608538:HYDTH RS02085
gene id: 608538:HYDTH_RS02085
uniprot id: D3DGC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS07000
gene id: 608538:HYDTH_RS07000
uniprot id: D3DJ37
names: Similarity
messages: Belongs to the histone deacetylase family.

608538:HYDTH RS04900
gene id: 608538:HYDTH_RS04900
uniprot id: D3DHY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

608538:HYDTH RS07095
gene id: 608538:HYDTH_RS07095
uniprot id: D3DJ56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS03670
gene id: 608538:HYDTH_RS03670
uniprot id: D3DH90
names: Similarity
messages: Belongs to the YggT family.

608538:HYDTH RS03585
gene id: 608538:HYDTH_RS03585
uniprot id: D3DH73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

608538:HYDTH RS04390
gene id: 608538:HYDTH_RS04390
uniprot id: D3DHM8
names: Similarity
messages: Belongs to the glutamate synthase family.

608538:HYDTH RS07730
gene id: 608538:HYDTH_RS07730
uniprot id: D3DJI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

608538:HYDTH RS06365
gene id: 608538:HYDTH_RS06365
uniprot id: D3DIR2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS03040
gene id: 608538:HYDTH_RS03040
uniprot id: D3DGW6
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS08695
gene id: 608538:HYDTH_RS08695
uniprot id: D3DK24
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608538:HYDTH RS04275
gene id: 608538:HYDTH_RS04275
uniprot id: D3DHK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

608538:HYDTH RS03910
gene id: 608538:HYDTH_RS03910
uniprot id: D3DHD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

608538:HYDTH RS06095
gene id: 608538:HYDTH_RS06095
uniprot id: D3DIL1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

608538:HYDTH RS03825
gene id: 608538:HYDTH_RS03825
uniprot id: D3DHC0
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

608538:HYDTH RS09490
gene id: 608538:HYDTH_RS09490
uniprot id: D3DKI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

608538:HYDTH RS06090
gene id: 608538:HYDTH_RS06090
uniprot id: D3DIL0
names: Similarity
messages: Belongs to the peptidase S8 family.

608538:HYDTH RS04960
gene id: 608538:HYDTH_RS04960
uniprot id: D3DHZ1
names: Similarity
messages: Belongs to the peptidase U62 family.

608538:HYDTH RS08205
gene id: 608538:HYDTH_RS08205
uniprot id: D3DJS6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS04025
gene id: 608538:HYDTH_RS04025
uniprot id: D3DHG1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

608538:HYDTH RS09260
gene id: 608538:HYDTH_RS09260
uniprot id: D3DKD8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

608538:HYDTH RS07745
gene id: 608538:HYDTH_RS07745
uniprot id: D3DJI6
names: Similarity
messages: Belongs to the polysaccharide synthase family.

608538:HYDTH RS06225
gene id: 608538:HYDTH_RS06225
uniprot id: D3DIN7
names: Similarity
messages: Belongs to the acylphosphatase family.

608538:HYDTH RS00355
gene id: 608538:HYDTH_RS00355
uniprot id: D3DFD4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

608538:HYDTH RS09550
gene id: 608538:HYDTH_RS09550
uniprot id: D3DKJ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

608538:HYDTH RS01595
gene id: 608538:HYDTH_RS01595
uniprot id: D3DG30
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

608538:HYDTH RS07955
gene id: 608538:HYDTH_RS07955
uniprot id: D3DJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

608538:HYDTH RS01850
gene id: 608538:HYDTH_RS01850
uniprot id: D3DG80
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

608538:HYDTH RS07635
gene id: 608538:HYDTH_RS07635
uniprot id: D3DJG4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme c groups covalently per subunit.
messages: C-type diheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c that then channels them into the respiratory electron transport chain. Some electrons may be used for reductive CO(2) fixation.
messages: Cysteine persulfide at Cys-214.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

608538:HYDTH RS00965
gene id: 608538:HYDTH_RS00965
uniprot id: D3DFQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS09455
gene id: 608538:HYDTH_RS09455
uniprot id: D3DKH8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

608538:HYDTH RS05035
gene id: 608538:HYDTH_RS05035
uniprot id: D3DI06
names: Similarity
messages: Belongs to the UPF0166 family.

608538:HYDTH RS05630
gene id: 608538:HYDTH_RS05630
uniprot id: D3DIC6
names: Similarity
messages: Belongs to the P(II) protein family.

608538:HYDTH RS02405
gene id: 608538:HYDTH_RS02405
uniprot id: D3DGI9
names: Similarity
messages: Belongs to the UPF0045 family.

608538:HYDTH RS05690
gene id: 608538:HYDTH_RS05690
uniprot id: D3DID7
names: Similarity
messages: Belongs to the AOR/FOR family.

608538:HYDTH RS05430
gene id: 608538:HYDTH_RS05430
uniprot id: D3DI86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

608538:HYDTH RS06450
gene id: 608538:HYDTH_RS06450
uniprot id: D3DIS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

608538:HYDTH RS03785
gene id: 608538:HYDTH_RS03785
uniprot id: D3DHB2
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

608538:HYDTH RS03745
gene id: 608538:HYDTH_RS03745
uniprot id: D3DHA4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02895
gene id: 608538:HYDTH_RS02895
uniprot id: D3DGT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

608538:HYDTH RS03645
gene id: 608538:HYDTH_RS03645
uniprot id: D3DH85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

608538:HYDTH RS02295
gene id: 608538:HYDTH_RS02295
uniprot id: D3DGG7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

608538:HYDTH RS01685
gene id: 608538:HYDTH_RS01685
uniprot id: D3DG48
names: Similarity
messages: Belongs to the SfsA family.

608538:HYDTH RS06075
gene id: 608538:HYDTH_RS06075
uniprot id: D3DIK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

608538:HYDTH RS01245
gene id: 608538:HYDTH_RS01245
uniprot id: D3DFW0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

608538:HYDTH RS01400
gene id: 608538:HYDTH_RS01400
uniprot id: D3DFZ0
names: Similarity
messages: Belongs to the disproportionating enzyme family.

608538:HYDTH RS08115
gene id: 608538:HYDTH_RS08115
uniprot id: D3DJQ8
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

608538:HYDTH RS07340
gene id: 608538:HYDTH_RS07340
uniprot id: D3DJA5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

608538:HYDTH RS05050
gene id: 608538:HYDTH_RS05050
uniprot id: D3DI09
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

608538:HYDTH RS03575
gene id: 608538:HYDTH_RS03575
uniprot id: D3DH71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

608538:HYDTH RS05785
gene id: 608538:HYDTH_RS05785
uniprot id: D3DIF2
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS06405
gene id: 608538:HYDTH_RS06405
uniprot id: D3DIS0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS06190
gene id: 608538:HYDTH_RS06190
uniprot id: D3DIN0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

608538:HYDTH RS00350
gene id: 608538:HYDTH_RS00350
uniprot id: D3DFD3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

608538:HYDTH RS08715
gene id: 608538:HYDTH_RS08715
uniprot id: D3DK27
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS05710
gene id: 608538:HYDTH_RS05710
uniprot id: D3DIE1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity.

608538:HYDTH RS00375
gene id: 608538:HYDTH_RS00375
uniprot id: D3DFD8
names: Similarity
messages: Belongs to the peptidase C56 family.

608538:HYDTH RS02855
gene id: 608538:HYDTH_RS02855
uniprot id: D3DGS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

608538:HYDTH RS05745
gene id: 608538:HYDTH_RS05745
uniprot id: D3DIE4
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

608538:HYDTH RS04195
gene id: 608538:HYDTH_RS04195
uniprot id: D3DHJ3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

608538:HYDTH RS02660
gene id: 608538:HYDTH_RS02660
uniprot id: D3DGP1
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

608538:HYDTH RS05795
gene id: 608538:HYDTH_RS05795
uniprot id: D3DIF4
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04310
gene id: 608538:HYDTH_RS04310
uniprot id: D3DHL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

608538:HYDTH RS03795
gene id: 608538:HYDTH_RS03795
uniprot id: D3DHB4
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

608538:HYDTH RS08410
gene id: 608538:HYDTH_RS08410
uniprot id: D3DJW9
names: Similarity
messages: Belongs to the PGI/PMI family.

608538:HYDTH RS09060
gene id: 608538:HYDTH_RS09060
uniprot id: D3DK97
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

608538:HYDTH RS09540
gene id: 608538:HYDTH_RS09540
uniprot id: D3DKJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

608538:HYDTH RS06040
gene id: 608538:HYDTH_RS06040
uniprot id: D3DIK0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00285
gene id: 608538:HYDTH_RS00285
uniprot id: D3DFC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

608538:HYDTH RS04110
gene id: 608538:HYDTH_RS04110
uniprot id: D3DHH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

608538:HYDTH RS00405
gene id: 608538:HYDTH_RS00405
uniprot id: D3DFE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

608538:HYDTH RS06330
gene id: 608538:HYDTH_RS06330
uniprot id: D3DIQ8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

608538:HYDTH RS01620
gene id: 608538:HYDTH_RS01620
uniprot id: D3DG34
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

608538:HYDTH RS01275
gene id: 608538:HYDTH_RS01275
uniprot id: D3DFW6
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

608538:HYDTH RS09030
gene id: 608538:HYDTH_RS09030
uniprot id: D3DK91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

608538:HYDTH RS00860
gene id: 608538:HYDTH_RS00860
uniprot id: D3DFN5
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS05290
gene id: 608538:HYDTH_RS05290
uniprot id: D3DI59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS03860
gene id: 608538:HYDTH_RS03860
uniprot id: D3DHC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

608538:HYDTH RS08590
gene id: 608538:HYDTH_RS08590
uniprot id: D3DK05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

608538:HYDTH RS05435
gene id: 608538:HYDTH_RS05435
uniprot id: D3DI87
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS06440
gene id: 608538:HYDTH_RS06440
uniprot id: D3DIS7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

608538:HYDTH RS05750
gene id: 608538:HYDTH_RS05750
uniprot id: D3DIE5
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

608538:HYDTH RS03135
gene id: 608538:HYDTH_RS03135
uniprot id: D3DGY5
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04175
gene id: 608538:HYDTH_RS04175
uniprot id: D3DHI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

608538:HYDTH RS06505
gene id: 608538:HYDTH_RS06505
uniprot id: D3DIT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

608538:HYDTH RS03735
gene id: 608538:HYDTH_RS03735
uniprot id: D3DHA2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS03220
gene id: 608538:HYDTH_RS03220
uniprot id: D3DH01
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

608538:HYDTH RS03620
gene id: 608538:HYDTH_RS03620
uniprot id: D3DH80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

608538:HYDTH RS06875
gene id: 608538:HYDTH_RS06875
uniprot id: D3DJ12
names: Similarity
messages: Belongs to the peptidase S41A family.

608538:HYDTH RS01485
gene id: 608538:HYDTH_RS01485
uniprot id: D3DG08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

608538:HYDTH RS07330
gene id: 608538:HYDTH_RS07330
uniprot id: D3DJA3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS09815
gene id: 608538:HYDTH_RS09815
uniprot id: D3DGM5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

608538:HYDTH RS03750
gene id: 608538:HYDTH_RS03750
uniprot id: D3DHA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

608538:HYDTH RS08935
gene id: 608538:HYDTH_RS08935
uniprot id: D3DK72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS04125
gene id: 608538:HYDTH_RS04125
uniprot id: D3DHH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

608538:HYDTH RS05425
gene id: 608538:HYDTH_RS05425
uniprot id: D3DI84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

608538:HYDTH RS04160
gene id: 608538:HYDTH_RS04160
uniprot id: D3DHI6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

608538:HYDTH RS01195
gene id: 608538:HYDTH_RS01195
uniprot id: D3DFV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

608538:HYDTH RS08985
gene id: 608538:HYDTH_RS08985
uniprot id: D3DK82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS04325
gene id: 608538:HYDTH_RS04325
uniprot id: D3DHL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

608538:HYDTH RS09545
gene id: 608538:HYDTH_RS09545
uniprot id: D3DKJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

608538:HYDTH RS03800
gene id: 608538:HYDTH_RS03800
uniprot id: D3DHB5
names: Similarity
messages: Belongs to the class-I fumarase family.

608538:HYDTH RS03655
gene id: 608538:HYDTH_RS03655
uniprot id: D3DH87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

608538:HYDTH RS04180
gene id: 608538:HYDTH_RS04180
uniprot id: D3DHJ0
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

608538:HYDTH RS03010
gene id: 608538:HYDTH_RS03010
uniprot id: D3DGW0
names: Similarity
messages: Belongs to the UDPGP type 2 family.

608538:HYDTH RS07680
gene id: 608538:HYDTH_RS07680
uniprot id: D3DJH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS09010
gene id: 608538:HYDTH_RS09010
uniprot id: D3DK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

608538:HYDTH RS05590
gene id: 608538:HYDTH_RS05590
uniprot id: D3DIB8
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

608538:HYDTH RS05090
gene id: 608538:HYDTH_RS05090
uniprot id: D3DI17
names: Similarity
messages: Belongs to the peptidase A31 family.

608538:HYDTH RS02400
gene id: 608538:HYDTH_RS02400
uniprot id: D3DGI8
names: Similarity
messages: Belongs to the peptidase S16 family.

608538:HYDTH RS04840
gene id: 608538:HYDTH_RS04840
uniprot id: D3DHX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

608538:HYDTH RS09335
gene id: 608538:HYDTH_RS09335
uniprot id: D3DKF3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

608538:HYDTH RS09220
gene id: 608538:HYDTH_RS09220
uniprot id: D3DKD0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS05055
gene id: 608538:HYDTH_RS05055
uniprot id: D3DI10
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

608538:HYDTH RS01270
gene id: 608538:HYDTH_RS01270
uniprot id: D3DFW5
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

608538:HYDTH RS01130
gene id: 608538:HYDTH_RS01130
uniprot id: D3DFU0
names: Similarity
messages: Belongs to the thioredoxin family.

608538:HYDTH RS08980
gene id: 608538:HYDTH_RS08980
uniprot id: D3DK81
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04405
gene id: 608538:HYDTH_RS04405
uniprot id: D3DHN1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

608538:HYDTH RS00695
gene id: 608538:HYDTH_RS00695
uniprot id: D3DFK1
names: Similarity
messages: Belongs to the MreC family.

608538:HYDTH RS02565
gene id: 608538:HYDTH_RS02565
uniprot id: D3DGM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

608538:HYDTH RS00485
gene id: 608538:HYDTH_RS00485
uniprot id: D3DFG0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

608538:HYDTH RS07670
gene id: 608538:HYDTH_RS07670
uniprot id: D3DJH1
names: Subcellular Location Annotation
messages: Mitochondrion

608538:HYDTH RS01965
gene id: 608538:HYDTH_RS01965
uniprot id: D3DGA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

608538:HYDTH RS02920
gene id: 608538:HYDTH_RS02920
uniprot id: D3DGU2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

608538:HYDTH RS04765
gene id: 608538:HYDTH_RS04765
uniprot id: D3DHV8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

608538:HYDTH RS08030
gene id: 608538:HYDTH_RS08030
uniprot id: D3DJP1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

608538:HYDTH RS08215
gene id: 608538:HYDTH_RS08215
uniprot id: D3DJS8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

608538:HYDTH RS05585
gene id: 608538:HYDTH_RS05585
uniprot id: D3DIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

608538:HYDTH RS03000
gene id: 608538:HYDTH_RS03000
uniprot id: D3DGV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608538:HYDTH RS01905
gene id: 608538:HYDTH_RS01905
uniprot id: D3DG91
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

608538:HYDTH RS01205
gene id: 608538:HYDTH_RS01205
uniprot id: D3DFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

608538:HYDTH RS05285
gene id: 608538:HYDTH_RS05285
uniprot id: D3DI58
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS02440
gene id: 608538:HYDTH_RS02440
uniprot id: D3DGJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS03060
gene id: 608538:HYDTH_RS03060
uniprot id: D3DGX0
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04230
gene id: 608538:HYDTH_RS04230
uniprot id: D3DHK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

608538:HYDTH RS06725
gene id: 608538:HYDTH_RS06725
uniprot id: D3DIY3
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS03675
gene id: 608538:HYDTH_RS03675
uniprot id: D3DH91
names: Similarity
messages: Belongs to the TlyA family.

608538:HYDTH RS03935
gene id: 608538:HYDTH_RS03935
uniprot id: D3DHE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

608538:HYDTH RS06490
gene id: 608538:HYDTH_RS06490
uniprot id: D3DIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

608538:HYDTH RS02165
gene id: 608538:HYDTH_RS02165
uniprot id: D3DGE0
names: Similarity
messages: Belongs to the GSP E family.

608538:HYDTH RS09100
gene id: 608538:HYDTH_RS09100
uniprot id: D3DKA6
names: Similarity
messages: Belongs to the HypD family.

608538:HYDTH RS01845
gene id: 608538:HYDTH_RS01845
uniprot id: D3DG79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

608538:HYDTH RS00885
gene id: 608538:HYDTH_RS00885
uniprot id: D3DFP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

608538:HYDTH RS03250
gene id: 608538:HYDTH_RS03250
uniprot id: D3DH07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

608538:HYDTH RS07970
gene id: 608538:HYDTH_RS07970
uniprot id: D3DJN0
names: Similarity
messages: Belongs to the P(II) protein family.

608538:HYDTH RS04100
gene id: 608538:HYDTH_RS04100
uniprot id: D3DHH6
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.

608538:HYDTH RS08660
gene id: 608538:HYDTH_RS08660
uniprot id: D3DK17
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS01795
gene id: 608538:HYDTH_RS01795
uniprot id: D3DG69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

608538:HYDTH RS05975
gene id: 608538:HYDTH_RS05975
uniprot id: D3DII6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer and homodimer.

608538:HYDTH RS05470
gene id: 608538:HYDTH_RS05470
uniprot id: D3DI94
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

608538:HYDTH RS03810
gene id: 608538:HYDTH_RS03810
uniprot id: D3DHB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

608538:HYDTH RS07165
gene id: 608538:HYDTH_RS07165
uniprot id: D3DJ70
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

608538:HYDTH RS08250
gene id: 608538:HYDTH_RS08250
uniprot id: D3DJT5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

608538:HYDTH RS03775
gene id: 608538:HYDTH_RS03775
uniprot id: D3DHB0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

608538:HYDTH RS07585
gene id: 608538:HYDTH_RS07585
uniprot id: D3DJF5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

608538:HYDTH RS02975
gene id: 608538:HYDTH_RS02975
uniprot id: D3DGV3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

608538:HYDTH RS05535
gene id: 608538:HYDTH_RS05535
uniprot id: D3DIA7
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04320
gene id: 608538:HYDTH_RS04320
uniprot id: D3DHL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

608538:HYDTH RS04235
gene id: 608538:HYDTH_RS04235
uniprot id: D3DHK1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

608538:HYDTH RS06285
gene id: 608538:HYDTH_RS06285
uniprot id: D3DIP9
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

608538:HYDTH RS00595
gene id: 608538:HYDTH_RS00595
uniprot id: D3DFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

608538:HYDTH RS08420
gene id: 608538:HYDTH_RS08420
uniprot id: D3DJX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

608538:HYDTH RS02910
gene id: 608538:HYDTH_RS02910
uniprot id: D3DGU0
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

608538:HYDTH RS02080
gene id: 608538:HYDTH_RS02080
uniprot id: D3DGC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

608538:HYDTH RS01880
gene id: 608538:HYDTH_RS01880
uniprot id: D3DG86
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

608538:HYDTH RS02980
gene id: 608538:HYDTH_RS02980
uniprot id: D3DGV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS00250
gene id: 608538:HYDTH_RS00250
uniprot id: D3DFB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS06545
gene id: 608538:HYDTH_RS06545
uniprot id: D3DIU7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02930
gene id: 608538:HYDTH_RS02930
uniprot id: D3DGU4
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04130
gene id: 608538:HYDTH_RS04130
uniprot id: D3DHI0
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

608538:HYDTH RS03480
gene id: 608538:HYDTH_RS03480
uniprot id: D3DH51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

608538:HYDTH RS06885
gene id: 608538:HYDTH_RS06885
uniprot id: D3DJ14
names: Similarity
messages: Belongs to the Nudix hydrolase family.

608538:HYDTH RS08185
gene id: 608538:HYDTH_RS08185
uniprot id: D3DJS2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

608538:HYDTH RS08270
gene id: 608538:HYDTH_RS08270
uniprot id: D3DJT9
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

608538:HYDTH RS05595
gene id: 608538:HYDTH_RS05595
uniprot id: D3DIB9
names: Similarity
messages: Belongs to the P(II) protein family.

608538:HYDTH RS09225
gene id: 608538:HYDTH_RS09225
uniprot id: D3DKD1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS08520
gene id: 608538:HYDTH_RS08520
uniprot id: D3DJZ2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

608538:HYDTH RS00720
gene id: 608538:HYDTH_RS00720
uniprot id: D3DFK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

608538:HYDTH RS03150
gene id: 608538:HYDTH_RS03150
uniprot id: D3DGY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

608538:HYDTH RS01660
gene id: 608538:HYDTH_RS01660
uniprot id: D3DG42
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

608538:HYDTH RS00135
gene id: 608538:HYDTH_RS00135
uniprot id: D3DF90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

608538:HYDTH RS09350
gene id: 608538:HYDTH_RS09350
uniprot id: D3DKF7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608538:HYDTH RS00555
gene id: 608538:HYDTH_RS00555
uniprot id: D3DFH4
names: Similarity
messages: Belongs to the TrpC family.

608538:HYDTH RS01580
gene id: 608538:HYDTH_RS01580
uniprot id: D3DG27
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00140
gene id: 608538:HYDTH_RS00140
uniprot id: D3DF91
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00360
gene id: 608538:HYDTH_RS00360
uniprot id: D3DFD5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

608538:HYDTH RS07705
gene id: 608538:HYDTH_RS07705
uniprot id: D3DJH8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

608538:HYDTH RS00705
gene id: 608538:HYDTH_RS00705
uniprot id: D3DFK3
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

608538:HYDTH RS04290
gene id: 608538:HYDTH_RS04290
uniprot id: D3DHL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

608538:HYDTH RS06610
gene id: 608538:HYDTH_RS06610
uniprot id: D3DIW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

608538:HYDTH RS04250
gene id: 608538:HYDTH_RS04250
uniprot id: D3DHK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

608538:HYDTH RS00275
gene id: 608538:HYDTH_RS00275
uniprot id: D3DFB8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

608538:HYDTH RS03080
gene id: 608538:HYDTH_RS03080
uniprot id: D3DGX4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

608538:HYDTH RS01710
gene id: 608538:HYDTH_RS01710
uniprot id: D3DG53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

608538:HYDTH RS06205
gene id: 608538:HYDTH_RS06205
uniprot id: D3DIN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

608538:HYDTH RS06185
gene id: 608538:HYDTH_RS06185
uniprot id: D3DIM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

608538:HYDTH RS00855
gene id: 608538:HYDTH_RS00855
uniprot id: D3DFN4
names: Similarity
messages: Belongs to the UbiD family.

608538:HYDTH RS07640
gene id: 608538:HYDTH_RS07640
uniprot id: D3DJG5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SoxA family.
messages: Binds 2 heme c groups covalently per subunit.
messages: C-type diheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c that then channels them into the respiratory electron transport chain. Some electrons may be used for reductive CO(2) fixation.
messages: Cysteine persulfide at Cys-220.
messages: Heterodimer of SoxA and SoxX.
messages: Periplasm

608538:HYDTH RS01445
gene id: 608538:HYDTH_RS01445
uniprot id: D3DG00
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS06465
gene id: 608538:HYDTH_RS06465
uniprot id: D3DIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family. GSP D subfamily.
messages: Cell outer membrane

608538:HYDTH RS03185
gene id: 608538:HYDTH_RS03185
uniprot id: D3DGZ4
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00255
gene id: 608538:HYDTH_RS00255
uniprot id: D3DFB4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

608538:HYDTH RS04660
gene id: 608538:HYDTH_RS04660
uniprot id: D3DHT7
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

608538:HYDTH RS06350
gene id: 608538:HYDTH_RS06350
uniprot id: D3DIR0
names: Similarity
messages: Belongs to the sigma-54 factor family.

608538:HYDTH RS03065
gene id: 608538:HYDTH_RS03065
uniprot id: D3DGX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

608538:HYDTH RS06315
gene id: 608538:HYDTH_RS06315
uniprot id: D3DIQ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS03600
gene id: 608538:HYDTH_RS03600
uniprot id: D3DH76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

608538:HYDTH RS05020
gene id: 608538:HYDTH_RS05020
uniprot id: D3DI03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

608538:HYDTH RS02095
gene id: 608538:HYDTH_RS02095
uniprot id: D3DGC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS00340
gene id: 608538:HYDTH_RS00340
uniprot id: D3DFD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

608538:HYDTH RS04075
gene id: 608538:HYDTH_RS04075
uniprot id: D3DHH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

608538:HYDTH RS01920
gene id: 608538:HYDTH_RS01920
uniprot id: D3DG94
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

608538:HYDTH RS04815
gene id: 608538:HYDTH_RS04815
uniprot id: D3DHW7
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00225
gene id: 608538:HYDTH_RS00225
uniprot id: D3DFA8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

608538:HYDTH RS08680
gene id: 608538:HYDTH_RS08680
uniprot id: D3DK21
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

608538:HYDTH RS08975
gene id: 608538:HYDTH_RS08975
uniprot id: D3DK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

608538:HYDTH RS02060
gene id: 608538:HYDTH_RS02060
uniprot id: D3DGB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS06945
gene id: 608538:HYDTH_RS06945
uniprot id: D3DJ25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

608538:HYDTH RS09305
gene id: 608538:HYDTH_RS09305
uniprot id: D3DKE7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

608538:HYDTH RS07760
gene id: 608538:HYDTH_RS07760
uniprot id: D3DJI9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

608538:HYDTH RS03540
gene id: 608538:HYDTH_RS03540
uniprot id: D3DH63
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

608538:HYDTH RS06275
gene id: 608538:HYDTH_RS06275
uniprot id: D3DIP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

608538:HYDTH RS01510
gene id: 608538:HYDTH_RS01510
uniprot id: D3DG13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

608538:HYDTH RS08245
gene id: 608538:HYDTH_RS08245
uniprot id: D3DJT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS04260
gene id: 608538:HYDTH_RS04260
uniprot id: D3DHK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

608538:HYDTH RS04865
gene id: 608538:HYDTH_RS04865
uniprot id: D3DHX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS05370
gene id: 608538:HYDTH_RS05370
uniprot id: D3DI73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

608538:HYDTH RS02090
gene id: 608538:HYDTH_RS02090
uniprot id: D3DGC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS06050
gene id: 608538:HYDTH_RS06050
uniprot id: D3DIK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

608538:HYDTH RS07510
gene id: 608538:HYDTH_RS07510
uniprot id: D3DJE0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02345
gene id: 608538:HYDTH_RS02345
uniprot id: D3DGH7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

608538:HYDTH RS00465
gene id: 608538:HYDTH_RS00465
uniprot id: D3DFF6
names: Similarity
messages: Belongs to the arsA ATPase family.

608538:HYDTH RS08445
gene id: 608538:HYDTH_RS08445
uniprot id: D3DJX6
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

608538:HYDTH RS06370
gene id: 608538:HYDTH_RS06370
uniprot id: D3DIR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

608538:HYDTH RS03650
gene id: 608538:HYDTH_RS03650
uniprot id: D3DH86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

608538:HYDTH RS07475
gene id: 608538:HYDTH_RS07475
uniprot id: D3DJD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

608538:HYDTH RS04335
gene id: 608538:HYDTH_RS04335
uniprot id: D3DHM1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

608538:HYDTH RS02475
gene id: 608538:HYDTH_RS02475
uniprot id: D3DGK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

608538:HYDTH RS02995
gene id: 608538:HYDTH_RS02995
uniprot id: D3DGV7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

608538:HYDTH RS07765
gene id: 608538:HYDTH_RS07765
uniprot id: D3DJJ0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

608538:HYDTH RS02070
gene id: 608538:HYDTH_RS02070
uniprot id: D3DGC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS07310
gene id: 608538:HYDTH_RS07310
uniprot id: D3DJ99
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

608538:HYDTH RS07415
gene id: 608538:HYDTH_RS07415
uniprot id: D3DJC0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS08570
gene id: 608538:HYDTH_RS08570
uniprot id: D3DK01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

608538:HYDTH RS00615
gene id: 608538:HYDTH_RS00615
uniprot id: D3DFI5
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

608538:HYDTH RS08120
gene id: 608538:HYDTH_RS08120
uniprot id: D3DJQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

608538:HYDTH RS08000
gene id: 608538:HYDTH_RS08000
uniprot id: D3DJN6
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS09585
gene id: 608538:HYDTH_RS09585
uniprot id: D3DKK3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02025
gene id: 608538:HYDTH_RS02025
uniprot id: D3DGB2
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS07855
gene id: 608538:HYDTH_RS07855
uniprot id: D3DJK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

608538:HYDTH RS03765
gene id: 608538:HYDTH_RS03765
uniprot id: D3DHA8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

608538:HYDTH RS07550
gene id: 608538:HYDTH_RS07550
uniprot id: D3DJE8
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04340
gene id: 608538:HYDTH_RS04340
uniprot id: D3DHM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

608538:HYDTH RS03500
gene id: 608538:HYDTH_RS03500
uniprot id: D3DH55
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

608538:HYDTH RS07195
gene id: 608538:HYDTH_RS07195
uniprot id: D3DJ76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

608538:HYDTH RS03465
gene id: 608538:HYDTH_RS03465
uniprot id: D3DH48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

608538:HYDTH RS06820
gene id: 608538:HYDTH_RS06820
uniprot id: D3DJ01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

608538:HYDTH RS05830
gene id: 608538:HYDTH_RS05830
uniprot id: D3DIG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

608538:HYDTH RS06540
gene id: 608538:HYDTH_RS06540
uniprot id: D3DIU6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

608538:HYDTH RS07880
gene id: 608538:HYDTH_RS07880
uniprot id: D3DJL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

608538:HYDTH RS00585
gene id: 608538:HYDTH_RS00585
uniprot id: D3DFH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

608538:HYDTH RS01050
gene id: 608538:HYDTH_RS01050
uniprot id: D3DFS4
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Ahb/Nir family.
messages: H.thermophilus possesses the fused nirDL gene but lacks the genes encoding NirG and NirH.
messages: Involved in heme d1 biosynthesis. Catalyzes the decarboxylation of siroheme into didecarboxysiroheme. Siroheme is probably decarboxylated to monodecarboxysiroheme, which is in turn decarboxylated to didecarboxysiroheme.

608538:HYDTH RS06385
gene id: 608538:HYDTH_RS06385
uniprot id: D3DIR6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

608538:HYDTH RS05005
gene id: 608538:HYDTH_RS05005
uniprot id: D3DI00
names: Similarity
messages: Belongs to the peptidase C40 family.

608538:HYDTH RS09050
gene id: 608538:HYDTH_RS09050
uniprot id: D3DK95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

608538:HYDTH RS01915
gene id: 608538:HYDTH_RS01915
uniprot id: D3DG93
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.

608538:HYDTH RS05920
gene id: 608538:HYDTH_RS05920
uniprot id: D3DIH7
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

608538:HYDTH RS06235
gene id: 608538:HYDTH_RS06235
uniprot id: D3DIN9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

608538:HYDTH RS04745
gene id: 608538:HYDTH_RS04745
uniprot id: D3DHV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS01175
gene id: 608538:HYDTH_RS01175
uniprot id: D3DFV0
names: Similarity
messages: Belongs to the MEMO1 family.

608538:HYDTH RS02525
gene id: 608538:HYDTH_RS02525
uniprot id: D3DGL3
names: Subcellular Location Annotation
messages: Cytoplasm

608538:HYDTH RS03985
gene id: 608538:HYDTH_RS03985
uniprot id: D3DHF3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

608538:HYDTH RS08255
gene id: 608538:HYDTH_RS08255
uniprot id: D3DJT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

608538:HYDTH RS06115
gene id: 608538:HYDTH_RS06115
uniprot id: D3DIL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. PqqE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
messages: Interacts with PqqD. The interaction is necessary for activity of PqqE.

608538:HYDTH RS04710
gene id: 608538:HYDTH_RS04710
uniprot id: D3DHU6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

608538:HYDTH RS09590
gene id: 608538:HYDTH_RS09590
uniprot id: D3DKK4
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

608538:HYDTH RS08110
gene id: 608538:HYDTH_RS08110
uniprot id: D3DJQ7
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS07590
gene id: 608538:HYDTH_RS07590
uniprot id: D3DJF6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

608538:HYDTH RS04315
gene id: 608538:HYDTH_RS04315
uniprot id: D3DHL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

608538:HYDTH RS02250
gene id: 608538:HYDTH_RS02250
uniprot id: D3DGF8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

608538:HYDTH RS03325
gene id: 608538:HYDTH_RS03325
uniprot id: D3DH22
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS03435
gene id: 608538:HYDTH_RS03435
uniprot id: D3DH42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

608538:HYDTH RS00080
gene id: 608538:HYDTH_RS00080
uniprot id: D3DF78
names: Similarity
messages: Belongs to the phosphohexose mutase family.

608538:HYDTH RS03720
gene id: 608538:HYDTH_RS03720
uniprot id: D3DHA0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

608538:HYDTH RS01855
gene id: 608538:HYDTH_RS01855
uniprot id: D3DG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

608538:HYDTH RS07395
gene id: 608538:HYDTH_RS07395
uniprot id: D3DJB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

608538:HYDTH RS08515
gene id: 608538:HYDTH_RS08515
uniprot id: D3DJZ0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

608538:HYDTH RS01875
gene id: 608538:HYDTH_RS01875
uniprot id: D3DG85
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS08400
gene id: 608538:HYDTH_RS08400
uniprot id: D3DJW7
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

608538:HYDTH RS00525
gene id: 608538:HYDTH_RS00525
uniprot id: D3DFG8
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity is not inhibited by EDTA in vitro, nor enhanced by the addition of Mg(2+).
messages: Belongs to the histidine phosphatase superfamily. Metal-independent phosphoserine phosphatase family.
messages: Catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity.
messages: Homodimer. Can also form a heterodimer with PspB.

608538:HYDTH RS04730
gene id: 608538:HYDTH_RS04730
uniprot id: D3DHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

608538:HYDTH RS07595
gene id: 608538:HYDTH_RS07595
uniprot id: D3DJF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

608538:HYDTH RS03475
gene id: 608538:HYDTH_RS03475
uniprot id: D3DH50
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00500
gene id: 608538:HYDTH_RS00500
uniprot id: D3DFG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00880
gene id: 608538:HYDTH_RS00880
uniprot id: D3DFN9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS06935
gene id: 608538:HYDTH_RS06935
uniprot id: D3DJ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

608538:HYDTH RS09495
gene id: 608538:HYDTH_RS09495
uniprot id: D3DKI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

608538:HYDTH RS03660
gene id: 608538:HYDTH_RS03660
uniprot id: D3DH88
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

608538:HYDTH RS07260
gene id: 608538:HYDTH_RS07260
uniprot id: D3DJ88
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

608538:HYDTH RS04030
gene id: 608538:HYDTH_RS04030
uniprot id: D3DHG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

608538:HYDTH RS08550
gene id: 608538:HYDTH_RS08550
uniprot id: D3DJZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

608538:HYDTH RS06500
gene id: 608538:HYDTH_RS06500
uniprot id: D3DIT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

608538:HYDTH RS05095
gene id: 608538:HYDTH_RS05095
uniprot id: D3DI18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HupC/HyaC/HydC family.
messages: Membrane

608538:HYDTH RS08020
gene id: 608538:HYDTH_RS08020
uniprot id: D3DJN9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS08160
gene id: 608538:HYDTH_RS08160
uniprot id: D3DJR7
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

608538:HYDTH RS08060
gene id: 608538:HYDTH_RS08060
uniprot id: D3DJP7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

608538:HYDTH RS06200
gene id: 608538:HYDTH_RS06200
uniprot id: D3DIN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02365
gene id: 608538:HYDTH_RS02365
uniprot id: D3DGI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

608538:HYDTH RS07650
gene id: 608538:HYDTH_RS07650
uniprot id: D3DJG7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

608538:HYDTH RS08795
gene id: 608538:HYDTH_RS08795
uniprot id: D3DK43
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

608538:HYDTH RS09195
gene id: 608538:HYDTH_RS09195
uniprot id: D3DKC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

608538:HYDTH RS05355
gene id: 608538:HYDTH_RS05355
uniprot id: D3DI71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

608538:HYDTH RS05260
gene id: 608538:HYDTH_RS05260
uniprot id: D3DI53
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

608538:HYDTH RS09330
gene id: 608538:HYDTH_RS09330
uniprot id: D3DKF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

608538:HYDTH RS01020
gene id: 608538:HYDTH_RS01020
uniprot id: D3DFR8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

608538:HYDTH RS06705
gene id: 608538:HYDTH_RS06705
uniprot id: D3DIX9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

608538:HYDTH RS03125
gene id: 608538:HYDTH_RS03125
uniprot id: D3DGY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608538:HYDTH RS06080
gene id: 608538:HYDTH_RS06080
uniprot id: D3DIK8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

608538:HYDTH RS04795
gene id: 608538:HYDTH_RS04795
uniprot id: D3DHW4
names: Function
names: Similarity
messages: Belongs to the ATPase gamma chain family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

608538:HYDTH RS00445
gene id: 608538:HYDTH_RS00445
uniprot id: D3DFF2
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

608538:HYDTH RS08430
gene id: 608538:HYDTH_RS08430
uniprot id: D3DJX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

608538:HYDTH RS00435
gene id: 608538:HYDTH_RS00435
uniprot id: D3DFF0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

608538:HYDTH RS07450
gene id: 608538:HYDTH_RS07450
uniprot id: D3DJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

608538:HYDTH RS00155
gene id: 608538:HYDTH_RS00155
uniprot id: D3DF94
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

608538:HYDTH RS06380
gene id: 608538:HYDTH_RS06380
uniprot id: D3DIR5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

608538:HYDTH RS05215
gene id: 608538:HYDTH_RS05215
uniprot id: D3DI44
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

608538:HYDTH RS01390
gene id: 608538:HYDTH_RS01390
uniprot id: D3DFY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

608538:HYDTH RS03390
gene id: 608538:HYDTH_RS03390
uniprot id: D3DH34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

608538:HYDTH RS00235
gene id: 608538:HYDTH_RS00235
uniprot id: D3DFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS03555
gene id: 608538:HYDTH_RS03555
uniprot id: D3DH67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

608538:HYDTH RS09290
gene id: 608538:HYDTH_RS09290
uniprot id: D3DKE4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

608538:HYDTH RS04245
gene id: 608538:HYDTH_RS04245
uniprot id: D3DHK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

608538:HYDTH RS09295
gene id: 608538:HYDTH_RS09295
uniprot id: D3DKE5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

608538:HYDTH RS06595
gene id: 608538:HYDTH_RS06595
uniprot id: D3DIV7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00985
gene id: 608538:HYDTH_RS00985
uniprot id: D3DFR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

608538:HYDTH RS01355
gene id: 608538:HYDTH_RS01355
uniprot id: D3DFY1
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

608538:HYDTH RS00610
gene id: 608538:HYDTH_RS00610
uniprot id: D3DFI4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

608538:HYDTH RS08940
gene id: 608538:HYDTH_RS08940
uniprot id: D3DK73
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608538:HYDTH RS05375
gene id: 608538:HYDTH_RS05375
uniprot id: D3DI74
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

608538:HYDTH RS07910
gene id: 608538:HYDTH_RS07910
uniprot id: D3DJL9
names: Similarity
messages: Belongs to the ClpA/ClpB family.

608538:HYDTH RS09025
gene id: 608538:HYDTH_RS09025
uniprot id: D3DK90
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS08895
gene id: 608538:HYDTH_RS08895
uniprot id: D3DK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

608538:HYDTH RS02300
gene id: 608538:HYDTH_RS02300
uniprot id: D3DGG8
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

608538:HYDTH RS07430
gene id: 608538:HYDTH_RS07430
uniprot id: D3DJC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

608538:HYDTH RS03130
gene id: 608538:HYDTH_RS03130
uniprot id: D3DGY4
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

608538:HYDTH RS07255
gene id: 608538:HYDTH_RS07255
uniprot id: D3DJ87
names: Similarity
messages: Belongs to the Fur family.

608538:HYDTH RS07725
gene id: 608538:HYDTH_RS07725
uniprot id: D3DJI2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

608538:HYDTH RS00840
gene id: 608538:HYDTH_RS00840
uniprot id: D3DFN1
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

608538:HYDTH RS08460
gene id: 608538:HYDTH_RS08460
uniprot id: D3DJX9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

608538:HYDTH RS07950
gene id: 608538:HYDTH_RS07950
uniprot id: D3DJM6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608538:HYDTH RS00330
gene id: 608538:HYDTH_RS00330
uniprot id: D3DFC9
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS08805
gene id: 608538:HYDTH_RS08805
uniprot id: D3DK45
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00025
gene id: 608538:HYDTH_RS00025
uniprot id: D3DF69
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

608538:HYDTH RS07905
gene id: 608538:HYDTH_RS07905
uniprot id: D3DJL8
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

608538:HYDTH RS07370
gene id: 608538:HYDTH_RS07370
uniprot id: D3DJB2
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS02220
gene id: 608538:HYDTH_RS02220
uniprot id: D3DGF2
names: Similarity
messages: Belongs to the aspartokinase family.

608538:HYDTH RS02515
gene id: 608538:HYDTH_RS02515
uniprot id: D3DGL1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

608538:HYDTH RS06630
gene id: 608538:HYDTH_RS06630
uniprot id: D3DIW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably interacts with PlsX.

608538:HYDTH RS03605
gene id: 608538:HYDTH_RS03605
uniprot id: D3DH77
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

608538:HYDTH RS07305
gene id: 608538:HYDTH_RS07305
uniprot id: D3DJ97
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

608538:HYDTH RS07060
gene id: 608538:HYDTH_RS07060
uniprot id: D3DJ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

608538:HYDTH RS02465
gene id: 608538:HYDTH_RS02465
uniprot id: D3DGK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

608538:HYDTH RS01630
gene id: 608538:HYDTH_RS01630
uniprot id: D3DG36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

608538:HYDTH RS02330
gene id: 608538:HYDTH_RS02330
uniprot id: D3DGH4
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS06635
gene id: 608538:HYDTH_RS06635
uniprot id: D3DIW5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

608538:HYDTH RS09065
gene id: 608538:HYDTH_RS09065
uniprot id: D3DK98
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

608538:HYDTH RS06420
gene id: 608538:HYDTH_RS06420
uniprot id: D3DIS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

608538:HYDTH RS06815
gene id: 608538:HYDTH_RS06815
uniprot id: D3DJ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbC subfamily.
messages: Periplasm

608538:HYDTH RS07965
gene id: 608538:HYDTH_RS07965
uniprot id: D3DJM9
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS03965
gene id: 608538:HYDTH_RS03965
uniprot id: D3DHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

608538:HYDTH RS03940
gene id: 608538:HYDTH_RS03940
uniprot id: D3DHE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

608538:HYDTH RS01825
gene id: 608538:HYDTH_RS01825
uniprot id: D3DG75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

608538:HYDTH RS08900
gene id: 608538:HYDTH_RS08900
uniprot id: D3DK65
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

608538:HYDTH RS07425
gene id: 608538:HYDTH_RS07425
uniprot id: D3DJC2
names: Similarity
messages: Belongs to the peptidase C40 family.

608538:HYDTH RS00070
gene id: 608538:HYDTH_RS00070
uniprot id: D3DF76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

608538:HYDTH RS02100
gene id: 608538:HYDTH_RS02100
uniprot id: D3DGC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

608538:HYDTH RS08545
gene id: 608538:HYDTH_RS08545
uniprot id: D3DJZ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

608538:HYDTH RS01325
gene id: 608538:HYDTH_RS01325
uniprot id: D3DFX6
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

608538:HYDTH RS03470
gene id: 608538:HYDTH_RS03470
uniprot id: D3DH49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

608538:HYDTH RS00960
gene id: 608538:HYDTH_RS00960
uniprot id: D3DFQ6
names: Similarity
messages: Belongs to the TrpF family.

608538:HYDTH RS06555
gene id: 608538:HYDTH_RS06555
uniprot id: D3DIU9
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

608538:HYDTH RS00940
gene id: 608538:HYDTH_RS00940
uniprot id: D3DFQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

608538:HYDTH RS04225
gene id: 608538:HYDTH_RS04225
uniprot id: D3DHJ9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

608538:HYDTH RS07980
gene id: 608538:HYDTH_RS07980
uniprot id: D3DJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS09090
gene id: 608538:HYDTH_RS09090
uniprot id: D3DKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

608538:HYDTH RS03090
gene id: 608538:HYDTH_RS03090
uniprot id: D3DGX6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

608538:HYDTH RS06485
gene id: 608538:HYDTH_RS06485
uniprot id: D3DIT5
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS07505
gene id: 608538:HYDTH_RS07505
uniprot id: D3DJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

608538:HYDTH RS01715
gene id: 608538:HYDTH_RS01715
uniprot id: D3DG54
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS07600
gene id: 608538:HYDTH_RS07600
uniprot id: D3DJF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

608538:HYDTH RS09655
gene id: 608538:HYDTH_RS09655
uniprot id: D3DFH8
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

608538:HYDTH RS03195
gene id: 608538:HYDTH_RS03195
uniprot id: D3DGZ6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

608538:HYDTH RS01000
gene id: 608538:HYDTH_RS01000
uniprot id: D3DFR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

608538:HYDTH RS00065
gene id: 608538:HYDTH_RS00065
uniprot id: D3DF75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

608538:HYDTH RS09210
gene id: 608538:HYDTH_RS09210
uniprot id: D3DKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

608538:HYDTH RS03665
gene id: 608538:HYDTH_RS03665
uniprot id: D3DH89
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

608538:HYDTH RS05315
gene id: 608538:HYDTH_RS05315
uniprot id: D3DI63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS01420
gene id: 608538:HYDTH_RS01420
uniprot id: D3DFZ5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

608538:HYDTH RS00530
gene id: 608538:HYDTH_RS00530
uniprot id: D2Z0H9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

608538:HYDTH RS06950
gene id: 608538:HYDTH_RS06950
uniprot id: D3DJ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

608538:HYDTH RS08905
gene id: 608538:HYDTH_RS08905
uniprot id: D3DK66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

608538:HYDTH RS02415
gene id: 608538:HYDTH_RS02415
uniprot id: D3DGJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

608538:HYDTH RS01345
gene id: 608538:HYDTH_RS01345
uniprot id: D3DFX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

608538:HYDTH RS02130
gene id: 608538:HYDTH_RS02130
uniprot id: D3DGD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

608538:HYDTH RS05530
gene id: 608538:HYDTH_RS05530
uniprot id: D3DIA6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

608538:HYDTH RS00385
gene id: 608538:HYDTH_RS00385
uniprot id: D3DFE0
names: Similarity
messages: Belongs to the CutA family.

608538:HYDTH RS04115
gene id: 608538:HYDTH_RS04115
uniprot id: D3DHH8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

608538:HYDTH RS08675
gene id: 608538:HYDTH_RS08675
uniprot id: D3DK20
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

608538:HYDTH RS09385
gene id: 608538:HYDTH_RS09385
uniprot id: D3DKG4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

608538:HYDTH RS09165
gene id: 608538:HYDTH_RS09165
uniprot id: D3DKB9
names: Similarity
messages: Belongs to the GSP E family.

608538:HYDTH RS04375
gene id: 608538:HYDTH_RS04375
uniprot id: D3DHM6
names: Similarity
messages: Belongs to the LacAB/RpiB family.

608538:HYDTH RS02905
gene id: 608538:HYDTH_RS02905
uniprot id: D3DGT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

608538:HYDTH RS00120
gene id: 608538:HYDTH_RS00120
uniprot id: D3DF87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

608538:HYDTH RS06215
gene id: 608538:HYDTH_RS06215
uniprot id: D3DIN5
names: Similarity
names: Subunit
messages: Belongs to the RusA family.
messages: Homodimer.

608538:HYDTH RS01890
gene id: 608538:HYDTH_RS01890
uniprot id: D3DG88
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

608538:HYDTH RS06140
gene id: 608538:HYDTH_RS06140
uniprot id: D3DIM0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

608538:HYDTH RS02455
gene id: 608538:HYDTH_RS02455
uniprot id: D3DGJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS00725
gene id: 608538:HYDTH_RS00725
uniprot id: D3DFK7
names: Similarity
messages: Belongs to the archease family.

608538:HYDTH RS00125
gene id: 608538:HYDTH_RS00125
uniprot id: D3DF88
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS04355
gene id: 608538:HYDTH_RS04355
uniprot id: D3DHL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

608538:HYDTH RS06530
gene id: 608538:HYDTH_RS06530
uniprot id: D3DIU4
names: Similarity
messages: Belongs to the RecJ family.

608538:HYDTH RS07440
gene id: 608538:HYDTH_RS07440
uniprot id: D3DJC5
names: Similarity
messages: Belongs to the SCO1/2 family.

608538:HYDTH RS03350
gene id: 608538:HYDTH_RS03350
uniprot id: D3DH26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

608538:HYDTH RS05105
gene id: 608538:HYDTH_RS05105
uniprot id: D3DI20
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

608538:HYDTH RS03695
gene id: 608538:HYDTH_RS03695
uniprot id: D3DH95
names: Similarity
messages: Belongs to the peptidase S26 family.

608538:HYDTH RS04020
gene id: 608538:HYDTH_RS04020
uniprot id: D3DHG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

608538:HYDTH RS03615
gene id: 608538:HYDTH_RS03615
uniprot id: D3DH79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

608538:HYDTH RS06970
gene id: 608538:HYDTH_RS06970
uniprot id: D3DJ31
names: Similarity
messages: Belongs to the MoaD family.

608538:HYDTH RS04665
gene id: 608538:HYDTH_RS04665
uniprot id: D3DHT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

608538:HYDTH RS08890
gene id: 608538:HYDTH_RS08890
uniprot id: D3DK63
names: Similarity
messages: Belongs to the SAICAR synthetase family.

608538:HYDTH RS03495
gene id: 608538:HYDTH_RS03495
uniprot id: D3DH54
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS08165
gene id: 608538:HYDTH_RS08165
uniprot id: D3DJR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

608538:HYDTH RS08595
gene id: 608538:HYDTH_RS08595
uniprot id: D3DK06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608538:HYDTH RS01030
gene id: 608538:HYDTH_RS01030
uniprot id: D3DFS0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

608538:HYDTH RS01295
gene id: 608538:HYDTH_RS01295
uniprot id: D3DFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

608538:HYDTH RS07445
gene id: 608538:HYDTH_RS07445
uniprot id: D3DJC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

608538:HYDTH RS06015
gene id: 608538:HYDTH_RS06015
uniprot id: D3DIJ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

608538:HYDTH RS09505
gene id: 608538:HYDTH_RS09505
uniprot id: Q75VW3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

608538:HYDTH RS02030
gene id: 608538:HYDTH_RS02030
uniprot id: D3DGB3
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS08440
gene id: 608538:HYDTH_RS08440
uniprot id: D3DJX5
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

608538:HYDTH RS00835
gene id: 608538:HYDTH_RS00835
uniprot id: D3DFN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

608538:HYDTH RS04975
gene id: 608538:HYDTH_RS04975
uniprot id: P15452
names: Function
names: PTM
names: Similarity
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Reacts with hydrogenase.

608538:HYDTH RS07210
gene id: 608538:HYDTH_RS07210
uniprot id: D3DJ79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

608538:HYDTH RS04270
gene id: 608538:HYDTH_RS04270
uniprot id: D3DHK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

608538:HYDTH RS03255
gene id: 608538:HYDTH_RS03255
uniprot id: D3DH08
names: Similarity
messages: Belongs to the NusB family.

608538:HYDTH RS06685
gene id: 608538:HYDTH_RS06685
uniprot id: D3DIX6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

608538:HYDTH RS05755
gene id: 608538:HYDTH_RS05755
uniprot id: D3DIE6
names: Similarity
messages: Belongs to the NifX/NifY family.

608538:HYDTH RS03425
gene id: 608538:HYDTH_RS03425
uniprot id: D3DH40
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

608538:HYDTH RS01125
gene id: 608538:HYDTH_RS01125
uniprot id: D3DFT9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

608538:HYDTH RS08800
gene id: 608538:HYDTH_RS08800
uniprot id: D3DK44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02150
gene id: 608538:HYDTH_RS02150
uniprot id: D3DGD7
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS09580
gene id: 608538:HYDTH_RS09580
uniprot id: D3DKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

608538:HYDTH RS08050
gene id: 608538:HYDTH_RS08050
uniprot id: D3DJP5
names: Similarity
messages: Belongs to the hemerythrin family.

608538:HYDTH RS00380
gene id: 608538:HYDTH_RS00380
uniprot id: D3DFD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

608538:HYDTH RS01080
gene id: 608538:HYDTH_RS01080
uniprot id: D3DFT0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

608538:HYDTH RS03375
gene id: 608538:HYDTH_RS03375
uniprot id: D3DH31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

608538:HYDTH RS06760
gene id: 608538:HYDTH_RS06760
uniprot id: D3DIZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

608538:HYDTH RS07975
gene id: 608538:HYDTH_RS07975
uniprot id: D3DJN1
names: Similarity
messages: Belongs to the glutamine synthetase family.

608538:HYDTH RS01585
gene id: 608538:HYDTH_RS01585
uniprot id: D3DG28
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

608538:HYDTH RS03900
gene id: 608538:HYDTH_RS03900
uniprot id: D3DHD5
names: Similarity
messages: Belongs to the UPF0235 family.

608538:HYDTH RS03870
gene id: 608538:HYDTH_RS03870
uniprot id: D3DHC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

608538:HYDTH RS03355
gene id: 608538:HYDTH_RS03355
uniprot id: D3DH27
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

608538:HYDTH RS09250
gene id: 608538:HYDTH_RS09250
uniprot id: D3DKD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

608538:HYDTH RS06880
gene id: 608538:HYDTH_RS06880
uniprot id: D3DJ13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

608538:HYDTH RS03780
gene id: 608538:HYDTH_RS03780
uniprot id: D3DHB1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

608538:HYDTH RS07045
gene id: 608538:HYDTH_RS07045
uniprot id: D3DJ46
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

608538:HYDTH RS09035
gene id: 608538:HYDTH_RS09035
uniprot id: D3DK92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

608538:HYDTH RS02105
gene id: 608538:HYDTH_RS02105
uniprot id: D3DGC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

608538:HYDTH RS01070
gene id: 608538:HYDTH_RS01070
uniprot id: D3DFS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

608538:HYDTH RS06130
gene id: 608538:HYDTH_RS06130
uniprot id: D3DIL8
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS06645
gene id: 608538:HYDTH_RS06645
uniprot id: D3DIW7
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

608538:HYDTH RS08210
gene id: 608538:HYDTH_RS08210
uniprot id: D3DJS7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

608538:HYDTH RS05145
gene id: 608538:HYDTH_RS05145
uniprot id: D3DI27
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS02850
gene id: 608538:HYDTH_RS02850
uniprot id: D3DGS8
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

608538:HYDTH RS05465
gene id: 608538:HYDTH_RS05465
uniprot id: D3DI93
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

608538:HYDTH RS07420
gene id: 608538:HYDTH_RS07420
uniprot id: D3DJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

608538:HYDTH RS02065
gene id: 608538:HYDTH_RS02065
uniprot id: D3DGC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS07020
gene id: 608538:HYDTH_RS07020
uniprot id: D3DJ41
names: PTM
names: Subunit
messages: Biotinylated.
messages: Heterohexadecamer of 8 large subunits and 8 small subunits.

608538:HYDTH RS04205
gene id: 608538:HYDTH_RS04205
uniprot id: D3DHJ5
names: Similarity
messages: Belongs to the CFA/CMAS family.

608538:HYDTH RS06125
gene id: 608538:HYDTH_RS06125
uniprot id: D3DIL7
names: Function
names: Similarity
messages: Belongs to the PqqB family.
messages: May be involved in the transport of PQQ or its precursor to the periplasm.

608538:HYDTH RS03570
gene id: 608538:HYDTH_RS03570
uniprot id: D3DH70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

608538:HYDTH RS04330
gene id: 608538:HYDTH_RS04330
uniprot id: D3DHM0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

608538:HYDTH RS07115
gene id: 608538:HYDTH_RS07115
uniprot id: D3DJ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS00345
gene id: 608538:HYDTH_RS00345
uniprot id: D3DFD2
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

608538:HYDTH RS06320
gene id: 608538:HYDTH_RS06320
uniprot id: D3DIQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS02260
gene id: 608538:HYDTH_RS02260
uniprot id: D3DGG0
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

608538:HYDTH RS07300
gene id: 608538:HYDTH_RS07300
uniprot id: D3DJ96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

608538:HYDTH RS03210
gene id: 608538:HYDTH_RS03210
uniprot id: D3DGZ9
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

608538:HYDTH RS06065
gene id: 608538:HYDTH_RS06065
uniprot id: D3DIK5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

608538:HYDTH RS01085
gene id: 608538:HYDTH_RS01085
uniprot id: D3DFT1
names: Similarity
messages: Belongs to the UPF0751 family.

608538:HYDTH RS05200
gene id: 608538:HYDTH_RS05200
uniprot id: D3DI41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS07150
gene id: 608538:HYDTH_RS07150
uniprot id: D3DJ67
names: Similarity
messages: Belongs to the threonine synthase family.

608538:HYDTH RS04910
gene id: 608538:HYDTH_RS04910
uniprot id: D3DHY4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

608538:HYDTH RS03700
gene id: 608538:HYDTH_RS03700
uniprot id: D3DH96
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

608538:HYDTH RS00325
gene id: 608538:HYDTH_RS00325
uniprot id: D3DFC8
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS01280
gene id: 608538:HYDTH_RS01280
uniprot id: D3DFW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

608538:HYDTH RS08375
gene id: 608538:HYDTH_RS08375
uniprot id: D3DJW0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

608538:HYDTH RS06305
gene id: 608538:HYDTH_RS06305
uniprot id: D3DIQ3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

608538:HYDTH RS00740
gene id: 608538:HYDTH_RS00740
uniprot id: D3DFL0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

608538:HYDTH RS00870
gene id: 608538:HYDTH_RS00870
uniprot id: D3DFN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

608538:HYDTH RS09255
gene id: 608538:HYDTH_RS09255
uniprot id: D3DKD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm

608538:HYDTH RS06840
gene id: 608538:HYDTH_RS06840
uniprot id: D3DJ05
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

608538:HYDTH RS06280
gene id: 608538:HYDTH_RS06280
uniprot id: D3DIP8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

608538:HYDTH RS05240
gene id: 608538:HYDTH_RS05240
uniprot id: D3DI49
names: Similarity
messages: Belongs to the GSP E family.

608538:HYDTH RS03595
gene id: 608538:HYDTH_RS03595
uniprot id: D3DH75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

608538:HYDTH RS01525
gene id: 608538:HYDTH_RS01525
uniprot id: D3DG16
names: Similarity
messages: Belongs to the class-I fumarase family.

608538:HYDTH RS09280
gene id: 608538:HYDTH_RS09280
uniprot id: D3DKE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00630
gene id: 608538:HYDTH_RS00630
uniprot id: D3DFI8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

608538:HYDTH RS02075
gene id: 608538:HYDTH_RS02075
uniprot id: D3DGC2
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS02485
gene id: 608538:HYDTH_RS02485
uniprot id: D3DGK5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

608538:HYDTH RS03460
gene id: 608538:HYDTH_RS03460
uniprot id: D3DH47
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS08025
gene id: 608538:HYDTH_RS08025
uniprot id: D3DJP0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS06010
gene id: 608538:HYDTH_RS06010
uniprot id: D3DIJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

608538:HYDTH RS03340
gene id: 608538:HYDTH_RS03340
uniprot id: D3DH24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS06475
gene id: 608538:HYDTH_RS06475
uniprot id: D3DIT3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

608538:HYDTH RS04240
gene id: 608538:HYDTH_RS04240
uniprot id: D3DHK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

608538:HYDTH RS03045
gene id: 608538:HYDTH_RS03045
uniprot id: D3DGW7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

608538:HYDTH RS01250
gene id: 608538:HYDTH_RS01250
uniprot id: D3DFW1
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

608538:HYDTH RS02410
gene id: 608538:HYDTH_RS02410
uniprot id: D3DGJ0
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

608538:HYDTH RS00910
gene id: 608538:HYDTH_RS00910
uniprot id: D3DFP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

608538:HYDTH RS03345
gene id: 608538:HYDTH_RS03345
uniprot id: D3DH25
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00060
gene id: 608538:HYDTH_RS00060
uniprot id: D3DF74
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

608538:HYDTH RS06435
gene id: 608538:HYDTH_RS06435
uniprot id: D3DIS6
names: Similarity
messages: Belongs to the universal stress protein A family.

608538:HYDTH RS05135
gene id: 608538:HYDTH_RS05135
uniprot id: D3DI24
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

608538:HYDTH RS04400
gene id: 608538:HYDTH_RS04400
uniprot id: D3DHN0
names: Function
names: Similarity
messages: Belongs to the OMP decarboxylase family.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

608538:HYDTH RS01885
gene id: 608538:HYDTH_RS01885
uniprot id: D3DG87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

608538:HYDTH RS03485
gene id: 608538:HYDTH_RS03485
uniprot id: D3DH52
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

608538:HYDTH RS00470
gene id: 608538:HYDTH_RS00470
uniprot id: D3DFF7
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

608538:HYDTH RS02120
gene id: 608538:HYDTH_RS02120
uniprot id: D3DGD1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

608538:HYDTH RS04300
gene id: 608538:HYDTH_RS04300
uniprot id: D3DHL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

608538:HYDTH RS07435
gene id: 608538:HYDTH_RS07435
uniprot id: D3DJC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS00215
gene id: 608538:HYDTH_RS00215
uniprot id: D3DFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

608538:HYDTH RS07110
gene id: 608538:HYDTH_RS07110
uniprot id: D3DJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

608538:HYDTH RS07070
gene id: 608538:HYDTH_RS07070
uniprot id: D3DJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS00100
gene id: 608538:HYDTH_RS00100
uniprot id: D3DF83
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

608538:HYDTH RS05665
gene id: 608538:HYDTH_RS05665
uniprot id: D3DID2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

608538:HYDTH RS09595
gene id: 608538:HYDTH_RS09595
uniprot id: D3DKK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

608538:HYDTH RS02570
gene id: 608538:HYDTH_RS02570
uniprot id: D3DGM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

608538:HYDTH RS06930
gene id: 608538:HYDTH_RS06930
uniprot id: D3DJ22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

608538:HYDTH RS05080
gene id: 608538:HYDTH_RS05080
uniprot id: D3DI15
names: Similarity
messages: Belongs to the HupH/HyaF family.

608538:HYDTH RS09515
gene id: 608538:HYDTH_RS09515
uniprot id: D3DKI9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS01170
gene id: 608538:HYDTH_RS01170
uniprot id: D3DFU9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

608538:HYDTH RS03055
gene id: 608538:HYDTH_RS03055
uniprot id: D3DGW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

608538:HYDTH RS09375
gene id: 608538:HYDTH_RS09375
uniprot id: D3DKG2
names: Similarity
messages: Belongs to the FUN14 family.

608538:HYDTH RS08510
gene id: 608538:HYDTH_RS08510
uniprot id: D3DJY9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

608538:HYDTH RS02210
gene id: 608538:HYDTH_RS02210
uniprot id: D3DGF0
names: Similarity
messages: Belongs to the UPF0102 family.

608538:HYDTH RS01025
gene id: 608538:HYDTH_RS01025
uniprot id: D3DFR9
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS02430
gene id: 608538:HYDTH_RS02430
uniprot id: D3DGJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS02175
gene id: 608538:HYDTH_RS02175
uniprot id: D3DGE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

608538:HYDTH RS08295
gene id: 608538:HYDTH_RS08295
uniprot id: D3DJU4
names: Similarity
messages: Belongs to the bacterial secretin family.

608538:HYDTH RS03305
gene id: 608538:HYDTH_RS03305
uniprot id: D3DH18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

608538:HYDTH RS05625
gene id: 608538:HYDTH_RS05625
uniprot id: D3DIC5
names: Similarity
messages: Belongs to the P(II) protein family.

608538:HYDTH RS07800
gene id: 608538:HYDTH_RS07800
uniprot id: D3DJJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

608538:HYDTH RS00875
gene id: 608538:HYDTH_RS00875
uniprot id: D3DFN8
names: Similarity
messages: Belongs to the RutC family.

608538:HYDTH RS07875
gene id: 608538:HYDTH_RS07875
uniprot id: D3DJL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

608538:HYDTH RS09240
gene id: 608538:HYDTH_RS09240
uniprot id: D3DKD4
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

608538:HYDTH RS07185
gene id: 608538:HYDTH_RS07185
uniprot id: D3DJ74
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

608538:HYDTH RS08720
gene id: 608538:HYDTH_RS08720
uniprot id: D3DK28
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

608538:HYDTH RS04285
gene id: 608538:HYDTH_RS04285
uniprot id: D3DHL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

608538:HYDTH RS01860
gene id: 608538:HYDTH_RS01860
uniprot id: D3DG82
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

608538:HYDTH RS03155
gene id: 608538:HYDTH_RS03155
uniprot id: D3DGY8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS08450
gene id: 608538:HYDTH_RS08450
uniprot id: D3DJX7
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

608538:HYDTH RS04920
gene id: 608538:HYDTH_RS04920
uniprot id: D3DHY6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

608538:HYDTH RS01095
gene id: 608538:HYDTH_RS01095
uniprot id: D3DFT3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS06600
gene id: 608538:HYDTH_RS06600
uniprot id: D3DIV8
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

608538:HYDTH RS08240
gene id: 608538:HYDTH_RS08240
uniprot id: D3DJT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

608538:HYDTH RS05905
gene id: 608538:HYDTH_RS05905
uniprot id: D3DIH4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

608538:HYDTH RS04800
gene id: 608538:HYDTH_RS04800
uniprot id: D3DHW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS09690
gene id: 608538:HYDTH_RS09690
uniprot id: D3DGZ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

608538:HYDTH RS00560
gene id: 608538:HYDTH_RS00560
uniprot id: D3DFH5
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

608538:HYDTH RS01820
gene id: 608538:HYDTH_RS01820
uniprot id: D3DG74
names: Similarity
messages: Belongs to the GARS family.

608538:HYDTH RS06580
gene id: 608538:HYDTH_RS06580
uniprot id: D3DIV4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

608538:HYDTH RS09190
gene id: 608538:HYDTH_RS09190
uniprot id: D3DKC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Cytoplasm
messages: Homodimer.
messages: Its primary function is to catalyze the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-threonine, L-allo-threonine, L-threo-beta-phenylserine and L-erythro-beta-phenylserine. This second activity is likely to be physiological in H.thermophilus, which is an organism that lacks the ortholog gene for the 'real' threonine aldolase characterized in mesophilic bacteria (LtaE), yeast and plants.

608538:HYDTH RS00450
gene id: 608538:HYDTH_RS00450
uniprot id: D3DFF3
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

608538:HYDTH RS03520
gene id: 608538:HYDTH_RS03520
uniprot id: D3DH59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

608538:HYDTH RS05445
gene id: 608538:HYDTH_RS05445
uniprot id: D3DI89
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

608538:HYDTH RS05945
gene id: 608538:HYDTH_RS05945
uniprot id: D3DIH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

608538:HYDTH RS02195
gene id: 608538:HYDTH_RS02195
uniprot id: D3DGE6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

608538:HYDTH RS04185
gene id: 608538:HYDTH_RS04185
uniprot id: D3DHJ1
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00890
gene id: 608538:HYDTH_RS00890
uniprot id: D3DFP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

608538:HYDTH RS00455
gene id: 608538:HYDTH_RS00455
uniprot id: D3DFF4
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS05540
gene id: 608538:HYDTH_RS05540
uniprot id: D3DIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell inner membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

608538:HYDTH RS09230
gene id: 608538:HYDTH_RS09230
uniprot id: D2Z0I0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

608538:HYDTH RS03525
gene id: 608538:HYDTH_RS03525
uniprot id: D3DH60
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

608538:HYDTH RS05570
gene id: 608538:HYDTH_RS05570
uniprot id: D3DIB4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

608538:HYDTH RS01160
gene id: 608538:HYDTH_RS01160
uniprot id: D3DFU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Periplasm

608538:HYDTH RS06240
gene id: 608538:HYDTH_RS06240
uniprot id: D3DIP0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

608538:HYDTH RS02580
gene id: 608538:HYDTH_RS02580
uniprot id: D3DGM4
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

608538:HYDTH RS01615
gene id: 608538:HYDTH_RS01615
uniprot id: D3DG33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

608538:HYDTH RS02880
gene id: 608538:HYDTH_RS02880
uniprot id: D3DGT4
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

608538:HYDTH RS04950
gene id: 608538:HYDTH_RS04950
uniprot id: D3DHY9
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

608538:HYDTH RS07525
gene id: 608538:HYDTH_RS07525
uniprot id: D3DJE3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

608538:HYDTH RS03635
gene id: 608538:HYDTH_RS03635
uniprot id: D3DH83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

608538:HYDTH RS08505
gene id: 608538:HYDTH_RS08505
uniprot id: D3DJY8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

608538:HYDTH RS01535
gene id: 608538:HYDTH_RS01535
uniprot id: D3DG18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

608538:HYDTH RS01815
gene id: 608538:HYDTH_RS01815
uniprot id: D3DG73
names: Similarity
messages: Belongs to the histone deacetylase family.

608538:HYDTH RS06865
gene id: 608538:HYDTH_RS06865
uniprot id: D3DJ10
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

608538:HYDTH RS02890
gene id: 608538:HYDTH_RS02890
uniprot id: D3DGT6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

608538:HYDTH RS03590
gene id: 608538:HYDTH_RS03590
uniprot id: D3DH74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

608538:HYDTH RS07715
gene id: 608538:HYDTH_RS07715
uniprot id: D3DJI0
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

608538:HYDTH RS00045
gene id: 608538:HYDTH_RS00045
uniprot id: D3DF71
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS09245
gene id: 608538:HYDTH_RS09245
uniprot id: D3DKD5
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

608538:HYDTH RS06515
gene id: 608538:HYDTH_RS06515
uniprot id: D3DIU1
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

608538:HYDTH RS03385
gene id: 608538:HYDTH_RS03385
uniprot id: D3DH33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

608538:HYDTH RS02530
gene id: 608538:HYDTH_RS02530
uniprot id: D3DGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

608538:HYDTH RS06430
gene id: 608538:HYDTH_RS06430
uniprot id: D3DIS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

608538:HYDTH RS07160
gene id: 608538:HYDTH_RS07160
uniprot id: D3DJ69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

608538:HYDTH RS08425
gene id: 608538:HYDTH_RS08425
uniprot id: D3DJX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

608538:HYDTH RS06120
gene id: 608538:HYDTH_RS06120
uniprot id: D3DIL6
names: Function
names: Similarity
messages: Belongs to the PqqC family.
messages: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.

608538:HYDTH RS07750
gene id: 608538:HYDTH_RS07750
uniprot id: D3DJI7
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

608538:HYDTH RS05065
gene id: 608538:HYDTH_RS05065
uniprot id: D3DI12
names: Similarity
messages: Belongs to the HypE family.

608538:HYDTH RS08575
gene id: 608538:HYDTH_RS08575
uniprot id: D3DK02
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

608538:HYDTH RS07490
gene id: 608538:HYDTH_RS07490
uniprot id: D3DJD6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS03140
gene id: 608538:HYDTH_RS03140
uniprot id: D3DGY6
names: Similarity
messages: Belongs to the UPF0758 family.

608538:HYDTH RS01895
gene id: 608538:HYDTH_RS01895
uniprot id: D3DG89
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

608538:HYDTH RS06895
gene id: 608538:HYDTH_RS06895
uniprot id: D3DJ16
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

608538:HYDTH RS05960
gene id: 608538:HYDTH_RS05960
uniprot id: D3DII2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

608538:HYDTH RS06940
gene id: 608538:HYDTH_RS06940
uniprot id: D3DJ24
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

608538:HYDTH RS07460
gene id: 608538:HYDTH_RS07460
uniprot id: D3DJC9
names: Similarity
messages: Belongs to the hemerythrin family.

608538:HYDTH RS05670
gene id: 608538:HYDTH_RS05670
uniprot id: D3DID3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

608538:HYDTH RS06860
gene id: 608538:HYDTH_RS06860
uniprot id: D3DJ09
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

608538:HYDTH RS03885
gene id: 608538:HYDTH_RS03885
uniprot id: D3DHD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS08385
gene id: 608538:HYDTH_RS08385
uniprot id: D3DJW3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

608538:HYDTH RS02535
gene id: 608538:HYDTH_RS02535
uniprot id: D3DGL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

608538:HYDTH RS08265
gene id: 608538:HYDTH_RS08265
uniprot id: D3DJT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

608538:HYDTH RS06030
gene id: 608538:HYDTH_RS06030
uniprot id: D3DIJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

608538:HYDTH RS00590
gene id: 608538:HYDTH_RS00590
uniprot id: D3DFI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

608538:HYDTH RS03510
gene id: 608538:HYDTH_RS03510
uniprot id: D3DH57
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

608538:HYDTH RS04135
gene id: 608538:HYDTH_RS04135
uniprot id: D3DHI1
names: Similarity
messages: Belongs to the CarB family.

608538:HYDTH RS04755
gene id: 608538:HYDTH_RS04755
uniprot id: D3DHV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS09095
gene id: 608538:HYDTH_RS09095
uniprot id: D3DKA5
names: Similarity
messages: Belongs to the HupF/HypC family.

608538:HYDTH RS07190
gene id: 608538:HYDTH_RS07190
uniprot id: D3DJ75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

608538:HYDTH RS07175
gene id: 608538:HYDTH_RS07175
uniprot id: D3DJ72
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

608538:HYDTH RS06045
gene id: 608538:HYDTH_RS06045
uniprot id: D3DIK1
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.

608538:HYDTH RS05280
gene id: 608538:HYDTH_RS05280
uniprot id: D3DI57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

608538:HYDTH RS00010
gene id: 608538:HYDTH_RS00010
uniprot id: D3DF66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

608538:HYDTH RS06655
gene id: 608538:HYDTH_RS06655
uniprot id: D3DIW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

608538:HYDTH RS09530
gene id: 608538:HYDTH_RS09530
uniprot id: D3DKJ2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

608538:HYDTH RS05110
gene id: 608538:HYDTH_RS05110
uniprot id: D3DI21
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

608538:HYDTH RS02255
gene id: 608538:HYDTH_RS02255
uniprot id: D3DGF9
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

608538:HYDTH RS00115
gene id: 608538:HYDTH_RS00115
uniprot id: D3DF86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

608538:HYDTH RS08540
gene id: 608538:HYDTH_RS08540
uniprot id: D3DJZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

608538:HYDTH RS05255
gene id: 608538:HYDTH_RS05255
uniprot id: D3DI52
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

608538:HYDTH RS00320
gene id: 608538:HYDTH_RS00320
uniprot id: D3DFC7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

608538:HYDTH RS07530
gene id: 608538:HYDTH_RS07530
uniprot id: D3DJE4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

608538:HYDTH RS06525
gene id: 608538:HYDTH_RS06525
uniprot id: D3DIU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

608538:HYDTH RS07990
gene id: 608538:HYDTH_RS07990
uniprot id: D3DJN4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

608538:HYDTH RS08415
gene id: 608538:HYDTH_RS08415
uniprot id: D3DJX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

608538:HYDTH RS06310
gene id: 608538:HYDTH_RS06310
uniprot id: D3DIQ4
names: Similarity
messages: Belongs to the CarB family.

608538:HYDTH RS03200
gene id: 608538:HYDTH_RS03200
uniprot id: D3DGZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

608538:HYDTH RS01540
gene id: 608538:HYDTH_RS01540
uniprot id: D3DG19
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

608538:HYDTH RS06560
gene id: 608538:HYDTH_RS06560
uniprot id: D3DIV0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

608538:HYDTH RS02665
gene id: 608538:HYDTH_RS02665
uniprot id: D3DGP2
names: Similarity
messages: Belongs to the RuvC family.

608538:HYDTH RS01145
gene id: 608538:HYDTH_RS01145
uniprot id: D3DFU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

608538:HYDTH RS00430
gene id: 608538:HYDTH_RS00430
uniprot id: D3DFE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00770
gene id: 608538:HYDTH_RS00770
uniprot id: D3DFL6
names: Similarity
messages: Belongs to the SCO1/2 family.

608538:HYDTH RS09355
gene id: 608538:HYDTH_RS09355
uniprot id: D3DKF8
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

608538:HYDTH RS08090
gene id: 608538:HYDTH_RS08090
uniprot id: D3DJQ3
names: Similarity
messages: Belongs to the peptidase U62 family.

608538:HYDTH RS02125
gene id: 608538:HYDTH_RS02125
uniprot id: D3DGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

608538:HYDTH RS06020
gene id: 608538:HYDTH_RS06020
uniprot id: D3DIJ6
names: Similarity
messages: Belongs to the SCO1/2 family.

608538:HYDTH RS04785
gene id: 608538:HYDTH_RS04785
uniprot id: D3DHW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

608538:HYDTH RS02390
gene id: 608538:HYDTH_RS02390
uniprot id: D3DGI6
names: Similarity
messages: Belongs to the fabD family.

608538:HYDTH RS04305
gene id: 608538:HYDTH_RS04305
uniprot id: D3DHL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

608538:HYDTH RS03945
gene id: 608538:HYDTH_RS03945
uniprot id: D3DHE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell inner membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

608538:HYDTH RS03865
gene id: 608538:HYDTH_RS03865
uniprot id: D3DHC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

608538:HYDTH RS00495
gene id: 608538:HYDTH_RS00495
uniprot id: D3DFG2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS07890
gene id: 608538:HYDTH_RS07890
uniprot id: D3DJL5
names: Similarity
messages: Belongs to the UPF0047 family.

608538:HYDTH RS05245
gene id: 608538:HYDTH_RS05245
uniprot id: D3DI50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

608538:HYDTH RS05845
gene id: 608538:HYDTH_RS05845
uniprot id: D3DIG3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

608538:HYDTH RS09120
gene id: 608538:HYDTH_RS09120
uniprot id: D3DKB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

608538:HYDTH RS08690
gene id: 608538:HYDTH_RS08690
uniprot id: D3DK23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

608538:HYDTH RS01705
gene id: 608538:HYDTH_RS01705
uniprot id: D3DG52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

608538:HYDTH RS05565
gene id: 608538:HYDTH_RS05565
uniprot id: D3DIB3
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

608538:HYDTH RS08585
gene id: 608538:HYDTH_RS08585
uniprot id: D3DK04
names: Similarity
messages: Belongs to the PstS family.

608538:HYDTH RS00710
gene id: 608538:HYDTH_RS00710
uniprot id: D3DFK4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00515
gene id: 608538:HYDTH_RS00515
uniprot id: D3DFG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

608538:HYDTH RS07380
gene id: 608538:HYDTH_RS07380
uniprot id: D3DJB4
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

608538:HYDTH RS00420
gene id: 608538:HYDTH_RS00420
uniprot id: D3DFE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

608538:HYDTH RS08915
gene id: 608538:HYDTH_RS08915
uniprot id: D3DK68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS01255
gene id: 608538:HYDTH_RS01255
uniprot id: D3DFW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

608538:HYDTH RS07870
gene id: 608538:HYDTH_RS07870
uniprot id: D3DJL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

608538:HYDTH RS06830
gene id: 608538:HYDTH_RS06830
uniprot id: D3DJ03
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

608538:HYDTH RS09000
gene id: 608538:HYDTH_RS09000
uniprot id: D3DK85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

608538:HYDTH RS08610
gene id: 608538:HYDTH_RS08610
uniprot id: D3DK08
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

608538:HYDTH RS04845
gene id: 608538:HYDTH_RS04845
uniprot id: D3DHX2
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

608538:HYDTH RS07885
gene id: 608538:HYDTH_RS07885
uniprot id: D3DJL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

608538:HYDTH RS01110
gene id: 608538:HYDTH_RS01110
uniprot id: D3DFT6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

608538:HYDTH RS02235
gene id: 608538:HYDTH_RS02235
uniprot id: D3DGF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

608538:HYDTH RS08190
gene id: 608538:HYDTH_RS08190
uniprot id: D3DJS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

608538:HYDTH RS03245
gene id: 608538:HYDTH_RS03245
uniprot id: D3DH06
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

608538:HYDTH RS00545
gene id: 608538:HYDTH_RS00545
uniprot id: D3DFH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS02145
gene id: 608538:HYDTH_RS02145
uniprot id: D3DGD6
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

608538:HYDTH RS01520
gene id: 608538:HYDTH_RS01520
uniprot id: D3DG15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

608538:HYDTH RS07025
gene id: 608538:HYDTH_RS07025
uniprot id: D3DJ42
names: Subunit
messages: Heterohexadecamer of 8 large subunits and 8 small subunits.

608538:HYDTH RS08565
gene id: 608538:HYDTH_RS08565
uniprot id: D3DK00
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

608538:HYDTH RS00335
gene id: 608538:HYDTH_RS00335
uniprot id: D3DFD0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608538:HYDTH RS00945
gene id: 608538:HYDTH_RS00945
uniprot id: D3DFQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

608538:HYDTH RS07785
gene id: 608538:HYDTH_RS07785
uniprot id: D3DJJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

608538:HYDTH RS04015
gene id: 608538:HYDTH_RS04015
uniprot id: D3DHF9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

608538:HYDTH RS00510
gene id: 608538:HYDTH_RS00510
uniprot id: D3DFG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

608538:HYDTH RS04295
gene id: 608538:HYDTH_RS04295
uniprot id: D3DHL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

608538:HYDTH RS05900
gene id: 608538:HYDTH_RS05900
uniprot id: D3DIH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

608538:HYDTH RS02180
gene id: 608538:HYDTH_RS02180
uniprot id: D3DGE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

608538:HYDTH RS00670
gene id: 608538:HYDTH_RS00670
uniprot id: D3DFJ6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

608538:HYDTH RS04670
gene id: 608538:HYDTH_RS04670
uniprot id: D3DHT9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

608538:HYDTH RS09315
gene id: 608538:HYDTH_RS09315
uniprot id: D3DKE9
names: Subcellular Location Annotation
messages: Periplasm

608538:HYDTH RS04055
gene id: 608538:HYDTH_RS04055
uniprot id: D3DHG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

608538:HYDTH RS08500
gene id: 608538:HYDTH_RS08500
uniprot id: D3DJY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

608538:HYDTH RS03955
gene id: 608538:HYDTH_RS03955
uniprot id: D3DHE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

608538:HYDTH RS07535
gene id: 608538:HYDTH_RS07535
uniprot id: D3DJE5
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

608538:HYDTH RS09395
gene id: 608538:HYDTH_RS09395
uniprot id: D3DKG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

608538:HYDTH RS09410
gene id: 608538:HYDTH_RS09410
uniprot id: D3DKG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

608538:HYDTH RS03105
gene id: 608538:HYDTH_RS03105
uniprot id: D3DGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

608538:HYDTH RS05070
gene id: 608538:HYDTH_RS05070
uniprot id: D3DI13
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

608538:HYDTH RS00920
gene id: 608538:HYDTH_RS00920
uniprot id: D3DFP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

608538:HYDTH RS02955
gene id: 608538:HYDTH_RS02955
uniprot id: D3DGU9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS00415
gene id: 608538:HYDTH_RS00415
uniprot id: D3DFE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

608538:HYDTH RS05840
gene id: 608538:HYDTH_RS05840
uniprot id: D3DIG2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

608538:HYDTH RS05045
gene id: 608538:HYDTH_RS05045
uniprot id: D3DI08
names: Similarity
messages: Belongs to the UPF0166 family.

608538:HYDTH RS02110
gene id: 608538:HYDTH_RS02110
uniprot id: D3DGC9
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

608538:HYDTH RS04280
gene id: 608538:HYDTH_RS04280
uniprot id: D3DHL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

608538:HYDTH RS04990
gene id: 608538:HYDTH_RS04990
uniprot id: D3DHZ7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

608538:HYDTH RS00865
gene id: 608538:HYDTH_RS00865
uniprot id: D3DFN6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

608538:HYDTH RS02520
gene id: 608538:HYDTH_RS02520
uniprot id: D3DGL2
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

608538:HYDTH RS07495
gene id: 608538:HYDTH_RS07495
uniprot id: D3DJD7
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

608538:HYDTH RS01320
gene id: 608538:HYDTH_RS01320
uniprot id: D3DFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS02115
gene id: 608538:HYDTH_RS02115
uniprot id: D3DGD0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

608538:HYDTH RS05075
gene id: 608538:HYDTH_RS05075
uniprot id: D3DI14
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

608538:HYDTH RS01785
gene id: 608538:HYDTH_RS01785
uniprot id: D3DG67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

608538:HYDTH RS06270
gene id: 608538:HYDTH_RS06270
uniprot id: D3DIP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

608538:HYDTH RS01635
gene id: 608538:HYDTH_RS01635
uniprot id: D3DG37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

608538:HYDTH RS06665
gene id: 608538:HYDTH_RS06665
uniprot id: D3DIX1
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

608538:HYDTH RS01120
gene id: 608538:HYDTH_RS01120
uniprot id: D3DFT8
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

608538:HYDTH RS05040
gene id: 608538:HYDTH_RS05040
uniprot id: D3DI07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

608538:HYDTH RS07170
gene id: 608538:HYDTH_RS07170
uniprot id: D3DJ71
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS05650
gene id: 608538:HYDTH_RS05650
uniprot id: D3DIC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifW family.
messages: Homotrimer; associates with NifD.
messages: May protect the nitrogenase Fe-Mo protein from oxidative damage.

608538:HYDTH RS01675
gene id: 608538:HYDTH_RS01675
uniprot id: D3DG46
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

608538:HYDTH RS03625
gene id: 608538:HYDTH_RS03625
uniprot id: D3DH81
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

608538:HYDTH RS03120
gene id: 608538:HYDTH_RS03120
uniprot id: D3DGY2
names: Similarity
messages: Belongs to the transglycosylase Slt family.

608538:HYDTH RS03845
gene id: 608538:HYDTH_RS03845
uniprot id: D3DHC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

608538:HYDTH RS06410
gene id: 608538:HYDTH_RS06410
uniprot id: D3DIS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

608538:HYDTH RS09045
gene id: 608538:HYDTH_RS09045
uniprot id: D3DK94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

608538:HYDTH RS08065
gene id: 608538:HYDTH_RS08065
uniprot id: D3DJP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

608538:HYDTH RS00195
gene id: 608538:HYDTH_RS00195
uniprot id: D3DFA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

608538:HYDTH RS00370
gene id: 608538:HYDTH_RS00370
uniprot id: D3DFD7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Membrane

608538:HYDTH RS04930
gene id: 608538:HYDTH_RS04930
uniprot id: D3DHY8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

608538:HYDTH RS02885
gene id: 608538:HYDTH_RS02885
uniprot id: D3DGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

608538:HYDTH RS01790
gene id: 608538:HYDTH_RS01790
uniprot id: D3DG68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

608538:HYDTH RS05560
gene id: 608538:HYDTH_RS05560
uniprot id: D3DIB2
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

608538:HYDTH RS01180
gene id: 608538:HYDTH_RS01180
uniprot id: D3DFV1
names: Similarity
messages: Belongs to the peptidase S49 family.

608538:HYDTH RS00220
gene id: 608538:HYDTH_RS00220
uniprot id: D3DFA7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

608538:HYDTH RS03530
gene id: 608538:HYDTH_RS03530
uniprot id: D3DH61
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

608538:HYDTH RS04265
gene id: 608538:HYDTH_RS04265
uniprot id: D3DHK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

608538:HYDTH RS09005
gene id: 608538:HYDTH_RS09005
uniprot id: D3DK86
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

608538:HYDTH RS05870
gene id: 608538:HYDTH_RS05870
uniprot id: D3DIG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

608538:HYDTH RS01045
gene id: 608538:HYDTH_RS01045
uniprot id: D3DFS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane
messages: Membrane

608538:HYDTH RS08970
gene id: 608538:HYDTH_RS08970
uniprot id: D3DK79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS06025
gene id: 608538:HYDTH_RS06025
uniprot id: D3DIJ7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

608538:HYDTH RS00895
gene id: 608538:HYDTH_RS00895
uniprot id: D3DFP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

608538:HYDTH RS03005
gene id: 608538:HYDTH_RS03005
uniprot id: D3DGV9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS01980
gene id: 608538:HYDTH_RS01980
uniprot id: D3DGA5
names: Similarity
messages: Belongs to the bacterial PQQ dehydrogenase family.

608538:HYDTH RS08995
gene id: 608538:HYDTH_RS08995
uniprot id: D3DK84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS02435
gene id: 608538:HYDTH_RS02435
uniprot id: D3DGJ5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

608538:HYDTH RS08990
gene id: 608538:HYDTH_RS08990
uniprot id: D3DK83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS06390
gene id: 608538:HYDTH_RS06390
uniprot id: D3DIR7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

608538:HYDTH RS05155
gene id: 608538:HYDTH_RS05155
uniprot id: D3DI29
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS09565
gene id: 608538:HYDTH_RS09565
uniprot id: D3DKJ9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

608538:HYDTH RS05890
gene id: 608538:HYDTH_RS05890
uniprot id: D3DIH1
names: Similarity
messages: Belongs to the DprA/Smf family.

608538:HYDTH RS01670
gene id: 608538:HYDTH_RS01670
uniprot id: D3DG45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS03630
gene id: 608538:HYDTH_RS03630
uniprot id: D3DH82
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

608538:HYDTH RS04925
gene id: 608538:HYDTH_RS04925
uniprot id: D3DHY7
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

608538:HYDTH RS05125
gene id: 608538:HYDTH_RS05125
uniprot id: D3DI22
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

608538:HYDTH RS05800
gene id: 608538:HYDTH_RS05800
uniprot id: D3DIF5
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS09605
gene id: 608538:HYDTH_RS09605
uniprot id: D3DKK8
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

608538:HYDTH RS05550
gene id: 608538:HYDTH_RS05550
uniprot id: D3DIB0
names: Cofactor
names: PTM
names: Subcellular Location Annotation
messages: Binds 2 heme groups per subunit.
messages: Binds 2 heme groups.
messages: Periplasm

608538:HYDTH RS01610
gene id: 608538:HYDTH_RS01610
uniprot id: D3DG32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

608538:HYDTH RS03640
gene id: 608538:HYDTH_RS03640
uniprot id: D3DH84
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

608538:HYDTH RS08730
gene id: 608538:HYDTH_RS08730
uniprot id: D3DK30
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

608538:HYDTH RS08555
gene id: 608538:HYDTH_RS08555
uniprot id: D3DJZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

608538:HYDTH RS07605
gene id: 608538:HYDTH_RS07605
uniprot id: D3DJF9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

608538:HYDTH RS00900
gene id: 608538:HYDTH_RS00900
uniprot id: D3DFP3
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

608538:HYDTH RS05825
gene id: 608538:HYDTH_RS05825
uniprot id: D3DIF9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

608538:HYDTH RS02245
gene id: 608538:HYDTH_RS02245
uniprot id: D3DGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

608538:HYDTH RS06730
gene id: 608538:HYDTH_RS06730
uniprot id: D3DIY4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

608538:HYDTH RS05235
gene id: 608538:HYDTH_RS05235
uniprot id: D3DI48
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

608538:HYDTH RS03320
gene id: 608538:HYDTH_RS03320
uniprot id: D3DH21
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS00845
gene id: 608538:HYDTH_RS00845
uniprot id: D3DFN2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

608538:HYDTH RS04895
gene id: 608538:HYDTH_RS04895
uniprot id: D3DHY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

608538:HYDTH RS02545
gene id: 608538:HYDTH_RS02545
uniprot id: D3DGL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

608538:HYDTH RS09105
gene id: 608538:HYDTH_RS09105
uniprot id: D3DKA7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

608538:HYDTH RS04810
gene id: 608538:HYDTH_RS04810
uniprot id: D3DHW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

608538:HYDTH RS00800
gene id: 608538:HYDTH_RS00800
uniprot id: D3DFM3
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04215
gene id: 608538:HYDTH_RS04215
uniprot id: D3DHJ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

608538:HYDTH RS08145
gene id: 608538:HYDTH_RS08145
uniprot id: D3DJR4
names: Similarity
messages: Belongs to the peptidase M16 family.

608538:HYDTH RS07125
gene id: 608538:HYDTH_RS07125
uniprot id: D3DJ62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

608538:HYDTH RS05380
gene id: 608538:HYDTH_RS05380
uniprot id: D3DI75
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

608538:HYDTH RS02290
gene id: 608538:HYDTH_RS02290
uniprot id: D3DGG6
names: Similarity
messages: Belongs to the peptidase A31 family.

608538:HYDTH RS04065
gene id: 608538:HYDTH_RS04065
uniprot id: D3DHG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

608538:HYDTH RS01335
gene id: 608538:HYDTH_RS01335
uniprot id: D3DFX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

608538:HYDTH RS04740
gene id: 608538:HYDTH_RS04740
uniprot id: D3DHV3
names: Similarity
messages: Belongs to the SCO1/2 family.

608538:HYDTH RS04970
gene id: 608538:HYDTH_RS04970
uniprot id: D3DHZ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

608538:HYDTH RS03260
gene id: 608538:HYDTH_RS03260
uniprot id: D3DH09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

608538:HYDTH RS06625
gene id: 608538:HYDTH_RS06625
uniprot id: D3DIW3
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS04735
gene id: 608538:HYDTH_RS04735
uniprot id: D3DHV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

608538:HYDTH RS09300
gene id: 608538:HYDTH_RS09300
uniprot id: D3DKE6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

608538:HYDTH RS03835
gene id: 608538:HYDTH_RS03835
uniprot id: D3DHC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

608538:HYDTH RS00180
gene id: 608538:HYDTH_RS00180
uniprot id: D3DF99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

608538:HYDTH RS06615
gene id: 608538:HYDTH_RS06615
uniprot id: D3DIW1
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

608538:HYDTH RS05060
gene id: 608538:HYDTH_RS05060
uniprot id: D3DI11
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

608538:HYDTH RS05205
gene id: 608538:HYDTH_RS05205
uniprot id: D3DI42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

608538:HYDTH RS01075
gene id: 608538:HYDTH_RS01075
uniprot id: D3DFS9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

608538:HYDTH RS09125
gene id: 608538:HYDTH_RS09125
uniprot id: D3DKB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

608538:HYDTH RS08645
gene id: 608538:HYDTH_RS08645
uniprot id: D3DK14
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS09015
gene id: 608538:HYDTH_RS09015
uniprot id: D3DK88
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

608538:HYDTH RS03855
gene id: 608538:HYDTH_RS03855
uniprot id: D3DHC6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

608538:HYDTH RS00925
gene id: 608538:HYDTH_RS00925
uniprot id: D3DFP8
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity is not inhibited by EDTA in vitro, nor enhanced by the addition of Mg(2+).
messages: Belongs to the histidine phosphatase superfamily. Metal-independent phosphoserine phosphatase family.
messages: Heterodimer with PspA. The PspB subunit appears to have no or considerably lower PSP activity compared with that of PspA.
messages: Part of a complex that catalyzes the dephosphorylation of L-phosphoserine to serine and inorganic phosphate. Is poorly or not active toward D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, para-nitrophenylphosphate, and fructose-6-phosphate. Does not display phosphoglycerate mutase activity.

608538:HYDTH RS08470
gene id: 608538:HYDTH_RS08470
uniprot id: D3DJY1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

608538:HYDTH RS08170
gene id: 608538:HYDTH_RS08170
uniprot id: D3DJR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

608538:HYDTH RS01805
gene id: 608538:HYDTH_RS01805
uniprot id: D3DG71
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

608538:HYDTH RS03950
gene id: 608538:HYDTH_RS03950
uniprot id: D3DHE6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

608538:HYDTH RS07075
gene id: 608538:HYDTH_RS07075
uniprot id: D3DJ52
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

608538:HYDTH RS08910
gene id: 608538:HYDTH_RS08910
uniprot id: D3DK67
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

608538:HYDTH RS00145
gene id: 608538:HYDTH_RS00145
uniprot id: D3DF92
names: Subcellular Location Annotation
messages: Membrane

608538:HYDTH RS02505
gene id: 608538:HYDTH_RS02505
uniprot id: D3DGK9
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

608538:HYDTH RS07690
gene id: 608538:HYDTH_RS07690
uniprot id: D3DJH5
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.