
gene id: 61622:TULP3
uniprot id: A0A2K6NW94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUB family.
messages: Secreted

61622:UBA6
gene id: 61622:UBA6
uniprot id: A0A2K6PTQ7
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

61622:FLVCR2
gene id: 61622:FLVCR2
uniprot id: A0A2K6RCE0
uniprot id: A0A2K6RCE3
names: Subcellular Location Annotation
messages: Membrane

61622:ATG5
gene id: 61622:ATG5
uniprot id: A0A2K6RC07
uniprot id: A0A2K6RC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

61622:FAM229A
gene id: 61622:FAM229A
uniprot id: A0A2K6R4C9
names: Similarity
messages: Belongs to the FAM229 family.

61622:NLRP3
gene id: 61622:NLRP3
uniprot id: A0A2K6RXV9
names: Similarity
messages: Belongs to the NLRP family.

61622:LOC104664349
gene id: 61622:LOC104664349
uniprot id: A0A2K6NDE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.