593117:TGAM RS08400
gene id: 593117:TGAM_RS08400
uniprot id: C5A7E9
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

593117:TGAM RS10155
gene id: 593117:TGAM_RS10155
uniprot id: C5A283
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

593117:TGAM RS08470
gene id: 593117:TGAM_RS08470
uniprot id: C5A7G2
names: Similarity
messages: Belongs to the UPF0166 family.

593117:TGAM RS00380
gene id: 593117:TGAM_RS00380
uniprot id: C5A2S5
names: Similarity
messages: Belongs to the MoaD family.

593117:TGAM RS06430
gene id: 593117:TGAM_RS06430
uniprot id: C5A6B0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS06350
gene id: 593117:TGAM_RS06350
uniprot id: C5A693
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

593117:TGAM RS01250
gene id: 593117:TGAM_RS01250
uniprot id: C5A3D7
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS02415
gene id: 593117:TGAM_RS02415
uniprot id: C5A416
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

593117:TGAM RS02275
gene id: 593117:TGAM_RS02275
uniprot id: C5A3Y6
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

593117:TGAM RS09815
gene id: 593117:TGAM_RS09815
uniprot id: C5A220
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

593117:TGAM RS04790
gene id: 593117:TGAM_RS04790
uniprot id: C5A5C9
names: Similarity
messages: Belongs to the UPF0045 family.

593117:TGAM RS01765
gene id: 593117:TGAM_RS01765
uniprot id: C5A3N8
names: Similarity
messages: Belongs to the UPF0215 family.

593117:TGAM RS09980
gene id: 593117:TGAM_RS09980
uniprot id: C5A248
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

593117:TGAM RS05425
gene id: 593117:TGAM_RS05425
uniprot id: C5A5Q9
names: Similarity
messages: Belongs to the peptidase C56 family.

593117:TGAM RS09275
gene id: 593117:TGAM_RS09275
uniprot id: C5A1R7
names: Similarity
messages: Belongs to the peptidase M24B family.

593117:TGAM RS08060
gene id: 593117:TGAM_RS08060
uniprot id: C5A782
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

593117:TGAM RS08275
gene id: 593117:TGAM_RS08275
uniprot id: C5A7C4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

593117:TGAM RS06960
gene id: 593117:TGAM_RS06960
uniprot id: C5A6L5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS07770
gene id: 593117:TGAM_RS07770
uniprot id: C5A724
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

593117:TGAM RS07075
gene id: 593117:TGAM_RS07075
uniprot id: C5A6N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

593117:TGAM RS04590
gene id: 593117:TGAM_RS04590
uniprot id: C5A590
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS01675
gene id: 593117:TGAM_RS01675
uniprot id: C5A3M0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

593117:TGAM RS00225
gene id: 593117:TGAM_RS00225
uniprot id: C5A2P4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS05530
gene id: 593117:TGAM_RS05530
uniprot id: C5A5T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

593117:TGAM RS09245
gene id: 593117:TGAM_RS09245
uniprot id: C5A1R1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

593117:TGAM RS02400
gene id: 593117:TGAM_RS02400
uniprot id: C5A413
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

593117:TGAM RS03575
gene id: 593117:TGAM_RS03575
uniprot id: C5A4N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

593117:TGAM RS00720
gene id: 593117:TGAM_RS00720
uniprot id: C5A331
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

593117:TGAM RS08155
gene id: 593117:TGAM_RS08155
uniprot id: C5A7A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

593117:TGAM RS00945
gene id: 593117:TGAM_RS00945
uniprot id: C5A377
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

593117:TGAM RS02465
gene id: 593117:TGAM_RS02465
uniprot id: C5A424
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

593117:TGAM RS01380
gene id: 593117:TGAM_RS01380
uniprot id: C5A3G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

593117:TGAM RS10100
gene id: 593117:TGAM_RS10100
uniprot id: C5A272
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

593117:TGAM RS01740
gene id: 593117:TGAM_RS01740
uniprot id: C5A3N3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

593117:TGAM RS06250
gene id: 593117:TGAM_RS06250
uniprot id: C5A673
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS07845
gene id: 593117:TGAM_RS07845
uniprot id: C5A739
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

593117:TGAM RS04465
gene id: 593117:TGAM_RS04465
uniprot id: C5A565
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS08270
gene id: 593117:TGAM_RS08270
uniprot id: C5A7C3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

593117:TGAM RS08070
gene id: 593117:TGAM_RS08070
uniprot id: C5A784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

593117:TGAM RS10625
gene id: 593117:TGAM_RS10625
uniprot id: C5A2H5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

593117:TGAM RS06545
gene id: 593117:TGAM_RS06545
uniprot id: C5A6D3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

593117:TGAM RS06400
gene id: 593117:TGAM_RS06400
uniprot id: C5A6A3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS03745
gene id: 593117:TGAM_RS03745
uniprot id: C5A4S1
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

593117:TGAM RS02885
gene id: 593117:TGAM_RS02885
uniprot id: C5A4A5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

593117:TGAM RS07875
gene id: 593117:TGAM_RS07875
uniprot id: C5A745
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

593117:TGAM RS09735
gene id: 593117:TGAM_RS09735
uniprot id: C5A205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

593117:TGAM RS05145
gene id: 593117:TGAM_RS05145
uniprot id: C5A5K1
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

593117:TGAM RS06310
gene id: 593117:TGAM_RS06310
uniprot id: C5A685
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS08945
gene id: 593117:TGAM_RS08945
uniprot id: C5A1K3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

593117:TGAM RS10495
gene id: 593117:TGAM_RS10495
uniprot id: C5A2E8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593117:TGAM RS04105
gene id: 593117:TGAM_RS04105
uniprot id: C5A4Z4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

593117:TGAM RS05105
gene id: 593117:TGAM_RS05105
uniprot id: C5A5J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593117:TGAM RS08605
gene id: 593117:TGAM_RS08605
uniprot id: C5A7J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

593117:TGAM RS00645
gene id: 593117:TGAM_RS00645
uniprot id: C5A316
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

593117:TGAM RS02605
gene id: 593117:TGAM_RS02605
uniprot id: C5A450
names: Similarity
messages: Belongs to the band 7/mec-2 family.

593117:TGAM RS02470
gene id: 593117:TGAM_RS02470
uniprot id: C5A425
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

593117:TGAM RS01275
gene id: 593117:TGAM_RS01275
uniprot id: C5A3E2
names: Similarity
messages: Belongs to the HupF/HypC family.

593117:TGAM RS10470
gene id: 593117:TGAM_RS10470
uniprot id: C5A2E3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

593117:TGAM RS01950
gene id: 593117:TGAM_RS01950
uniprot id: C5A3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS06130
gene id: 593117:TGAM_RS06130
uniprot id: C5A649
names: Similarity
messages: Belongs to the UPF0248 family.

593117:TGAM RS01890
gene id: 593117:TGAM_RS01890
uniprot id: C5A3R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

593117:TGAM RS10210
gene id: 593117:TGAM_RS10210
uniprot id: C5A295
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

593117:TGAM RS10350
gene id: 593117:TGAM_RS10350
uniprot id: C5A2C2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

593117:TGAM RS10720
gene id: 593117:TGAM_RS10720
uniprot id: C5A2J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

593117:TGAM RS05300
gene id: 593117:TGAM_RS05300
uniprot id: C5A5N3
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

593117:TGAM RS01625
gene id: 593117:TGAM_RS01625
uniprot id: C5A3L1
names: Similarity
messages: Belongs to the UPF0111 family.

593117:TGAM RS00650
gene id: 593117:TGAM_RS00650
uniprot id: C5A317
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

593117:TGAM RS04285
gene id: 593117:TGAM_RS04285
uniprot id: C5A530
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS09355
gene id: 593117:TGAM_RS09355
uniprot id: C5A1T1
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

593117:TGAM RS09935
gene id: 593117:TGAM_RS09935
uniprot id: C5A241
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

593117:TGAM RS09775
gene id: 593117:TGAM_RS09775
uniprot id: C5A212
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

593117:TGAM RS07120
gene id: 593117:TGAM_RS07120
uniprot id: C5A6P6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

593117:TGAM RS03835
gene id: 593117:TGAM_RS03835
uniprot id: C5A4U0
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

593117:TGAM RS10450
gene id: 593117:TGAM_RS10450
uniprot id: C5A2D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

593117:TGAM RS05620
gene id: 593117:TGAM_RS05620
uniprot id: C5A5U8
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

593117:TGAM RS00325
gene id: 593117:TGAM_RS00325
uniprot id: C5A2R4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

593117:TGAM RS10060
gene id: 593117:TGAM_RS10060
uniprot id: C5A264
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

593117:TGAM RS04675
gene id: 593117:TGAM_RS04675
uniprot id: C5A5A7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

593117:TGAM RS10840
gene id: 593117:TGAM_RS10840
uniprot id: C5A2X8
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

593117:TGAM RS10520
gene id: 593117:TGAM_RS10520
uniprot id: C5A2F3
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

593117:TGAM RS03035
gene id: 593117:TGAM_RS03035
uniprot id: C5A4D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593117:TGAM RS01760
gene id: 593117:TGAM_RS01760
uniprot id: C5A3N7
names: Similarity
messages: Belongs to the CutA family.

593117:TGAM RS00205
gene id: 593117:TGAM_RS00205
uniprot id: C5A2P0
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS07895
gene id: 593117:TGAM_RS07895
uniprot id: C5A749
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS02490
gene id: 593117:TGAM_RS02490
uniprot id: C5A429
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

593117:TGAM RS09510
gene id: 593117:TGAM_RS09510
uniprot id: C5A1W3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS10595
gene id: 593117:TGAM_RS10595
uniprot id: C5A2G9
names: Similarity
messages: Belongs to the UPF0047 family.

593117:TGAM RS01865
gene id: 593117:TGAM_RS01865
uniprot id: C5A3Q6
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

593117:TGAM RS08660
gene id: 593117:TGAM_RS08660
uniprot id: C5A7K3
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

593117:TGAM RS03645
gene id: 593117:TGAM_RS03645
uniprot id: C5A4Q1
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10105
gene id: 593117:TGAM_RS10105
uniprot id: C5A273
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

593117:TGAM RS06425
gene id: 593117:TGAM_RS06425
uniprot id: C5A6A9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

593117:TGAM RS04265
gene id: 593117:TGAM_RS04265
uniprot id: C5A526
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03065
gene id: 593117:TGAM_RS03065
uniprot id: C5A4E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS05850
gene id: 593117:TGAM_RS05850
uniprot id: C5A5Z1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

593117:TGAM RS09105
gene id: 593117:TGAM_RS09105
uniprot id: C5A1N3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

593117:TGAM RS03985
gene id: 593117:TGAM_RS03985
uniprot id: C5A4X2
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS04085
gene id: 593117:TGAM_RS04085
uniprot id: C5A4Z0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

593117:TGAM RS09145
gene id: 593117:TGAM_RS09145
uniprot id: C5A1P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

593117:TGAM RS00840
gene id: 593117:TGAM_RS00840
uniprot id: C5A355
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

593117:TGAM RS03895
gene id: 593117:TGAM_RS03895
uniprot id: C5A4V2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

593117:TGAM RS07850
gene id: 593117:TGAM_RS07850
uniprot id: C5A740
names: Similarity
messages: Belongs to the pyruvate kinase family.

593117:TGAM RS00160
gene id: 593117:TGAM_RS00160
uniprot id: C5A2N1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

593117:TGAM RS04205
gene id: 593117:TGAM_RS04205
uniprot id: C5A514
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

593117:TGAM RS06845
gene id: 593117:TGAM_RS06845
uniprot id: C5A6J2
names: Similarity
messages: Belongs to the peptidase U62 family.

593117:TGAM RS06805
gene id: 593117:TGAM_RS06805
uniprot id: C5A6I4
names: Similarity
messages: Belongs to the UPF0212 family.

593117:TGAM RS08295
gene id: 593117:TGAM_RS08295
uniprot id: C5A7C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

593117:TGAM RS04160
gene id: 593117:TGAM_RS04160
uniprot id: C5A505
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

593117:TGAM RS03710
gene id: 593117:TGAM_RS03710
uniprot id: C5A4R4
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

593117:TGAM RS05335
gene id: 593117:TGAM_RS05335
uniprot id: C5A5P1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS08915
gene id: 593117:TGAM_RS08915
uniprot id: C5A1J8
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

593117:TGAM RS05250
gene id: 593117:TGAM_RS05250
uniprot id: C5A5M3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

593117:TGAM RS10120
gene id: 593117:TGAM_RS10120
uniprot id: C5A276
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS09310
gene id: 593117:TGAM_RS09310
uniprot id: C5A1S2
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

593117:TGAM RS07660
gene id: 593117:TGAM_RS07660
uniprot id: C5A703
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

593117:TGAM RS06565
gene id: 593117:TGAM_RS06565
uniprot id: C5A6D7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

593117:TGAM RS09370
gene id: 593117:TGAM_RS09370
uniprot id: C5A1T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS05260
gene id: 593117:TGAM_RS05260
uniprot id: C5A5M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

593117:TGAM RS03045
gene id: 593117:TGAM_RS03045
uniprot id: C5A4D8
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

593117:TGAM RS02180
gene id: 593117:TGAM_RS02180
uniprot id: C5A3W7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

593117:TGAM RS06605
gene id: 593117:TGAM_RS06605
uniprot id: C5A6E5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

593117:TGAM RS10025
gene id: 593117:TGAM_RS10025
uniprot id: C5A257
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

593117:TGAM RS02725
gene id: 593117:TGAM_RS02725
uniprot id: C5A474
names: Similarity
messages: Belongs to the UPF0284 family.

593117:TGAM RS04060
gene id: 593117:TGAM_RS04060
uniprot id: C5A4Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

593117:TGAM RS08635
gene id: 593117:TGAM_RS08635
uniprot id: C5A7J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

593117:TGAM RS05660
gene id: 593117:TGAM_RS05660
uniprot id: C5A5V6
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03205
gene id: 593117:TGAM_RS03205
uniprot id: C5A4H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

593117:TGAM RS04480
gene id: 593117:TGAM_RS04480
uniprot id: C5A568
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

593117:TGAM RS05515
gene id: 593117:TGAM_RS05515
uniprot id: C5A5S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS01540
gene id: 593117:TGAM_RS01540
uniprot id: C5A3J5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

593117:TGAM RS05755
gene id: 593117:TGAM_RS05755
uniprot id: C5A5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

593117:TGAM RS05690
gene id: 593117:TGAM_RS05690
uniprot id: C5A5W1
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS00240
gene id: 593117:TGAM_RS00240
uniprot id: C5A2P7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS10135
gene id: 593117:TGAM_RS10135
uniprot id: C5A279
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

593117:TGAM RS00985
gene id: 593117:TGAM_RS00985
uniprot id: C5A385
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03060
gene id: 593117:TGAM_RS03060
uniprot id: C5A4E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS09480
gene id: 593117:TGAM_RS09480
uniprot id: C5A1V7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

593117:TGAM RS01550
gene id: 593117:TGAM_RS01550
uniprot id: C5A3J7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

593117:TGAM RS10125
gene id: 593117:TGAM_RS10125
uniprot id: C5A277
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593117:TGAM RS10005
gene id: 593117:TGAM_RS10005
uniprot id: C5A252
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

593117:TGAM RS10550
gene id: 593117:TGAM_RS10550
uniprot id: C5A2G0
names: Similarity
messages: Belongs to the threonine synthase family.

593117:TGAM RS09490
gene id: 593117:TGAM_RS09490
uniprot id: C5A1V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

593117:TGAM RS06325
gene id: 593117:TGAM_RS06325
uniprot id: C5A688
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS09600
gene id: 593117:TGAM_RS09600
uniprot id: C5A1Y1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

593117:TGAM RS07775
gene id: 593117:TGAM_RS07775
uniprot id: C5A725
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

593117:TGAM RS10610
gene id: 593117:TGAM_RS10610
uniprot id: C5A2H2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

593117:TGAM RS08805
gene id: 593117:TGAM_RS08805
uniprot id: C5A1H6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

593117:TGAM RS02480
gene id: 593117:TGAM_RS02480
uniprot id: C5A427
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

593117:TGAM RS07890
gene id: 593117:TGAM_RS07890
uniprot id: C5A748
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

593117:TGAM RS05900
gene id: 593117:TGAM_RS05900
uniprot id: C5A602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

593117:TGAM RS04775
gene id: 593117:TGAM_RS04775
uniprot id: C5A5C6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS08415
gene id: 593117:TGAM_RS08415
uniprot id: C5A7F1
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

593117:TGAM RS01180
gene id: 593117:TGAM_RS01180
uniprot id: C5A3C3
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

593117:TGAM RS07590
gene id: 593117:TGAM_RS07590
uniprot id: C5A6Z0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

593117:TGAM RS08940
gene id: 593117:TGAM_RS08940
uniprot id: C5A1K2
names: Similarity
messages: Belongs to the thymidylate kinase family.

593117:TGAM RS08555
gene id: 593117:TGAM_RS08555
uniprot id: C5A7H9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

593117:TGAM RS10090
gene id: 593117:TGAM_RS10090
uniprot id: C5A270
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS08140
gene id: 593117:TGAM_RS08140
uniprot id: C5A798
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

593117:TGAM RS00265
gene id: 593117:TGAM_RS00265
uniprot id: C5A2Q2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS10275
gene id: 593117:TGAM_RS10275
uniprot id: C5A2A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

593117:TGAM RS05880
gene id: 593117:TGAM_RS05880
uniprot id: C5A5Z7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

593117:TGAM RS10885
gene id: 593117:TGAM_RS10885
uniprot id: C5A2Y7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

593117:TGAM RS06815
gene id: 593117:TGAM_RS06815
uniprot id: C5A6I6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

593117:TGAM RS02145
gene id: 593117:TGAM_RS02145
uniprot id: C5A3W0
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

593117:TGAM RS07030
gene id: 593117:TGAM_RS07030
uniprot id: C5A6M8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

593117:TGAM RS01775
gene id: 593117:TGAM_RS01775
uniprot id: C5A3P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

593117:TGAM RS10695
gene id: 593117:TGAM_RS10695
uniprot id: C5A2I9
names: Similarity
messages: Belongs to the peptidase U62 family.

593117:TGAM RS07620
gene id: 593117:TGAM_RS07620
uniprot id: C5A6Z5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

593117:TGAM RS09455
gene id: 593117:TGAM_RS09455
uniprot id: C5A1V1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

593117:TGAM RS10200
gene id: 593117:TGAM_RS10200
uniprot id: C5A293
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

593117:TGAM RS09055
gene id: 593117:TGAM_RS09055
uniprot id: C5A1M3
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

593117:TGAM RS05355
gene id: 593117:TGAM_RS05355
uniprot id: C5A5P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS01755
gene id: 593117:TGAM_RS01755
uniprot id: C5A3N6
names: Similarity
messages: Belongs to the acylphosphatase family.

593117:TGAM RS02580
gene id: 593117:TGAM_RS02580
uniprot id: C5A445
names: Similarity
messages: Belongs to the UPF0128 family.

593117:TGAM RS10035
gene id: 593117:TGAM_RS10035
uniprot id: C5A259
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

593117:TGAM RS00740
gene id: 593117:TGAM_RS00740
uniprot id: C5A335
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593117:TGAM RS07650
gene id: 593117:TGAM_RS07650
uniprot id: C5A701
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

593117:TGAM RS02340
gene id: 593117:TGAM_RS02340
uniprot id: C5A401
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

593117:TGAM RS02185
gene id: 593117:TGAM_RS02185
uniprot id: C5A3W8
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

593117:TGAM RS01395
gene id: 593117:TGAM_RS01395
uniprot id: C5A3G6
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

593117:TGAM RS05410
gene id: 593117:TGAM_RS05410
uniprot id: C5A5Q6
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS00405
gene id: 593117:TGAM_RS00405
uniprot id: C5A2T0
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08445
gene id: 593117:TGAM_RS08445
uniprot id: C5A7F7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

593117:TGAM RS04430
gene id: 593117:TGAM_RS04430
uniprot id: C5A558
names: Similarity
messages: Belongs to the UPF0200 family.

593117:TGAM RS04370
gene id: 593117:TGAM_RS04370
uniprot id: C5A546
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

593117:TGAM RS01280
gene id: 593117:TGAM_RS01280
uniprot id: C5A3E3
names: Similarity
messages: Belongs to the HupF/HypC family.

593117:TGAM RS08135
gene id: 593117:TGAM_RS08135
uniprot id: C5A797
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

593117:TGAM RS09495
gene id: 593117:TGAM_RS09495
uniprot id: C5A1W0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

593117:TGAM RS07415
gene id: 593117:TGAM_RS07415
uniprot id: C5A6V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

593117:TGAM RS07535
gene id: 593117:TGAM_RS07535
uniprot id: C5A6X9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

593117:TGAM RS08965
gene id: 593117:TGAM_RS08965
uniprot id: C5A1K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

593117:TGAM RS01370
gene id: 593117:TGAM_RS01370
uniprot id: C5A3G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

593117:TGAM RS05675
gene id: 593117:TGAM_RS05675
uniprot id: C5A5V9
names: Similarity
messages: Belongs to the UPF0107 family.

593117:TGAM RS06080
gene id: 593117:TGAM_RS06080
uniprot id: C5A639
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

593117:TGAM RS09365
gene id: 593117:TGAM_RS09365
uniprot id: C5A1T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS09950
gene id: 593117:TGAM_RS09950
uniprot id: C5A243
names: Similarity
messages: Belongs to the enolase family.

593117:TGAM RS06860
gene id: 593117:TGAM_RS06860
uniprot id: C5A6J6
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

593117:TGAM RS03605
gene id: 593117:TGAM_RS03605
uniprot id: C5A4P3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS09615
gene id: 593117:TGAM_RS09615
uniprot id: C5A1Y4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

593117:TGAM RS03860
gene id: 593117:TGAM_RS03860
uniprot id: C5A4U5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

593117:TGAM RS06075
gene id: 593117:TGAM_RS06075
uniprot id: C5A638
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

593117:TGAM RS02475
gene id: 593117:TGAM_RS02475
uniprot id: C5A426
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

593117:TGAM RS06320
gene id: 593117:TGAM_RS06320
uniprot id: C5A687
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10525
gene id: 593117:TGAM_RS10525
uniprot id: C5A2F4
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

593117:TGAM RS08645
gene id: 593117:TGAM_RS08645
uniprot id: C5A7K0
names: Similarity
messages: Belongs to the P(II) protein family.

593117:TGAM RS09885
gene id: 593117:TGAM_RS09885
uniprot id: C5A233
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

593117:TGAM RS01800
gene id: 593117:TGAM_RS01800
uniprot id: C5A3P3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

593117:TGAM RS08725
gene id: 593117:TGAM_RS08725
uniprot id: C5A7L6
names: Similarity
messages: Belongs to the MEMO1 family.

593117:TGAM RS01045
gene id: 593117:TGAM_RS01045
uniprot id: C5A397
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

593117:TGAM RS01210
gene id: 593117:TGAM_RS01210
uniprot id: C5A3C9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

593117:TGAM RS04425
gene id: 593117:TGAM_RS04425
uniprot id: C5A557
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10415
gene id: 593117:TGAM_RS10415
uniprot id: C5A2D2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

593117:TGAM RS04440
gene id: 593117:TGAM_RS04440
uniprot id: C5A560
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

593117:TGAM RS00780
gene id: 593117:TGAM_RS00780
uniprot id: C5A343
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS10335
gene id: 593117:TGAM_RS10335
uniprot id: C5A2B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

593117:TGAM RS10510
gene id: 593117:TGAM_RS10510
uniprot id: C5A2F1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS08520
gene id: 593117:TGAM_RS08520
uniprot id: C5A7H2
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

593117:TGAM RS03280
gene id: 593117:TGAM_RS03280
uniprot id: C5A4I6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS00980
gene id: 593117:TGAM_RS00980
uniprot id: C5A384
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

593117:TGAM RS07905
gene id: 593117:TGAM_RS07905
uniprot id: C5A751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS01585
gene id: 593117:TGAM_RS01585
uniprot id: C5A3K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

593117:TGAM RS03245
gene id: 593117:TGAM_RS03245
uniprot id: C5A4H9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

593117:TGAM RS03630
gene id: 593117:TGAM_RS03630
uniprot id: C5A4P8
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08685
gene id: 593117:TGAM_RS08685
uniprot id: C5A7K8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

593117:TGAM RS03660
gene id: 593117:TGAM_RS03660
uniprot id: C5A4Q4
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

593117:TGAM RS05855
gene id: 593117:TGAM_RS05855
uniprot id: C5A5Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

593117:TGAM RS01990
gene id: 593117:TGAM_RS01990
uniprot id: C5A3T1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

593117:TGAM RS06025
gene id: 593117:TGAM_RS06025
uniprot id: C5A628
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

593117:TGAM RS07880
gene id: 593117:TGAM_RS07880
uniprot id: C5A746
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

593117:TGAM RS01460
gene id: 593117:TGAM_RS01460
uniprot id: C5A3H9
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS09110
gene id: 593117:TGAM_RS09110
uniprot id: C5A1N4
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS05825
gene id: 593117:TGAM_RS05825
uniprot id: C5A5Y6
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

593117:TGAM RS07275
gene id: 593117:TGAM_RS07275
uniprot id: C5A6S7
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03730
gene id: 593117:TGAM_RS03730
uniprot id: C5A4R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

593117:TGAM RS10145
gene id: 593117:TGAM_RS10145
uniprot id: C5A281
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

593117:TGAM RS02350
gene id: 593117:TGAM_RS02350
uniprot id: C5A403
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

593117:TGAM RS08160
gene id: 593117:TGAM_RS08160
uniprot id: C5A7A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

593117:TGAM RS10890
gene id: 593117:TGAM_RS10890
uniprot id: C5A2Y8
names: Similarity
messages: Belongs to the UDPGP type 2 family.

593117:TGAM RS02240
gene id: 593117:TGAM_RS02240
uniprot id: C5A3X9
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10710
gene id: 593117:TGAM_RS10710
uniprot id: C5A2J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS09025
gene id: 593117:TGAM_RS09025
uniprot id: C5A1L9
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

593117:TGAM RS03080
gene id: 593117:TGAM_RS03080
uniprot id: C5A4E5
names: Similarity
messages: Belongs to the UPF0146 family.

593117:TGAM RS09200
gene id: 593117:TGAM_RS09200
uniprot id: C5A1Q2
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS07840
gene id: 593117:TGAM_RS07840
uniprot id: C5A738
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

593117:TGAM RS10110
gene id: 593117:TGAM_RS10110
uniprot id: C5A274
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

593117:TGAM RS00755
gene id: 593117:TGAM_RS00755
uniprot id: C5A338
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593117:TGAM RS03620
gene id: 593117:TGAM_RS03620
uniprot id: C5A4P6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS02860
gene id: 593117:TGAM_RS02860
uniprot id: C5A4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS04635
gene id: 593117:TGAM_RS04635
uniprot id: C5A599
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

593117:TGAM RS06715
gene id: 593117:TGAM_RS06715
uniprot id: C5A6G5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS10295
gene id: 593117:TGAM_RS10295
uniprot id: C5A2B2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS04610
gene id: 593117:TGAM_RS04610
uniprot id: C5A594
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

593117:TGAM RS09135
gene id: 593117:TGAM_RS09135
uniprot id: C5A1N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

593117:TGAM RS05510
gene id: 593117:TGAM_RS05510
uniprot id: C5A5S6
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10430
gene id: 593117:TGAM_RS10430
uniprot id: C5A2D5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

593117:TGAM RS04415
gene id: 593117:TGAM_RS04415
uniprot id: C5A555
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS02200
gene id: 593117:TGAM_RS02200
uniprot id: C5A3X1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

593117:TGAM RS09795
gene id: 593117:TGAM_RS09795
uniprot id: C5A216
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

593117:TGAM RS01955
gene id: 593117:TGAM_RS01955
uniprot id: C5A3S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS02730
gene id: 593117:TGAM_RS02730
uniprot id: C5A475
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

593117:TGAM RS01355
gene id: 593117:TGAM_RS01355
uniprot id: C5A3F8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

593117:TGAM RS04400
gene id: 593117:TGAM_RS04400
uniprot id: C5A552
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

593117:TGAM RS01185
gene id: 593117:TGAM_RS01185
uniprot id: C5A3C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

593117:TGAM RS02355
gene id: 593117:TGAM_RS02355
uniprot id: C5A404
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

593117:TGAM RS02545
gene id: 593117:TGAM_RS02545
uniprot id: C5A438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

593117:TGAM RS01160
gene id: 593117:TGAM_RS01160
uniprot id: C5A3B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

593117:TGAM RS06575
gene id: 593117:TGAM_RS06575
uniprot id: C5A6D9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

593117:TGAM RS04130
gene id: 593117:TGAM_RS04130
uniprot id: C5A4Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

593117:TGAM RS10095
gene id: 593117:TGAM_RS10095
uniprot id: C5A271
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS05910
gene id: 593117:TGAM_RS05910
uniprot id: C5A604
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

593117:TGAM RS04690
gene id: 593117:TGAM_RS04690
uniprot id: C5A5B0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

593117:TGAM RS10795
gene id: 593117:TGAM_RS10795
uniprot id: C5A2W9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

593117:TGAM RS04460
gene id: 593117:TGAM_RS04460
uniprot id: C5A564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS03085
gene id: 593117:TGAM_RS03085
uniprot id: C5A4E6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

593117:TGAM RS08530
gene id: 593117:TGAM_RS08530
uniprot id: C5A7H4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

593117:TGAM RS03935
gene id: 593117:TGAM_RS03935
uniprot id: C5A4W1
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS09125
gene id: 593117:TGAM_RS09125
uniprot id: C5A1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

593117:TGAM RS07565
gene id: 593117:TGAM_RS07565
uniprot id: C5A6Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

593117:TGAM RS02140
gene id: 593117:TGAM_RS02140
uniprot id: C5A3V9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
messages: Homodimer.

593117:TGAM RS05965
gene id: 593117:TGAM_RS05965
uniprot id: C5A615
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

593117:TGAM RS02570
gene id: 593117:TGAM_RS02570
uniprot id: C5A443
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS05345
gene id: 593117:TGAM_RS05345
uniprot id: C5A5P3
names: Similarity
messages: Belongs to the NodU/CmcH family.

593117:TGAM RS06995
gene id: 593117:TGAM_RS06995
uniprot id: C5A6M1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS07855
gene id: 593117:TGAM_RS07855
uniprot id: C5A741
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

593117:TGAM RS03870
gene id: 593117:TGAM_RS03870
uniprot id: C5A4U7
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

593117:TGAM RS08450
gene id: 593117:TGAM_RS08450
uniprot id: C5A7F8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

593117:TGAM RS01685
gene id: 593117:TGAM_RS01685
uniprot id: C5A3M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS01330
gene id: 593117:TGAM_RS01330
uniprot id: C5A3F3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS07495
gene id: 593117:TGAM_RS07495
uniprot id: C5A6X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS08775
gene id: 593117:TGAM_RS08775
uniprot id: C5A1H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

593117:TGAM RS09900
gene id: 593117:TGAM_RS09900
uniprot id: C5A236
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

593117:TGAM RS05570
gene id: 593117:TGAM_RS05570
uniprot id: C5A5T8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

593117:TGAM RS03865
gene id: 593117:TGAM_RS03865
uniprot id: C5A4U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

593117:TGAM RS02420
gene id: 593117:TGAM_RS02420
uniprot id: C5A417
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

593117:TGAM RS10330
gene id: 593117:TGAM_RS10330
uniprot id: C5A2B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

593117:TGAM RS05795
gene id: 593117:TGAM_RS05795
uniprot id: C5A5Y0
names: Similarity
messages: Belongs to the HypE family.

593117:TGAM RS00280
gene id: 593117:TGAM_RS00280
uniprot id: C5A2Q5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS00495
gene id: 593117:TGAM_RS00495
uniprot id: C5A2U8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

593117:TGAM RS09740
gene id: 593117:TGAM_RS09740
uniprot id: C5A206
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

593117:TGAM RS05385
gene id: 593117:TGAM_RS05385
uniprot id: C5A5Q0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

593117:TGAM RS10000
gene id: 593117:TGAM_RS10000
uniprot id: C5A251
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

593117:TGAM RS10605
gene id: 593117:TGAM_RS10605
uniprot id: C5A2H1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

593117:TGAM RS07055
gene id: 593117:TGAM_RS07055
uniprot id: C5A6N3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

593117:TGAM RS02325
gene id: 593117:TGAM_RS02325
uniprot id: C5A3Z7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

593117:TGAM RS06590
gene id: 593117:TGAM_RS06590
uniprot id: C5A6E2
names: Similarity
messages: Belongs to the glutaredoxin family.

593117:TGAM RS01440
gene id: 593117:TGAM_RS01440
uniprot id: C5A3H5
names: Function
messages: Part of a potassium transport system.

593117:TGAM RS08500
gene id: 593117:TGAM_RS08500
uniprot id: C5A7G8
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

593117:TGAM RS01565
gene id: 593117:TGAM_RS01565
uniprot id: C5A3K0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

593117:TGAM RS09010
gene id: 593117:TGAM_RS09010
uniprot id: C5A1L6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

593117:TGAM RS04605
gene id: 593117:TGAM_RS04605
uniprot id: C5A593
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

593117:TGAM RS00855
gene id: 593117:TGAM_RS00855
uniprot id: C5A358
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

593117:TGAM RS05775
gene id: 593117:TGAM_RS05775
uniprot id: C5A5X7
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS05905
gene id: 593117:TGAM_RS05905
uniprot id: C5A603
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

593117:TGAM RS05650
gene id: 593117:TGAM_RS05650
uniprot id: C5A5V4
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03650
gene id: 593117:TGAM_RS03650
uniprot id: C5A4Q2
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

593117:TGAM RS01875
gene id: 593117:TGAM_RS01875
uniprot id: C5A3Q8
names: Similarity
messages: Belongs to the peptidase S8 family.

593117:TGAM RS00390
gene id: 593117:TGAM_RS00390
uniprot id: C5A2S7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

593117:TGAM RS06065
gene id: 593117:TGAM_RS06065
uniprot id: C5A636
names: Similarity
messages: Belongs to the PDCD5 family.

593117:TGAM RS01660
gene id: 593117:TGAM_RS01660
uniprot id: C5A3L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

593117:TGAM RS03000
gene id: 593117:TGAM_RS03000
uniprot id: C5A4C8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

593117:TGAM RS01385
gene id: 593117:TGAM_RS01385
uniprot id: C5A3G4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

593117:TGAM RS06300
gene id: 593117:TGAM_RS06300
uniprot id: C5A683
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS08975
gene id: 593117:TGAM_RS08975
uniprot id: C5A1L0
names: Cofactor
names: Similarity
messages: Belongs to the UPF0292 family.
messages: Binds two Mg(2+) per subunit.

593117:TGAM RS03685
gene id: 593117:TGAM_RS03685
uniprot id: C5A4Q9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS09750
gene id: 593117:TGAM_RS09750
uniprot id: C5A208
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593117:TGAM RS02560
gene id: 593117:TGAM_RS02560
uniprot id: C5A441
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

593117:TGAM RS02225
gene id: 593117:TGAM_RS02225
uniprot id: C5A3X6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

593117:TGAM RS09565
gene id: 593117:TGAM_RS09565
uniprot id: C5A1X4
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Belongs to the SIS family. PHI subfamily.

593117:TGAM RS01285
gene id: 593117:TGAM_RS01285
uniprot id: C5A3E4
names: Similarity
messages: Belongs to the HypD family.

593117:TGAM RS07765
gene id: 593117:TGAM_RS07765
uniprot id: C5A723
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

593117:TGAM RS05455
gene id: 593117:TGAM_RS05455
uniprot id: C5A5R5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

593117:TGAM RS10165
gene id: 593117:TGAM_RS10165
uniprot id: C5A285
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

593117:TGAM RS10055
gene id: 593117:TGAM_RS10055
uniprot id: C5A263
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

593117:TGAM RS08365
gene id: 593117:TGAM_RS08365
uniprot id: C5A7E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

593117:TGAM RS02170
gene id: 593117:TGAM_RS02170
uniprot id: C5A3W5
names: Similarity
messages: Belongs to the UPF0173 family.

593117:TGAM RS07205
gene id: 593117:TGAM_RS07205
uniprot id: C5A6R3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

593117:TGAM RS03265
gene id: 593117:TGAM_RS03265
uniprot id: C5A4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Membrane

593117:TGAM RS10030
gene id: 593117:TGAM_RS10030
uniprot id: C5A258
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

593117:TGAM RS02750
gene id: 593117:TGAM_RS02750
uniprot id: C5A478
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

593117:TGAM RS06680
gene id: 593117:TGAM_RS06680
uniprot id: C5A6F9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-65 and Arg-68) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

593117:TGAM RS00255
gene id: 593117:TGAM_RS00255
uniprot id: C5A2Q0
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS02395
gene id: 593117:TGAM_RS02395
uniprot id: C5A412
names: Similarity
messages: Belongs to the DtxR/MntR family.

593117:TGAM RS01415
gene id: 593117:TGAM_RS01415
uniprot id: C5A3H0
names: Similarity
messages: Belongs to the UPF0273 family.

593117:TGAM RS06620
gene id: 593117:TGAM_RS06620
uniprot id: C5A6E8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

593117:TGAM RS05950
gene id: 593117:TGAM_RS05950
uniprot id: C5A612
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

593117:TGAM RS04395
gene id: 593117:TGAM_RS04395
uniprot id: C5A551
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

593117:TGAM RS07215
gene id: 593117:TGAM_RS07215
uniprot id: C5A6R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

593117:TGAM RS09760
gene id: 593117:TGAM_RS09760
uniprot id: C5A210
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593117:TGAM RS05475
gene id: 593117:TGAM_RS05475
uniprot id: C5A5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS09095
gene id: 593117:TGAM_RS09095
uniprot id: C5A1N1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS01430
gene id: 593117:TGAM_RS01430
uniprot id: C5A3H3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

593117:TGAM RS04360
gene id: 593117:TGAM_RS04360
uniprot id: C5A545
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

593117:TGAM RS03945
gene id: 593117:TGAM_RS03945
uniprot id: C5A4W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

593117:TGAM RS06775
gene id: 593117:TGAM_RS06775
uniprot id: C5A6H7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

593117:TGAM RS04235
gene id: 593117:TGAM_RS04235
uniprot id: C5A520
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS09620
gene id: 593117:TGAM_RS09620
uniprot id: C5A1Y5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08525
gene id: 593117:TGAM_RS08525
uniprot id: C5A7H3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

593117:TGAM RS04805
gene id: 593117:TGAM_RS04805
uniprot id: C5A5D2
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03610
gene id: 593117:TGAM_RS03610
uniprot id: C5A4P4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS08515
gene id: 593117:TGAM_RS08515
uniprot id: C5A7H1
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

593117:TGAM RS08840
gene id: 593117:TGAM_RS08840
uniprot id: C5A1I3
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS04095
gene id: 593117:TGAM_RS04095
uniprot id: C5A4Z2
names: Similarity
messages: Belongs to the SfsA family.

593117:TGAM RS01690
gene id: 593117:TGAM_RS01690
uniprot id: C5A3M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS05470
gene id: 593117:TGAM_RS05470
uniprot id: C5A5R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS03880
gene id: 593117:TGAM_RS03880
uniprot id: C5A4U9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

593117:TGAM RS02550
gene id: 593117:TGAM_RS02550
uniprot id: C5A439
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

593117:TGAM RS00745
gene id: 593117:TGAM_RS00745
uniprot id: C5A336
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

593117:TGAM RS02075
gene id: 593117:TGAM_RS02075
uniprot id: C5A3U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

593117:TGAM RS10050
gene id: 593117:TGAM_RS10050
uniprot id: C5A262
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

593117:TGAM RS02045
gene id: 593117:TGAM_RS02045
uniprot id: C5A3U2
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

593117:TGAM RS09205
gene id: 593117:TGAM_RS09205
uniprot id: C5A1Q3
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS05130
gene id: 593117:TGAM_RS05130
uniprot id: C5A5J8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

593117:TGAM RS04625
gene id: 593117:TGAM_RS04625
uniprot id: C5A597
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

593117:TGAM RS10265
gene id: 593117:TGAM_RS10265
uniprot id: C5A2A6
names: Subcellular Location Annotation
messages: Nucleus

593117:TGAM RS03075
gene id: 593117:TGAM_RS03075
uniprot id: C5A4E4
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08550
gene id: 593117:TGAM_RS08550
uniprot id: C5A7H8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

593117:TGAM RS03100
gene id: 593117:TGAM_RS03100
uniprot id: C5A4E9
names: Similarity
messages: Belongs to the serpin family.

593117:TGAM RS07095
gene id: 593117:TGAM_RS07095
uniprot id: C5A6P1
names: Similarity
messages: Belongs to the UPF0179 family.

593117:TGAM RS07070
gene id: 593117:TGAM_RS07070
uniprot id: C5A6N6
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS03200
gene id: 593117:TGAM_RS03200
uniprot id: C5A4G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

593117:TGAM RS08435
gene id: 593117:TGAM_RS08435
uniprot id: C5A7F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

593117:TGAM RS08800
gene id: 593117:TGAM_RS08800
uniprot id: C5A1H5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

593117:TGAM RS10150
gene id: 593117:TGAM_RS10150
uniprot id: C5A282
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

593117:TGAM RS08950
gene id: 593117:TGAM_RS08950
uniprot id: C5A1K4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS09990
gene id: 593117:TGAM_RS09990
uniprot id: C5A249
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

593117:TGAM RS04275
gene id: 593117:TGAM_RS04275
uniprot id: C5A528
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

593117:TGAM RS01605
gene id: 593117:TGAM_RS01605
uniprot id: C5A3K7
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

593117:TGAM RS00810
gene id: 593117:TGAM_RS00810
uniprot id: C5A349
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

593117:TGAM RS02455
gene id: 593117:TGAM_RS02455
uniprot id: C5A422
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

593117:TGAM RS05020
gene id: 593117:TGAM_RS05020
uniprot id: C5A5H6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

593117:TGAM RS07365
gene id: 593117:TGAM_RS07365
uniprot id: C5A6U5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

593117:TGAM RS00735
gene id: 593117:TGAM_RS00735
uniprot id: C5A334
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593117:TGAM RS08755
gene id: 593117:TGAM_RS08755
uniprot id: C5A1G5
names: Similarity
messages: Belongs to the AOR/FOR family.

593117:TGAM RS01930
gene id: 593117:TGAM_RS01930
uniprot id: C5A3R9
names: Similarity
messages: Belongs to the UPF0282 family.

593117:TGAM RS00465
gene id: 593117:TGAM_RS00465
uniprot id: C5A2U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS01345
gene id: 593117:TGAM_RS01345
uniprot id: C5A3F6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS08910
gene id: 593117:TGAM_RS08910
uniprot id: C5A1J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

593117:TGAM RS05970
gene id: 593117:TGAM_RS05970
uniprot id: C5A616
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

593117:TGAM RS10755
gene id: 593117:TGAM_RS10755
uniprot id: C5A2W0
names: Similarity
messages: Belongs to the UPF0175 family.

593117:TGAM RS00025
gene id: 593117:TGAM_RS00025
uniprot id: C5A2K4
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS02155
gene id: 593117:TGAM_RS02155
uniprot id: C5A3W2
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

593117:TGAM RS03235
gene id: 593117:TGAM_RS03235
uniprot id: C5A4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

593117:TGAM RS01325
gene id: 593117:TGAM_RS01325
uniprot id: C5A3F2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS02780
gene id: 593117:TGAM_RS02780
uniprot id: C5A484
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

593117:TGAM RS10590
gene id: 593117:TGAM_RS10590
uniprot id: C5A2G8
names: Similarity
messages: Belongs to the UPF0175 family.

593117:TGAM RS05585
gene id: 593117:TGAM_RS05585
uniprot id: C5A5U1
names: Similarity
messages: Belongs to the HypE family.

593117:TGAM RS10040
gene id: 593117:TGAM_RS10040
uniprot id: C5A260
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10160
gene id: 593117:TGAM_RS10160
uniprot id: C5A284
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

593117:TGAM RS05490
gene id: 593117:TGAM_RS05490
uniprot id: C5A5S2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

593117:TGAM RS05330
gene id: 593117:TGAM_RS05330
uniprot id: C5A5P0
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

593117:TGAM RS06925
gene id: 593117:TGAM_RS06925
uniprot id: C5A6K8
names: Cofactor
messages: Binds 1 zinc ion per subunit.

593117:TGAM RS08265
gene id: 593117:TGAM_RS08265
uniprot id: C5A7C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

593117:TGAM RS00730
gene id: 593117:TGAM_RS00730
uniprot id: C5A333
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

593117:TGAM RS01350
gene id: 593117:TGAM_RS01350
uniprot id: C5A3F7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS05840
gene id: 593117:TGAM_RS05840
uniprot id: C5A5Y9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

593117:TGAM RS05350
gene id: 593117:TGAM_RS05350
uniprot id: C5A5P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

593117:TGAM RS05450
gene id: 593117:TGAM_RS05450
uniprot id: C5A5R4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

593117:TGAM RS00615
gene id: 593117:TGAM_RS00615
uniprot id: C5A313
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

593117:TGAM RS00710
gene id: 593117:TGAM_RS00710
uniprot id: C5A329
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

593117:TGAM RS10065
gene id: 593117:TGAM_RS10065
uniprot id: C5A265
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

593117:TGAM RS02945
gene id: 593117:TGAM_RS02945
uniprot id: C5A4B7
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

593117:TGAM RS09345
gene id: 593117:TGAM_RS09345
uniprot id: C5A1S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

593117:TGAM RS10130
gene id: 593117:TGAM_RS10130
uniprot id: C5A278
names: Similarity
messages: Belongs to the SUI1 family.

593117:TGAM RS05160
gene id: 593117:TGAM_RS05160
uniprot id: C5A5K4
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS00775
gene id: 593117:TGAM_RS00775
uniprot id: C5A342
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS01455
gene id: 593117:TGAM_RS01455
uniprot id: C5A3H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

593117:TGAM RS00215
gene id: 593117:TGAM_RS00215
uniprot id: C5A2P2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS01745
gene id: 593117:TGAM_RS01745
uniprot id: C5A3N4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

593117:TGAM RS10070
gene id: 593117:TGAM_RS10070
uniprot id: C5A266
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

593117:TGAM RS05155
gene id: 593117:TGAM_RS05155
uniprot id: C5A5K3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

593117:TGAM RS09000
gene id: 593117:TGAM_RS09000
uniprot id: C5A1L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

593117:TGAM RS05915
gene id: 593117:TGAM_RS05915
uniprot id: C5A605
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS05805
gene id: 593117:TGAM_RS05805
uniprot id: C5A5Y2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

593117:TGAM RS00690
gene id: 593117:TGAM_RS00690
uniprot id: C5A325
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

593117:TGAM RS09380
gene id: 593117:TGAM_RS09380
uniprot id: C5A1T6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

593117:TGAM RS07900
gene id: 593117:TGAM_RS07900
uniprot id: C5A750
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS00725
gene id: 593117:TGAM_RS00725
uniprot id: C5A332
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS10115
gene id: 593117:TGAM_RS10115
uniprot id: C5A275
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

593117:TGAM RS06290
gene id: 593117:TGAM_RS06290
uniprot id: C5A681
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS07270
gene id: 593117:TGAM_RS07270
uniprot id: C5A6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS09970
gene id: 593117:TGAM_RS09970
uniprot id: C5A246
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

593117:TGAM RS02425
gene id: 593117:TGAM_RS02425
uniprot id: C5A418
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS04950
gene id: 593117:TGAM_RS04950
uniprot id: C5A5G2
names: Similarity
messages: Belongs to the AAA ATPase family.

593117:TGAM RS08785
gene id: 593117:TGAM_RS08785
uniprot id: C5A1H2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

593117:TGAM RS10085
gene id: 593117:TGAM_RS10085
uniprot id: C5A269
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

593117:TGAM RS01815
gene id: 593117:TGAM_RS01815
uniprot id: C5A3P6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS07130
gene id: 593117:TGAM_RS07130
uniprot id: C5A6P8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

593117:TGAM RS02865
gene id: 593117:TGAM_RS02865
uniprot id: C5A4A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS07825
gene id: 593117:TGAM_RS07825
uniprot id: C5A735
names: Similarity
messages: Belongs to the RuvB family.

593117:TGAM RS06420
gene id: 593117:TGAM_RS06420
uniprot id: C5A6A8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

593117:TGAM RS00250
gene id: 593117:TGAM_RS00250
uniprot id: C5A2P9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS06365
gene id: 593117:TGAM_RS06365
uniprot id: C5A696
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

593117:TGAM RS04920
gene id: 593117:TGAM_RS04920
uniprot id: C5A5F6
names: Similarity
messages: Belongs to the AAA ATPase family.

593117:TGAM RS10375
gene id: 593117:TGAM_RS10375
uniprot id: C5A2C7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS01340
gene id: 593117:TGAM_RS01340
uniprot id: C5A3F5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS00455
gene id: 593117:TGAM_RS00455
uniprot id: C5A2U0
names: Similarity
messages: Belongs to the UPF0147 family.

593117:TGAM RS02565
gene id: 593117:TGAM_RS02565
uniprot id: C5A442
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

593117:TGAM RS07580
gene id: 593117:TGAM_RS07580
uniprot id: C5A6Y8
names: Function
messages: Probably involved in the biogenesis of the ribosome.

593117:TGAM RS01240
gene id: 593117:TGAM_RS01240
uniprot id: C5A3D5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS01615
gene id: 593117:TGAM_RS01615
uniprot id: C5A3K9
names: Similarity
messages: Belongs to the class-I fumarase family.

593117:TGAM RS03160
gene id: 593117:TGAM_RS03160
uniprot id: C5A4G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

593117:TGAM RS00305
gene id: 593117:TGAM_RS00305
uniprot id: C5A2R0
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS00910
gene id: 593117:TGAM_RS00910
uniprot id: C5A369
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

593117:TGAM RS06700
gene id: 593117:TGAM_RS06700
uniprot id: C5A6G2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS03175
gene id: 593117:TGAM_RS03175
uniprot id: C5A4G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

593117:TGAM RS00590
gene id: 593117:TGAM_RS00590
uniprot id: C5A308
names: Similarity
messages: Belongs to the UPF0111 family.

593117:TGAM RS09745
gene id: 593117:TGAM_RS09745
uniprot id: C5A207
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

593117:TGAM RS04175
gene id: 593117:TGAM_RS04175
uniprot id: C5A508
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP-dependent glucokinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the ADP-dependent phosphorylation of D-glucose to D-glucose 6-phosphate and glucosamine to glucosamine 6-phosphate.
messages: Cytoplasm

593117:TGAM RS07530
gene id: 593117:TGAM_RS07530
uniprot id: C5A6X8
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08955
gene id: 593117:TGAM_RS08955
uniprot id: C5A1K5
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

593117:TGAM RS01580
gene id: 593117:TGAM_RS01580
uniprot id: C5A3K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

593117:TGAM RS07050
gene id: 593117:TGAM_RS07050
uniprot id: C5A6N2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

593117:TGAM RS08360
gene id: 593117:TGAM_RS08360
uniprot id: C5A7E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

593117:TGAM RS06970
gene id: 593117:TGAM_RS06970
uniprot id: C5A6L7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

593117:TGAM RS05430
gene id: 593117:TGAM_RS05430
uniprot id: C5A5R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS02485
gene id: 593117:TGAM_RS02485
uniprot id: C5A428
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

593117:TGAM RS09555
gene id: 593117:TGAM_RS09555
uniprot id: C5A1X2
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

593117:TGAM RS05670
gene id: 593117:TGAM_RS05670
uniprot id: C5A5V8
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS06245
gene id: 593117:TGAM_RS06245
uniprot id: C5A672
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS09300
gene id: 593117:TGAM_RS09300
uniprot id: C5A1S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

593117:TGAM RS00940
gene id: 593117:TGAM_RS00940
uniprot id: C5A376
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

593117:TGAM RS09945
gene id: 593117:TGAM_RS09945
uniprot id: C5A242
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

593117:TGAM RS09730
gene id: 593117:TGAM_RS09730
uniprot id: C5A204
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

593117:TGAM RS08705
gene id: 593117:TGAM_RS08705
uniprot id: C5A7L2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

593117:TGAM RS01175
gene id: 593117:TGAM_RS01175
uniprot id: C5A3C2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

593117:TGAM RS04375
gene id: 593117:TGAM_RS04375
uniprot id: C5A547
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS09995
gene id: 593117:TGAM_RS09995
uniprot id: C5A250
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS07695
gene id: 593117:TGAM_RS07695
uniprot id: C5A710
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

593117:TGAM RS00235
gene id: 593117:TGAM_RS00235
uniprot id: C5A2P6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS08075
gene id: 593117:TGAM_RS08075
uniprot id: C5A785
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS07220
gene id: 593117:TGAM_RS07220
uniprot id: C5A6R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

593117:TGAM RS09375
gene id: 593117:TGAM_RS09375
uniprot id: C5A1T5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS07115
gene id: 593117:TGAM_RS07115
uniprot id: C5A6P5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS06380
gene id: 593117:TGAM_RS06380
uniprot id: C5A699
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

593117:TGAM RS05835
gene id: 593117:TGAM_RS05835
uniprot id: C5A5Y8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

593117:TGAM RS08370
gene id: 593117:TGAM_RS08370
uniprot id: C5A7E3
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS10020
gene id: 593117:TGAM_RS10020
uniprot id: C5A255
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

593117:TGAM RS06745
gene id: 593117:TGAM_RS06745
uniprot id: C5A6H1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

593117:TGAM RS01435
gene id: 593117:TGAM_RS01435
uniprot id: C5A3H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

593117:TGAM RS09335
gene id: 593117:TGAM_RS09335
uniprot id: C5A1S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

593117:TGAM RS05230
gene id: 593117:TGAM_RS05230
uniprot id: C5A5L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

593117:TGAM RS08675
gene id: 593117:TGAM_RS08675
uniprot id: C5A7K6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

593117:TGAM RS10345
gene id: 593117:TGAM_RS10345
uniprot id: C5A2C1
names: Similarity
messages: Belongs to the SDO1/SBDS family.

593117:TGAM RS02555
gene id: 593117:TGAM_RS02555
uniprot id: C5A440
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

593117:TGAM RS00750
gene id: 593117:TGAM_RS00750
uniprot id: C5A337
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

593117:TGAM RS00990
gene id: 593117:TGAM_RS00990
uniprot id: C5A386
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03715
gene id: 593117:TGAM_RS03715
uniprot id: C5A4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

593117:TGAM RS09955
gene id: 593117:TGAM_RS09955
uniprot id: C5A244
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593117:TGAM RS05150
gene id: 593117:TGAM_RS05150
uniprot id: C5A5K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

593117:TGAM RS01315
gene id: 593117:TGAM_RS01315
uniprot id: C5A3F0
names: Similarity
messages: Belongs to the HypE family.

593117:TGAM RS05845
gene id: 593117:TGAM_RS05845
uniprot id: C5A5Z0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

593117:TGAM RS08065
gene id: 593117:TGAM_RS08065
uniprot id: C5A783
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

593117:TGAM RS07140
gene id: 593117:TGAM_RS07140
uniprot id: C5A6Q0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

593117:TGAM RS07265
gene id: 593117:TGAM_RS07265
uniprot id: C5A6S5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

593117:TGAM RS03675
gene id: 593117:TGAM_RS03675
uniprot id: C5A4Q7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

593117:TGAM RS04185
gene id: 593117:TGAM_RS04185
uniprot id: C5A510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593117:TGAM RS10140
gene id: 593117:TGAM_RS10140
uniprot id: C5A280
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS09725
gene id: 593117:TGAM_RS09725
uniprot id: C5A203
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS07125
gene id: 593117:TGAM_RS07125
uniprot id: C5A6P7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

593117:TGAM RS02685
gene id: 593117:TGAM_RS02685
uniprot id: C5A466
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

593117:TGAM RS00260
gene id: 593117:TGAM_RS00260
uniprot id: C5A2Q1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS07600
gene id: 593117:TGAM_RS07600
uniprot id: C5A6Z1
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

593117:TGAM RS08925
gene id: 593117:TGAM_RS08925
uniprot id: C5A1K0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

593117:TGAM RS06315
gene id: 593117:TGAM_RS06315
uniprot id: C5A686
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

593117:TGAM RS04320
gene id: 593117:TGAM_RS04320
uniprot id: C5A537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS10580
gene id: 593117:TGAM_RS10580
uniprot id: C5A2G6
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08670
gene id: 593117:TGAM_RS08670
uniprot id: C5A7K5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08650
gene id: 593117:TGAM_RS08650
uniprot id: C5A7K1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

593117:TGAM RS05460
gene id: 593117:TGAM_RS05460
uniprot id: C5A5R6
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

593117:TGAM RS06410
gene id: 593117:TGAM_RS06410
uniprot id: C5A6A5
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

593117:TGAM RS00370
gene id: 593117:TGAM_RS00370
uniprot id: C5A2S3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS01720
gene id: 593117:TGAM_RS01720
uniprot id: C5A3M9
names: Similarity
messages: Belongs to the UPF0216 family.

593117:TGAM RS08740
gene id: 593117:TGAM_RS08740
uniprot id: C5A1G2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

593117:TGAM RS03155
gene id: 593117:TGAM_RS03155
uniprot id: C5A4G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

593117:TGAM RS08970
gene id: 593117:TGAM_RS08970
uniprot id: C5A1K9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

593117:TGAM RS09610
gene id: 593117:TGAM_RS09610
uniprot id: C5A1Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

593117:TGAM RS02595
gene id: 593117:TGAM_RS02595
uniprot id: C5A448
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

593117:TGAM RS04795
gene id: 593117:TGAM_RS04795
uniprot id: C5A5D0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

593117:TGAM RS10905
gene id: 593117:TGAM_RS10905
uniprot id: C5A2Z1
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

593117:TGAM RS10635
gene id: 593117:TGAM_RS10635
uniprot id: C5A2H8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

593117:TGAM RS02980
gene id: 593117:TGAM_RS02980
uniprot id: C5A4C4
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS06945
gene id: 593117:TGAM_RS06945
uniprot id: C5A6L2
names: Similarity
messages: Belongs to the UPF0127 family.

593117:TGAM RS10535
gene id: 593117:TGAM_RS10535
uniprot id: C5A2F7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

593117:TGAM RS09695
gene id: 593117:TGAM_RS09695
uniprot id: C5A1Z6
names: Similarity
messages: Belongs to the AOR/FOR family.

593117:TGAM RS10260
gene id: 593117:TGAM_RS10260
uniprot id: C5A2A5
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

593117:TGAM RS01545
gene id: 593117:TGAM_RS01545
uniprot id: C5A3J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

593117:TGAM RS07815
gene id: 593117:TGAM_RS07815
uniprot id: C5A733
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS05625
gene id: 593117:TGAM_RS05625
uniprot id: C5A5U9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS04660
gene id: 593117:TGAM_RS04660
uniprot id: C5A5A4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS00450
gene id: 593117:TGAM_RS00450
uniprot id: C5A2T9
names: Subunit
messages: Homotetramer.

593117:TGAM RS07540
gene id: 593117:TGAM_RS07540
uniprot id: C5A6Y0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

593117:TGAM RS10850
gene id: 593117:TGAM_RS10850
uniprot id: C5A2Y0
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS01645
gene id: 593117:TGAM_RS01645
uniprot id: C5A3L5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

593117:TGAM RS04300
gene id: 593117:TGAM_RS04300
uniprot id: C5A533
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

593117:TGAM RS05265
gene id: 593117:TGAM_RS05265
uniprot id: C5A5M6
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS01840
gene id: 593117:TGAM_RS01840
uniprot id: C5A3Q1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

593117:TGAM RS08860
gene id: 593117:TGAM_RS08860
uniprot id: C5A1I7
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

593117:TGAM RS01465
gene id: 593117:TGAM_RS01465
uniprot id: C5A3I0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

593117:TGAM RS08170
gene id: 593117:TGAM_RS08170
uniprot id: C5A7A4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

593117:TGAM RS04855
gene id: 593117:TGAM_RS04855
uniprot id: C5A5E2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

593117:TGAM RS03260
gene id: 593117:TGAM_RS03260
uniprot id: C5A4I2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

593117:TGAM RS08080
gene id: 593117:TGAM_RS08080
uniprot id: C5A786
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

593117:TGAM RS07360
gene id: 593117:TGAM_RS07360
uniprot id: C5A6U4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

593117:TGAM RS10170
gene id: 593117:TGAM_RS10170
uniprot id: C5A286
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

593117:TGAM RS06370
gene id: 593117:TGAM_RS06370
uniprot id: C5A697
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

593117:TGAM RS05115
gene id: 593117:TGAM_RS05115
uniprot id: C5A5J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

593117:TGAM RS09830
gene id: 593117:TGAM_RS09830
uniprot id: C5A223
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

593117:TGAM RS10250
gene id: 593117:TGAM_RS10250
uniprot id: C5A2A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

593117:TGAM RS08320
gene id: 593117:TGAM_RS08320
uniprot id: C5A7D3
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS01080
gene id: 593117:TGAM_RS01080
uniprot id: C5A3A4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

593117:TGAM RS09755
gene id: 593117:TGAM_RS09755
uniprot id: C5A209
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

593117:TGAM RS08600
gene id: 593117:TGAM_RS08600
uniprot id: C5A7J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

593117:TGAM RS03515
gene id: 593117:TGAM_RS03515
uniprot id: C5A4M2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

593117:TGAM RS10080
gene id: 593117:TGAM_RS10080
uniprot id: C5A268
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

593117:TGAM RS03855
gene id: 593117:TGAM_RS03855
uniprot id: C5A4U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

593117:TGAM RS04025
gene id: 593117:TGAM_RS04025
uniprot id: C5A4Y0
names: Similarity
messages: Belongs to the UPF0047 family.

593117:TGAM RS09845
gene id: 593117:TGAM_RS09845
uniprot id: C5A226
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

593117:TGAM RS05190
gene id: 593117:TGAM_RS05190
uniprot id: C5A5L0
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

593117:TGAM RS00670
gene id: 593117:TGAM_RS00670
uniprot id: C5A321
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

593117:TGAM RS01040
gene id: 593117:TGAM_RS01040
uniprot id: C5A396
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

593117:TGAM RS10340
gene id: 593117:TGAM_RS10340
uniprot id: C5A2C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

593117:TGAM RS08180
gene id: 593117:TGAM_RS08180
uniprot id: C5A7A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

593117:TGAM RS09305
gene id: 593117:TGAM_RS09305
uniprot id: C5A1S1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

593117:TGAM RS02460
gene id: 593117:TGAM_RS02460
uniprot id: C5A423
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

593117:TGAM RS03070
gene id: 593117:TGAM_RS03070
uniprot id: C5A4E3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

593117:TGAM RS06235
gene id: 593117:TGAM_RS06235
uniprot id: C5A670
names: Subcellular Location Annotation
messages: Cell membrane

593117:TGAM RS06060
gene id: 593117:TGAM_RS06060
uniprot id: C5A635
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

593117:TGAM RS05535
gene id: 593117:TGAM_RS05535
uniprot id: C5A5T1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

593117:TGAM RS06790
gene id: 593117:TGAM_RS06790
uniprot id: C5A6I1
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

593117:TGAM RS01620
gene id: 593117:TGAM_RS01620
uniprot id: C5A3L0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

593117:TGAM RS05315
gene id: 593117:TGAM_RS05315
uniprot id: C5A5N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

593117:TGAM RS09780
gene id: 593117:TGAM_RS09780
uniprot id: C5A213
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

593117:TGAM RS05995
gene id: 593117:TGAM_RS05995
uniprot id: C5A621
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

593117:TGAM RS04135
gene id: 593117:TGAM_RS04135
uniprot id: C5A500
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

593117:TGAM RS00475
gene id: 593117:TGAM_RS00475
uniprot id: C5A2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

593117:TGAM RS03820
gene id: 593117:TGAM_RS03820
uniprot id: C5A4T7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

593117:TGAM RS09450
gene id: 593117:TGAM_RS09450
uniprot id: C5A1V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS05320
gene id: 593117:TGAM_RS05320
uniprot id: C5A5N8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

593117:TGAM RS10045
gene id: 593117:TGAM_RS10045
uniprot id: C5A261
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

593117:TGAM RS08870
gene id: 593117:TGAM_RS08870
uniprot id: C5A1I9
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08590
gene id: 593117:TGAM_RS08590
uniprot id: C5A7I8
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08990
gene id: 593117:TGAM_RS08990
uniprot id: C5A1L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

593117:TGAM RS08350
gene id: 593117:TGAM_RS08350
uniprot id: C5A7D9
names: Similarity
messages: Belongs to the peptidase S49 family.

593117:TGAM RS04910
gene id: 593117:TGAM_RS04910
uniprot id: C5A5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

593117:TGAM RS09975
gene id: 593117:TGAM_RS09975
uniprot id: C5A247
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

593117:TGAM RS02715
gene id: 593117:TGAM_RS02715
uniprot id: C5A472
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

593117:TGAM RS02495
gene id: 593117:TGAM_RS02495
uniprot id: C5A430
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

593117:TGAM RS08620
gene id: 593117:TGAM_RS08620
uniprot id: C5A7J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

593117:TGAM RS07605
gene id: 593117:TGAM_RS07605
uniprot id: C5A6Z2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

593117:TGAM RS03780
gene id: 593117:TGAM_RS03780
uniprot id: C5A4S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

593117:TGAM RS09700
gene id: 593117:TGAM_RS09700
uniprot id: C5A1Z7
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS04620
gene id: 593117:TGAM_RS04620
uniprot id: C5A596
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

593117:TGAM RS05605
gene id: 593117:TGAM_RS05605
uniprot id: C5A5U5
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS06920
gene id: 593117:TGAM_RS06920
uniprot id: C5A6K7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

593117:TGAM RS08455
gene id: 593117:TGAM_RS08455
uniprot id: C5A7F9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS08475
gene id: 593117:TGAM_RS08475
uniprot id: C5A7G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

593117:TGAM RS01290
gene id: 593117:TGAM_RS01290
uniprot id: C5A3E5
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

593117:TGAM RS09485
gene id: 593117:TGAM_RS09485
uniprot id: C5A1V8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

593117:TGAM RS02410
gene id: 593117:TGAM_RS02410
uniprot id: C5A415
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

593117:TGAM RS00610
gene id: 593117:TGAM_RS00610
uniprot id: C5A312
names: Similarity
messages: Belongs to the AOR/FOR family.

593117:TGAM RS02365
gene id: 593117:TGAM_RS02365
uniprot id: C5A406
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

593117:TGAM RS10765
gene id: 593117:TGAM_RS10765
uniprot id: C5A2W3
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

593117:TGAM RS07370
gene id: 593117:TGAM_RS07370
uniprot id: C5A6U6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

593117:TGAM RS09320
gene id: 593117:TGAM_RS09320
uniprot id: C5A1S4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS08485
gene id: 593117:TGAM_RS08485
uniprot id: C5A7G5
names: Similarity
messages: Belongs to the arginase family.

593117:TGAM RS09160
gene id: 593117:TGAM_RS09160
uniprot id: C5A1P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

593117:TGAM RS08735
gene id: 593117:TGAM_RS08735
uniprot id: C5A7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

593117:TGAM RS09115
gene id: 593117:TGAM_RS09115
uniprot id: C5A1N5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

593117:TGAM RS06935
gene id: 593117:TGAM_RS06935
uniprot id: C5A6L0
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS03900
gene id: 593117:TGAM_RS03900
uniprot id: C5A4V3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

593117:TGAM RS01630
gene id: 593117:TGAM_RS01630
uniprot id: C5A3L2
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

593117:TGAM RS04420
gene id: 593117:TGAM_RS04420
uniprot id: C5A556
names: Similarity
messages: Belongs to the UPF0201 family.

593117:TGAM RS07575
gene id: 593117:TGAM_RS07575
uniprot id: C5A6Y7
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

593117:TGAM RS10440
gene id: 593117:TGAM_RS10440
uniprot id: C5A2D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

593117:TGAM RS08505
gene id: 593117:TGAM_RS08505
uniprot id: C5A7G9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

593117:TGAM RS00210
gene id: 593117:TGAM_RS00210
uniprot id: C5A2P1
names: Subcellular Location Annotation
messages: Membrane

593117:TGAM RS08165
gene id: 593117:TGAM_RS08165
uniprot id: C5A7A3
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

593117:TGAM RS03240
gene id: 593117:TGAM_RS03240
uniprot id: C5A4H8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

593117:TGAM RS01905
gene id: 593117:TGAM_RS01905
uniprot id: C5A3R4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

593117:TGAM RS10800
gene id: 593117:TGAM_RS10800
uniprot id: C5A2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

593117:TGAM RS07780
gene id: 593117:TGAM_RS07780
uniprot id: C5A726
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

593117:TGAM RS08780
gene id: 593117:TGAM_RS08780
uniprot id: C5A1H1
names: Similarity
messages: Belongs to the snRNP Sm proteins family.