595494:TOLA RS09215
gene id: 595494:TOLA_RS09215
uniprot id: C4LFQ6
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

595494:TOLA RS00820
gene id: 595494:TOLA_RS00820
uniprot id: C4L7Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

595494:TOLA RS10925
gene id: 595494:TOLA_RS10925
uniprot id: C4L8A3
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

595494:TOLA RS10085
gene id: 595494:TOLA_RS10085
uniprot id: C4L7G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

595494:TOLA RS01235
gene id: 595494:TOLA_RS01235
uniprot id: C4L8J2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

595494:TOLA RS11955
gene id: 595494:TOLA_RS11955
uniprot id: C4L9J7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS00410
gene id: 595494:TOLA_RS00410
uniprot id: C4L7D1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

595494:TOLA RS08050
gene id: 595494:TOLA_RS08050
uniprot id: C4LF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

595494:TOLA RS00610
gene id: 595494:TOLA_RS00610
uniprot id: C4L7U8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

595494:TOLA RS08490
gene id: 595494:TOLA_RS08490
uniprot id: C4LFB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

595494:TOLA RS08035
gene id: 595494:TOLA_RS08035
uniprot id: C4LF21
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

595494:TOLA RS07295
gene id: 595494:TOLA_RS07295
uniprot id: C4LEM7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

595494:TOLA RS14960
gene id: 595494:TOLA_RS14960
uniprot id: C4LCK1
names: Similarity
messages: Belongs to the pirin family.

595494:TOLA RS00540
gene id: 595494:TOLA_RS00540
uniprot id: C4L7T4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

595494:TOLA RS13875
gene id: 595494:TOLA_RS13875
uniprot id: C4LBN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

595494:TOLA RS06915
gene id: 595494:TOLA_RS06915
uniprot id: C4LEF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

595494:TOLA RS12770
gene id: 595494:TOLA_RS12770
uniprot id: C4LAC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS07325
gene id: 595494:TOLA_RS07325
uniprot id: C4LEN3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

595494:TOLA RS10245
gene id: 595494:TOLA_RS10245
uniprot id: C4L7J8
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.

595494:TOLA RS10905
gene id: 595494:TOLA_RS10905
uniprot id: C4L899
names: Similarity
messages: Belongs to the FeoA family.

595494:TOLA RS00975
gene id: 595494:TOLA_RS00975
uniprot id: C4L814
names: Similarity
messages: Belongs to the UPF0758 family.

595494:TOLA RS05745
gene id: 595494:TOLA_RS05745
uniprot id: C4LDE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

595494:TOLA RS12235
gene id: 595494:TOLA_RS12235
uniprot id: C4L9P8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

595494:TOLA RS10140
gene id: 595494:TOLA_RS10140
uniprot id: C4L7H7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS12730
gene id: 595494:TOLA_RS12730
uniprot id: C4LAB9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

595494:TOLA RS07060
gene id: 595494:TOLA_RS07060
uniprot id: C4LEI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

595494:TOLA RS09310
gene id: 595494:TOLA_RS09310
uniprot id: C4LFS5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS05380
gene id: 595494:TOLA_RS05380
uniprot id: C4LCW0
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

595494:TOLA RS07995
gene id: 595494:TOLA_RS07995
uniprot id: C4LF13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

595494:TOLA RS05330
gene id: 595494:TOLA_RS05330
uniprot id: C4LCU9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS12010
gene id: 595494:TOLA_RS12010
uniprot id: C4L9K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

595494:TOLA RS04070
gene id: 595494:TOLA_RS04070
uniprot id: C4LBI8
names: Similarity
messages: Belongs to the UPF0234 family.

595494:TOLA RS02990
gene id: 595494:TOLA_RS02990
uniprot id: C4LAK4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS09105
gene id: 595494:TOLA_RS09105
uniprot id: C4LFN5
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS14980
gene id: 595494:TOLA_RS14980
uniprot id: C4LCK5
names: Similarity
messages: Belongs to the P(II) protein family.

595494:TOLA RS08765
gene id: 595494:TOLA_RS08765
uniprot id: C4LFG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

595494:TOLA RS11785
gene id: 595494:TOLA_RS11785
uniprot id: C4L945
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

595494:TOLA RS00480
gene id: 595494:TOLA_RS00480
uniprot id: C4L7S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14490
gene id: 595494:TOLA_RS14490
uniprot id: C4LCB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

595494:TOLA RS04535
gene id: 595494:TOLA_RS04535
uniprot id: C4LC33
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS09985
gene id: 595494:TOLA_RS09985
uniprot id: C4L7E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS07305
gene id: 595494:TOLA_RS07305
uniprot id: C4LEM9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

595494:TOLA RS04395
gene id: 595494:TOLA_RS04395
uniprot id: C4LC05
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

595494:TOLA RS00460
gene id: 595494:TOLA_RS00460
uniprot id: C4L7R8
names: Similarity
messages: Belongs to the PspA/IM30 family.

595494:TOLA RS09260
gene id: 595494:TOLA_RS09260
uniprot id: C4LFR5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

595494:TOLA RS10595
gene id: 595494:TOLA_RS10595
uniprot id: C4L838
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

595494:TOLA RS12585
gene id: 595494:TOLA_RS12585
uniprot id: C4LA93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

595494:TOLA RS13560
gene id: 595494:TOLA_RS13560
uniprot id: C4LB56
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

595494:TOLA RS07145
gene id: 595494:TOLA_RS07145
uniprot id: C4LEJ6
names: Similarity
messages: Belongs to the IMPACT family.

595494:TOLA RS10450
gene id: 595494:TOLA_RS10450
uniprot id: C4L7N9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

595494:TOLA RS13145
gene id: 595494:TOLA_RS13145
uniprot id: C4LAX6
names: Function
names: Similarity
messages: Belongs to the UxaA family.
messages: Catalyzes the dehydration of galactarate to form 5-dehydro-4-deoxy-D-glucarate (5-KDG).

595494:TOLA RS06775
gene id: 595494:TOLA_RS06775
uniprot id: C4LEC7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

595494:TOLA RS15860
gene id: 595494:TOLA_RS15860
uniprot id: C4LDR8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

595494:TOLA RS06580
gene id: 595494:TOLA_RS06580
uniprot id: C4LE84
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11865
gene id: 595494:TOLA_RS11865
uniprot id: C4L9H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS08535
gene id: 595494:TOLA_RS08535
uniprot id: C4LFC1
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

595494:TOLA RS02915
gene id: 595494:TOLA_RS02915
uniprot id: C4LA64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14810
gene id: 595494:TOLA_RS14810
uniprot id: C4LCH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

595494:TOLA RS13695
gene id: 595494:TOLA_RS13695
uniprot id: C4LB81
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

595494:TOLA RS10965
gene id: 595494:TOLA_RS10965
uniprot id: C4L8B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm

595494:TOLA RS01215
gene id: 595494:TOLA_RS01215
uniprot id: C4L8I8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

595494:TOLA RS11715
gene id: 595494:TOLA_RS11715
uniprot id: C4L936
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS15165
gene id: 595494:TOLA_RS15165
uniprot id: C4LD15
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

595494:TOLA RS00635
gene id: 595494:TOLA_RS00635
uniprot id: C4L7V3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

595494:TOLA RS10365
gene id: 595494:TOLA_RS10365
uniprot id: C4L7M2
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

595494:TOLA RS02255
gene id: 595494:TOLA_RS02255
uniprot id: C4L9G2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

595494:TOLA RS09015
gene id: 595494:TOLA_RS09015
uniprot id: C4LFL7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

595494:TOLA RS14935
gene id: 595494:TOLA_RS14935
uniprot id: C4LCJ6
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

595494:TOLA RS01625
gene id: 595494:TOLA_RS01625
uniprot id: C4L8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS02845
gene id: 595494:TOLA_RS02845
uniprot id: C4LA51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

595494:TOLA RS11095
gene id: 595494:TOLA_RS11095
uniprot id: C4L8D8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

595494:TOLA RS08345
gene id: 595494:TOLA_RS08345
uniprot id: C4LF83
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS09775
gene id: 595494:TOLA_RS09775
uniprot id: C4LG05
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

595494:TOLA RS14245
gene id: 595494:TOLA_RS14245
uniprot id: C4LBV1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

595494:TOLA RS05350
gene id: 595494:TOLA_RS05350
uniprot id: C4LCV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the rhamnose mutarotase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the anomeric conversion of L-rhamnose.

595494:TOLA RS07975
gene id: 595494:TOLA_RS07975
uniprot id: C4LF09
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

595494:TOLA RS10050
gene id: 595494:TOLA_RS10050
uniprot id: C4L7F9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS13715
gene id: 595494:TOLA_RS13715
uniprot id: C4LB85
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

595494:TOLA RS07160
gene id: 595494:TOLA_RS07160
uniprot id: C4LEJ9
names: Subcellular Location Annotation
messages: Cell inner membrane

595494:TOLA RS10995
gene id: 595494:TOLA_RS10995
uniprot id: C4L8B8
names: Similarity
messages: Belongs to the AAE transporter (TC 2.A.81) family.

595494:TOLA RS05620
gene id: 595494:TOLA_RS05620
uniprot id: C4LDC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

595494:TOLA RS10185
gene id: 595494:TOLA_RS10185
uniprot id: C4L7I6
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

595494:TOLA RS11650
gene id: 595494:TOLA_RS11650
uniprot id: C4L923
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

595494:TOLA RS15015
gene id: 595494:TOLA_RS15015
uniprot id: C4LCY5
names: Similarity
messages: Belongs to the BolA/IbaG family.

595494:TOLA RS01180
gene id: 595494:TOLA_RS01180
uniprot id: C4L8I1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

595494:TOLA RS00650
gene id: 595494:TOLA_RS00650
uniprot id: C4L7V6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

595494:TOLA RS12930
gene id: 595494:TOLA_RS12930
uniprot id: C4LAF9
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

595494:TOLA RS10250
gene id: 595494:TOLA_RS10250
uniprot id: C4L7J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity.

595494:TOLA RS02960
gene id: 595494:TOLA_RS02960
uniprot id: C4LA73
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS02555
gene id: 595494:TOLA_RS02555
uniprot id: C4L9Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS11255
gene id: 595494:TOLA_RS11255
uniprot id: C4L8U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

595494:TOLA RS00110
gene id: 595494:TOLA_RS00110
uniprot id: C4L776
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell inner membrane

595494:TOLA RS03410
gene id: 595494:TOLA_RS03410
uniprot id: C4LAT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.
messages: Homodimer.

595494:TOLA RS09115
gene id: 595494:TOLA_RS09115
uniprot id: C4LFN7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

595494:TOLA RS10475
gene id: 595494:TOLA_RS10475
uniprot id: C4L7P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS07640
gene id: 595494:TOLA_RS07640
uniprot id: C4LEU6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

595494:TOLA RS08785
gene id: 595494:TOLA_RS08785
uniprot id: C4LFH1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

595494:TOLA RS11475
gene id: 595494:TOLA_RS11475
uniprot id: C4L8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

595494:TOLA RS01990
gene id: 595494:TOLA_RS01990
uniprot id: C4L9A9
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

595494:TOLA RS07930
gene id: 595494:TOLA_RS07930
uniprot id: C4LEZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapA family.
messages: Cell inner membrane
messages: Involved in the assembly of lipopolysaccharide (LPS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS12505
gene id: 595494:TOLA_RS12505
uniprot id: C4LA77
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS04330
gene id: 595494:TOLA_RS04330
uniprot id: C4LBZ2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

595494:TOLA RS10105
gene id: 595494:TOLA_RS10105
uniprot id: C4L7H0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS02235
gene id: 595494:TOLA_RS02235
uniprot id: C4L9F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

595494:TOLA RS10640
gene id: 595494:TOLA_RS10640
uniprot id: C4L845
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

595494:TOLA RS05500
gene id: 595494:TOLA_RS05500
uniprot id: C4LDA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

595494:TOLA RS08260
gene id: 595494:TOLA_RS08260
uniprot id: C4LF66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

595494:TOLA RS03150
gene id: 595494:TOLA_RS03150
uniprot id: C4LAN6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

595494:TOLA RS14940
gene id: 595494:TOLA_RS14940
uniprot id: C4LCJ7
names: Similarity
messages: Belongs to the Fur family.

595494:TOLA RS07765
gene id: 595494:TOLA_RS07765
uniprot id: C4LEW9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

595494:TOLA RS07935
gene id: 595494:TOLA_RS07935
uniprot id: C4LF00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

595494:TOLA RS10530
gene id: 595494:TOLA_RS10530
uniprot id: C4L7Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

595494:TOLA RS08660
gene id: 595494:TOLA_RS08660
uniprot id: C4LFE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family. PduW subfamily.
messages: Cytoplasm
messages: Works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of 1,2-propanediol (1,2-PD).

595494:TOLA RS04305
gene id: 595494:TOLA_RS04305
uniprot id: C4LBY5
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11780
gene id: 595494:TOLA_RS11780
uniprot id: C4L944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

595494:TOLA RS04975
gene id: 595494:TOLA_RS04975
uniprot id: C4LCN1
names: Similarity
messages: Belongs to the GSP E family.

595494:TOLA RS15325
gene id: 595494:TOLA_RS15325
uniprot id: C4LD43
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS16235
gene id: 595494:TOLA_RS16235
uniprot id: C4LDZ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS01805
gene id: 595494:TOLA_RS01805
uniprot id: C4L972
names: Similarity
messages: Belongs to the VgrG protein family.

595494:TOLA RS07885
gene id: 595494:TOLA_RS07885
uniprot id: C4LEZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

595494:TOLA RS04310
gene id: 595494:TOLA_RS04310
uniprot id: C4LBY7
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02200
gene id: 595494:TOLA_RS02200
uniprot id: C4L9F1
names: Similarity
messages: Belongs to the HSP15 family.

595494:TOLA RS12965
gene id: 595494:TOLA_RS12965
uniprot id: C4LAG7
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS13035
gene id: 595494:TOLA_RS13035
uniprot id: C4LAI1
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

595494:TOLA RS06965
gene id: 595494:TOLA_RS06965
uniprot id: C4LEG2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS04720
gene id: 595494:TOLA_RS04720
uniprot id: C4LC68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

595494:TOLA RS11270
gene id: 595494:TOLA_RS11270
uniprot id: C4L8U8
names: Similarity
messages: Belongs to the UPF0319 family.

595494:TOLA RS04645
gene id: 595494:TOLA_RS04645
uniprot id: C4LC53
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

595494:TOLA RS01270
gene id: 595494:TOLA_RS01270
uniprot id: C4L8J9
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

595494:TOLA RS11880
gene id: 595494:TOLA_RS11880
uniprot id: C4L9I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter family.
messages: Membrane

595494:TOLA RS15070
gene id: 595494:TOLA_RS15070
uniprot id: C4LCZ6
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

595494:TOLA RS15935
gene id: 595494:TOLA_RS15935
uniprot id: C4LDT2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

595494:TOLA RS11335
gene id: 595494:TOLA_RS11335
uniprot id: C4L8W1
names: Similarity
messages: Belongs to the UPF0434 family.

595494:TOLA RS15705
gene id: 595494:TOLA_RS15705
uniprot id: C4LDN7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

595494:TOLA RS02735
gene id: 595494:TOLA_RS02735
uniprot id: C4LA28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

595494:TOLA RS04820
gene id: 595494:TOLA_RS04820
uniprot id: C4LC88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

595494:TOLA RS13015
gene id: 595494:TOLA_RS13015
uniprot id: C4LAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS06600
gene id: 595494:TOLA_RS06600
uniprot id: C4LE88
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

595494:TOLA RS12500
gene id: 595494:TOLA_RS12500
uniprot id: C4LA76
names: Similarity
messages: Belongs to the carbamate kinase family.

595494:TOLA RS02560
gene id: 595494:TOLA_RS02560
uniprot id: C4L9Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

595494:TOLA RS13670
gene id: 595494:TOLA_RS13670
uniprot id: C4LB76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS04810
gene id: 595494:TOLA_RS04810
uniprot id: C4LC86
names: Similarity
messages: Belongs to the YciI family.

595494:TOLA RS07910
gene id: 595494:TOLA_RS07910
uniprot id: C4LEZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

595494:TOLA RS08815
gene id: 595494:TOLA_RS08815
uniprot id: C4LFH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

595494:TOLA RS03495
gene id: 595494:TOLA_RS03495
uniprot id: C4LAV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

595494:TOLA RS00020
gene id: 595494:TOLA_RS00020
uniprot id: C4L758
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

595494:TOLA RS05625
gene id: 595494:TOLA_RS05625
uniprot id: C4LDC9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.

595494:TOLA RS10825
gene id: 595494:TOLA_RS10825
uniprot id: C4L883
names: Similarity
messages: Belongs to the YciI family.

595494:TOLA RS05220
gene id: 595494:TOLA_RS05220
uniprot id: C4LCS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS03360
gene id: 595494:TOLA_RS03360
uniprot id: C4LAS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

595494:TOLA RS11825
gene id: 595494:TOLA_RS11825
uniprot id: C4L953
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell inner membrane
messages: Cytoplasm

595494:TOLA RS09990
gene id: 595494:TOLA_RS09990
uniprot id: C4L7E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS06740
gene id: 595494:TOLA_RS06740
uniprot id: C4LEB6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS01620
gene id: 595494:TOLA_RS01620
uniprot id: C4L8R8
names: Similarity
messages: Belongs to the UPF0251 family.

595494:TOLA RS00155
gene id: 595494:TOLA_RS00155
uniprot id: C4L779
names: Similarity
messages: Belongs to the transposase 8 family.

595494:TOLA RS16115
gene id: 595494:TOLA_RS16115
uniprot id: C4LDW8
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

595494:TOLA RS01840
gene id: 595494:TOLA_RS01840
uniprot id: C4L979
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

595494:TOLA RS10080
gene id: 595494:TOLA_RS10080
uniprot id: C4L7G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

595494:TOLA RS06110
gene id: 595494:TOLA_RS06110
uniprot id: C4LDL9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS07255
gene id: 595494:TOLA_RS07255
uniprot id: C4LEL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

595494:TOLA RS06030
gene id: 595494:TOLA_RS06030
uniprot id: C4LDK5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

595494:TOLA RS10315
gene id: 595494:TOLA_RS10315
uniprot id: C4L7L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

595494:TOLA RS05340
gene id: 595494:TOLA_RS05340
uniprot id: C4LCV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

595494:TOLA RS15845
gene id: 595494:TOLA_RS15845
uniprot id: C4LDR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

595494:TOLA RS15870
gene id: 595494:TOLA_RS15870
uniprot id: C4LDS0
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

595494:TOLA RS14010
gene id: 595494:TOLA_RS14010
uniprot id: C4LBR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

595494:TOLA RS02360
gene id: 595494:TOLA_RS02360
uniprot id: C4L9V3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

595494:TOLA RS13830
gene id: 595494:TOLA_RS13830
uniprot id: C4LBM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS06555
gene id: 595494:TOLA_RS06555
uniprot id: C4LE79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

595494:TOLA RS10720
gene id: 595494:TOLA_RS10720
uniprot id: C4L861
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

595494:TOLA RS10240
gene id: 595494:TOLA_RS10240
uniprot id: C4L7J7
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

595494:TOLA RS11770
gene id: 595494:TOLA_RS11770
uniprot id: C4L942
names: Similarity
messages: Belongs to the AlaDH/PNT family.

595494:TOLA RS11330
gene id: 595494:TOLA_RS11330
uniprot id: C4L8W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

595494:TOLA RS06430
gene id: 595494:TOLA_RS06430
uniprot id: C4LE54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

595494:TOLA RS08570
gene id: 595494:TOLA_RS08570
uniprot id: C4LFC8
names: Subcellular Location Annotation
messages: Bacterial microcompartment

595494:TOLA RS07140
gene id: 595494:TOLA_RS07140
uniprot id: C4LEJ5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

595494:TOLA RS03515
gene id: 595494:TOLA_RS03515
uniprot id: C4LAV8
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

595494:TOLA RS12670
gene id: 595494:TOLA_RS12670
uniprot id: C4LAA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

595494:TOLA RS10375
gene id: 595494:TOLA_RS10375
uniprot id: C4L7M4
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

595494:TOLA RS06680
gene id: 595494:TOLA_RS06680
uniprot id: C4LEA4
names: Subunit
messages: Homodimer.

595494:TOLA RS11240
gene id: 595494:TOLA_RS11240
uniprot id: C4L8U3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

595494:TOLA RS04400
gene id: 595494:TOLA_RS04400
uniprot id: C4LC06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS07940
gene id: 595494:TOLA_RS07940
uniprot id: C4LF01
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

595494:TOLA RS11355
gene id: 595494:TOLA_RS11355
uniprot id: C4L8W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS00970
gene id: 595494:TOLA_RS00970
uniprot id: C4L813
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

595494:TOLA RS04360
gene id: 595494:TOLA_RS04360
uniprot id: C4LBZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

595494:TOLA RS15370
gene id: 595494:TOLA_RS15370
uniprot id: C4LD52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

595494:TOLA RS14570
gene id: 595494:TOLA_RS14570
uniprot id: C4LCD1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

595494:TOLA RS01300
gene id: 595494:TOLA_RS01300
uniprot id: C4L8K5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

595494:TOLA RS04365
gene id: 595494:TOLA_RS04365
uniprot id: C4LBZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS05705
gene id: 595494:TOLA_RS05705
uniprot id: C4LDE4
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.

595494:TOLA RS04335
gene id: 595494:TOLA_RS04335
uniprot id: C4LBZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

595494:TOLA RS11675
gene id: 595494:TOLA_RS11675
uniprot id: C4L928
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

595494:TOLA RS15985
gene id: 595494:TOLA_RS15985
uniprot id: C4LDU2
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

595494:TOLA RS09145
gene id: 595494:TOLA_RS09145
uniprot id: C4LFP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

595494:TOLA RS15180
gene id: 595494:TOLA_RS15180
uniprot id: C4LD18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

595494:TOLA RS02590
gene id: 595494:TOLA_RS02590
uniprot id: C4LA00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

595494:TOLA RS03100
gene id: 595494:TOLA_RS03100
uniprot id: C4LAM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

595494:TOLA RS06255
gene id: 595494:TOLA_RS06255
uniprot id: C4LE19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

595494:TOLA RS13475
gene id: 595494:TOLA_RS13475
uniprot id: C4LB39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

595494:TOLA RS16145
gene id: 595494:TOLA_RS16145
uniprot id: C4LDX5
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 104 family.
messages: Protein-arginine rhamnosyltransferase that catalyzes the transfer of a single rhamnose to elongation factor P (EF-P) on 'Lys-32', a modification required for EF-P-dependent rescue of polyproline stalled ribosomes.

595494:TOLA RS05360
gene id: 595494:TOLA_RS05360
uniprot id: C4LCV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rhamnose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
messages: Cytoplasm

595494:TOLA RS02720
gene id: 595494:TOLA_RS02720
uniprot id: C4LA25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

595494:TOLA RS06540
gene id: 595494:TOLA_RS06540
uniprot id: C4LE76
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10585
gene id: 595494:TOLA_RS10585
uniprot id: C4L836
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

595494:TOLA RS12625
gene id: 595494:TOLA_RS12625
uniprot id: C4LAA2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS05770
gene id: 595494:TOLA_RS05770
uniprot id: C4LDF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

595494:TOLA RS11745
gene id: 595494:TOLA_RS11745
uniprot id: C4L937
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

595494:TOLA RS08800
gene id: 595494:TOLA_RS08800
uniprot id: C4LFH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

595494:TOLA RS06290
gene id: 595494:TOLA_RS06290
uniprot id: C4LE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS13435
gene id: 595494:TOLA_RS13435
uniprot id: C4LB31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell inner membrane
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

595494:TOLA RS05825
gene id: 595494:TOLA_RS05825
uniprot id: C4LDG6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS07815
gene id: 595494:TOLA_RS07815
uniprot id: C4LEX9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS03190
gene id: 595494:TOLA_RS03190
uniprot id: C4LAP2
names: PTM
names: Subcellular Location Annotation
messages: Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.
messages: Cell inner membrane

595494:TOLA RS13170
gene id: 595494:TOLA_RS13170
uniprot id: C4LAY1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

595494:TOLA RS05175
gene id: 595494:TOLA_RS05175
uniprot id: C4LCR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS07565
gene id: 595494:TOLA_RS07565
uniprot id: C4LET1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homotetramer.

595494:TOLA RS00325
gene id: 595494:TOLA_RS00325
uniprot id: C4L7B3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

595494:TOLA RS13425
gene id: 595494:TOLA_RS13425
uniprot id: C4LB29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

595494:TOLA RS00825
gene id: 595494:TOLA_RS00825
uniprot id: C4L7Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

595494:TOLA RS04805
gene id: 595494:TOLA_RS04805
uniprot id: C4LC85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

595494:TOLA RS07990
gene id: 595494:TOLA_RS07990
uniprot id: C4LF12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

595494:TOLA RS02035
gene id: 595494:TOLA_RS02035
uniprot id: C4L9B8
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS04965
gene id: 595494:TOLA_RS04965
uniprot id: C4LCM9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

595494:TOLA RS14100
gene id: 595494:TOLA_RS14100
uniprot id: C4LBS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

595494:TOLA RS10660
gene id: 595494:TOLA_RS10660
uniprot id: C4L849
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS06165
gene id: 595494:TOLA_RS06165
uniprot id: C4LE02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS03155
gene id: 595494:TOLA_RS03155
uniprot id: C4LAN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

595494:TOLA RS04705
gene id: 595494:TOLA_RS04705
uniprot id: C4LC65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

595494:TOLA RS10255
gene id: 595494:TOLA_RS10255
uniprot id: C4L7K0
names: Similarity
messages: Belongs to the HesB/IscA family.

595494:TOLA RS08575
gene id: 595494:TOLA_RS08575
uniprot id: C4LFC9
names: Similarity
messages: Belongs to the diol/glycerol dehydratase large subunit family.

595494:TOLA RS13370
gene id: 595494:TOLA_RS13370
uniprot id: C4LB21
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

595494:TOLA RS01905
gene id: 595494:TOLA_RS01905
uniprot id: C4L992
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS04040
gene id: 595494:TOLA_RS04040
uniprot id: C4LBI2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS10760
gene id: 595494:TOLA_RS10760
uniprot id: C4L870
names: Similarity
messages: Belongs to the glycosyl hydrolase.

595494:TOLA RS14830
gene id: 595494:TOLA_RS14830
uniprot id: C4LCI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.
messages: Membrane

595494:TOLA RS07345
gene id: 595494:TOLA_RS07345
uniprot id: C4LEN7
names: Caution
names: Function
names: Similarity
messages: Belongs to the Dus family. DusC subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS03500
gene id: 595494:TOLA_RS03500
uniprot id: C4LAV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

595494:TOLA RS10985
gene id: 595494:TOLA_RS10985
uniprot id: C4L8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

595494:TOLA RS11365
gene id: 595494:TOLA_RS11365
uniprot id: C4L8W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

595494:TOLA RS05690
gene id: 595494:TOLA_RS05690
uniprot id: C4LDE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

595494:TOLA RS04210
gene id: 595494:TOLA_RS04210
uniprot id: C4LBL5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

595494:TOLA RS15000
gene id: 595494:TOLA_RS15000
uniprot id: C4LCK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

595494:TOLA RS05815
gene id: 595494:TOLA_RS05815
uniprot id: C4LDG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane

595494:TOLA RS15760
gene id: 595494:TOLA_RS15760
uniprot id: C4LDP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

595494:TOLA RS01480
gene id: 595494:TOLA_RS01480
uniprot id: C4L8P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

595494:TOLA RS13815
gene id: 595494:TOLA_RS13815
uniprot id: C4LBM6
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

595494:TOLA RS04140
gene id: 595494:TOLA_RS04140
uniprot id: C4LBK1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell inner membrane
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

595494:TOLA RS07825
gene id: 595494:TOLA_RS07825
uniprot id: C4LEY1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

595494:TOLA RS11975
gene id: 595494:TOLA_RS11975
uniprot id: C4L9K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS05650
gene id: 595494:TOLA_RS05650
uniprot id: C4LDD4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS00220
gene id: 595494:TOLA_RS00220
uniprot id: C4L792
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

595494:TOLA RS07190
gene id: 595494:TOLA_RS07190
uniprot id: C4LEK5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

595494:TOLA RS00505
gene id: 595494:TOLA_RS00505
uniprot id: C4L7S7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

595494:TOLA RS04440
gene id: 595494:TOLA_RS04440
uniprot id: C4LC14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS01930
gene id: 595494:TOLA_RS01930
uniprot id: C4L997
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.
messages: Belongs to the GSP E family.
messages: Cell inner membrane

595494:TOLA RS02530
gene id: 595494:TOLA_RS02530
uniprot id: C4L9Y8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS01125
gene id: 595494:TOLA_RS01125
uniprot id: C4L8H0
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

595494:TOLA RS00685
gene id: 595494:TOLA_RS00685
uniprot id: C4L7W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

595494:TOLA RS08375
gene id: 595494:TOLA_RS08375
uniprot id: C4LF89
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS01590
gene id: 595494:TOLA_RS01590
uniprot id: C4L8R2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS04515
gene id: 595494:TOLA_RS04515
uniprot id: C4LC29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

595494:TOLA RS10740
gene id: 595494:TOLA_RS10740
uniprot id: C4L866
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

595494:TOLA RS10675
gene id: 595494:TOLA_RS10675
uniprot id: C4L852
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

595494:TOLA RS08700
gene id: 595494:TOLA_RS08700
uniprot id: C4LFF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS01475
gene id: 595494:TOLA_RS01475
uniprot id: C4L8P0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS01210
gene id: 595494:TOLA_RS01210
uniprot id: C4L8I7
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

595494:TOLA RS08015
gene id: 595494:TOLA_RS08015
uniprot id: C4LF17
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

595494:TOLA RS11625
gene id: 595494:TOLA_RS11625
uniprot id: C4L918
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS13330
gene id: 595494:TOLA_RS13330
uniprot id: C4LB13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

595494:TOLA RS03950
gene id: 595494:TOLA_RS03950
uniprot id: C4LBG3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS08860
gene id: 595494:TOLA_RS08860
uniprot id: C4LFI6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS04065
gene id: 595494:TOLA_RS04065
uniprot id: C4LBI7
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

595494:TOLA RS03215
gene id: 595494:TOLA_RS03215
uniprot id: C4LAP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

595494:TOLA RS15450
gene id: 595494:TOLA_RS15450
uniprot id: C4LD67
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

595494:TOLA RS01120
gene id: 595494:TOLA_RS01120
uniprot id: C4L8G9
names: Similarity
messages: Belongs to the VgrG protein family.

595494:TOLA RS10845
gene id: 595494:TOLA_RS10845
uniprot id: C4L887
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS02535
gene id: 595494:TOLA_RS02535
uniprot id: C4L9Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS13855
gene id: 595494:TOLA_RS13855
uniprot id: C4LBN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS03260
gene id: 595494:TOLA_RS03260
uniprot id: C4LAQ6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS01735
gene id: 595494:TOLA_RS01735
uniprot id: C4L959
names: Similarity
messages: Belongs to the YkuD family.

595494:TOLA RS08840
gene id: 595494:TOLA_RS08840
uniprot id: C4LFI2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

595494:TOLA RS08730
gene id: 595494:TOLA_RS08730
uniprot id: C4LFG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

595494:TOLA RS10990
gene id: 595494:TOLA_RS10990
uniprot id: C4L8B7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

595494:TOLA RS13865
gene id: 595494:TOLA_RS13865
uniprot id: C4LBN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS01520
gene id: 595494:TOLA_RS01520
uniprot id: C4L8P8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.

595494:TOLA RS04450
gene id: 595494:TOLA_RS04450
uniprot id: C4LC16
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

595494:TOLA RS14320
gene id: 595494:TOLA_RS14320
uniprot id: C4LBW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

595494:TOLA RS15940
gene id: 595494:TOLA_RS15940
uniprot id: C4LDT3
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS07780
gene id: 595494:TOLA_RS07780
uniprot id: C4LEX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

595494:TOLA RS01075
gene id: 595494:TOLA_RS01075
uniprot id: C4L830
names: Similarity
messages: Belongs to the ClpA/ClpB family.

595494:TOLA RS11160
gene id: 595494:TOLA_RS11160
uniprot id: C4L8F1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

595494:TOLA RS04955
gene id: 595494:TOLA_RS04955
uniprot id: C4LCM7
names: Similarity
messages: Belongs to the YggT family.

595494:TOLA RS00495
gene id: 595494:TOLA_RS00495
uniprot id: C4L7S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

595494:TOLA RS07625
gene id: 595494:TOLA_RS07625
uniprot id: C4LEU3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS11665
gene id: 595494:TOLA_RS11665
uniprot id: C4L926
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS07695
gene id: 595494:TOLA_RS07695
uniprot id: C4LEV6
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

595494:TOLA RS11800
gene id: 595494:TOLA_RS11800
uniprot id: C4L948
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

595494:TOLA RS00560
gene id: 595494:TOLA_RS00560
uniprot id: C4L7T8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

595494:TOLA RS15050
gene id: 595494:TOLA_RS15050
uniprot id: C4LCZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

595494:TOLA RS14685
gene id: 595494:TOLA_RS14685
uniprot id: C4LCF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the etk/wzc family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS01565
gene id: 595494:TOLA_RS01565
uniprot id: C4L8Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

595494:TOLA RS11905
gene id: 595494:TOLA_RS11905
uniprot id: C4L9I6
names: Similarity
messages: Belongs to the NifZ family.

595494:TOLA RS05630
gene id: 595494:TOLA_RS05630
uniprot id: C4LDD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS16130
gene id: 595494:TOLA_RS16130
uniprot id: C4LDX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

595494:TOLA RS06375
gene id: 595494:TOLA_RS06375
uniprot id: C4LE43
names: Similarity
messages: Belongs to the SAICAR synthetase family.

595494:TOLA RS13255
gene id: 595494:TOLA_RS13255
uniprot id: C4LAZ8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS06280
gene id: 595494:TOLA_RS06280
uniprot id: C4LE25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

595494:TOLA RS14580
gene id: 595494:TOLA_RS14580
uniprot id: C4LCD3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

595494:TOLA RS15600
gene id: 595494:TOLA_RS15600
uniprot id: C4LD96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS10435
gene id: 595494:TOLA_RS10435
uniprot id: C4L7N6
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS00585
gene id: 595494:TOLA_RS00585
uniprot id: C4L7U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

595494:TOLA RS09085
gene id: 595494:TOLA_RS09085
uniprot id: C4LFN1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS10810
gene id: 595494:TOLA_RS10810
uniprot id: C4L880
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

595494:TOLA RS07250
gene id: 595494:TOLA_RS07250
uniprot id: C4LEL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

595494:TOLA RS00600
gene id: 595494:TOLA_RS00600
uniprot id: C4L7U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

595494:TOLA RS08465
gene id: 595494:TOLA_RS08465
uniprot id: C4LFA7
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

595494:TOLA RS13840
gene id: 595494:TOLA_RS13840
uniprot id: C4LBN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

595494:TOLA RS12740
gene id: 595494:TOLA_RS12740
uniprot id: C4LAC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

595494:TOLA RS02175
gene id: 595494:TOLA_RS02175
uniprot id: C4L9E6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

595494:TOLA RS11245
gene id: 595494:TOLA_RS11245
uniprot id: C4L8U4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

595494:TOLA RS04115
gene id: 595494:TOLA_RS04115
uniprot id: C4LBJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

595494:TOLA RS10230
gene id: 595494:TOLA_RS10230
uniprot id: C4L7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

595494:TOLA RS02680
gene id: 595494:TOLA_RS02680
uniprot id: C4LA17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

595494:TOLA RS16080
gene id: 595494:TOLA_RS16080
uniprot id: C4LDW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

595494:TOLA RS11215
gene id: 595494:TOLA_RS11215
uniprot id: C4L8T8
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02195
gene id: 595494:TOLA_RS02195
uniprot id: C4L9F0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

595494:TOLA RS05550
gene id: 595494:TOLA_RS05550
uniprot id: C4LDB4
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

595494:TOLA RS06210
gene id: 595494:TOLA_RS06210
uniprot id: C4LE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

595494:TOLA RS13120
gene id: 595494:TOLA_RS13120
uniprot id: C4LAX1
names: Function
names: Similarity
messages: Belongs to the HIBADH-related family. 2-hydroxy-3-oxopropionate reductase subfamily.
messages: Catalyzes the reduction of tatronate semialdehyde to D-glycerate.

595494:TOLA RS06245
gene id: 595494:TOLA_RS06245
uniprot id: C4LE17
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

595494:TOLA RS15055
gene id: 595494:TOLA_RS15055
uniprot id: C4LCZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

595494:TOLA RS16125
gene id: 595494:TOLA_RS16125
uniprot id: C4LDX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

595494:TOLA RS16025
gene id: 595494:TOLA_RS16025
uniprot id: C4LDV0
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

595494:TOLA RS12580
gene id: 595494:TOLA_RS12580
uniprot id: C4LA92
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

595494:TOLA RS04865
gene id: 595494:TOLA_RS04865
uniprot id: C4LCL2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

595494:TOLA RS14640
gene id: 595494:TOLA_RS14640
uniprot id: C4LCE5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

595494:TOLA RS04080
gene id: 595494:TOLA_RS04080
uniprot id: C4LBJ0
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

595494:TOLA RS15220
gene id: 595494:TOLA_RS15220
uniprot id: C4LD26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

595494:TOLA RS12550
gene id: 595494:TOLA_RS12550
uniprot id: C4LA86
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10655
gene id: 595494:TOLA_RS10655
uniprot id: C4L848
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

595494:TOLA RS03480
gene id: 595494:TOLA_RS03480
uniprot id: C4LAV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

595494:TOLA RS15140
gene id: 595494:TOLA_RS15140
uniprot id: C4LD10
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

595494:TOLA RS12865
gene id: 595494:TOLA_RS12865
uniprot id: C4LAE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS11305
gene id: 595494:TOLA_RS11305
uniprot id: C4L8V5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

595494:TOLA RS02250
gene id: 595494:TOLA_RS02250
uniprot id: C4L9G1
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS01355
gene id: 595494:TOLA_RS01355
uniprot id: C4L8L6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

595494:TOLA RS15365
gene id: 595494:TOLA_RS15365
uniprot id: C4LD51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

595494:TOLA RS15840
gene id: 595494:TOLA_RS15840
uniprot id: C4LDR4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11850
gene id: 595494:TOLA_RS11850
uniprot id: C4L958
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS13165
gene id: 595494:TOLA_RS13165
uniprot id: C4LAY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS11030
gene id: 595494:TOLA_RS11030
uniprot id: C4L8C5
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

595494:TOLA RS14305
gene id: 595494:TOLA_RS14305
uniprot id: C4LBW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

595494:TOLA RS10205
gene id: 595494:TOLA_RS10205
uniprot id: C4L7J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

595494:TOLA RS10930
gene id: 595494:TOLA_RS10930
uniprot id: C4L8A4
names: Similarity
messages: Belongs to the aspartokinase family.

595494:TOLA RS08315
gene id: 595494:TOLA_RS08315
uniprot id: C4LF77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

595494:TOLA RS07055
gene id: 595494:TOLA_RS07055
uniprot id: C4LEI0
names: Similarity
messages: Belongs to the peptidase S49 family.

595494:TOLA RS00760
gene id: 595494:TOLA_RS00760
uniprot id: C4L7X8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

595494:TOLA RS10305
gene id: 595494:TOLA_RS10305
uniprot id: C4L7L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

595494:TOLA RS01845
gene id: 595494:TOLA_RS01845
uniprot id: C4L980
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

595494:TOLA RS07915
gene id: 595494:TOLA_RS07915
uniprot id: C4LEZ6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11820
gene id: 595494:TOLA_RS11820
uniprot id: C4L952
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

595494:TOLA RS08230
gene id: 595494:TOLA_RS08230
uniprot id: C4LF60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

595494:TOLA RS00675
gene id: 595494:TOLA_RS00675
uniprot id: C4L7W1
names: Similarity
messages: Belongs to the acylphosphatase family.

595494:TOLA RS10225
gene id: 595494:TOLA_RS10225
uniprot id: C4L7J4
names: Similarity
messages: Belongs to the MlaA family.

595494:TOLA RS06395
gene id: 595494:TOLA_RS06395
uniprot id: C4LE47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

595494:TOLA RS04775
gene id: 595494:TOLA_RS04775
uniprot id: C4LC79
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

595494:TOLA RS10495
gene id: 595494:TOLA_RS10495
uniprot id: C4L7P8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

595494:TOLA RS03095
gene id: 595494:TOLA_RS03095
uniprot id: C4LAM5
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS13325
gene id: 595494:TOLA_RS13325
uniprot id: C4LB12
names: Similarity
messages: Belongs to the intimin/invasin family.

595494:TOLA RS13680
gene id: 595494:TOLA_RS13680
uniprot id: C4LB78
names: Similarity
messages: Belongs to the peptidase S13 family.

595494:TOLA RS04945
gene id: 595494:TOLA_RS04945
uniprot id: C4LCM5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

595494:TOLA RS10420
gene id: 595494:TOLA_RS10420
uniprot id: C4L7N3
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

595494:TOLA RS06360
gene id: 595494:TOLA_RS06360
uniprot id: C4LE40
names: Subunit
messages: Monomer.

595494:TOLA RS16005
gene id: 595494:TOLA_RS16005
uniprot id: C4LDU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

595494:TOLA RS12695
gene id: 595494:TOLA_RS12695
uniprot id: C4LAB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
messages: Belongs to the FrdD family.
messages: Cell inner membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

595494:TOLA RS08795
gene id: 595494:TOLA_RS08795
uniprot id: C4LFH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS13090
gene id: 595494:TOLA_RS13090
uniprot id: C4LAJ3
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

595494:TOLA RS13070
gene id: 595494:TOLA_RS13070
uniprot id: C4LAI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

595494:TOLA RS06095
gene id: 595494:TOLA_RS06095
uniprot id: C4LDL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

595494:TOLA RS11805
gene id: 595494:TOLA_RS11805
uniprot id: C4L949
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS11055
gene id: 595494:TOLA_RS11055
uniprot id: C4L8D0
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

595494:TOLA RS12890
gene id: 595494:TOLA_RS12890
uniprot id: C4LAF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

595494:TOLA RS03625
gene id: 595494:TOLA_RS03625
uniprot id: C4LB99
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

595494:TOLA RS03250
gene id: 595494:TOLA_RS03250
uniprot id: C4LAQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

595494:TOLA RS03505
gene id: 595494:TOLA_RS03505
uniprot id: C4LAV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS11300
gene id: 595494:TOLA_RS11300
uniprot id: C4L8V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

595494:TOLA RS02370
gene id: 595494:TOLA_RS02370
uniprot id: C4L9V6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

595494:TOLA RS09755
gene id: 595494:TOLA_RS09755
uniprot id: C4LG01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

595494:TOLA RS08880
gene id: 595494:TOLA_RS08880
uniprot id: C4LFJ0
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS00720
gene id: 595494:TOLA_RS00720
uniprot id: C4L7X0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00905
gene id: 595494:TOLA_RS00905
uniprot id: C4L800
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

595494:TOLA RS04605
gene id: 595494:TOLA_RS04605
uniprot id: C4LC47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS11340
gene id: 595494:TOLA_RS11340
uniprot id: C4L8W2
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

595494:TOLA RS09040
gene id: 595494:TOLA_RS09040
uniprot id: C4LFM2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

595494:TOLA RS00335
gene id: 595494:TOLA_RS00335
uniprot id: C4L7B5
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

595494:TOLA RS06970
gene id: 595494:TOLA_RS06970
uniprot id: C4LEG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS04385
gene id: 595494:TOLA_RS04385
uniprot id: C4LC03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

595494:TOLA RS10340
gene id: 595494:TOLA_RS10340
uniprot id: C4L7L7
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS08255
gene id: 595494:TOLA_RS08255
uniprot id: C4LF65
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

595494:TOLA RS14030
gene id: 595494:TOLA_RS14030
uniprot id: C4LBR4
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

595494:TOLA RS06140
gene id: 595494:TOLA_RS06140
uniprot id: C4LDZ7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

595494:TOLA RS04615
gene id: 595494:TOLA_RS04615
uniprot id: C4LC49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

595494:TOLA RS09385
gene id: 595494:TOLA_RS09385
uniprot id: C4LFU0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS09000
gene id: 595494:TOLA_RS09000
uniprot id: C4LFL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS11380
gene id: 595494:TOLA_RS11380
uniprot id: C4L8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

595494:TOLA RS16160
gene id: 595494:TOLA_RS16160
uniprot id: C4LDX8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS02705
gene id: 595494:TOLA_RS02705
uniprot id: C4LA22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

595494:TOLA RS04825
gene id: 595494:TOLA_RS04825
uniprot id: C4LC89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

595494:TOLA RS10135
gene id: 595494:TOLA_RS10135
uniprot id: C4L7H6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02420
gene id: 595494:TOLA_RS02420
uniprot id: C4L9W6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02665
gene id: 595494:TOLA_RS02665
uniprot id: C4LA15
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

595494:TOLA RS00950
gene id: 595494:TOLA_RS00950
uniprot id: C4L809
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

595494:TOLA RS10715
gene id: 595494:TOLA_RS10715
uniprot id: C4L860
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

595494:TOLA RS12720
gene id: 595494:TOLA_RS12720
uniprot id: C4LAB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

595494:TOLA RS11435
gene id: 595494:TOLA_RS11435
uniprot id: C4L8X9
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

595494:TOLA RS14255
gene id: 595494:TOLA_RS14255
uniprot id: C4LBV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

595494:TOLA RS14785
gene id: 595494:TOLA_RS14785
uniprot id: C4LCH3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

595494:TOLA RS15505
gene id: 595494:TOLA_RS15505
uniprot id: C4LD78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

595494:TOLA RS13115
gene id: 595494:TOLA_RS13115
uniprot id: C4LAJ8
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

595494:TOLA RS01920
gene id: 595494:TOLA_RS01920
uniprot id: C4L995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS11500
gene id: 595494:TOLA_RS11500
uniprot id: C4L8Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

595494:TOLA RS13960
gene id: 595494:TOLA_RS13960
uniprot id: C4LBQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

595494:TOLA RS08250
gene id: 595494:TOLA_RS08250
uniprot id: C4LF64
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

595494:TOLA RS13235
gene id: 595494:TOLA_RS13235
uniprot id: C4LAZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

595494:TOLA RS04225
gene id: 595494:TOLA_RS04225
uniprot id: C4LBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

595494:TOLA RS14125
gene id: 595494:TOLA_RS14125
uniprot id: C4LBT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS06820
gene id: 595494:TOLA_RS06820
uniprot id: C4LED5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS07050
gene id: 595494:TOLA_RS07050
uniprot id: C4LEH9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS10645
gene id: 595494:TOLA_RS10645
uniprot id: C4L846
names: Similarity
messages: Belongs to the MEMO1 family.

595494:TOLA RS04815
gene id: 595494:TOLA_RS04815
uniprot id: C4LC87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

595494:TOLA RS14590
gene id: 595494:TOLA_RS14590
uniprot id: C4LCD5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

595494:TOLA RS01035
gene id: 595494:TOLA_RS01035
uniprot id: C4L822
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

595494:TOLA RS12985
gene id: 595494:TOLA_RS12985
uniprot id: C4LAH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

595494:TOLA RS14220
gene id: 595494:TOLA_RS14220
uniprot id: C4LBU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

595494:TOLA RS04755
gene id: 595494:TOLA_RS04755
uniprot id: C4LC75
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

595494:TOLA RS07105
gene id: 595494:TOLA_RS07105
uniprot id: C4LEI8
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

595494:TOLA RS01885
gene id: 595494:TOLA_RS01885
uniprot id: C4L988
names: Similarity
messages: Belongs to the GSP N family.

595494:TOLA RS07125
gene id: 595494:TOLA_RS07125
uniprot id: C4LEJ2
names: Similarity
messages: Belongs to the fructosamine kinase family.

595494:TOLA RS04845
gene id: 595494:TOLA_RS04845
uniprot id: C4LC93
names: Cofactor
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.

595494:TOLA RS04760
gene id: 595494:TOLA_RS04760
uniprot id: C4LC76
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

595494:TOLA RS02085
gene id: 595494:TOLA_RS02085
uniprot id: C4L9C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

595494:TOLA RS01040
gene id: 595494:TOLA_RS01040
uniprot id: C4L823
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

595494:TOLA RS11390
gene id: 595494:TOLA_RS11390
uniprot id: C4L8X2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

595494:TOLA RS02155
gene id: 595494:TOLA_RS02155
uniprot id: C4L9E2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS00285
gene id: 595494:TOLA_RS00285
uniprot id: C4L7A5
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

595494:TOLA RS01965
gene id: 595494:TOLA_RS01965
uniprot id: C4L9A4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS07435
gene id: 595494:TOLA_RS07435
uniprot id: C4LEQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

595494:TOLA RS05265
gene id: 595494:TOLA_RS05265
uniprot id: C4LCT6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

595494:TOLA RS01470
gene id: 595494:TOLA_RS01470
uniprot id: C4L8N9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

595494:TOLA RS06705
gene id: 595494:TOLA_RS06705
uniprot id: C4LEA9
names: Similarity
messages: Belongs to the CvfB family.

595494:TOLA RS12020
gene id: 595494:TOLA_RS12020
uniprot id: C4L9K8
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

595494:TOLA RS14805
gene id: 595494:TOLA_RS14805
uniprot id: C4LCH5
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

595494:TOLA RS08320
gene id: 595494:TOLA_RS08320
uniprot id: C4LF78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

595494:TOLA RS02320
gene id: 595494:TOLA_RS02320
uniprot id: C4L9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

595494:TOLA RS01540
gene id: 595494:TOLA_RS01540
uniprot id: C4L8Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

595494:TOLA RS10490
gene id: 595494:TOLA_RS10490
uniprot id: C4L7P7
names: Similarity
messages: Belongs to the GppA/Ppx family.

595494:TOLA RS11015
gene id: 595494:TOLA_RS11015
uniprot id: C4L8C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00185
gene id: 595494:TOLA_RS00185
uniprot id: C4L785
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10095
gene id: 595494:TOLA_RS10095
uniprot id: C4L7G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

595494:TOLA RS07320
gene id: 595494:TOLA_RS07320
uniprot id: C4LEN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

595494:TOLA RS02000
gene id: 595494:TOLA_RS02000
uniprot id: C4L9B1
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

595494:TOLA RS13300
gene id: 595494:TOLA_RS13300
uniprot id: C4LB07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

595494:TOLA RS03200
gene id: 595494:TOLA_RS03200
uniprot id: C4LAP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

595494:TOLA RS13530
gene id: 595494:TOLA_RS13530
uniprot id: C4LB50
names: Similarity
messages: Belongs to the thioredoxin family.

595494:TOLA RS12875
gene id: 595494:TOLA_RS12875
uniprot id: C4LAE8
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

595494:TOLA RS08495
gene id: 595494:TOLA_RS08495
uniprot id: C4LFB3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

595494:TOLA RS00985
gene id: 595494:TOLA_RS00985
uniprot id: C4L816
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

595494:TOLA RS01385
gene id: 595494:TOLA_RS01385
uniprot id: C4L8M2
names: Similarity
messages: Belongs to the peptidase U62 family.

595494:TOLA RS04555
gene id: 595494:TOLA_RS04555
uniprot id: C4LC37
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

595494:TOLA RS09345
gene id: 595494:TOLA_RS09345
uniprot id: C4LFT2
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS13420
gene id: 595494:TOLA_RS13420
uniprot id: C4LB28
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS04860
gene id: 595494:TOLA_RS04860
uniprot id: C4LCL1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

595494:TOLA RS05270
gene id: 595494:TOLA_RS05270
uniprot id: C4LCT7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

595494:TOLA RS11540
gene id: 595494:TOLA_RS11540
uniprot id: C4L900
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

595494:TOLA RS14775
gene id: 595494:TOLA_RS14775
uniprot id: C4LCH1
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

595494:TOLA RS04185
gene id: 595494:TOLA_RS04185
uniprot id: C4LBL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS01320
gene id: 595494:TOLA_RS01320
uniprot id: C4L8K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

595494:TOLA RS14400
gene id: 595494:TOLA_RS14400
uniprot id: C4LC98
names: Similarity
messages: Belongs to the UPF0178 family.

595494:TOLA RS07560
gene id: 595494:TOLA_RS07560
uniprot id: C4LET0
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS05520
gene id: 595494:TOLA_RS05520
uniprot id: C4LDA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

595494:TOLA RS06100
gene id: 595494:TOLA_RS06100
uniprot id: C4LDL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

595494:TOLA RS11040
gene id: 595494:TOLA_RS11040
uniprot id: C4L8C7
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

595494:TOLA RS10265
gene id: 595494:TOLA_RS10265
uniprot id: C4L7K2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

595494:TOLA RS00910
gene id: 595494:TOLA_RS00910
uniprot id: C4L801
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS01325
gene id: 595494:TOLA_RS01325
uniprot id: C4L8L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS03960
gene id: 595494:TOLA_RS03960
uniprot id: C4LBG5
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS05540
gene id: 595494:TOLA_RS05540
uniprot id: C4LDB2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

595494:TOLA RS14425
gene id: 595494:TOLA_RS14425
uniprot id: C4LCA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

595494:TOLA RS15925
gene id: 595494:TOLA_RS15925
uniprot id: C4LDT0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

595494:TOLA RS13060
gene id: 595494:TOLA_RS13060
uniprot id: C4LAI7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS05285
gene id: 595494:TOLA_RS05285
uniprot id: C4LCU0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS13440
gene id: 595494:TOLA_RS13440
uniprot id: C4LB32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

595494:TOLA RS01630
gene id: 595494:TOLA_RS01630
uniprot id: C4L8S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

595494:TOLA RS10430
gene id: 595494:TOLA_RS10430
uniprot id: C4L7N5
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

595494:TOLA RS06005
gene id: 595494:TOLA_RS06005
uniprot id: C4LDK0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
messages: Homooctamer; tetramer of dimers.
messages: Reaction proceeds via a syn dehydration.

595494:TOLA RS13850
gene id: 595494:TOLA_RS13850
uniprot id: C4LBN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

595494:TOLA RS02855
gene id: 595494:TOLA_RS02855
uniprot id: C4LA53
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

595494:TOLA RS06425
gene id: 595494:TOLA_RS06425
uniprot id: C4LE53
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS15210
gene id: 595494:TOLA_RS15210
uniprot id: C4LD24
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

595494:TOLA RS13975
gene id: 595494:TOLA_RS13975
uniprot id: C4LBQ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

595494:TOLA RS00420
gene id: 595494:TOLA_RS00420
uniprot id: C4L7D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

595494:TOLA RS01645
gene id: 595494:TOLA_RS01645
uniprot id: C4L8S5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

595494:TOLA RS12935
gene id: 595494:TOLA_RS12935
uniprot id: C4LAG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

595494:TOLA RS01255
gene id: 595494:TOLA_RS01255
uniprot id: C4L8J6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS07970
gene id: 595494:TOLA_RS07970
uniprot id: C4LF08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

595494:TOLA RS07785
gene id: 595494:TOLA_RS07785
uniprot id: C4LEX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

595494:TOLA RS02150
gene id: 595494:TOLA_RS02150
uniprot id: C4L9E1
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11070
gene id: 595494:TOLA_RS11070
uniprot id: C4L8D3
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue.

595494:TOLA RS15945
gene id: 595494:TOLA_RS15945
uniprot id: C4LDT4
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

595494:TOLA RS04135
gene id: 595494:TOLA_RS04135
uniprot id: C4LBK0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

595494:TOLA RS15035
gene id: 595494:TOLA_RS15035
uniprot id: C4LCY9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

595494:TOLA RS12980
gene id: 595494:TOLA_RS12980
uniprot id: C4LAH0
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS16240
gene id: 595494:TOLA_RS16240
uniprot id: C4LDZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

595494:TOLA RS01195
gene id: 595494:TOLA_RS01195
uniprot id: C4L8I4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

595494:TOLA RS00990
gene id: 595494:TOLA_RS00990
uniprot id: C4L817
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

595494:TOLA RS15455
gene id: 595494:TOLA_RS15455
uniprot id: C4LD68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

595494:TOLA RS04355
gene id: 595494:TOLA_RS04355
uniprot id: C4LBZ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS07230
gene id: 595494:TOLA_RS07230
uniprot id: C4LEL3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

595494:TOLA RS01865
gene id: 595494:TOLA_RS01865
uniprot id: C4L984
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS11855
gene id: 595494:TOLA_RS11855
uniprot id: C4L9H6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS01130
gene id: 595494:TOLA_RS01130
uniprot id: C4L8H1
names: Similarity
messages: Belongs to the GST superfamily.

595494:TOLA RS13720
gene id: 595494:TOLA_RS13720
uniprot id: C4LB86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

595494:TOLA RS15390
gene id: 595494:TOLA_RS15390
uniprot id: C4LD56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

595494:TOLA RS11680
gene id: 595494:TOLA_RS11680
uniprot id: C4L929
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

595494:TOLA RS02925
gene id: 595494:TOLA_RS02925
uniprot id: C4LA66
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

595494:TOLA RS11065
gene id: 595494:TOLA_RS11065
uniprot id: C4L8D2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

595494:TOLA RS05225
gene id: 595494:TOLA_RS05225
uniprot id: C4LCS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

595494:TOLA RS05830
gene id: 595494:TOLA_RS05830
uniprot id: C4LDG7
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

595494:TOLA RS10310
gene id: 595494:TOLA_RS10310
uniprot id: C4L7L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

595494:TOLA RS00660
gene id: 595494:TOLA_RS00660
uniprot id: C4L7V8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS10120
gene id: 595494:TOLA_RS10120
uniprot id: C4L7H3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS01925
gene id: 595494:TOLA_RS01925
uniprot id: C4L996
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

595494:TOLA RS05660
gene id: 595494:TOLA_RS05660
uniprot id: C4LDD6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

595494:TOLA RS14035
gene id: 595494:TOLA_RS14035
uniprot id: C4LBR5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

595494:TOLA RS16140
gene id: 595494:TOLA_RS16140
uniprot id: C4LDX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

595494:TOLA RS04835
gene id: 595494:TOLA_RS04835
uniprot id: C4LC91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

595494:TOLA RS02700
gene id: 595494:TOLA_RS02700
uniprot id: C4LA21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

595494:TOLA RS11235
gene id: 595494:TOLA_RS11235
uniprot id: C4L8U2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS16060
gene id: 595494:TOLA_RS16060
uniprot id: C4LDV7
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

595494:TOLA RS16220
gene id: 595494:TOLA_RS16220
uniprot id: C4LDZ0
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

595494:TOLA RS13565
gene id: 595494:TOLA_RS13565
uniprot id: C4LB57
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

595494:TOLA RS02675
gene id: 595494:TOLA_RS02675
uniprot id: C4LA16
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

595494:TOLA RS11455
gene id: 595494:TOLA_RS11455
uniprot id: C4L8Y3
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

595494:TOLA RS13365
gene id: 595494:TOLA_RS13365
uniprot id: C4LB20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

595494:TOLA RS13405
gene id: 595494:TOLA_RS13405
uniprot id: C4LB25
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

595494:TOLA RS14290
gene id: 595494:TOLA_RS14290
uniprot id: C4LBV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

595494:TOLA RS00320
gene id: 595494:TOLA_RS00320
uniprot id: C4L7B2
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

595494:TOLA RS15150
gene id: 595494:TOLA_RS15150
uniprot id: C4LD12
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

595494:TOLA RS13205
gene id: 595494:TOLA_RS13205
uniprot id: C4LAY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

595494:TOLA RS12725
gene id: 595494:TOLA_RS12725
uniprot id: C4LAB8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

595494:TOLA RS00275
gene id: 595494:TOLA_RS00275
uniprot id: C4L7A3
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

595494:TOLA RS10325
gene id: 595494:TOLA_RS10325
uniprot id: C4L7L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

595494:TOLA RS14185
gene id: 595494:TOLA_RS14185
uniprot id: C4LBT9
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

595494:TOLA RS11405
gene id: 595494:TOLA_RS11405
uniprot id: C4L8X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

595494:TOLA RS11260
gene id: 595494:TOLA_RS11260
uniprot id: C4L8U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS11105
gene id: 595494:TOLA_RS11105
uniprot id: C4L8E0
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

595494:TOLA RS14965
gene id: 595494:TOLA_RS14965
uniprot id: C4LCK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

595494:TOLA RS15110
gene id: 595494:TOLA_RS15110
uniprot id: C4LD04
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS08680
gene id: 595494:TOLA_RS08680
uniprot id: C4LFF0
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

595494:TOLA RS07840
gene id: 595494:TOLA_RS07840
uniprot id: C4LEY4
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

595494:TOLA RS07690
gene id: 595494:TOLA_RS07690
uniprot id: C4LEV5
names: Subunit
messages: Monomer.

595494:TOLA RS10750
gene id: 595494:TOLA_RS10750
uniprot id: C4L868
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

595494:TOLA RS07390
gene id: 595494:TOLA_RS07390
uniprot id: C4LEP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS07350
gene id: 595494:TOLA_RS07350
uniprot id: C4LEN8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

595494:TOLA RS07155
gene id: 595494:TOLA_RS07155
uniprot id: C4LEJ8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS16185
gene id: 595494:TOLA_RS16185
uniprot id: C4LDY3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

595494:TOLA RS15960
gene id: 595494:TOLA_RS15960
uniprot id: C4LDT7
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

595494:TOLA RS07075
gene id: 595494:TOLA_RS07075
uniprot id: C4LEI2
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

595494:TOLA RS03240
gene id: 595494:TOLA_RS03240
uniprot id: C4LAQ2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

595494:TOLA RS12760
gene id: 595494:TOLA_RS12760
uniprot id: C4LAC5
names: Similarity
messages: Belongs to the ArsC family.

595494:TOLA RS06390
gene id: 595494:TOLA_RS06390
uniprot id: C4LE46
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

595494:TOLA RS10900
gene id: 595494:TOLA_RS10900
uniprot id: C4L898
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

595494:TOLA RS06510
gene id: 595494:TOLA_RS06510
uniprot id: C4LE70
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

595494:TOLA RS07555
gene id: 595494:TOLA_RS07555
uniprot id: C4LES9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

595494:TOLA RS07865
gene id: 595494:TOLA_RS07865
uniprot id: C4LEY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

595494:TOLA RS05675
gene id: 595494:TOLA_RS05675
uniprot id: C4LDD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS15460
gene id: 595494:TOLA_RS15460
uniprot id: C4LD69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

595494:TOLA RS04570
gene id: 595494:TOLA_RS04570
uniprot id: C4LC40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

595494:TOLA RS13095
gene id: 595494:TOLA_RS13095
uniprot id: C4LAJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 3 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

595494:TOLA RS08550
gene id: 595494:TOLA_RS08550
uniprot id: C4LFC4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

595494:TOLA RS03540
gene id: 595494:TOLA_RS03540
uniprot id: C4LAW3
names: Similarity
messages: Belongs to the YjdM family.

595494:TOLA RS05125
gene id: 595494:TOLA_RS05125
uniprot id: C4LCQ8
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS07835
gene id: 595494:TOLA_RS07835
uniprot id: C4LEY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

595494:TOLA RS12060
gene id: 595494:TOLA_RS12060
uniprot id: C4L9L6
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

595494:TOLA RS01980
gene id: 595494:TOLA_RS01980
uniprot id: C4L9A7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

595494:TOLA RS11090
gene id: 595494:TOLA_RS11090
uniprot id: C4L8D7
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

595494:TOLA RS06535
gene id: 595494:TOLA_RS06535
uniprot id: C4LE75
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS00330
gene id: 595494:TOLA_RS00330
uniprot id: C4L7B4
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

595494:TOLA RS12595
gene id: 595494:TOLA_RS12595
uniprot id: C4LA95
names: Similarity
messages: Belongs to the universal stress protein A family.

595494:TOLA RS14440
gene id: 595494:TOLA_RS14440
uniprot id: C4LCA6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

595494:TOLA RS02620
gene id: 595494:TOLA_RS02620
uniprot id: C4LA06
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

595494:TOLA RS04235
gene id: 595494:TOLA_RS04235
uniprot id: C4LBX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS00015
gene id: 595494:TOLA_RS00015
uniprot id: C4L757
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

595494:TOLA RS13795
gene id: 595494:TOLA_RS13795
uniprot id: C4LBM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

595494:TOLA RS07215
gene id: 595494:TOLA_RS07215
uniprot id: C4LEL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AlgX family.
messages: Periplasm

595494:TOLA RS04030
gene id: 595494:TOLA_RS04030
uniprot id: C4LBI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

595494:TOLA RS08045
gene id: 595494:TOLA_RS08045
uniprot id: C4LF23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

595494:TOLA RS08020
gene id: 595494:TOLA_RS08020
uniprot id: C4LF18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

595494:TOLA RS02750
gene id: 595494:TOLA_RS02750
uniprot id: C4LA32
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: May bind 1 zinc ion per subunit.
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

595494:TOLA RS07540
gene id: 595494:TOLA_RS07540
uniprot id: C4LES6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS03990
gene id: 595494:TOLA_RS03990
uniprot id: C4LBH1
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

595494:TOLA RS07030
gene id: 595494:TOLA_RS07030
uniprot id: C4LEH5
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS01005
gene id: 595494:TOLA_RS01005
uniprot id: C4L820
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS08830
gene id: 595494:TOLA_RS08830
uniprot id: C4LFI0
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

595494:TOLA RS10795
gene id: 595494:TOLA_RS10795
uniprot id: C4L877
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

595494:TOLA RS01860
gene id: 595494:TOLA_RS01860
uniprot id: C4L983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

595494:TOLA RS03390
gene id: 595494:TOLA_RS03390
uniprot id: C4LAT3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

595494:TOLA RS11425
gene id: 595494:TOLA_RS11425
uniprot id: C4L8X7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS13785
gene id: 595494:TOLA_RS13785
uniprot id: C4LBM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

595494:TOLA RS15195
gene id: 595494:TOLA_RS15195
uniprot id: C4LD21
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

595494:TOLA RS00715
gene id: 595494:TOLA_RS00715
uniprot id: C4L7W9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS15380
gene id: 595494:TOLA_RS15380
uniprot id: C4LD54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

595494:TOLA RS02540
gene id: 595494:TOLA_RS02540
uniprot id: C4L9Z0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

595494:TOLA RS11835
gene id: 595494:TOLA_RS11835
uniprot id: C4L955
names: Function
names: Subunit
messages: Interacts with sigma-54.
messages: Required for activation of most nif operons, which are directly involved in nitrogen fixation.

595494:TOLA RS10385
gene id: 595494:TOLA_RS10385
uniprot id: C4L7M6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS08835
gene id: 595494:TOLA_RS08835
uniprot id: C4LFI1
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

595494:TOLA RS16390
gene id: 595494:TOLA_RS16390
uniprot id: C4LAY3
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS08895
gene id: 595494:TOLA_RS08895
uniprot id: C4LFJ3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

595494:TOLA RS01170
gene id: 595494:TOLA_RS01170
uniprot id: C4L8H9
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

595494:TOLA RS15880
gene id: 595494:TOLA_RS15880
uniprot id: C4LDS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

595494:TOLA RS01635
gene id: 595494:TOLA_RS01635
uniprot id: C4L8S2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS02995
gene id: 595494:TOLA_RS02995
uniprot id: C4LAK5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

595494:TOLA RS04725
gene id: 595494:TOLA_RS04725
uniprot id: C4LC69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

595494:TOLA RS11325
gene id: 595494:TOLA_RS11325
uniprot id: C4L8V9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS05805
gene id: 595494:TOLA_RS05805
uniprot id: C4LDG1
names: Similarity
messages: Belongs to the ArsC family.

595494:TOLA RS00250
gene id: 595494:TOLA_RS00250
uniprot id: C4L798
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

595494:TOLA RS12845
gene id: 595494:TOLA_RS12845
uniprot id: C4LAE2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

595494:TOLA RS10285
gene id: 595494:TOLA_RS10285
uniprot id: C4L7K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

595494:TOLA RS15905
gene id: 595494:TOLA_RS15905
uniprot id: C4LDS6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS03245
gene id: 595494:TOLA_RS03245
uniprot id: C4LAQ3
names: Similarity
messages: Belongs to the YkuD family.

595494:TOLA RS00630
gene id: 595494:TOLA_RS00630
uniprot id: C4L7V2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

595494:TOLA RS07430
gene id: 595494:TOLA_RS07430
uniprot id: C4LEQ5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

595494:TOLA RS04195
gene id: 595494:TOLA_RS04195
uniprot id: C4LBL2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

595494:TOLA RS14990
gene id: 595494:TOLA_RS14990
uniprot id: C4LCK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

595494:TOLA RS04055
gene id: 595494:TOLA_RS04055
uniprot id: C4LBI5
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

595494:TOLA RS14120
gene id: 595494:TOLA_RS14120
uniprot id: C4LBT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS02950
gene id: 595494:TOLA_RS02950
uniprot id: C4LA71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

595494:TOLA RS09600
gene id: 595494:TOLA_RS09600
uniprot id: C4LFX5
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

595494:TOLA RS00085
gene id: 595494:TOLA_RS00085
uniprot id: C4L771
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS05030
gene id: 595494:TOLA_RS05030
uniprot id: C4LCP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

595494:TOLA RS07795
gene id: 595494:TOLA_RS07795
uniprot id: C4LEX5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

595494:TOLA RS09660
gene id: 595494:TOLA_RS09660
uniprot id: C4LFY7
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

595494:TOLA RS05555
gene id: 595494:TOLA_RS05555
uniprot id: C4LDB5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

595494:TOLA RS08930
gene id: 595494:TOLA_RS08930
uniprot id: C4LFK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

595494:TOLA RS14675
gene id: 595494:TOLA_RS14675
uniprot id: C4LCF2
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS08475
gene id: 595494:TOLA_RS08475
uniprot id: C4LFA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

595494:TOLA RS13130
gene id: 595494:TOLA_RS13130
uniprot id: C4LAX3
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

595494:TOLA RS00255
gene id: 595494:TOLA_RS00255
uniprot id: C4L799
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by ATP and maltotriose, which are both required for DNA binding.
messages: Belongs to the MalT family.
messages: Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
messages: Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.

595494:TOLA RS13250
gene id: 595494:TOLA_RS13250
uniprot id: C4LAZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

595494:TOLA RS01420
gene id: 595494:TOLA_RS01420
uniprot id: C4L8M9
names: Similarity
messages: Belongs to the SufE family.

595494:TOLA RS08770
gene id: 595494:TOLA_RS08770
uniprot id: C4LFG8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

595494:TOLA RS05915
gene id: 595494:TOLA_RS05915
uniprot id: C4LDI2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

595494:TOLA RS04660
gene id: 595494:TOLA_RS04660
uniprot id: C4LC56
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

595494:TOLA RS07340
gene id: 595494:TOLA_RS07340
uniprot id: C4LEN6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS13450
gene id: 595494:TOLA_RS13450
uniprot id: C4LB34
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

595494:TOLA RS08450
gene id: 595494:TOLA_RS08450
uniprot id: C4LFA4
names: Similarity
messages: Belongs to the UPF0251 family.

595494:TOLA RS01515
gene id: 595494:TOLA_RS01515
uniprot id: C4L8P7
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

595494:TOLA RS11205
gene id: 595494:TOLA_RS11205
uniprot id: C4L8G0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

595494:TOLA RS06935
gene id: 595494:TOLA_RS06935
uniprot id: C4LEF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

595494:TOLA RS15445
gene id: 595494:TOLA_RS15445
uniprot id: C4LD66
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

595494:TOLA RS10190
gene id: 595494:TOLA_RS10190
uniprot id: C4L7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.

595494:TOLA RS04460
gene id: 595494:TOLA_RS04460
uniprot id: C4LC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS05100
gene id: 595494:TOLA_RS05100
uniprot id: C4LCQ3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

595494:TOLA RS05580
gene id: 595494:TOLA_RS05580
uniprot id: C4LDC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

595494:TOLA RS08600
gene id: 595494:TOLA_RS08600
uniprot id: C4LFD4
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

595494:TOLA RS01825
gene id: 595494:TOLA_RS01825
uniprot id: C4L976
names: Similarity
messages: Belongs to the FrmR/RcnR family.

595494:TOLA RS10090
gene id: 595494:TOLA_RS10090
uniprot id: C4L7G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00740
gene id: 595494:TOLA_RS00740
uniprot id: C4L7X4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS07820
gene id: 595494:TOLA_RS07820
uniprot id: C4LEY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

595494:TOLA RS06905
gene id: 595494:TOLA_RS06905
uniprot id: C4LEF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

595494:TOLA RS11155
gene id: 595494:TOLA_RS11155
uniprot id: C4L8F0
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

595494:TOLA RS12095
gene id: 595494:TOLA_RS12095
uniprot id: C4L9M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

595494:TOLA RS03945
gene id: 595494:TOLA_RS03945
uniprot id: C4LBG2
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11400
gene id: 595494:TOLA_RS11400
uniprot id: C4L8X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

595494:TOLA RS01230
gene id: 595494:TOLA_RS01230
uniprot id: C4L8J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

595494:TOLA RS13275
gene id: 595494:TOLA_RS13275
uniprot id: C4LB02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS10065
gene id: 595494:TOLA_RS10065
uniprot id: C4L7G2
names: Similarity
messages: Belongs to the LacAB/RpiB family.

595494:TOLA RS16155
gene id: 595494:TOLA_RS16155
uniprot id: C4LDX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

595494:TOLA RS00780
gene id: 595494:TOLA_RS00780
uniprot id: C4L7Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

595494:TOLA RS04960
gene id: 595494:TOLA_RS04960
uniprot id: C4LCM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

595494:TOLA RS04620
gene id: 595494:TOLA_RS04620
uniprot id: C4LC50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

595494:TOLA RS16095
gene id: 595494:TOLA_RS16095
uniprot id: C4LDW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

595494:TOLA RS10635
gene id: 595494:TOLA_RS10635
uniprot id: C4L844
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS02920
gene id: 595494:TOLA_RS02920
uniprot id: C4LA65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

595494:TOLA RS13885
gene id: 595494:TOLA_RS13885
uniprot id: C4LBP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00490
gene id: 595494:TOLA_RS00490
uniprot id: C4L7S4
names: Similarity
messages: Belongs to the peptidase M20A family. ArgE subfamily.

595494:TOLA RS10735
gene id: 595494:TOLA_RS10735
uniprot id: C4L864
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

595494:TOLA RS12975
gene id: 595494:TOLA_RS12975
uniprot id: C4LAG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

595494:TOLA RS06760
gene id: 595494:TOLA_RS06760
uniprot id: C4LEC4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS04540
gene id: 595494:TOLA_RS04540
uniprot id: C4LC34
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

595494:TOLA RS10685
gene id: 595494:TOLA_RS10685
uniprot id: C4L854
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

595494:TOLA RS15915
gene id: 595494:TOLA_RS15915
uniprot id: C4LDS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

595494:TOLA RS15515
gene id: 595494:TOLA_RS15515
uniprot id: C4LD80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

595494:TOLA RS15650
gene id: 595494:TOLA_RS15650
uniprot id: C4LDM6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

595494:TOLA RS16670
gene id: 595494:TOLA_RS16670
uniprot id: C4LFC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS16245
gene id: 595494:TOLA_RS16245
uniprot id: C4LEB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

595494:TOLA RS10520
gene id: 595494:TOLA_RS10520
uniprot id: C4L7Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

595494:TOLA RS11460
gene id: 595494:TOLA_RS11460
uniprot id: C4L8Y4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

595494:TOLA RS10590
gene id: 595494:TOLA_RS10590
uniprot id: C4L837
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

595494:TOLA RS06055
gene id: 595494:TOLA_RS06055
uniprot id: C4LDL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

595494:TOLA RS09605
gene id: 595494:TOLA_RS09605
uniprot id: C4LFX6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS16045
gene id: 595494:TOLA_RS16045
uniprot id: C4LDV4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

595494:TOLA RS10665
gene id: 595494:TOLA_RS10665
uniprot id: C4L850
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

595494:TOLA RS14260
gene id: 595494:TOLA_RS14260
uniprot id: C4LBV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

595494:TOLA RS15765
gene id: 595494:TOLA_RS15765
uniprot id: C4LDP9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

595494:TOLA RS14680
gene id: 595494:TOLA_RS14680
uniprot id: C4LCF3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. WecA subfamily.
messages: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS09265
gene id: 595494:TOLA_RS09265
uniprot id: C4LFR6
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

595494:TOLA RS02505
gene id: 595494:TOLA_RS02505
uniprot id: C4L9Y3
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

595494:TOLA RS11430
gene id: 595494:TOLA_RS11430
uniprot id: C4L8X8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

595494:TOLA RS11190
gene id: 595494:TOLA_RS11190
uniprot id: C4L8F7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

595494:TOLA RS00075
gene id: 595494:TOLA_RS00075
uniprot id: C4L769
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

595494:TOLA RS01265
gene id: 595494:TOLA_RS01265
uniprot id: C4L8J8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS11470
gene id: 595494:TOLA_RS11470
uniprot id: C4L8Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

595494:TOLA RS06415
gene id: 595494:TOLA_RS06415
uniprot id: C4LE51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

595494:TOLA RS03220
gene id: 595494:TOLA_RS03220
uniprot id: C4LAP8
names: Similarity
messages: Belongs to the threonine synthase family.

595494:TOLA RS15355
gene id: 595494:TOLA_RS15355
uniprot id: C4LD49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

595494:TOLA RS07355
gene id: 595494:TOLA_RS07355
uniprot id: C4LEN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

595494:TOLA RS08500
gene id: 595494:TOLA_RS08500
uniprot id: C4LFB4
names: Function
names: Similarity
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin.

595494:TOLA RS02940
gene id: 595494:TOLA_RS02940
uniprot id: C4LA69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

595494:TOLA RS02510
gene id: 595494:TOLA_RS02510
uniprot id: C4L9Y4
names: Similarity
messages: Belongs to the FBPase class 2 family.

595494:TOLA RS03405
gene id: 595494:TOLA_RS03405
uniprot id: C4LAT6
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.

595494:TOLA RS07610
gene id: 595494:TOLA_RS07610
uniprot id: C4LEU0
names: Similarity
messages: Belongs to the universal stress protein A family.

595494:TOLA RS16020
gene id: 595494:TOLA_RS16020
uniprot id: C4LDU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

595494:TOLA RS03375
gene id: 595494:TOLA_RS03375
uniprot id: C4LAT0
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

595494:TOLA RS06885
gene id: 595494:TOLA_RS06885
uniprot id: C4LEE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

595494:TOLA RS07045
gene id: 595494:TOLA_RS07045
uniprot id: C4LEH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Membrane

595494:TOLA RS01135
gene id: 595494:TOLA_RS01135
uniprot id: C4L8H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:citrate (SCF) symporter family.
messages: Cell membrane

595494:TOLA RS11685
gene id: 595494:TOLA_RS11685
uniprot id: C4L930
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

595494:TOLA RS00435
gene id: 595494:TOLA_RS00435
uniprot id: C4L7R3
names: Similarity
messages: Belongs to the peptidase S9A family.

595494:TOLA RS11775
gene id: 595494:TOLA_RS11775
uniprot id: C4L943
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

595494:TOLA RS00640
gene id: 595494:TOLA_RS00640
uniprot id: C4L7V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

595494:TOLA RS04175
gene id: 595494:TOLA_RS04175
uniprot id: C4LBK8
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02010
gene id: 595494:TOLA_RS02010
uniprot id: C4L9B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).
messages: Cell inner membrane

595494:TOLA RS02020
gene id: 595494:TOLA_RS02020
uniprot id: C4L9B5
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10370
gene id: 595494:TOLA_RS10370
uniprot id: C4L7M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

595494:TOLA RS10480
gene id: 595494:TOLA_RS10480
uniprot id: C4L7P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS05800
gene id: 595494:TOLA_RS05800
uniprot id: C4LDG0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

595494:TOLA RS09675
gene id: 595494:TOLA_RS09675
uniprot id: C4LFZ0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00575
gene id: 595494:TOLA_RS00575
uniprot id: C4L7U1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

595494:TOLA RS00670
gene id: 595494:TOLA_RS00670
uniprot id: C4L7W0
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

595494:TOLA RS13955
gene id: 595494:TOLA_RS13955
uniprot id: C4LBP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

595494:TOLA RS01895
gene id: 595494:TOLA_RS01895
uniprot id: C4L990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP L family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

595494:TOLA RS04025
gene id: 595494:TOLA_RS04025
uniprot id: C4LBH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.

595494:TOLA RS03345
gene id: 595494:TOLA_RS03345
uniprot id: C4LAS3
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

595494:TOLA RS13825
gene id: 595494:TOLA_RS13825
uniprot id: C4LBM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

595494:TOLA RS07665
gene id: 595494:TOLA_RS07665
uniprot id: C4LEV1
names: Subunit
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.

595494:TOLA RS11645
gene id: 595494:TOLA_RS11645
uniprot id: C4L922
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

595494:TOLA RS13910
gene id: 595494:TOLA_RS13910
uniprot id: C4LBP5
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

595494:TOLA RS07965
gene id: 595494:TOLA_RS07965
uniprot id: C4LF07
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

595494:TOLA RS08560
gene id: 595494:TOLA_RS08560
uniprot id: C4LFC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

595494:TOLA RS14835
gene id: 595494:TOLA_RS14835
uniprot id: C4LCI1
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

595494:TOLA RS14210
gene id: 595494:TOLA_RS14210
uniprot id: C4LBU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

595494:TOLA RS13835
gene id: 595494:TOLA_RS13835
uniprot id: C4LBN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

595494:TOLA RS10005
gene id: 595494:TOLA_RS10005
uniprot id: C4L7F0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

595494:TOLA RS06365
gene id: 595494:TOLA_RS06365
uniprot id: C4LE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

595494:TOLA RS10970
gene id: 595494:TOLA_RS10970
uniprot id: C4L8B3
names: Similarity
messages: Belongs to the ribulokinase family.

595494:TOLA RS14420
gene id: 595494:TOLA_RS14420
uniprot id: C4LCA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

595494:TOLA RS05680
gene id: 595494:TOLA_RS05680
uniprot id: C4LDE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS03980
gene id: 595494:TOLA_RS03980
uniprot id: C4LBG9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

595494:TOLA RS08605
gene id: 595494:TOLA_RS08605
uniprot id: C4LFD5
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

595494:TOLA RS02685
gene id: 595494:TOLA_RS02685
uniprot id: C4LA18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

595494:TOLA RS09255
gene id: 595494:TOLA_RS09255
uniprot id: C4LFR4
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

595494:TOLA RS06200
gene id: 595494:TOLA_RS06200
uniprot id: C4LE09
names: Similarity
messages: Belongs to the NadC/ModD family.

595494:TOLA RS06155
gene id: 595494:TOLA_RS06155
uniprot id: C4LE00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

595494:TOLA RS04405
gene id: 595494:TOLA_RS04405
uniprot id: C4LC07
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

595494:TOLA RS16395
gene id: 595494:TOLA_RS16395
uniprot id: C4LCC1
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

595494:TOLA RS04520
gene id: 595494:TOLA_RS04520
uniprot id: C4LC30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS07600
gene id: 595494:TOLA_RS07600
uniprot id: C4LET8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS00010
gene id: 595494:TOLA_RS00010
uniprot id: C4L756
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

595494:TOLA RS11935
gene id: 595494:TOLA_RS11935
uniprot id: C4L9J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
messages: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
messages: Cytoplasm
messages: Homotetramer.

595494:TOLA RS16070
gene id: 595494:TOLA_RS16070
uniprot id: C4LDV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

595494:TOLA RS11830
gene id: 595494:TOLA_RS11830
uniprot id: C4L954
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

595494:TOLA RS15375
gene id: 595494:TOLA_RS15375
uniprot id: C4LD53
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

595494:TOLA RS02830
gene id: 595494:TOLA_RS02830
uniprot id: C4LA48
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS06505
gene id: 595494:TOLA_RS06505
uniprot id: C4LE69
names: Similarity
messages: Belongs to the Nudix hydrolase family.

595494:TOLA RS03385
gene id: 595494:TOLA_RS03385
uniprot id: C4LAT2
names: Similarity
messages: Belongs to the NifX/NifY family.

595494:TOLA RS01755
gene id: 595494:TOLA_RS01755
uniprot id: C4L963
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

595494:TOLA RS01375
gene id: 595494:TOLA_RS01375
uniprot id: C4L8M0
names: Similarity
messages: Belongs to the peptidase U62 family.

595494:TOLA RS10890
gene id: 595494:TOLA_RS10890
uniprot id: C4L896
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

595494:TOLA RS00680
gene id: 595494:TOLA_RS00680
uniprot id: C4L7W2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

595494:TOLA RS15465
gene id: 595494:TOLA_RS15465
uniprot id: C4LD70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

595494:TOLA RS04420
gene id: 595494:TOLA_RS04420
uniprot id: C4LC10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SeqA family.
messages: Cytoplasm
messages: Homodimer. Polymerizes to form helical filaments.
messages: Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

595494:TOLA RS11210
gene id: 595494:TOLA_RS11210
uniprot id: C4L8G1
names: Similarity
messages: Belongs to the asparagine synthetase family.

595494:TOLA RS00510
gene id: 595494:TOLA_RS00510
uniprot id: C4L7S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

595494:TOLA RS07480
gene id: 595494:TOLA_RS07480
uniprot id: C4LER4
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

595494:TOLA RS12870
gene id: 595494:TOLA_RS12870
uniprot id: C4LAE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

595494:TOLA RS07495
gene id: 595494:TOLA_RS07495
uniprot id: C4LER7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00525
gene id: 595494:TOLA_RS00525
uniprot id: C4L7T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

595494:TOLA RS11690
gene id: 595494:TOLA_RS11690
uniprot id: C4L931
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

595494:TOLA RS00045
gene id: 595494:TOLA_RS00045
uniprot id: C4L763
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

595494:TOLA RS11075
gene id: 595494:TOLA_RS11075
uniprot id: C4L8D4
names: Similarity
messages: Belongs to the UPF0115 family.

595494:TOLA RS07235
gene id: 595494:TOLA_RS07235
uniprot id: C4LEL4
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

595494:TOLA RS12895
gene id: 595494:TOLA_RS12895
uniprot id: C4LAF2
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

595494:TOLA RS12605
gene id: 595494:TOLA_RS12605
uniprot id: C4LA98
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

595494:TOLA RS03490
gene id: 595494:TOLA_RS03490
uniprot id: C4LAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

595494:TOLA RS03040
gene id: 595494:TOLA_RS03040
uniprot id: C4LAL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

595494:TOLA RS12120
gene id: 595494:TOLA_RS12120
uniprot id: C4L9M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

595494:TOLA RS15485
gene id: 595494:TOLA_RS15485
uniprot id: C4LD74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNR ribonuclease family. RNase II subfamily.
messages: Cytoplasm
messages: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.

595494:TOLA RS12790
gene id: 595494:TOLA_RS12790
uniprot id: C4LAD1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

595494:TOLA RS02690
gene id: 595494:TOLA_RS02690
uniprot id: C4LA19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

595494:TOLA RS14450
gene id: 595494:TOLA_RS14450
uniprot id: C4LCA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

595494:TOLA RS14315
gene id: 595494:TOLA_RS14315
uniprot id: C4LBW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

595494:TOLA RS01820
gene id: 595494:TOLA_RS01820
uniprot id: C4L975
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell inner membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).

595494:TOLA RS05215
gene id: 595494:TOLA_RS05215
uniprot id: C4LCS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS00625
gene id: 595494:TOLA_RS00625
uniprot id: C4L7V1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

595494:TOLA RS11150
gene id: 595494:TOLA_RS11150
uniprot id: C4L8E9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

595494:TOLA RS13005
gene id: 595494:TOLA_RS13005
uniprot id: C4LAH5
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS13555
gene id: 595494:TOLA_RS13555
uniprot id: C4LB55
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

595494:TOLA RS00005
gene id: 595494:TOLA_RS00005
uniprot id: C4L755
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

595494:TOLA RS04795
gene id: 595494:TOLA_RS04795
uniprot id: C4LC83
names: Similarity
messages: Belongs to the UDPGP type 2 family.

595494:TOLA RS07420
gene id: 595494:TOLA_RS07420
uniprot id: C4LEQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS13805
gene id: 595494:TOLA_RS13805
uniprot id: C4LBM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

595494:TOLA RS05280
gene id: 595494:TOLA_RS05280
uniprot id: C4LCT9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

595494:TOLA RS04950
gene id: 595494:TOLA_RS04950
uniprot id: C4LCM6
names: Similarity
messages: Belongs to the UPF0235 family.

595494:TOLA RS03350
gene id: 595494:TOLA_RS03350
uniprot id: C4LAS5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-101 inactivates the nitrogenase reductase and regulates nitrogenase activity.

595494:TOLA RS09820
gene id: 595494:TOLA_RS09820
uniprot id: C4LG12
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

595494:TOLA RS14535
gene id: 595494:TOLA_RS14535
uniprot id: C4LCC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

595494:TOLA RS15115
gene id: 595494:TOLA_RS15115
uniprot id: C4LD05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PilY1 family.
messages: Fimbrium

595494:TOLA RS14280
gene id: 595494:TOLA_RS14280
uniprot id: C4LBV8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS09890
gene id: 595494:TOLA_RS09890
uniprot id: C4LG26
names: Similarity
messages: Belongs to the xylose isomerase family.

595494:TOLA RS10910
gene id: 595494:TOLA_RS10910
uniprot id: C4L8A0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

595494:TOLA RS07490
gene id: 595494:TOLA_RS07490
uniprot id: C4LER6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS07960
gene id: 595494:TOLA_RS07960
uniprot id: C4LF06
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

595494:TOLA RS06920
gene id: 595494:TOLA_RS06920
uniprot id: C4LEF3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS15335
gene id: 595494:TOLA_RS15335
uniprot id: C4LD45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

595494:TOLA RS08520
gene id: 595494:TOLA_RS08520
uniprot id: C4LFB8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

595494:TOLA RS04710
gene id: 595494:TOLA_RS04710
uniprot id: C4LC66
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

595494:TOLA RS15510
gene id: 595494:TOLA_RS15510
uniprot id: C4LD79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

595494:TOLA RS10220
gene id: 595494:TOLA_RS10220
uniprot id: C4L7J3
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

595494:TOLA RS02635
gene id: 595494:TOLA_RS02635
uniprot id: C4LA09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

595494:TOLA RS06480
gene id: 595494:TOLA_RS06480
uniprot id: C4LE64
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

595494:TOLA RS02790
gene id: 595494:TOLA_RS02790
uniprot id: C4LA40
names: Similarity
messages: Belongs to the GARS family.

595494:TOLA RS14500
gene id: 595494:TOLA_RS14500
uniprot id: C4LCB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

595494:TOLA RS08565
gene id: 595494:TOLA_RS08565
uniprot id: C4LFC7
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

595494:TOLA RS06975
gene id: 595494:TOLA_RS06975
uniprot id: C4LEG4
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

595494:TOLA RS02105
gene id: 595494:TOLA_RS02105
uniprot id: C4L9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

595494:TOLA RS15920
gene id: 595494:TOLA_RS15920
uniprot id: C4LDS9
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

595494:TOLA RS02130
gene id: 595494:TOLA_RS02130
uniprot id: C4L9D7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

595494:TOLA RS13525
gene id: 595494:TOLA_RS13525
uniprot id: C4LB49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

595494:TOLA RS07645
gene id: 595494:TOLA_RS07645
uniprot id: C4LEU7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS12955
gene id: 595494:TOLA_RS12955
uniprot id: C4LAG5
names: Function
names: Similarity
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

595494:TOLA RS14925
gene id: 595494:TOLA_RS14925
uniprot id: C4LCJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS05640
gene id: 595494:TOLA_RS05640
uniprot id: C4LDD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

595494:TOLA RS11395
gene id: 595494:TOLA_RS11395
uniprot id: C4L8X3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

595494:TOLA RS02525
gene id: 595494:TOLA_RS02525
uniprot id: C4L9Y7
names: Similarity
messages: Belongs to the glutamate synthase family.

595494:TOLA RS01745
gene id: 595494:TOLA_RS01745
uniprot id: C4L961
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

595494:TOLA RS15875
gene id: 595494:TOLA_RS15875
uniprot id: C4LDS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

595494:TOLA RS01370
gene id: 595494:TOLA_RS01370
uniprot id: C4L8L9
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

595494:TOLA RS04700
gene id: 595494:TOLA_RS04700
uniprot id: C4LC64
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

595494:TOLA RS13390
gene id: 595494:TOLA_RS13390
uniprot id: C4LB22
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

595494:TOLA RS00730
gene id: 595494:TOLA_RS00730
uniprot id: C4L7X2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

595494:TOLA RS03180
gene id: 595494:TOLA_RS03180
uniprot id: C4LAP0
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

595494:TOLA RS11655
gene id: 595494:TOLA_RS11655
uniprot id: C4L924
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

595494:TOLA RS14200
gene id: 595494:TOLA_RS14200
uniprot id: C4LBU2
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

595494:TOLA RS04105
gene id: 595494:TOLA_RS04105
uniprot id: C4LBJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

595494:TOLA RS01415
gene id: 595494:TOLA_RS01415
uniprot id: C4L8M8
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

595494:TOLA RS01900
gene id: 595494:TOLA_RS01900
uniprot id: C4L991
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14650
gene id: 595494:TOLA_RS14650
uniprot id: C4LCE7
names: Similarity
messages: Belongs to the CapA family.

595494:TOLA RS12960
gene id: 595494:TOLA_RS12960
uniprot id: C4LAG6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

595494:TOLA RS13245
gene id: 595494:TOLA_RS13245
uniprot id: C4LAZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

595494:TOLA RS05245
gene id: 595494:TOLA_RS05245
uniprot id: C4LCT2
names: Similarity
messages: Belongs to the pyruvate kinase family.

595494:TOLA RS13215
gene id: 595494:TOLA_RS13215
uniprot id: C4LAZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

595494:TOLA RS04590
gene id: 595494:TOLA_RS04590
uniprot id: C4LC44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

595494:TOLA RS11545
gene id: 595494:TOLA_RS11545
uniprot id: C4L901
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

595494:TOLA RS00880
gene id: 595494:TOLA_RS00880
uniprot id: C4L7Z5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

595494:TOLA RS02055
gene id: 595494:TOLA_RS02055
uniprot id: C4L9C2
names: Function
names: Similarity
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.

595494:TOLA RS05730
gene id: 595494:TOLA_RS05730
uniprot id: C4LDE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

595494:TOLA RS14190
gene id: 595494:TOLA_RS14190
uniprot id: C4LBU0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

595494:TOLA RS01945
gene id: 595494:TOLA_RS01945
uniprot id: C4L9A0
names: Similarity
messages: Belongs to the GSP C family.

595494:TOLA RS15215
gene id: 595494:TOLA_RS15215
uniprot id: C4LD25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

595494:TOLA RS10745
gene id: 595494:TOLA_RS10745
uniprot id: C4L867
names: Activity Regulation
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

595494:TOLA RS15585
gene id: 595494:TOLA_RS15585
uniprot id: C4LD93
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

595494:TOLA RS04100
gene id: 595494:TOLA_RS04100
uniprot id: C4LBJ4
names: Similarity
messages: Belongs to the BolA/IbaG family.

595494:TOLA RS02495
gene id: 595494:TOLA_RS02495
uniprot id: C4L9Y1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

595494:TOLA RS07945
gene id: 595494:TOLA_RS07945
uniprot id: C4LF02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

595494:TOLA RS05120
gene id: 595494:TOLA_RS05120
uniprot id: C4LCQ7
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

595494:TOLA RS11695
gene id: 595494:TOLA_RS11695
uniprot id: C4L932
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

595494:TOLA RS07360
gene id: 595494:TOLA_RS07360
uniprot id: C4LEP0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

595494:TOLA RS09120
gene id: 595494:TOLA_RS09120
uniprot id: C4LFN8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

595494:TOLA RS07270
gene id: 595494:TOLA_RS07270
uniprot id: C4LEM1
names: Similarity
messages: Belongs to the peptidase S16 family.

595494:TOLA RS01530
gene id: 595494:TOLA_RS01530
uniprot id: C4L8Q0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

595494:TOLA RS15065
gene id: 595494:TOLA_RS15065
uniprot id: C4LCZ5
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

595494:TOLA RS04500
gene id: 595494:TOLA_RS04500
uniprot id: C4LC26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

595494:TOLA RS04665
gene id: 595494:TOLA_RS04665
uniprot id: C4LC57
names: Similarity
messages: Belongs to the transglycosylase Slt family.

595494:TOLA RS04505
gene id: 595494:TOLA_RS04505
uniprot id: C4LC27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

595494:TOLA RS06310
gene id: 595494:TOLA_RS06310
uniprot id: C4LE31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS13455
gene id: 595494:TOLA_RS13455
uniprot id: C4LB35
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

595494:TOLA RS00530
gene id: 595494:TOLA_RS00530
uniprot id: C4L7T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

595494:TOLA RS12125
gene id: 595494:TOLA_RS12125
uniprot id: C4L9M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

595494:TOLA RS14135
gene id: 595494:TOLA_RS14135
uniprot id: C4LBT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

595494:TOLA RS13580
gene id: 595494:TOLA_RS13580
uniprot id: C4LB60
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

595494:TOLA RS11915
gene id: 595494:TOLA_RS11915
uniprot id: C4L9I8
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

595494:TOLA RS05590
gene id: 595494:TOLA_RS05590
uniprot id: C4LDC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS01770
gene id: 595494:TOLA_RS01770
uniprot id: C4L967
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

595494:TOLA RS14330
gene id: 595494:TOLA_RS14330
uniprot id: C4LBW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

595494:TOLA RS04250
gene id: 595494:TOLA_RS04250
uniprot id: C4LBX9
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

595494:TOLA RS04830
gene id: 595494:TOLA_RS04830
uniprot id: C4LC90
names: Function
names: Similarity
messages: Belongs to the TrpC family.
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

595494:TOLA RS15740
gene id: 595494:TOLA_RS15740
uniprot id: C4LDP4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS14060
gene id: 595494:TOLA_RS14060
uniprot id: C4LBS0
names: Similarity
messages: Belongs to the UPF0270 family.

595494:TOLA RS09770
gene id: 595494:TOLA_RS09770
uniprot id: C4LG04
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS11170
gene id: 595494:TOLA_RS11170
uniprot id: C4L8F3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

595494:TOLA RS04745
gene id: 595494:TOLA_RS04745
uniprot id: C4LC73
names: Similarity
messages: Belongs to the UPF0352 family.

595494:TOLA RS03380
gene id: 595494:TOLA_RS03380
uniprot id: C4LAT1
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

595494:TOLA RS02005
gene id: 595494:TOLA_RS02005
uniprot id: C4L9B2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

595494:TOLA RS13430
gene id: 595494:TOLA_RS13430
uniprot id: C4LB30
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

595494:TOLA RS13845
gene id: 595494:TOLA_RS13845
uniprot id: C4LBN2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

595494:TOLA RS08845
gene id: 595494:TOLA_RS08845
uniprot id: C4LFI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

595494:TOLA RS09275
gene id: 595494:TOLA_RS09275
uniprot id: C4LFR8
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

595494:TOLA RS05735
gene id: 595494:TOLA_RS05735
uniprot id: C4LDE6
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homomer.

595494:TOLA RS02945
gene id: 595494:TOLA_RS02945
uniprot id: C4LA70
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

595494:TOLA RS12100
gene id: 595494:TOLA_RS12100
uniprot id: C4L9M4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

595494:TOLA RS00700
gene id: 595494:TOLA_RS00700
uniprot id: C4L7W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. KdkA/RfaP family.
messages: Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14930
gene id: 595494:TOLA_RS14930
uniprot id: C4LCJ5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Binds 1 sodium ion per monomer.
messages: Binds 2 magnesium ions per monomer.
messages: Homotetramer.

595494:TOLA RS06750
gene id: 595494:TOLA_RS06750
uniprot id: C4LEC2
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

595494:TOLA RS00565
gene id: 595494:TOLA_RS00565
uniprot id: C4L7T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

595494:TOLA RS06530
gene id: 595494:TOLA_RS06530
uniprot id: C4LE74
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS08430
gene id: 595494:TOLA_RS08430
uniprot id: C4LFA0
names: Similarity
messages: Belongs to the NadC/ModD family.

595494:TOLA RS04510
gene id: 595494:TOLA_RS04510
uniprot id: C4LC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0208 family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS05325
gene id: 595494:TOLA_RS05325
uniprot id: C4LCU8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

595494:TOLA RS02160
gene id: 595494:TOLA_RS02160
uniprot id: C4L9E3
names: Similarity
messages: Belongs to the class-I fumarase family.

595494:TOLA RS01580
gene id: 595494:TOLA_RS01580
uniprot id: C4L8R0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

595494:TOLA RS00355
gene id: 595494:TOLA_RS00355
uniprot id: C4L7B9
names: Similarity
messages: Belongs to the DEAD box helicase family.

595494:TOLA RS00615
gene id: 595494:TOLA_RS00615
uniprot id: C4L7U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

595494:TOLA RS13100
gene id: 595494:TOLA_RS13100
uniprot id: C4LAJ5
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

595494:TOLA RS13045
gene id: 595494:TOLA_RS13045
uniprot id: C4LAI4
names: Similarity
messages: Belongs to the UPF0166 family.

595494:TOLA RS11910
gene id: 595494:TOLA_RS11910
uniprot id: C4L9I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifW family.
messages: Homotrimer; associates with NifD.
messages: May protect the nitrogenase Fe-Mo protein from oxidative damage.

595494:TOLA RS09635
gene id: 595494:TOLA_RS09635
uniprot id: C4LFY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

595494:TOLA RS15525
gene id: 595494:TOLA_RS15525
uniprot id: C4LD82
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS00815
gene id: 595494:TOLA_RS00815
uniprot id: C4L7Y9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

595494:TOLA RS12065
gene id: 595494:TOLA_RS12065
uniprot id: C4L9L7
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

595494:TOLA RS11465
gene id: 595494:TOLA_RS11465
uniprot id: C4L8Y5
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

595494:TOLA RS00755
gene id: 595494:TOLA_RS00755
uniprot id: C4L7X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

595494:TOLA RS12690
gene id: 595494:TOLA_RS12690
uniprot id: C4LAB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
messages: Belongs to the FrdC family.
messages: Cell inner membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

595494:TOLA RS15275
gene id: 595494:TOLA_RS15275
uniprot id: C4LD33
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

595494:TOLA RS08480
gene id: 595494:TOLA_RS08480
uniprot id: C4LFB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

595494:TOLA RS10235
gene id: 595494:TOLA_RS10235
uniprot id: C4L7J6
names: Similarity
messages: Belongs to the peptidase M17 family.

595494:TOLA RS12925
gene id: 595494:TOLA_RS12925
uniprot id: C4LAF8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS16200
gene id: 595494:TOLA_RS16200
uniprot id: C4LDY6
names: Similarity
messages: Belongs to the KdgT transporter family.

595494:TOLA RS04090
gene id: 595494:TOLA_RS04090
uniprot id: C4LBJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmG family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.

595494:TOLA RS12560
gene id: 595494:TOLA_RS12560
uniprot id: C4LA88
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

595494:TOLA RS11480
gene id: 595494:TOLA_RS11480
uniprot id: C4L8Y8
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

595494:TOLA RS01400
gene id: 595494:TOLA_RS01400
uniprot id: C4L8M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

595494:TOLA RS02470
gene id: 595494:TOLA_RS02470
uniprot id: C4L9X6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS07635
gene id: 595494:TOLA_RS07635
uniprot id: C4LEU5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS03985
gene id: 595494:TOLA_RS03985
uniprot id: C4LBH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

595494:TOLA RS03620
gene id: 595494:TOLA_RS03620
uniprot id: C4LB98
names: Similarity
messages: Belongs to the transposase 8 family.

595494:TOLA RS16075
gene id: 595494:TOLA_RS16075
uniprot id: C4LDW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

595494:TOLA RS12620
gene id: 595494:TOLA_RS12620
uniprot id: C4LAA1
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

595494:TOLA RS10195
gene id: 595494:TOLA_RS10195
uniprot id: C4L7I8
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

595494:TOLA RS04350
gene id: 595494:TOLA_RS04350
uniprot id: C4LBZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

595494:TOLA RS02725
gene id: 595494:TOLA_RS02725
uniprot id: C4LA26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

595494:TOLA RS03955
gene id: 595494:TOLA_RS03955
uniprot id: C4LBG4
names: Function
names: Similarity
messages: Belongs to the CowN family.
messages: Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO.

595494:TOLA RS06195
gene id: 595494:TOLA_RS06195
uniprot id: C4LE08
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

595494:TOLA RS14240
gene id: 595494:TOLA_RS14240
uniprot id: C4LBV0
names: Similarity
messages: Belongs to the RutC family.

595494:TOLA RS13355
gene id: 595494:TOLA_RS13355
uniprot id: C4LB18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane
messages: Membrane

595494:TOLA RS14265
gene id: 595494:TOLA_RS14265
uniprot id: C4LBV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

595494:TOLA RS13990
gene id: 595494:TOLA_RS13990
uniprot id: C4LBQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

595494:TOLA RS02435
gene id: 595494:TOLA_RS02435
uniprot id: C4L9W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

595494:TOLA RS04375
gene id: 595494:TOLA_RS04375
uniprot id: C4LC01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

595494:TOLA RS13970
gene id: 595494:TOLA_RS13970
uniprot id: C4LBQ2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

595494:TOLA RS12905
gene id: 595494:TOLA_RS12905
uniprot id: C4LAF4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02395
gene id: 595494:TOLA_RS02395
uniprot id: C4L9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell inner membrane

595494:TOLA RS03110
gene id: 595494:TOLA_RS03110
uniprot id: C4LAM8
names: Similarity
messages: Belongs to the pyruvate kinase family.

595494:TOLA RS00960
gene id: 595494:TOLA_RS00960
uniprot id: C4L811
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

595494:TOLA RS07925
gene id: 595494:TOLA_RS07925
uniprot id: C4LEZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

595494:TOLA RS03510
gene id: 595494:TOLA_RS03510
uniprot id: C4LAV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

595494:TOLA RS15415
gene id: 595494:TOLA_RS15415
uniprot id: C4LD61
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

595494:TOLA RS13185
gene id: 595494:TOLA_RS13185
uniprot id: C4LAY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS07505
gene id: 595494:TOLA_RS07505
uniprot id: C4LER9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

595494:TOLA RS12750
gene id: 595494:TOLA_RS12750
uniprot id: C4LAC3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

595494:TOLA RS15435
gene id: 595494:TOLA_RS15435
uniprot id: C4LD64
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

595494:TOLA RS04445
gene id: 595494:TOLA_RS04445
uniprot id: C4LC15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS14115
gene id: 595494:TOLA_RS14115
uniprot id: C4LBT1
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS16195
gene id: 595494:TOLA_RS16195
uniprot id: C4LDY5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

595494:TOLA RS08875
gene id: 595494:TOLA_RS08875
uniprot id: C4LFI9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS08890
gene id: 595494:TOLA_RS08890
uniprot id: C4LFJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

595494:TOLA RS07100
gene id: 595494:TOLA_RS07100
uniprot id: C4LEI7
names: Similarity
messages: Belongs to the DEAD box helicase family.

595494:TOLA RS07525
gene id: 595494:TOLA_RS07525
uniprot id: C4LES3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS08325
gene id: 595494:TOLA_RS08325
uniprot id: C4LF79
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

595494:TOLA RS01165
gene id: 595494:TOLA_RS01165
uniprot id: C4L8H8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS06160
gene id: 595494:TOLA_RS06160
uniprot id: C4LE01
names: Similarity
messages: Belongs to the UPF0251 family.

595494:TOLA RS06825
gene id: 595494:TOLA_RS06825
uniprot id: C4LED6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS01995
gene id: 595494:TOLA_RS01995
uniprot id: C4L9B0
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS14485
gene id: 595494:TOLA_RS14485
uniprot id: C4LCB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

595494:TOLA RS03230
gene id: 595494:TOLA_RS03230
uniprot id: C4LAQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

595494:TOLA RS03355
gene id: 595494:TOLA_RS03355
uniprot id: C4LAS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

595494:TOLA RS12780
gene id: 595494:TOLA_RS12780
uniprot id: C4LAC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS07985
gene id: 595494:TOLA_RS07985
uniprot id: C4LF11
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

595494:TOLA RS11845
gene id: 595494:TOLA_RS11845
uniprot id: C4L957
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS02095
gene id: 595494:TOLA_RS02095
uniprot id: C4L9D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

595494:TOLA RS05180
gene id: 595494:TOLA_RS05180
uniprot id: C4LCR9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

595494:TOLA RS02190
gene id: 595494:TOLA_RS02190
uniprot id: C4L9E9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

595494:TOLA RS00955
gene id: 595494:TOLA_RS00955
uniprot id: C4L810
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

595494:TOLA RS01690
gene id: 595494:TOLA_RS01690
uniprot id: C4L8T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

595494:TOLA RS10775
gene id: 595494:TOLA_RS10775
uniprot id: C4L873
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS00550
gene id: 595494:TOLA_RS00550
uniprot id: C4L7T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

595494:TOLA RS11960
gene id: 595494:TOLA_RS11960
uniprot id: C4L9J8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

595494:TOLA RS06765
gene id: 595494:TOLA_RS06765
uniprot id: C4LEC5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS15005
gene id: 595494:TOLA_RS15005
uniprot id: C4LCY3
names: Similarity
messages: Belongs to the peptidase S1C family.

595494:TOLA RS16385
gene id: 595494:TOLA_RS16385
uniprot id: C4LAD6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS11135
gene id: 595494:TOLA_RS11135
uniprot id: C4L8E6
names: Similarity
messages: Belongs to the fabD family.

595494:TOLA RS03900
gene id: 595494:TOLA_RS03900
uniprot id: C4LBF3
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

595494:TOLA RS15695
gene id: 595494:TOLA_RS15695
uniprot id: C4LDN5
names: Similarity
messages: Belongs to the alkaline phosphatase family.

595494:TOLA RS01775
gene id: 595494:TOLA_RS01775
uniprot id: C4L968
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

595494:TOLA RS13305
gene id: 595494:TOLA_RS13305
uniprot id: C4LB08
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS15285
gene id: 595494:TOLA_RS15285
uniprot id: C4LD35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

595494:TOLA RS09565
gene id: 595494:TOLA_RS09565
uniprot id: C4LFW8
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

595494:TOLA RS05635
gene id: 595494:TOLA_RS05635
uniprot id: C4LDD1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane

595494:TOLA RS14310
gene id: 595494:TOLA_RS14310
uniprot id: C4LBW1
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

595494:TOLA RS13950
gene id: 595494:TOLA_RS13950
uniprot id: C4LBP8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

595494:TOLA RS13900
gene id: 595494:TOLA_RS13900
uniprot id: C4LBP3
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

595494:TOLA RS09055
gene id: 595494:TOLA_RS09055
uniprot id: C4LFM5
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS04200
gene id: 595494:TOLA_RS04200
uniprot id: C4LBL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

595494:TOLA RS04985
gene id: 595494:TOLA_RS04985
uniprot id: C4LCN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. SrmB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
messages: Interacts with the 50S ribosomal subunit.

595494:TOLA RS07520
gene id: 595494:TOLA_RS07520
uniprot id: C4LES2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

595494:TOLA RS08850
gene id: 595494:TOLA_RS08850
uniprot id: C4LFI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

595494:TOLA RS07445
gene id: 595494:TOLA_RS07445
uniprot id: C4LEQ8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
messages: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS01915
gene id: 595494:TOLA_RS01915
uniprot id: C4L994
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS12035
gene id: 595494:TOLA_RS12035
uniprot id: C4L9L1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

595494:TOLA RS00735
gene id: 595494:TOLA_RS00735
uniprot id: C4L7X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GlpE family.
messages: Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
messages: Cytoplasm

595494:TOLA RS10025
gene id: 595494:TOLA_RS10025
uniprot id: C4L7F4
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family. AlsE subfamily.
messages: Catalyzes the reversible epimerization of D-allulose 6-phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

595494:TOLA RS05085
gene id: 595494:TOLA_RS05085
uniprot id: C4LCQ0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS08055
gene id: 595494:TOLA_RS08055
uniprot id: C4LF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

595494:TOLA RS15085
gene id: 595494:TOLA_RS15085
uniprot id: C4LCZ9
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

595494:TOLA RS14180
gene id: 595494:TOLA_RS14180
uniprot id: C4LBT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

595494:TOLA RS11860
gene id: 595494:TOLA_RS11860
uniprot id: C4L9H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS13490
gene id: 595494:TOLA_RS13490
uniprot id: C4LB42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

595494:TOLA RS11175
gene id: 595494:TOLA_RS11175
uniprot id: C4L8F4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

595494:TOLA RS08460
gene id: 595494:TOLA_RS08460
uniprot id: C4LFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

595494:TOLA RS09090
gene id: 595494:TOLA_RS09090
uniprot id: C4LFN2
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

595494:TOLA RS12840
gene id: 595494:TOLA_RS12840
uniprot id: C4LAE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

595494:TOLA RS15540
gene id: 595494:TOLA_RS15540
uniprot id: C4LD85
names: Similarity
messages: Belongs to the UxaA family.

595494:TOLA RS02385
gene id: 595494:TOLA_RS02385
uniprot id: C4L9V9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

595494:TOLA RS13870
gene id: 595494:TOLA_RS13870
uniprot id: C4LBN7
names: Similarity
messages: Belongs to the PhoH family.

595494:TOLA RS10875
gene id: 595494:TOLA_RS10875
uniprot id: C4L893
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS00535
gene id: 595494:TOLA_RS00535
uniprot id: C4L7T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

595494:TOLA RS12090
gene id: 595494:TOLA_RS12090
uniprot id: C4L9M2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

595494:TOLA RS08305
gene id: 595494:TOLA_RS08305
uniprot id: C4LF75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS03010
gene id: 595494:TOLA_RS03010
uniprot id: C4LAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS16085
gene id: 595494:TOLA_RS16085
uniprot id: C4LDW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

595494:TOLA RS06420
gene id: 595494:TOLA_RS06420
uniprot id: C4LE52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

595494:TOLA RS11920
gene id: 595494:TOLA_RS11920
uniprot id: C4L9I9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS00515
gene id: 595494:TOLA_RS00515
uniprot id: C4L7S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

595494:TOLA RS10335
gene id: 595494:TOLA_RS10335
uniprot id: C4L7L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

595494:TOLA RS00875
gene id: 595494:TOLA_RS00875
uniprot id: C4L7Z4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

595494:TOLA RS16355
gene id: 595494:TOLA_RS16355
uniprot id: C4LFP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

595494:TOLA RS00800
gene id: 595494:TOLA_RS00800
uniprot id: C4L7Y6
names: Similarity
messages: Belongs to the DprA/Smf family.

595494:TOLA RS02440
gene id: 595494:TOLA_RS02440
uniprot id: C4L9X0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

595494:TOLA RS02655
gene id: 595494:TOLA_RS02655
uniprot id: C4LA13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

595494:TOLA RS14435
gene id: 595494:TOLA_RS14435
uniprot id: C4LCA5
names: Similarity
messages: Belongs to the CutA family.

595494:TOLA RS02405
gene id: 595494:TOLA_RS02405
uniprot id: C4L9W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

595494:TOLA RS13310
gene id: 595494:TOLA_RS13310
uniprot id: C4LB09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

595494:TOLA RS02030
gene id: 595494:TOLA_RS02030
uniprot id: C4L9B7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

595494:TOLA RS09110
gene id: 595494:TOLA_RS09110
uniprot id: C4LFN6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

595494:TOLA RS14000
gene id: 595494:TOLA_RS14000
uniprot id: C4LBQ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

595494:TOLA RS12345
gene id: 595494:TOLA_RS12345
uniprot id: C4L9R8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

595494:TOLA RS02480
gene id: 595494:TOLA_RS02480
uniprot id: C4L9X8
names: Similarity
messages: Belongs to the agmatine deiminase family.

595494:TOLA RS03560
gene id: 595494:TOLA_RS03560
uniprot id: C4LAW7
names: Similarity
messages: Belongs to the Gfa family.

595494:TOLA RS14375
gene id: 595494:TOLA_RS14375
uniprot id: C4LBX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

595494:TOLA RS04565
gene id: 595494:TOLA_RS04565
uniprot id: C4LC39
names: Similarity
messages: Belongs to the YfgM family.

595494:TOLA RS04930
gene id: 595494:TOLA_RS04930
uniprot id: C4LCM2
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

595494:TOLA RS00245
gene id: 595494:TOLA_RS00245
uniprot id: C4L797
names: Similarity
messages: Belongs to the disproportionating enzyme family.

595494:TOLA RS11815
gene id: 595494:TOLA_RS11815
uniprot id: C4L951
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

595494:TOLA RS00500
gene id: 595494:TOLA_RS00500
uniprot id: C4L7S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

595494:TOLA RS08955
gene id: 595494:TOLA_RS08955
uniprot id: C4LFK5
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

595494:TOLA RS02065
gene id: 595494:TOLA_RS02065
uniprot id: C4L9C4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.

595494:TOLA RS02740
gene id: 595494:TOLA_RS02740
uniprot id: C4LA29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

595494:TOLA RS14630
gene id: 595494:TOLA_RS14630
uniprot id: C4LCE3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

595494:TOLA RS12015
gene id: 595494:TOLA_RS12015
uniprot id: C4L9K7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

595494:TOLA RS02225
gene id: 595494:TOLA_RS02225
uniprot id: C4L9F6
names: Similarity
messages: Belongs to the UPF0102 family.

595494:TOLA RS07290
gene id: 595494:TOLA_RS07290
uniprot id: C4LEM6
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

595494:TOLA RS05445
gene id: 595494:TOLA_RS05445
uniprot id: C4LCX4
names: Similarity
messages: Belongs to the transposase 8 family.

595494:TOLA RS08470
gene id: 595494:TOLA_RS08470
uniprot id: C4LFA8
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

595494:TOLA RS10955
gene id: 595494:TOLA_RS10955
uniprot id: C4L8A9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS05205
gene id: 595494:TOLA_RS05205
uniprot id: C4LCS4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

595494:TOLA RS07025
gene id: 595494:TOLA_RS07025
uniprot id: C4LEH4
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

595494:TOLA RS01150
gene id: 595494:TOLA_RS01150
uniprot id: C4L8H5
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS05145
gene id: 595494:TOLA_RS05145
uniprot id: C4LCR2
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS03210
gene id: 595494:TOLA_RS03210
uniprot id: C4LAP6
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

595494:TOLA RS00965
gene id: 595494:TOLA_RS00965
uniprot id: C4L812
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

595494:TOLA RS14095
gene id: 595494:TOLA_RS14095
uniprot id: C4LBS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraA family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
messages: Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.

595494:TOLA RS07380
gene id: 595494:TOLA_RS07380
uniprot id: C4LEP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS10850
gene id: 595494:TOLA_RS10850
uniprot id: C4L888
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS02930
gene id: 595494:TOLA_RS02930
uniprot id: C4LA67
names: Subcellular Location Annotation
messages: Cytoplasm

595494:TOLA RS12860
gene id: 595494:TOLA_RS12860
uniprot id: C4LAE5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

595494:TOLA RS05570
gene id: 595494:TOLA_RS05570
uniprot id: C4LDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ProQ family.
messages: Cytoplasm
messages: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.

595494:TOLA RS15850
gene id: 595494:TOLA_RS15850
uniprot id: C4LDR6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

595494:TOLA RS02880
gene id: 595494:TOLA_RS02880
uniprot id: C4LA58
names: Similarity
messages: Belongs to the pirin family.

595494:TOLA RS15045
gene id: 595494:TOLA_RS15045
uniprot id: C4LCZ1
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

595494:TOLA RS04610
gene id: 595494:TOLA_RS04610
uniprot id: C4LC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

595494:TOLA RS14370
gene id: 595494:TOLA_RS14370
uniprot id: C4LBX2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

595494:TOLA RS10855
gene id: 595494:TOLA_RS10855
uniprot id: C4L889
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Homohexamer.

595494:TOLA RS12665
gene id: 595494:TOLA_RS12665
uniprot id: C4LAA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

595494:TOLA RS16100
gene id: 595494:TOLA_RS16100
uniprot id: C4LDW5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS15625
gene id: 595494:TOLA_RS15625
uniprot id: C4LDM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdgT transporter family.
messages: Catalyzes the proton-dependent uptake of 2-keto-3-deoxygluconate (KDG) into the cell.
messages: Cell inner membrane

595494:TOLA RS04150
gene id: 595494:TOLA_RS04150
uniprot id: C4LBK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

595494:TOLA RS14235
gene id: 595494:TOLA_RS14235
uniprot id: C4LBU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm

595494:TOLA RS09415
gene id: 595494:TOLA_RS09415
uniprot id: C4LFU6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS15340
gene id: 595494:TOLA_RS15340
uniprot id: C4LD46
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS11125
gene id: 595494:TOLA_RS11125
uniprot id: C4L8E4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

595494:TOLA RS11295
gene id: 595494:TOLA_RS11295
uniprot id: C4L8V3
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

595494:TOLA RS02410
gene id: 595494:TOLA_RS02410
uniprot id: C4L9W4
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

595494:TOLA RS00385
gene id: 595494:TOLA_RS00385
uniprot id: C4L7C6
names: Similarity
messages: Belongs to the VgrG protein family.

595494:TOLA RS13740
gene id: 595494:TOLA_RS13740
uniprot id: C4LBL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

595494:TOLA RS15160
gene id: 595494:TOLA_RS15160
uniprot id: C4LD14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

595494:TOLA RS05390
gene id: 595494:TOLA_RS05390
uniprot id: C4LCW2
names: Similarity
messages: Belongs to the UPF0229 family.

595494:TOLA RS07605
gene id: 595494:TOLA_RS07605
uniprot id: C4LET9
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

595494:TOLA RS00190
gene id: 595494:TOLA_RS00190
uniprot id: C4L786
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS13280
gene id: 595494:TOLA_RS13280
uniprot id: C4LB03
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

595494:TOLA RS11110
gene id: 595494:TOLA_RS11110
uniprot id: C4L8E1
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

595494:TOLA RS03415
gene id: 595494:TOLA_RS03415
uniprot id: C4LAT8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

595494:TOLA RS15955
gene id: 595494:TOLA_RS15955
uniprot id: C4LDT6
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

595494:TOLA RS06010
gene id: 595494:TOLA_RS06010
uniprot id: C4LDK1
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11930
gene id: 595494:TOLA_RS11930
uniprot id: C4L9J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS00620
gene id: 595494:TOLA_RS00620
uniprot id: C4L7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

595494:TOLA RS08920
gene id: 595494:TOLA_RS08920
uniprot id: C4LFJ8
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

595494:TOLA RS01975
gene id: 595494:TOLA_RS01975
uniprot id: C4L9A6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

595494:TOLA RS09140
gene id: 595494:TOLA_RS09140
uniprot id: C4LFP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

595494:TOLA RS15475
gene id: 595494:TOLA_RS15475
uniprot id: C4LD72
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

595494:TOLA RS08025
gene id: 595494:TOLA_RS08025
uniprot id: C4LF19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

595494:TOLA RS11045
gene id: 595494:TOLA_RS11045
uniprot id: C4L8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS00590
gene id: 595494:TOLA_RS00590
uniprot id: C4L7U4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

595494:TOLA RS14510
gene id: 595494:TOLA_RS14510
uniprot id: C4LCC0
names: Function
names: Similarity
messages: Belongs to the RlpA family.
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

595494:TOLA RS11120
gene id: 595494:TOLA_RS11120
uniprot id: C4L8E3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

595494:TOLA RS01445
gene id: 595494:TOLA_RS01445
uniprot id: C4L8N4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS11445
gene id: 595494:TOLA_RS11445
uniprot id: C4L8Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

595494:TOLA RS12995
gene id: 595494:TOLA_RS12995
uniprot id: C4LAH3
names: Cofactor
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN covalently per subunit.

595494:TOLA RS04000
gene id: 595494:TOLA_RS04000
uniprot id: C4LBH4
names: Similarity
messages: Belongs to the UPF0053 family.

595494:TOLA RS01260
gene id: 595494:TOLA_RS01260
uniprot id: C4L8J7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS13535
gene id: 595494:TOLA_RS13535
uniprot id: C4LB51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

595494:TOLA RS06990
gene id: 595494:TOLA_RS06990
uniprot id: C4LEG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

595494:TOLA RS00570
gene id: 595494:TOLA_RS00570
uniprot id: C4L7U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

595494:TOLA RS13240
gene id: 595494:TOLA_RS13240
uniprot id: C4LAZ5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

595494:TOLA RS00710
gene id: 595494:TOLA_RS00710
uniprot id: C4L7W8
names: Similarity
messages: Belongs to the leucine-binding protein family.

595494:TOLA RS09175
gene id: 595494:TOLA_RS09175
uniprot id: C4LFP8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

595494:TOLA RS04240
gene id: 595494:TOLA_RS04240
uniprot id: C4LBX7
names: Cofactor
names: Similarity
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.

595494:TOLA RS15405
gene id: 595494:TOLA_RS15405
uniprot id: C4LD59
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

595494:TOLA RS12045
gene id: 595494:TOLA_RS12045
uniprot id: C4L9L3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

595494:TOLA RS02350
gene id: 595494:TOLA_RS02350
uniprot id: C4L9V1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

595494:TOLA RS05150
gene id: 595494:TOLA_RS05150
uniprot id: C4LCR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

595494:TOLA RS11285
gene id: 595494:TOLA_RS11285
uniprot id: C4L8V1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism.

595494:TOLA RS12040
gene id: 595494:TOLA_RS12040
uniprot id: C4L9L2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

595494:TOLA RS14040
gene id: 595494:TOLA_RS14040
uniprot id: C4LBR6
names: Subcellular Location Annotation
messages: Cell inner membrane

595494:TOLA RS02390
gene id: 595494:TOLA_RS02390
uniprot id: C4L9W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS14020
gene id: 595494:TOLA_RS14020
uniprot id: C4LBR2
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

595494:TOLA RS13190
gene id: 595494:TOLA_RS13190
uniprot id: C4LAY5
names: Similarity
messages: Belongs to the Rsd/AlgQ family.

595494:TOLA RS04560
gene id: 595494:TOLA_RS04560
uniprot id: C4LC38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS08975
gene id: 595494:TOLA_RS08975
uniprot id: C4LFK9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS14520
gene id: 595494:TOLA_RS14520
uniprot id: C4LCC2
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

595494:TOLA RS12675
gene id: 595494:TOLA_RS12675
uniprot id: C4LAA8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

595494:TOLA RS13735
gene id: 595494:TOLA_RS13735
uniprot id: C4LB89
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

595494:TOLA RS06495
gene id: 595494:TOLA_RS06495
uniprot id: C4LE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

595494:TOLA RS13125
gene id: 595494:TOLA_RS13125
uniprot id: C4LAX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
messages: Homohexamer; trimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS12715
gene id: 595494:TOLA_RS12715
uniprot id: C4LAB6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

595494:TOLA RS06380
gene id: 595494:TOLA_RS06380
uniprot id: C4LE44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

595494:TOLA RS02820
gene id: 595494:TOLA_RS02820
uniprot id: C4LA47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

595494:TOLA RS01890
gene id: 595494:TOLA_RS01890
uniprot id: C4L989
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP M family.
messages: Cell inner membrane
messages: Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

595494:TOLA RS15100
gene id: 595494:TOLA_RS15100
uniprot id: C4LD02
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

595494:TOLA RS09615
gene id: 595494:TOLA_RS09615
uniprot id: C4LFX8
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

595494:TOLA RS05545
gene id: 595494:TOLA_RS05545
uniprot id: C4LDB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

595494:TOLA RS12830
gene id: 595494:TOLA_RS12830
uniprot id: C4LAD9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

595494:TOLA RS13705
gene id: 595494:TOLA_RS13705
uniprot id: C4LB83
names: Similarity
messages: Belongs to the asparaginase 1 family.

595494:TOLA RS14345
gene id: 595494:TOLA_RS14345
uniprot id: C4LBW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS05615
gene id: 595494:TOLA_RS05615
uniprot id: C4LDC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

595494:TOLA RS14205
gene id: 595494:TOLA_RS14205
uniprot id: C4LBU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

595494:TOLA RS07700
gene id: 595494:TOLA_RS07700
uniprot id: C4LEV7
names: Similarity
messages: Belongs to the MQO family.

595494:TOLA RS06105
gene id: 595494:TOLA_RS06105
uniprot id: C4LDL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell inner membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

595494:TOLA RS02610
gene id: 595494:TOLA_RS02610
uniprot id: C4LA04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

595494:TOLA RS12680
gene id: 595494:TOLA_RS12680
uniprot id: C4LAA9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

595494:TOLA RS14780
gene id: 595494:TOLA_RS14780
uniprot id: C4LCH2
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10015
gene id: 595494:TOLA_RS10015
uniprot id: C4L7F2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

595494:TOLA RS03170
gene id: 595494:TOLA_RS03170
uniprot id: C4LAN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

595494:TOLA RS07020
gene id: 595494:TOLA_RS07020
uniprot id: C4LEH3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS07760
gene id: 595494:TOLA_RS07760
uniprot id: C4LEW8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

595494:TOLA RS06285
gene id: 595494:TOLA_RS06285
uniprot id: C4LE26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

595494:TOLA RS10815
gene id: 595494:TOLA_RS10815
uniprot id: C4L881
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

595494:TOLA RS09650
gene id: 595494:TOLA_RS09650
uniprot id: C4LFY5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS06985
gene id: 595494:TOLA_RS06985
uniprot id: C4LEG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

595494:TOLA RS16665
gene id: 595494:TOLA_RS16665
uniprot id: C4LFC2
names: Similarity
messages: Belongs to the CobH/CbiC family.

595494:TOLA RS11530
gene id: 595494:TOLA_RS11530
uniprot id: C4L8Z8
names: Similarity
messages: Belongs to the HsdR family.

595494:TOLA RS08940
gene id: 595494:TOLA_RS08940
uniprot id: C4LFK2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

595494:TOLA RS11035
gene id: 595494:TOLA_RS11035
uniprot id: C4L8C6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

595494:TOLA RS12900
gene id: 595494:TOLA_RS12900
uniprot id: C4LAF3
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

595494:TOLA RS02835
gene id: 595494:TOLA_RS02835
uniprot id: C4LA49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

595494:TOLA RS04970
gene id: 595494:TOLA_RS04970
uniprot id: C4LCN0
names: Similarity
messages: Belongs to the GSP E family.

595494:TOLA RS04170
gene id: 595494:TOLA_RS04170
uniprot id: C4LBK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

595494:TOLA RS08440
gene id: 595494:TOLA_RS08440
uniprot id: C4LFA2
names: Similarity
messages: Belongs to the thioesterase PaaI family.

595494:TOLA RS13460
gene id: 595494:TOLA_RS13460
uniprot id: C4LB36
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

595494:TOLA RS10865
gene id: 595494:TOLA_RS10865
uniprot id: C4L891
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

595494:TOLA RS02425
gene id: 595494:TOLA_RS02425
uniprot id: C4L9W7
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS07790
gene id: 595494:TOLA_RS07790
uniprot id: C4LEX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

595494:TOLA RS10290
gene id: 595494:TOLA_RS10290
uniprot id: C4L7K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

595494:TOLA RS15060
gene id: 595494:TOLA_RS15060
uniprot id: C4LCZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

595494:TOLA RS16050
gene id: 595494:TOLA_RS16050
uniprot id: C4LDV5
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

595494:TOLA RS06175
gene id: 595494:TOLA_RS06175
uniprot id: C4LE04
names: Similarity
messages: Belongs to the thioesterase PaaI family.

595494:TOLA RS06940
gene id: 595494:TOLA_RS06940
uniprot id: C4LEF7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

595494:TOLA RS13575
gene id: 595494:TOLA_RS13575
uniprot id: C4LB59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

595494:TOLA RS15310
gene id: 595494:TOLA_RS15310
uniprot id: C4LD40
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

595494:TOLA RS00995
gene id: 595494:TOLA_RS00995
uniprot id: C4L818
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

595494:TOLA RS10550
gene id: 595494:TOLA_RS10550
uniprot id: C4L7Q9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

595494:TOLA RS14915
gene id: 595494:TOLA_RS14915
uniprot id: C4LCJ2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS01495
gene id: 595494:TOLA_RS01495
uniprot id: C4L8P4
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

595494:TOLA RS08980
gene id: 595494:TOLA_RS08980
uniprot id: C4LFL0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS05185
gene id: 595494:TOLA_RS05185
uniprot id: C4LCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS00215
gene id: 595494:TOLA_RS00215
uniprot id: C4L791
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
messages: Periplasm

595494:TOLA RS15095
gene id: 595494:TOLA_RS15095
uniprot id: C4LD01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

595494:TOLA RS01510
gene id: 595494:TOLA_RS01510
uniprot id: C4L8P6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS15320
gene id: 595494:TOLA_RS15320
uniprot id: C4LD42
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

595494:TOLA RS02910
gene id: 595494:TOLA_RS02910
uniprot id: C4LA63
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

595494:TOLA RS10870
gene id: 595494:TOLA_RS10870
uniprot id: C4L892
names: Similarity
messages: Belongs to the UPF0438 family.

595494:TOLA RS03705
gene id: 595494:TOLA_RS03705
uniprot id: C4LBB5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

595494:TOLA RS00440
gene id: 595494:TOLA_RS00440
uniprot id: C4L7R4
names: Similarity
messages: Belongs to the UPF0381 family.

595494:TOLA RS08245
gene id: 595494:TOLA_RS08245
uniprot id: C4LF63
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

595494:TOLA RS15185
gene id: 595494:TOLA_RS15185
uniprot id: C4LD19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS12835
gene id: 595494:TOLA_RS12835
uniprot id: C4LAE0
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

595494:TOLA RS06225
gene id: 595494:TOLA_RS06225
uniprot id: C4LE14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Part of a sulfur-relay system.

595494:TOLA RS14110
gene id: 595494:TOLA_RS14110
uniprot id: C4LBT0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

595494:TOLA RS08275
gene id: 595494:TOLA_RS08275
uniprot id: C4LF69
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS11025
gene id: 595494:TOLA_RS11025
uniprot id: C4L8C4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

595494:TOLA RS14495
gene id: 595494:TOLA_RS14495
uniprot id: C4LCB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

595494:TOLA RS00040
gene id: 595494:TOLA_RS00040
uniprot id: C4L762
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

595494:TOLA RS08775
gene id: 595494:TOLA_RS08775
uniprot id: C4LFG9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

595494:TOLA RS12115
gene id: 595494:TOLA_RS12115
uniprot id: C4L9M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

595494:TOLA RS13040
gene id: 595494:TOLA_RS13040
uniprot id: C4LAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

595494:TOLA RS10860
gene id: 595494:TOLA_RS10860
uniprot id: C4L890
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

595494:TOLA RS00225
gene id: 595494:TOLA_RS00225
uniprot id: C4L793
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS04490
gene id: 595494:TOLA_RS04490
uniprot id: C4LC24
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

595494:TOLA RS06445
gene id: 595494:TOLA_RS06445
uniprot id: C4LE57
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

595494:TOLA RS11050
gene id: 595494:TOLA_RS11050
uniprot id: C4L8C9
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

595494:TOLA RS03025
gene id: 595494:TOLA_RS03025
uniprot id: C4LAL1
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

595494:TOLA RS12155
gene id: 595494:TOLA_RS12155
uniprot id: C4L9N5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

595494:TOLA RS03060
gene id: 595494:TOLA_RS03060
uniprot id: C4LAL8
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS01870
gene id: 595494:TOLA_RS01870
uniprot id: C4L985
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

595494:TOLA RS14005
gene id: 595494:TOLA_RS14005
uniprot id: C4LBQ9
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

595494:TOLA RS08485
gene id: 595494:TOLA_RS08485
uniprot id: C4LFB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell inner membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

595494:TOLA RS02795
gene id: 595494:TOLA_RS02795
uniprot id: C4LA41
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

595494:TOLA RS07395
gene id: 595494:TOLA_RS07395
uniprot id: C4LEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS10260
gene id: 595494:TOLA_RS10260
uniprot id: C4L7K1
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

595494:TOLA RS02165
gene id: 595494:TOLA_RS02165
uniprot id: C4L9E4
names: Similarity
messages: Belongs to the class-I fumarase family.

595494:TOLA RS08870
gene id: 595494:TOLA_RS08870
uniprot id: C4LFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

595494:TOLA RS14230
gene id: 595494:TOLA_RS14230
uniprot id: C4LBU8
names: Similarity
messages: Belongs to the DsrF/TusC family.

595494:TOLA RS10785
gene id: 595494:TOLA_RS10785
uniprot id: C4L875
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

595494:TOLA RS03895
gene id: 595494:TOLA_RS03895
uniprot id: C4LBF2
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

595494:TOLA RS15970
gene id: 595494:TOLA_RS15970
uniprot id: C4LDT9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS05470
gene id: 595494:TOLA_RS05470
uniprot id: C4LCY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

595494:TOLA RS02300
gene id: 595494:TOLA_RS02300
uniprot id: C4L9H1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS08040
gene id: 595494:TOLA_RS08040
uniprot id: C4LF22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14840
gene id: 595494:TOLA_RS14840
uniprot id: C4LCI2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS08670
gene id: 595494:TOLA_RS08670
uniprot id: C4LFE8
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

595494:TOLA RS10670
gene id: 595494:TOLA_RS10670
uniprot id: C4L851
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

595494:TOLA RS11885
gene id: 595494:TOLA_RS11885
uniprot id: C4L9I2
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

595494:TOLA RS08925
gene id: 595494:TOLA_RS08925
uniprot id: C4LFJ9
names: Similarity
messages: Belongs to the MoaD family.

595494:TOLA RS11410
gene id: 595494:TOLA_RS11410
uniprot id: C4L8X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

595494:TOLA RS03020
gene id: 595494:TOLA_RS03020
uniprot id: C4LAL0
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

595494:TOLA RS02860
gene id: 595494:TOLA_RS02860
uniprot id: C4LA54
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS01650
gene id: 595494:TOLA_RS01650
uniprot id: C4L8S6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS12970
gene id: 595494:TOLA_RS12970
uniprot id: C4LAG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

595494:TOLA RS10705
gene id: 595494:TOLA_RS10705
uniprot id: C4L858
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

595494:TOLA RS00925
gene id: 595494:TOLA_RS00925
uniprot id: C4L804
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell inner membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

595494:TOLA RS12710
gene id: 595494:TOLA_RS12710
uniprot id: C4LAB5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS08010
gene id: 595494:TOLA_RS08010
uniprot id: C4LF16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS04940
gene id: 595494:TOLA_RS04940
uniprot id: C4LCM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

595494:TOLA RS10600
gene id: 595494:TOLA_RS10600
uniprot id: C4L839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS05560
gene id: 595494:TOLA_RS05560
uniprot id: C4LDB6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

595494:TOLA RS10510
gene id: 595494:TOLA_RS10510
uniprot id: C4L7Q1
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

595494:TOLA RS06315
gene id: 595494:TOLA_RS06315
uniprot id: C4LE32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS12705
gene id: 595494:TOLA_RS12705
uniprot id: C4LAB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS00750
gene id: 595494:TOLA_RS00750
uniprot id: C4L7X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

595494:TOLA RS10730
gene id: 595494:TOLA_RS10730
uniprot id: C4L863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

595494:TOLA RS04425
gene id: 595494:TOLA_RS04425
uniprot id: C4LC11
names: Similarity
messages: Belongs to the phosphohexose mutase family.

595494:TOLA RS00665
gene id: 595494:TOLA_RS00665
uniprot id: C4L7V9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

595494:TOLA RS00350
gene id: 595494:TOLA_RS00350
uniprot id: C4L7B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

595494:TOLA RS08225
gene id: 595494:TOLA_RS08225
uniprot id: C4LF59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

595494:TOLA RS02640
gene id: 595494:TOLA_RS02640
uniprot id: C4LA10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

595494:TOLA RS00645
gene id: 595494:TOLA_RS00645
uniprot id: C4L7V5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

595494:TOLA RS00520
gene id: 595494:TOLA_RS00520
uniprot id: C4L7T0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

595494:TOLA RS14765
gene id: 595494:TOLA_RS14765
uniprot id: C4LCG9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

595494:TOLA RS04265
gene id: 595494:TOLA_RS04265
uniprot id: C4LBY2
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS01280
gene id: 595494:TOLA_RS01280
uniprot id: C4L8K1
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

595494:TOLA RS04485
gene id: 595494:TOLA_RS04485
uniprot id: C4LC23
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS14970
gene id: 595494:TOLA_RS14970
uniprot id: C4LCK3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

595494:TOLA RS07920
gene id: 595494:TOLA_RS07920
uniprot id: C4LEZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

595494:TOLA RS11345
gene id: 595494:TOLA_RS11345
uniprot id: C4L8W3
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10840
gene id: 595494:TOLA_RS10840
uniprot id: C4L886
names: Similarity
messages: Belongs to the SlyX family.

595494:TOLA RS15155
gene id: 595494:TOLA_RS15155
uniprot id: C4LD13
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

595494:TOLA RS14055
gene id: 595494:TOLA_RS14055
uniprot id: C4LBR9
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

595494:TOLA RS15990
gene id: 595494:TOLA_RS15990
uniprot id: C4LDU3
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.

595494:TOLA RS07855
gene id: 595494:TOLA_RS07855
uniprot id: C4LEY7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

595494:TOLA RS00310
gene id: 595494:TOLA_RS00310
uniprot id: C4L7B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cell wall

595494:TOLA RS04770
gene id: 595494:TOLA_RS04770
uniprot id: C4LC78
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

595494:TOLA RS05090
gene id: 595494:TOLA_RS05090
uniprot id: C4LCQ1
names: Similarity
messages: Belongs to the DapB family.

595494:TOLA RS12165
gene id: 595494:TOLA_RS12165
uniprot id: C4L9N7
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.

595494:TOLA RS12535
gene id: 595494:TOLA_RS12535
uniprot id: C4LA83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

595494:TOLA RS13410
gene id: 595494:TOLA_RS13410
uniprot id: C4LB26
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

595494:TOLA RS12145
gene id: 595494:TOLA_RS12145
uniprot id: C4L9N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

595494:TOLA RS00555
gene id: 595494:TOLA_RS00555
uniprot id: C4L7T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

595494:TOLA RS15225
gene id: 595494:TOLA_RS15225
uniprot id: C4LD27
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

595494:TOLA RS04685
gene id: 595494:TOLA_RS04685
uniprot id: C4LC61
names: Function
names: Subunit
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.

595494:TOLA RS02305
gene id: 595494:TOLA_RS02305
uniprot id: C4L9H2
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

595494:TOLA RS09690
gene id: 595494:TOLA_RS09690
uniprot id: C4LFZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

595494:TOLA RS15175
gene id: 595494:TOLA_RS15175
uniprot id: C4LD17
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS06240
gene id: 595494:TOLA_RS06240
uniprot id: C4LE16
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

595494:TOLA RS10030
gene id: 595494:TOLA_RS10030
uniprot id: C4L7F5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14985
gene id: 595494:TOLA_RS14985
uniprot id: C4LCK6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

595494:TOLA RS09430
gene id: 595494:TOLA_RS09430
uniprot id: C4LFU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

595494:TOLA RS12545
gene id: 595494:TOLA_RS12545
uniprot id: C4LA85
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS03475
gene id: 595494:TOLA_RS03475
uniprot id: C4LAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

595494:TOLA RS14475
gene id: 595494:TOLA_RS14475
uniprot id: C4LCB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

595494:TOLA RS11140
gene id: 595494:TOLA_RS11140
uniprot id: C4L8E7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

595494:TOLA RS00485
gene id: 595494:TOLA_RS00485
uniprot id: C4L7S3
names: Function
names: Similarity
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

595494:TOLA RS11950
gene id: 595494:TOLA_RS11950
uniprot id: C4L9J6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS10625
gene id: 595494:TOLA_RS10625
uniprot id: C4L842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

595494:TOLA RS11875
gene id: 595494:TOLA_RS11875
uniprot id: C4L9I0
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

595494:TOLA RS12515
gene id: 595494:TOLA_RS12515
uniprot id: C4LA79
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10485
gene id: 595494:TOLA_RS10485
uniprot id: C4L7P6
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

595494:TOLA RS12085
gene id: 595494:TOLA_RS12085
uniprot id: C4L9M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS12685
gene id: 595494:TOLA_RS12685
uniprot id: C4LAB0
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

595494:TOLA RS04630
gene id: 595494:TOLA_RS04630
uniprot id: C4LC52
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

595494:TOLA RS08360
gene id: 595494:TOLA_RS08360
uniprot id: C4LF86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

595494:TOLA RS01220
gene id: 595494:TOLA_RS01220
uniprot id: C4L8I9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

595494:TOLA RS04925
gene id: 595494:TOLA_RS04925
uniprot id: C4LCM1
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

595494:TOLA RS00805
gene id: 595494:TOLA_RS00805
uniprot id: C4L7Y7
names: Similarity
messages: Belongs to the Smg family.

595494:TOLA RS09590
gene id: 595494:TOLA_RS09590
uniprot id: C4LFX3
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

595494:TOLA RS11795
gene id: 595494:TOLA_RS11795
uniprot id: C4L947
names: Similarity
messages: Belongs to the ClpA/ClpB family.

595494:TOLA RS11375
gene id: 595494:TOLA_RS11375
uniprot id: C4L8W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

595494:TOLA RS10415
gene id: 595494:TOLA_RS10415
uniprot id: C4L7N2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

595494:TOLA RS14760
gene id: 595494:TOLA_RS14760
uniprot id: C4LCG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

595494:TOLA RS03570
gene id: 595494:TOLA_RS03570
uniprot id: C4LAW9
names: Similarity
messages: Belongs to the Gfa family.

595494:TOLA RS14575
gene id: 595494:TOLA_RS14575
uniprot id: C4LCD2
names: Similarity
messages: Belongs to the YoeB family.

595494:TOLA RS01765
gene id: 595494:TOLA_RS01765
uniprot id: C4L966
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

595494:TOLA RS10885
gene id: 595494:TOLA_RS10885
uniprot id: C4L895
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

595494:TOLA RS02280
gene id: 595494:TOLA_RS02280
uniprot id: C4L9G7
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

595494:TOLA RS08240
gene id: 595494:TOLA_RS08240
uniprot id: C4LF62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

595494:TOLA RS02415
gene id: 595494:TOLA_RS02415
uniprot id: C4L9W5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS05600
gene id: 595494:TOLA_RS05600
uniprot id: C4LDC4
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

595494:TOLA RS13515
gene id: 595494:TOLA_RS13515
uniprot id: C4LB47
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS12825
gene id: 595494:TOLA_RS12825
uniprot id: C4LAD8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

595494:TOLA RS00885
gene id: 595494:TOLA_RS00885
uniprot id: C4L7Z6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS05670
gene id: 595494:TOLA_RS05670
uniprot id: C4LDD8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS09280
gene id: 595494:TOLA_RS09280
uniprot id: C4LFR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

595494:TOLA RS13210
gene id: 595494:TOLA_RS13210
uniprot id: C4LAY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

595494:TOLA RS08645
gene id: 595494:TOLA_RS08645
uniprot id: C4LFE3
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

595494:TOLA RS12940
gene id: 595494:TOLA_RS12940
uniprot id: C4LAG2
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

595494:TOLA RS08935
gene id: 595494:TOLA_RS08935
uniprot id: C4LFK1
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

595494:TOLA RS13915
gene id: 595494:TOLA_RS13915
uniprot id: C4LBP6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

595494:TOLA RS14715
gene id: 595494:TOLA_RS14715
uniprot id: C4LCF9
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

595494:TOLA RS03295
gene id: 595494:TOLA_RS03295
uniprot id: C4LAR3
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

595494:TOLA RS01490
gene id: 595494:TOLA_RS01490
uniprot id: C4L8P3
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Membrane

595494:TOLA RS01140
gene id: 595494:TOLA_RS01140
uniprot id: C4L8H3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

595494:TOLA RS11130
gene id: 595494:TOLA_RS11130
uniprot id: C4L8E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

595494:TOLA RS12510
gene id: 595494:TOLA_RS12510
uniprot id: C4LA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

595494:TOLA RS12700
gene id: 595494:TOLA_RS12700
uniprot id: C4LAB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

595494:TOLA RS07375
gene id: 595494:TOLA_RS07375
uniprot id: C4LEP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

595494:TOLA RS10770
gene id: 595494:TOLA_RS10770
uniprot id: C4L872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS11220
gene id: 595494:TOLA_RS11220
uniprot id: C4L8T9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS15200
gene id: 595494:TOLA_RS15200
uniprot id: C4LD22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

595494:TOLA RS07485
gene id: 595494:TOLA_RS07485
uniprot id: C4LER5
names: Similarity
messages: Belongs to the BMP lipoprotein family.

595494:TOLA RS14335
gene id: 595494:TOLA_RS14335
uniprot id: C4LBW6
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

595494:TOLA RS13400
gene id: 595494:TOLA_RS13400
uniprot id: C4LB24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

595494:TOLA RS02710
gene id: 595494:TOLA_RS02710
uniprot id: C4LA23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

595494:TOLA RS07580
gene id: 595494:TOLA_RS07580
uniprot id: C4LET4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

595494:TOLA RS10215
gene id: 595494:TOLA_RS10215
uniprot id: C4L7J2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS15440
gene id: 595494:TOLA_RS15440
uniprot id: C4LD65
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS02025
gene id: 595494:TOLA_RS02025
uniprot id: C4L9B6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS04690
gene id: 595494:TOLA_RS04690
uniprot id: C4LC62
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

595494:TOLA RS15835
gene id: 595494:TOLA_RS15835
uniprot id: C4LDR3
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

595494:TOLA RS14740
gene id: 595494:TOLA_RS14740
uniprot id: C4LCG4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS05080
gene id: 595494:TOLA_RS05080
uniprot id: C4LCP9
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

595494:TOLA RS04575
gene id: 595494:TOLA_RS04575
uniprot id: C4LC41
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

595494:TOLA RS03005
gene id: 595494:TOLA_RS03005
uniprot id: C4LAK7
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

595494:TOLA RS11290
gene id: 595494:TOLA_RS11290
uniprot id: C4L8V2
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

595494:TOLA RS09350
gene id: 595494:TOLA_RS09350
uniprot id: C4LFT3
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS02970
gene id: 595494:TOLA_RS02970
uniprot id: C4LAK0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

595494:TOLA RS00595
gene id: 595494:TOLA_RS00595
uniprot id: C4L7U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

595494:TOLA RS10575
gene id: 595494:TOLA_RS10575
uniprot id: C4L834
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10610
gene id: 595494:TOLA_RS10610
uniprot id: C4L841
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS08825
gene id: 595494:TOLA_RS08825
uniprot id: C4LFH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

595494:TOLA RS02630
gene id: 595494:TOLA_RS02630
uniprot id: C4LA08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

595494:TOLA RS10425
gene id: 595494:TOLA_RS10425
uniprot id: C4L7N4
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

595494:TOLA RS01760
gene id: 595494:TOLA_RS01760
uniprot id: C4L964
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

595494:TOLA RS10710
gene id: 595494:TOLA_RS10710
uniprot id: C4L859
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

595494:TOLA RS02760
gene id: 595494:TOLA_RS02760
uniprot id: C4LA34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

595494:TOLA RS01350
gene id: 595494:TOLA_RS01350
uniprot id: C4L8L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

595494:TOLA RS14270
gene id: 595494:TOLA_RS14270
uniprot id: C4LBV6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

595494:TOLA RS10835
gene id: 595494:TOLA_RS10835
uniprot id: C4L885
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

595494:TOLA RS15825
gene id: 595494:TOLA_RS15825
uniprot id: C4LDR1
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

595494:TOLA RS11700
gene id: 595494:TOLA_RS11700
uniprot id: C4L933
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

595494:TOLA RS13030
gene id: 595494:TOLA_RS13030
uniprot id: C4LAI0
names: Similarity
messages: Belongs to the UPF0231 family.

595494:TOLA RS12880
gene id: 595494:TOLA_RS12880
uniprot id: C4LAE9
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

595494:TOLA RS00425
gene id: 595494:TOLA_RS00425
uniprot id: C4L7D4
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

595494:TOLA RS02260
gene id: 595494:TOLA_RS02260
uniprot id: C4L9G3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

595494:TOLA RS00605
gene id: 595494:TOLA_RS00605
uniprot id: C4L7U7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

595494:TOLA RS00475
gene id: 595494:TOLA_RS00475
uniprot id: C4L7S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PagL family.
messages: Cell outer membrane
messages: Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety.
messages: Homodimer.

595494:TOLA RS10320
gene id: 595494:TOLA_RS10320
uniprot id: C4L7L3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

595494:TOLA RS07180
gene id: 595494:TOLA_RS07180
uniprot id: C4LEK3
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS12785
gene id: 595494:TOLA_RS12785
uniprot id: C4LAD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS09780
gene id: 595494:TOLA_RS09780
uniprot id: C4LG06
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

595494:TOLA RS00315
gene id: 595494:TOLA_RS00315
uniprot id: C4L7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

595494:TOLA RS02775
gene id: 595494:TOLA_RS02775
uniprot id: C4LA37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS14605
gene id: 595494:TOLA_RS14605
uniprot id: C4LCD8
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

595494:TOLA RS01985
gene id: 595494:TOLA_RS01985
uniprot id: C4L9A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
messages: Cell outer membrane
messages: Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.

595494:TOLA RS11750
gene id: 595494:TOLA_RS11750
uniprot id: C4L938
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

595494:TOLA RS07845
gene id: 595494:TOLA_RS07845
uniprot id: C4LEY5
names: Similarity
messages: Belongs to the UPF0227 family.

595494:TOLA RS16250
gene id: 595494:TOLA_RS16250
uniprot id: C4LEB8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

595494:TOLA RS13260
gene id: 595494:TOLA_RS13260
uniprot id: C4LAZ9
names: Cofactor
names: Similarity
messages: Belongs to the cytochrome b562 family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.

595494:TOLA RS07955
gene id: 595494:TOLA_RS07955
uniprot id: C4LF05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

595494:TOLA RS07015
gene id: 595494:TOLA_RS07015
uniprot id: C4LEH2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS15105
gene id: 595494:TOLA_RS15105
uniprot id: C4LD03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

595494:TOLA RS02265
gene id: 595494:TOLA_RS02265
uniprot id: C4L9G4
names: Function
names: Similarity
messages: Belongs to the isochorismate synthase family.
messages: Catalyzes the conversion of chorismate to isochorismate.

595494:TOLA RS16215
gene id: 595494:TOLA_RS16215
uniprot id: C4LDY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS04750
gene id: 595494:TOLA_RS04750
uniprot id: C4LC74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

595494:TOLA RS05255
gene id: 595494:TOLA_RS05255
uniprot id: C4LCT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

595494:TOLA RS06440
gene id: 595494:TOLA_RS06440
uniprot id: C4LE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

595494:TOLA RS13195
gene id: 595494:TOLA_RS13195
uniprot id: C4LAY6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

595494:TOLA RS13290
gene id: 595494:TOLA_RS13290
uniprot id: C4LB05
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

595494:TOLA RS07365
gene id: 595494:TOLA_RS07365
uniprot id: C4LEP1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

595494:TOLA RS04380
gene id: 595494:TOLA_RS04380
uniprot id: C4LC02
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

595494:TOLA RS04980
gene id: 595494:TOLA_RS04980
uniprot id: C4LCN2
names: Similarity
messages: Belongs to the UPF0246 family.

595494:TOLA RS00445
gene id: 595494:TOLA_RS00445
uniprot id: C4L7R5
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

595494:TOLA RS02450
gene id: 595494:TOLA_RS02450
uniprot id: C4L9X2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

595494:TOLA RS12745
gene id: 595494:TOLA_RS12745
uniprot id: C4LAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

595494:TOLA RS07005
gene id: 595494:TOLA_RS07005
uniprot id: C4LEH0
names: Similarity
messages: Belongs to the BMP lipoprotein family.

595494:TOLA RS16090
gene id: 595494:TOLA_RS16090
uniprot id: C4LDW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

595494:TOLA RS02460
gene id: 595494:TOLA_RS02460
uniprot id: C4L9X4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

595494:TOLA RS13395
gene id: 595494:TOLA_RS13395
uniprot id: C4LB23
names: Similarity
messages: Belongs to the aldose epimerase family.

595494:TOLA RS05275
gene id: 595494:TOLA_RS05275
uniprot id: C4LCT8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

595494:TOLA RS11275
gene id: 595494:TOLA_RS11275
uniprot id: C4L8U9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

595494:TOLA RS15255
gene id: 595494:TOLA_RS15255
uniprot id: C4LD29
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

595494:TOLA RS10700
gene id: 595494:TOLA_RS10700
uniprot id: C4L857
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

595494:TOLA RS11385
gene id: 595494:TOLA_RS11385
uniprot id: C4L8X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

595494:TOLA RS11495
gene id: 595494:TOLA_RS11495
uniprot id: C4L8Z1
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

595494:TOLA RS05910
gene id: 595494:TOLA_RS05910
uniprot id: C4LDI1
names: Similarity
messages: Belongs to the HsdR family.

595494:TOLA RS04075
gene id: 595494:TOLA_RS04075
uniprot id: C4LBI9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS14725
gene id: 595494:TOLA_RS14725
uniprot id: C4LCG1
names: Similarity
messages: Belongs to the CcdB toxin family.

595494:TOLA RS12110
gene id: 595494:TOLA_RS12110
uniprot id: C4L9M6
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

595494:TOLA RS06435
gene id: 595494:TOLA_RS06435
uniprot id: C4LE55
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS13080
gene id: 595494:TOLA_RS13080
uniprot id: C4LAJ1
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

595494:TOLA RS13505
gene id: 595494:TOLA_RS13505
uniprot id: C4LB45
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

595494:TOLA RS11710
gene id: 595494:TOLA_RS11710
uniprot id: C4L935
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

595494:TOLA RS10465
gene id: 595494:TOLA_RS10465
uniprot id: C4L7P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

595494:TOLA RS07515
gene id: 595494:TOLA_RS07515
uniprot id: C4LES1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane

595494:TOLA RS04525
gene id: 595494:TOLA_RS04525
uniprot id: C4LC31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

595494:TOLA RS02205
gene id: 595494:TOLA_RS02205
uniprot id: C4L9F2
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

595494:TOLA RS10500
gene id: 595494:TOLA_RS10500
uniprot id: C4L7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

595494:TOLA RS14070
gene id: 595494:TOLA_RS14070
uniprot id: C4LBS2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

595494:TOLA RS14955
gene id: 595494:TOLA_RS14955
uniprot id: C4LCK0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

595494:TOLA RS13135
gene id: 595494:TOLA_RS13135
uniprot id: C4LAX4
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.

595494:TOLA RS02765
gene id: 595494:TOLA_RS02765
uniprot id: C4LA35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

595494:TOLA RS15645
gene id: 595494:TOLA_RS15645
uniprot id: C4LDM5
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

595494:TOLA RS15190
gene id: 595494:TOLA_RS15190
uniprot id: C4LD20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

595494:TOLA RS03265
gene id: 595494:TOLA_RS03265
uniprot id: C4LAQ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

595494:TOLA RS11320
gene id: 595494:TOLA_RS11320
uniprot id: C4L8V8
names: Similarity
messages: Belongs to the citrate synthase family.

595494:TOLA RS11965
gene id: 595494:TOLA_RS11965
uniprot id: C4L9J9
names: Cofactor
names: Function
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.

595494:TOLA RS13495
gene id: 595494:TOLA_RS13495
uniprot id: C4LB43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

595494:TOLA RS13110
gene id: 595494:TOLA_RS13110
uniprot id: C4LAJ7
names: Similarity
messages: Belongs to the CdaR family.

595494:TOLA RS07585
gene id: 595494:TOLA_RS07585
uniprot id: C4LET5
names: Similarity
messages: Belongs to the TonB-dependent receptor family.

595494:TOLA RS15385
gene id: 595494:TOLA_RS15385
uniprot id: C4LD55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

595494:TOLA RS14870
gene id: 595494:TOLA_RS14870
uniprot id: C4LCI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

595494:TOLA RS01570
gene id: 595494:TOLA_RS01570
uniprot id: C4L8Q8
names: Similarity
messages: Belongs to the ModE family.

595494:TOLA RS10695
gene id: 595494:TOLA_RS10695
uniprot id: C4L856
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

595494:TOLA RS15530
gene id: 595494:TOLA_RS15530
uniprot id: C4LD83
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

595494:TOLA RS02075
gene id: 595494:TOLA_RS02075
uniprot id: C4L9C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

595494:TOLA RS08820
gene id: 595494:TOLA_RS08820
uniprot id: C4LFH8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

595494:TOLA RS02650
gene id: 595494:TOLA_RS02650
uniprot id: C4LA12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS05605
gene id: 595494:TOLA_RS05605
uniprot id: C4LDC5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

595494:TOLA RS10980
gene id: 595494:TOLA_RS10980
uniprot id: C4L8B5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.

595494:TOLA RS14275
gene id: 595494:TOLA_RS14275
uniprot id: C4LBV7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

595494:TOLA RS06845
gene id: 595494:TOLA_RS06845
uniprot id: C4LEE0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

595494:TOLA RS13675
gene id: 595494:TOLA_RS13675
uniprot id: C4LB77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

595494:TOLA RS03370
gene id: 595494:TOLA_RS03370
uniprot id: C4LAS9
names: Similarity
messages: Belongs to the NifX/NifY family.

595494:TOLA RS05785
gene id: 595494:TOLA_RS05785
uniprot id: C4LDF6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

595494:TOLA RS08780
gene id: 595494:TOLA_RS08780
uniprot id: C4LFH0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

595494:TOLA RS14380
gene id: 595494:TOLA_RS14380
uniprot id: C4LBX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

595494:TOLA RS05305
gene id: 595494:TOLA_RS05305
uniprot id: C4LCU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane

595494:TOLA RS06295
gene id: 595494:TOLA_RS06295
uniprot id: C4LE28
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

595494:TOLA RS16190
gene id: 595494:TOLA_RS16190
uniprot id: C4LDY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

595494:TOLA RS01145
gene id: 595494:TOLA_RS01145
uniprot id: C4L8H4
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS00060
gene id: 595494:TOLA_RS00060
uniprot id: C4L766
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

595494:TOLA RS04145
gene id: 595494:TOLA_RS04145
uniprot id: C4LBK2
names: Function
names: Similarity
messages: Belongs to the FrsA family.
messages: Catalyzes the hydrolysis of esters.

595494:TOLA RS11370
gene id: 595494:TOLA_RS11370
uniprot id: C4L8W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

595494:TOLA RS13485
gene id: 595494:TOLA_RS13485
uniprot id: C4LB41
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS07225
gene id: 595494:TOLA_RS07225
uniprot id: C4LEL2
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

595494:TOLA RS00790
gene id: 595494:TOLA_RS00790
uniprot id: C4L7Y4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

595494:TOLA RS00450
gene id: 595494:TOLA_RS00450
uniprot id: C4L7R6
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS06570
gene id: 595494:TOLA_RS06570
uniprot id: C4LE82
names: Similarity
messages: Belongs to the pyruvate kinase family.

595494:TOLA RS12945
gene id: 595494:TOLA_RS12945
uniprot id: C4LAG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

595494:TOLA RS14015
gene id: 595494:TOLA_RS14015
uniprot id: C4LBR1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

595494:TOLA RS13155
gene id: 595494:TOLA_RS13155
uniprot id: C4LAX8
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

595494:TOLA RS07310
gene id: 595494:TOLA_RS07310
uniprot id: C4LEN0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

595494:TOLA RS00580
gene id: 595494:TOLA_RS00580
uniprot id: C4L7U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

595494:TOLA RS03435
gene id: 595494:TOLA_RS03435
uniprot id: C4LAU2
names: Similarity
messages: Belongs to the PhoH family.

595494:TOLA RS03340
gene id: 595494:TOLA_RS03340
uniprot id: C4LAS2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

595494:TOLA RS00090
gene id: 595494:TOLA_RS00090
uniprot id: C4L772
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Sulfur carrier protein which probably makes part of a sulfur-relay system.

595494:TOLA RS02745
gene id: 595494:TOLA_RS02745
uniprot id: C4LA30
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

595494:TOLA RS07720
gene id: 595494:TOLA_RS07720
uniprot id: C4LEW1
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

595494:TOLA RS08455
gene id: 595494:TOLA_RS08455
uniprot id: C4LFA5
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

595494:TOLA RS14215
gene id: 595494:TOLA_RS14215
uniprot id: C4LBU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

595494:TOLA RS11310
gene id: 595494:TOLA_RS11310
uniprot id: C4L8V6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

595494:TOLA RS04370
gene id: 595494:TOLA_RS04370
uniprot id: C4LC00
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

595494:TOLA RS10060
gene id: 595494:TOLA_RS10060
uniprot id: C4L7G1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS15260
gene id: 595494:TOLA_RS15260
uniprot id: C4LD30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

595494:TOLA RS13200
gene id: 595494:TOLA_RS13200
uniprot id: C4LAY7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

595494:TOLA RS13585
gene id: 595494:TOLA_RS13585
uniprot id: C4LB61
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

595494:TOLA RS11200
gene id: 595494:TOLA_RS11200
uniprot id: C4L8F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
messages: Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A.
messages: Cell inner membrane

595494:TOLA RS11790
gene id: 595494:TOLA_RS11790
uniprot id: C4L946
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

595494:TOLA RS05020
gene id: 595494:TOLA_RS05020
uniprot id: C4LCP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS05410
gene id: 595494:TOLA_RS05410
uniprot id: C4LCW7
names: Similarity
messages: Belongs to the DEAD box helicase family.

595494:TOLA RS04995
gene id: 595494:TOLA_RS04995
uniprot id: C4LCN5
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

595494:TOLA RS12135
gene id: 595494:TOLA_RS12135
uniprot id: C4L9N1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

595494:TOLA RS07000
gene id: 595494:TOLA_RS07000
uniprot id: C4LEG9
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS10725
gene id: 595494:TOLA_RS10725
uniprot id: C4L862
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS05610
gene id: 595494:TOLA_RS05610
uniprot id: C4LDC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

595494:TOLA RS01465
gene id: 595494:TOLA_RS01465
uniprot id: C4L8N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Membrane

595494:TOLA RS09915
gene id: 595494:TOLA_RS09915
uniprot id: C4LG31
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

595494:TOLA RS01340
gene id: 595494:TOLA_RS01340
uniprot id: C4L8L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

595494:TOLA RS11250
gene id: 595494:TOLA_RS11250
uniprot id: C4L8U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

595494:TOLA RS04205
gene id: 595494:TOLA_RS04205
uniprot id: C4LBL4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

595494:TOLA RS01705
gene id: 595494:TOLA_RS01705
uniprot id: C4L8T7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS13025
gene id: 595494:TOLA_RS13025
uniprot id: C4LAH9
names: Similarity
messages: Belongs to the P(II) protein family.

595494:TOLA RS02475
gene id: 595494:TOLA_RS02475
uniprot id: C4L9X7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

595494:TOLA RS04155
gene id: 595494:TOLA_RS04155
uniprot id: C4LBK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

595494:TOLA RS13945
gene id: 595494:TOLA_RS13945
uniprot id: C4LBP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

595494:TOLA RS15300
gene id: 595494:TOLA_RS15300
uniprot id: C4LD38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

595494:TOLA RS03970
gene id: 595494:TOLA_RS03970
uniprot id: C4LBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Membrane

595494:TOLA RS04325
gene id: 595494:TOLA_RS04325
uniprot id: C4LBZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

595494:TOLA RS03030
gene id: 595494:TOLA_RS03030
uniprot id: C4LAL2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

595494:TOLA RS10445
gene id: 595494:TOLA_RS10445
uniprot id: C4L7N8
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS07670
gene id: 595494:TOLA_RS07670
uniprot id: C4LEV2
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

595494:TOLA RS13480
gene id: 595494:TOLA_RS13480
uniprot id: C4LB40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

595494:TOLA RS13790
gene id: 595494:TOLA_RS13790
uniprot id: C4LBM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

595494:TOLA RS06040
gene id: 595494:TOLA_RS06040
uniprot id: C4LDK7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

595494:TOLA RS07510
gene id: 595494:TOLA_RS07510
uniprot id: C4LES0
names: Subcellular Location Annotation
messages: Membrane

595494:TOLA RS15010
gene id: 595494:TOLA_RS15010
uniprot id: C4LCY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

595494:TOLA RS09510
gene id: 595494:TOLA_RS09510
uniprot id: C4L8K5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

595494:TOLA RS11230
gene id: 595494:TOLA_RS11230
uniprot id: C4L8U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

595494:TOLA RS16105
gene id: 595494:TOLA_RS16105
uniprot id: C4LDW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

595494:TOLA RS14130
gene id: 595494:TOLA_RS14130
uniprot id: C4LBT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

595494:TOLA RS03090
gene id: 595494:TOLA_RS03090
uniprot id: C4LAM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

595494:TOLA RS09045
gene id: 595494:TOLA_RS09045
uniprot id: C4LFM3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

595494:TOLA RS04680
gene id: 595494:TOLA_RS04680
uniprot id: C4LC60
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

595494:TOLA RS12105
gene id: 595494:TOLA_RS12105
uniprot id: C4L9M5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

595494:TOLA RS01750
gene id: 595494:TOLA_RS01750
uniprot id: C4L962
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell inner membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.

595494:TOLA RS09220
gene id: 595494:TOLA_RS09220
uniprot id: C4LFQ7
names: Similarity
messages: Belongs to the nitroreductase family.

595494:TOLA RS07830
gene id: 595494:TOLA_RS07830
uniprot id: C4LEY2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

595494:TOLA RS05160
gene id: 595494:TOLA_RS05160
uniprot id: C4LCR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

595494:TOLA RS09335
gene id: 595494:TOLA_RS09335
uniprot id: C4LFT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

595494:TOLA RS13700
gene id: 595494:TOLA_RS13700
uniprot id: C4LB82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S49 family.
messages: Cell inner membrane