593750:METFOR RS10795
gene id: 593750:METFOR_RS10795
uniprot id: L0HHH3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03900
gene id: 593750:METFOR_RS03900
uniprot id: L0HEU9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

593750:METFOR RS13065
gene id: 593750:METFOR_RS13065
uniprot id: L0HG25
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

593750:METFOR RS06490
gene id: 593750:METFOR_RS06490
uniprot id: L0HC86
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

593750:METFOR RS00990
gene id: 593750:METFOR_RS00990
uniprot id: L0HDW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

593750:METFOR RS05185
gene id: 593750:METFOR_RS05185
uniprot id: L0HDJ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12285
gene id: 593750:METFOR_RS12285
uniprot id: L0HJL9
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS05845
gene id: 593750:METFOR_RS05845
uniprot id: L0HBW7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02140
gene id: 593750:METFOR_RS02140
uniprot id: L0HEG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS07010
gene id: 593750:METFOR_RS07010
uniprot id: L0HCI8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

593750:METFOR RS11820
gene id: 593750:METFOR_RS11820
uniprot id: L0HHB2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01560
gene id: 593750:METFOR_RS01560
uniprot id: L0HE69
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593750:METFOR RS10360
gene id: 593750:METFOR_RS10360
uniprot id: L0HGI5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS10070
gene id: 593750:METFOR_RS10070
uniprot id: L0HGC6
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

593750:METFOR RS07495
gene id: 593750:METFOR_RS07495
uniprot id: L0HFH7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

593750:METFOR RS12015
gene id: 593750:METFOR_RS12015
uniprot id: L0HHE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

593750:METFOR RS03505
gene id: 593750:METFOR_RS03505
uniprot id: L0HAK1
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

593750:METFOR RS12625
gene id: 593750:METFOR_RS12625
uniprot id: L0HHS4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS12745
gene id: 593750:METFOR_RS12745
uniprot id: L0HIK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

593750:METFOR RS05830
gene id: 593750:METFOR_RS05830
uniprot id: L0HGM7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13335
gene id: 593750:METFOR_RS13335
uniprot id: L0HK84
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

593750:METFOR RS12645
gene id: 593750:METFOR_RS12645
uniprot id: L0HKJ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

593750:METFOR RS03360
gene id: 593750:METFOR_RS03360
uniprot id: L0HAH4
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04595
gene id: 593750:METFOR_RS04595
uniprot id: L0HDV7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

593750:METFOR RS02500
gene id: 593750:METFOR_RS02500
uniprot id: L0HEN6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

593750:METFOR RS13610
gene id: 593750:METFOR_RS13610
uniprot id: L0HGC1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

593750:METFOR RS03580
gene id: 593750:METFOR_RS03580
uniprot id: L0HAL4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

593750:METFOR RS00890
gene id: 593750:METFOR_RS00890
uniprot id: L0HD67
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

593750:METFOR RS13995
gene id: 593750:METFOR_RS13995
uniprot id: L0HJ94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

593750:METFOR RS08440
gene id: 593750:METFOR_RS08440
uniprot id: L0HI52
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

593750:METFOR RS02395
gene id: 593750:METFOR_RS02395
uniprot id: L0HBZ0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12085
gene id: 593750:METFOR_RS12085
uniprot id: L0HHF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

593750:METFOR RS10510
gene id: 593750:METFOR_RS10510
uniprot id: L0HJB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

593750:METFOR RS13905
gene id: 593750:METFOR_RS13905
uniprot id: L0HKI2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

593750:METFOR RS14000
gene id: 593750:METFOR_RS14000
uniprot id: L0HGI3
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

593750:METFOR RS04970
gene id: 593750:METFOR_RS04970
uniprot id: L0HG24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

593750:METFOR RS03310
gene id: 593750:METFOR_RS03310
uniprot id: L0HAG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

593750:METFOR RS07845
gene id: 593750:METFOR_RS07845
uniprot id: L0HHS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

593750:METFOR RS06655
gene id: 593750:METFOR_RS06655
uniprot id: L0HGD6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS13745
gene id: 593750:METFOR_RS13745
uniprot id: L0HJ49
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

593750:METFOR RS01675
gene id: 593750:METFOR_RS01675
uniprot id: L0H9J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

593750:METFOR RS06075
gene id: 593750:METFOR_RS06075
uniprot id: L0HER6
names: Similarity
messages: Belongs to the glutamate synthase family.

593750:METFOR RS04360
gene id: 593750:METFOR_RS04360
uniprot id: L0HFR7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

593750:METFOR RS10925
gene id: 593750:METFOR_RS10925
uniprot id: L0HEU5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

593750:METFOR RS02095
gene id: 593750:METFOR_RS02095
uniprot id: L0HBS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

593750:METFOR RS02475
gene id: 593750:METFOR_RS02475
uniprot id: L0HEM8
names: Similarity
messages: Belongs to the MEMO1 family.

593750:METFOR RS14200
gene id: 593750:METFOR_RS14200
uniprot id: L0HJC6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593750:METFOR RS09645
gene id: 593750:METFOR_RS09645
uniprot id: L0HG32
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

593750:METFOR RS07235
gene id: 593750:METFOR_RS07235
uniprot id: L0HFC5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

593750:METFOR RS05410
gene id: 593750:METFOR_RS05410
uniprot id: L0HGC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593750:METFOR RS01980
gene id: 593750:METFOR_RS01980
uniprot id: L0H9P0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

593750:METFOR RS07760
gene id: 593750:METFOR_RS07760
uniprot id: L0HF08
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593750:METFOR RS04985
gene id: 593750:METFOR_RS04985
uniprot id: L0HBC8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

593750:METFOR RS02135
gene id: 593750:METFOR_RS02135
uniprot id: L0HDU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

593750:METFOR RS11745
gene id: 593750:METFOR_RS11745
uniprot id: L0HF88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593750:METFOR RS11165
gene id: 593750:METFOR_RS11165
uniprot id: L0HJ08
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

593750:METFOR RS13860
gene id: 593750:METFOR_RS13860
uniprot id: L0HL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

593750:METFOR RS03395
gene id: 593750:METFOR_RS03395
uniprot id: L0HF82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593750:METFOR RS04750
gene id: 593750:METFOR_RS04750
uniprot id: L0HFB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS06575
gene id: 593750:METFOR_RS06575
uniprot id: L0HF01
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

593750:METFOR RS12915
gene id: 593750:METFOR_RS12915
uniprot id: L0HHY2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

593750:METFOR RS05540
gene id: 593750:METFOR_RS05540
uniprot id: L0HDU7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

593750:METFOR RS06730
gene id: 593750:METFOR_RS06730
uniprot id: L0HGF1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS08620
gene id: 593750:METFOR_RS08620
uniprot id: L0HFK3
names: Similarity
messages: Belongs to the HypE family.

593750:METFOR RS05450
gene id: 593750:METFOR_RS05450
uniprot id: L0HBL5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

593750:METFOR RS00420
gene id: 593750:METFOR_RS00420
uniprot id: L0HDM3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

593750:METFOR RS11040
gene id: 593750:METFOR_RS11040
uniprot id: L0HGY2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12870
gene id: 593750:METFOR_RS12870
uniprot id: L0HIM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

593750:METFOR RS13915
gene id: 593750:METFOR_RS13915
uniprot id: L0HII0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

593750:METFOR RS06875
gene id: 593750:METFOR_RS06875
uniprot id: L0HH69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

593750:METFOR RS09220
gene id: 593750:METFOR_RS09220
uniprot id: L0HHU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

593750:METFOR RS05010
gene id: 593750:METFOR_RS05010
uniprot id: L0HBD3
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

593750:METFOR RS02090
gene id: 593750:METFOR_RS02090
uniprot id: L0HEF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

593750:METFOR RS13930
gene id: 593750:METFOR_RS13930
uniprot id: L0HKI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

593750:METFOR RS08060
gene id: 593750:METFOR_RS08060
uniprot id: L0HD87
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

593750:METFOR RS02595
gene id: 593750:METFOR_RS02595
uniprot id: L0HE42
names: Similarity
messages: Belongs to the SAICAR synthetase family.

593750:METFOR RS09020
gene id: 593750:METFOR_RS09020
uniprot id: L0HFS1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

593750:METFOR RS07975
gene id: 593750:METFOR_RS07975
uniprot id: L0HF73
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

593750:METFOR RS12605
gene id: 593750:METFOR_RS12605
uniprot id: L0HIG9
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03470
gene id: 593750:METFOR_RS03470
uniprot id: L0HCL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS06410
gene id: 593750:METFOR_RS06410
uniprot id: L0HEX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

593750:METFOR RS08490
gene id: 593750:METFOR_RS08490
uniprot id: L0HI60
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

593750:METFOR RS02105
gene id: 593750:METFOR_RS02105
uniprot id: L0H9R5
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

593750:METFOR RS03475
gene id: 593750:METFOR_RS03475
uniprot id: L0HD95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS04215
gene id: 593750:METFOR_RS04215
uniprot id: L0HAX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593750:METFOR RS00705
gene id: 593750:METFOR_RS00705
uniprot id: L0HDR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

593750:METFOR RS00855
gene id: 593750:METFOR_RS00855
uniprot id: L0HBS3
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

593750:METFOR RS13825
gene id: 593750:METFOR_RS13825
uniprot id: L0HGF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

593750:METFOR RS05140
gene id: 593750:METFOR_RS05140
uniprot id: L0HBF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

593750:METFOR RS13110
gene id: 593750:METFOR_RS13110
uniprot id: L0HI40
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

593750:METFOR RS09990
gene id: 593750:METFOR_RS09990
uniprot id: L0HIY5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

593750:METFOR RS10120
gene id: 593750:METFOR_RS10120
uniprot id: L0HJ15
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

593750:METFOR RS02490
gene id: 593750:METFOR_RS02490
uniprot id: L0H9Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS08550
gene id: 593750:METFOR_RS08550
uniprot id: L0HDH8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

593750:METFOR RS01555
gene id: 593750:METFOR_RS01555
uniprot id: L0HDJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

593750:METFOR RS12720
gene id: 593750:METFOR_RS12720
uniprot id: L0HHU6
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

593750:METFOR RS08625
gene id: 593750:METFOR_RS08625
uniprot id: L0HG74
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

593750:METFOR RS02545
gene id: 593750:METFOR_RS02545
uniprot id: L0HE31
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS10160
gene id: 593750:METFOR_RS10160
uniprot id: L0HH30
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

593750:METFOR RS07910
gene id: 593750:METFOR_RS07910
uniprot id: L0HFR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

593750:METFOR RS04235
gene id: 593750:METFOR_RS04235
uniprot id: L0HDN4
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04230
gene id: 593750:METFOR_RS04230
uniprot id: L0HD01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS10995
gene id: 593750:METFOR_RS10995
uniprot id: L0HEV8
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

593750:METFOR RS04965
gene id: 593750:METFOR_RS04965
uniprot id: L0HFF3
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

593750:METFOR RS03525
gene id: 593750:METFOR_RS03525
uniprot id: L0HDA3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS06580
gene id: 593750:METFOR_RS06580
uniprot id: L0HC99
names: Similarity
messages: Belongs to the archease family.

593750:METFOR RS11520
gene id: 593750:METFOR_RS11520
uniprot id: L0HJW5
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02425
gene id: 593750:METFOR_RS02425
uniprot id: L0HBZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS05625
gene id: 593750:METFOR_RS05625
uniprot id: L0HFV5
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

593750:METFOR RS10955
gene id: 593750:METFOR_RS10955
uniprot id: L0HIW4
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS00450
gene id: 593750:METFOR_RS00450
uniprot id: L0HB14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

593750:METFOR RS11045
gene id: 593750:METFOR_RS11045
uniprot id: L0HHM2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

593750:METFOR RS12080
gene id: 593750:METFOR_RS12080
uniprot id: L0HK70
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

593750:METFOR RS06970
gene id: 593750:METFOR_RS06970
uniprot id: L0HH89
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12325
gene id: 593750:METFOR_RS12325
uniprot id: L0HIB1
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

593750:METFOR RS12950
gene id: 593750:METFOR_RS12950
uniprot id: L0HFX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

593750:METFOR RS07825
gene id: 593750:METFOR_RS07825
uniprot id: L0HF25
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS08520
gene id: 593750:METFOR_RS08520
uniprot id: L0HFI7
names: Similarity
messages: Belongs to the HsdR family.

593750:METFOR RS03785
gene id: 593750:METFOR_RS03785
uniprot id: L0HCS6
names: Similarity
messages: Belongs to the CutA family.

593750:METFOR RS13530
gene id: 593750:METFOR_RS13530
uniprot id: L0HJ10
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS10325
gene id: 593750:METFOR_RS10325
uniprot id: L0HII4
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS05690
gene id: 593750:METFOR_RS05690
uniprot id: L0HDX4
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

593750:METFOR RS07370
gene id: 593750:METFOR_RS07370
uniprot id: L0HFF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

593750:METFOR RS06085
gene id: 593750:METFOR_RS06085
uniprot id: L0HG28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

593750:METFOR RS11795
gene id: 593750:METFOR_RS11795
uniprot id: L0HF99
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

593750:METFOR RS07590
gene id: 593750:METFOR_RS07590
uniprot id: L0HFJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

593750:METFOR RS02145
gene id: 593750:METFOR_RS02145
uniprot id: L0HBT7
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS01350
gene id: 593750:METFOR_RS01350
uniprot id: L0HE30
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS07365
gene id: 593750:METFOR_RS07365
uniprot id: L0HES1
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02650
gene id: 593750:METFOR_RS02650
uniprot id: L0HER8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

593750:METFOR RS01950
gene id: 593750:METFOR_RS01950
uniprot id: L0HCC0
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

593750:METFOR RS09950
gene id: 593750:METFOR_RS09950
uniprot id: L0HGY4
names: Similarity
messages: Belongs to the UPF0280 family.

593750:METFOR RS12940
gene id: 593750:METFOR_RS12940
uniprot id: L0HHY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

593750:METFOR RS09340
gene id: 593750:METFOR_RS09340
uniprot id: L0HIL3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS06555
gene id: 593750:METFOR_RS06555
uniprot id: L0HC94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

593750:METFOR RS14215
gene id: 593750:METFOR_RS14215
uniprot id: L0HLF6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

593750:METFOR RS05635
gene id: 593750:METFOR_RS05635
uniprot id: L0HGK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

593750:METFOR RS02020
gene id: 593750:METFOR_RS02020
uniprot id: L0HBR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

593750:METFOR RS01105
gene id: 593750:METFOR_RS01105
uniprot id: L0HDA8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

593750:METFOR RS12775
gene id: 593750:METFOR_RS12775
uniprot id: L0HFU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

593750:METFOR RS12025
gene id: 593750:METFOR_RS12025
uniprot id: L0HFE2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

593750:METFOR RS02620
gene id: 593750:METFOR_RS02620
uniprot id: L0HE48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

593750:METFOR RS07990
gene id: 593750:METFOR_RS07990
uniprot id: L0HH77
names: Similarity
messages: Belongs to the UPF0200 family.

593750:METFOR RS12690
gene id: 593750:METFOR_RS12690
uniprot id: L0HKK8
names: Similarity
messages: Belongs to the HdrB family.

593750:METFOR RS03780
gene id: 593750:METFOR_RS03780
uniprot id: L0HFF7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

593750:METFOR RS03915
gene id: 593750:METFOR_RS03915
uniprot id: L0HDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

593750:METFOR RS02665
gene id: 593750:METFOR_RS02665
uniprot id: L0HA28
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

593750:METFOR RS08355
gene id: 593750:METFOR_RS08355
uniprot id: L0HG18
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04580
gene id: 593750:METFOR_RS04580
uniprot id: L0HF77
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS00805
gene id: 593750:METFOR_RS00805
uniprot id: L0H944
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

593750:METFOR RS00045
gene id: 593750:METFOR_RS00045
uniprot id: L0H8N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

593750:METFOR RS14130
gene id: 593750:METFOR_RS14130
uniprot id: L0HGK4
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS04410
gene id: 593750:METFOR_RS04410
uniprot id: L0HFS5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

593750:METFOR RS00795
gene id: 593750:METFOR_RS00795
uniprot id: L0HB64
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03450
gene id: 593750:METFOR_RS03450
uniprot id: L0HD91
names: Similarity
messages: Belongs to the FwdC/FmdC family.

593750:METFOR RS08375
gene id: 593750:METFOR_RS08375
uniprot id: L0HG23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

593750:METFOR RS07550
gene id: 593750:METFOR_RS07550
uniprot id: L0HCV1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

593750:METFOR RS00235
gene id: 593750:METFOR_RS00235
uniprot id: L0HCV6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

593750:METFOR RS01280
gene id: 593750:METFOR_RS01280
uniprot id: L0HBE5
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01580
gene id: 593750:METFOR_RS01580
uniprot id: L0HDJ4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

593750:METFOR RS01090
gene id: 593750:METFOR_RS01090
uniprot id: L0HBB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS08215
gene id: 593750:METFOR_RS08215
uniprot id: L0HDB7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

593750:METFOR RS12305
gene id: 593750:METFOR_RS12305
uniprot id: L0HFK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

593750:METFOR RS12865
gene id: 593750:METFOR_RS12865
uniprot id: L0HHX2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

593750:METFOR RS14075
gene id: 593750:METFOR_RS14075
uniprot id: L0HJA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

593750:METFOR RS12835
gene id: 593750:METFOR_RS12835
uniprot id: L0HKP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

593750:METFOR RS05085
gene id: 593750:METFOR_RS05085
uniprot id: L0HBE7
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

593750:METFOR RS10550
gene id: 593750:METFOR_RS10550
uniprot id: L0HIP5
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

593750:METFOR RS08575
gene id: 593750:METFOR_RS08575
uniprot id: L0HG64
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

593750:METFOR RS12435
gene id: 593750:METFOR_RS12435
uniprot id: L0HFM8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

593750:METFOR RS05935
gene id: 593750:METFOR_RS05935
uniprot id: L0HBY6
names: Similarity
messages: Belongs to the peptidase M3 family.

593750:METFOR RS11090
gene id: 593750:METFOR_RS11090
uniprot id: L0HHN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

593750:METFOR RS10335
gene id: 593750:METFOR_RS10335
uniprot id: L0HGI1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS01755
gene id: 593750:METFOR_RS01755
uniprot id: L0HC89
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS10845
gene id: 593750:METFOR_RS10845
uniprot id: L0HET2
names: Similarity
messages: Belongs to the UPF0173 family.

593750:METFOR RS12365
gene id: 593750:METFOR_RS12365
uniprot id: L0HKD2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

593750:METFOR RS10835
gene id: 593750:METFOR_RS10835
uniprot id: L0HJI4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

593750:METFOR RS00905
gene id: 593750:METFOR_RS00905
uniprot id: L0H959
names: Similarity
messages: Belongs to the MoaB/Mog family.

593750:METFOR RS00240
gene id: 593750:METFOR_RS00240
uniprot id: L0HDG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

593750:METFOR RS13195
gene id: 593750:METFOR_RS13195
uniprot id: L0HI54
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

593750:METFOR RS13855
gene id: 593750:METFOR_RS13855
uniprot id: L0HKH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

593750:METFOR RS05365
gene id: 593750:METFOR_RS05365
uniprot id: L0HDN6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

593750:METFOR RS07735
gene id: 593750:METFOR_RS07735
uniprot id: L0HF04
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593750:METFOR RS02015
gene id: 593750:METFOR_RS02015
uniprot id: L0HEE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

593750:METFOR RS12810
gene id: 593750:METFOR_RS12810
uniprot id: L0HKN8
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS08365
gene id: 593750:METFOR_RS08365
uniprot id: L0HHD9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS07855
gene id: 593750:METFOR_RS07855
uniprot id: L0HFR0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

593750:METFOR RS13735
gene id: 593750:METFOR_RS13735
uniprot id: L0HL64
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

593750:METFOR RS01460
gene id: 593750:METFOR_RS01460
uniprot id: L0HBH4
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

593750:METFOR RS12750
gene id: 593750:METFOR_RS12750
uniprot id: L0HFT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

593750:METFOR RS14150
gene id: 593750:METFOR_RS14150
uniprot id: L0HJB7
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

593750:METFOR RS13235
gene id: 593750:METFOR_RS13235
uniprot id: L0HK69
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

593750:METFOR RS00940
gene id: 593750:METFOR_RS00940
uniprot id: L0HDV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS10305
gene id: 593750:METFOR_RS10305
uniprot id: L0HJ58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
messages: Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.

593750:METFOR RS02210
gene id: 593750:METFOR_RS02210
uniprot id: L0HDV8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

593750:METFOR RS13330
gene id: 593750:METFOR_RS13330
uniprot id: L0HG71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

593750:METFOR RS00260
gene id: 593750:METFOR_RS00260
uniprot id: L0HCW2
names: Similarity
messages: Belongs to the ZPR1 family.

593750:METFOR RS04890
gene id: 593750:METFOR_RS04890
uniprot id: L0HFD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

593750:METFOR RS08285
gene id: 593750:METFOR_RS08285
uniprot id: U3GM72
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

593750:METFOR RS01745
gene id: 593750:METFOR_RS01745
uniprot id: L0HEA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

593750:METFOR RS05585
gene id: 593750:METFOR_RS05585
uniprot id: L0HGJ2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS00720
gene id: 593750:METFOR_RS00720
uniprot id: L0H931
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04655
gene id: 593750:METFOR_RS04655
uniprot id: L0HFW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

593750:METFOR RS00580
gene id: 593750:METFOR_RS00580
uniprot id: L0HB34
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

593750:METFOR RS08135
gene id: 593750:METFOR_RS08135
uniprot id: L0HDA5
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

593750:METFOR RS12935
gene id: 593750:METFOR_RS12935
uniprot id: L0HKR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

593750:METFOR RS04670
gene id: 593750:METFOR_RS04670
uniprot id: L0HB65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

593750:METFOR RS09815
gene id: 593750:METFOR_RS09815
uniprot id: L0HE55
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

593750:METFOR RS12755
gene id: 593750:METFOR_RS12755
uniprot id: L0HJX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

593750:METFOR RS13270
gene id: 593750:METFOR_RS13270
uniprot id: L0HI66
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS10350
gene id: 593750:METFOR_RS10350
uniprot id: L0HIJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

593750:METFOR RS06995
gene id: 593750:METFOR_RS06995
uniprot id: L0HH95
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

593750:METFOR RS11770
gene id: 593750:METFOR_RS11770
uniprot id: L0HF95
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

593750:METFOR RS11310
gene id: 593750:METFOR_RS11310
uniprot id: L0HHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

593750:METFOR RS02435
gene id: 593750:METFOR_RS02435
uniprot id: L0H9Y1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

593750:METFOR RS03540
gene id: 593750:METFOR_RS03540
uniprot id: L0HFA8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

593750:METFOR RS10750
gene id: 593750:METFOR_RS10750
uniprot id: L0HER3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

593750:METFOR RS10885
gene id: 593750:METFOR_RS10885
uniprot id: L0HGV6
names: Similarity
messages: Belongs to the UPF0305 family.

593750:METFOR RS03000
gene id: 593750:METFOR_RS03000
uniprot id: L0HD16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

593750:METFOR RS00455
gene id: 593750:METFOR_RS00455
uniprot id: L0HBL3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS11280
gene id: 593750:METFOR_RS11280
uniprot id: L0HH24
names: Similarity
messages: Belongs to the UPF0146 family.

593750:METFOR RS01575
gene id: 593750:METFOR_RS01575
uniprot id: L0H9H3
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

593750:METFOR RS10140
gene id: 593750:METFOR_RS10140
uniprot id: L0HEC0
names: Similarity
messages: Belongs to the UPF0111 family.

593750:METFOR RS13475
gene id: 593750:METFOR_RS13475
uniprot id: L0HKA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

593750:METFOR RS00870
gene id: 593750:METFOR_RS00870
uniprot id: L0HDU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

593750:METFOR RS09935
gene id: 593750:METFOR_RS09935
uniprot id: L0HI98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

593750:METFOR RS01065
gene id: 593750:METFOR_RS01065
uniprot id: L0HBB2
names: Similarity
messages: Belongs to the UPF0288 family.

593750:METFOR RS14125
gene id: 593750:METFOR_RS14125
uniprot id: L0HJB3
names: Similarity
messages: Belongs to the malic enzymes family.

593750:METFOR RS13815
gene id: 593750:METFOR_RS13815
uniprot id: L0HIG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

593750:METFOR RS04540
gene id: 593750:METFOR_RS04540
uniprot id: L0HD58
names: Similarity
messages: Belongs to the UPF0252 family.

593750:METFOR RS06140
gene id: 593750:METFOR_RS06140
uniprot id: L0HGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS04780
gene id: 593750:METFOR_RS04780
uniprot id: L0HFB6
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

593750:METFOR RS07525
gene id: 593750:METFOR_RS07525
uniprot id: L0HCU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS08445
gene id: 593750:METFOR_RS08445
uniprot id: L0HFH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

593750:METFOR RS01070
gene id: 593750:METFOR_RS01070
uniprot id: L0HBW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS03825
gene id: 593750:METFOR_RS03825
uniprot id: L0HET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS12490
gene id: 593750:METFOR_RS12490
uniprot id: L0HJR7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

593750:METFOR RS12820
gene id: 593750:METFOR_RS12820
uniprot id: L0HIL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

593750:METFOR RS04425
gene id: 593750:METFOR_RS04425
uniprot id: L0HB12
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13880
gene id: 593750:METFOR_RS13880
uniprot id: L0HKH7
names: Similarity
messages: Belongs to the phosphoribulokinase family.

593750:METFOR RS02310
gene id: 593750:METFOR_RS02310
uniprot id: L0HDX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

593750:METFOR RS02510
gene id: 593750:METFOR_RS02510
uniprot id: L0HCP6
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS06700
gene id: 593750:METFOR_RS06700
uniprot id: L0HCC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

593750:METFOR RS00040
gene id: 593750:METFOR_RS00040
uniprot id: L0HBB5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

593750:METFOR RS13865
gene id: 593750:METFOR_RS13865
uniprot id: L0HIH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

593750:METFOR RS10150
gene id: 593750:METFOR_RS10150
uniprot id: L0HJ22
names: Similarity
messages: Belongs to the UPF0111 family.

593750:METFOR RS02415
gene id: 593750:METFOR_RS02415
uniprot id: L0HE04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

593750:METFOR RS12885
gene id: 593750:METFOR_RS12885
uniprot id: L0HKQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

593750:METFOR RS10590
gene id: 593750:METFOR_RS10590
uniprot id: L0HHE1
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

593750:METFOR RS08290
gene id: 593750:METFOR_RS08290
uniprot id: L0HDC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

593750:METFOR RS05120
gene id: 593750:METFOR_RS05120
uniprot id: L0HFI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593750:METFOR RS12555
gene id: 593750:METFOR_RS12555
uniprot id: L0HIF8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

593750:METFOR RS09025
gene id: 593750:METFOR_RS09025
uniprot id: L0HGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

593750:METFOR RS11140
gene id: 593750:METFOR_RS11140
uniprot id: L0HJ04
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

593750:METFOR RS09285
gene id: 593750:METFOR_RS09285
uniprot id: L0HGJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

593750:METFOR RS01975
gene id: 593750:METFOR_RS01975
uniprot id: L0HCC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

593750:METFOR RS13550
gene id: 593750:METFOR_RS13550
uniprot id: L0HIB6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

593750:METFOR RS10580
gene id: 593750:METFOR_RS10580
uniprot id: L0HJE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12295
gene id: 593750:METFOR_RS12295
uniprot id: L0HHK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

593750:METFOR RS09640
gene id: 593750:METFOR_RS09640
uniprot id: L0HIR6
names: Similarity
messages: Belongs to the serpin family.

593750:METFOR RS05790
gene id: 593750:METFOR_RS05790
uniprot id: L0HFY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS10500
gene id: 593750:METFOR_RS10500
uniprot id: L0HEK2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

593750:METFOR RS12260
gene id: 593750:METFOR_RS12260
uniprot id: L0HJL3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02300
gene id: 593750:METFOR_RS02300
uniprot id: L0HCJ8
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

593750:METFOR RS02965
gene id: 593750:METFOR_RS02965
uniprot id: L0HCB0
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

593750:METFOR RS04700
gene id: 593750:METFOR_RS04700
uniprot id: L0HFA1
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02485
gene id: 593750:METFOR_RS02485
uniprot id: L0HCP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

593750:METFOR RS07420
gene id: 593750:METFOR_RS07420
uniprot id: L0HFG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS09620
gene id: 593750:METFOR_RS09620
uniprot id: L0HG27
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

593750:METFOR RS08695
gene id: 593750:METFOR_RS08695
uniprot id: L0HI96
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

593750:METFOR RS13870
gene id: 593750:METFOR_RS13870
uniprot id: L0HJ71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

593750:METFOR RS06695
gene id: 593750:METFOR_RS06695
uniprot id: L0HF21
names: Similarity
messages: Belongs to the MCM family.

593750:METFOR RS04575
gene id: 593750:METFOR_RS04575
uniprot id: L0HB41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593750:METFOR RS01590
gene id: 593750:METFOR_RS01590
uniprot id: L0HBJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

593750:METFOR RS08720
gene id: 593750:METFOR_RS08720
uniprot id: L0HIA1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

593750:METFOR RS02465
gene id: 593750:METFOR_RS02465
uniprot id: L0H9Y6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

593750:METFOR RS07375
gene id: 593750:METFOR_RS07375
uniprot id: L0HCR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Transport of potassium into the cell.

593750:METFOR RS06310
gene id: 593750:METFOR_RS06310
uniprot id: L0HGW6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

593750:METFOR RS04530
gene id: 593750:METFOR_RS04530
uniprot id: L0HF67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

593750:METFOR RS12675
gene id: 593750:METFOR_RS12675
uniprot id: L0HHT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

593750:METFOR RS06665
gene id: 593750:METFOR_RS06665
uniprot id: L0HEE1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS04225
gene id: 593750:METFOR_RS04225
uniprot id: L0HFP5
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

593750:METFOR RS12360
gene id: 593750:METFOR_RS12360
uniprot id: L0HJN8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

593750:METFOR RS12805
gene id: 593750:METFOR_RS12805
uniprot id: L0HJY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS09655
gene id: 593750:METFOR_RS09655
uniprot id: L0HE28
names: Similarity
messages: Belongs to the FTR family.

593750:METFOR RS14035
gene id: 593750:METFOR_RS14035
uniprot id: L0HLC4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

593750:METFOR RS03770
gene id: 593750:METFOR_RS03770
uniprot id: L0HAP6
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

593750:METFOR RS07195
gene id: 593750:METFOR_RS07195
uniprot id: L0HGN7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

593750:METFOR RS02655
gene id: 593750:METFOR_RS02655
uniprot id: L0HC46
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS03550
gene id: 593750:METFOR_RS03550
uniprot id: L0HDA6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

593750:METFOR RS03440
gene id: 593750:METFOR_RS03440
uniprot id: L0HF89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

593750:METFOR RS08140
gene id: 593750:METFOR_RS08140
uniprot id: L0HHA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

593750:METFOR RS09820
gene id: 593750:METFOR_RS09820
uniprot id: L0HI71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS04135
gene id: 593750:METFOR_RS04135
uniprot id: L0HEZ0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593750:METFOR RS00415
gene id: 593750:METFOR_RS00415
uniprot id: L0HCZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

593750:METFOR RS11735
gene id: 593750:METFOR_RS11735
uniprot id: L0HH99
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

593750:METFOR RS03015
gene id: 593750:METFOR_RS03015
uniprot id: L0HF13
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

593750:METFOR RS03530
gene id: 593750:METFOR_RS03530
uniprot id: L0HAK5
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

593750:METFOR RS01585
gene id: 593750:METFOR_RS01585
uniprot id: L0HE74
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593750:METFOR RS10505
gene id: 593750:METFOR_RS10505
uniprot id: L0HIN3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

593750:METFOR RS12020
gene id: 593750:METFOR_RS12020
uniprot id: L0HI48
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

593750:METFOR RS01255
gene id: 593750:METFOR_RS01255
uniprot id: L0HBE0
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS11740
gene id: 593750:METFOR_RS11740
uniprot id: L0HHZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS10800
gene id: 593750:METFOR_RS10800
uniprot id: L0HES2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

593750:METFOR RS13290
gene id: 593750:METFOR_RS13290
uniprot id: L0HKX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS10295
gene id: 593750:METFOR_RS10295
uniprot id: L0HEE7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12355
gene id: 593750:METFOR_RS12355
uniprot id: L0HFL3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

593750:METFOR RS04445
gene id: 593750:METFOR_RS04445
uniprot id: L0HDS5
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

593750:METFOR RS08270
gene id: 593750:METFOR_RS08270
uniprot id: L0HHC5
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

593750:METFOR RS04930
gene id: 593750:METFOR_RS04930
uniprot id: L0HE26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS07965
gene id: 593750:METFOR_RS07965
uniprot id: L0HH58
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS10445
gene id: 593750:METFOR_RS10445
uniprot id: L0HH91
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

593750:METFOR RS05525
gene id: 593750:METFOR_RS05525
uniprot id: L0HBQ1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

593750:METFOR RS04925
gene id: 593750:METFOR_RS04925
uniprot id: L0HDE3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01225
gene id: 593750:METFOR_RS01225
uniprot id: L0HBZ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS01125
gene id: 593750:METFOR_RS01125
uniprot id: L0H995
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS03850
gene id: 593750:METFOR_RS03850
uniprot id: L0HET8
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

593750:METFOR RS12430
gene id: 593750:METFOR_RS12430
uniprot id: L0HID3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

593750:METFOR RS03630
gene id: 593750:METFOR_RS03630
uniprot id: L0HAM2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

593750:METFOR RS02480
gene id: 593750:METFOR_RS02480
uniprot id: L0HC06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS10670
gene id: 593750:METFOR_RS10670
uniprot id: L0HEQ2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS01295
gene id: 593750:METFOR_RS01295
uniprot id: L0HDE1
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

593750:METFOR RS05765
gene id: 593750:METFOR_RS05765
uniprot id: L0HFX5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

593750:METFOR RS06335
gene id: 593750:METFOR_RS06335
uniprot id: L0HE86
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

593750:METFOR RS00205
gene id: 593750:METFOR_RS00205
uniprot id: L0HCV0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS05545
gene id: 593750:METFOR_RS05545
uniprot id: L0HEH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

593750:METFOR RS03355
gene id: 593750:METFOR_RS03355
uniprot id: L0HD73
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS09685
gene id: 593750:METFOR_RS09685
uniprot id: L0HI39
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS00465
gene id: 593750:METFOR_RS00465
uniprot id: L0HD03
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS04195
gene id: 593750:METFOR_RS04195
uniprot id: L0HAX0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS07980
gene id: 593750:METFOR_RS07980
uniprot id: L0HFU6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12255
gene id: 593750:METFOR_RS12255
uniprot id: L0HFI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS12860
gene id: 593750:METFOR_RS12860
uniprot id: L0HKP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS04315
gene id: 593750:METFOR_RS04315
uniprot id: L0HD12
names: Similarity
messages: Belongs to the UPF0254 family.

593750:METFOR RS03105
gene id: 593750:METFOR_RS03105
uniprot id: L0HAD2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

593750:METFOR RS14010
gene id: 593750:METFOR_RS14010
uniprot id: L0HLC0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS12725
gene id: 593750:METFOR_RS12725
uniprot id: L0HIJ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

593750:METFOR RS05135
gene id: 593750:METFOR_RS05135
uniprot id: L0HE71
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

593750:METFOR RS06290
gene id: 593750:METFOR_RS06290
uniprot id: L0HE78
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

593750:METFOR RS13200
gene id: 593750:METFOR_RS13200
uniprot id: L0HIV4
names: Similarity
messages: Belongs to the AAA ATPase family.

593750:METFOR RS12890
gene id: 593750:METFOR_RS12890
uniprot id: L0HHX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

593750:METFOR RS04400
gene id: 593750:METFOR_RS04400
uniprot id: L0HB07
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS05580
gene id: 593750:METFOR_RS05580
uniprot id: L0HFU8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS06455
gene id: 593750:METFOR_RS06455
uniprot id: L0HEA8
names: Similarity
messages: Belongs to the polysaccharide synthase family.

593750:METFOR RS10440
gene id: 593750:METFOR_RS10440
uniprot id: L0HGK2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

593750:METFOR RS14105
gene id: 593750:METFOR_RS14105
uniprot id: L0HGJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

593750:METFOR RS01310
gene id: 593750:METFOR_RS01310
uniprot id: L0HC08
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593750:METFOR RS02325
gene id: 593750:METFOR_RS02325
uniprot id: L0HCK5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS05680
gene id: 593750:METFOR_RS05680
uniprot id: L0HFW4
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

593750:METFOR RS08340
gene id: 593750:METFOR_RS08340
uniprot id: L0HHD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

593750:METFOR RS04190
gene id: 593750:METFOR_RS04190
uniprot id: L0HDM4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS05275
gene id: 593750:METFOR_RS05275
uniprot id: L0HG99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS05795
gene id: 593750:METFOR_RS05795
uniprot id: L0HGM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593750:METFOR RS12250
gene id: 593750:METFOR_RS12250
uniprot id: L0HI97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

593750:METFOR RS02445
gene id: 593750:METFOR_RS02445
uniprot id: L0HEM3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

593750:METFOR RS07850
gene id: 593750:METFOR_RS07850
uniprot id: L0HF30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS11990
gene id: 593750:METFOR_RS11990
uniprot id: L0HHE0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

593750:METFOR RS04980
gene id: 593750:METFOR_RS04980
uniprot id: L0HE37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS10915
gene id: 593750:METFOR_RS10915
uniprot id: L0HGW0
names: Similarity
messages: Belongs to the UPF0047 family.

593750:METFOR RS12230
gene id: 593750:METFOR_RS12230
uniprot id: L0HI90
names: Similarity
messages: Belongs to the UPF0284 family.

593750:METFOR RS01670
gene id: 593750:METFOR_RS01670
uniprot id: L0HC75
names: Similarity
messages: Belongs to the archaeal-type GPI family.

593750:METFOR RS04240
gene id: 593750:METFOR_RS04240
uniprot id: L0HAX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

593750:METFOR RS07280
gene id: 593750:METFOR_RS07280
uniprot id: L0HFD5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

593750:METFOR RS12880
gene id: 593750:METFOR_RS12880
uniprot id: L0HK05
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS09725
gene id: 593750:METFOR_RS09725
uniprot id: L0HGT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

593750:METFOR RS03020
gene id: 593750:METFOR_RS03020
uniprot id: L0HCC8
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS05520
gene id: 593750:METFOR_RS05520
uniprot id: L0HEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

593750:METFOR RS08460
gene id: 593750:METFOR_RS08460
uniprot id: L0HHF5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

593750:METFOR RS06230
gene id: 593750:METFOR_RS06230
uniprot id: L0HG54
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02110
gene id: 593750:METFOR_RS02110
uniprot id: L0HDT6
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

593750:METFOR RS00105
gene id: 593750:METFOR_RS00105
uniprot id: U3GLF1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12895
gene id: 593750:METFOR_RS12895
uniprot id: L0HIN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS03955
gene id: 593750:METFOR_RS03955
uniprot id: L0HFJ1
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12830
gene id: 593750:METFOR_RS12830
uniprot id: L0HJZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

593750:METFOR RS13875
gene id: 593750:METFOR_RS13875
uniprot id: L0HGG2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS01550
gene id: 593750:METFOR_RS01550
uniprot id: L0H9G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

593750:METFOR RS07945
gene id: 593750:METFOR_RS07945
uniprot id: L0HHU5
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS08395
gene id: 593750:METFOR_RS08395
uniprot id: L0HFG5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

593750:METFOR RS05515
gene id: 593750:METFOR_RS05515
uniprot id: L0HDT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

593750:METFOR RS09070
gene id: 593750:METFOR_RS09070
uniprot id: L0HFS8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

593750:METFOR RS03620
gene id: 593750:METFOR_RS03620
uniprot id: L0HCP2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03935
gene id: 593750:METFOR_RS03935
uniprot id: L0HCV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

593750:METFOR RS05400
gene id: 593750:METFOR_RS05400
uniprot id: L0HBK5
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03755
gene id: 593750:METFOR_RS03755
uniprot id: L0HFF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

593750:METFOR RS14260
gene id: 593750:METFOR_RS14260
uniprot id: L0HKQ1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

593750:METFOR RS00575
gene id: 593750:METFOR_RS00575
uniprot id: L0HDQ2
names: Similarity
messages: Belongs to the DMRL synthase family.

593750:METFOR RS01080
gene id: 593750:METFOR_RS01080
uniprot id: L0HDA4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

593750:METFOR RS09925
gene id: 593750:METFOR_RS09925
uniprot id: L0HGX9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

593750:METFOR RS01810
gene id: 593750:METFOR_RS01810
uniprot id: L0HC97
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01780
gene id: 593750:METFOR_RS01780
uniprot id: L0HC93
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

593750:METFOR RS03970
gene id: 593750:METFOR_RS03970
uniprot id: L0HAT3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS13275
gene id: 593750:METFOR_RS13275
uniprot id: L0HIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

593750:METFOR RS04995
gene id: 593750:METFOR_RS04995
uniprot id: L0HG31
names: Similarity
messages: Belongs to the NOP10 family.

593750:METFOR RS02225
gene id: 593750:METFOR_RS02225
uniprot id: L0HCI1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS08090
gene id: 593750:METFOR_RS08090
uniprot id: L0HHA0
names: Similarity
messages: Belongs to the HypD family.

593750:METFOR RS05130
gene id: 593750:METFOR_RS05130
uniprot id: L0HDI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

593750:METFOR RS08360
gene id: 593750:METFOR_RS08360
uniprot id: L0HDE2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS05675
gene id: 593750:METFOR_RS05675
uniprot id: L0HBT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

593750:METFOR RS06600
gene id: 593750:METFOR_RS06600
uniprot id: L0HF05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

593750:METFOR RS10830
gene id: 593750:METFOR_RS10830
uniprot id: L0HIU2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02230
gene id: 593750:METFOR_RS02230
uniprot id: L0H9U3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13010
gene id: 593750:METFOR_RS13010
uniprot id: L0HK40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

593750:METFOR RS03840
gene id: 593750:METFOR_RS03840
uniprot id: L0HDG3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

593750:METFOR RS07145
gene id: 593750:METFOR_RS07145
uniprot id: L0HGM8
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

593750:METFOR RS13225
gene id: 593750:METFOR_RS13225
uniprot id: L0HIV9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS10075
gene id: 593750:METFOR_RS10075
uniprot id: L0HH14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

593750:METFOR RS09370
gene id: 593750:METFOR_RS09370
uniprot id: L0HGK5
names: Similarity
messages: Belongs to the HerA family.

593750:METFOR RS10470
gene id: 593750:METFOR_RS10470
uniprot id: L0HH96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

593750:METFOR RS01395
gene id: 593750:METFOR_RS01395
uniprot id: L0H9D9
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

593750:METFOR RS13080
gene id: 593750:METFOR_RS13080
uniprot id: L0HKU9
names: Similarity
messages: Belongs to the DtxR/MntR family.

593750:METFOR RS05950
gene id: 593750:METFOR_RS05950
uniprot id: L0HGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

593750:METFOR RS13095
gene id: 593750:METFOR_RS13095
uniprot id: L0HG30
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04665
gene id: 593750:METFOR_RS04665
uniprot id: L0HDX2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03040
gene id: 593750:METFOR_RS03040
uniprot id: L0HF16
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

593750:METFOR RS10725
gene id: 593750:METFOR_RS10725
uniprot id: L0HEQ9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS05435
gene id: 593750:METFOR_RS05435
uniprot id: L0HGD5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

593750:METFOR RS05780
gene id: 593750:METFOR_RS05780
uniprot id: L0HEL1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

593750:METFOR RS10380
gene id: 593750:METFOR_RS10380
uniprot id: L0HJ77
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS13570
gene id: 593750:METFOR_RS13570
uniprot id: L0HL37
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

593750:METFOR RS05065
gene id: 593750:METFOR_RS05065
uniprot id: L0HG48
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS00570
gene id: 593750:METFOR_RS00570
uniprot id: L0HD20
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

593750:METFOR RS08670
gene id: 593750:METFOR_RS08670
uniprot id: L0HI92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

593750:METFOR RS01380
gene id: 593750:METFOR_RS01380
uniprot id: L0HBG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

593750:METFOR RS10735
gene id: 593750:METFOR_RS10735
uniprot id: L0HJG6
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS10175
gene id: 593750:METFOR_RS10175
uniprot id: L0HJ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

593750:METFOR RS03590
gene id: 593750:METFOR_RS03590
uniprot id: L0HFB7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS05770
gene id: 593750:METFOR_RS05770
uniprot id: L0HGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593750:METFOR RS00910
gene id: 593750:METFOR_RS00910
uniprot id: L0HD71
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

593750:METFOR RS13835
gene id: 593750:METFOR_RS13835
uniprot id: L0HL84
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12855
gene id: 593750:METFOR_RS12855
uniprot id: L0HK01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

593750:METFOR RS12970
gene id: 593750:METFOR_RS12970
uniprot id: L0HIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

593750:METFOR RS10515
gene id: 593750:METFOR_RS10515
uniprot id: L0HGN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

593750:METFOR RS10920
gene id: 593750:METFOR_RS10920
uniprot id: L0HHJ9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

593750:METFOR RS10035
gene id: 593750:METFOR_RS10035
uniprot id: L0HIC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

593750:METFOR RS11385
gene id: 593750:METFOR_RS11385
uniprot id: L0HHT4
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS10155
gene id: 593750:METFOR_RS10155
uniprot id: L0HGE4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

593750:METFOR RS14225
gene id: 593750:METFOR_RS14225
uniprot id: L0HJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

593750:METFOR RS11055
gene id: 593750:METFOR_RS11055
uniprot id: L0HIY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS08905
gene id: 593750:METFOR_RS08905
uniprot id: L0HDN5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

593750:METFOR RS04440
gene id: 593750:METFOR_RS04440
uniprot id: L0HD38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS14990
gene id: 593750:METFOR_RS14990
uniprot id: L0HFZ2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

593750:METFOR RS00245
gene id: 593750:METFOR_RS00245
uniprot id: L0HAV4
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

593750:METFOR RS12650
gene id: 593750:METFOR_RS12650
uniprot id: L0HHS8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

593750:METFOR RS05890
gene id: 593750:METFOR_RS05890
uniprot id: L0HEM7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

593750:METFOR RS01325
gene id: 593750:METFOR_RS01325
uniprot id: L0HE27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

593750:METFOR RS13160
gene id: 593750:METFOR_RS13160
uniprot id: L0HI49
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

593750:METFOR RS07830
gene id: 593750:METFOR_RS07830
uniprot id: L0HFQ4
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

593750:METFOR RS02450
gene id: 593750:METFOR_RS02450
uniprot id: L0HC01
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593750:METFOR RS12945
gene id: 593750:METFOR_RS12945
uniprot id: L0HIP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS05445
gene id: 593750:METFOR_RS05445
uniprot id: L0HED4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

593750:METFOR RS02715
gene id: 593750:METFOR_RS02715
uniprot id: L0HES9
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS08630
gene id: 593750:METFOR_RS08630
uniprot id: L0HDI9
names: Similarity
messages: Belongs to the HupF/HypC family.

593750:METFOR RS02470
gene id: 593750:METFOR_RS02470
uniprot id: L0HE15
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

593750:METFOR RS11180
gene id: 593750:METFOR_RS11180
uniprot id: L0HHP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

593750:METFOR RS12930
gene id: 593750:METFOR_RS12930
uniprot id: L0HK16
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

593750:METFOR RS10395
gene id: 593750:METFOR_RS10395
uniprot id: L0HEG3
names: Similarity
messages: Belongs to the UPF0235 family.

593750:METFOR RS05785
gene id: 593750:METFOR_RS05785
uniprot id: L0HBV8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

593750:METFOR RS12240
gene id: 593750:METFOR_RS12240
uniprot id: L0HJK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

593750:METFOR RS13955
gene id: 593750:METFOR_RS13955
uniprot id: L0HKJ3
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

593750:METFOR RS11370
gene id: 593750:METFOR_RS11370
uniprot id: L0HJ46
names: Similarity
messages: Belongs to the class-I fumarase family.

593750:METFOR RS01970
gene id: 593750:METFOR_RS01970
uniprot id: L0HBP9
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

593750:METFOR RS10575
gene id: 593750:METFOR_RS10575
uniprot id: L0HIQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

593750:METFOR RS10525
gene id: 593750:METFOR_RS10525
uniprot id: L0HEM1
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

593750:METFOR RS07610
gene id: 593750:METFOR_RS07610
uniprot id: L0HEX7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12175
gene id: 593750:METFOR_RS12175
uniprot id: L0HHH4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

593750:METFOR RS09570
gene id: 593750:METFOR_RS09570
uniprot id: L0HIQ3
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

593750:METFOR RS05470
gene id: 593750:METFOR_RS05470
uniprot id: L0HED8
names: Subcellular Location Annotation
messages: Cell membrane

593750:METFOR RS10145
gene id: 593750:METFOR_RS10145
uniprot id: L0HIE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

593750:METFOR RS13820
gene id: 593750:METFOR_RS13820
uniprot id: L0HJ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS08920
gene id: 593750:METFOR_RS08920
uniprot id: L0HFQ3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS05425
gene id: 593750:METFOR_RS05425
uniprot id: L0HBL0
names: Similarity
messages: Belongs to the PDCD5 family.

593750:METFOR RS03865
gene id: 593750:METFOR_RS03865
uniprot id: L0HDG5
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

593750:METFOR RS12425
gene id: 593750:METFOR_RS12425
uniprot id: L0HHM9
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

593750:METFOR RS08505
gene id: 593750:METFOR_RS08505
uniprot id: L0HDG9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS13105
gene id: 593750:METFOR_RS13105
uniprot id: L0HKV4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

593750:METFOR RS02430
gene id: 593750:METFOR_RS02430
uniprot id: L0HCN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593750:METFOR RS05420
gene id: 593750:METFOR_RS05420
uniprot id: L0HEC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS14160
gene id: 593750:METFOR_RS14160
uniprot id: L0HKN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

593750:METFOR RS10355
gene id: 593750:METFOR_RS10355
uniprot id: L0HJ72
names: Similarity
messages: Belongs to the GARS family.

593750:METFOR RS11315
gene id: 593750:METFOR_RS11315
uniprot id: L0HF10
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

593750:METFOR RS01570
gene id: 593750:METFOR_RS01570
uniprot id: L0HC57
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593750:METFOR RS06385
gene id: 593750:METFOR_RS06385
uniprot id: L0HEX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

593750:METFOR RS12640
gene id: 593750:METFOR_RS12640
uniprot id: L0HJV2
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

593750:METFOR RS00955
gene id: 593750:METFOR_RS00955
uniprot id: L0H965
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

593750:METFOR RS12225
gene id: 593750:METFOR_RS12225
uniprot id: L0HHI5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

593750:METFOR RS01565
gene id: 593750:METFOR_RS01565
uniprot id: L0HBI9
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593750:METFOR RS05555
gene id: 593750:METFOR_RS05555
uniprot id: L0HFU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

593750:METFOR RS13480
gene id: 593750:METFOR_RS13480
uniprot id: L0HL18
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS13055
gene id: 593750:METFOR_RS13055
uniprot id: L0HI23
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

593750:METFOR RS12845
gene id: 593750:METFOR_RS12845
uniprot id: L0HIM3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS08960
gene id: 593750:METFOR_RS08960
uniprot id: L0HHQ0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

593750:METFOR RS03100
gene id: 593750:METFOR_RS03100
uniprot id: L0HD35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS11305
gene id: 593750:METFOR_RS11305
uniprot id: L0HH29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

593750:METFOR RS08195
gene id: 593750:METFOR_RS08195
uniprot id: L0HHB6
names: Similarity
messages: Belongs to the malic enzymes family.

593750:METFOR RS01455
gene id: 593750:METFOR_RS01455
uniprot id: L0HE50
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

593750:METFOR RS03140
gene id: 593750:METFOR_RS03140
uniprot id: L0HEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593750:METFOR RS10945
gene id: 593750:METFOR_RS10945
uniprot id: L0HHK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

593750:METFOR RS00585
gene id: 593750:METFOR_RS00585
uniprot id: L0HBN2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

593750:METFOR RS10940
gene id: 593750:METFOR_RS10940
uniprot id: L0HGW5
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS10315
gene id: 593750:METFOR_RS10315
uniprot id: L0HH65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

593750:METFOR RS13215
gene id: 593750:METFOR_RS13215
uniprot id: L0HKW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

593750:METFOR RS03950
gene id: 593750:METFOR_RS03950
uniprot id: L0HEV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS13025
gene id: 593750:METFOR_RS13025
uniprot id: L0HI20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

593750:METFOR RS06650
gene id: 593750:METFOR_RS06650
uniprot id: L0HCB2
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

593750:METFOR RS00760
gene id: 593750:METFOR_RS00760
uniprot id: L0HDS6
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS02720
gene id: 593750:METFOR_RS02720
uniprot id: L0HC58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS10170
gene id: 593750:METFOR_RS10170
uniprot id: L0HIF4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS03925
gene id: 593750:METFOR_RS03925
uniprot id: L0HEV2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13990
gene id: 593750:METFOR_RS13990
uniprot id: L0HIJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

593750:METFOR RS06485
gene id: 593750:METFOR_RS06485
uniprot id: L0HEY9
names: Similarity
messages: Belongs to the HisA/HisF family.

593750:METFOR RS03400
gene id: 593750:METFOR_RS03400
uniprot id: L0HCK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS05575
gene id: 593750:METFOR_RS05575
uniprot id: L0HBR2
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS06340
gene id: 593750:METFOR_RS06340
uniprot id: L0HEW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

593750:METFOR RS10255
gene id: 593750:METFOR_RS10255
uniprot id: L0HJ47
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

593750:METFOR RS10055
gene id: 593750:METFOR_RS10055
uniprot id: L0HEA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

593750:METFOR RS01475
gene id: 593750:METFOR_RS01475
uniprot id: L0HDH6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

593750:METFOR RS10320
gene id: 593750:METFOR_RS10320
uniprot id: L0HEF1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

593750:METFOR RS12155
gene id: 593750:METFOR_RS12155
uniprot id: L0HHG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

593750:METFOR RS10285
gene id: 593750:METFOR_RS10285
uniprot id: L0HGG9
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01960
gene id: 593750:METFOR_RS01960
uniprot id: L0HDQ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

593750:METFOR RS04755
gene id: 593750:METFOR_RS04755
uniprot id: L0HFY8
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03210
gene id: 593750:METFOR_RS03210
uniprot id: L0HAF0
names: Similarity
messages: Belongs to the FwdC/FmdC family.

593750:METFOR RS00915
gene id: 593750:METFOR_RS00915
uniprot id: L0HDV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

593750:METFOR RS03895
gene id: 593750:METFOR_RS03895
uniprot id: L0HAR8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS05045
gene id: 593750:METFOR_RS05045
uniprot id: L0HDH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

593750:METFOR RS05740
gene id: 593750:METFOR_RS05740
uniprot id: L0HFX1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS13960
gene id: 593750:METFOR_RS13960
uniprot id: L0HLB0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS07245
gene id: 593750:METFOR_RS07245
uniprot id: L0HGP5
names: Similarity
messages: Belongs to the Nth/MutY family.

593750:METFOR RS12705
gene id: 593750:METFOR_RS12705
uniprot id: L0HFT2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

593750:METFOR RS01400
gene id: 593750:METFOR_RS01400
uniprot id: L0HDG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

593750:METFOR RS10195
gene id: 593750:METFOR_RS10195
uniprot id: L0HIF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

593750:METFOR RS08450
gene id: 593750:METFOR_RS08450
uniprot id: L0HG40
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

593750:METFOR RS07540
gene id: 593750:METFOR_RS07540
uniprot id: L0HEV9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

593750:METFOR RS08095
gene id: 593750:METFOR_RS08095
uniprot id: L0HHZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

593750:METFOR RS08280
gene id: 593750:METFOR_RS08280
uniprot id: L0HFE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

593750:METFOR RS10475
gene id: 593750:METFOR_RS10475
uniprot id: L0HEI0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

593750:METFOR RS13705
gene id: 593750:METFOR_RS13705
uniprot id: L0HKE4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

593750:METFOR RS03610
gene id: 593750:METFOR_RS03610
uniprot id: L0HEN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

593750:METFOR RS00350
gene id: 593750:METFOR_RS00350
uniprot id: L0HAZ5
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

593750:METFOR RS12905
gene id: 593750:METFOR_RS12905
uniprot id: L0HK10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS11790
gene id: 593750:METFOR_RS11790
uniprot id: L0HI05
names: Similarity
messages: Belongs to the UPF0212 family.

593750:METFOR RS07285
gene id: 593750:METFOR_RS07285
uniprot id: L0HCQ0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

593750:METFOR RS01115
gene id: 593750:METFOR_RS01115
uniprot id: L0HBC0
names: Similarity
messages: Belongs to the LarC family.

593750:METFOR RS08130
gene id: 593750:METFOR_RS08130
uniprot id: L0HFY5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

593750:METFOR RS09875
gene id: 593750:METFOR_RS09875
uniprot id: L0HGW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

593750:METFOR RS08180
gene id: 593750:METFOR_RS08180
uniprot id: L0HFC4
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13000
gene id: 593750:METFOR_RS13000
uniprot id: L0HIS5
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

593750:METFOR RS12280
gene id: 593750:METFOR_RS12280
uniprot id: L0HFJ6
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

593750:METFOR RS05725
gene id: 593750:METFOR_RS05725
uniprot id: L0HDX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

593750:METFOR RS13355
gene id: 593750:METFOR_RS13355
uniprot id: L0HG76
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

593750:METFOR RS04210
gene id: 593750:METFOR_RS04210
uniprot id: L0HDM9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS01650
gene id: 593750:METFOR_RS01650
uniprot id: L0H9I6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS12335
gene id: 593750:METFOR_RS12335
uniprot id: L0HJN1
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13725
gene id: 593750:METFOR_RS13725
uniprot id: L0HGD9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

593750:METFOR RS10365
gene id: 593750:METFOR_RS10365
uniprot id: L0HH76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

593750:METFOR RS12875
gene id: 593750:METFOR_RS12875
uniprot id: L0HFW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS12735
gene id: 593750:METFOR_RS12735
uniprot id: L0HKM0
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

593750:METFOR RS14025
gene id: 593750:METFOR_RS14025
uniprot id: L0HGI7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

593750:METFOR RS13950
gene id: 593750:METFOR_RS13950
uniprot id: L0HGH4
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

593750:METFOR RS01190
gene id: 593750:METFOR_RS01190
uniprot id: L0HE00
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS02100
gene id: 593750:METFOR_RS02100
uniprot id: L0HCF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

593750:METFOR RS05300
gene id: 593750:METFOR_RS05300
uniprot id: L0HGA6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

593750:METFOR RS02950
gene id: 593750:METFOR_RS02950
uniprot id: L0HA72
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

593750:METFOR RS05340
gene id: 593750:METFOR_RS05340
uniprot id: L0HDN1
names: Similarity
messages: Belongs to the SUI1 family.

593750:METFOR RS08415
gene id: 593750:METFOR_RS08415
uniprot id: L0HI47
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS09210
gene id: 593750:METFOR_RS09210
uniprot id: L0HGH7
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS03035
gene id: 593750:METFOR_RS03035
uniprot id: L0HEE2
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

593750:METFOR RS11110
gene id: 593750:METFOR_RS11110
uniprot id: L0HEY0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS08815
gene id: 593750:METFOR_RS08815
uniprot id: L0HFN8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593750:METFOR RS08345
gene id: 593750:METFOR_RS08345
uniprot id: L0HI35
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS06315
gene id: 593750:METFOR_RS06315
uniprot id: L0HE81
names: Similarity
messages: Belongs to the HisA/HisF family.

593750:METFOR RS10005
gene id: 593750:METFOR_RS10005
uniprot id: L0HE96
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

593750:METFOR RS06660
gene id: 593750:METFOR_RS06660
uniprot id: L0HH31
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

593750:METFOR RS13090
gene id: 593750:METFOR_RS13090
uniprot id: L0HIT7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

593750:METFOR RS13840
gene id: 593750:METFOR_RS13840
uniprot id: L0HIG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

593750:METFOR RS02495
gene id: 593750:METFOR_RS02495
uniprot id: L0HE20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS03910
gene id: 593750:METFOR_RS03910
uniprot id: L0HCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

593750:METFOR RS11295
gene id: 593750:METFOR_RS11295
uniprot id: L0HJ31
names: Similarity
messages: Belongs to the MtxX family.

593750:METFOR RS06095
gene id: 593750:METFOR_RS06095
uniprot id: L0HE43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS00930
gene id: 593750:METFOR_RS00930
uniprot id: L0H963
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS02390
gene id: 593750:METFOR_RS02390
uniprot id: L0HEL4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS01845
gene id: 593750:METFOR_RS01845
uniprot id: L0H9L9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS04990
gene id: 593750:METFOR_RS04990
uniprot id: L0HFF9
names: Similarity
messages: Belongs to the eIF-2-alpha family.

593750:METFOR RS11115
gene id: 593750:METFOR_RS11115
uniprot id: L0HIZ9
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01305
gene id: 593750:METFOR_RS01305
uniprot id: L0HBE9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

593750:METFOR RS12685
gene id: 593750:METFOR_RS12685
uniprot id: L0HJW2
names: Similarity
messages: Belongs to the HdrC family.

593750:METFOR RS01290
gene id: 593750:METFOR_RS01290
uniprot id: L0H9C0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593750:METFOR RS14095
gene id: 593750:METFOR_RS14095
uniprot id: L0HIL2
names: Similarity
messages: Belongs to the TrpF family.

593750:METFOR RS06595
gene id: 593750:METFOR_RS06595
uniprot id: L0HEC7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

593750:METFOR RS03855
gene id: 593750:METFOR_RS03855
uniprot id: L0HFH1
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12350
gene id: 593750:METFOR_RS12350
uniprot id: L0HIB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

593750:METFOR RS05800
gene id: 593750:METFOR_RS05800
uniprot id: L0HDY9
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

593750:METFOR RS08160
gene id: 593750:METFOR_RS08160
uniprot id: L0HDA7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

593750:METFOR RS03300
gene id: 593750:METFOR_RS03300
uniprot id: L0HCI4
names: Similarity
messages: Belongs to the FwdC/FmdC family.

593750:METFOR RS05040
gene id: 593750:METFOR_RS05040
uniprot id: L0HG43
names: Function
messages: Part of a potassium transport system.

593750:METFOR RS11285
gene id: 593750:METFOR_RS11285
uniprot id: L0HHR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

593750:METFOR RS05530
gene id: 593750:METFOR_RS05530
uniprot id: L0HFT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

593750:METFOR RS06175
gene id: 593750:METFOR_RS06175
uniprot id: L0HC29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

593750:METFOR RS00385
gene id: 593750:METFOR_RS00385
uniprot id: L0H8W6
names: Similarity
messages: Belongs to the peptidase S13 family.

593750:METFOR RS05535
gene id: 593750:METFOR_RS05535
uniprot id: L0HGH3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

593750:METFOR RS00425
gene id: 593750:METFOR_RS00425
uniprot id: L0HB09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

593750:METFOR RS04435
gene id: 593750:METFOR_RS04435
uniprot id: L0HFT0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04785
gene id: 593750:METFOR_RS04785
uniprot id: L0HFZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

593750:METFOR RS12850
gene id: 593750:METFOR_RS12850
uniprot id: L0HFV6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

593750:METFOR RS06880
gene id: 593750:METFOR_RS06880
uniprot id: L0HEH7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS13085
gene id: 593750:METFOR_RS13085
uniprot id: L0HI29
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS00885
gene id: 593750:METFOR_RS00885
uniprot id: L0H956
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

593750:METFOR RS07605
gene id: 593750:METFOR_RS07605
uniprot id: L0HHL4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

593750:METFOR RS05805
gene id: 593750:METFOR_RS05805
uniprot id: L0HEL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

593750:METFOR RS01175
gene id: 593750:METFOR_RS01175
uniprot id: L0HBY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

593750:METFOR RS04015
gene id: 593750:METFOR_RS04015
uniprot id: L0HDJ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

593750:METFOR RS00100
gene id: 593750:METFOR_RS00100
uniprot id: L0HCS8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

593750:METFOR RS11375
gene id: 593750:METFOR_RS11375
uniprot id: L0HJT4
names: Similarity
messages: Belongs to the class-I fumarase family.

593750:METFOR RS02955
gene id: 593750:METFOR_RS02955
uniprot id: L0HEB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

593750:METFOR RS11160
gene id: 593750:METFOR_RS11160
uniprot id: L0HEY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS05570
gene id: 593750:METFOR_RS05570
uniprot id: L0HEH9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

593750:METFOR RS05035
gene id: 593750:METFOR_RS05035
uniprot id: L0HFG8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

593750:METFOR RS12960
gene id: 593750:METFOR_RS12960
uniprot id: L0HKS1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

593750:METFOR RS13505
gene id: 593750:METFOR_RS13505
uniprot id: L0HIA8
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS08700
gene id: 593750:METFOR_RS08700
uniprot id: L0HFL6
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

593750:METFOR RS01005
gene id: 593750:METFOR_RS01005
uniprot id: L0H973
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

593750:METFOR RS01605
gene id: 593750:METFOR_RS01605
uniprot id: L0HDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

593750:METFOR RS10290
gene id: 593750:METFOR_RS10290
uniprot id: L0HH61
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS05655
gene id: 593750:METFOR_RS05655
uniprot id: L0HFV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

593750:METFOR RS04330
gene id: 593750:METFOR_RS04330
uniprot id: L0HF28
names: Function
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

593750:METFOR RS12765
gene id: 593750:METFOR_RS12765
uniprot id: L0HHV5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

593750:METFOR RS09750
gene id: 593750:METFOR_RS09750
uniprot id: L0HG52
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593750:METFOR RS13155
gene id: 593750:METFOR_RS13155
uniprot id: L0HKW0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

593750:METFOR RS08915
gene id: 593750:METFOR_RS08915
uniprot id: L0HID9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

593750:METFOR RS10875
gene id: 593750:METFOR_RS10875
uniprot id: L0HIV0
names: Similarity
messages: Belongs to the UPF0147 family.

593750:METFOR RS03095
gene id: 593750:METFOR_RS03095
uniprot id: L0HCE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS13945
gene id: 593750:METFOR_RS13945
uniprot id: L0HJ85
names: Similarity
messages: Belongs to the phosphohexose mutase family.

593750:METFOR RS05125
gene id: 593750:METFOR_RS05125
uniprot id: L0HG61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593750:METFOR RS02160
gene id: 593750:METFOR_RS02160
uniprot id: L0HDU5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

593750:METFOR RS12575
gene id: 593750:METFOR_RS12575
uniprot id: L0HHR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

593750:METFOR RS05775
gene id: 593750:METFOR_RS05775
uniprot id: L0HDY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593750:METFOR RS00780
gene id: 593750:METFOR_RS00780
uniprot id: L0H941
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

593750:METFOR RS07240
gene id: 593750:METFOR_RS07240
uniprot id: L0HCN9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

593750:METFOR RS05695
gene id: 593750:METFOR_RS05695
uniprot id: L0HEK1
names: Similarity
messages: Belongs to the NodU/CmcH family.

593750:METFOR RS12525
gene id: 593750:METFOR_RS12525
uniprot id: L0HHQ2
names: Similarity
messages: Belongs to the NAPRTase family.

593750:METFOR RS13245
gene id: 593750:METFOR_RS13245
uniprot id: L0HI61
names: Similarity
messages: Belongs to the FrhG family.

593750:METFOR RS12910
gene id: 593750:METFOR_RS12910
uniprot id: L0HKR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593750:METFOR RS05440
gene id: 593750:METFOR_RS05440
uniprot id: L0HDQ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

593750:METFOR RS10555
gene id: 593750:METFOR_RS10555
uniprot id: L0HJE1
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

593750:METFOR RS10585
gene id: 593750:METFOR_RS10585
uniprot id: L0HGQ4
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

593750:METFOR RS07580
gene id: 593750:METFOR_RS07580
uniprot id: L0HGX0
names: Similarity
messages: Belongs to the AAA ATPase family.

593750:METFOR RS01775
gene id: 593750:METFOR_RS01775
uniprot id: L0HBL9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

593750:METFOR RS06115
gene id: 593750:METFOR_RS06115
uniprot id: L0HGT0
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

593750:METFOR RS04660
gene id: 593750:METFOR_RS04660
uniprot id: L0HD86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

593750:METFOR RS00950
gene id: 593750:METFOR_RS00950
uniprot id: L0HBU1
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS07135
gene id: 593750:METFOR_RS07135
uniprot id: L0HFA4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

593750:METFOR RS02550
gene id: 593750:METFOR_RS02550
uniprot id: L0HEP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS12440
gene id: 593750:METFOR_RS12440
uniprot id: L0HJQ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

593750:METFOR RS12920
gene id: 593750:METFOR_RS12920
uniprot id: L0HIN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

593750:METFOR RS06225
gene id: 593750:METFOR_RS06225
uniprot id: L0HC38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

593750:METFOR RS09225
gene id: 593750:METFOR_RS09225
uniprot id: L0HIJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

593750:METFOR RS11255
gene id: 593750:METFOR_RS11255
uniprot id: L0HH20
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS07430
gene id: 593750:METFOR_RS07430
uniprot id: L0HGT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

593750:METFOR RS13485
gene id: 593750:METFOR_RS13485
uniprot id: L0HJ03
names: Similarity
messages: Belongs to the UPF0251 family.

593750:METFOR RS12300
gene id: 593750:METFOR_RS12300
uniprot id: L0HIA6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

593750:METFOR RS13405
gene id: 593750:METFOR_RS13405
uniprot id: L0HL02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS10245
gene id: 593750:METFOR_RS10245
uniprot id: L0HED5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS06320
gene id: 593750:METFOR_RS06320
uniprot id: L0HEW0
names: Similarity
messages: Belongs to the thymidylate kinase family.

593750:METFOR RS04645
gene id: 593750:METFOR_RS04645
uniprot id: L0HB59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

593750:METFOR RS12445
gene id: 593750:METFOR_RS12445
uniprot id: L0HKE9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

593750:METFOR RS10450
gene id: 593750:METFOR_RS10450
uniprot id: L0HEH3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

593750:METFOR RS03200
gene id: 593750:METFOR_RS03200
uniprot id: L0HCG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

593750:METFOR RS06550
gene id: 593750:METFOR_RS06550
uniprot id: L0HEZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS09965
gene id: 593750:METFOR_RS09965
uniprot id: L0HIX8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

593750:METFOR RS06280
gene id: 593750:METFOR_RS06280
uniprot id: L0HG63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

593750:METFOR RS05060
gene id: 593750:METFOR_RS05060
uniprot id: L0HFH3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

593750:METFOR RS01815
gene id: 593750:METFOR_RS01815
uniprot id: L0H9L5
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS14455
gene id: 593750:METFOR_RS14455
uniprot id: L0HAW7
names: Similarity
messages: Belongs to the acylphosphatase family.

593750:METFOR RS13325
gene id: 593750:METFOR_RS13325
uniprot id: L0HIX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

593750:METFOR RS11955
gene id: 593750:METFOR_RS11955
uniprot id: L0HK49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

593750:METFOR RS11300
gene id: 593750:METFOR_RS11300
uniprot id: L0HJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

593750:METFOR RS10790
gene id: 593750:METFOR_RS10790
uniprot id: L0HGT7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS09670
gene id: 593750:METFOR_RS09670
uniprot id: L0HG37
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS03380
gene id: 593750:METFOR_RS03380
uniprot id: L0HD79
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

593750:METFOR RS00865
gene id: 593750:METFOR_RS00865
uniprot id: L0HD65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

593750:METFOR RS02960
gene id: 593750:METFOR_RS02960
uniprot id: L0HEX9
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

593750:METFOR RS11190
gene id: 593750:METFOR_RS11190
uniprot id: L0HJ13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

593750:METFOR RS10455
gene id: 593750:METFOR_RS10455
uniprot id: L0HIL1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

593750:METFOR RS12600
gene id: 593750:METFOR_RS12600
uniprot id: L0HHR9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS08000
gene id: 593750:METFOR_RS08000
uniprot id: L0HF90
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

593750:METFOR RS12760
gene id: 593750:METFOR_RS12760
uniprot id: L0HKM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

593750:METFOR RS06235
gene id: 593750:METFOR_RS06235
uniprot id: L0HGV4
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

593750:METFOR RS12900
gene id: 593750:METFOR_RS12900
uniprot id: L0HFW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

593750:METFOR RS00565
gene id: 593750:METFOR_RS00565
uniprot id: L0H906
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

593750:METFOR RS01685
gene id: 593750:METFOR_RS01685
uniprot id: L0HE92
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

593750:METFOR RS13520
gene id: 593750:METFOR_RS13520
uniprot id: L0HKB4
names: Similarity
messages: Belongs to the DtxR/MntR family.

593750:METFOR RS08235
gene id: 593750:METFOR_RS08235
uniprot id: L0HFZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

593750:METFOR RS08155
gene id: 593750:METFOR_RS08155
uniprot id: L0HFY9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12105
gene id: 593750:METFOR_RS12105
uniprot id: L0HJH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS00115
gene id: 593750:METFOR_RS00115
uniprot id: L0HBD0
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

593750:METFOR RS04320
gene id: 593750:METFOR_RS04320
uniprot id: L0HDQ1
names: Similarity
messages: Belongs to the HMD family.

593750:METFOR RS05650
gene id: 593750:METFOR_RS05650
uniprot id: L0HBT4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

593750:METFOR RS01160
gene id: 593750:METFOR_RS01160
uniprot id: L0HDB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12840
gene id: 593750:METFOR_RS12840
uniprot id: L0HHW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

593750:METFOR RS14020
gene id: 593750:METFOR_RS14020
uniprot id: L0HJA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

593750:METFOR RS04625
gene id: 593750:METFOR_RS04625
uniprot id: L0HF85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593750:METFOR RS01300
gene id: 593750:METFOR_RS01300
uniprot id: L0HE21
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

593750:METFOR RS09015
gene id: 593750:METFOR_RS09015
uniprot id: L0HIF5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

593750:METFOR RS03485
gene id: 593750:METFOR_RS03485
uniprot id: L0HEL5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

593750:METFOR RS02505
gene id: 593750:METFOR_RS02505
uniprot id: L0HC14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

593750:METFOR RS10480
gene id: 593750:METFOR_RS10480
uniprot id: L0HIL6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12375
gene id: 593750:METFOR_RS12375
uniprot id: L0HIC2
names: Similarity
messages: Belongs to the UPF0285 family.

593750:METFOR RS10560
gene id: 593750:METFOR_RS10560
uniprot id: L0HGP9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

593750:METFOR RS01655
gene id: 593750:METFOR_RS01655
uniprot id: L0HDK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

593750:METFOR RS05815
gene id: 593750:METFOR_RS05815
uniprot id: L0HFY3
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

593750:METFOR RS09255
gene id: 593750:METFOR_RS09255
uniprot id: L0HFV3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

593750:METFOR RS10855
gene id: 593750:METFOR_RS10855
uniprot id: L0HJI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

593750:METFOR RS04350
gene id: 593750:METFOR_RS04350
uniprot id: L0HAZ8
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

593750:METFOR RS14060
gene id: 593750:METFOR_RS14060
uniprot id: L0HKL1
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

593750:METFOR RS07820
gene id: 593750:METFOR_RS07820
uniprot id: L0HHR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

593750:METFOR RS04420
gene id: 593750:METFOR_RS04420
uniprot id: L0HDS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS10165
gene id: 593750:METFOR_RS10165
uniprot id: L0HEC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

593750:METFOR RS02515
gene id: 593750:METFOR_RS02515
uniprot id: L0H9Z7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS08710
gene id: 593750:METFOR_RS08710
uniprot id: L0HDK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

593750:METFOR RS05925
gene id: 593750:METFOR_RS05925
uniprot id: L0HGP3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

593750:METFOR RS12385
gene id: 593750:METFOR_RS12385
uniprot id: L0HJP3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593750:METFOR RS11825
gene id: 593750:METFOR_RS11825
uniprot id: L0HI09
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS11320
gene id: 593750:METFOR_RS11320
uniprot id: L0HJ36
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

593750:METFOR RS12580
gene id: 593750:METFOR_RS12580
uniprot id: L0HIG3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS12715
gene id: 593750:METFOR_RS12715
uniprot id: L0HKL4
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

593750:METFOR RS06990
gene id: 593750:METFOR_RS06990
uniprot id: L0HGJ8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

593750:METFOR RS09980
gene id: 593750:METFOR_RS09980
uniprot id: L0HE90
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

593750:METFOR RS14005
gene id: 593750:METFOR_RS14005
uniprot id: L0HKK1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

593750:METFOR RS12310
gene id: 593750:METFOR_RS12310
uniprot id: L0HJM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

593750:METFOR RS09010
gene id: 593750:METFOR_RS09010
uniprot id: L0HHR0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12110
gene id: 593750:METFOR_RS12110
uniprot id: L0HK75
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04950
gene id: 593750:METFOR_RS04950
uniprot id: L0HDE9
names: Similarity
messages: Belongs to the UPF0179 family.

593750:METFOR RS11340
gene id: 593750:METFOR_RS11340
uniprot id: L0HF15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

593750:METFOR RS12075
gene id: 593750:METFOR_RS12075
uniprot id: L0HJH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

593750:METFOR RS07440
gene id: 593750:METFOR_RS07440
uniprot id: L0HET7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

593750:METFOR RS12270
gene id: 593750:METFOR_RS12270
uniprot id: L0HHJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

593750:METFOR RS14015
gene id: 593750:METFOR_RS14015
uniprot id: L0HIJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

593750:METFOR RS06425
gene id: 593750:METFOR_RS06425
uniprot id: L0HGY9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

593750:METFOR RS03650
gene id: 593750:METFOR_RS03650
uniprot id: L0HAM6
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

593750:METFOR RS03545
gene id: 593750:METFOR_RS03545
uniprot id: L0HCM8
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS03765
gene id: 593750:METFOR_RS03765
uniprot id: L0HDE8
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

593750:METFOR RS08910
gene id: 593750:METFOR_RS08910
uniprot id: L0HHP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

593750:METFOR RS06400
gene id: 593750:METFOR_RS06400
uniprot id: L0HGY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

593750:METFOR RS14100
gene id: 593750:METFOR_RS14100
uniprot id: L0HJA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

593750:METFOR RS04525
gene id: 593750:METFOR_RS04525
uniprot id: L0HB31
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS01085
gene id: 593750:METFOR_RS01085
uniprot id: L0HDY5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

593750:METFOR RS06460
gene id: 593750:METFOR_RS06460
uniprot id: L0HEY6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

593750:METFOR RS08220
gene id: 593750:METFOR_RS08220
uniprot id: L0HHB9
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

593750:METFOR RS06625
gene id: 593750:METFOR_RS06625
uniprot id: L0HF09
names: Similarity
messages: Belongs to the UPF0215 family.

593750:METFOR RS01515
gene id: 593750:METFOR_RS01515
uniprot id: L0HBI0
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS00470
gene id: 593750:METFOR_RS00470
uniprot id: L0HDN3
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS12040
gene id: 593750:METFOR_RS12040
uniprot id: L0HK64
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593750:METFOR RS04640
gene id: 593750:METFOR_RS04640
uniprot id: L0HDW7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

593750:METFOR RS12615
gene id: 593750:METFOR_RS12615
uniprot id: L0HJU7
names: Subcellular Location Annotation
messages: Membrane

593750:METFOR RS04405
gene id: 593750:METFOR_RS04405
uniprot id: L0HF43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593750:METFOR RS11935
gene id: 593750:METFOR_RS11935
uniprot id: L0HK43
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593750:METFOR RS04915
gene id: 593750:METFOR_RS04915
uniprot id: L0HFE3
names: Similarity
messages: Belongs to the acylphosphatase family.