59729:SRSF2
gene id: 59729:SRSF2
uniprot id: A0A674GKN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Nucleus

59729:LOC100189957
gene id: 59729:LOC100189957
uniprot id: B5FX73
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

59729:DIABLO
gene id: 59729:DIABLO
uniprot id: B5FY41
names: Subcellular Location Annotation
messages: Mitochondrion

59729:PYROXD1
gene id: 59729:PYROXD1
uniprot id: A0A674GDI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

59729:ANXA1
gene id: 59729:ANXA1
uniprot id: A0A674GDT8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium

59729:KHDRBS3
gene id: 59729:KHDRBS3
uniprot id: H0ZQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KHDRBS family.
messages: Cytoplasm

59729:PPFIA1
gene id: 59729:PPFIA1
uniprot id: A0A674GXR5
uniprot id: A0A674HTK9
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

59729:EIF1
gene id: 59729:EIF1
uniprot id: B5G1X8
names: Similarity
messages: Belongs to the SUI1 family.

59729:AP1S3
gene id: 59729:AP1S3
uniprot id: H0ZC35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

59729:FAM172A
gene id: 59729:FAM172A
uniprot id: A0A674HLC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM172 family.
messages: Cytoplasm
messages: Nucleus

59729:ARL5A
gene id: 59729:ARL5A
uniprot id: A0A674HNE5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

59729:MTMR12
gene id: 59729:MTMR12
uniprot id: A0A674GG04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Sarcoplasmic reticulum
messages: sarcomere

59729:GALNT4
gene id: 59729:GALNT4
uniprot id: A0A674GAP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

59729:BARX2
gene id: 59729:BARX2
uniprot id: H0YQM6
names: Subcellular Location Annotation
messages: Nucleus

59729:TMSB4X
gene id: 59729:TMSB4X
uniprot id: B5G0T6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

59729:PKIG
gene id: 59729:PKIG
uniprot id: B5FY16
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

59729:RPL13A
gene id: 59729:RPL13A
uniprot id: B5G289
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

59729:RPS3A
gene id: 59729:RPS3A
uniprot id: B5FZS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).
messages: Cytoplasm

59729:KATNB1
gene id: 59729:KATNB1
uniprot id: H0Z3A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat KATNB1 family.
messages: Cytoplasm
messages: Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.
messages: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

59729:RPS6KA2
gene id: 59729:RPS6KA2
uniprot id: A0A674GI56
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

59729:PDE6G
gene id: 59729:PDE6G
uniprot id: A0A674GI71
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

59729:RPS7
gene id: 59729:RPS7
uniprot id: B5FXQ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

59729:ATAD1
gene id: 59729:ATAD1
uniprot id: A0A674HLB2
names: Similarity
messages: Belongs to the AAA ATPase family.

59729:RUNX3
gene id: 59729:RUNX3
uniprot id: H0YSA1
names: Subcellular Location Annotation
messages: Nucleus

59729:ATP5PB
gene id: 59729:ATP5PB
uniprot id: B5FZ05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

59729:RMI1
gene id: 59729:RMI1
uniprot id: H0YY49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

59729:GLIS3
gene id: 59729:GLIS3
uniprot id: H0Z4D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

59729:SEC24A
gene id: 59729:SEC24A
uniprot id: A0A674GBL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

59729:FAM72A
gene id: 59729:FAM72A
uniprot id: A0A674HG84
names: Similarity
messages: Belongs to the FAM72 family.

59729:UBE2B
gene id: 59729:UBE2B
uniprot id: B5FZH8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:SCRN1
gene id: 59729:SCRN1
uniprot id: A0A674GR34
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

59729:RAX2
gene id: 59729:RAX2
uniprot id: H0YPE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

59729:VPS26A
gene id: 59729:VPS26A
uniprot id: B5FYY8
names: Similarity
messages: Belongs to the VPS26 family.

59729:RPS27A
gene id: 59729:RPS27A
uniprot id: H0Z9N6
names: Similarity
names: Subunit
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Ribosomal protein S27a is part of the 40S ribosomal subunit.

59729:MSTN
gene id: 59729:MSTN
uniprot id: H0ZKS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

59729:HTATSF1
gene id: 59729:HTATSF1
uniprot id: A0A674GGT0
names: Similarity
messages: Belongs to the HTATSF1 family.

59729:PRDM10
gene id: 59729:PRDM10
uniprot id: H0YQJ9
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

59729:C7H2orf76
gene id: 59729:C7H2orf76
uniprot id: A0A674HR33
names: Similarity
messages: Belongs to the UPF0538 family.

59729:CYCS
gene id: 59729:CYCS
uniprot id: B5FZX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

59729:ISOC1
gene id: 59729:ISOC1
uniprot id: H0YQ18
names: Similarity
messages: Belongs to the isochorismatase family.

59729:CX3CR1
gene id: 59729:CX3CR1
uniprot id: H1A5U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

59729:PPIA
gene id: 59729:PPIA
uniprot id: B5G3G3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:STAR
gene id: 59729:STAR
uniprot id: Q6RCE2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: May interact with TSPO.
messages: Mitochondrion
messages: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.

59729:INTS2
gene id: 59729:INTS2
uniprot id: H0ZBN0
names: Similarity
messages: Belongs to the Integrator subunit 2 family.

59729:RPL15
gene id: 59729:RPL15
uniprot id: B5KFM1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

59729:RPF2
gene id: 59729:RPF2
uniprot id: B5FY82
uniprot id: H0ZP68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

59729:IST1
gene id: 59729:IST1
uniprot id: H0ZD59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

59729:DIPK1B
gene id: 59729:DIPK1B
uniprot id: H0Z6J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Endoplasmic reticulum membrane

59729:LOC105759428
gene id: 59729:LOC105759428
uniprot id: H0ZKC7
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:GIMD1
gene id: 59729:GIMD1
uniprot id: H0Z0F0
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

59729:CLVS2
gene id: 59729:CLVS2
uniprot id: A0A674HGZ1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Endosome membrane
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network membrane

59729:RPSA
gene id: 59729:RPSA
uniprot id: B5FXT6
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Cell membrane
messages: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
messages: Cytoplasm
messages: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.
messages: Nucleus
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.
messages: This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.

59729:IRF2
gene id: 59729:IRF2
uniprot id: A0A674GA53
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

59729:MDH2
gene id: 59729:MDH2
uniprot id: B5G3E2
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

59729:TMEM200C
gene id: 59729:TMEM200C
uniprot id: A0A674HDU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

59729:PKD2L1
gene id: 59729:PKD2L1
uniprot id: A0A674H1E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

59729:EPC2
gene id: 59729:EPC2
uniprot id: H0ZNY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

59729:GPX8
gene id: 59729:GPX8
uniprot id: A0A674GNK1
names: Similarity
messages: Belongs to the glutathione peroxidase family.

59729:MDFIC
gene id: 59729:MDFIC
uniprot id: H0Z4G4
names: Similarity
messages: Belongs to the MDFI family.

59729:RSPO1
gene id: 59729:RSPO1
uniprot id: H0YTH5
names: Similarity
messages: Belongs to the R-spondin family.

59729:PPIB
gene id: 59729:PPIB
uniprot id: B5G4N8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:SH3RF1
gene id: 59729:SH3RF1
uniprot id: H0Z6T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

59729:DSTN
gene id: 59729:DSTN
uniprot id: B5G1W5
names: Function
names: Similarity
messages: Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
messages: Belongs to the actin-binding proteins ADF family.

59729:HBAA
gene id: 59729:HBAA
uniprot id: B5G3P7
names: Similarity
messages: Belongs to the globin family.

59729:PRKAA1
gene id: 59729:PRKAA1
uniprot id: A0A674HEW4
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

59729:RPL36
gene id: 59729:RPL36
uniprot id: B5FXV8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

59729:LOC100228347
gene id: 59729:LOC100228347
uniprot id: H0Z925
names: Subcellular Location Annotation
messages: cytoskeleton

59729:OLFM1
gene id: 59729:OLFM1
uniprot id: A0A674GQ86
uniprot id: A0A674GUN1
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

59729:FMR1
gene id: 59729:FMR1
uniprot id: B6CVD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cell membrane
messages: Cytoplasmic ribonucleoprotein granule
messages: Membrane
messages: Perikaryon
messages: Presynaptic cell membrane
messages: Synaptic cell membrane
messages: axon
messages: centromere
messages: dendrite
messages: dendritic spine
messages: filopodium tip
messages: growth cone
messages: neuron projection
messages: nucleolus
messages: perinuclear region
messages: synaptosome

59729:FOXP1
gene id: 59729:FOXP1
uniprot id: Q6QBA1
names: Subcellular Location Annotation
messages: Nucleus

59729:COPS8
gene id: 59729:COPS8
uniprot id: A0A674GLB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN8 family.
messages: Cytoplasm
messages: Nucleus

59729:S100B
gene id: 59729:S100B
uniprot id: B5FXV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

59729:GNG5
gene id: 59729:GNG5
uniprot id: A0A674GVY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

59729:LOC100220068
gene id: 59729:LOC100220068
uniprot id: H0ZA73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

59729:ISL1
gene id: 59729:ISL1
uniprot id: H0YVX4
names: Subcellular Location Annotation
messages: Nucleus

59729:TSPAN15
gene id: 59729:TSPAN15
uniprot id: H0Z0P9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:FBLN2
gene id: 59729:FBLN2
uniprot id: A0A674H1S6
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:RPL6
gene id: 59729:RPL6
uniprot id: A0A674GMD7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

59729:OSBPL5
gene id: 59729:OSBPL5
uniprot id: A0A674GLX7
names: Similarity
messages: Belongs to the OSBP family.

59729:LOC100227468
gene id: 59729:LOC100227468
uniprot id: A0A674HGC7
names: Similarity
messages: Belongs to the intermediate filament family.

59729:AFF2
gene id: 59729:AFF2
uniprot id: A0A674G973
names: Similarity
messages: Belongs to the AF4 family.

59729:MICOS13
gene id: 59729:MICOS13
uniprot id: H0YQG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

59729:RAD1
gene id: 59729:RAD1
uniprot id: H0YUP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

59729:EMC6
gene id: 59729:EMC6
uniprot id: H0Z950
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC6 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:WNT7A
gene id: 59729:WNT7A
uniprot id: H0YZX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

59729:LZIC
gene id: 59729:LZIC
uniprot id: A0A674GVQ5
names: Similarity
messages: Belongs to the CTNNBIP1 family.

59729:ANKH
gene id: 59729:ANKH
uniprot id: A0A674GXC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKH family.
messages: Membrane
messages: Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.

59729:RPL5
gene id: 59729:RPL5
uniprot id: B5G1T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

59729:MED31
gene id: 59729:MED31
uniprot id: B5G1M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:SLC17A6
gene id: 59729:SLC17A6
uniprot id: V9XYM9
names: Subcellular Location Annotation
messages: Membrane

59729:PPP4R3A
gene id: 59729:PPP4R3A
uniprot id: A0A674GCU8
names: Similarity
messages: Belongs to the SMEK family.

59729:PRKCE
gene id: 59729:PRKCE
uniprot id: A0A674HN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

59729:SMPX
gene id: 59729:SMPX
uniprot id: A0A674HVT1
names: Function
names: Similarity
messages: Belongs to the SMPX family.
messages: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.

59729:LDAF1
gene id: 59729:LDAF1
uniprot id: B5G2Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

59729:FUCA2
gene id: 59729:FUCA2
uniprot id: H0ZL71
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

59729:TMEM170A
gene id: 59729:TMEM170A
uniprot id: H0Z7U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

59729:ZDHHC21
gene id: 59729:ZDHHC21
uniprot id: A0A674GXM7
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

59729:LOC100223493
gene id: 59729:LOC100223493
uniprot id: H0ZG86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:CCN2
gene id: 59729:CCN2
uniprot id: H0ZN06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:SNRPD1
gene id: 59729:SNRPD1
uniprot id: B5FY37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

59729:CYFIP2
gene id: 59729:CYFIP2
uniprot id: H0YQV5
names: Similarity
messages: Belongs to the CYFIP family.

59729:HNRNPDL
gene id: 59729:HNRNPDL
uniprot id: B5G3X0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

59729:NXPH1
gene id: 59729:NXPH1
uniprot id: A0A674GFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

59729:EIF3I
gene id: 59729:EIF3I
uniprot id: B5FZ19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

59729:RHAG
gene id: 59729:RHAG
uniprot id: H0ZSQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

59729:CPN1
gene id: 59729:CPN1
uniprot id: H0ZFU2
names: Similarity
messages: Belongs to the peptidase M14 family.

59729:TMBIM4
gene id: 59729:TMBIM4
uniprot id: B5FXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

59729:SNCA
gene id: 59729:SNCA
uniprot id: Q4JHT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synuclein family.
messages: Membrane
messages: Nucleus
messages: Secreted
messages: Synapse

59729:NDUFV2
gene id: 59729:NDUFV2
uniprot id: B5G0Q5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

59729:LECT2
gene id: 59729:LECT2
uniprot id: H0YSK8
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

59729:UBE4A
gene id: 59729:UBE4A
uniprot id: H0YPA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

59729:CD44
gene id: 59729:CD44
uniprot id: A0A674H0E7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: microvillus

59729:TALDO1
gene id: 59729:TALDO1
uniprot id: H0ZBV9
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

59729:CTSD
gene id: 59729:CTSD
uniprot id: A0A674HIU5
names: Similarity
messages: Belongs to the peptidase A1 family.

59729:MIS12
gene id: 59729:MIS12
uniprot id: H0Z198
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

59729:PHB
gene id: 59729:PHB
uniprot id: B5G0C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Cell membrane
messages: Mitochondrion inner membrane

59729:TPM1
gene id: 59729:TPM1
uniprot id: A0A674HCB7
uniprot id: A0A674HN10
uniprot id: A0A674HTF0
uniprot id: B5KFH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

59729:NME2
gene id: 59729:NME2
uniprot id: B5G0H9
names: Similarity
messages: Belongs to the NDK family.

59729:MRM2
gene id: 59729:MRM2
uniprot id: H0ZCX1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

59729:GABBR2
gene id: 59729:GABBR2
uniprot id: A0A674HEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

59729:ZDHHC14
gene id: 59729:ZDHHC14
uniprot id: A0A674HU90
uniprot id: H0ZLH6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

59729:PIGU
gene id: 59729:PIGU
uniprot id: H0YYQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:F2
gene id: 59729:F2
uniprot id: H0ZJZ8
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

59729:TXN
gene id: 59729:TXN
uniprot id: B5G117
names: Similarity
messages: Belongs to the thioredoxin family.

59729:LOC100220427
gene id: 59729:LOC100220427
uniprot id: A0A674GDN7
names: Similarity
messages: Belongs to the DCK/DGK family.

59729:GREB1
gene id: 59729:GREB1
uniprot id: H0ZS76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GREB1 family.
messages: Membrane

59729:PPT1
gene id: 59729:PPT1
uniprot id: B5FZ59
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

59729:PRKAR2A
gene id: 59729:PRKAR2A
uniprot id: H0ZFR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

59729:CORT
gene id: 59729:CORT
uniprot id: B5FXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

59729:BAMBI
gene id: 59729:BAMBI
uniprot id: B5G0B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

59729:ANAPC4
gene id: 59729:ANAPC4
uniprot id: H1A1Y0
names: Function
names: Similarity
messages: Belongs to the APC4 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

59729:TMEM170B
gene id: 59729:TMEM170B
uniprot id: A0A674G9S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

59729:COPS9
gene id: 59729:COPS9
uniprot id: B5FZI1
names: Similarity
messages: Belongs to the CSN9 family.

59729:CTSB
gene id: 59729:CTSB
uniprot id: B5G358
names: Similarity
messages: Belongs to the peptidase C1 family.

59729:SGCD
gene id: 59729:SGCD
uniprot id: A0A674HNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

59729:DDT
gene id: 59729:DDT
uniprot id: B5G0R9
names: Similarity
messages: Belongs to the MIF family.

59729:ISCA2
gene id: 59729:ISCA2
uniprot id: B5FY25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

59729:TMEM87A
gene id: 59729:TMEM87A
uniprot id: H0ZLE0
names: Subcellular Location Annotation
messages: Membrane

59729:MFSD14A
gene id: 59729:MFSD14A
uniprot id: H0Z4G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane

59729:NDFIP1
gene id: 59729:NDFIP1
uniprot id: B5FYV0
names: Subcellular Location Annotation
messages: Membrane

59729:FAM53A
gene id: 59729:FAM53A
uniprot id: H0ZK48
names: Similarity
messages: Belongs to the FAM53 family.

59729:DBX2
gene id: 59729:DBX2
uniprot id: B5FX96
names: Subcellular Location Annotation
messages: Nucleus

59729:PGK1
gene id: 59729:PGK1
uniprot id: H0Z6P7
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

59729:IDI1
gene id: 59729:IDI1
uniprot id: B5G0X6
names: Function
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

59729:HOXA6
gene id: 59729:HOXA6
uniprot id: H0YXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

59729:SIM1
gene id: 59729:SIM1
uniprot id: H0ZPV8
names: Subcellular Location Annotation
messages: Nucleus

59729:PDHB
gene id: 59729:PDHB
uniprot id: B5G1H2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

59729:CZH9orf64
gene id: 59729:CZH9orf64
uniprot id: H0YY71
names: Function
names: Similarity
messages: Belongs to the queuosine salvage protein family.
messages: Involved in salvaging queuosine.

59729:BOLA1
gene id: 59729:BOLA1
uniprot id: B5G4P4
names: Similarity
messages: Belongs to the BolA/IbaG family.

59729:NMB
gene id: 59729:NMB
uniprot id: H0Z347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted

59729:OSGEP
gene id: 59729:OSGEP
uniprot id: B5FXN3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
messages: Cytoplasm
messages: Nucleus

59729:PWP2
gene id: 59729:PWP2
uniprot id: H0Z6K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

59729:RAB4A
gene id: 59729:RAB4A
uniprot id: A0A674H2S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport.

59729:TFRC
gene id: 59729:TFRC
uniprot id: A0A674GYL2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

59729:PPIP5K1
gene id: 59729:PPIP5K1
uniprot id: A0A674HEL6
uniprot id: A0A674HJQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

59729:HAGH
gene id: 59729:HAGH
uniprot id: B5FYT6
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

59729:JAKMIP2
gene id: 59729:JAKMIP2
uniprot id: H0YP47
names: Similarity
messages: Belongs to the JAKMIP family.

59729:EIF4A3
gene id: 59729:EIF4A3
uniprot id: B5FZY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Cytoplasm
messages: Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains casc3, eif4a3, magoh and rbm8a.
messages: Nucleus
messages: Nucleus speckle

59729:PHACTR1
gene id: 59729:PHACTR1
uniprot id: A0A674HGZ9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.
messages: Cytoplasm
messages: Nucleus
messages: Synapse

59729:RPL27
gene id: 59729:RPL27
uniprot id: B5FZY2
uniprot id: B5FZY5
uniprot id: B5FZY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL27 family.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum

59729:PFKFB3
gene id: 59729:PFKFB3
uniprot id: H0YUX4
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

59729:NSFL1C
gene id: 59729:NSFL1C
uniprot id: B5KFR1
names: Subcellular Location Annotation
messages: Golgi stack

59729:TMEM17
gene id: 59729:TMEM17
uniprot id: B5FXH2
names: Subcellular Location Annotation
messages: Membrane

59729:FGF2
gene id: 59729:FGF2
uniprot id: A0A674GPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Nucleus
messages: Secreted

59729:KEG28 p03
gene id: 59729:KEG28_p03
uniprot id: Q27GV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

59729:NAXE
gene id: 59729:NAXE
uniprot id: B5G185
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted

59729:NDUFB3
gene id: 59729:NDUFB3
uniprot id: B5FYG8
uniprot id: B5FYH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

59729:DICER1
gene id: 59729:DICER1
uniprot id: A0A674HKR2
names: Function
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

59729:CPLX2
gene id: 59729:CPLX2
uniprot id: B5G052
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

59729:RAP2C
gene id: 59729:RAP2C
uniprot id: H0YXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Recycling endosome membrane

59729:LOC100190722
gene id: 59729:LOC100190722
uniprot id: B5G279
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus (By simi…
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of NCBP1/CBP80 and NCBP2/CBP20 that interacts with m7GpppG-capped RNA.
messages: Cytoplasm
messages: Nucleus

59729:IRAK1BP1
gene id: 59729:IRAK1BP1
uniprot id: H0ZQT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

59729:LOC100218405
gene id: 59729:LOC100218405
uniprot id: D8FT03
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

59729:CAST
gene id: 59729:CAST
uniprot id: A0A674GF67
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I27 (calpastatin) family.
messages: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

59729:TFAP2C
gene id: 59729:TFAP2C
uniprot id: H0ZDH9
names: Similarity
messages: Belongs to the AP-2 family.

59729:NR2F2
gene id: 59729:NR2F2
uniprot id: A0A674GX41
uniprot id: B5KFS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

59729:SLC10A2
gene id: 59729:SLC10A2
uniprot id: H0ZKM1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane
messages: Monomer and homodimer.

59729:RNF170
gene id: 59729:RNF170
uniprot id: A0A674H4J4
names: Subcellular Location Annotation
messages: Membrane

59729:SEMA6A
gene id: 59729:SEMA6A
uniprot id: H1A4L4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:LOC100229375
gene id: 59729:LOC100229375
uniprot id: H0Z3C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Membrane

59729:HSPB8
gene id: 59729:HSPB8
uniprot id: H0ZG07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Displays temperature-dependent chaperone activity.

59729:MZT1
gene id: 59729:MZT1
uniprot id: B5FXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MOZART1 family.
messages: Part of the gamma-tubulin complex.
messages: Required for gamma-tubulin complex recruitment to the centrosome.
messages: centrosome
messages: spindle

59729:HOXA7
gene id: 59729:HOXA7
uniprot id: H0YXH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

59729:LOC100227575
gene id: 59729:LOC100227575
uniprot id: B5FYB1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

59729:GTF2E2
gene id: 59729:GTF2E2
uniprot id: A0A674GLB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

59729:RTN4IP1
gene id: 59729:RTN4IP1
uniprot id: H0ZPM1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

59729:RPL39
gene id: 59729:RPL39
uniprot id: B5FY19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

59729:RDX
gene id: 59729:RDX
uniprot id: A0A674HAP8
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton

59729:NPY1R
gene id: 59729:NPY1R
uniprot id: H0Z5W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:LRRC8C
gene id: 59729:LRRC8C
uniprot id: A0A674HKR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

59729:HHATL
gene id: 59729:HHATL
uniprot id: H0YPS0
names: Subcellular Location Annotation
messages: Membrane

59729:IL1R1
gene id: 59729:IL1R1
uniprot id: H0ZHY3
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

59729:PROC
gene id: 59729:PROC
uniprot id: H0ZAX9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:LOC100231893
gene id: 59729:LOC100231893
uniprot id: H0YPJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

59729:RPL7A
gene id: 59729:RPL7A
uniprot id: B5FYM8
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

59729:PHYKPL
gene id: 59729:PHYKPL
uniprot id: H1A1R5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

59729:SATB1
gene id: 59729:SATB1
uniprot id: H0YYC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

59729:RPL34
gene id: 59729:RPL34
uniprot id: B5FY45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

59729:LOC100223404
gene id: 59729:LOC100223404
uniprot id: H0ZDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

59729:EMP2
gene id: 59729:EMP2
uniprot id: H0Z2Z6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

59729:LYN
gene id: 59729:LYN
uniprot id: A0A674GFE5
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

59729:CCR5
gene id: 59729:CCR5
uniprot id: A0A674GFP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:ZNF503
gene id: 59729:ZNF503
uniprot id: H0Z837
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Elbow/Noc family.
messages: Nucleus

59729:C1H12orf57
gene id: 59729:C1H12orf57
uniprot id: B5FZA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0456 family.
messages: Cytoplasm

59729:NOP16
gene id: 59729:NOP16
uniprot id: H0YQK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

59729:LOC751972
gene id: 59729:LOC751972
uniprot id: Q9IA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

59729:PSME3
gene id: 59729:PSME3
uniprot id: B5FZN7
names: Similarity
messages: Belongs to the PA28 family.

59729:ITIH2
gene id: 59729:ITIH2
uniprot id: H0YV61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITIH family.
messages: Secreted

59729:MRPL9
gene id: 59729:MRPL9
uniprot id: B5FXJ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

59729:RORA
gene id: 59729:RORA
uniprot id: H0Z4K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

59729:NMUR1
gene id: 59729:NMUR1
uniprot id: H0ZHN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

59729:KLC1
gene id: 59729:KLC1
uniprot id: A0A674HGD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

59729:LHPP
gene id: 59729:LHPP
uniprot id: B5G164
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

59729:MAP7
gene id: 59729:MAP7
uniprot id: A0A674HGF3
names: Similarity
messages: Belongs to the MAP7 family.

59729:NR3C2
gene id: 59729:NR3C2
uniprot id: Q157N1
names: Subcellular Location Annotation
messages: Nucleus

59729:LOC100190440
gene id: 59729:LOC100190440
uniprot id: B5G293
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

59729:AP3S2
gene id: 59729:AP3S2
uniprot id: B5G417
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

59729:L3MBTL3
gene id: 59729:L3MBTL3
uniprot id: A0A674HDH6
names: Subcellular Location Annotation
messages: Nucleus

59729:EIF3H
gene id: 59729:EIF3H
uniprot id: B5FY35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

59729:C30H19orf53
gene id: 59729:C30H19orf53
uniprot id: B5FXD2
names: Similarity
messages: Belongs to the UPF0390 family.

59729:CSTB
gene id: 59729:CSTB
uniprot id: B5G158
names: Similarity
messages: Belongs to the cystatin family.

59729:PPIL4
gene id: 59729:PPIL4
uniprot id: H0ZK72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:DDOST
gene id: 59729:DDOST
uniprot id: H0YV45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

59729:NRXN3
gene id: 59729:NRXN3
uniprot id: H0ZQ41
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:LHFPL2
gene id: 59729:LHFPL2
uniprot id: H0Z065
names: Subcellular Location Annotation
messages: Membrane

59729:PITX1
gene id: 59729:PITX1
uniprot id: H0YSN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

59729:LOC100225149
gene id: 59729:LOC100225149
uniprot id: H0Z8X7
names: Subcellular Location Annotation
messages: Membrane

59729:SCT
gene id: 59729:SCT
uniprot id: F2YI30
names: Similarity
messages: Belongs to the glucagon family.

59729:MAB21L1
gene id: 59729:MAB21L1
uniprot id: H0ZNN6
names: Similarity
messages: Belongs to the mab-21 family.

59729:LOC100218691
gene id: 59729:LOC100218691
uniprot id: B5FYW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:DEGS1
gene id: 59729:DEGS1
uniprot id: A0A674GIG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.
messages: Membrane

59729:LDB3
gene id: 59729:LDB3
uniprot id: H0Z5L0
names: Subcellular Location Annotation
messages: Z line

59729:FRG1
gene id: 59729:FRG1
uniprot id: B5G1N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

59729:LOC105758694
gene id: 59729:LOC105758694
uniprot id: A0A674GDY1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

59729:SLC5A7
gene id: 59729:SLC5A7
uniprot id: H0ZHD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

59729:SERPINA10
gene id: 59729:SERPINA10
uniprot id: H1A5K6
names: Similarity
messages: Belongs to the serpin family.

59729:CHCHD4
gene id: 59729:CHCHD4
uniprot id: H0ZD63
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

59729:CDH20
gene id: 59729:CDH20
uniprot id: H0YUS1
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

59729:NSG2
gene id: 59729:NSG2
uniprot id: B5G2X4
names: Similarity
messages: Belongs to the NSG family.

59729:BTG1
gene id: 59729:BTG1
uniprot id: H0ZCZ0
names: Function
names: Similarity
messages: Anti-proliferative protein.
messages: Belongs to the BTG family.

59729:EMP1
gene id: 59729:EMP1
uniprot id: A0A674HBQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Membrane

59729:SLC7A1
gene id: 59729:SLC7A1
uniprot id: H0ZN67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

59729:HIKESHI
gene id: 59729:HIKESHI
uniprot id: B5FYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
messages: Belongs to the OPI10 family.
messages: Cytoplasm
messages: Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.
messages: Nucleus
messages: cytosol

59729:LOC100227828
gene id: 59729:LOC100227828
uniprot id: A0A674GMT5
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

59729:NDUFB5
gene id: 59729:NDUFB5
uniprot id: B5G0I5
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.

59729:SEC22B
gene id: 59729:SEC22B
uniprot id: A0A674G831
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

59729:OST4
gene id: 59729:OST4
uniprot id: B5G114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:MCM4
gene id: 59729:MCM4
uniprot id: H0ZKX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

59729:ADCY5
gene id: 59729:ADCY5
uniprot id: H0Z1K3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

59729:PPP1CA
gene id: 59729:PPP1CA
uniprot id: B5FXE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cytoplasm

59729:RFTN2
gene id: 59729:RFTN2
uniprot id: A0A674H0F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

59729:GABRD
gene id: 59729:GABRD
uniprot id: H0YXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

59729:RXRG
gene id: 59729:RXRG
uniprot id: F2Y9D4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

59729:SMARCB1
gene id: 59729:SMARCB1
uniprot id: H0ZJ65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF5 family.
messages: Component of the multiprotein chromatin-remodeling complexes SWI/SNF.
messages: Nucleus

59729:TEX10
gene id: 59729:TEX10
uniprot id: H0ZEN1
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

59729:KEG28 p06
gene id: 59729:KEG28_p06
uniprot id: Q27GW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.
messages: Mitochondrion membrane

59729:TK1
gene id: 59729:TK1
uniprot id: H0YYT9
names: Similarity
messages: Belongs to the thymidine kinase family.

59729:TSNAX
gene id: 59729:TSNAX
uniprot id: H0ZIJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

59729:GGA1
gene id: 59729:GGA1
uniprot id: H0ZJY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: trans-Golgi network membrane

59729:NUDT21
gene id: 59729:NUDT21
uniprot id: B5G2F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

59729:YIPF3
gene id: 59729:YIPF3
uniprot id: B5G146
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
messages: Membrane
messages: cis-Golgi network membrane

59729:SSR3
gene id: 59729:SSR3
uniprot id: B5FYQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

59729:NDUFS7
gene id: 59729:NDUFS7
uniprot id: B5G1Z9
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

59729:ANAPC16
gene id: 59729:ANAPC16
uniprot id: B5G162
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

59729:RALA
gene id: 59729:RALA
uniprot id: B5FXD7
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family.

59729:FAM135A
gene id: 59729:FAM135A
uniprot id: A0A674GLR2
uniprot id: H0ZR59
names: Similarity
messages: Belongs to the FAM135 family.

59729:STEAP2
gene id: 59729:STEAP2
uniprot id: A0A674GY24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

59729:PSMB7
gene id: 59729:PSMB7
uniprot id: H0Z9V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.

59729:DLK2
gene id: 59729:DLK2
uniprot id: A0A674H6C9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:PSMC1
gene id: 59729:PSMC1
uniprot id: B5FZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Nucleus

59729:LOC100189956
gene id: 59729:LOC100189956
uniprot id: B5FX72
names: Similarity
messages: Belongs to the FAH family.

59729:CHD1
gene id: 59729:CHD1
uniprot id: Q800S6
names: Subcellular Location Annotation
messages: Nucleus

59729:RPS9
gene id: 59729:RPS9
uniprot id: B5FX48
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

59729:UTP15
gene id: 59729:UTP15
uniprot id: H0Z690
names: Subcellular Location Annotation
messages: nucleolus

59729:PARK7
gene id: 59729:PARK7
uniprot id: B5G3Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

59729:GABRA6
gene id: 59729:GABRA6
uniprot id: H0YT88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

59729:ARL14
gene id: 59729:ARL14
uniprot id: H0ZLM4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

59729:PSMC5
gene id: 59729:PSMC5
uniprot id: B5G0X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

59729:PKNOX1
gene id: 59729:PKNOX1
uniprot id: A0A674HJG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

59729:CKS1B
gene id: 59729:CKS1B
uniprot id: B5FXN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

59729:SNRNP27
gene id: 59729:SNRNP27
uniprot id: B5G3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

59729:EBF2
gene id: 59729:EBF2
uniprot id: H0Z1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

59729:LOC100224389
gene id: 59729:LOC100224389
uniprot id: H0Z839
names: Similarity
messages: Belongs to the PP2C family.

59729:CRKL
gene id: 59729:CRKL
uniprot id: A0A674H0B5
names: Similarity
messages: Belongs to the CRK family.

59729:ASIP
gene id: 59729:ASIP
uniprot id: A0A674GJ99
names: Subcellular Location Annotation
messages: Secreted

59729:RPS26
gene id: 59729:RPS26
uniprot id: B5FYD8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.

59729:VWC2L
gene id: 59729:VWC2L
uniprot id: H0YXF0
names: Subcellular Location Annotation
messages: Synapse

59729:ADAM23
gene id: 59729:ADAM23
uniprot id: A0A674HP74
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:DHRS7
gene id: 59729:DHRS7
uniprot id: H0ZRZ3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

59729:MAP1LC3B
gene id: 59729:MAP1LC3B
uniprot id: B5G485
names: Similarity
messages: Belongs to the ATG8 family.

59729:WT1
gene id: 59729:WT1
uniprot id: A0A674GAA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

59729:LOC100223967
gene id: 59729:LOC100223967
uniprot id: A0A674GXX5
names: Similarity
messages: Belongs to the peptidase M14 family.

59729:SNAP25
gene id: 59729:SNAP25
uniprot id: A0A674HC91
uniprot id: A0A674HUY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.
messages: synaptosome

59729:LOC100218765
gene id: 59729:LOC100218765
uniprot id: H0Z348
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

59729:MRRF
gene id: 59729:MRRF
uniprot id: B5FXB2
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

59729:TSPAN14
gene id: 59729:TSPAN14
uniprot id: A0A674GAQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

59729:YWHAH
gene id: 59729:YWHAH
uniprot id: B5G4A6
names: Similarity
messages: Belongs to the 14-3-3 family.

59729:KCNG3
gene id: 59729:KCNG3
uniprot id: A0A674HSX3
names: Subcellular Location Annotation
messages: Membrane

59729:NDUFAF4
gene id: 59729:NDUFAF4
uniprot id: B5KFM8
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

59729:RPE65
gene id: 59729:RPE65
uniprot id: H0ZJ10
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

59729:SYS1
gene id: 59729:SYS1
uniprot id: B5FX68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYS1 family.
messages: Golgi apparatus membrane
messages: Interacts with ARFRP1.
messages: Involved in protein trafficking. May serve as a receptor for ARFRP1.
messages: Membrane

59729:IAH1
gene id: 59729:IAH1
uniprot id: H0ZS19
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

59729:EIF2S2
gene id: 59729:EIF2S2
uniprot id: A0A674GV69
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

59729:COPS7A
gene id: 59729:COPS7A
uniprot id: B5G2R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
messages: Cytoplasm
messages: Nucleus

59729:AP3S1
gene id: 59729:AP3S1
uniprot id: A0A674GSQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

59729:AHCY
gene id: 59729:AHCY
uniprot id: A0A674HNW8
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

59729:LOC100221856
gene id: 59729:LOC100221856
uniprot id: H0ZMC6
names: Similarity
messages: Belongs to the fl(2)d family.

59729:MFAP1
gene id: 59729:MFAP1
uniprot id: H0ZIT3
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

59729:SEC61G
gene id: 59729:SEC61G
uniprot id: A0A674H217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:CSTF3
gene id: 59729:CSTF3
uniprot id: H0Z3Q7
names: Subcellular Location Annotation
messages: Nucleus

59729:IDUA
gene id: 59729:IDUA
uniprot id: A0A674GVN9
names: Similarity
messages: Belongs to the glycosyl hydrolase 39 family.

59729:MOSPD1
gene id: 59729:MOSPD1
uniprot id: B5FYF0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

59729:TNFAIP1
gene id: 59729:TNFAIP1
uniprot id: H0ZEI0
names: Similarity
messages: Belongs to the BACURD family.

59729:TMSB15B
gene id: 59729:TMSB15B
uniprot id: B5G1J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

59729:TP53INP1
gene id: 59729:TP53INP1
uniprot id: A0A674H047
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

59729:TES
gene id: 59729:TES
uniprot id: H0Z4D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prickle / espinas / testin family.
messages: focal adhesion

59729:MYB
gene id: 59729:MYB
uniprot id: A0A674HPV3
uniprot id: H0ZMN3
names: Subcellular Location Annotation
messages: Nucleus

59729:ELAVL4
gene id: 59729:ELAVL4
uniprot id: A0A674GVX0
uniprot id: A0A674HD38
uniprot id: H0ZE51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm
messages: Perikaryon
messages: axon
messages: dendrite
messages: growth cone

59729:LOC100231339
gene id: 59729:LOC100231339
uniprot id: H0ZBH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
messages: Membrane

59729:EIF3K
gene id: 59729:EIF3K
uniprot id: B5FYY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm
messages: Nucleus

59729:PUS3
gene id: 59729:PUS3
uniprot id: A0A674GFE4
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

59729:STMN3
gene id: 59729:STMN3
uniprot id: B5FXL5
names: Similarity
messages: Belongs to the stathmin family.

59729:LOC100231703
gene id: 59729:LOC100231703
uniprot id: H0YT41
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.

59729:LSM3
gene id: 59729:LSM3
uniprot id: B5FXE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

59729:RPS25
gene id: 59729:RPS25
uniprot id: B5FX78
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

59729:S100A1
gene id: 59729:S100A1
uniprot id: B5FX85
names: Similarity
messages: Belongs to the S-100 family.

59729:VDAC3
gene id: 59729:VDAC3
uniprot id: B5G3N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
messages: Interacts with ARMC12 in a TBC1D21-dependent manner.
messages: Mitochondrion outer membrane

59729:UBE2A
gene id: 59729:UBE2A
uniprot id: H0YYS2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:EEF1AKMT2
gene id: 59729:EEF1AKMT2
uniprot id: H0ZMH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: Nucleus
messages: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'.

59729:KLHL15
gene id: 59729:KLHL15
uniprot id: A0A674HNR2
names: Subcellular Location Annotation
messages: Nucleus

59729:PEX12
gene id: 59729:PEX12
uniprot id: H0Z341
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Peroxisome membrane
messages: Required for protein import into peroxisomes.

59729:TUBE1
gene id: 59729:TUBE1
uniprot id: A0A674GIH4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: cytoskeleton

59729:GCLC
gene id: 59729:GCLC
uniprot id: H0ZRK0
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

59729:CRYAA
gene id: 59729:CRYAA
uniprot id: A0A674HC43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Contributes to the transparency and refractive index of the lens. May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.
messages: Cytoplasm

59729:EXOC8
gene id: 59729:EXOC8
uniprot id: H1A530
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: growth cone
messages: perinuclear region

59729:TMEM208
gene id: 59729:TMEM208
uniprot id: B5G1U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

59729:SDHA
gene id: 59729:SDHA
uniprot id: H0ZD78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

59729:MRPL14
gene id: 59729:MRPL14
uniprot id: B5G3W8
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

59729:CALHM6
gene id: 59729:CALHM6
uniprot id: H0ZNX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

59729:IFT43
gene id: 59729:IFT43
uniprot id: B5G1P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base.
messages: Belongs to the IFT43 family.
messages: Component of the IFT complex A (IFT-A) complex.
messages: cilium
messages: cytoskeleton

59729:MADD
gene id: 59729:MADD
uniprot id: H0ZJM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

59729:DDX5
gene id: 59729:DDX5
uniprot id: A0A674GR94
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

59729:PANK4
gene id: 59729:PANK4
uniprot id: H0YXF9
names: Similarity
names: Subunit
messages: Belongs to the type II pantothenate kinase family.
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.

59729:OTUD7A
gene id: 59729:OTUD7A
uniprot id: H0Z4X1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

59729:LOC100224495
gene id: 59729:LOC100224495
uniprot id: H0Z5A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

59729:PDP1
gene id: 59729:PDP1
uniprot id: A0A674HQ78
uniprot id: A0A674HU73
names: Similarity
messages: Belongs to the PP2C family.

59729:LOC100222897
gene id: 59729:LOC100222897
uniprot id: H0ZLN1
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

59729:ZIC1
gene id: 59729:ZIC1
uniprot id: H0ZET7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLI C2H2-type zinc-finger protein family.
messages: Nucleus

59729:LOC100190143
gene id: 59729:LOC100190143
uniprot id: B5FYD5
names: Similarity
messages: Belongs to the MIF family.

59729:HGD
gene id: 59729:HGD
uniprot id: H0ZT23
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

59729:DEGS2
gene id: 59729:DEGS2
uniprot id: H0ZR84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:GPR89B
gene id: 59729:GPR89B
uniprot id: H0ZTI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

59729:PDRG1
gene id: 59729:PDRG1
uniprot id: B5FYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

59729:PSMD7
gene id: 59729:PSMD7
uniprot id: B5KFF3
names: Similarity
messages: Belongs to the peptidase M67A family.

59729:LOC101233594
gene id: 59729:LOC101233594
uniprot id: B5FYW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:SNX5
gene id: 59729:SNX5
uniprot id: H0Z6C1
names: Function
names: Similarity
messages: Belongs to the sorting nexin family.
messages: Involved in several stages of intracellular trafficking.

59729:COPS2
gene id: 59729:COPS2
uniprot id: H0ZAA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN2 family.
messages: Cytoplasm
messages: Nucleus

59729:LOC100227340
gene id: 59729:LOC100227340
uniprot id: H0ZN92
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

59729:MRPL15
gene id: 59729:MRPL15
uniprot id: A0A674GT92
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

59729:LOC100190710
gene id: 59729:LOC100190710
uniprot id: B5G1B6
names: Similarity
messages: Belongs to the TMEM14 family.

59729:TATDN3
gene id: 59729:TATDN3
uniprot id: B5KFT5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

59729:BVES
gene id: 59729:BVES
uniprot id: H0ZPQ5
names: Similarity
messages: Belongs to the popeye family.

59729:LOC100221212
gene id: 59729:LOC100221212
uniprot id: A0A674HL91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

59729:PPARA
gene id: 59729:PPARA
uniprot id: H0ZNI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

59729:BCO1
gene id: 59729:BCO1
uniprot id: H0Z264
names: Similarity
messages: Belongs to the carotenoid oxygenase family.

59729:POLR2L
gene id: 59729:POLR2L
uniprot id: B5FYX6
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

59729:ACOT13
gene id: 59729:ACOT13
uniprot id: B5FXY0
names: Similarity
messages: Belongs to the thioesterase PaaI family.

59729:LUC7L3
gene id: 59729:LUC7L3
uniprot id: A0A674GGD5
uniprot id: H0ZFZ6
names: Similarity
messages: Belongs to the Luc7 family.

59729:TNFSF15
gene id: 59729:TNFSF15
uniprot id: H0YYA7
names: Similarity
messages: Belongs to the tumor necrosis factor family.

59729:LOC105759190
gene id: 59729:LOC105759190
uniprot id: H0YVE4
names: Similarity
messages: Belongs to the cornifelin family.

59729:MTR
gene id: 59729:MTR
uniprot id: H0ZJP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.
messages: Cytoplasm
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

59729:SHC1
gene id: 59729:SHC1
uniprot id: A0A674GA09
names: Subcellular Location Annotation
messages: Cytoplasm

59729:TBL1X
gene id: 59729:TBL1X
uniprot id: A0A674HKW1
names: Similarity
messages: Belongs to the WD repeat EBI family.

59729:SDC1
gene id: 59729:SDC1
uniprot id: H0ZSE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane
messages: extracellular exosome

59729:TRAPPC6B
gene id: 59729:TRAPPC6B
uniprot id: H0ZP73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

59729:PMVK
gene id: 59729:PMVK
uniprot id: B5G1H5
names: Subcellular Location Annotation
messages: cytosol

59729:LOC100190380
gene id: 59729:LOC100190380
uniprot id: Q8AYA7
names: Similarity
messages: Belongs to the HINT family.

59729:TMEM41A
gene id: 59729:TMEM41A
uniprot id: B5G1B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

59729:MYOZ2
gene id: 59729:MYOZ2
uniprot id: H0YUH7
names: Similarity
messages: Belongs to the myozenin family.

59729:DTD1
gene id: 59729:DTD1
uniprot id: B5G2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

59729:SUMO1
gene id: 59729:SUMO1
uniprot id: B5FZ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

59729:VOPP1
gene id: 59729:VOPP1
uniprot id: B5G0C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VOPP1/ECOP family.
messages: Cytoplasmic vesicle membrane
messages: Membrane

59729:EIF3J
gene id: 59729:EIF3J
uniprot id: B5G0D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Cytoplasm

59729:NPPA
gene id: 59729:NPPA
uniprot id: H0ZZV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

59729:LOC100224175
gene id: 59729:LOC100224175
uniprot id: A0A674GGT7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:LTA4H
gene id: 59729:LTA4H
uniprot id: H0ZE27
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

59729:FBXO25
gene id: 59729:FBXO25
uniprot id: A0A674GFR2
uniprot id: A0A674HL18
names: Subcellular Location Annotation
messages: Nucleus

59729:LOC100222284
gene id: 59729:LOC100222284
uniprot id: A0A674H4G9
names: Similarity
messages: Belongs to the peptidase C14A family.

59729:NEU2
gene id: 59729:NEU2
uniprot id: K0Q564
names: Miscellaneous
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.

59729:CWC15
gene id: 59729:CWC15
uniprot id: B5G3N4
names: Similarity
messages: Belongs to the CWC15 family.

59729:PPP2CA
gene id: 59729:PPP2CA
uniprot id: H0YSR6
names: Similarity
messages: Belongs to the PPP phosphatase family.

59729:RPL17
gene id: 59729:RPL17
uniprot id: Q563Y0
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

59729:PCID2
gene id: 59729:PCID2
uniprot id: H0ZFR6
names: Similarity
messages: Belongs to the CSN12 family.

59729:NUS1
gene id: 59729:NUS1
uniprot id: B5FXN7
names: Similarity
messages: Belongs to the UPP synthase family.

59729:FABP6
gene id: 59729:FABP6
uniprot id: H0YPK0
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:PVALB
gene id: 59729:PVALB
uniprot id: B5G1U4
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

59729:CDK2AP1
gene id: 59729:CDK2AP1
uniprot id: B5FY46
names: Similarity
messages: Belongs to the CDK2AP family.

59729:PSEN1
gene id: 59729:PSEN1
uniprot id: A0A674GY85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Cytoplasmic granule
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: Synapse
messages: The PAL motif is required for normal active site conformation.
messages: axon
messages: neuron projection

59729:GADD45G
gene id: 59729:GADD45G
uniprot id: A0A674GTY1
names: Similarity
messages: Belongs to the GADD45 family.

59729:LOC100222235
gene id: 59729:LOC100222235
uniprot id: H0Z817
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

59729:NSG1
gene id: 59729:NSG1
uniprot id: B5G0R0
names: Similarity
messages: Belongs to the NSG family.

59729:RPL31
gene id: 59729:RPL31
uniprot id: B5FX62
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Component of the large ribosomal subunit.

59729:MRPS33
gene id: 59729:MRPS33
uniprot id: B5G224
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

59729:MRPL19
gene id: 59729:MRPL19
uniprot id: B5FYH2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

59729:CHAC1
gene id: 59729:CHAC1
uniprot id: A0A674GYK6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

59729:ISCU
gene id: 59729:ISCU
uniprot id: B5FYX1
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

59729:FABP7
gene id: 59729:FABP7
uniprot id: H0ZNK7
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:DDC
gene id: 59729:DDC
uniprot id: H0ZC61
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

59729:RPL18A
gene id: 59729:RPL18A
uniprot id: H0Z7S1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

59729:ASRGL1
gene id: 59729:ASRGL1
uniprot id: H0ZR41
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

59729:LOC100189937
gene id: 59729:LOC100189937
uniprot id: B5FX49
names: Similarity
messages: Belongs to the TMEM14 family.

59729:FLNB
gene id: 59729:FLNB
uniprot id: H0ZAR1
names: Similarity
messages: Belongs to the filamin family.

59729:DNAJC25
gene id: 59729:DNAJC25
uniprot id: B5FXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAJC25 family.
messages: Membrane

59729:CALHM1
gene id: 59729:CALHM1
uniprot id: H0ZJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

59729:JPT1
gene id: 59729:JPT1
uniprot id: B5FZM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JUPITER family.
messages: Cytoplasm
messages: Nucleus

59729:SFMBT2
gene id: 59729:SFMBT2
uniprot id: A0A674GT18
names: Subcellular Location Annotation
messages: Nucleus

59729:SDAD1
gene id: 59729:SDAD1
uniprot id: H0YTV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

59729:LOC100190115
gene id: 59729:LOC100190115
uniprot id: B5FY74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP-beta family.
messages: Endoplasmic reticulum membrane
messages: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.
messages: Membrane
messages: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

59729:UTS2B
gene id: 59729:UTS2B
uniprot id: H0ZG50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

59729:WSCD1
gene id: 59729:WSCD1
uniprot id: H0ZF03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WSCD family.
messages: Membrane

59729:MEF2A
gene id: 59729:MEF2A
uniprot id: A0A674GB06
names: Subcellular Location Annotation
messages: Nucleus

59729:TMEM138
gene id: 59729:TMEM138
uniprot id: B5FZ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM138 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: Vacuole membrane
messages: cilium

59729:CENPS
gene id: 59729:CENPS
uniprot id: B5FYL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
messages: Nucleus
messages: kinetochore

59729:TEKT1
gene id: 59729:TEKT1
uniprot id: H0ZFD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

59729:LOC100226912
gene id: 59729:LOC100226912
uniprot id: A0A674GKX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

59729:HAO1
gene id: 59729:HAO1
uniprot id: H0Z7Q0
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

59729:FGF14
gene id: 59729:FGF14
uniprot id: H0ZKS7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

59729:GALNT14
gene id: 59729:GALNT14
uniprot id: H0Z2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

59729:ALDH1A2
gene id: 59729:ALDH1A2
uniprot id: Q9I8W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Converts retinaldehyde to retinoic acid (PubMed:10985355). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal (By similarity). Has only very low activity with benzaldehyde and acetaldehyde. Displays complete lack of activity with citral (PubMed:10985355). It is responsible for the ability of brain sites to synthesize retinoic acid. Its activity in the high vocal center (HVC) is required for the song of juvenile zebra finches to become stereotyped (PubMed:10985355).
messages: Cytoplasm
messages: Expressed in the high vocal center (HVC) which integrates auditory and motor activities and constitutes a nodal nucleus on the song system.
messages: Homotetramer.

59729:RPL8
gene id: 59729:RPL8
uniprot id: B5KFK9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

59729:LOC100222254
gene id: 59729:LOC100222254
uniprot id: B5FXR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

59729:LOC100220543
gene id: 59729:LOC100220543
uniprot id: H0ZG86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:NMBR
gene id: 59729:NMBR
uniprot id: H0ZL07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:LOC100228369
gene id: 59729:LOC100228369
uniprot id: B5FXY4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:LOC100190622
gene id: 59729:LOC100190622
uniprot id: B5FX87
names: Subcellular Location Annotation
messages: Nucleus

59729:EPHA7
gene id: 59729:EPHA7
uniprot id: A0A674GDN0
uniprot id: H0ZQ33
names: Subcellular Location Annotation
messages: Membrane

59729:DCT
gene id: 59729:DCT
uniprot id: H0ZLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane
messages: Membrane

59729:ATP5F1E
gene id: 59729:ATP5F1E
uniprot id: B5G0S9
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

59729:HSPE1
gene id: 59729:HSPE1
uniprot id: B5G465
names: Similarity
messages: Belongs to the GroES chaperonin family.

59729:TOMM7
gene id: 59729:TOMM7
uniprot id: B5G498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

59729:HBE1
gene id: 59729:HBE1
uniprot id: B5FX70
names: Similarity
messages: Belongs to the globin family.

59729:PDE9A
gene id: 59729:PDE9A
uniprot id: H0Z5P0
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

59729:RPL22L1
gene id: 59729:RPL22L1
uniprot id: B5FYE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

59729:MTIF2
gene id: 59729:MTIF2
uniprot id: H0Z9N2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

59729:ISCA1
gene id: 59729:ISCA1
uniprot id: H0YQT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

59729:LOC100228043
gene id: 59729:LOC100228043
uniprot id: H0Z3W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Secreted

59729:ASCC1
gene id: 59729:ASCC1
uniprot id: A0A674HCG5
names: Subcellular Location Annotation
messages: Cytoplasm

59729:CZH18orf32
gene id: 59729:CZH18orf32
uniprot id: B5G0I2
names: Similarity
messages: Belongs to the UPF0729 family.

59729:NTNG2
gene id: 59729:NTNG2
uniprot id: A0A674HP05
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:SCAMP5
gene id: 59729:SCAMP5
uniprot id: B5G477
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

59729:MRPL17
gene id: 59729:MRPL17
uniprot id: B5FYN0
uniprot id: B5FYN4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

59729:CMPK1
gene id: 59729:CMPK1
uniprot id: A0A674GJ51
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

59729:AGT
gene id: 59729:AGT
uniprot id: H0ZI58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serpin family.
messages: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
messages: Secreted
messages: Stimulates aldosterone release.

59729:PARL
gene id: 59729:PARL
uniprot id: B5FYH3
names: Subcellular Location Annotation
messages: Membrane

59729:RPL35
gene id: 59729:RPL35
uniprot id: B5G3L9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

59729:SLC30A6
gene id: 59729:SLC30A6
uniprot id: H0ZDW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

59729:RBP2
gene id: 59729:RBP2
uniprot id: H0Z426
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:SNX20
gene id: 59729:SNX20
uniprot id: A0A674GBN1
names: Subcellular Location Annotation
messages: Early endosome membrane
messages: Membrane

59729:RPS13
gene id: 59729:RPS13
uniprot id: B5FZH6
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

59729:LOC100223570
gene id: 59729:LOC100223570
uniprot id: A0A674H3X3
names: Subcellular Location Annotation
messages: Membrane

59729:CALHM2
gene id: 59729:CALHM2
uniprot id: H0ZJ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

59729:SLCO2A1
gene id: 59729:SLCO2A1
uniprot id: H0Z8E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:RPS15
gene id: 59729:RPS15
uniprot id: B5FXX7
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

59729:SOAT1
gene id: 59729:SOAT1
uniprot id: A0A674GMA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:RAB14
gene id: 59729:RAB14
uniprot id: B5G1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Recycling endosome
messages: phagosome
messages: trans-Golgi network membrane

59729:TPI1
gene id: 59729:TPI1
uniprot id: B5KFL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.
messages: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
messages: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.

59729:GTF2A2
gene id: 59729:GTF2A2
uniprot id: B5FXF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

59729:CYRIB
gene id: 59729:CYRIB
uniprot id: A0A674HDP9
uniprot id: H0ZQJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

59729:CFAP206
gene id: 59729:CFAP206
uniprot id: H0ZQD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP206 family.
messages: cilium axoneme
messages: cilium basal body

59729:NDUFB1
gene id: 59729:NDUFB1
uniprot id: B5FY00
uniprot id: B5FY01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:RANBP10
gene id: 59729:RANBP10
uniprot id: H0Z4E2
names: Similarity
messages: Belongs to the RANBP9/10 family.

59729:MTFR2
gene id: 59729:MTFR2
uniprot id: H0ZKP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

59729:NDUFA2
gene id: 59729:NDUFA2
uniprot id: B5FZL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:LOC105758848
gene id: 59729:LOC105758848
uniprot id: A0A674GJT7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:PDE7A
gene id: 59729:PDE7A
uniprot id: A0A674HNZ5
uniprot id: H0ZLY6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

59729:ODC1
gene id: 59729:ODC1
uniprot id: H0ZS38
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

59729:LOC100228770
gene id: 59729:LOC100228770
uniprot id: H0Z1H9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:RUNX2
gene id: 59729:RUNX2
uniprot id: H0ZSP5
names: Subcellular Location Annotation
messages: Nucleus

59729:ANP32A
gene id: 59729:ANP32A
uniprot id: A0A674GQF9
uniprot id: B5FYC6
names: Similarity
messages: Belongs to the ANP32 family.

59729:EXOC7
gene id: 59729:EXOC7
uniprot id: H0ZCL0
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

59729:LOC100225066
gene id: 59729:LOC100225066
uniprot id: A0A674HPM4
names: Similarity
messages: Belongs to the folate receptor family.

59729:EMC4
gene id: 59729:EMC4
uniprot id: B5G207
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:LOC100218258
gene id: 59729:LOC100218258
uniprot id: H0ZRL7
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

59729:LOC100225542
gene id: 59729:LOC100225542
uniprot id: A0A674HD88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

59729:GPR183
gene id: 59729:GPR183
uniprot id: H0ZL26
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:HEBP2
gene id: 59729:HEBP2
uniprot id: A0A674HKQ2
names: Similarity
messages: Belongs to the HEBP family.

59729:LOC100220586
gene id: 59729:LOC100220586
uniprot id: B5FYF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

59729:CAVIN4
gene id: 59729:CAVIN4
uniprot id: A0A674H1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola
messages: sarcomere

59729:LPAR1
gene id: 59729:LPAR1
uniprot id: A0A674GJ60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cell surface
messages: Endosome
messages: Membrane

59729:IGF2
gene id: 59729:IGF2
uniprot id: O57687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

59729:FHL5
gene id: 59729:FHL5
uniprot id: H0ZPZ6
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

59729:PSMA5
gene id: 59729:PSMA5
uniprot id: B5FYJ2
uniprot id: B5KFM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

59729:ITM2A
gene id: 59729:ITM2A
uniprot id: B5KFF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

59729:TRIM32
gene id: 59729:TRIM32
uniprot id: H0YYP5
names: Similarity
messages: Belongs to the TRIM/RBCC family.

59729:AARS2
gene id: 59729:AARS2
uniprot id: H0ZC41
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

59729:RPS27L
gene id: 59729:RPS27L
uniprot id: B5FYJ9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

59729:PDPR
gene id: 59729:PDPR
uniprot id: H0Z783
names: Similarity
messages: Belongs to the GcvT family.

59729:MTX2
gene id: 59729:MTX2
uniprot id: B5FXM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

59729:FAM110B
gene id: 59729:FAM110B
uniprot id: H0ZLI7
names: Similarity
messages: Belongs to the FAM110 family.

59729:PSMA3
gene id: 59729:PSMA3
uniprot id: B5G1N7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

59729:CMBL
gene id: 59729:CMBL
uniprot id: H0ZB89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

59729:HACD4
gene id: 59729:HACD4
uniprot id: H0Z1D9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:PPP1R14C
gene id: 59729:PPP1R14C
uniprot id: A0A674GQB4
names: Similarity
messages: Belongs to the PP1 inhibitor family.

59729:SCAMP1
gene id: 59729:SCAMP1
uniprot id: Q0VHR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

59729:AQP1
gene id: 59729:AQP1
uniprot id: A0A674HCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

59729:PSMB3
gene id: 59729:PSMB3
uniprot id: B5G0S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

59729:CDR2
gene id: 59729:CDR2
uniprot id: A0A674HRF6
names: Similarity
messages: Belongs to the CDR2 family.

59729:AQR
gene id: 59729:AQR
uniprot id: A0A674H803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWF11 family.
messages: Nucleus

59729:SIX6
gene id: 59729:SIX6
uniprot id: H0ZRY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIX/Sine oculis homeobox family.
messages: Nucleus

59729:HOXA13
gene id: 59729:HOXA13
uniprot id: H0YXI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

59729:LOC100223925
gene id: 59729:LOC100223925
uniprot id: A0A674GQN3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

59729:HTRA3
gene id: 59729:HTRA3
uniprot id: H0ZJ14
names: Similarity
messages: Belongs to the peptidase S1C family.

59729:TMEM230
gene id: 59729:TMEM230
uniprot id: B5FZ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM134/TMEM230 family.
messages: Early endosome
messages: Endosome
messages: Involved in trafficking and recycling of synaptic vesicles.
messages: Late endosome
messages: Membrane
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: synaptic vesicle
messages: trans-Golgi network

59729:TFAP2D
gene id: 59729:TFAP2D
uniprot id: A0A674HP36
names: Similarity
messages: Belongs to the AP-2 family.

59729:TOP2B
gene id: 59729:TOP2B
uniprot id: A0A674HNR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Homodimer.
messages: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.
messages: nucleolus
messages: nucleoplasm

59729:SOX10
gene id: 59729:SOX10
uniprot id: H0ZJN2
names: Subcellular Location Annotation
messages: Nucleus

59729:MED6
gene id: 59729:MED6
uniprot id: B5FYR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:RO60
gene id: 59729:RO60
uniprot id: H0Z128
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

59729:TECRL
gene id: 59729:TECRL
uniprot id: H0YXI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

59729:DYNLL1
gene id: 59729:DYNLL1
uniprot id: B5G0P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

59729:UBE2D1
gene id: 59729:UBE2D1
uniprot id: H0Z408
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:MRPS23
gene id: 59729:MRPS23
uniprot id: B5FYB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Mitochondrion

59729:ST8SIA5
gene id: 59729:ST8SIA5
uniprot id: A0A674H8M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

59729:SCD
gene id: 59729:SCD
uniprot id: A0A674H3V0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

59729:GPT2
gene id: 59729:GPT2
uniprot id: H0ZEU3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

59729:QRFPR
gene id: 59729:QRFPR
uniprot id: F5HPR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:LOC100222067
gene id: 59729:LOC100222067
uniprot id: H0ZRV3
names: Subcellular Location Annotation
messages: Membrane

59729:LOC100232533
gene id: 59729:LOC100232533
uniprot id: A0A674HCE2
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

59729:GNA12
gene id: 59729:GNA12
uniprot id: A0A674G7Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

59729:MINAR1
gene id: 59729:MINAR1
uniprot id: H0ZCM9
names: Similarity
messages: Belongs to the MINAR family.

59729:IFI6
gene id: 59729:IFI6
uniprot id: B5G1Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

59729:GRIN2B
gene id: 59729:GRIN2B
uniprot id: H0ZGP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
messages: Synaptic cell membrane

59729:PDLIM3
gene id: 59729:PDLIM3
uniprot id: A0A674H1T0
uniprot id: H0Z906
names: Subcellular Location Annotation
messages: Z line

59729:ARPC2
gene id: 59729:ARPC2
uniprot id: B5G418
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

59729:PSMC2
gene id: 59729:PSMC2
uniprot id: B5G2S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm

59729:LOC100221517
gene id: 59729:LOC100221517
uniprot id: H0YQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

59729:SLC34A2
gene id: 59729:SLC34A2
uniprot id: H0ZG96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Involved in actively transporting phosphate into cells via Na(+) cotransport.
messages: Membrane

59729:ESR1
gene id: 59729:ESR1
uniprot id: Q91250
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer. Can form a heterodimer with ER-beta (By similarity).
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

59729:IMP4
gene id: 59729:IMP4
uniprot id: B5FXR7
names: Subcellular Location Annotation
messages: nucleolus

59729:PALS1
gene id: 59729:PALS1
uniprot id: A0A674HS90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

59729:TRMT6
gene id: 59729:TRMT6
uniprot id: H0YVE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

59729:MRPL42
gene id: 59729:MRPL42
uniprot id: B5FXK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL42 family.
messages: Mitochondrion

59729:IFNG
gene id: 59729:IFNG
uniprot id: A0A674HE98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
messages: Secreted

59729:ITGB6
gene id: 59729:ITGB6
uniprot id: H0Z879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

59729:ACTC1
gene id: 59729:ACTC1
uniprot id: H0ZNH2
names: Similarity
messages: Belongs to the actin family.

59729:OXTR
gene id: 59729:OXTR
uniprot id: A0A674GUK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane

59729:HOXA4
gene id: 59729:HOXA4
uniprot id: H0YXG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

59729:LAMP5
gene id: 59729:LAMP5
uniprot id: A0A674GQU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

59729:LOC100222525
gene id: 59729:LOC100222525
uniprot id: A0A674H2G8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

59729:MGST1
gene id: 59729:MGST1
uniprot id: B5G0B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

59729:LOC100221986
gene id: 59729:LOC100221986
uniprot id: H0ZAD9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:RPS20
gene id: 59729:RPS20
uniprot id: H0ZLG5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the 40S small ribosomal subunit.

59729:PTH
gene id: 59729:PTH
uniprot id: H1A031
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
messages: Secreted

59729:MRPL30
gene id: 59729:MRPL30
uniprot id: B5FZK5
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

59729:LOC100189939
gene id: 59729:LOC100189939
uniprot id: B5FX51
names: Similarity
messages: Belongs to the COX20 family.

59729:ARV1
gene id: 59729:ARV1
uniprot id: A0A674GEA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane

59729:ATIC
gene id: 59729:ATIC
uniprot id: H0YXN8
names: Similarity
messages: Belongs to the PurH family.

59729:LLPH
gene id: 59729:LLPH
uniprot id: A0A674GIQ4
names: Similarity
messages: Belongs to the learning-associated protein family.

59729:SDF4
gene id: 59729:SDF4
uniprot id: A0A674GP65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREC family.
messages: Golgi apparatus lumen

59729:LOC100224416
gene id: 59729:LOC100224416
uniprot id: B5FYW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:LOC105758846
gene id: 59729:LOC105758846
uniprot id: A0A674H6Y7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:NAPG
gene id: 59729:NAPG
uniprot id: A0A674HKS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

59729:LOC100230788
gene id: 59729:LOC100230788
uniprot id: H0ZDD6
names: Similarity
messages: Belongs to the amidase family.

59729:MAPK9
gene id: 59729:MAPK9
uniprot id: A0A674H119
uniprot id: A0A674HMU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

59729:RPLP0
gene id: 59729:RPLP0
uniprot id: H0ZGQ3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

59729:CLDN18
gene id: 59729:CLDN18
uniprot id: A0A674H6D9
uniprot id: H0Z8X9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

59729:STMN1
gene id: 59729:STMN1
uniprot id: B5G2Z4
names: Similarity
messages: Belongs to the stathmin family.

59729:DRD1
gene id: 59729:DRD1
uniprot id: H0YPZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:AFF4
gene id: 59729:AFF4
uniprot id: A0A674GNB8
names: Similarity
messages: Belongs to the AF4 family.

59729:ORC3
gene id: 59729:ORC3
uniprot id: H0ZQB9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

59729:CHD1W
gene id: 59729:CHD1W
uniprot id: Q7ZT34
names: Subcellular Location Annotation
messages: Nucleus

59729:PRKCQ
gene id: 59729:PRKCQ
uniprot id: H0YUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

59729:MTNR1B
gene id: 59729:MTNR1B
uniprot id: Q3LTL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:LOC100222415
gene id: 59729:LOC100222415
uniprot id: H0ZHD0
names: Similarity
messages: Belongs to the cytochrome P450 family.

59729:SLC25A47
gene id: 59729:SLC25A47
uniprot id: A0A674HUG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:RTN4
gene id: 59729:RTN4
uniprot id: A0A674HBF9
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:UCHL1
gene id: 59729:UCHL1
uniprot id: Q4ZIS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C12 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:CXCL12
gene id: 59729:CXCL12
uniprot id: B5FX95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

59729:PEX13
gene id: 59729:PEX13
uniprot id: H0Z8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-13 family.
messages: Membrane
messages: Peroxisome membrane

59729:GLYR1
gene id: 59729:GLYR1
uniprot id: A0A674GYC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIBADH-related family. NP60 subfamily.
messages: Chromosome

59729:REEP5
gene id: 59729:REEP5
uniprot id: B5G1U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

59729:ERG
gene id: 59729:ERG
uniprot id: A0A674G9K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

59729:ACADL
gene id: 59729:ACADL
uniprot id: H0ZMD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

59729:PIGO
gene id: 59729:PIGO
uniprot id: H0YU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:JUN
gene id: 59729:JUN
uniprot id: H0ZHC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

59729:POLR2I
gene id: 59729:POLR2I
uniprot id: B5FX75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

59729:LMNB2
gene id: 59729:LMNB2
uniprot id: H0YP57
names: Similarity
messages: Belongs to the intermediate filament family.

59729:LOC100225627
gene id: 59729:LOC100225627
uniprot id: F2Y9D5
names: Similarity
messages: Belongs to the cytochrome P450 family.

59729:YAF2
gene id: 59729:YAF2
uniprot id: A0A674HML7
names: Subcellular Location Annotation
messages: Nucleus

59729:LOC100224950
gene id: 59729:LOC100224950
uniprot id: A0A674GI06
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

59729:ELOVL2
gene id: 59729:ELOVL2
uniprot id: B5G3Z3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

59729:HTR5A
gene id: 59729:HTR5A
uniprot id: H0YQZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:GMFB
gene id: 59729:GMFB
uniprot id: A0A674HSE9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

59729:TMEM189
gene id: 59729:TMEM189
uniprot id: B5FY07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

59729:HSPA4
gene id: 59729:HSPA4
uniprot id: H0YPI8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

59729:NUP93
gene id: 59729:NUP93
uniprot id: A0A674GR74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

59729:HSPA2
gene id: 59729:HSPA2
uniprot id: H0ZRS0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

59729:CTNNBIP1
gene id: 59729:CTNNBIP1
uniprot id: H0YZH4
names: Similarity
messages: Belongs to the CTNNBIP1 family.

59729:ERLEC1
gene id: 59729:ERLEC1
uniprot id: H0ZA92
names: Subcellular Location Annotation
messages: Endoplasmic reticulum lumen

59729:PPIL1
gene id: 59729:PPIL1
uniprot id: B5FXA7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:RPS8
gene id: 59729:RPS8
uniprot id: B5FZC2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

59729:SEC22A
gene id: 59729:SEC22A
uniprot id: H0Z1M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

59729:LPAR6
gene id: 59729:LPAR6
uniprot id: H0ZPQ3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:LOC100221272
gene id: 59729:LOC100221272
uniprot id: H0YZU7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:SLC25A33
gene id: 59729:SLC25A33
uniprot id: B5FZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:RPS18
gene id: 59729:RPS18
uniprot id: B5FXB5
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

59729:TMEM39A
gene id: 59729:TMEM39A
uniprot id: H0ZT45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM39 family.
messages: Membrane

59729:PCYT1B
gene id: 59729:PCYT1B
uniprot id: B5FXG8
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

59729:MAGOH
gene id: 59729:MAGOH
uniprot id: B5KFL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

59729:BUD31
gene id: 59729:BUD31
uniprot id: B5FY87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

59729:GPN3
gene id: 59729:GPN3
uniprot id: B5FX60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

59729:TENT5D
gene id: 59729:TENT5D
uniprot id: H0ZXU6
names: Similarity
messages: Belongs to the TENT family.

59729:MID1
gene id: 59729:MID1
uniprot id: A0A674GF72
names: Function
names: Subcellular Location Annotation
messages: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
messages: cytoskeleton

59729:BCL2
gene id: 59729:BCL2
uniprot id: A0A674GNG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion outer membrane
messages: Nucleus membrane

59729:MEA1
gene id: 59729:MEA1
uniprot id: H0Z3D2
names: Function
messages: May play an important role in spermatogenesis and/or testis development.

59729:PPCS
gene id: 59729:PPCS
uniprot id: B5FXZ6
names: Similarity
messages: Belongs to the PPC synthetase family.

59729:NDUFB6
gene id: 59729:NDUFB6
uniprot id: B5FXY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:FBLN5
gene id: 59729:FBLN5
uniprot id: H0ZQN6
names: Caution
names: Similarity
messages: Belongs to the fibulin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:LOC100223776
gene id: 59729:LOC100223776
uniprot id: A0A674GYF4
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Heterodimer of a light chain and a heavy chain linked by a disulfide bond.
messages: Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:CDC73
gene id: 59729:CDC73
uniprot id: A0A674GIB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC73 family.
messages: Nucleus

59729:NUP50
gene id: 59729:NUP50
uniprot id: H0ZNQ1
names: Subcellular Location Annotation
messages: nuclear pore complex

59729:CLCN4
gene id: 59729:CLCN4
uniprot id: H0ZDM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

59729:PSMB4
gene id: 59729:PSMB4
uniprot id: B5G4G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

59729:DLX6
gene id: 59729:DLX6
uniprot id: H0YTS4
names: Subcellular Location Annotation
messages: Nucleus

59729:AKR1A1
gene id: 59729:AKR1A1
uniprot id: H0ZCF8
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the aldo/keto reductase family.
messages: Cell membrane
messages: Membrane
messages: cytosol

59729:KEG28 p05
gene id: 59729:KEG28_p05
uniprot id: Q27GW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

59729:NOL6
gene id: 59729:NOL6
uniprot id: H0YTW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

59729:GMPPA
gene id: 59729:GMPPA
uniprot id: A0A674GRC0
uniprot id: A0A674HLF9
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

59729:HEXIM1
gene id: 59729:HEXIM1
uniprot id: B5FXM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

59729:SEM1
gene id: 59729:SEM1
uniprot id: B5G0H4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

59729:ZRANB1
gene id: 59729:ZRANB1
uniprot id: H0ZMI9
names: Similarity
messages: Belongs to the peptidase C64 family.

59729:GPBP1
gene id: 59729:GPBP1
uniprot id: A0A674HCH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vasculin family.
messages: Nucleus

59729:ARPC3
gene id: 59729:ARPC3
uniprot id: B5FZ67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

59729:CYBASC3
gene id: 59729:CYBASC3
uniprot id: B5FX86
names: Subcellular Location Annotation
messages: Membrane

59729:PRR5
gene id: 59729:PRR5
uniprot id: H0ZNE0
names: Similarity
messages: Belongs to the PROTOR family.

59729:TMEM184C
gene id: 59729:TMEM184C
uniprot id: H0YWM1
names: Subcellular Location Annotation
messages: Membrane

59729:MBTPS1
gene id: 59729:MBTPS1
uniprot id: H0Z8L6
names: Similarity
messages: Belongs to the peptidase S8 family.

59729:SPI1
gene id: 59729:SPI1
uniprot id: A0A674GRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

59729:LOC100219287
gene id: 59729:LOC100219287
uniprot id: H0ZNA7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

59729:GSK3B
gene id: 59729:GSK3B
uniprot id: A0A674H1L5
uniprot id: H0ZT29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.
messages: Cytoplasm
messages: Nucleus

59729:KDM5A
gene id: 59729:KDM5A
uniprot id: H0ZQX3
names: Similarity
messages: Belongs to the JARID1 histone demethylase family.

59729:TGIF1
gene id: 59729:TGIF1
uniprot id: A0A674GY35
names: Subcellular Location Annotation
messages: Nucleus

59729:MADCAM1
gene id: 59729:MADCAM1
uniprot id: A0A674H5V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

59729:NDUFA10
gene id: 59729:NDUFA10
uniprot id: B5G1H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA10 subunit family.
messages: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
messages: Mitochondrion matrix

59729:SLC18A2
gene id: 59729:SLC18A2
uniprot id: H0ZLD6
names: Subcellular Location Annotation
messages: Membrane

59729:NDRG1
gene id: 59729:NDRG1
uniprot id: A0A674G7R1
names: Similarity
messages: Belongs to the NDRG family.

59729:LOC100228221
gene id: 59729:LOC100228221
uniprot id: A0A674HFR6
names: Similarity
messages: Belongs to the cytochrome b5 family.

59729:ZGPAT
gene id: 59729:ZGPAT
uniprot id: A0A674H806
names: Subcellular Location Annotation
messages: Nucleus

59729:POLB
gene id: 59729:POLB
uniprot id: H0Z558
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

59729:NKX2-5
gene id: 59729:NKX2-5
uniprot id: A0A674GFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NK-2 homeobox family.
messages: Nucleus

59729:TH
gene id: 59729:TH
uniprot id: H0ZG94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
messages: axon
messages: perinuclear region

59729:CZIB
gene id: 59729:CZIB
uniprot id: B5G1B4
names: Similarity
messages: Belongs to the UPF0587 family.

59729:SLC16A6
gene id: 59729:SLC16A6
uniprot id: H0Z123
names: Subcellular Location Annotation
messages: Membrane

59729:CD93
gene id: 59729:CD93
uniprot id: H0ZAY1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:PDCL
gene id: 59729:PDCL
uniprot id: H0Z924
names: Similarity
messages: Belongs to the phosducin family.

59729:ERRFI1
gene id: 59729:ERRFI1
uniprot id: H0YWC1
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

59729:C17H9orf78
gene id: 59729:C17H9orf78
uniprot id: H0Z236
names: Similarity
messages: Belongs to the TLS1 family.

59729:IMPACT
gene id: 59729:IMPACT
uniprot id: H0ZJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

59729:RGS1
gene id: 59729:RGS1
uniprot id: A0A674HN71
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cytosol

59729:WASHC5
gene id: 59729:WASHC5
uniprot id: H0ZQI1
names: Similarity
messages: Belongs to the strumpellin family.

59729:LPGAT1
gene id: 59729:LPGAT1
uniprot id: A0A674G8J3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

59729:LOC100219971
gene id: 59729:LOC100219971
uniprot id: B5FYJ7
names: Similarity
messages: Belongs to the cytochrome b5 family.

59729:SCG2
gene id: 59729:SCG2
uniprot id: H0ZC27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

59729:MED21
gene id: 59729:MED21
uniprot id: B5G0X4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:MLF2
gene id: 59729:MLF2
uniprot id: B5G497
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

59729:ENPP3
gene id: 59729:ENPP3
uniprot id: H0ZN45
names: Subcellular Location Annotation
messages: Secreted

59729:DGKB
gene id: 59729:DGKB
uniprot id: A0A674G776
uniprot id: A0A674GN14
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

59729:MRPL51
gene id: 59729:MRPL51
uniprot id: B5G129
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.

59729:PSMA7
gene id: 59729:PSMA7
uniprot id: B5G183
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

59729:CLTCL1
gene id: 59729:CLTCL1
uniprot id: A0A674GN64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

59729:MRPS11
gene id: 59729:MRPS11
uniprot id: B5G490
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

59729:SLC1A3
gene id: 59729:SLC1A3
uniprot id: H0YUY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

59729:NPY5R
gene id: 59729:NPY5R
uniprot id: A0A674GZ65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane
messages: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.

59729:TPM3
gene id: 59729:TPM3
uniprot id: A0A674H4Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

59729:CD40
gene id: 59729:CD40
uniprot id: H0Z5Z9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:B3GNT7
gene id: 59729:B3GNT7
uniprot id: B5FXB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

59729:LAMTOR2
gene id: 59729:LAMTOR2
uniprot id: B5FYY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAMAD family.
messages: Late endosome membrane
messages: Lysosome membrane
messages: Part of the Ragulator complex composed of lamtor1, lamtor2, lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with slc38a9; the probable amino acid sensor. Component of the lysosomal folliculin complex (LFC).
messages: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).

59729:DMAC2L
gene id: 59729:DMAC2L
uniprot id: H0ZSH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP synthase subunit s family.
messages: Homotetramer. Associates with ATP synthase.
messages: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
messages: Membrane
messages: Mitochondrion inner membrane

59729:LWS
gene id: 59729:LWS
uniprot id: Q9IA33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

59729:PRPH2
gene id: 59729:PRPH2
uniprot id: A0A674H5M6
names: Similarity
messages: Belongs to the PRPH2/ROM1 family.

59729:RTCB
gene id: 59729:RTCB
uniprot id: H0ZL18
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

59729:PENK
gene id: 59729:PENK
uniprot id: B5FXU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the opioid neuropeptide precursor family.
messages: Secreted

59729:SLC25A25
gene id: 59729:SLC25A25
uniprot id: A0A674H2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

59729:NRN1
gene id: 59729:NRN1
uniprot id: D2KZY5
names: Similarity
messages: Belongs to the neuritin family.

59729:KEG28 p09
gene id: 59729:KEG28_p09
uniprot id: Q27GW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Membrane
messages: Mitochondrion membrane

59729:LOC100222674
gene id: 59729:LOC100222674
uniprot id: H0YXV3
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:RPL14
gene id: 59729:RPL14
uniprot id: B5FXD9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

59729:LOC100221944
gene id: 59729:LOC100221944
uniprot id: B5FXC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:TSSC4
gene id: 59729:TSSC4
uniprot id: H0ZG26
names: Similarity
messages: Belongs to the TSSC4 family.

59729:ATG12
gene id: 59729:ATG12
uniprot id: B5FX55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Ubiquitin-like protein involved in autophagic vesicle formation.

59729:CLTA
gene id: 59729:CLTA
uniprot id: A0A674GRU1
uniprot id: B5FYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

59729:PEX5L
gene id: 59729:PEX5L
uniprot id: A0A674GAN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal targeting signal receptor family.
messages: Cytoplasm
messages: Membrane

59729:ARL1
gene id: 59729:ARL1
uniprot id: B5FY69
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

59729:AK3
gene id: 59729:AK3
uniprot id: B5FYH4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

59729:SIGMAR1
gene id: 59729:SIGMAR1
uniprot id: A0A674GIJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle

59729:TMA16
gene id: 59729:TMA16
uniprot id: A0A674H172
names: Function
names: Similarity
names: Subunit
messages: Associates with pre-60S ribosomal particles.
messages: Belongs to the TMA16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.

59729:NEUROD6
gene id: 59729:NEUROD6
uniprot id: H0YUK0
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

59729:SELENOK
gene id: 59729:SELENOK
uniprot id: B5G034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein K family.
messages: Endoplasmic reticulum membrane

59729:INTS14
gene id: 59729:INTS14
uniprot id: H0ZVU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

59729:ATP6AP2
gene id: 59729:ATP6AP2
uniprot id: H0Z8C1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Lysosome membrane
messages: Membrane
messages: autophagosome membrane
messages: clathrin-coated vesicle membrane
messages: dendritic spine membrane
messages: synaptic vesicle membrane

59729:TMEM120B
gene id: 59729:TMEM120B
uniprot id: B5KFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

59729:HOXA10
gene id: 59729:HOXA10
uniprot id: H0YXI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

59729:SPRY2
gene id: 59729:SPRY2
uniprot id: H0ZQS4
names: Similarity
messages: Belongs to the sprouty family.

59729:DNAJA1
gene id: 59729:DNAJA1
uniprot id: B5G121
names: Subcellular Location Annotation
messages: Membrane

59729:HSPB1
gene id: 59729:HSPB1
uniprot id: H0Z2A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: spindle

59729:LOC100218635
gene id: 59729:LOC100218635
uniprot id: H0ZG86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:UBE2R2
gene id: 59729:UBE2R2
uniprot id: B5FYL2
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:PHETA2
gene id: 59729:PHETA2
uniprot id: A0A674HE44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

59729:LOC100217866
gene id: 59729:LOC100217866
uniprot id: H0Z576
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

59729:PIGN
gene id: 59729:PIGN
uniprot id: H0YUT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

59729:HCRTR2
gene id: 59729:HCRTR2
uniprot id: H0ZRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:RPL9
gene id: 59729:RPL9
uniprot id: B5FYQ8
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

59729:ITPA
gene id: 59729:ITPA
uniprot id: B5FZM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

59729:NFU1
gene id: 59729:NFU1
uniprot id: B5FZQ4
names: Similarity
messages: Belongs to the NifU family.

59729:TBCE
gene id: 59729:TBCE
uniprot id: H0ZJ32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

59729:HBAD
gene id: 59729:HBAD
uniprot id: B5FXM1
names: Similarity
messages: Belongs to the globin family.

59729:KCNE4
gene id: 59729:KCNE4
uniprot id: A0A674GBP9
names: Similarity
messages: Belongs to the potassium channel KCNE family.

59729:GRB2
gene id: 59729:GRB2
uniprot id: B5FZR7
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

59729:LOC100225898
gene id: 59729:LOC100225898
uniprot id: A0A674H7C0
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:ATP1B2
gene id: 59729:ATP1B2
uniprot id: B5G4P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

59729:SCMH1
gene id: 59729:SCMH1
uniprot id: A0A674GKN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

59729:MRPL23
gene id: 59729:MRPL23
uniprot id: B5G200
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

59729:NCDN
gene id: 59729:NCDN
uniprot id: H0YTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

59729:CAMK2N1
gene id: 59729:CAMK2N1
uniprot id: B5G2Q7
names: Similarity
messages: Belongs to the CAMK2N family.

59729:ESRP1
gene id: 59729:ESRP1
uniprot id: H0ZNU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESRP family.
messages: Nucleus

59729:NDUFA11
gene id: 59729:NDUFA11
uniprot id: B5G3M2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:SLC6A14
gene id: 59729:SLC6A14
uniprot id: A0A674HIJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

59729:NAPB
gene id: 59729:NAPB
uniprot id: H0ZAV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

59729:MTX3
gene id: 59729:MTX3
uniprot id: H0YZJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

59729:HS3ST5
gene id: 59729:HS3ST5
uniprot id: H0ZNZ3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

59729:FGF10
gene id: 59729:FGF10
uniprot id: A0A674H506
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

59729:LOC100190731
gene id: 59729:LOC100190731
uniprot id: B5G2T6
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

59729:CLRN2
gene id: 59729:CLRN2
uniprot id: A0A674HGM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

59729:SGCG
gene id: 59729:SGCG
uniprot id: A0A674GYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: cytoskeleton
messages: sarcolemma

59729:ARL6
gene id: 59729:ARL6
uniprot id: A0A674GAZ9
uniprot id: H0ZTF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: cilium membrane

59729:MRPL12
gene id: 59729:MRPL12
uniprot id: B5FZ07
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

59729:C1GALT1
gene id: 59729:C1GALT1
uniprot id: H0YTV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
messages: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
messages: Membrane

59729:GPR52
gene id: 59729:GPR52
uniprot id: A0A674HBK4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:SEPHS1
gene id: 59729:SEPHS1
uniprot id: A0A674HNH9
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

59729:RAB27A
gene id: 59729:RAB27A
uniprot id: A0A674GLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Endosome
messages: Late endosome
messages: Membrane

59729:ALDH3A2
gene id: 59729:ALDH3A2
uniprot id: B5FYG0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

59729:CCT8
gene id: 59729:CCT8
uniprot id: H0ZTP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: cilium basal body

59729:DHDDS
gene id: 59729:DHDDS
uniprot id: H0YRZ9
names: Similarity
messages: Belongs to the UPP synthase family.

59729:GPNMB
gene id: 59729:GPNMB
uniprot id: H0YX20
names: Similarity
messages: Belongs to the PMEL/NMB family.

59729:NR5A1
gene id: 59729:NR5A1
uniprot id: Q90XC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

59729:SMC3
gene id: 59729:SMC3
uniprot id: H0ZK71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
messages: Nucleus
messages: centromere

59729:UCHL3
gene id: 59729:UCHL3
uniprot id: H0ZQL5
names: Similarity
messages: Belongs to the peptidase C12 family.

59729:CCDC126
gene id: 59729:CCDC126
uniprot id: A0A674GUD3
names: Subcellular Location Annotation
messages: Secreted

59729:ATP5MC1
gene id: 59729:ATP5MC1
uniprot id: B5FXH5
names: Caution
names: Similarity
messages: Belongs to the ATPase C chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:ETFRF1
gene id: 59729:ETFRF1
uniprot id: B5FXA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).
messages: Belongs to the complex I LYR family.
messages: Mitochondrion

59729:CER1
gene id: 59729:CER1
uniprot id: H0Z2F5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:SLC35F1
gene id: 59729:SLC35F1
uniprot id: A0A674GLR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

59729:TMEM178B
gene id: 59729:TMEM178B
uniprot id: A0A674HJA1
names: Similarity
messages: Belongs to the TMEM178 family.

59729:CUL4B
gene id: 59729:CUL4B
uniprot id: H0YZC4
names: Similarity
messages: Belongs to the cullin family.

59729:SPON1
gene id: 59729:SPON1
uniprot id: A0A674H999
names: Subcellular Location Annotation
messages: extracellular matrix

59729:FRK
gene id: 59729:FRK
uniprot id: H0ZNZ2
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

59729:CDK7
gene id: 59729:CDK7
uniprot id: H0ZVE4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

59729:FGF8
gene id: 59729:FGF8
uniprot id: H0ZI62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

59729:CCDC47
gene id: 59729:CCDC47
uniprot id: H0YUM5
names: Subcellular Location Annotation
messages: Membrane
messages: Rough endoplasmic reticulum membrane

59729:COX6A1
gene id: 59729:COX6A1
uniprot id: B5G2I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

59729:RPL11
gene id: 59729:RPL11
uniprot id: H0YSI9
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

59729:LSM6
gene id: 59729:LSM6
uniprot id: B5FY51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

59729:EGR1
gene id: 59729:EGR1
uniprot id: A0MWD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus
messages: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death.

59729:KDELR3
gene id: 59729:KDELR3
uniprot id: H0ZJG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:LOC105759110
gene id: 59729:LOC105759110
uniprot id: A0A674GLD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

59729:SLC25A6
gene id: 59729:SLC25A6
uniprot id: B5FYE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

59729:SAR1B
gene id: 59729:SAR1B
uniprot id: A0A674HIJ7
uniprot id: B5G3P5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Belongs to the small GTPase superfamily. SAR1 family.

59729:PPIH
gene id: 59729:PPIH
uniprot id: H1A3T3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:BBS5
gene id: 59729:BBS5
uniprot id: H0ZBX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBS5 family.
messages: Membrane
messages: Required for ciliogenesis.
messages: centriolar satellite
messages: cilium membrane

59729:EPS8
gene id: 59729:EPS8
uniprot id: A0A674H4H1
names: Similarity
messages: Belongs to the EPS8 family.

59729:ARL6IP5
gene id: 59729:ARL6IP5
uniprot id: H0ZHM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

59729:LYRM7
gene id: 59729:LYRM7
uniprot id: H0YQ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.
messages: Belongs to the complex I LYR family.
messages: Interacts with UQCRFS1.
messages: Mitochondrion matrix

59729:GOLM1
gene id: 59729:GOLM1
uniprot id: H0YXU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

59729:PDCD10
gene id: 59729:PDCD10
uniprot id: H0ZLF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

59729:SAP18
gene id: 59729:SAP18
uniprot id: B5G450
names: Function
names: Similarity
messages: Belongs to the SAP18 family.
messages: Involved in the tethering of the SIN3 complex to core histone proteins.

59729:NPM1
gene id: 59729:NPM1
uniprot id: B5G0J3
names: Similarity
messages: Belongs to the nucleoplasmin family.

59729:NFIA
gene id: 59729:NFIA
uniprot id: A0A674H003
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

59729:KEG28 p11
gene id: 59729:KEG28_p11
uniprot id: Q27GW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

59729:UTP11
gene id: 59729:UTP11
uniprot id: B5FZT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

59729:EVA1C
gene id: 59729:EVA1C
uniprot id: H0ZT96
names: Similarity
messages: Belongs to the EVA1 family.

59729:HSDL2
gene id: 59729:HSDL2
uniprot id: H0YSN7
names: Subcellular Location Annotation
messages: Peroxisome

59729:TMEM50B
gene id: 59729:TMEM50B
uniprot id: B5FYJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

59729:LEP
gene id: 59729:LEP
uniprot id: A0A023GUT0
names: Similarity
messages: Belongs to the leptin family.

59729:PDCD5
gene id: 59729:PDCD5
uniprot id: B5FZV5
names: Similarity
messages: Belongs to the PDCD5 family.

59729:CELF1
gene id: 59729:CELF1
uniprot id: A0A674GZ56
uniprot id: A0A674HQ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

59729:COPG1
gene id: 59729:COPG1
uniprot id: H0ZBU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

59729:TYR
gene id: 59729:TYR
uniprot id: H0ZRN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane
messages: Membrane

59729:NTS
gene id: 59729:NTS
uniprot id: B5G1S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurotensin family.
messages: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
messages: Secreted
messages: Vesicle
messages: secretory vesicle

59729:LOC100219720
gene id: 59729:LOC100219720
uniprot id: H0Z182
names: Similarity
messages: Belongs to the DNase I family.

59729:HOXD11
gene id: 59729:HOXD11
uniprot id: H0ZF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

59729:TRUB2
gene id: 59729:TRUB2
uniprot id: B5FZ44
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

59729:CYFIP1
gene id: 59729:CYFIP1
uniprot id: A0A674GP98
names: Similarity
messages: Belongs to the CYFIP family.

59729:CRHR1
gene id: 59729:CRHR1
uniprot id: A0A2D1CIG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

59729:LOC100225375
gene id: 59729:LOC100225375
uniprot id: H0ZG71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:DR1
gene id: 59729:DR1
uniprot id: H0Z693
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

59729:SEPTIN3
gene id: 59729:SEPTIN3
uniprot id: A0A674H815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm

59729:PLAGL2
gene id: 59729:PLAGL2
uniprot id: A0A674G710
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the krueppel C2H2-type zinc-finger protein family.
messages: Nucleus

59729:GRPR
gene id: 59729:GRPR
uniprot id: H0ZC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:PTCH1
gene id: 59729:PTCH1
uniprot id: H0YQK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

59729:RPS4X
gene id: 59729:RPS4X
uniprot id: B5FXF0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

59729:ING1
gene id: 59729:ING1
uniprot id: A0A674H5S7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

59729:MAP3K5
gene id: 59729:MAP3K5
uniprot id: H0ZKT1
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

59729:LOC100226496
gene id: 59729:LOC100226496
uniprot id: A0A674GCG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:SELENOS
gene id: 59729:SELENOS
uniprot id: B5FZK0
uniprot id: B5FZK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the selenoprotein S family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:MRPL47
gene id: 59729:MRPL47
uniprot id: B5FYD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Mitochondrion

59729:ASF1A
gene id: 59729:ASF1A
uniprot id: A0A674HJ14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

59729:CPSF4
gene id: 59729:CPSF4
uniprot id: H0ZB24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).
messages: Component of the cleavage and polyadenylation specificity factor (CPSF) complex.
messages: Nucleus

59729:ANKRD13A
gene id: 59729:ANKRD13A
uniprot id: H0ZAW2
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

59729:ARRDC3
gene id: 59729:ARRDC3
uniprot id: H0YR15
names: Similarity
messages: Belongs to the arrestin family.

59729:MRPS17
gene id: 59729:MRPS17
uniprot id: B5G022
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

59729:FERMT1
gene id: 59729:FERMT1
uniprot id: A0A674GWM6
names: Similarity
messages: Belongs to the kindlin family.

59729:MRPL20
gene id: 59729:MRPL20
uniprot id: B5G0D8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.

59729:MPC1
gene id: 59729:MPC1
uniprot id: B5FZS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

59729:KRT222
gene id: 59729:KRT222
uniprot id: H0YVW4
names: Similarity
messages: Belongs to the intermediate filament family.

59729:LPAR3
gene id: 59729:LPAR3
uniprot id: H0Z7Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:IL6ST
gene id: 59729:IL6ST
uniprot id: A0A674HAB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

59729:SOST
gene id: 59729:SOST
uniprot id: H0YXK3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the sclerostin family.
messages: Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

59729:UCK2
gene id: 59729:UCK2
uniprot id: B5FYF5
names: Similarity
names: Subunit
messages: Belongs to the uridine kinase family.
messages: Homotetramer.

59729:NDUFAB1
gene id: 59729:NDUFAB1
uniprot id: B5G0K6
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

59729:GOLT1B
gene id: 59729:GOLT1B
uniprot id: A0A674H7N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

59729:NQO2
gene id: 59729:NQO2
uniprot id: H0YVB6
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

59729:EVL
gene id: 59729:EVL
uniprot id: H0ZR82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ena/VASP family.
messages: lamellipodium
messages: stress fiber

59729:HAAO
gene id: 59729:HAAO
uniprot id: H0YZ81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

59729:CSNK1D
gene id: 59729:CSNK1D
uniprot id: A0A674HSS6
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:SSBP1
gene id: 59729:SSBP1
uniprot id: B5FZJ9
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

59729:MRPL32
gene id: 59729:MRPL32
uniprot id: B5G050
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

59729:LOC100190204
gene id: 59729:LOC100190204
uniprot id: B5FYW2
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

59729:UBE2D3
gene id: 59729:UBE2D3
uniprot id: A0A674GLN1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:RPS29
gene id: 59729:RPS29
uniprot id: B5FZD5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the 40S small ribosomal subunit.

59729:PIGH
gene id: 59729:PIGH
uniprot id: A0A674GX35
names: Similarity
messages: Belongs to the PIGH family.

59729:CASQ2
gene id: 59729:CASQ2
uniprot id: H0ZT41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

59729:CMTR1
gene id: 59729:CMTR1
uniprot id: H0ZC72
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).

59729:KIF11
gene id: 59729:KIF11
uniprot id: H0ZF48
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

59729:PSAT1
gene id: 59729:PSAT1
uniprot id: H0YYW7
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.

59729:BZW1
gene id: 59729:BZW1
uniprot id: H0ZJG2
names: Similarity
messages: Belongs to the BZW family.

59729:CERS4
gene id: 59729:CERS4
uniprot id: A0A674GKQ3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

59729:SLC16A3
gene id: 59729:SLC16A3
uniprot id: A0A674GM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

59729:ADI1
gene id: 59729:ADI1
uniprot id: H0ZRX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

59729:INIP
gene id: 59729:INIP
uniprot id: B5KFM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Belongs to the multiprotein complex Integrator. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP (By similarity).
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity).
messages: Nucleus

59729:LOC100220008
gene id: 59729:LOC100220008
uniprot id: H0Z5N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Membrane

59729:ATP6V0C
gene id: 59729:ATP6V0C
uniprot id: B5G238
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

59729:RAMP3
gene id: 59729:RAMP3
uniprot id: A0A674GA25
names: Similarity
messages: Belongs to the RAMP family.

59729:FAM162A
gene id: 59729:FAM162A
uniprot id: A0A674HMM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

59729:UBE2N
gene id: 59729:UBE2N
uniprot id: B5G4T1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:LOC100226706
gene id: 59729:LOC100226706
uniprot id: A0A674H9I1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:STAG2
gene id: 59729:STAG2
uniprot id: H0Z009
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCC3 family.
messages: Chromosome
messages: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
messages: Nucleus
messages: Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
messages: centromere

59729:GTF2E1
gene id: 59729:GTF2E1
uniprot id: A0A674H399
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

59729:RPL30
gene id: 59729:RPL30
uniprot id: B5FYY0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

59729:SH3GL2
gene id: 59729:SH3GL2
uniprot id: H0Z210
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

59729:GABRG3
gene id: 59729:GABRG3
uniprot id: A0A674HB18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

59729:HOXA9
gene id: 59729:HOXA9
uniprot id: H0YXI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

59729:AQP9
gene id: 59729:AQP9
uniprot id: H0Z6Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

59729:MED10
gene id: 59729:MED10
uniprot id: B5FYB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:LOC100231622
gene id: 59729:LOC100231622
uniprot id: A0A674GN47
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

59729:CA7
gene id: 59729:CA7
uniprot id: H0ZHF2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

59729:APOH
gene id: 59729:APOH
uniprot id: H0Z1D4
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:SWS2
gene id: 59729:SWS2
uniprot id: Q9IA34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

59729:MDH1
gene id: 59729:MDH1
uniprot id: B5G179
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

59729:LOC100189947
gene id: 59729:LOC100189947
uniprot id: B5FX61
names: Similarity
messages: Belongs to the BTG family.

59729:RPL32
gene id: 59729:RPL32
uniprot id: B5G0L6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

59729:RAB21
gene id: 59729:RAB21
uniprot id: H0ZA75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Cytoplasmic vesicle membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: neuron projection
messages: trans-Golgi network

59729:CDC42
gene id: 59729:CDC42
uniprot id: A0A674HL77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Membrane
messages: Midbody
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

59729:IGF1R
gene id: 59729:IGF1R
uniprot id: H0ZEE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

59729:RBX1
gene id: 59729:RBX1
uniprot id: B5FY05
names: Similarity
messages: Belongs to the RING-box family.

59729:UGP2
gene id: 59729:UGP2
uniprot id: H0YVL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

59729:IGF2BP3
gene id: 59729:IGF2BP3
uniprot id: H0YX46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM IMP/VICKZ family.
messages: Cytoplasm
messages: Nucleus

59729:RBP1
gene id: 59729:RBP1
uniprot id: H0Z405
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:HMGA2
gene id: 59729:HMGA2
uniprot id: A0A674HW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

59729:KCNA1
gene id: 59729:KCNA1
uniprot id: A0A674GWK0
names: Subcellular Location Annotation
messages: Membrane

59729:RPL38
gene id: 59729:RPL38
uniprot id: B5FYZ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

59729:PSENEN
gene id: 59729:PSENEN
uniprot id: B5KFN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

59729:CRHR2
gene id: 59729:CRHR2
uniprot id: A0A674H3I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

59729:NPY2R
gene id: 59729:NPY2R
uniprot id: A0A674GEW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:PLA2G12A
gene id: 59729:PLA2G12A
uniprot id: H0Z147
names: Subcellular Location Annotation
messages: Secreted

59729:TADA1
gene id: 59729:TADA1
uniprot id: A0A674GC23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TADA1 family.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

59729:MYOD1
gene id: 59729:MYOD1
uniprot id: H0ZER5
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Nucleus

59729:CNIH1
gene id: 59729:CNIH1
uniprot id: B5FX71
uniprot id: H0ZS87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

59729:SYNGR1
gene id: 59729:SYNGR1
uniprot id: A0A674H9K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

59729:KEG28 p08
gene id: 59729:KEG28_p08
uniprot id: Q27GW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

59729:ALG2
gene id: 59729:ALG2
uniprot id: B5FYC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
messages: Membrane

59729:LOC100222345
gene id: 59729:LOC100222345
uniprot id: H0YTH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

59729:RPS17
gene id: 59729:RPS17
uniprot id: B5FYG2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

59729:LOC100190507
gene id: 59729:LOC100190507
uniprot id: B5G401
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

59729:RRAGC
gene id: 59729:RRAGC
uniprot id: A0A674GKM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

59729:AP2B1
gene id: 59729:AP2B1
uniprot id: A0A674HTC3
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

59729:DERL3
gene id: 59729:DERL3
uniprot id: B5FZE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

59729:LOC100231862
gene id: 59729:LOC100231862
uniprot id: H0ZDW2
names: Similarity
messages: Belongs to the cytochrome P450 family.

59729:CDC34
gene id: 59729:CDC34
uniprot id: H0YQR3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:FAM126A
gene id: 59729:FAM126A
uniprot id: A0A674GY84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM126 family.
messages: Cell membrane
messages: Membrane
messages: cytosol

59729:IGF1
gene id: 59729:IGF1
uniprot id: A0A674GWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

59729:LAMTOR3
gene id: 59729:LAMTOR3
uniprot id: B5G0H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

59729:SLC25A21
gene id: 59729:SLC25A21
uniprot id: H0ZP51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:GPR161
gene id: 59729:GPR161
uniprot id: H0ZT89
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:CEP43
gene id: 59729:CEP43
uniprot id: A0A674GU77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: cilium basal body

59729:DKK2
gene id: 59729:DKK2
uniprot id: A0A674GPV1
names: Similarity
messages: Belongs to the dickkopf family.

59729:POLR2D
gene id: 59729:POLR2D
uniprot id: B5FZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

59729:CREBL2
gene id: 59729:CREBL2
uniprot id: B5G0C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

59729:KPNA5
gene id: 59729:KPNA5
uniprot id: H0ZNW0
names: Similarity
messages: Belongs to the importin alpha family.

59729:WIF1
gene id: 59729:WIF1
uniprot id: H0Z857
names: Caution
names: Function
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:TSPO
gene id: 59729:TSPO
uniprot id: H0ZP63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

59729:SCNN1A
gene id: 59729:SCNN1A
uniprot id: H0ZSY8
names: Subcellular Location Annotation
messages: Membrane

59729:NDUFS4
gene id: 59729:NDUFS4
uniprot id: B5FZK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mitochondrion inner membrane

59729:SNRPA1
gene id: 59729:SNRPA1
uniprot id: B5FXA8
uniprot id: H0ZF70
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

59729:NPY4R2
gene id: 59729:NPY4R2
uniprot id: H0ZC49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:SNRPD3
gene id: 59729:SNRPD3
uniprot id: B5G3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

59729:ADRM1
gene id: 59729:ADRM1
uniprot id: B5G2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

59729:ARRDC2
gene id: 59729:ARRDC2
uniprot id: H0YQ68
names: Similarity
messages: Belongs to the arrestin family.

59729:PGM1
gene id: 59729:PGM1
uniprot id: H0ZI36
names: Similarity
messages: Belongs to the phosphohexose mutase family.

59729:TOM1L2
gene id: 59729:TOM1L2
uniprot id: A0A674HRP7
uniprot id: H0ZAC1
names: Similarity
messages: Belongs to the TOM1 family.

59729:FGF13
gene id: 59729:FGF13
uniprot id: A0A674GKU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: dendrite
messages: filopodium
messages: growth cone
messages: sarcolemma

59729:DNASE2B
gene id: 59729:DNASE2B
uniprot id: H0Z889
names: Similarity
messages: Belongs to the DNase II family.

59729:MPG
gene id: 59729:MPG
uniprot id: H0Z1V7
names: Function
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.
messages: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

59729:NPSR1
gene id: 59729:NPSR1
uniprot id: H0Z4J9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:PRDX1
gene id: 59729:PRDX1
uniprot id: B5G0L9
uniprot id: B5G0N0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

59729:LOC100226305
gene id: 59729:LOC100226305
uniprot id: B5FYW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:VPS26C
gene id: 59729:VPS26C
uniprot id: A0A674HU40
names: Similarity
messages: Belongs to the VPS26 family.

59729:IMPDH2
gene id: 59729:IMPDH2
uniprot id: H0ZFC1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

59729:TAF1
gene id: 59729:TAF1
uniprot id: A0A674GS99
uniprot id: H0Z9H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF1 family.
messages: Nucleus

59729:BLOC1S5
gene id: 59729:BLOC1S5
uniprot id: A0A674GQ93
names: Function
names: Similarity
messages: Belongs to the BLOC1S5 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).

59729:TMEM35A
gene id: 59729:TMEM35A
uniprot id: A0A674GZM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane
messages: Vesicle

59729:PTGES3L
gene id: 59729:PTGES3L
uniprot id: B5G0B0
names: Similarity
messages: Belongs to the p23/wos2 family.

59729:MMUT
gene id: 59729:MMUT
uniprot id: A0A674H6C5
names: Function
names: Similarity
messages: Belongs to the methylmalonyl-CoA mutase family.
messages: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.

59729:BTF3L4
gene id: 59729:BTF3L4
uniprot id: A0A674GHC7
uniprot id: B5FX99
names: Similarity
messages: Belongs to the NAC-beta family.

59729:CSRNP1
gene id: 59729:CSRNP1
uniprot id: A0A674HNM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

59729:STARD13
gene id: 59729:STARD13
uniprot id: A0A674GYF5
names: Subcellular Location Annotation
messages: Cytoplasm

59729:SLC44A1
gene id: 59729:SLC44A1
uniprot id: A0A674H469
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

59729:DUT
gene id: 59729:DUT
uniprot id: B5FY95
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

59729:RPL27A
gene id: 59729:RPL27A
uniprot id: B5G0Y3
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

59729:UTP25
gene id: 59729:UTP25
uniprot id: H0YYG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

59729:PHACTR2
gene id: 59729:PHACTR2
uniprot id: A0A674HBW7
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

59729:HMX2
gene id: 59729:HMX2
uniprot id: H0ZMA3
names: Subcellular Location Annotation
messages: Nucleus

59729:SEC61B
gene id: 59729:SEC61B
uniprot id: B5FZ77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

59729:H3F3A
gene id: 59729:H3F3A
uniprot id: B5FZ57
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:ST6GALNAC1
gene id: 59729:ST6GALNAC1
uniprot id: H0ZBX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

59729:ALAS1
gene id: 59729:ALAS1
uniprot id: H0Z6Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion inner membrane

59729:SDHD
gene id: 59729:SDHD
uniprot id: B5FZ35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

59729:PICK1
gene id: 59729:PICK1
uniprot id: A0A674HR02
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

59729:CCT5
gene id: 59729:CCT5
uniprot id: A0A674HGJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

59729:CIAO2A
gene id: 59729:CIAO2A
uniprot id: B5FXS7
names: Similarity
messages: Belongs to the MIP18 family.

59729:GPRC6A
gene id: 59729:GPRC6A
uniprot id: H0ZNV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

59729:LYPLA1
gene id: 59729:LYPLA1
uniprot id: A0A674HNX0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

59729:RPF1
gene id: 59729:RPF1
uniprot id: H0Z878
names: Subcellular Location Annotation
messages: nucleolus

59729:CCKAR
gene id: 59729:CCKAR
uniprot id: H0ZG11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

59729:NACC2
gene id: 59729:NACC2
uniprot id: A0A674GS50
names: Subcellular Location Annotation
messages: Nucleus

59729:XPO1
gene id: 59729:XPO1
uniprot id: H0Z824
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

59729:PLA2R1
gene id: 59729:PLA2R1
uniprot id: H0Z879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Membrane

59729:MSANTD3
gene id: 59729:MSANTD3
uniprot id: H0ZEJ6
names: Similarity
messages: Belongs to the MSANTD3 family.

59729:RPL21
gene id: 59729:RPL21
uniprot id: B5FY47
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

59729:WNT5A
gene id: 59729:WNT5A
uniprot id: H0Z9G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

59729:SLC2A13
gene id: 59729:SLC2A13
uniprot id: A0A674HAZ7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

59729:SCTR
gene id: 59729:SCTR
uniprot id: H0ZMS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

59729:LOC100190109
gene id: 59729:LOC100190109
uniprot id: B5FY56
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

59729:PYCR3
gene id: 59729:PYCR3
uniprot id: B5G1C0
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

59729:BET1
gene id: 59729:BET1
uniprot id: A0A674H1G8
names: Subcellular Location Annotation
messages: Membrane

59729:TMEM251
gene id: 59729:TMEM251
uniprot id: A0A674GAG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM251 family.
messages: Membrane

59729:IFT20
gene id: 59729:IFT20
uniprot id: B5G0K2
names: Subcellular Location Annotation
messages: centriole
messages: cilium
messages: cis-Golgi network

59729:POLR2F
gene id: 59729:POLR2F
uniprot id: B5G123
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.
messages: Nucleus

59729:NAA35
gene id: 59729:NAA35
uniprot id: A0A674HHI3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

59729:KEG28 p13
gene id: 59729:KEG28_p13
uniprot id: Q27GW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Membrane
messages: Mitochondrion inner membrane

59729:SCOC
gene id: 59729:SCOC
uniprot id: A0A674HBG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

59729:CPOX
gene id: 59729:CPOX
uniprot id: H0ZT91
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

59729:SNRPB
gene id: 59729:SNRPB
uniprot id: B5G4G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

59729:ARF6
gene id: 59729:ARF6
uniprot id: B5G0L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Cell membrane
messages: Cleavage furrow
messages: Endosome membrane
messages: Midbody ring
messages: Recycling endosome membrane
messages: filopodium membrane
messages: ruffle

59729:PDIK1L
gene id: 59729:PDIK1L
uniprot id: A0A674GU31
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:CRYBB1
gene id: 59729:CRYBB1
uniprot id: H0ZBN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.
messages: Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.

59729:RPL23A
gene id: 59729:RPL23A
uniprot id: B5FZ39
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

59729:CDK3
gene id: 59729:CDK3
uniprot id: H0ZCU2
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:CSF1R
gene id: 59729:CSF1R
uniprot id: D8UWE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Membrane

59729:LOC100220191
gene id: 59729:LOC100220191
uniprot id: H0ZSJ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

59729:CHD6
gene id: 59729:CHD6
uniprot id: H0YYE6
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

59729:CPLX1
gene id: 59729:CPLX1
uniprot id: B5FXE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

59729:SLC6A20
gene id: 59729:SLC6A20
uniprot id: H0Z406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

59729:LOC100229913
gene id: 59729:LOC100229913
uniprot id: H0Z677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Nucleus

59729:CYRIA
gene id: 59729:CYRIA
uniprot id: A0A674GPW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYRI family.
messages: Membrane

59729:RAB3IL1
gene id: 59729:RAB3IL1
uniprot id: A0A674GCR5
uniprot id: A0A674HP77
names: Similarity
messages: Belongs to the SEC2 family.

59729:LYRM4
gene id: 59729:LYRM4
uniprot id: B5FZA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion
messages: Nucleus
messages: Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.

59729:ATP5MC3
gene id: 59729:ATP5MC3
uniprot id: H0ZF13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

59729:MRPS16
gene id: 59729:MRPS16
uniprot id: B5FXE4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

59729:UNC50
gene id: 59729:UNC50
uniprot id: H0ZIU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

59729:RPS19
gene id: 59729:RPS19
uniprot id: B5FYU1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

59729:MED9
gene id: 59729:MED9
uniprot id: B5G4A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:LOC751995
gene id: 59729:LOC751995
uniprot id: H0Z779
names: Subcellular Location Annotation
messages: Nucleus

59729:YBEY
gene id: 59729:YBEY
uniprot id: H0YZ61
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

59729:NLGN4X
gene id: 59729:NLGN4X
uniprot id: A0A674GJB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

59729:CPEB4
gene id: 59729:CPEB4
uniprot id: A0A674HDZ1
uniprot id: H0YPY7
names: Similarity
messages: Belongs to the RRM CPEB family.

59729:LRP12
gene id: 59729:LRP12
uniprot id: H0ZPL9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:MRPL22
gene id: 59729:MRPL22
uniprot id: B5FXB1
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

59729:CKB
gene id: 59729:CKB
uniprot id: B5G2T1
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

59729:GPATCH11
gene id: 59729:GPATCH11
uniprot id: H0ZEN2
names: Similarity
messages: Belongs to the GPATCH11 family.

59729:TDO2
gene id: 59729:TDO2
uniprot id: H0Z4T4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer. Dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:MEOX1
gene id: 59729:MEOX1
uniprot id: H0YXK2
names: Subcellular Location Annotation
messages: Nucleus

59729:BCAS2
gene id: 59729:BCAS2
uniprot id: B5G466
uniprot id: B5G470
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPF27 family.
messages: Nucleus

59729:ATP5MF
gene id: 59729:ATP5MF
uniprot id: B5FY90
names: Function
names: Similarity
messages: Belongs to the ATPase F chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

59729:PACSIN2
gene id: 59729:PACSIN2
uniprot id: A0A674HKS7
uniprot id: A0A674HP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

59729:NDUFS6
gene id: 59729:NDUFS6
uniprot id: B5FZT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

59729:MYADML2
gene id: 59729:MYADML2
uniprot id: A0A674GXV4
names: Subcellular Location Annotation
messages: Membrane

59729:EIF2S1
gene id: 59729:EIF2S1
uniprot id: B5FYU5
uniprot id: H0ZMS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

59729:MC1R
gene id: 59729:MC1R
uniprot id: H0ZCF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

59729:TAAR1
gene id: 59729:TAAR1
uniprot id: H0ZMX8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:LTV1
gene id: 59729:LTV1
uniprot id: A0A674H4M8
names: Similarity
messages: Belongs to the LTV1 family.

59729:SF3B1
gene id: 59729:SF3B1
uniprot id: A0A674GB95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

59729:LOC105759120
gene id: 59729:LOC105759120
uniprot id: H1A4M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

59729:KCNA10
gene id: 59729:KCNA10
uniprot id: H0YRH1
names: Subcellular Location Annotation
messages: Membrane

59729:TPRA1
gene id: 59729:TPRA1
uniprot id: A0A674H332
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0359 family.
messages: Membrane

59729:RPL37
gene id: 59729:RPL37
uniprot id: Q563Y1
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

59729:KYAT3
gene id: 59729:KYAT3
uniprot id: H0Z768
names: Subunit
messages: Homodimer.

59729:PARN
gene id: 59729:PARN
uniprot id: H0Z3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Cytoplasm
messages: Nucleus

59729:NT5C2
gene id: 59729:NT5C2
uniprot id: A0A674GKN4
names: Cofactor
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Binds 1 Mg(2+) ion per subunit.

59729:TUSC3
gene id: 59729:TUSC3
uniprot id: B5G2V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:FUNDC1
gene id: 59729:FUNDC1
uniprot id: H0Z6V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FUN14 family.
messages: Mitochondrion outer membrane

59729:ROMO1
gene id: 59729:ROMO1
uniprot id: B5G4G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

59729:MRPS6
gene id: 59729:MRPS6
uniprot id: B5FYX3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

59729:TIMM21
gene id: 59729:TIMM21
uniprot id: A0A674HQG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion membrane

59729:OCIAD1
gene id: 59729:OCIAD1
uniprot id: B5G016
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OCIAD1 family.
messages: Endosome
messages: Interacts with STAT3.
messages: Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.
messages: The OCIA domain is necessary and sufficient for endosomal localization.

59729:PHKB
gene id: 59729:PHKB
uniprot id: A0A674HQQ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

59729:PTPA
gene id: 59729:PTPA
uniprot id: A0A674HRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:TPM2
gene id: 59729:TPM2
uniprot id: B5FZA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

59729:ADCYAP1
gene id: 59729:ADCYAP1
uniprot id: A0A674GJE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

59729:NEIL2
gene id: 59729:NEIL2
uniprot id: H0ZSU3
names: Similarity
messages: Belongs to the FPG family.

59729:CLN8
gene id: 59729:CLN8
uniprot id: A0A674G832
names: Subcellular Location Annotation
messages: Membrane

59729:MRPL28
gene id: 59729:MRPL28
uniprot id: B5G132
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

59729:LOC100218088
gene id: 59729:LOC100218088
uniprot id: H0ZAM6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

59729:AKIRIN2
gene id: 59729:AKIRIN2
uniprot id: B5FXF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

59729:DGCR6L
gene id: 59729:DGCR6L
uniprot id: B5KFS0
names: Similarity
messages: Belongs to the gonadal family.

59729:SNX9
gene id: 59729:SNX9
uniprot id: H0ZLH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

59729:LOC105758847
gene id: 59729:LOC105758847
uniprot id: A0A674H6Y7
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:NCALD
gene id: 59729:NCALD
uniprot id: P62759
names: Function
names: Similarity
messages: Belongs to the recoverin family.
messages: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity).

59729:ACAA1
gene id: 59729:ACAA1
uniprot id: H0YQ62
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

59729:CD38
gene id: 59729:CD38
uniprot id: H0ZHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-ribosyl cyclase family.
messages: Membrane

59729:HOXC9
gene id: 59729:HOXC9
uniprot id: H0ZVN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

59729:PPP2R5E
gene id: 59729:PPP2R5E
uniprot id: A0A674HKN2
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

59729:SLC13A3
gene id: 59729:SLC13A3
uniprot id: H0Z4Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

59729:POLR3H
gene id: 59729:POLR3H
uniprot id: H0ZHZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Nucleus

59729:XRCC3
gene id: 59729:XRCC3
uniprot id: H0ZRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

59729:ATP6V1E1
gene id: 59729:ATP6V1E1
uniprot id: B5FXT2
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

59729:CSNK2A2
gene id: 59729:CSNK2A2
uniprot id: A0A674HFG3
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:SMU1
gene id: 59729:SMU1
uniprot id: H0YT94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SMU1 family.
messages: Nucleus speckle

59729:GANC
gene id: 59729:GANC
uniprot id: H0ZLE6
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

59729:BRD1
gene id: 59729:BRD1
uniprot id: A0A674HL82
names: Subcellular Location Annotation
messages: Nucleus

59729:KEG28 p04
gene id: 59729:KEG28_p04
uniprot id: Q27GV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion membrane

59729:LOC100190429
gene id: 59729:LOC100190429
uniprot id: B5G208
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

59729:ATP2A2
gene id: 59729:ATP2A2
uniprot id: H0Z5X4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

59729:MOCS2
gene id: 59729:MOCS2
uniprot id: B5FXU9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).
messages: cytosol

59729:LOC100227529
gene id: 59729:LOC100227529
uniprot id: H0ZT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine gamma family.
messages: Secreted

59729:SLC25A17
gene id: 59729:SLC25A17
uniprot id: H0ZII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:HPGD
gene id: 59729:HPGD
uniprot id: H0Z7D9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

59729:MESD
gene id: 59729:MESD
uniprot id: A0A674GHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MESD family.
messages: Endoplasmic reticulum

59729:MID1IP1
gene id: 59729:MID1IP1
uniprot id: B5FZW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPOT14 family.
messages: Cytoplasm
messages: Nucleus

59729:LOC100221351
gene id: 59729:LOC100221351
uniprot id: A0A674HTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

59729:PLCB1
gene id: 59729:PLCB1
uniprot id: A0A674GHY6
uniprot id: A0A674GJH3
names: Function
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

59729:RPS14
gene id: 59729:RPS14
uniprot id: B5G2V9
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

59729:MMAB
gene id: 59729:MMAB
uniprot id: B5FZU3
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

59729:SYF2
gene id: 59729:SYF2
uniprot id: B5FYV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

59729:NFRKB
gene id: 59729:NFRKB
uniprot id: A0A674GWM7
uniprot id: A0A674HHU0
names: Subcellular Location Annotation
messages: Nucleus

59729:BBLN
gene id: 59729:BBLN
uniprot id: B5FY93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0184 (EST00098) family.
messages: Cell junction
messages: Essential for intermediate filament organization in intestinal cells, interacts with intermediate filament and regulates intestinal lumen morphology.
messages: cytoskeleton

59729:ST6GALNAC3
gene id: 59729:ST6GALNAC3
uniprot id: A0A674GPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

59729:NDUFAF1
gene id: 59729:NDUFAF1
uniprot id: B5FXZ3
names: Function
names: Similarity
messages: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.
messages: Belongs to the CIA30 family.

59729:NCAPG
gene id: 59729:NCAPG
uniprot id: A0A674H9G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

59729:NR1H4
gene id: 59729:NR1H4
uniprot id: H0ZFA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
messages: Nucleus

59729:HTR1D
gene id: 59729:HTR1D
uniprot id: H0YT67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:ATP6V0D2
gene id: 59729:ATP6V0D2
uniprot id: H0ZNC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

59729:RAN
gene id: 59729:RAN
uniprot id: B5FYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

59729:N6AMT1
gene id: 59729:N6AMT1
uniprot id: A0A674H854
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

59729:PSMB1
gene id: 59729:PSMB1
uniprot id: B5G4R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

59729:LIN28B
gene id: 59729:LIN28B
uniprot id: A0A674GMH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-28 family.
messages: nucleolus

59729:IMPA1
gene id: 59729:IMPA1
uniprot id: H0ZN52
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

59729:SIAH1
gene id: 59729:SIAH1
uniprot id: H0ZEA6
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

59729:LOC100231060
gene id: 59729:LOC100231060
uniprot id: H0ZGA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:FGF7
gene id: 59729:FGF7
uniprot id: A0A674GAG8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

59729:FABP5
gene id: 59729:FABP5
uniprot id: B5FXG2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:SOX14
gene id: 59729:SOX14
uniprot id: H0Z8W5
names: Subcellular Location Annotation
messages: Nucleus

59729:MED27
gene id: 59729:MED27
uniprot id: B5FXG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 27 family.
messages: Nucleus

59729:ARHGDIG
gene id: 59729:ARHGDIG
uniprot id: B5G151
names: Similarity
messages: Belongs to the Rho GDI family.

59729:CCNK
gene id: 59729:CCNK
uniprot id: H0ZR50
names: Similarity
messages: Belongs to the cyclin family.

59729:POLR3F
gene id: 59729:POLR3F
uniprot id: H0Z623
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

59729:MIX23
gene id: 59729:MIX23
uniprot id: B5FX56
names: Similarity
messages: Belongs to the MIX23 family.

59729:CHRDL2
gene id: 59729:CHRDL2
uniprot id: H0ZTA5
names: Subcellular Location Annotation
messages: Secreted

59729:ABHD2
gene id: 59729:ABHD2
uniprot id: H0ZD64
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

59729:PCNA
gene id: 59729:PCNA
uniprot id: B5KFN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

59729:ATPAF1
gene id: 59729:ATPAF1
uniprot id: B5FZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

59729:DPM1
gene id: 59729:DPM1
uniprot id: B5FZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.

59729:ECHS1
gene id: 59729:ECHS1
uniprot id: B5FXI3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

59729:PDSS2
gene id: 59729:PDSS2
uniprot id: A0A674GF37
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

59729:PIK3R1
gene id: 59729:PIK3R1
uniprot id: A0A674GQ40
uniprot id: H0YXT8
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

59729:SLC35B1
gene id: 59729:SLC35B1
uniprot id: B5FZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

59729:GMPR
gene id: 59729:GMPR
uniprot id: A0A674HNY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

59729:STAT1
gene id: 59729:STAT1
uniprot id: H0ZKL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

59729:NDUFA8
gene id: 59729:NDUFA8
uniprot id: B5FYB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Mitochondrion intermembrane space

59729:MED17
gene id: 59729:MED17
uniprot id: H0ZRI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:H3F3B
gene id: 59729:H3F3B
uniprot id: B5FZ57
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:HSBP1
gene id: 59729:HSBP1
uniprot id: B5G3X1
names: Similarity
messages: Belongs to the HSBP1 family.

59729:RGR
gene id: 59729:RGR
uniprot id: H0Z6G8
names: Subcellular Location Annotation
messages: Membrane

59729:MAFF
gene id: 59729:MAFF
uniprot id: A0A674HER0
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

59729:MED7
gene id: 59729:MED7
uniprot id: B5FX93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

59729:ACVR2B
gene id: 59729:ACVR2B
uniprot id: H0YQK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

59729:AHSA2P
gene id: 59729:AHSA2P
uniprot id: B5FYC5
names: Similarity
messages: Belongs to the AHA1 family.

59729:LOC100190442
gene id: 59729:LOC100190442
uniprot id: B5G297
names: Subcellular Location Annotation
messages: Secreted

59729:FAM32A
gene id: 59729:FAM32A
uniprot id: B5G3E9
names: Similarity
messages: Belongs to the FAM32 family.

59729:LOC100221480
gene id: 59729:LOC100221480
uniprot id: H0ZG86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:OGN
gene id: 59729:OGN
uniprot id: A0A674GB69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
messages: Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
messages: extracellular matrix

59729:TRAPPC2
gene id: 59729:TRAPPC2
uniprot id: B5KFM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

59729:LOC100228523
gene id: 59729:LOC100228523
uniprot id: B5G1T5
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

59729:CD40LG
gene id: 59729:CD40LG
uniprot id: H0YV53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
messages: Belongs to the tumor necrosis factor family.
messages: Cell surface

59729:RPLP1
gene id: 59729:RPLP1
uniprot id: B5FYY2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

59729:MFAP3
gene id: 59729:MFAP3
uniprot id: A0A674HJ65
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

59729:FGFBP2
gene id: 59729:FGFBP2
uniprot id: H0ZHK0
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

59729:COPB1
gene id: 59729:COPB1
uniprot id: A0A674GIG4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

59729:LOC100227127
gene id: 59729:LOC100227127
uniprot id: H0YUS5
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:PGLS
gene id: 59729:PGLS
uniprot id: B5FXQ4
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

59729:POP5
gene id: 59729:POP5
uniprot id: A0A674HMU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

59729:KEG28 p10
gene id: 59729:KEG28_p10
uniprot id: Q27GW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

59729:PAQR3
gene id: 59729:PAQR3
uniprot id: H0YTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

59729:QRFP
gene id: 59729:QRFP
uniprot id: F5HPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

59729:BRMS1L
gene id: 59729:BRMS1L
uniprot id: H0ZP36
names: Subcellular Location Annotation
messages: Nucleus

59729:LOC100224417
gene id: 59729:LOC100224417
uniprot id: H0ZG44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:UBLCP1
gene id: 59729:UBLCP1
uniprot id: H0YQN3
names: Function
names: Subcellular Location Annotation
messages: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
messages: Nucleus

59729:CCN4
gene id: 59729:CCN4
uniprot id: H0ZQQ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:ALYREF
gene id: 59729:ALYREF
uniprot id: B5FXN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
messages: Belongs to the ALYREF family.
messages: Cytoplasm
messages: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability (By similarity).
messages: Homomultimer. Is part of several complexes involved in mRNA processing and export. Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have a dynamic structure involving ATP-dependent remodeling (By similarity).
messages: Nucleus
messages: Nucleus speckle

59729:OPRL1
gene id: 59729:OPRL1
uniprot id: A0A674H9F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

59729:PIP4P2
gene id: 59729:PIP4P2
uniprot id: H0ZNL6
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

59729:SPC25
gene id: 59729:SPC25
uniprot id: A0A674H6M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

59729:LOC100224677
gene id: 59729:LOC100224677
uniprot id: H0Z0M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Membrane raft
messages: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

59729:TMEM50A
gene id: 59729:TMEM50A
uniprot id: B5G2J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

59729:RAD52
gene id: 59729:RAD52
uniprot id: H0ZQU2
names: Similarity
messages: Belongs to the RAD52 family.

59729:PGM3
gene id: 59729:PGM3
uniprot id: H0ZQN0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

59729:ST6GAL1
gene id: 59729:ST6GAL1
uniprot id: E4ZFH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

59729:LOC100227107
gene id: 59729:LOC100227107
uniprot id: H0ZE52
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.

59729:EEF1A2
gene id: 59729:EEF1A2
uniprot id: H0ZAP0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

59729:RARB
gene id: 59729:RARB
uniprot id: A0A674GGN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

59729:CAPZB
gene id: 59729:CAPZB
uniprot id: B5G462
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

59729:UBALD1
gene id: 59729:UBALD1
uniprot id: H0Z100
names: Similarity
messages: Belongs to the UBALD family.

59729:SPCS1
gene id: 59729:SPCS1
uniprot id: B5KFM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:BCLAF1
gene id: 59729:BCLAF1
uniprot id: A0A674HFV1
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

59729:UFM1
gene id: 59729:UFM1
uniprot id: A0A674H1L9
names: Similarity
messages: Belongs to the UFM1 family.

59729:TGFB2
gene id: 59729:TGFB2
uniprot id: H0YX95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

59729:SPIN1
gene id: 59729:SPIN1
uniprot id: H0YQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPIN/STSY family.
messages: Nucleus

59729:GPN1
gene id: 59729:GPN1
uniprot id: H0ZWK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

59729:UGDH
gene id: 59729:UGDH
uniprot id: H0ZET5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

59729:HDAC2
gene id: 59729:HDAC2
uniprot id: A0A674GYU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

59729:PPIL2
gene id: 59729:PPIL2
uniprot id: H0ZE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: Nucleus

59729:RARRES2
gene id: 59729:RARRES2
uniprot id: B5FX76
names: Subcellular Location Annotation
messages: Secreted

59729:CD28
gene id: 59729:CD28
uniprot id: H1A2C2
names: Subcellular Location Annotation
messages: Membrane

59729:ATG13
gene id: 59729:ATG13
uniprot id: A0A674GWT6
uniprot id: A0A674HI18
uniprot id: H0ZK35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

59729:B3GNT4
gene id: 59729:B3GNT4
uniprot id: H0Z6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

59729:EEF2K
gene id: 59729:EEF2K
uniprot id: A0A674GAV1
uniprot id: A0A674GPZ9
uniprot id: A0A674HKW0
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Alpha-type protein kinase family.
messages: Monomer or homodimer.
messages: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent.

59729:H2AFV
gene id: 59729:H2AFV
uniprot id: B5G0I6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:CEBPA
gene id: 59729:CEBPA
uniprot id: H0ZGP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

59729:GNAL
gene id: 59729:GNAL
uniprot id: A0A674GS32
names: Similarity
messages: Belongs to the G-alpha family. G(s) subfamily.

59729:RPS3
gene id: 59729:RPS3
uniprot id: B5FZR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: nucleolus
messages: spindle

59729:SEC11A
gene id: 59729:SEC11A
uniprot id: B5G294
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:OPTN
gene id: 59729:OPTN
uniprot id: A0A674GG47
uniprot id: A0A674GM34
names: Function
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Endosome
messages: Golgi apparatus
messages: May act by regulating membrane trafficking and cellular morphogenesis.
messages: Recycling endosome
messages: Vesicle
messages: autophagosome
messages: perinuclear region
messages: trans-Golgi network

59729:TAGLN3
gene id: 59729:TAGLN3
uniprot id: B5FZX6
uniprot id: B5FZX7
names: Similarity
messages: Belongs to the calponin family.

59729:COX6C
gene id: 59729:COX6C
uniprot id: B5FZE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6c family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

59729:BMP5
gene id: 59729:BMP5
uniprot id: H0ZRG8
names: Similarity
messages: Belongs to the TGF-beta family.

59729:ORC6
gene id: 59729:ORC6
uniprot id: B5G1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

59729:DDO
gene id: 59729:DDO
uniprot id: H0ZP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

59729:SEC11C
gene id: 59729:SEC11C
uniprot id: B5FZU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:ATF4
gene id: 59729:ATF4
uniprot id: B5G2X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

59729:ZFPM2
gene id: 59729:ZFPM2
uniprot id: A0A674HC26
names: Subcellular Location Annotation
messages: Nucleus

59729:SFT2D1
gene id: 59729:SFT2D1
uniprot id: B5FY39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

59729:VSNL1
gene id: 59729:VSNL1
uniprot id: B5G0J4
uniprot id: B5G0J7
names: Function
messages: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.

59729:LOC100232209
gene id: 59729:LOC100232209
uniprot id: H0ZG86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:NPVF
gene id: 59729:NPVF
uniprot id: D3KX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FARP (FMRFamide related peptide) family.
messages: Secreted

59729:RPS16
gene id: 59729:RPS16
uniprot id: B5FXQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

59729:MMD
gene id: 59729:MMD
uniprot id: H0ZGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

59729:ZADH2
gene id: 59729:ZADH2
uniprot id: A0A674HAV8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

59729:GOLM2
gene id: 59729:GOLM2
uniprot id: H0ZI19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

59729:ACO2
gene id: 59729:ACO2
uniprot id: H0ZI30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

59729:GHITM
gene id: 59729:GHITM
uniprot id: B5G2G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

59729:CRYAB
gene id: 59729:CRYAB
uniprot id: H0YPX8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

59729:SF3B5
gene id: 59729:SF3B5
uniprot id: H0ZKL9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SF3B5 family.
messages: Component of the spliceosome B complex.
messages: Nucleus

59729:FMC1
gene id: 59729:FMC1
uniprot id: B5FXE7
names: Similarity
messages: Belongs to the FMC1 family.

59729:SF3B6
gene id: 59729:SF3B6
uniprot id: A0A674GDV7
names: Subcellular Location Annotation
messages: Nucleus

59729:CIRBP
gene id: 59729:CIRBP
uniprot id: B5G1F8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm

59729:GRB10
gene id: 59729:GRB10
uniprot id: H0ZCA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

59729:PSME3IP1
gene id: 59729:PSME3IP1
uniprot id: B5G2E8
names: Subcellular Location Annotation
messages: Nucleus

59729:JAGN1
gene id: 59729:JAGN1
uniprot id: B5G4P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:KCNJ8
gene id: 59729:KCNJ8
uniprot id: A0A674H7X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

59729:NAIF1
gene id: 59729:NAIF1
uniprot id: H0YZ97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAIF1 family.
messages: Induces apoptosis.
messages: Nucleus

59729:ATP6V1C2
gene id: 59729:ATP6V1C2
uniprot id: H0ZS48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

59729:DPT
gene id: 59729:DPT
uniprot id: A0A674HDF4
names: Similarity
messages: Belongs to the dermatopontin family.

59729:GNB1
gene id: 59729:GNB1
uniprot id: H0YXS3
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

59729:RNF2
gene id: 59729:RNF2
uniprot id: H0YZZ3
names: Subcellular Location Annotation
messages: Chromosome
messages: Cytoplasm

59729:ACYP1
gene id: 59729:ACYP1
uniprot id: B5G0Y5
uniprot id: B5G0Y6
names: Similarity
messages: Belongs to the acylphosphatase family.

59729:MED18
gene id: 59729:MED18
uniprot id: H0Z6U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:GJB1
gene id: 59729:GJB1
uniprot id: B5KFG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Beta-type (group I) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

59729:LOC100190094
gene id: 59729:LOC100190094
uniprot id: B5FY13
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

59729:PHOSPHO2
gene id: 59729:PHOSPHO2
uniprot id: H0ZBX8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

59729:UBR2
gene id: 59729:UBR2
uniprot id: A0A674HL50
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

59729:KCNC1
gene id: 59729:KCNC1
uniprot id: A0A674H3J5
uniprot id: H0ZES6
names: Subcellular Location Annotation
messages: Membrane

59729:RPL3
gene id: 59729:RPL3
uniprot id: H0ZJ17
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

59729:LOC100222166
gene id: 59729:LOC100222166
uniprot id: H0Z5Y4
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

59729:MAN1B1
gene id: 59729:MAN1B1
uniprot id: H0YVR2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

59729:TJAP1
gene id: 59729:TJAP1
uniprot id: A0A674HCI6
names: Subcellular Location Annotation
messages: Membrane

59729:ATP5PF
gene id: 59729:ATP5PF
uniprot id: B5G0F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

59729:MINDY2
gene id: 59729:MINDY2
uniprot id: H0Z6P1
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM63 subfamily.
messages: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.

59729:TUBB4B
gene id: 59729:TUBB4B
uniprot id: B5G4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

59729:NDUFB9
gene id: 59729:NDUFB9
uniprot id: B5FZL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:GPR20
gene id: 59729:GPR20
uniprot id: H0ZR29
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:EBNA1BP2
gene id: 59729:EBNA1BP2
uniprot id: B5FZW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

59729:LOC101233328
gene id: 59729:LOC101233328
uniprot id: H0YW88
names: Similarity
names: Subcellular Location Annotation
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

59729:B2M
gene id: 59729:B2M
uniprot id: B5G1N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-2-microglobulin family.
messages: Secreted

59729:HSD3B1
gene id: 59729:HSD3B1
uniprot id: Q6SYC3
names: Similarity
messages: Belongs to the 3-beta-HSD family.

59729:LOC100190001
gene id: 59729:LOC100190001
uniprot id: B5FXD3
names: Similarity
messages: Belongs to the aldo/keto reductase family.

59729:SERPINI1
gene id: 59729:SERPINI1
uniprot id: B5G464
names: Similarity
messages: Belongs to the serpin family.

59729:TMEM177
gene id: 59729:TMEM177
uniprot id: H0Z2R3
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

59729:CRYL1
gene id: 59729:CRYL1
uniprot id: H0ZM40
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

59729:COG6
gene id: 59729:COG6
uniprot id: A0A674HA20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

59729:CDKN1B
gene id: 59729:CDKN1B
uniprot id: B5FXL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDI family.
messages: Cytoplasm
messages: Endosome
messages: Nucleus

59729:CNOT10
gene id: 59729:CNOT10
uniprot id: H0Z002
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT10 family.
messages: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.
messages: Cytoplasm
messages: Nucleus

59729:ATG101
gene id: 59729:ATG101
uniprot id: B5G0T4
names: Similarity
messages: Belongs to the ATG101 family.

59729:NME1
gene id: 59729:NME1
uniprot id: A0A674H9E8
names: Similarity
messages: Belongs to the NDK family.

59729:ALDH1A1
gene id: 59729:ALDH1A1
uniprot id: H0YRB4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

59729:GAP43
gene id: 59729:GAP43
uniprot id: A0A674HU46
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neuromodulin family.
messages: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.
messages: Cell membrane
messages: Membrane
messages: Palmitoylated. Palmitoylation is essential for plasma membrane association.
messages: Synapse
messages: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
messages: filopodium membrane
messages: growth cone membrane

59729:KCNV1
gene id: 59729:KCNV1
uniprot id: H0ZPV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

59729:CHST1
gene id: 59729:CHST1
uniprot id: H0ZKF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

59729:LOC100219265
gene id: 59729:LOC100219265
uniprot id: H0ZRL9
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

59729:PISD
gene id: 59729:PISD
uniprot id: A0A674HU15
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

59729:TIMM10
gene id: 59729:TIMM10
uniprot id: B5FXH3
names: Function
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

59729:CD9
gene id: 59729:CD9
uniprot id: B5FXC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

59729:DPM3
gene id: 59729:DPM3
uniprot id: B5FX58
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

59729:RIOK2
gene id: 59729:RIOK2
uniprot id: H0YSK4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

59729:SLC20A1
gene id: 59729:SLC20A1
uniprot id: H0YZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

59729:MALL
gene id: 59729:MALL
uniprot id: H0ZAC8
names: Subcellular Location Annotation
messages: Membrane

59729:GRIN1
gene id: 59729:GRIN1
uniprot id: Q6DUV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

59729:STEEP1
gene id: 59729:STEEP1
uniprot id: B5FZ01
names: Similarity
messages: Belongs to the STEEP1 family.

59729:BASP1
gene id: 59729:BASP1
uniprot id: B5G2C2
names: Similarity
messages: Belongs to the BASP1 family.

59729:LOC100218976
gene id: 59729:LOC100218976
uniprot id: H0ZHC5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

59729:GEMIN2
gene id: 59729:GEMIN2
uniprot id: H0ZP71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gemin-2 family.
messages: Cytoplasm
messages: Part of the core SMN complex.
messages: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs.

59729:SGSM3
gene id: 59729:SGSM3
uniprot id: A0A674GVM6
names: Similarity
messages: Belongs to the small G protein signaling modulator family.

59729:RPL35A
gene id: 59729:RPL35A
uniprot id: B5FYA0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

59729:MAD1L1
gene id: 59729:MAD1L1
uniprot id: A0A674HL44
uniprot id: H0ZCY8
names: Similarity
messages: Belongs to the MAD1 family.

59729:HTR2C
gene id: 59729:HTR2C
uniprot id: A0A674HUW1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with MPDZ. Interacts with ARRB2.
messages: Membrane

59729:LOC100219012
gene id: 59729:LOC100219012
uniprot id: H0YQP8
names: Similarity
messages: Belongs to the FBPase class 1 family.

59729:PRXL2A
gene id: 59729:PRXL2A
uniprot id: B5G352
uniprot id: B5G355
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.
messages: Cytoplasm

59729:LOC100223994
gene id: 59729:LOC100223994
uniprot id: H0ZN48
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:LOC100220412
gene id: 59729:LOC100220412
uniprot id: H0YUD8
names: Similarity
messages: Belongs to the avidin/streptavidin family.

59729:TPH2
gene id: 59729:TPH2
uniprot id: H0ZAE3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

59729:ATP6V1A
gene id: 59729:ATP6V1A
uniprot id: A0A674GTZ4
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.

59729:USE1
gene id: 59729:USE1
uniprot id: A0A674GAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:SOSTDC1
gene id: 59729:SOSTDC1
uniprot id: A0A674G711
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:PNPLA4
gene id: 59729:PNPLA4
uniprot id: H0ZE01
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:ATP6AP1L
gene id: 59729:ATP6AP1L
uniprot id: H0Z985
names: Similarity
messages: Belongs to the vacuolar ATPase subunit S1 family.

59729:ELAVL2
gene id: 59729:ELAVL2
uniprot id: A0A674HHL6
uniprot id: H0YSY6
names: Similarity
messages: Belongs to the RRM elav family.

59729:VPS4B
gene id: 59729:VPS4B
uniprot id: H0YUZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

59729:NDUFB4
gene id: 59729:NDUFB4
uniprot id: B5G2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:ABI2
gene id: 59729:ABI2
uniprot id: H0ZHI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

59729:DTX3L
gene id: 59729:DTX3L
uniprot id: H0Z099
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

59729:GDNF
gene id: 59729:GDNF
uniprot id: A0A674GT80
uniprot id: A0A674H3U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

59729:LOC100228204
gene id: 59729:LOC100228204
uniprot id: B5FXC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:ECHDC1
gene id: 59729:ECHDC1
uniprot id: A0A674HVI8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

59729:FAM83B
gene id: 59729:FAM83B
uniprot id: H0ZRI3
names: Similarity
messages: Belongs to the FAM83 family.

59729:MND1
gene id: 59729:MND1
uniprot id: H0Z3X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus
messages: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.

59729:CNKSR2
gene id: 59729:CNKSR2
uniprot id: H0ZAS6
names: Similarity
messages: Belongs to the CNKSR family.

59729:PHETA1
gene id: 59729:PHETA1
uniprot id: H0Z7W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sesquipedalian family.
messages: Early endosome
messages: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
messages: Recycling endosome
messages: clathrin-coated vesicle
messages: trans-Golgi network

59729:GOLPH3
gene id: 59729:GOLPH3
uniprot id: H0YUJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

59729:TIMM22
gene id: 59729:TIMM22
uniprot id: B5FZU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

59729:KIN
gene id: 59729:KIN
uniprot id: H0YV65
names: Similarity
messages: Belongs to the KIN17 family.

59729:TAF15
gene id: 59729:TAF15
uniprot id: H0Z2T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TET family.
messages: Nucleus

59729:SLC24A2
gene id: 59729:SLC24A2
uniprot id: H0Z1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

59729:TAT
gene id: 59729:TAT
uniprot id: A0A674G907
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.

59729:GPM6A
gene id: 59729:GPM6A
uniprot id: H0Z7K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Membrane

59729:RPA1
gene id: 59729:RPA1
uniprot id: H0Z5X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

59729:VEGFD
gene id: 59729:VEGFD
uniprot id: H0ZCM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Secreted

59729:MPPED2
gene id: 59729:MPPED2
uniprot id: A0A674H9Y6
names: Similarity
messages: Belongs to the UPF0046 family.

59729:SYNPR
gene id: 59729:SYNPR
uniprot id: A0A674H1P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

59729:LIPI
gene id: 59729:LIPI
uniprot id: H0ZTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

59729:ZFYVE27
gene id: 59729:ZFYVE27
uniprot id: H0ZH27
uniprot id: H0ZH30
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: growth cone membrane

59729:PTGR2
gene id: 59729:PTGR2
uniprot id: B5FYK7
names: Similarity
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.

59729:ST8SIA4
gene id: 59729:ST8SIA4
uniprot id: H0YRL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

59729:LOC100226875
gene id: 59729:LOC100226875
uniprot id: H0ZQQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR0 subfamily.
messages: Cytoplasm
messages: Nucleus

59729:NDRG3
gene id: 59729:NDRG3
uniprot id: A0A674HPF7
names: Similarity
messages: Belongs to the NDRG family.

59729:NDUFB2
gene id: 59729:NDUFB2
uniprot id: B5G0G6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:RNF121
gene id: 59729:RNF121
uniprot id: B5FY54
names: Subcellular Location Annotation
messages: Membrane

59729:SIRT4
gene id: 59729:SIRT4
uniprot id: H0ZGT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Mitochondrion matrix
messages: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

59729:FKTN
gene id: 59729:FKTN
uniprot id: H0Z7E9
names: Similarity
messages: Belongs to the LicD transferase family.

59729:LOC100230571
gene id: 59729:LOC100230571
uniprot id: A0A674G9K1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with UHRF2/NIRF.
messages: May be involved in cell cycle regulation.
messages: Nucleus

59729:NUP35
gene id: 59729:NUP35
uniprot id: B5FXW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nup35 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

59729:CDH12
gene id: 59729:CDH12
uniprot id: H0YUL2
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

59729:FDFT1
gene id: 59729:FDFT1
uniprot id: A0A674HU74
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

59729:PNRC2
gene id: 59729:PNRC2
uniprot id: A0A674GAY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNRC family. PNRC2 subfamily.
messages: Nucleus
messages: P-body

59729:SRP19
gene id: 59729:SRP19
uniprot id: B5FY28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

59729:RPS21
gene id: 59729:RPS21
uniprot id: B5FYM5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

59729:ANO3
gene id: 59729:ANO3
uniprot id: A0A674GNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Membrane

59729:POLR2E
gene id: 59729:POLR2E
uniprot id: B5FX59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
messages: Nucleus

59729:B3GNT2
gene id: 59729:B3GNT2
uniprot id: H0YVG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

59729:LOC105758845
gene id: 59729:LOC105758845
uniprot id: A0A674GDG2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:KCND2
gene id: 59729:KCND2
uniprot id: H0Z2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane
messages: Perikaryon
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane
messages: dendrite
messages: dendritic spine

59729:CDC42SE1
gene id: 59729:CDC42SE1
uniprot id: H0Z2X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

59729:KCNJ2
gene id: 59729:KCNJ2
uniprot id: H0YXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

59729:PSMA6
gene id: 59729:PSMA6
uniprot id: B5FXD0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

59729:TSHZ1
gene id: 59729:TSHZ1
uniprot id: A0A674H6E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

59729:LSM5
gene id: 59729:LSM5
uniprot id: B5G480
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

59729:RTN1
gene id: 59729:RTN1
uniprot id: B5G288
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:HADH
gene id: 59729:HADH
uniprot id: H0Z0N4
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

59729:ENPP4
gene id: 59729:ENPP4
uniprot id: H0ZSP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
messages: Cell membrane
messages: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.
messages: Membrane

59729:PFDN4
gene id: 59729:PFDN4
uniprot id: B5FYT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

59729:ACSL4
gene id: 59729:ACSL4
uniprot id: A0A674GDY0
uniprot id: A0A674H646
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

59729:PRPF18
gene id: 59729:PRPF18
uniprot id: H0YVP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

59729:LOC100231656
gene id: 59729:LOC100231656
uniprot id: H0Z1I9
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:TINAG
gene id: 59729:TINAG
uniprot id: H0ZRI4
names: Similarity
messages: Belongs to the peptidase C1 family.

59729:PLN
gene id: 59729:PLN
uniprot id: A0A674GSS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

59729:SERF2
gene id: 59729:SERF2
uniprot id: B5G4D4
names: Similarity
messages: Belongs to the SERF family.

59729:ACSL5
gene id: 59729:ACSL5
uniprot id: H0ZKJ7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.

59729:YWHAG
gene id: 59729:YWHAG
uniprot id: B5G028
names: Similarity
messages: Belongs to the 14-3-3 family.

59729:SNU13
gene id: 59729:SNU13
uniprot id: B5FZ04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

59729:LOC100230121
gene id: 59729:LOC100230121
uniprot id: H0ZN96
names: Similarity
messages: Belongs to the calcitonin family.

59729:CLUAP1
gene id: 59729:CLUAP1
uniprot id: A0A674GYB2
uniprot id: H0Z087
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

59729:EIF2AK3
gene id: 59729:EIF2AK3
uniprot id: H0ZKV7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

59729:EFEMP1
gene id: 59729:EFEMP1
uniprot id: H0Z947
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:C3H6orf120
gene id: 59729:C3H6orf120
uniprot id: A0A674H696
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: Secreted

59729:CDC26
gene id: 59729:CDC26
uniprot id: B5FXX3
names: Similarity
messages: Belongs to the CDC26 family.

59729:GEM
gene id: 59729:GEM
uniprot id: H0ZNR0
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

59729:SEC23B
gene id: 59729:SEC23B
uniprot id: A0A674HM95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

59729:TAF13
gene id: 59729:TAF13
uniprot id: B5FYP3
names: Subcellular Location Annotation
messages: Nucleus

59729:RTCA
gene id: 59729:RTCA
uniprot id: H0Z446
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

59729:LOC100221073
gene id: 59729:LOC100221073
uniprot id: H0ZSP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:AIFM2
gene id: 59729:AIFM2
uniprot id: B5FXE5
names: Activity Regulation
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: A NAD(P)H-dependent oxidoreductase that acts as a key inhibitor of ferroptosis. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Acts in parallel to GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. Also acts as a potent radical-trapping antioxidant by mediating warfarin-resistant vitamin K reduction in the canonical vitamin K cycle: catalyzes NAD(P)H-dependent reduction of vitamin K (phylloquinone, menaquinone-4 and menadione) to hydroquinone forms. Hydroquinones act as potent radical-trapping antioxidants inhibitor of phospholipid peroxidation and ferroptosis. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death.
messages: Belongs to the FAD-dependent oxidoreductase family.
messages: Binds 6-hydroxy-FAD non-covalently.
messages: Cell membrane
messages: Cytoplasm
messages: Lipid droplet
messages: Mitochondrion membrane
messages: N-myristoylation at Gly-2 mediates the recruitment to lipid droplets and plasma membrane.
messages: Nucleus
messages: The modification by 4-hydroxy-2-nonenal (HNE) adduction in mitochondria results in loss of the oxidoreductase activity and activation of a novel function in mitochondrial oxidative stress signaling.

59729:CCNG2
gene id: 59729:CCNG2
uniprot id: H0YU20
names: Similarity
messages: Belongs to the cyclin family.

59729:PRKRIP1
gene id: 59729:PRKRIP1
uniprot id: B5G201
names: Similarity
messages: Belongs to the PRKRIP1 family.

59729:STMN2
gene id: 59729:STMN2
uniprot id: B5KFG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stathmin family.
messages: Cytoplasm
messages: Membrane
messages: lamellipodium

59729:SRP68
gene id: 59729:SRP68
uniprot id: H0ZCP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

59729:OPN5
gene id: 59729:OPN5
uniprot id: A0A674HDZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:MED13
gene id: 59729:MED13
uniprot id: H0ZBK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

59729:HMGN3
gene id: 59729:HMGN3
uniprot id: B5G1B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

59729:PLP1
gene id: 59729:PLP1
uniprot id: P47790
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin proteolipid protein family.
messages: Cell membrane
messages: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

59729:ADD3
gene id: 59729:ADD3
uniprot id: A0A674GVA5
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

59729:LOC100218354
gene id: 59729:LOC100218354
uniprot id: B5G047
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

59729:NUBP2
gene id: 59729:NUBP2
uniprot id: H0YZE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.

59729:RTRAF
gene id: 59729:RTRAF
uniprot id: B5G0L3
names: Similarity
messages: Belongs to the RTRAF family.

59729:GABRA1
gene id: 59729:GABRA1
uniprot id: H0YT92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

59729:PLLP
gene id: 59729:PLLP
uniprot id: B5FXB0
names: Subcellular Location Annotation
messages: Membrane

59729:SLC6A17
gene id: 59729:SLC6A17
uniprot id: A0A674HE88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

59729:DMBX1
gene id: 59729:DMBX1
uniprot id: H0ZDE1
names: Subcellular Location Annotation
messages: Nucleus

59729:ATP6V0D1
gene id: 59729:ATP6V0D1
uniprot id: H0Z662
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

59729:TUBB1
gene id: 59729:TUBB1
uniprot id: H0ZCG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

59729:LGI1
gene id: 59729:LGI1
uniprot id: A0A674HRG8
names: Subcellular Location Annotation
messages: Secreted

59729:GLO1
gene id: 59729:GLO1
uniprot id: B5FYL6
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

59729:POLR3A
gene id: 59729:POLR3A
uniprot id: H0Z7T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

59729:SOD1
gene id: 59729:SOD1
uniprot id: B5G2U2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

59729:BTBD10
gene id: 59729:BTBD10
uniprot id: B5FZS3
names: Subcellular Location Annotation
messages: Cytoplasm

59729:RPL26L1
gene id: 59729:RPL26L1
uniprot id: B5G053
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

59729:LOC100189940
gene id: 59729:LOC100189940
uniprot id: B5FX53
names: Similarity
messages: Belongs to the HINT family.

59729:TSPAN5
gene id: 59729:TSPAN5
uniprot id: A0A674H3K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

59729:MAFK
gene id: 59729:MAFK
uniprot id: A0A674HV58
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

59729:SCARB2
gene id: 59729:SCARB2
uniprot id: B5FY06
names: Similarity
messages: Belongs to the CD36 family.

59729:CHST4
gene id: 59729:CHST4
uniprot id: H0ZDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

59729:PTS
gene id: 59729:PTS
uniprot id: B5G4P7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

59729:LSM1
gene id: 59729:LSM1
uniprot id: B5FZU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Cytoplasm
messages: LSm subunits form a heteromer with a donut shape.
messages: P-body
messages: Probably involved with other LSm subunits in the general process of degradation of mRNAs.

59729:SLC7A3
gene id: 59729:SLC7A3
uniprot id: A0A674GPY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

59729:LOC100217677
gene id: 59729:LOC100217677
uniprot id: H0ZJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the noggin family.
messages: Secreted

59729:MICOS10
gene id: 59729:MICOS10
uniprot id: B5G172
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

59729:PDE6B
gene id: 59729:PDE6B
uniprot id: H0YPK4
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

59729:PSMB2
gene id: 59729:PSMB2
uniprot id: H0YTV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

59729:RARS2
gene id: 59729:RARS2
uniprot id: A0A674H7E7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

59729:ANAPC13
gene id: 59729:ANAPC13
uniprot id: B5G2E3
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

59729:SPRING1
gene id: 59729:SPRING1
uniprot id: H0ZJ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPRING family.
messages: Golgi apparatus membrane
messages: Membrane

59729:DGCR2
gene id: 59729:DGCR2
uniprot id: H0ZF22
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:KEG28 p01
gene id: 59729:KEG28_p01
uniprot id: Q27GV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Mitochondrion membrane

59729:CCND2
gene id: 59729:CCND2
uniprot id: H0ZPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

59729:P2RY4
gene id: 59729:P2RY4
uniprot id: H0YWR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:CTNNB1
gene id: 59729:CTNNB1
uniprot id: H0Z303
names: Similarity
messages: Belongs to the beta-catenin family.

59729:BCCIP
gene id: 59729:BCCIP
uniprot id: B5FXE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: spindle pole

59729:GREM1
gene id: 59729:GREM1
uniprot id: A0A674G9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

59729:TFB1M
gene id: 59729:TFB1M
uniprot id: H0ZLK5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

59729:FGB
gene id: 59729:FGB
uniprot id: H0Z4C6
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

59729:SAT1
gene id: 59729:SAT1
uniprot id: B5FYC2
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Homodimer.

59729:MEAF6
gene id: 59729:MEAF6
uniprot id: B5FZP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
messages: Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.
messages: kinetochore
messages: nucleolus

59729:PSIP1
gene id: 59729:PSIP1
uniprot id: H0Z283
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HDGF family.
messages: Nucleus

59729:CBWD1
gene id: 59729:CBWD1
uniprot id: H0Z5F1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

59729:LAPTM5
gene id: 59729:LAPTM5
uniprot id: H0YRB1
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

59729:UBE3A
gene id: 59729:UBE3A
uniprot id: H0ZJ61
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
messages: Nucleus

59729:GNRH1
gene id: 59729:GNRH1
uniprot id: B7TCA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted

59729:ACBD5
gene id: 59729:ACBD5
uniprot id: A0A674H6W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.
messages: Belongs to the ATG37 family.
messages: Membrane

59729:RPS6
gene id: 59729:RPS6
uniprot id: B5FYB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

59729:ATRNL1
gene id: 59729:ATRNL1
uniprot id: A0A674HPP4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:CLTB
gene id: 59729:CLTB
uniprot id: A0A674GU09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

59729:KCNJ4
gene id: 59729:KCNJ4
uniprot id: A0A674HE84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

59729:TMEM267
gene id: 59729:TMEM267
uniprot id: A0A674HSI5
names: Subcellular Location Annotation
messages: Membrane

59729:FADS1
gene id: 59729:FADS1
uniprot id: A0A674GB81
names: Similarity
messages: Belongs to the fatty acid desaturase type 1 family.

59729:PRDX6
gene id: 59729:PRDX6
uniprot id: B5G0S1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

59729:LEPR
gene id: 59729:LEPR
uniprot id: H0ZIF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Membrane

59729:GABPA
gene id: 59729:GABPA
uniprot id: H0ZTL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

59729:ASCC3
gene id: 59729:ASCC3
uniprot id: H0ZPV5
names: Similarity
messages: Belongs to the helicase family.

59729:LOC100228865
gene id: 59729:LOC100228865
uniprot id: H1A527
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Cytoplasm
messages: Reversible hydration of carbon dioxide.

59729:LOC100218573
gene id: 59729:LOC100218573
uniprot id: H0YP10
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:UBE2F
gene id: 59729:UBE2F
uniprot id: A0A674H8W5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:VAMP7
gene id: 59729:VAMP7
uniprot id: H0Z4X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

59729:TRIAP1
gene id: 59729:TRIAP1
uniprot id: A0A674HTG2
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

59729:LDB2
gene id: 59729:LDB2
uniprot id: A0A674HJA5
names: Similarity
messages: Belongs to the LDB family.

59729:SMCO4
gene id: 59729:SMCO4
uniprot id: B5FXC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMCO4 family.
messages: Membrane

59729:FYN
gene id: 59729:FYN
uniprot id: A0A674GHS3
uniprot id: H0ZP43
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

59729:HTR1F
gene id: 59729:HTR1F
uniprot id: H0ZTI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
messages: Membrane

59729:LOC100219548
gene id: 59729:LOC100219548
uniprot id: H0ZM34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

59729:LOC100190585
gene id: 59729:LOC100190585
uniprot id: B5G106
names: Similarity
messages: Belongs to the globin family.

59729:PRRC1
gene id: 59729:PRRC1
uniprot id: A0A674GUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRRC1 family.
messages: Golgi apparatus

59729:CNEP1R1
gene id: 59729:CNEP1R1
uniprot id: A0A674H5W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

59729:CYP19A1
gene id: 59729:CYP19A1
uniprot id: Q92112
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
messages: Membrane

59729:NFS1
gene id: 59729:NFS1
uniprot id: H0YXW1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

59729:PSMA2
gene id: 59729:PSMA2
uniprot id: B5G154
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

59729:PCMTD1
gene id: 59729:PCMTD1
uniprot id: A0A674G8J0
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

59729:SLC25A34
gene id: 59729:SLC25A34
uniprot id: H0YV15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:DLL4
gene id: 59729:DLL4
uniprot id: H0ZKJ0
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

59729:SULT4A1
gene id: 59729:SULT4A1
uniprot id: B5G2M5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

59729:RPS23
gene id: 59729:RPS23
uniprot id: B5FZK6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the 40S small ribosomal subunit.
messages: Rough endoplasmic reticulum

59729:GLDC
gene id: 59729:GLDC
uniprot id: H0Z3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

59729:LHX8
gene id: 59729:LHX8
uniprot id: H0ZJH3
names: Subcellular Location Annotation
messages: Nucleus

59729:PLAGL1
gene id: 59729:PLAGL1
uniprot id: A0A674H1C7
names: Subcellular Location Annotation
messages: Nucleus

59729:MSRA
gene id: 59729:MSRA
uniprot id: H0ZSW6
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

59729:HAS2
gene id: 59729:HAS2
uniprot id: H0ZQ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NodC/HAS family.
messages: Endoplasmic reticulum membrane
messages: Lysosome
messages: Membrane

59729:SNCB
gene id: 59729:SNCB
uniprot id: B5FYR9
names: Similarity
messages: Belongs to the synuclein family.

59729:EIF2B5
gene id: 59729:EIF2B5
uniprot id: H0ZIK9
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

59729:CENPI
gene id: 59729:CENPI
uniprot id: A0A674GK53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

59729:CAPN9
gene id: 59729:CAPN9
uniprot id: H0ZI51
names: Similarity
messages: Belongs to the peptidase C2 family.

59729:SLC7A2
gene id: 59729:SLC7A2
uniprot id: A0A674GP60
uniprot id: H0ZA12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

59729:PTAFR
gene id: 59729:PTAFR
uniprot id: A0A674H035
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with ARRB1.
messages: Membrane

59729:SLC7A6OS
gene id: 59729:SLC7A6OS
uniprot id: B5FYZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWR1/SLC7A6OS family.
messages: Cytoplasm
messages: Directs RNA polymerase II nuclear import.
messages: Nucleus

59729:MBP
gene id: 59729:MBP
uniprot id: B5G2D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myelin basic protein family.
messages: Myelin membrane

59729:NIM1K
gene id: 59729:NIM1K
uniprot id: A0A674GGS9
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:MOXD1
gene id: 59729:MOXD1
uniprot id: H0ZN04
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

59729:SCAMP4
gene id: 59729:SCAMP4
uniprot id: A0A674H7J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

59729:CENPK
gene id: 59729:CENPK
uniprot id: H0YX88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

59729:FCF1
gene id: 59729:FCF1
uniprot id: A0A674HJ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

59729:LOC100226754
gene id: 59729:LOC100226754
uniprot id: H0YUV2
names: Similarity
messages: Belongs to the centrin family.

59729:PSEN2
gene id: 59729:PSEN2
uniprot id: H0Z1M3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

59729:FAM131B
gene id: 59729:FAM131B
uniprot id: A0A674GDT3
names: Similarity
messages: Belongs to the FAM131 family.

59729:ATP6V0B
gene id: 59729:ATP6V0B
uniprot id: B5G4H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: clathrin-coated vesicle membrane

59729:LITAF
gene id: 59729:LITAF
uniprot id: A0A674H5B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane
messages: Membrane

59729:MITF
gene id: 59729:MITF
uniprot id: H0ZHV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

59729:LOC100223320
gene id: 59729:LOC100223320
uniprot id: A0A674GHD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

59729:FOXP4
gene id: 59729:FOXP4
uniprot id: K4EN27
names: Subcellular Location Annotation
messages: Nucleus

59729:FABP3
gene id: 59729:FABP3
uniprot id: B5FX90
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:TMEM200A
gene id: 59729:TMEM200A
uniprot id: A0A674HE10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

59729:CNOT7
gene id: 59729:CNOT7
uniprot id: H0ZA68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

59729:STAC
gene id: 59729:STAC
uniprot id: H0YTX9
names: Subcellular Location Annotation
messages: sarcolemma

59729:GRIA2
gene id: 59729:GRIA2
uniprot id: Q76MR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

59729:IMMP1L
gene id: 59729:IMMP1L
uniprot id: B5FZA7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

59729:BCL2A1
gene id: 59729:BCL2A1
uniprot id: H0ZCL9
names: Similarity
messages: Belongs to the Bcl-2 family.

59729:GTF2H5
gene id: 59729:GTF2H5
uniprot id: B5G1G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

59729:LOC100221179
gene id: 59729:LOC100221179
uniprot id: H0ZEI2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

59729:CHMP5
gene id: 59729:CHMP5
uniprot id: B5G281
names: Similarity
messages: Belongs to the SNF7 family.

59729:RPS28
gene id: 59729:RPS28
uniprot id: B5FY09
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

59729:CDK14
gene id: 59729:CDK14
uniprot id: A0A674HKU7
uniprot id: H0YT72
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:CAND1
gene id: 59729:CAND1
uniprot id: H0Z8J5
names: Similarity
messages: Belongs to the CAND family.

59729:EFNB2
gene id: 59729:EFNB2
uniprot id: A0A674GMS7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:NDUFA6
gene id: 59729:NDUFA6
uniprot id: B5G1U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I LYR family.
messages: Mammalian complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:NDUFA12
gene id: 59729:NDUFA12
uniprot id: B5G168
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:ATG16L1
gene id: 59729:ATG16L1
uniprot id: H0ZAN7
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

59729:PRR5L
gene id: 59729:PRR5L
uniprot id: H0ZIN6
names: Similarity
messages: Belongs to the PROTOR family.

59729:CDC42EP3
gene id: 59729:CDC42EP3
uniprot id: H0ZES1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

59729:LOC100229710
gene id: 59729:LOC100229710
uniprot id: B5G3N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

59729:LOC100190340
gene id: 59729:LOC100190340
uniprot id: B5G0J1
names: Similarity
messages: Belongs to the SNF7 family.

59729:OAZ2
gene id: 59729:OAZ2
uniprot id: H0Z2Q7
names: Similarity
messages: Belongs to the ODC antizyme family.

59729:LOC100228379
gene id: 59729:LOC100228379
uniprot id: H0Z1C6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Has antiviral activities.
messages: Secreted

59729:YIPF1
gene id: 59729:YIPF1
uniprot id: B5FZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

59729:GGACT
gene id: 59729:GGACT
uniprot id: A0A674HVZ4
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.

59729:ARL3
gene id: 59729:ARL3
uniprot id: B5FYQ4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

59729:PPA1
gene id: 59729:PPA1
uniprot id: B5KFF6
names: Similarity
messages: Belongs to the PPase family.

59729:RPP14
gene id: 59729:RPP14
uniprot id: B5FXA5
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

59729:NDUFA3
gene id: 59729:NDUFA3
uniprot id: B5G0G5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Membrane
messages: Mitochondrion inner membrane

59729:LCA5
gene id: 59729:LCA5
uniprot id: H0ZQR6
names: Similarity
messages: Belongs to the LCA5 family.

59729:EIF2B2
gene id: 59729:EIF2B2
uniprot id: B5FYM1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

59729:CACNG1
gene id: 59729:CACNG1
uniprot id: H0Z1T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.
messages: Membrane
messages: Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.
messages: sarcolemma

59729:MFSD10
gene id: 59729:MFSD10
uniprot id: H0ZJM7
names: Subcellular Location Annotation
messages: Membrane

59729:HPCAL1
gene id: 59729:HPCAL1
uniprot id: B5FZ84
names: Miscellaneous
names: Similarity
messages: Belongs to the recoverin family.
messages: Probably binds two or three calcium ions.

59729:SLC16A7
gene id: 59729:SLC16A7
uniprot id: A0A674HNK3
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cytoplasm
messages: Membrane

59729:TUBGCP3
gene id: 59729:TUBGCP3
uniprot id: H0ZF74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
messages: centrosome

59729:ATG5
gene id: 59729:ATG5
uniprot id: A0A674HBJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

59729:PPIC
gene id: 59729:PPIC
uniprot id: B5KFI6
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:RC3H2
gene id: 59729:RC3H2
uniprot id: H0Z973
names: Subcellular Location Annotation
messages: P-body

59729:OSBPL1A
gene id: 59729:OSBPL1A
uniprot id: H0ZJV8
names: Similarity
messages: Belongs to the OSBP family.

59729:LOC100222004
gene id: 59729:LOC100222004
uniprot id: H0Z1I4
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:UBE2I
gene id: 59729:UBE2I
uniprot id: B5FZW7
uniprot id: H0ZH10
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

59729:ANXA6
gene id: 59729:ANXA6
uniprot id: H0YRC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

59729:EIF4E2
gene id: 59729:EIF4E2
uniprot id: H0ZI64
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

59729:NT5C3A
gene id: 59729:NT5C3A
uniprot id: A0A674H9T8
uniprot id: H0Z4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

59729:TMEM167A
gene id: 59729:TMEM167A
uniprot id: B5G2S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.

59729:OTULINL
gene id: 59729:OTULINL
uniprot id: H0ZAQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

59729:REEP3
gene id: 59729:REEP3
uniprot id: A0A674H7I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

59729:TPRG1L
gene id: 59729:TPRG1L
uniprot id: H0YX21
names: Similarity
messages: Belongs to the TPRG1 family.

59729:SLC25A19
gene id: 59729:SLC25A19
uniprot id: A0A674H2J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:DHFR
gene id: 59729:DHFR
uniprot id: H0Z9R7
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

59729:KEG28 p12
gene id: 59729:KEG28_p12
uniprot id: Q27GW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

59729:TBC1D7
gene id: 59729:TBC1D7
uniprot id: H0Z636
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

59729:PSMA4
gene id: 59729:PSMA4
uniprot id: B5FXX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

59729:CDH7
gene id: 59729:CDH7
uniprot id: A0A674GM13
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

59729:LOC100231234
gene id: 59729:LOC100231234
uniprot id: A0A674GFS1
uniprot id: H0YXV7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

59729:HEXB
gene id: 59729:HEXB
uniprot id: H0Z6E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

59729:SLC39A3
gene id: 59729:SLC39A3
uniprot id: A0A674HEH8
names: Subcellular Location Annotation
messages: Membrane

59729:EZH2
gene id: 59729:EZH2
uniprot id: A0A674H2E7
names: Subcellular Location Annotation
messages: Nucleus

59729:CCK
gene id: 59729:CCK
uniprot id: B5FZ02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

59729:CKS2
gene id: 59729:CKS2
uniprot id: H0YQA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

59729:LOC100218025
gene id: 59729:LOC100218025
uniprot id: H0ZDP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Midbody
messages: cilium membrane
messages: spindle

59729:APOA1
gene id: 59729:APOA1
uniprot id: B5G356
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

59729:TAF10
gene id: 59729:TAF10
uniprot id: B5G075
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus

59729:GRIA3
gene id: 59729:GRIA3
uniprot id: H0YZP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

59729:RORB
gene id: 59729:RORB
uniprot id: A0A674GCR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

59729:KIF24
gene id: 59729:KIF24
uniprot id: A0A674HH25
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

59729:ALDH8A1
gene id: 59729:ALDH8A1
uniprot id: A0A674H3H0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

59729:LOC100221679
gene id: 59729:LOC100221679
uniprot id: A0A674HLL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

59729:OSTC
gene id: 59729:OSTC
uniprot id: H0Z0U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

59729:SNW1
gene id: 59729:SNW1
uniprot id: A0A674H4B1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

59729:WDFY1
gene id: 59729:WDFY1
uniprot id: H0ZC67
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

59729:AR
gene id: 59729:AR
uniprot id: Q2VP86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

59729:BTF3
gene id: 59729:BTF3
uniprot id: B5FXB9
names: Similarity
messages: Belongs to the NAC-beta family.

59729:RPL37A
gene id: 59729:RPL37A
uniprot id: H0Z3V9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

59729:TPT1
gene id: 59729:TPT1
uniprot id: B5FZD8
names: Similarity
messages: Belongs to the TCTP family.

59729:LOC100228825
gene id: 59729:LOC100228825
uniprot id: H0ZP91
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

59729:OLFM3
gene id: 59729:OLFM3
uniprot id: A0A674GJD3
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

59729:CRH
gene id: 59729:CRH
uniprot id: B5FXS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

59729:MB
gene id: 59729:MB
uniprot id: H0ZKN4
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

59729:NECAP1
gene id: 59729:NECAP1
uniprot id: A0A674GM92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

59729:PPFIBP1
gene id: 59729:PPFIBP1
uniprot id: A0A674HJ85
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

59729:NDUFA1
gene id: 59729:NDUFA1
uniprot id: B5G1H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

59729:SERPINB5
gene id: 59729:SERPINB5
uniprot id: H0YV05
names: Similarity
messages: Belongs to the serpin family. Ov-serpin subfamily.

59729:LDHB
gene id: 59729:LDHB
uniprot id: B5G2G0
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

59729:DYNLT1
gene id: 59729:DYNLT1
uniprot id: B5FXR4
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

59729:ACO1
gene id: 59729:ACO1
uniprot id: H0YTE6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.
messages: cytosol

59729:LOC121468025
gene id: 59729:LOC121468025
uniprot id: A0A674GU45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

59729:ELK3
gene id: 59729:ELK3
uniprot id: A0A674H9W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

59729:LOC100232776
gene id: 59729:LOC100232776
uniprot id: H0Z842
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

59729:BNIP1
gene id: 59729:BNIP1
uniprot id: B5FXM7
names: Subcellular Location Annotation
messages: Membrane

59729:VPS35L
gene id: 59729:VPS35L
uniprot id: A0A674H4W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS35L family.
messages: Endosome

59729:ABCG5
gene id: 59729:ABCG5
uniprot id: A0A674HR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

59729:UQCR10
gene id: 59729:UQCR10
uniprot id: B5G1I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

59729:NOL12
gene id: 59729:NOL12
uniprot id: B5FY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

59729:MMGT1
gene id: 59729:MMGT1
uniprot id: A0A674HMY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

59729:POLR2J
gene id: 59729:POLR2J
uniprot id: B5G2R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

59729:TCEA2
gene id: 59729:TCEA2
uniprot id: B5G3L7
names: Subcellular Location Annotation
messages: Nucleus

59729:GNPDA2
gene id: 59729:GNPDA2
uniprot id: H0ZDN6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

59729:LOC105759119
gene id: 59729:LOC105759119
uniprot id: H0ZSM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

59729:GNG12
gene id: 59729:GNG12
uniprot id: B5KFK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

59729:SLC12A2
gene id: 59729:SLC12A2
uniprot id: H0Z8B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Cell membrane
messages: Membrane

59729:GATA4
gene id: 59729:GATA4
uniprot id: A0A674GCP6
uniprot id: A0A674HPU7
names: Subcellular Location Annotation
messages: Nucleus

59729:PFDN1
gene id: 59729:PFDN1
uniprot id: B5G1I3
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

59729:AGPAT5
gene id: 59729:AGPAT5
uniprot id: B5FXF9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

59729:LOC100220807
gene id: 59729:LOC100220807
uniprot id: A0A674GMJ5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

59729:EIF4E
gene id: 59729:EIF4E
uniprot id: B5FX97
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

59729:LOC100189978
gene id: 59729:LOC100189978
uniprot id: B5FXA3
names: Similarity
messages: Belongs to the janus family.

59729:GET4
gene id: 59729:GET4
uniprot id: B5KFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
messages: Belongs to the GET4 family.
messages: Component of the BAG6/BAT3 complex.
messages: cytosol

59729:ARPP19
gene id: 59729:ARPP19
uniprot id: B5G1C4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the endosulfine family.
messages: Cytoplasm
messages: Interacts (when phosphorylated at Ser-62) with PPP2R2D.
messages: Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.
messages: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).

59729:POLR3B
gene id: 59729:POLR3B
uniprot id: A0A674GK25
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

59729:NRDC
gene id: 59729:NRDC
uniprot id: H0ZEY8
names: Similarity
messages: Belongs to the peptidase M16 family.

59729:UQCRH
gene id: 59729:UQCRH
uniprot id: B5G1C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

59729:LOC100226705
gene id: 59729:LOC100226705
uniprot id: H0YSF2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

59729:CD81
gene id: 59729:CD81
uniprot id: A0A674GNI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

59729:FSCN1
gene id: 59729:FSCN1
uniprot id: B5FYS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

59729:METAP1
gene id: 59729:METAP1
uniprot id: H0YYQ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

59729:KCNAB2
gene id: 59729:KCNAB2
uniprot id: H0YWU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

59729:SNRPG
gene id: 59729:SNRPG
uniprot id: B5FZB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

59729:APRT
gene id: 59729:APRT
uniprot id: B5FX92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm

59729:LOC100219615
gene id: 59729:LOC100219615
uniprot id: A0A674GY87
uniprot id: H0ZH32
names: Similarity
messages: Belongs to the Luc7 family.

59729:SLC25A27
gene id: 59729:SLC25A27
uniprot id: B5FXG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:LOC100225836
gene id: 59729:LOC100225836
uniprot id: A0A674HFR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 7B2 family.
messages: Secreted

59729:ATP5F1D
gene id: 59729:ATP5F1D
uniprot id: B5FZC5
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

59729:AIG1
gene id: 59729:AIG1
uniprot id: A0A674GQV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

59729:CFAP298
gene id: 59729:CFAP298
uniprot id: B5FXS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP298 family.
messages: cilium basal body

59729:SMAD2
gene id: 59729:SMAD2
uniprot id: A0A674HM63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

59729:LOC100221958
gene id: 59729:LOC100221958
uniprot id: H0ZAG2
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

59729:FAM234A
gene id: 59729:FAM234A
uniprot id: H0Z1G1
names: Similarity
messages: Belongs to the FAM234 family.

59729:LOC100220507
gene id: 59729:LOC100220507
uniprot id: H0ZDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

59729:OPN1SW
gene id: 59729:OPN1SW
uniprot id: Q9I8R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

59729:DAD1
gene id: 59729:DAD1
uniprot id: B5FXK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

59729:TMEM30A
gene id: 59729:TMEM30A
uniprot id: H0ZQX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC50/LEM3 family.
messages: Cell membrane
messages: Golgi apparatus
messages: Membrane
messages: secretory vesicle membrane

59729:MYF6
gene id: 59729:MYF6
uniprot id: H0ZBL8
names: Subcellular Location Annotation
messages: Nucleus

59729:MAP3K21
gene id: 59729:MAP3K21
uniprot id: H0ZIV1
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

59729:FOXP2
gene id: 59729:FOXP2
uniprot id: Q6QBA5
names: Subcellular Location Annotation
messages: Nucleus

59729:PFDN2
gene id: 59729:PFDN2
uniprot id: B5FXU2
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

59729:CLDN12
gene id: 59729:CLDN12
uniprot id: A0A674GTI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

59729:CHMP6
gene id: 59729:CHMP6
uniprot id: H0YXU4
names: Similarity
messages: Belongs to the SNF7 family.

59729:BMP10
gene id: 59729:BMP10
uniprot id: A0A674HRA8
names: Similarity
messages: Belongs to the TGF-beta family.

59729:KEG28 p02
gene id: 59729:KEG28_p02
uniprot id: Q6RUP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

59729:LOC100229427
gene id: 59729:LOC100229427
uniprot id: H0ZKJ1
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

59729:ADSS2
gene id: 59729:ADSS2
uniprot id: A0A674HAV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

59729:IL18R1
gene id: 59729:IL18R1
uniprot id: A0A674GLC5
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

59729:SEC13
gene id: 59729:SEC13
uniprot id: H0ZJL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane
messages: nuclear pore complex

59729:APLP2
gene id: 59729:APLP2
uniprot id: H0YQL6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:DKK3
gene id: 59729:DKK3
uniprot id: B5FYS7
names: Similarity
messages: Belongs to the dickkopf family.

59729:GDAP1L1
gene id: 59729:GDAP1L1
uniprot id: H0Z4I8
names: Similarity
messages: Belongs to the GST superfamily.

59729:LOC100190105
gene id: 59729:LOC100190105
uniprot id: B5FY49
names: Similarity
messages: Belongs to the peptidase S51 family.

59729:CEL
gene id: 59729:CEL
uniprot id: H0Z4H9
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

59729:ATP8A1
gene id: 59729:ATP8A1
uniprot id: A0A674GH95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

59729:MMP2
gene id: 59729:MMP2
uniprot id: H0ZAJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: extracellular matrix

59729:CTNNA2
gene id: 59729:CTNNA2
uniprot id: H0ZKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus
messages: adherens junction
messages: axon
messages: cytoskeleton

59729:PPP2R5C
gene id: 59729:PPP2R5C
uniprot id: H0ZRC7
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

59729:SLC17A8
gene id: 59729:SLC17A8
uniprot id: H0ZF76
names: Subcellular Location Annotation
messages: Membrane

59729:GPX4
gene id: 59729:GPX4
uniprot id: B5G1Z5
names: Similarity
messages: Belongs to the glutathione peroxidase family.

59729:PYCR1
gene id: 59729:PYCR1
uniprot id: B5FZ50
uniprot id: H0YZE9
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

59729:LOC100219261
gene id: 59729:LOC100219261
uniprot id: B5FZH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

59729:CALHM5
gene id: 59729:CALHM5
uniprot id: H0ZNX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

59729:FOS
gene id: 59729:FOS
uniprot id: A0A674H3J9
names: Similarity
messages: Belongs to the bZIP family. Fos subfamily.

59729:PARP8
gene id: 59729:PARP8
uniprot id: A0A674G9U9
names: Similarity
messages: Belongs to the ARTD/PARP family.

59729:KCNK2
gene id: 59729:KCNK2
uniprot id: A0A674H2Z8
uniprot id: A0A674HAW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

59729:AACS
gene id: 59729:AACS
uniprot id: H0Z3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

59729:POLR2C
gene id: 59729:POLR2C
uniprot id: B5FZ64
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

59729:CSTF2
gene id: 59729:CSTF2
uniprot id: A0A674G7F3
uniprot id: A0A674GKM5
uniprot id: A0A674H008
names: Subcellular Location Annotation
messages: Nucleus

59729:NR1H3
gene id: 59729:NR1H3
uniprot id: A0A674GLK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

59729:COQ9
gene id: 59729:COQ9
uniprot id: B5FZ62
uniprot id: H0Z3N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

59729:LOC105758849
gene id: 59729:LOC105758849
uniprot id: H1A5Q2
names: Similarity
names: Subunit
messages: Belongs to the avian keratin family.
messages: The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides.

59729:BDNF
gene id: 59729:BDNF
uniprot id: A0A674GHV5
uniprot id: Q4JHT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
messages: Secreted

59729:VT1
gene id: 59729:VT1
uniprot id: H0Z5C4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:VTI1A
gene id: 59729:VTI1A
uniprot id: A0A674GDA7
uniprot id: A0A674H3P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

59729:LOC100223312
gene id: 59729:LOC100223312
uniprot id: H0YQL7
names: Subcellular Location Annotation
messages: Secreted

59729:DCN
gene id: 59729:DCN
uniprot id: A0A674GNM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.
messages: May affect the rate of fibrils formation.
messages: extracellular matrix

59729:PITHD1
gene id: 59729:PITHD1
uniprot id: B5FYE5
names: Similarity
messages: Belongs to the PITHD1 family.

59729:SKAP2
gene id: 59729:SKAP2
uniprot id: H0YXF4
names: Similarity
messages: Belongs to the SKAP family.

59729:ARPC4
gene id: 59729:ARPC4
uniprot id: B5FYW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Cell projection
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: cytoskeleton

59729:IL15
gene id: 59729:IL15
uniprot id: H0YVW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

59729:KEG28 p07
gene id: 59729:KEG28_p07
uniprot id: Q27GW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

59729:POU6F2
gene id: 59729:POU6F2
uniprot id: H0YUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

59729:LOC100190084
gene id: 59729:LOC100190084
uniprot id: B5FXY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

59729:RFX3
gene id: 59729:RFX3
uniprot id: A0A674HN21
uniprot id: H0Z4H7
names: Subcellular Location Annotation
messages: Nucleus

59729:RNASET2
gene id: 59729:RNASET2
uniprot id: A0A674GW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Lysosome lumen

59729:FZD7
gene id: 59729:FZD7
uniprot id: H0ZIP9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Cell membrane
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

59729:ATP6V1F
gene id: 59729:ATP6V1F
uniprot id: B5G4A4
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

59729:ANTKMT
gene id: 59729:ANTKMT
uniprot id: B5G043
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

59729:RPL7
gene id: 59729:RPL7
uniprot id: B5G3W2
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

59729:NINJ1
gene id: 59729:NINJ1
uniprot id: B5FYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

59729:SIX2
gene id: 59729:SIX2
uniprot id: H0Z093
names: Subcellular Location Annotation
messages: Nucleus

59729:IPO5
gene id: 59729:IPO5
uniprot id: A0A674GMR7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

59729:TBC1D24
gene id: 59729:TBC1D24
uniprot id: A0A674H1J1
uniprot id: A0A674HF88
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Interacts with ARF6.
messages: Membrane
messages: Presynapse
messages: Synapse

59729:VWF
gene id: 59729:VWF
uniprot id: F5XVC4
names: Subcellular Location Annotation
names: Subunit
messages: Multimeric. Interacts with F8.
messages: extracellular matrix

59729:ADRA1D
gene id: 59729:ADRA1D
uniprot id: A0A674GXD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

59729:PITX3
gene id: 59729:PITX3
uniprot id: H0ZAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

59729:THY1
gene id: 59729:THY1
uniprot id: B5G3M1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
messages: Membrane

59729:TXNL4B
gene id: 59729:TXNL4B
uniprot id: A0A674H6E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

59729:LOC105758723
gene id: 59729:LOC105758723
uniprot id: H0ZDM6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

59729:LOC100190137
gene id: 59729:LOC100190137
uniprot id: B5FYB8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

59729:MAP1LC3A
gene id: 59729:MAP1LC3A
uniprot id: B5FXD8
names: Similarity
messages: Belongs to the ATG8 family.

59729:PPP2R2C
gene id: 59729:PPP2R2C
uniprot id: A0A674GGR1
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

59729:UTS2
gene id: 59729:UTS2
uniprot id: A0A385LVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

59729:LOC100217958
gene id: 59729:LOC100217958
uniprot id: A0A674GG33
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

59729:LIN54
gene id: 59729:LIN54
uniprot id: A0A674GTM4
uniprot id: A0A674HJF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

59729:TOMM20
gene id: 59729:TOMM20
uniprot id: B5FY80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

59729:LOC100190592
gene id: 59729:LOC100190592
uniprot id: B5KFR9
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

59729:SGK1
gene id: 59729:SGK1
uniprot id: A0A674HCA5
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:FER
gene id: 59729:FER
uniprot id: A0A674HLR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: cytoskeleton

59729:HIBADH
gene id: 59729:HIBADH
uniprot id: A0A674HB90
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

59729:LOC100224299
gene id: 59729:LOC100224299
uniprot id: H0YP39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

59729:MAEA
gene id: 59729:MAEA
uniprot id: A0A674HJY4
uniprot id: B5FY55
names: Subcellular Location Annotation
messages: Nucleus matrix

59729:MTUS1
gene id: 59729:MTUS1
uniprot id: A0A674HMM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTUS1 family.
messages: Nucleus

59729:GRPEL2
gene id: 59729:GRPEL2
uniprot id: A0A674HRK7
names: Similarity
messages: Belongs to the GrpE family.

59729:SERINC1
gene id: 59729:SERINC1
uniprot id: H0ZNL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

59729:NDUFB8
gene id: 59729:NDUFB8
uniprot id: B5G3W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:AQP3
gene id: 59729:AQP3
uniprot id: H0YTV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

59729:MTM1
gene id: 59729:MTM1
uniprot id: A0A674H098
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cell membrane
messages: Late endosome
messages: filopodium
messages: ruffle
messages: sarcomere

59729:RBM22
gene id: 59729:RBM22
uniprot id: H0YRG9
names: Similarity
messages: Belongs to the SLT11 family.

59729:MPPE1
gene id: 59729:MPPE1
uniprot id: H0ZHD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallophosphoesterase superfamily. MPPE1 family.
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
messages: cis-Golgi network membrane

59729:TRAPPC2L
gene id: 59729:TRAPPC2L
uniprot id: B5FXJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: perinuclear region

59729:LOC100190505
gene id: 59729:LOC100190505
uniprot id: A0A674GU45
uniprot id: B5G3Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

59729:NDE1
gene id: 59729:NDE1
uniprot id: H0Z4N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: spindle

59729:LYRM1
gene id: 59729:LYRM1
uniprot id: B5FYC7
names: Similarity
messages: Belongs to the complex I LYR family.

59729:PSMC3IP
gene id: 59729:PSMC3IP
uniprot id: B5FZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

59729:ABLIM2
gene id: 59729:ABLIM2
uniprot id: A0A674GNN9
names: Subcellular Location Annotation
messages: Cytoplasm

59729:ACOX2
gene id: 59729:ACOX2
uniprot id: H0ZG19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

59729:ATP5PO
gene id: 59729:ATP5PO
uniprot id: B5G4C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

59729:ESF1
gene id: 59729:ESF1
uniprot id: H0YW48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

59729:NDUFC2
gene id: 59729:NDUFC2
uniprot id: B5FXS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

59729:ORAI2
gene id: 59729:ORAI2
uniprot id: A0A674GJE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

59729:SGMS2
gene id: 59729:SGMS2
uniprot id: H0Z0K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

59729:HMCES
gene id: 59729:HMCES
uniprot id: H0ZBV0
names: Function
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.
messages: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction.

59729:LOC100223260
gene id: 59729:LOC100223260
uniprot id: H0YSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:KARS1
gene id: 59729:KARS1
uniprot id: A0A674H7G9
uniprot id: H0ZDN2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

59729:HOMER1
gene id: 59729:HOMER1
uniprot id: H0YZU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

59729:ATP5PD
gene id: 59729:ATP5PD
uniprot id: B5G0V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

59729:MRPS25
gene id: 59729:MRPS25
uniprot id: B5G277
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS25 family.
messages: Mitochondrion

59729:LOC100218414
gene id: 59729:LOC100218414
uniprot id: H0YYI1
names: Subcellular Location Annotation
messages: Nucleus

59729:MRPS18A
gene id: 59729:MRPS18A
uniprot id: B5FZU4
names: Subcellular Location Annotation
messages: Mitochondrion

59729:COPS5
gene id: 59729:COPS5
uniprot id: B5FYR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: synaptic vesicle

59729:LRRC8A
gene id: 59729:LRRC8A
uniprot id: A0A674GWT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

59729:PACC1
gene id: 59729:PACC1
uniprot id: A0A674GZW6
uniprot id: H0YXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

59729:TCEA3
gene id: 59729:TCEA3
uniprot id: H0YRP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

59729:TVP23A
gene id: 59729:TVP23A
uniprot id: B5G137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Membrane

59729:GPR18
gene id: 59729:GPR18
uniprot id: H1A584
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane

59729:BCR
gene id: 59729:BCR
uniprot id: A0A674GR37
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

59729:USP15
gene id: 59729:USP15
uniprot id: A0A674H961
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Nucleus

59729:USP44
gene id: 59729:USP44
uniprot id: A0A674GD34
names: Similarity
messages: Belongs to the peptidase C19 family.

59729:RAB33B
gene id: 59729:RAB33B
uniprot id: A0A674H5L7
names: Similarity
messages: Belongs to the small GTPase superfamily. Rab family.

59729:TCEA1
gene id: 59729:TCEA1
uniprot id: A0A674H0E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
messages: Nucleus

59729:LYZ
gene id: 59729:LYZ
uniprot id: B5KFT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Secreted

59729:NLGN1
gene id: 59729:NLGN1
uniprot id: A0A674G931
uniprot id: A0A674HJX5
uniprot id: A0A674HQA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Cell membrane
messages: Membrane

59729:TUBB6
gene id: 59729:TUBB6
uniprot id: A0A674GUH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

59729:SYPL1
gene id: 59729:SYPL1
uniprot id: H0YXV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

59729:SNRPC
gene id: 59729:SNRPC
uniprot id: H0YU62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

59729:DLGAP2
gene id: 59729:DLGAP2
uniprot id: A0A674GQ00
names: Similarity
messages: Belongs to the SAPAP family.

59729:ORC4
gene id: 59729:ORC4
uniprot id: A0A674GGH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

59729:SYNDIG1
gene id: 59729:SYNDIG1
uniprot id: H0Z6M1
names: Similarity
messages: Belongs to the CD225/Dispanin family.

59729:SPTBN1
gene id: 59729:SPTBN1
uniprot id: A0A674GV67
names: Similarity
messages: Belongs to the spectrin family.

59729:GGPS1
gene id: 59729:GGPS1
uniprot id: A0A674HVI1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

59729:DHCR7
gene id: 59729:DHCR7
uniprot id: A0A674GDI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

59729:LCMT1
gene id: 59729:LCMT1
uniprot id: H0Z764
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

59729:DYNLRB1
gene id: 59729:DYNLRB1
uniprot id: B5FZN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: cytoskeleton

59729:SMYD2
gene id: 59729:SMYD2
uniprot id: H0YXN3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

59729:MC4R
gene id: 59729:MC4R
uniprot id: A0A674GHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

59729:SETD3
gene id: 59729:SETD3
uniprot id: A0A674GWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm

59729:DLC1
gene id: 59729:DLC1
uniprot id: H0ZAI1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
messages: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.
messages: Membrane
messages: focal adhesion

59729:TSPAN8
gene id: 59729:TSPAN8
uniprot id: H0Z9X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

59729:LOC100220017
gene id: 59729:LOC100220017
uniprot id: A0A674HDM8
names: Similarity
messages: Belongs to the splicing factor SR family.

59729:LOC101233192
gene id: 59729:LOC101233192
uniprot id: H0Z5X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

59729:CEBPZ
gene id: 59729:CEBPZ
uniprot id: H0ZE57
names: Similarity
messages: Belongs to the CBF/MAK21 family.

59729:WDFY2
gene id: 59729:WDFY2
uniprot id: A0A674GMQ3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

59729:LOC100230612
gene id: 59729:LOC100230612
uniprot id: A0A674GJB7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

59729:CAB39L
gene id: 59729:CAB39L
uniprot id: H0ZPJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

59729:SMIM8
gene id: 59729:SMIM8
uniprot id: H0ZQE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

59729:ANAPC2
gene id: 59729:ANAPC2
uniprot id: A0A674GLH7
names: Similarity
messages: Belongs to the cullin family.

59729:FOXL2
gene id: 59729:FOXL2
uniprot id: H0Z4D3
names: Subcellular Location Annotation
messages: Nucleus

59729:PJVK
gene id: 59729:PJVK
uniprot id: H0ZFV2
names: Similarity
messages: Belongs to the gasdermin family.

59729:LIMK2
gene id: 59729:LIMK2
uniprot id: H0ZHI5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

59729:EIF5
gene id: 59729:EIF5
uniprot id: H0ZRI5
names: Function
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

59729:ITGAV
gene id: 59729:ITGAV
uniprot id: H0ZLJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

59729:NGF
gene id: 59729:NGF
uniprot id: H0YRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Secreted

59729:KLHL40
gene id: 59729:KLHL40
uniprot id: H0YPS4
names: Similarity
names: Subcellular Location Annotation
messages: A band
messages: Belongs to the KLHL40 family.
messages: I band

59729:HOXB8
gene id: 59729:HOXB8
uniprot id: H0YZ13
names: Subcellular Location Annotation
messages: Nucleus

59729:GABARAPL2
gene id: 59729:GABARAPL2
uniprot id: B5G1P2
names: Similarity
messages: Belongs to the ATG8 family.

59729:IDH3A
gene id: 59729:IDH3A
uniprot id: B5FZM6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

59729:NDUFAF2
gene id: 59729:NDUFAF2
uniprot id: H0YWW4
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

59729:MAGI3
gene id: 59729:MAGI3
uniprot id: A0A674GHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane
messages: tight junction

59729:NOP58
gene id: 59729:NOP58
uniprot id: H0ZIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

59729:MAB21L2
gene id: 59729:MAB21L2
uniprot id: H0YWF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mab-21 family.
messages: Cytoplasm
messages: Nucleus

59729:SLC25A48
gene id: 59729:SLC25A48
uniprot id: H0YSM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

59729:LOC100230278
gene id: 59729:LOC100230278
uniprot id: A0A674GYD0
names: Similarity
messages: Belongs to the intermediate filament family.

59729:KCNMB1
gene id: 59729:KCNMB1
uniprot id: A0A674HHC2
names: Subcellular Location Annotation
messages: Membrane

59729:SYT17
gene id: 59729:SYT17
uniprot id: H0ZGL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Membrane

59729:LOC100229276
gene id: 59729:LOC100229276
uniprot id: B5FYW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:MRPL33
gene id: 59729:MRPL33
uniprot id: B5FZ89
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

59729:ARPC1A
gene id: 59729:ARPC1A
uniprot id: H0ZB85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: Nucleus
messages: cytoskeleton

59729:LOC100190610
gene id: 59729:LOC100190610
uniprot id: B5G2X9
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

59729:CALB2
gene id: 59729:CALB2
uniprot id: B5FYS1
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

59729:BBS2
gene id: 59729:BBS2
uniprot id: H0Z855
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

59729:SRP14
gene id: 59729:SRP14
uniprot id: B5FYF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm
messages: Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.

59729:FLCN
gene id: 59729:FLCN
uniprot id: A0A674GGP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

59729:STX16
gene id: 59729:STX16
uniprot id: A0A674GIK0
names: Similarity
messages: Belongs to the syntaxin family.

59729:LOC101234123
gene id: 59729:LOC101234123
uniprot id: A0A674GYA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

59729:C1H11orf54
gene id: 59729:C1H11orf54
uniprot id: H0ZRI8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.
messages: Monomer.
messages: Nucleus

59729:TP53RK
gene id: 59729:TP53RK
uniprot id: B5G025
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

59729:ERG28
gene id: 59729:ERG28
uniprot id: B5G3Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:NDUFA5
gene id: 59729:NDUFA5
uniprot id: B5FYU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

59729:C4H20orf27
gene id: 59729:C4H20orf27
uniprot id: B5FX50
names: Similarity
messages: Belongs to the UPF0687 family.

59729:ALDOB
gene id: 59729:ALDOB
uniprot id: H0YQW0
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

59729:LOC100220663
gene id: 59729:LOC100220663
uniprot id: B5G139
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MOZART2 family.
messages: centrosome
messages: spindle

59729:NKX6-3
gene id: 59729:NKX6-3
uniprot id: H0Z4B1
names: Subcellular Location Annotation
messages: Nucleus

59729:SLC25A5
gene id: 59729:SLC25A5
uniprot id: B5FYE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Monomer.

59729:TNFRSF1A
gene id: 59729:TNFRSF1A
uniprot id: H0ZT16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:MFAP3L
gene id: 59729:MFAP3L
uniprot id: A0A674H8T8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

59729:FGF6
gene id: 59729:FGF6
uniprot id: H0ZPU7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

59729:EPN2
gene id: 59729:EPN2
uniprot id: A0A674GLN6
uniprot id: H0Z9I7
names: Similarity
messages: Belongs to the epsin family.

59729:PRIM2
gene id: 59729:PRIM2
uniprot id: H0ZRC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.

59729:MTNR1A
gene id: 59729:MTNR1A
uniprot id: Q0ZAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

59729:C5H11orf49
gene id: 59729:C5H11orf49
uniprot id: A0A674GLT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: centriolar satellite

59729:LOC101234126
gene id: 59729:LOC101234126
uniprot id: H1A1X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Secreted

59729:WNT7B
gene id: 59729:WNT7B
uniprot id: A0A674HNV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

59729:CENPN
gene id: 59729:CENPN
uniprot id: H0Z2C2
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

59729:PRKX
gene id: 59729:PRKX
uniprot id: H0ZE73
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:TRAPPC4
gene id: 59729:TRAPPC4
uniprot id: H0YP37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

59729:INTS7
gene id: 59729:INTS7
uniprot id: H0YY53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Integrator subunit 7 family.
messages: Nucleus

59729:DPH5
gene id: 59729:DPH5
uniprot id: H0Z3P0
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

59729:MRPS27
gene id: 59729:MRPS27
uniprot id: A0A674H958
names: Subcellular Location Annotation
messages: Mitochondrion

59729:TOB1
gene id: 59729:TOB1
uniprot id: H0ZG06
names: Similarity
messages: Belongs to the BTG family.

59729:ATP5F1C
gene id: 59729:ATP5F1C
uniprot id: B5G252
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

59729:CNTNAP2
gene id: 59729:CNTNAP2
uniprot id: D8WUA6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: paranodal septate junction

59729:ENY2
gene id: 59729:ENY2
uniprot id: B5FZ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates in a subcomplex of SAGA called the DUB module (deubiquitination module) (By similarity).
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
messages: nucleoplasm

59729:UFD1
gene id: 59729:UFD1
uniprot id: H0ZDX0
names: Similarity
messages: Belongs to the UFD1 family.

59729:BIVM
gene id: 59729:BIVM
uniprot id: A0A674H993
names: Similarity
messages: Belongs to the BIVM family.

59729:COX7A2
gene id: 59729:COX7A2
uniprot id: B5FXU7
uniprot id: B5FXU8
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

59729:KCTD20
gene id: 59729:KCTD20
uniprot id: A0A674G8X3
names: Subcellular Location Annotation
messages: Cytoplasm

59729:ATP6V1G1
gene id: 59729:ATP6V1G1
uniprot id: B5G3I3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

59729:LOC100221285
gene id: 59729:LOC100221285
uniprot id: H0ZGH6
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

59729:MED30
gene id: 59729:MED30
uniprot id: B5FY99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 30 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

59729:PGS1
gene id: 59729:PGS1
uniprot id: H0YYR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

59729:DDX17
gene id: 59729:DDX17
uniprot id: H0ZJG0
names: Similarity
messages: Belongs to the DEAD box helicase family.

59729:SLC1A7
gene id: 59729:SLC1A7
uniprot id: A0A674HI47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

59729:SERF1A
gene id: 59729:SERF1A
uniprot id: B5G2W3
names: Similarity
messages: Belongs to the SERF family.

59729:FBLN7
gene id: 59729:FBLN7
uniprot id: H0ZAS7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

59729:SEMA3C
gene id: 59729:SEMA3C
uniprot id: A0A674GDI4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

59729:CFAP36
gene id: 59729:CFAP36
uniprot id: A0A674H2X7
names: Similarity
messages: Belongs to the CFAP36 family.

59729:DNAL4
gene id: 59729:DNAL4
uniprot id: A0A674GA88
uniprot id: B5G3W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

59729:LOC100228872
gene id: 59729:LOC100228872
uniprot id: H0ZA72
names: Similarity
messages: Belongs to the cytochrome P450 family.

59729:RRN3
gene id: 59729:RRN3
uniprot id: A0A674HS41
names: Similarity
messages: Belongs to the RRN3 family.

59729:WNT8A
gene id: 59729:WNT8A
uniprot id: H0YSE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

59729:NDST2
gene id: 59729:NDST2
uniprot id: A0A674GC42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

59729:SLC22A4
gene id: 59729:SLC22A4
uniprot id: A0A674H847
names: Similarity
names: Subunit
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

59729:B3GALT2
gene id: 59729:B3GALT2
uniprot id: A0A674HQQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

59729:RPL24
gene id: 59729:RPL24
uniprot id: B5FYC4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

59729:TM9SF2
gene id: 59729:TM9SF2
uniprot id: H0ZL20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

59729:ST6GAL2
gene id: 59729:ST6GAL2
uniprot id: A0A674HAN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

59729:TIMM17A
gene id: 59729:TIMM17A
uniprot id: B5G2C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

59729:P2RY8
gene id: 59729:P2RY8
uniprot id: H0ZKD3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:SHOX
gene id: 59729:SHOX
uniprot id: H0ZKA4
names: Subcellular Location Annotation
messages: Nucleus

59729:EPHX1
gene id: 59729:EPHX1
uniprot id: H0Z131
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

59729:SOD2
gene id: 59729:SOD2
uniprot id: B5G0D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

59729:PIN4
gene id: 59729:PIN4
uniprot id: B5KFL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
messages: Cytoplasm
messages: May be involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to DNA (By similarity).
messages: nucleolus
messages: spindle

59729:CACNG2
gene id: 59729:CACNG2
uniprot id: H0ZKD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

59729:EMC7
gene id: 59729:EMC7
uniprot id: B5FZG9
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

59729:MRPL27
gene id: 59729:MRPL27
uniprot id: H0ZF26
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

59729:RBM47
gene id: 59729:RBM47
uniprot id: H0ZEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM47 family.
messages: Nucleus

59729:NDUFS5
gene id: 59729:NDUFS5
uniprot id: B5G0Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

59729:FAM133B
gene id: 59729:FAM133B
uniprot id: B5G0R6
names: Similarity
messages: Belongs to the FAM133 family.

59729:CLCN3
gene id: 59729:CLCN3
uniprot id: H0Z719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

59729:EED
gene id: 59729:EED
uniprot id: H0ZRX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ESC family.
messages: Nucleus

59729:TPM4
gene id: 59729:TPM4
uniprot id: B5FYX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

59729:CCND1
gene id: 59729:CCND1
uniprot id: H0Z4M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclin family. Cyclin D subfamily.
messages: Cytoplasm
messages: Nucleus

59729:LOC100221884
gene id: 59729:LOC100221884
uniprot id: A0A674G968
names: Similarity
messages: Belongs to the DeSI family.

59729:SYT1
gene id: 59729:SYT1
uniprot id: Q2XQH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: Membrane
messages: chromaffin granule membrane
messages: synaptic vesicle membrane

59729:COX7C
gene id: 59729:COX7C
uniprot id: B5FZB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

59729:MCTS1
gene id: 59729:MCTS1
uniprot id: B5FXH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

59729:DUS4L
gene id: 59729:DUS4L
uniprot id: H0YY40
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

59729:TTR
gene id: 59729:TTR
uniprot id: B5G260
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

59729:ATP5MG
gene id: 59729:ATP5MG
uniprot id: B5G3Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

59729:IL12B
gene id: 59729:IL12B
uniprot id: H0YPL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

59729:RPS6KB1
gene id: 59729:RPS6KB1
uniprot id: H0ZBF2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

59729:FGF20
gene id: 59729:FGF20
uniprot id: H0ZAB7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

59729:HSPD1
gene id: 59729:HSPD1
uniprot id: H0ZJV4
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

59729:CREB1
gene id: 59729:CREB1
uniprot id: Q9W618
names: Subcellular Location Annotation
messages: Nucleus

59729:LOC100225385
gene id: 59729:LOC100225385
uniprot id: H0ZFM3
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

59729:ANXA4
gene id: 59729:ANXA4
uniprot id: B5FXE8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

59729:EGFR
gene id: 59729:EGFR
uniprot id: H0YU95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
messages: Membrane

59729:EXT2
gene id: 59729:EXT2
uniprot id: A0A674HKN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane

59729:TMEM80
gene id: 59729:TMEM80
uniprot id: B5FYL5
names: Subcellular Location Annotation
messages: Membrane

59729:DYNC2LI1
gene id: 59729:DYNC2LI1
uniprot id: H0YZP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light intermediate chain family.
messages: centrosome
messages: cilium
messages: cilium axoneme
messages: cilium basal body

59729:TAF1B
gene id: 59729:TAF1B
uniprot id: H0ZS29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: nucleolus

59729:MAPRE1
gene id: 59729:MAPRE1
uniprot id: H0Z7M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: centrosome
messages: spindle pole

59729:NUDT12
gene id: 59729:NUDT12
uniprot id: H0YRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

59729:LOC100226437
gene id: 59729:LOC100226437
uniprot id: B5G1W9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

59729:GRPEL1
gene id: 59729:GRPEL1
uniprot id: B5FXT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

59729:POLR2K
gene id: 59729:POLR2K
uniprot id: B5FYP8
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

59729:LOC100222183
gene id: 59729:LOC100222183
uniprot id: D8FT02
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

59729:TEC
gene id: 59729:TEC
uniprot id: H0ZCS7
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

59729:LACC1
gene id: 59729:LACC1
uniprot id: H0ZQ31
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

59729:PTPN21
gene id: 59729:PTPN21
uniprot id: H0ZQ90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

59729:CNRIP1
gene id: 59729:CNRIP1
uniprot id: A0A674GVC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

59729:LSM4
gene id: 59729:LSM4
uniprot id: B5KFU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

59729:INSIG2
gene id: 59729:INSIG2
uniprot id: A0A674HPT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

59729:SLC35F4
gene id: 59729:SLC35F4
uniprot id: H0ZS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

59729:LOC100228336
gene id: 59729:LOC100228336
uniprot id: A0A674GRH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

59729:MANF
gene id: 59729:MANF
uniprot id: B5FZV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

59729:YIPF6
gene id: 59729:YIPF6
uniprot id: B5FZB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

59729:PKIB
gene id: 59729:PKIB
uniprot id: A0A674H8D2
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

59729:TP73
gene id: 59729:TP73
uniprot id: A0A674GMJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Found in a complex with p53/TP53 and CABLES1.
messages: Nucleus
messages: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

59729:ATP5F1A
gene id: 59729:ATP5F1A
uniprot id: H0YTM0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

59729:MC5R
gene id: 59729:MC5R
uniprot id: A0A674H3T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.

59729:SNAPIN
gene id: 59729:SNAPIN
uniprot id: B5G4H7
names: Similarity
messages: Belongs to the SNAPIN family.

59729:SVBP
gene id: 59729:SVBP
uniprot id: B5FZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVBP family.
messages: Cytoplasm
messages: Enhances the tyrosine carboxypeptidase activity of vash1 and vash2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of vash1 and vash2. May play a role in axon and excitatory synapse formation (By similarity).
messages: Secreted
messages: cytoskeleton

59729:LOC100227541
gene id: 59729:LOC100227541
uniprot id: H0ZT64
names: Function
names: Similarity
messages: Belongs to the apovitellenin family.
messages: Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.

59729:TOR1B
gene id: 59729:TOR1B
uniprot id: A0A674GJD6
uniprot id: H0Z1Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

59729:USP35
gene id: 59729:USP35
uniprot id: H0ZS03
names: Similarity
messages: Belongs to the peptidase C19 family.

59729:ACTR10
gene id: 59729:ACTR10
uniprot id: A0A674G9H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: cytoskeleton

59729:PAX5
gene id: 59729:PAX5
uniprot id: A0A674GVC1
uniprot id: A0A674HPM1
names: Subcellular Location Annotation
messages: Nucleus

59729:LOC100217789
gene id: 59729:LOC100217789
uniprot id: H0Z2B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Membrane

59729:RAB32
gene id: 59729:RAB32
uniprot id: H0ZKG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

59729:FAM241A
gene id: 59729:FAM241A
uniprot id: A0A674H8W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

59729:KCNJ6
gene id: 59729:KCNJ6
uniprot id: H0Z3J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
messages: Membrane

59729:P2RX1
gene id: 59729:P2RX1
uniprot id: H0ZZW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

59729:FTH1
gene id: 59729:FTH1
uniprot id: B5G472
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

59729:DUSP6
gene id: 59729:DUSP6
uniprot id: H0ZCI9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

59729:NEU4
gene id: 59729:NEU4
uniprot id: A0A674GVS9
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

59729:RHO
gene id: 59729:RHO
uniprot id: Q9IA36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

59729:IER3IP1
gene id: 59729:IER3IP1
uniprot id: B5FXY2
names: Similarity
messages: Belongs to the YOS1 family.

59729:CMC2
gene id: 59729:CMC2
uniprot id: B5FXK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: May be involved in cytochrome c oxidase biogenesis.
messages: Mitochondrion

59729:SUB1
gene id: 59729:SUB1
uniprot id: B5FYR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Nucleus

59729:COPS4
gene id: 59729:COPS4
uniprot id: H0YX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

59729:LOC100230245
gene id: 59729:LOC100230245
uniprot id: A0A674HT40
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

59729:LAMP1
gene id: 59729:LAMP1
uniprot id: H0ZFX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane

59729:C3H6orf58
gene id: 59729:C3H6orf58
uniprot id: H0ZND9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

59729:TMEM63C
gene id: 59729:TMEM63C
uniprot id: A0A674GHT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

59729:RND3
gene id: 59729:RND3
uniprot id: H0ZP24
names: Function
messages: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

59729:NMUR2
gene id: 59729:NMUR2
uniprot id: H0YR51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

59729:HMGN5
gene id: 59729:HMGN5
uniprot id: B5FY60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

59729:BRPF3
gene id: 59729:BRPF3
uniprot id: A0A674GSI4
names: Subcellular Location Annotation
messages: Nucleus

59729:HMGB3
gene id: 59729:HMGB3
uniprot id: A0A674GRJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

59729:LOC100230549
gene id: 59729:LOC100230549
uniprot id: H0Z9L0
names: Similarity
messages: Belongs to the PRORSD1 family.

59729:ANXA5
gene id: 59729:ANXA5
uniprot id: A0A674H3S5
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

59729:HINT1
gene id: 59729:HINT1
uniprot id: B5G2K2
names: Similarity
messages: Belongs to the HINT family.

59729:NIPSNAP1
gene id: 59729:NIPSNAP1
uniprot id: B5FXC1
names: Similarity
messages: Belongs to the NipSnap family.

59729:LOC100222320
gene id: 59729:LOC100222320
uniprot id: H1A2P8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

59729:NSMCE1
gene id: 59729:NSMCE1
uniprot id: B5FYL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

59729:LHFPL5
gene id: 59729:LHFPL5
uniprot id: B5FXX9
names: Subcellular Location Annotation
messages: Membrane

59729:MARVELD2
gene id: 59729:MARVELD2
uniprot id: H0YTJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

59729:SNTG1
gene id: 59729:SNTG1
uniprot id: H0ZKZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

59729:PRKAB2
gene id: 59729:PRKAB2
uniprot id: A0A674HGM8
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

59729:NSA2
gene id: 59729:NSA2
uniprot id: B5FXH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

59729:NXT2
gene id: 59729:NXT2
uniprot id: A0A674GSW1
uniprot id: A0A674HCV4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

59729:KIF20A
gene id: 59729:KIF20A
uniprot id: H0ZTX3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

59729:RNF146
gene id: 59729:RNF146
uniprot id: H0ZNF0
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

59729:PDCD4
gene id: 59729:PDCD4
uniprot id: H0ZZ88
names: Similarity
messages: Belongs to the PDCD4 family.

59729:FGF9
gene id: 59729:FGF9
uniprot id: A0A674GK86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Secreted

59729:MTFR1
gene id: 59729:MTFR1
uniprot id: A0A674GNV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

59729:LOC100232117
gene id: 59729:LOC100232117
uniprot id: H0ZH38
names: Similarity
messages: Belongs to the globin family.

59729:MOV10
gene id: 59729:MOV10
uniprot id: H1A4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

59729:SLC20A2
gene id: 59729:SLC20A2
uniprot id: A0A674HFQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.

59729:PDK1
gene id: 59729:PDK1
uniprot id: H0ZDY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

59729:CEP20
gene id: 59729:CEP20
uniprot id: A0A674HPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: cilium basal body

59729:TMTC4
gene id: 59729:TMTC4
uniprot id: H0ZKX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

59729:CACNG5
gene id: 59729:CACNG5
uniprot id: A0A674GRG1
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

59729:CCDC181
gene id: 59729:CCDC181
uniprot id: A0A674G8H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton
messages: flagellum

59729:FGFR1OP2
gene id: 59729:FGFR1OP2
uniprot id: H0ZPL7
names: Similarity
messages: Belongs to the SIKE family.

59729:APOD
gene id: 59729:APOD
uniprot id: A0A674H772
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

59729:SLC12A4
gene id: 59729:SLC12A4
uniprot id: H0ZA22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

59729:DPCD
gene id: 59729:DPCD
uniprot id: B5FXE0
names: Similarity
messages: Belongs to the DPCD family.

59729:LOC100190349
gene id: 59729:LOC100190349
uniprot id: B5G0N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

59729:ALDH1A3
gene id: 59729:ALDH1A3
uniprot id: H0ZF04
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

59729:CHUK
gene id: 59729:CHUK
uniprot id: H0Z2P4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

59729:RBM8A
gene id: 59729:RBM8A
uniprot id: B5FZD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

59729:LOC100225918
gene id: 59729:LOC100225918
uniprot id: K9J9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

59729:CDC37L1
gene id: 59729:CDC37L1
uniprot id: H0Z449
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

59729:IFITM10
gene id: 59729:IFITM10
uniprot id: H0ZGM3
names: Similarity
messages: Belongs to the CD225/Dispanin family.

59729:VPS29
gene id: 59729:VPS29
uniprot id: B5G2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

59729:PPP1CC
gene id: 59729:PPP1CC
uniprot id: B5KFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Cleavage furrow
messages: Cytoplasm
messages: Midbody

59729:CHST12
gene id: 59729:CHST12
uniprot id: H0ZCS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

59729:LPAR4
gene id: 59729:LPAR4
uniprot id: H0YWI6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:PRKCD
gene id: 59729:PRKCD
uniprot id: H0Z2C3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

59729:CYP11A1
gene id: 59729:CYP11A1
uniprot id: Q6GVK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
messages: Belongs to the cytochrome P450 family.
messages: Mitochondrion inner membrane

59729:ELOVL4
gene id: 59729:ELOVL4
uniprot id: A0A674GJ08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

59729:GJA1
gene id: 59729:GJA1
uniprot id: H0ZNN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

59729:PRKACB
gene id: 59729:PRKACB
uniprot id: A0A674HDN1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

59729:TEKT3
gene id: 59729:TEKT3
uniprot id: H0Z3R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

59729:NAA60
gene id: 59729:NAA60
uniprot id: H0Z146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA60 subfamily.
messages: Golgi apparatus membrane

59729:LAPTM4A
gene id: 59729:LAPTM4A
uniprot id: B5G1Q1
uniprot id: B5G1Q5
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

59729:RIMKLB
gene id: 59729:RIMKLB
uniprot id: H0ZSA7
names: Similarity
messages: Belongs to the RimK family.

59729:WNT2
gene id: 59729:WNT2
uniprot id: H0Z3P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

59729:LOC100220117
gene id: 59729:LOC100220117
uniprot id: A0A674H483
names: Similarity
messages: Belongs to the serpin family.

59729:JAK2
gene id: 59729:JAK2
uniprot id: H0Z3Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system
messages: Nucleus

59729:MRPL2
gene id: 59729:MRPL2
uniprot id: B5FYM2
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

59729:LRRC8D
gene id: 59729:LRRC8D
uniprot id: H0Z736
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

59729:ATP5ME
gene id: 59729:ATP5ME
uniprot id: B5FYN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

59729:LYPLAL1
gene id: 59729:LYPLAL1
uniprot id: H0YX80
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

59729:CHST10
gene id: 59729:CHST10
uniprot id: H0ZIF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

59729:PPIL3
gene id: 59729:PPIL3
uniprot id: H0ZJF1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

59729:AHSA1
gene id: 59729:AHSA1
uniprot id: B5FYT0
names: Similarity
messages: Belongs to the AHA1 family.

59729:PHPT1
gene id: 59729:PHPT1
uniprot id: B5FXN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the janus family.
messages: Cytoplasm
messages: Exhibits phosphohistidine phosphatase activity.
messages: Monomer.

59729:ONECUT1
gene id: 59729:ONECUT1
uniprot id: H0Z8B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUT homeobox family.
messages: Nucleus

59729:PDE6H
gene id: 59729:PDE6H
uniprot id: A0A674H0X6
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

59729:XPNPEP1
gene id: 59729:XPNPEP1
uniprot id: H0ZJX2
names: Similarity
messages: Belongs to the peptidase M24B family.

59729:DDRGK1
gene id: 59729:DDRGK1
uniprot id: H0ZL58
names: Similarity
messages: Belongs to the DDRGK1 family.

59729:MLEC
gene id: 59729:MLEC
uniprot id: B5FXH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:COX7B
gene id: 59729:COX7B
uniprot id: B5G416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

59729:TBK1
gene id: 59729:TBK1
uniprot id: H0Z7Z2
names: Subcellular Location Annotation
messages: Cytoplasm

59729:SRD5A2
gene id: 59729:SRD5A2
uniprot id: H0ZDP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Microsome membrane

59729:HMGN1
gene id: 59729:HMGN1
uniprot id: B5FZ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

59729:TLR4
gene id: 59729:TLR4
uniprot id: B6D4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

59729:CNR1
gene id: 59729:CNR1
uniprot id: P56971
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids (By similarity). Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues (By similarity). Regulates cellular respiration and energy production in response to cannabinoids (By similarity). Signaling typically involves reduction in cyclic AMP (By similarity).
messages: Mitochondrion outer membrane
messages: Palmitoylation at Cys-417 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.
messages: Presynapse
messages: axon

59729:HBAP
gene id: 59729:HBAP
uniprot id: H0Z1T1
names: Similarity
messages: Belongs to the globin family.

59729:CHMP2B
gene id: 59729:CHMP2B
uniprot id: H0ZTI7
names: Similarity
messages: Belongs to the SNF7 family.

59729:HMOX2
gene id: 59729:HMOX2
uniprot id: B5G0B5
names: Similarity
messages: Belongs to the heme oxygenase family.

59729:ATP6V1H
gene id: 59729:ATP6V1H
uniprot id: A0A674GW16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

59729:SCAMP2
gene id: 59729:SCAMP2
uniprot id: H0Z0I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

59729:MAP2K3
gene id: 59729:MAP2K3
uniprot id: A0A674HQ61
names: Similarity
messages: Belongs to the protein kinase superfamily.

59729:OTOP1
gene id: 59729:OTOP1
uniprot id: H0ZI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

59729:TBCA
gene id: 59729:TBCA
uniprot id: B5G0F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

59729:VKORC1L1
gene id: 59729:VKORC1L1
uniprot id: H0Z4C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

59729:FGG
gene id: 59729:FGG
uniprot id: H0Z4E6
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

59729:CCR4
gene id: 59729:CCR4
uniprot id: H1A5S3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

59729:RPS11
gene id: 59729:RPS11
uniprot id: B5FX82
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

59729:NTMT2
gene id: 59729:NTMT2
uniprot id: A0A674GDQ9
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

59729:KATNAL1
gene id: 59729:KATNAL1
uniprot id: A0A674GK57
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
messages: Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.
messages: Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
messages: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
messages: Cytoplasm
messages: Interacts with KATNB1 and KATNBL1.
messages: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.
messages: centrosome
messages: cytoskeleton
messages: spindle
messages: spindle pole

59729:POLR2H
gene id: 59729:POLR2H
uniprot id: B5FXF5
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.

59729:FAM168A
gene id: 59729:FAM168A
uniprot id: B5FX98
names: Similarity
messages: Belongs to the FAM168 family.

59729:LOC100219437
gene id: 59729:LOC100219437
uniprot id: A0A674GW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

59729:LOC100218724
gene id: 59729:LOC100218724
uniprot id: A0A674HAK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

59729:ADORA1
gene id: 59729:ADORA1
uniprot id: H0YT13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.