580331:THIT RS02655
gene id: 580331:THIT_RS02655
uniprot id: D3T7A4
names: Similarity
messages: Belongs to the carbamate kinase family.

580331:THIT RS03825
gene id: 580331:THIT_RS03825
uniprot id: D3T7W3
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

580331:THIT RS04855
gene id: 580331:THIT_RS04855
uniprot id: D3T8F8
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

580331:THIT RS00610
gene id: 580331:THIT_RS00610
uniprot id: D3T5E0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

580331:THIT RS05270
gene id: 580331:THIT_RS05270
uniprot id: D3T8P0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10845
gene id: 580331:THIT_RS10845
uniprot id: D3T5K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

580331:THIT RS09800
gene id: 580331:THIT_RS09800
uniprot id: D3T4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

580331:THIT RS01880
gene id: 580331:THIT_RS01880
uniprot id: D3T6S4
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

580331:THIT RS01475
gene id: 580331:THIT_RS01475
uniprot id: D3T6J5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

580331:THIT RS04465
gene id: 580331:THIT_RS04465
uniprot id: D3T887
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

580331:THIT RS08805
gene id: 580331:THIT_RS08805
uniprot id: D3T458
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

580331:THIT RS00820
gene id: 580331:THIT_RS00820
uniprot id: D3T5V3
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS04630
gene id: 580331:THIT_RS04630
uniprot id: D3T8B8
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

580331:THIT RS01195
gene id: 580331:THIT_RS01195
uniprot id: D3T628
names: Similarity
messages: Belongs to the UPF0236 family.

580331:THIT RS00095
gene id: 580331:THIT_RS00095
uniprot id: D3T548
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

580331:THIT RS04170
gene id: 580331:THIT_RS04170
uniprot id: D3T829
names: Similarity
messages: Belongs to the UPF0758 family.

580331:THIT RS09810
gene id: 580331:THIT_RS09810
uniprot id: D3T4N4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

580331:THIT RS04325
gene id: 580331:THIT_RS04325
uniprot id: D3T860
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

580331:THIT RS10100
gene id: 580331:THIT_RS10100
uniprot id: D3T4V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS00065
gene id: 580331:THIT_RS00065
uniprot id: D3T542
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS08885
gene id: 580331:THIT_RS08885
uniprot id: D3T474
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

580331:THIT RS04645
gene id: 580331:THIT_RS04645
uniprot id: D3T8C1
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

580331:THIT RS00050
gene id: 580331:THIT_RS00050
uniprot id: D3T539
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

580331:THIT RS07510
gene id: 580331:THIT_RS07510
uniprot id: D3T3G2
names: Similarity
messages: Belongs to the peptidase M18 family.

580331:THIT RS09145
gene id: 580331:THIT_RS09145
uniprot id: D3T4C2
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS02225
gene id: 580331:THIT_RS02225
uniprot id: D3T722
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

580331:THIT RS05815
gene id: 580331:THIT_RS05815
uniprot id: D3T8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

580331:THIT RS00070
gene id: 580331:THIT_RS00070
uniprot id: D3T543
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.

580331:THIT RS00695
gene id: 580331:THIT_RS00695
uniprot id: D3T5F7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

580331:THIT RS03985
gene id: 580331:THIT_RS03985
uniprot id: D3T7Z3
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.

580331:THIT RS06375
gene id: 580331:THIT_RS06375
uniprot id: D3T2U0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

580331:THIT RS02840
gene id: 580331:THIT_RS02840
uniprot id: D3T7E1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

580331:THIT RS03170
gene id: 580331:THIT_RS03170
uniprot id: D3T7J9
names: Similarity
messages: Belongs to the EamA transporter family.

580331:THIT RS03155
gene id: 580331:THIT_RS03155
uniprot id: D3T7J6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

580331:THIT RS05165
gene id: 580331:THIT_RS05165
uniprot id: D3T8L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS00550
gene id: 580331:THIT_RS00550
uniprot id: D3T5C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

580331:THIT RS03175
gene id: 580331:THIT_RS03175
uniprot id: D3T7K0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS01875
gene id: 580331:THIT_RS01875
uniprot id: D3T6S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

580331:THIT RS00825
gene id: 580331:THIT_RS00825
uniprot id: D3T5V4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS04165
gene id: 580331:THIT_RS04165
uniprot id: D3T828
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

580331:THIT RS05930
gene id: 580331:THIT_RS05930
uniprot id: D3T922
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

580331:THIT RS10280
gene id: 580331:THIT_RS10280
uniprot id: D3T4Y6
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

580331:THIT RS09900
gene id: 580331:THIT_RS09900
uniprot id: D3T4Q2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

580331:THIT RS11270
gene id: 580331:THIT_RS11270
uniprot id: D3T671
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.

580331:THIT RS03590
gene id: 580331:THIT_RS03590
uniprot id: D3T7S4
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS05200
gene id: 580331:THIT_RS05200
uniprot id: D3T8M6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

580331:THIT RS11510
gene id: 580331:THIT_RS11510
uniprot id: D3T6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

580331:THIT RS02040
gene id: 580331:THIT_RS02040
uniprot id: D3T6Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05540
gene id: 580331:THIT_RS05540
uniprot id: D3T8U5
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.

580331:THIT RS06725
gene id: 580331:THIT_RS06725
uniprot id: D3T307
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

580331:THIT RS00420
gene id: 580331:THIT_RS00420
uniprot id: D3T5A2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

580331:THIT RS07200
gene id: 580331:THIT_RS07200
uniprot id: D3T3A1
names: Similarity
messages: Belongs to the RutC family.

580331:THIT RS04650
gene id: 580331:THIT_RS04650
uniprot id: D3T8C2
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

580331:THIT RS02220
gene id: 580331:THIT_RS02220
uniprot id: D3T721
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

580331:THIT RS04910
gene id: 580331:THIT_RS04910
uniprot id: D3T8G9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS01525
gene id: 580331:THIT_RS01525
uniprot id: D3T6K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

580331:THIT RS06240
gene id: 580331:THIT_RS06240
uniprot id: D3T2R2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

580331:THIT RS01760
gene id: 580331:THIT_RS01760
uniprot id: D3T6Q0
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

580331:THIT RS05840
gene id: 580331:THIT_RS05840
uniprot id: D3T904
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

580331:THIT RS07125
gene id: 580331:THIT_RS07125
uniprot id: D3T386
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

580331:THIT RS09820
gene id: 580331:THIT_RS09820
uniprot id: D3T4N6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

580331:THIT RS05360
gene id: 580331:THIT_RS05360
uniprot id: D3T8Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

580331:THIT RS08600
gene id: 580331:THIT_RS08600
uniprot id: D3T417
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

580331:THIT RS00465
gene id: 580331:THIT_RS00465
uniprot id: D3T5B1
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

580331:THIT RS02695
gene id: 580331:THIT_RS02695
uniprot id: D3T7B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

580331:THIT RS05420
gene id: 580331:THIT_RS05420
uniprot id: D3T8S0
names: Similarity
messages: Belongs to the asp23 family.

580331:THIT RS01740
gene id: 580331:THIT_RS01740
uniprot id: D3T6P6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

580331:THIT RS06305
gene id: 580331:THIT_RS06305
uniprot id: D3T2S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

580331:THIT RS07115
gene id: 580331:THIT_RS07115
uniprot id: D3T384
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

580331:THIT RS05970
gene id: 580331:THIT_RS05970
uniprot id: D3T2L0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

580331:THIT RS00845
gene id: 580331:THIT_RS00845
uniprot id: D3T5V8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS02245
gene id: 580331:THIT_RS02245
uniprot id: D3T726
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

580331:THIT RS04815
gene id: 580331:THIT_RS04815
uniprot id: D3T8F0
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

580331:THIT RS02940
gene id: 580331:THIT_RS02940
uniprot id: D3T7G1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

580331:THIT RS00380
gene id: 580331:THIT_RS00380
uniprot id: D3T597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

580331:THIT RS01270
gene id: 580331:THIT_RS01270
uniprot id: D3T643
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

580331:THIT RS01395
gene id: 580331:THIT_RS01395
uniprot id: D3T6H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

580331:THIT RS05665
gene id: 580331:THIT_RS05665
uniprot id: D3T8X1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

580331:THIT RS10295
gene id: 580331:THIT_RS10295
uniprot id: D3T4Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS10225
gene id: 580331:THIT_RS10225
uniprot id: D3T4X5
names: Similarity
messages: Belongs to the SfsA family.

580331:THIT RS10025
gene id: 580331:THIT_RS10025
uniprot id: D3T4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

580331:THIT RS02675
gene id: 580331:THIT_RS02675
uniprot id: D3T7A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

580331:THIT RS01300
gene id: 580331:THIT_RS01300
uniprot id: D3T648
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

580331:THIT RS04665
gene id: 580331:THIT_RS04665
uniprot id: D3T8C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

580331:THIT RS06685
gene id: 580331:THIT_RS06685
uniprot id: D3T300
names: Similarity
messages: Belongs to the HypE family.

580331:THIT RS10760
gene id: 580331:THIT_RS10760
uniprot id: D3T5J2
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06400
gene id: 580331:THIT_RS06400
uniprot id: D3T2U5
names: Function
names: Similarity
messages: Belongs to the FapR family.
messages: Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.

580331:THIT RS09875
gene id: 580331:THIT_RS09875
uniprot id: D3T4P7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

580331:THIT RS04990
gene id: 580331:THIT_RS04990
uniprot id: D3T8I4
names: Similarity
messages: Belongs to the IMPACT family.

580331:THIT RS07395
gene id: 580331:THIT_RS07395
uniprot id: D3T3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

580331:THIT RS04435
gene id: 580331:THIT_RS04435
uniprot id: D3T881
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.
messages: Belongs to the peptidase A25 family.
messages: Homotetramer.
messages: Initiates the rapid degradation of small, acid-soluble proteins during spore germination.

580331:THIT RS07310
gene id: 580331:THIT_RS07310
uniprot id: D3T3C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

580331:THIT RS05085
gene id: 580331:THIT_RS05085
uniprot id: D3T8K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

580331:THIT RS11045
gene id: 580331:THIT_RS11045
uniprot id: D3T5P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS09270
gene id: 580331:THIT_RS09270
uniprot id: D3T4E6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

580331:THIT RS09825
gene id: 580331:THIT_RS09825
uniprot id: D3T4N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

580331:THIT RS01100
gene id: 580331:THIT_RS01100
uniprot id: D3T609
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

580331:THIT RS02030
gene id: 580331:THIT_RS02030
uniprot id: D3T6Y3
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS09940
gene id: 580331:THIT_RS09940
uniprot id: D3T4S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

580331:THIT RS04460
gene id: 580331:THIT_RS04460
uniprot id: D3T886
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

580331:THIT RS04100
gene id: 580331:THIT_RS04100
uniprot id: D3T815
names: Similarity
messages: Belongs to the transglycosylase Slt family.

580331:THIT RS01860
gene id: 580331:THIT_RS01860
uniprot id: D3T6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

580331:THIT RS07685
gene id: 580331:THIT_RS07685
uniprot id: D3T3J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

580331:THIT RS02215
gene id: 580331:THIT_RS02215
uniprot id: D3T720
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

580331:THIT RS00675
gene id: 580331:THIT_RS00675
uniprot id: D3T5F4
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS00585
gene id: 580331:THIT_RS00585
uniprot id: D3T5D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

580331:THIT RS11665
gene id: 580331:THIT_RS11665
uniprot id: D3T6E7
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

580331:THIT RS07710
gene id: 580331:THIT_RS07710
uniprot id: D3T3J4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

580331:THIT RS08565
gene id: 580331:THIT_RS08565
uniprot id: D3T410
names: Similarity
messages: Belongs to the glycosyl hydrolase.

580331:THIT RS11215
gene id: 580331:THIT_RS11215
uniprot id: D3T660
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

580331:THIT RS03055
gene id: 580331:THIT_RS03055
uniprot id: D3T7H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

580331:THIT RS09765
gene id: 580331:THIT_RS09765
uniprot id: D3T4M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

580331:THIT RS11650
gene id: 580331:THIT_RS11650
uniprot id: D3T6E4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

580331:THIT RS06695
gene id: 580331:THIT_RS06695
uniprot id: D3T302
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

580331:THIT RS10765
gene id: 580331:THIT_RS10765
uniprot id: D3T5J3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

580331:THIT RS05735
gene id: 580331:THIT_RS05735
uniprot id: D3T8Y3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS02465
gene id: 580331:THIT_RS02465
uniprot id: D3T767
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

580331:THIT RS00080
gene id: 580331:THIT_RS00080
uniprot id: D3T545
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

580331:THIT RS02125
gene id: 580331:THIT_RS02125
uniprot id: D3T702
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS03575
gene id: 580331:THIT_RS03575
uniprot id: D3T7S1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

580331:THIT RS09065
gene id: 580331:THIT_RS09065
uniprot id: D3T4A7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

580331:THIT RS00850
gene id: 580331:THIT_RS00850
uniprot id: D3T5V9
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

580331:THIT RS02380
gene id: 580331:THIT_RS02380
uniprot id: D3T750
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

580331:THIT RS02915
gene id: 580331:THIT_RS02915
uniprot id: D3T7F6
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

580331:THIT RS10000
gene id: 580331:THIT_RS10000
uniprot id: D3T4R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

580331:THIT RS07220
gene id: 580331:THIT_RS07220
uniprot id: D3T3A5
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

580331:THIT RS08790
gene id: 580331:THIT_RS08790
uniprot id: D3T455
names: Cofactor
names: Similarity
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.

580331:THIT RS09325
gene id: 580331:THIT_RS09325
uniprot id: D3T4F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

580331:THIT RS10865
gene id: 580331:THIT_RS10865
uniprot id: D3T5L1
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

580331:THIT RS07810
gene id: 580331:THIT_RS07810
uniprot id: D3T3K9
names: Similarity
messages: Belongs to the acylphosphatase family.

580331:THIT RS00445
gene id: 580331:THIT_RS00445
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS08440
gene id: 580331:THIT_RS08440
uniprot id: D3T3Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS11095
gene id: 580331:THIT_RS11095
uniprot id: D3T5Q7
names: Similarity
messages: Belongs to the SleB family.

580331:THIT RS05865
gene id: 580331:THIT_RS05865
uniprot id: D3T909
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

580331:THIT RS09530
gene id: 580331:THIT_RS09530
uniprot id: D3T4J2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS06270
gene id: 580331:THIT_RS06270
uniprot id: D3T2R8
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

580331:THIT RS07590
gene id: 580331:THIT_RS07590
uniprot id: D3T3H7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS06540
gene id: 580331:THIT_RS06540
uniprot id: D3T2X3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

580331:THIT RS05295
gene id: 580331:THIT_RS05295
uniprot id: D3T8P5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

580331:THIT RS07575
gene id: 580331:THIT_RS07575
uniprot id: D3T3H4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

580331:THIT RS06120
gene id: 580331:THIT_RS06120
uniprot id: D3T2P0
names: Similarity
messages: Belongs to the FlgD family.

580331:THIT RS02925
gene id: 580331:THIT_RS02925
uniprot id: D3T7F8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

580331:THIT RS08270
gene id: 580331:THIT_RS08270
uniprot id: D3T3V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

580331:THIT RS11475
gene id: 580331:THIT_RS11475
uniprot id: D3T6A9
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

580331:THIT RS10080
gene id: 580331:THIT_RS10080
uniprot id: D3T4U8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

580331:THIT RS11110
gene id: 580331:THIT_RS11110
uniprot id: D3T5R0
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

580331:THIT RS08660
gene id: 580331:THIT_RS08660
uniprot id: D3T429
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS11695
gene id: 580331:THIT_RS11695
uniprot id: D3T6F3
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

580331:THIT RS05895
gene id: 580331:THIT_RS05895
uniprot id: D3T915
names: Similarity
messages: Belongs to the ribF family.

580331:THIT RS05855
gene id: 580331:THIT_RS05855
uniprot id: D3T907
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

580331:THIT RS07235
gene id: 580331:THIT_RS07235
uniprot id: D3T3A7
names: Function
names: Subcellular Location Annotation
messages: ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
messages: Cytoplasm

580331:THIT RS00670
gene id: 580331:THIT_RS00670
uniprot id: D3T5F3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

580331:THIT RS08010
gene id: 580331:THIT_RS08010
uniprot id: D3T3Q0
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

580331:THIT RS11115
gene id: 580331:THIT_RS11115
uniprot id: D3T5R1
names: Similarity
messages: Belongs to the GerABKA family.

580331:THIT RS02715
gene id: 580331:THIT_RS02715
uniprot id: D3T7B6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS11050
gene id: 580331:THIT_RS11050
uniprot id: D3T5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS08590
gene id: 580331:THIT_RS08590
uniprot id: D3T415
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

580331:THIT RS01075
gene id: 580331:THIT_RS01075
uniprot id: D3T604
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS09175
gene id: 580331:THIT_RS09175
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS01555
gene id: 580331:THIT_RS01555
uniprot id: D3T6L0
names: Similarity
messages: Belongs to the CapA family.

580331:THIT RS02860
gene id: 580331:THIT_RS02860
uniprot id: D3T7E5
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

580331:THIT RS10290
gene id: 580331:THIT_RS10290
uniprot id: D3T4Y8
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

580331:THIT RS09815
gene id: 580331:THIT_RS09815
uniprot id: D3T4N5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS01040
gene id: 580331:THIT_RS01040
uniprot id: D3T5Z8
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

580331:THIT RS01680
gene id: 580331:THIT_RS01680
uniprot id: D3T6N5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

580331:THIT RS04060
gene id: 580331:THIT_RS04060
uniprot id: D3T808
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

580331:THIT RS01655
gene id: 580331:THIT_RS01655
uniprot id: D3T6N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

580331:THIT RS08155
gene id: 580331:THIT_RS08155
uniprot id: D3T3S8
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

580331:THIT RS09155
gene id: 580331:THIT_RS09155
uniprot id: D3T4C4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

580331:THIT RS09920
gene id: 580331:THIT_RS09920
uniprot id: D3T4R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

580331:THIT RS04040
gene id: 580331:THIT_RS04040
uniprot id: D3T804
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS01315
gene id: 580331:THIT_RS01315
uniprot id: D3T651
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS01755
gene id: 580331:THIT_RS01755
uniprot id: D3T6P9
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

580331:THIT RS01010
gene id: 580331:THIT_RS01010
uniprot id: D3T5Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02330
gene id: 580331:THIT_RS02330
uniprot id: D3T740
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

580331:THIT RS03125
gene id: 580331:THIT_RS03125
uniprot id: D3T7J0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

580331:THIT RS11520
gene id: 580331:THIT_RS11520
uniprot id: D3T6B9
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS09645
gene id: 580331:THIT_RS09645
uniprot id: D3T4L2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

580331:THIT RS09740
gene id: 580331:THIT_RS09740
uniprot id: D3T4M0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

580331:THIT RS02535
gene id: 580331:THIT_RS02535
uniprot id: D3T779
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

580331:THIT RS10870
gene id: 580331:THIT_RS10870
uniprot id: D3T5L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

580331:THIT RS05835
gene id: 580331:THIT_RS05835
uniprot id: D3T903
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

580331:THIT RS04640
gene id: 580331:THIT_RS04640
uniprot id: D3T8C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS07065
gene id: 580331:THIT_RS07065
uniprot id: D3T374
names: Similarity
messages: Belongs to the UPF0047 family.

580331:THIT RS00780
gene id: 580331:THIT_RS00780
uniprot id: D3T5U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

580331:THIT RS09755
gene id: 580331:THIT_RS09755
uniprot id: D3T4M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

580331:THIT RS03315
gene id: 580331:THIT_RS03315
uniprot id: D3T7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

580331:THIT RS04660
gene id: 580331:THIT_RS04660
uniprot id: D3T8C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

580331:THIT RS05210
gene id: 580331:THIT_RS05210
uniprot id: D3T8M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

580331:THIT RS11375
gene id: 580331:THIT_RS11375
uniprot id: D3T693
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

580331:THIT RS03680
gene id: 580331:THIT_RS03680
uniprot id: D3T7U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

580331:THIT RS02680
gene id: 580331:THIT_RS02680
uniprot id: D3T7A9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

580331:THIT RS01865
gene id: 580331:THIT_RS01865
uniprot id: D3T6S1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

580331:THIT RS08275
gene id: 580331:THIT_RS08275
uniprot id: D3T3V3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10370
gene id: 580331:THIT_RS10370
uniprot id: D3T503
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

580331:THIT RS09400
gene id: 580331:THIT_RS09400
uniprot id: D3T4H1
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

580331:THIT RS01275
gene id: 580331:THIT_RS01275
uniprot id: D3T644
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

580331:THIT RS00275
gene id: 580331:THIT_RS00275
uniprot id: D3T575
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05985
gene id: 580331:THIT_RS05985
uniprot id: D3T2L3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS06675
gene id: 580331:THIT_RS06675
uniprot id: D3T2Z8
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

580331:THIT RS04470
gene id: 580331:THIT_RS04470
uniprot id: D3T888
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

580331:THIT RS07445
gene id: 580331:THIT_RS07445
uniprot id: D3T3E9
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

580331:THIT RS00980
gene id: 580331:THIT_RS00980
uniprot id: D3T5Y6
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Homodimer.

580331:THIT RS02235
gene id: 580331:THIT_RS02235
uniprot id: D3T724
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

580331:THIT RS03195
gene id: 580331:THIT_RS03195
uniprot id: D3T7K4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS01280
gene id: 580331:THIT_RS01280
uniprot id: D3T645
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

580331:THIT RS11990
gene id: 580331:THIT_RS11990
uniprot id: D3T6X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

580331:THIT RS00115
gene id: 580331:THIT_RS00115
uniprot id: D3T552
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

580331:THIT RS05875
gene id: 580331:THIT_RS05875
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS09885
gene id: 580331:THIT_RS09885
uniprot id: D3T4P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

580331:THIT RS11550
gene id: 580331:THIT_RS11550
uniprot id: D3T6C4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS07365
gene id: 580331:THIT_RS07365
uniprot id: D3T3D3
names: Similarity
messages: Belongs to the UPF0749 family.

580331:THIT RS01795
gene id: 580331:THIT_RS01795
uniprot id: D3T6Q7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

580331:THIT RS01830
gene id: 580331:THIT_RS01830
uniprot id: D3T6R4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

580331:THIT RS03150
gene id: 580331:THIT_RS03150
uniprot id: D3T7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

580331:THIT RS11345
gene id: 580331:THIT_RS11345
uniprot id: D3T687
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

580331:THIT RS10880
gene id: 580331:THIT_RS10880
uniprot id: D3T5L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

580331:THIT RS04545
gene id: 580331:THIT_RS04545
uniprot id: D3T8A2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

580331:THIT RS00835
gene id: 580331:THIT_RS00835
uniprot id: D3T5V6
names: Similarity
messages: Belongs to the UxaA family.

580331:THIT RS09165
gene id: 580331:THIT_RS09165
uniprot id: D3T4C6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

580331:THIT RS07415
gene id: 580331:THIT_RS07415
uniprot id: D3T3E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

580331:THIT RS04045
gene id: 580331:THIT_RS04045
uniprot id: D3T805
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

580331:THIT RS04245
gene id: 580331:THIT_RS04245
uniprot id: D3T844
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

580331:THIT RS11380
gene id: 580331:THIT_RS11380
uniprot id: D3T694
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

580331:THIT RS08185
gene id: 580331:THIT_RS08185
uniprot id: D3T3T4
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

580331:THIT RS00100
gene id: 580331:THIT_RS00100
uniprot id: D3T549
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

580331:THIT RS05530
gene id: 580331:THIT_RS05530
uniprot id: D3T8U3
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

580331:THIT RS00755
gene id: 580331:THIT_RS00755
uniprot id: D3T5T9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10165
gene id: 580331:THIT_RS10165
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS06185
gene id: 580331:THIT_RS06185
uniprot id: D3T2Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.

580331:THIT RS06195
gene id: 580331:THIT_RS06195
uniprot id: D3T2Q3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

580331:THIT RS05100
gene id: 580331:THIT_RS05100
uniprot id: D3T8K7
names: Similarity
messages: Belongs to the RecJ family.

580331:THIT RS02440
gene id: 580331:THIT_RS02440
uniprot id: D3T762
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

580331:THIT RS07355
gene id: 580331:THIT_RS07355
uniprot id: D3T3D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

580331:THIT RS01855
gene id: 580331:THIT_RS01855
uniprot id: D3T6R9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS09055
gene id: 580331:THIT_RS09055
uniprot id: D3T4A5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

580331:THIT RS08550
gene id: 580331:THIT_RS08550
uniprot id: D3T407
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

580331:THIT RS11675
gene id: 580331:THIT_RS11675
uniprot id: D3T6E9
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS05370
gene id: 580331:THIT_RS05370
uniprot id: D3T8R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

580331:THIT RS08705
gene id: 580331:THIT_RS08705
uniprot id: D3T438
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS11255
gene id: 580331:THIT_RS11255
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS06515
gene id: 580331:THIT_RS06515
uniprot id: D3T2W8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

580331:THIT RS05205
gene id: 580331:THIT_RS05205
uniprot id: D3T8M7
names: Similarity
messages: Belongs to the UPF0297 family.

580331:THIT RS10230
gene id: 580331:THIT_RS10230
uniprot id: D3T4X6
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

580331:THIT RS09535
gene id: 580331:THIT_RS09535
uniprot id: D3T4J3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

580331:THIT RS00630
gene id: 580331:THIT_RS00630
uniprot id: D3T5E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

580331:THIT RS06600
gene id: 580331:THIT_RS06600
uniprot id: D3T2Y5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

580331:THIT RS02745
gene id: 580331:THIT_RS02745
uniprot id: D3T7C2
names: Similarity
messages: Belongs to the glutamate synthase family.

580331:THIT RS01735
gene id: 580331:THIT_RS01735
uniprot id: D3T6P5
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

580331:THIT RS06440
gene id: 580331:THIT_RS06440
uniprot id: D3T2V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

580331:THIT RS02685
gene id: 580331:THIT_RS02685
uniprot id: D3T7B0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS10910
gene id: 580331:THIT_RS10910
uniprot id: D3T5L9
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

580331:THIT RS07755
gene id: 580331:THIT_RS07755
uniprot id: D3T3J8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

580331:THIT RS06275
gene id: 580331:THIT_RS06275
uniprot id: D3T2R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

580331:THIT RS02430
gene id: 580331:THIT_RS02430
uniprot id: D3T760
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

580331:THIT RS02960
gene id: 580331:THIT_RS02960
uniprot id: D3T7G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

580331:THIT RS05065
gene id: 580331:THIT_RS05065
uniprot id: D3T8J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

580331:THIT RS11195
gene id: 580331:THIT_RS11195
uniprot id: D3T5S7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

580331:THIT RS06200
gene id: 580331:THIT_RS06200
uniprot id: D3T2Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

580331:THIT RS11360
gene id: 580331:THIT_RS11360
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS07305
gene id: 580331:THIT_RS07305
uniprot id: D3T3C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

580331:THIT RS10860
gene id: 580331:THIT_RS10860
uniprot id: D3T5L0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

580331:THIT RS08085
gene id: 580331:THIT_RS08085
uniprot id: D3T3R4
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

580331:THIT RS00605
gene id: 580331:THIT_RS00605
uniprot id: D3T5D9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

580331:THIT RS05135
gene id: 580331:THIT_RS05135
uniprot id: D3T8L4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

580331:THIT RS06280
gene id: 580331:THIT_RS06280
uniprot id: D3T2S0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

580331:THIT RS03295
gene id: 580331:THIT_RS03295
uniprot id: D3T7M1
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

580331:THIT RS07300
gene id: 580331:THIT_RS07300
uniprot id: D3T3C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

580331:THIT RS00700
gene id: 580331:THIT_RS00700
uniprot id: D3T5F8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

580331:THIT RS03700
gene id: 580331:THIT_RS03700
uniprot id: D3T7U4
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

580331:THIT RS11180
gene id: 580331:THIT_RS11180
uniprot id: D3T5S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Membrane

580331:THIT RS11480
gene id: 580331:THIT_RS11480
uniprot id: D3T6B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Heptamer of 7 subunits arranged in a ring.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

580331:THIT RS05015
gene id: 580331:THIT_RS05015
uniprot id: D3T8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

580331:THIT RS08795
gene id: 580331:THIT_RS08795
uniprot id: D3T456
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

580331:THIT RS07750
gene id: 580331:THIT_RS07750
uniprot id: D3T3J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

580331:THIT RS09030
gene id: 580331:THIT_RS09030
uniprot id: D3T4A0
names: Similarity
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.

580331:THIT RS08285
gene id: 580331:THIT_RS08285
uniprot id: D3T3V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

580331:THIT RS06565
gene id: 580331:THIT_RS06565
uniprot id: D3T2X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

580331:THIT RS00620
gene id: 580331:THIT_RS00620
uniprot id: D3T5E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

580331:THIT RS11460
gene id: 580331:THIT_RS11460
uniprot id: D3T6A6
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

580331:THIT RS11505
gene id: 580331:THIT_RS11505
uniprot id: D3T6B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS09790
gene id: 580331:THIT_RS09790
uniprot id: D3T4N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

580331:THIT RS07375
gene id: 580331:THIT_RS07375
uniprot id: D3T3D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS09060
gene id: 580331:THIT_RS09060
uniprot id: D3T4A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

580331:THIT RS08500
gene id: 580331:THIT_RS08500
uniprot id: D3T3Z7
names: Similarity
messages: Belongs to the ribulokinase family.

580331:THIT RS06425
gene id: 580331:THIT_RS06425
uniprot id: D3T2V0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10385
gene id: 580331:THIT_RS10385
uniprot id: D3T506
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS08040
gene id: 580331:THIT_RS08040
uniprot id: D3T3Q5
names: Similarity
messages: Belongs to the HypE family.

580331:THIT RS05035
gene id: 580331:THIT_RS05035
uniprot id: D3T8J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

580331:THIT RS08075
gene id: 580331:THIT_RS08075
uniprot id: D3T3R2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

580331:THIT RS09960
gene id: 580331:THIT_RS09960
uniprot id: D3T4S4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

580331:THIT RS07480
gene id: 580331:THIT_RS07480
uniprot id: D3T3F6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

580331:THIT RS03270
gene id: 580331:THIT_RS03270
uniprot id: D3T7L6
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

580331:THIT RS09550
gene id: 580331:THIT_RS09550
uniprot id: D3T4J5
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

580331:THIT RS08000
gene id: 580331:THIT_RS08000
uniprot id: D3T3P8
names: Similarity
messages: Belongs to the manganese catalase family.

580331:THIT RS11655
gene id: 580331:THIT_RS11655
uniprot id: D3T6E5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

580331:THIT RS10850
gene id: 580331:THIT_RS10850
uniprot id: D3T5K8
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS02775
gene id: 580331:THIT_RS02775
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS11240
gene id: 580331:THIT_RS11240
uniprot id: D3T665
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

580331:THIT RS06155
gene id: 580331:THIT_RS06155
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS02830
gene id: 580331:THIT_RS02830
uniprot id: D3T7D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

580331:THIT RS00165
gene id: 580331:THIT_RS00165
uniprot id: D3T560
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

580331:THIT RS02400
gene id: 580331:THIT_RS02400
uniprot id: D3T754
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

580331:THIT RS09240
gene id: 580331:THIT_RS09240
uniprot id: D3T4E0
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
messages: Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.

580331:THIT RS08065
gene id: 580331:THIT_RS08065
uniprot id: D3T3R0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

580331:THIT RS08700
gene id: 580331:THIT_RS08700
uniprot id: D3T437
names: Similarity
messages: Belongs to the FGGY kinase family.

580331:THIT RS05740
gene id: 580331:THIT_RS05740
uniprot id: D3T8Y4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

580331:THIT RS04050
gene id: 580331:THIT_RS04050
uniprot id: D3T806
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

580331:THIT RS10095
gene id: 580331:THIT_RS10095
uniprot id: D3T4V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS06300
gene id: 580331:THIT_RS06300
uniprot id: D3T2S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

580331:THIT RS04300
gene id: 580331:THIT_RS04300
uniprot id: D3T855
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

580331:THIT RS09280
gene id: 580331:THIT_RS09280
uniprot id: D3T4E8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS01615
gene id: 580331:THIT_RS01615
uniprot id: D3T6M2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

580331:THIT RS02815
gene id: 580331:THIT_RS02815
uniprot id: D3T7D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

580331:THIT RS09675
gene id: 580331:THIT_RS09675
uniprot id: D3T4L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

580331:THIT RS06390
gene id: 580331:THIT_RS06390
uniprot id: D3T2U3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

580331:THIT RS10205
gene id: 580331:THIT_RS10205
uniprot id: D3T4X1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS08830
gene id: 580331:THIT_RS08830
uniprot id: D3T463
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

580331:THIT RS10195
gene id: 580331:THIT_RS10195
uniprot id: D3T4W9
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

580331:THIT RS00010
gene id: 580331:THIT_RS00010
uniprot id: D3T4Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

580331:THIT RS11410
gene id: 580331:THIT_RS11410
uniprot id: D3T699
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

580331:THIT RS01095
gene id: 580331:THIT_RS01095
uniprot id: D3T608
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS08900
gene id: 580331:THIT_RS08900
uniprot id: D3T475
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

580331:THIT RS08595
gene id: 580331:THIT_RS08595
uniprot id: D3T416
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

580331:THIT RS07595
gene id: 580331:THIT_RS07595
uniprot id: D3T3H8
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS06595
gene id: 580331:THIT_RS06595
uniprot id: D3T2Y4
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

580331:THIT RS02065
gene id: 580331:THIT_RS02065
uniprot id: D3T6Z0
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS08620
gene id: 580331:THIT_RS08620
uniprot id: D3T421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

580331:THIT RS08540
gene id: 580331:THIT_RS08540
uniprot id: D3T405
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS04895
gene id: 580331:THIT_RS04895
uniprot id: D3T8G6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

580331:THIT RS02085
gene id: 580331:THIT_RS02085
uniprot id: D3T6Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

580331:THIT RS10790
gene id: 580331:THIT_RS10790
uniprot id: D3T5J8
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

580331:THIT RS10430
gene id: 580331:THIT_RS10430
uniprot id: D3T515
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

580331:THIT RS11315
gene id: 580331:THIT_RS11315
uniprot id: D3T680
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

580331:THIT RS04505
gene id: 580331:THIT_RS04505
uniprot id: D3T895
names: Similarity
names: Subunit
messages: Belongs to the UPF0210 family.
messages: Homodimer.

580331:THIT RS05125
gene id: 580331:THIT_RS05125
uniprot id: D3T8L2
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS11915
gene id: 580331:THIT_RS11915
uniprot id: D3T6W2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).
messages: Homodimer.
messages: In the C-terminal section; belongs to the MurCDEF family.

580331:THIT RS03160
gene id: 580331:THIT_RS03160
uniprot id: D3T7J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

580331:THIT RS00640
gene id: 580331:THIT_RS00640
uniprot id: D3T5E7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

580331:THIT RS00760
gene id: 580331:THIT_RS00760
uniprot id: D3T5U0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

580331:THIT RS00125
gene id: 580331:THIT_RS00125
uniprot id: D3T555
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

580331:THIT RS10125
gene id: 580331:THIT_RS10125
uniprot id: D3T4V6
names: Activity Regulation
names: Function
names: Similarity
messages: Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.

580331:THIT RS09840
gene id: 580331:THIT_RS09840
uniprot id: D3T4P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

580331:THIT RS01305
gene id: 580331:THIT_RS01305
uniprot id: D3T649
names: Similarity
messages: Belongs to the OsmC/Ohr family.

580331:THIT RS02190
gene id: 580331:THIT_RS02190
uniprot id: D3T715
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS05545
gene id: 580331:THIT_RS05545
uniprot id: D3T8U6
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.

580331:THIT RS08215
gene id: 580331:THIT_RS08215
uniprot id: D3T3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS11340
gene id: 580331:THIT_RS11340
uniprot id: D3T686
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

580331:THIT RS07100
gene id: 580331:THIT_RS07100
uniprot id: D3T381
names: Similarity
messages: Belongs to the TrpC family.

580331:THIT RS00875
gene id: 580331:THIT_RS00875
uniprot id: D3T5W4
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS05340
gene id: 580331:THIT_RS05340
uniprot id: D3T8Q4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

580331:THIT RS07890
gene id: 580331:THIT_RS07890
uniprot id: D3T3M5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS09235
gene id: 580331:THIT_RS09235
uniprot id: D3T4D9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS10365
gene id: 580331:THIT_RS10365
uniprot id: D3T502
names: Similarity
messages: Belongs to the EamA transporter family.

580331:THIT RS00440
gene id: 580331:THIT_RS00440
uniprot id: D3T5A6
names: Similarity
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

580331:THIT RS11920
gene id: 580331:THIT_RS11920
uniprot id: D3T6W3
names: Function
names: Similarity
messages: Belongs to the peptidase S51 family.
messages: Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.

580331:THIT RS10770
gene id: 580331:THIT_RS10770
uniprot id: D3T5J4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

580331:THIT RS05660
gene id: 580331:THIT_RS05660
uniprot id: D3T6U7
names: Function
messages: Involved in the transposition of the insertion sequence.

580331:THIT RS06500
gene id: 580331:THIT_RS06500
uniprot id: D3T2W5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

580331:THIT RS08695
gene id: 580331:THIT_RS08695
uniprot id: D3T436
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

580331:THIT RS07080
gene id: 580331:THIT_RS07080
uniprot id: D3T377
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

580331:THIT RS08360
gene id: 580331:THIT_RS08360
uniprot id: D3T3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

580331:THIT RS03830
gene id: 580331:THIT_RS03830
uniprot id: D3T7W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S8 family.
messages: Monomer.
messages: Serine protease with a broad substrate specificity.

580331:THIT RS03180
gene id: 580331:THIT_RS03180
uniprot id: D3T7K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS00145
gene id: 580331:THIT_RS00145
uniprot id: D3T557
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

580331:THIT RS05580
gene id: 580331:THIT_RS05580
uniprot id: D3T8V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

580331:THIT RS04860
gene id: 580331:THIT_RS04860
uniprot id: D3T8F9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

580331:THIT RS07760
gene id: 580331:THIT_RS07760
uniprot id: D3T3J9
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

580331:THIT RS04210
gene id: 580331:THIT_RS04210
uniprot id: D3T837
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

580331:THIT RS07245
gene id: 580331:THIT_RS07245
uniprot id: D3T3A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

580331:THIT RS10155
gene id: 580331:THIT_RS10155
uniprot id: D3T4W1
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

580331:THIT RS04185
gene id: 580331:THIT_RS04185
uniprot id: D3T832
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

580331:THIT RS06455
gene id: 580331:THIT_RS06455
uniprot id: D3T2V6
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

580331:THIT RS05960
gene id: 580331:THIT_RS05960
uniprot id: D3T2K8
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10145
gene id: 580331:THIT_RS10145
uniprot id: D3T4W0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

580331:THIT RS03310
gene id: 580331:THIT_RS03310
uniprot id: D3T7M4
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

580331:THIT RS06370
gene id: 580331:THIT_RS06370
uniprot id: D3T2T9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

580331:THIT RS01520
gene id: 580331:THIT_RS01520
uniprot id: D3T6K4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

580331:THIT RS10210
gene id: 580331:THIT_RS10210
uniprot id: D3T4X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

580331:THIT RS05675
gene id: 580331:THIT_RS05675
uniprot id: D3T8X3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

580331:THIT RS09650
gene id: 580331:THIT_RS09650
uniprot id: D3T4L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CotF family.
messages: Spore coat

580331:THIT RS10475
gene id: 580331:THIT_RS10475
uniprot id: D3T524
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

580331:THIT RS08940
gene id: 580331:THIT_RS08940
uniprot id: D3T482
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

580331:THIT RS01060
gene id: 580331:THIT_RS01060
uniprot id: D3T602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

580331:THIT RS07420
gene id: 580331:THIT_RS07420
uniprot id: D3T3E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

580331:THIT RS04260
gene id: 580331:THIT_RS04260
uniprot id: D3T847
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

580331:THIT RS08050
gene id: 580331:THIT_RS08050
uniprot id: D3T3Q7
names: Similarity
messages: Belongs to the HupF/HypC family.

580331:THIT RS04495
gene id: 580331:THIT_RS04495
uniprot id: D3T893
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

580331:THIT RS07425
gene id: 580331:THIT_RS07425
uniprot id: D3T3E5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

580331:THIT RS03095
gene id: 580331:THIT_RS03095
uniprot id: D3T7I5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS10105
gene id: 580331:THIT_RS10105
uniprot id: D3T4V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

580331:THIT RS06110
gene id: 580331:THIT_RS06110
uniprot id: D3T2N8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

580331:THIT RS02850
gene id: 580331:THIT_RS02850
uniprot id: D3T7E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

580331:THIT RS05755
gene id: 580331:THIT_RS05755
uniprot id: D3T8Y7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

580331:THIT RS08800
gene id: 580331:THIT_RS08800
uniprot id: D3T457
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

580331:THIT RS01150
gene id: 580331:THIT_RS01150
uniprot id: D3T619
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

580331:THIT RS01660
gene id: 580331:THIT_RS01660
uniprot id: D3T6N1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

580331:THIT RS07485
gene id: 580331:THIT_RS07485
uniprot id: D3T3F7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

580331:THIT RS05105
gene id: 580331:THIT_RS05105
uniprot id: D3T8K8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS02150
gene id: 580331:THIT_RS02150
uniprot id: D3T707
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS11660
gene id: 580331:THIT_RS11660
uniprot id: D3T6E6
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

580331:THIT RS09945
gene id: 580331:THIT_RS09945
uniprot id: D3T4S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

580331:THIT RS11620
gene id: 580331:THIT_RS11620
uniprot id: D3T6D7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

580331:THIT RS06555
gene id: 580331:THIT_RS06555
uniprot id: D3T2X6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS03140
gene id: 580331:THIT_RS03140
uniprot id: D3T7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

580331:THIT RS11260
gene id: 580331:THIT_RS11260
uniprot id: D3T669
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

580331:THIT RS04485
gene id: 580331:THIT_RS04485
uniprot id: D3T891
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

580331:THIT RS11610
gene id: 580331:THIT_RS11610
uniprot id: D3T6D5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

580331:THIT RS06775
gene id: 580331:THIT_RS06775
uniprot id: D3T317
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

580331:THIT RS06095
gene id: 580331:THIT_RS06095
uniprot id: D3T2N5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

580331:THIT RS10730
gene id: 580331:THIT_RS10730
uniprot id: D3T5I6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS01340
gene id: 580331:THIT_RS01340
uniprot id: D3T655
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS00350
gene id: 580331:THIT_RS00350
uniprot id: D3T591
names: Similarity
messages: Belongs to the class-I fumarase family.

580331:THIT RS02260
gene id: 580331:THIT_RS02260
uniprot id: D3T729
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS06050
gene id: 580331:THIT_RS06050
uniprot id: D3T2M6
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

580331:THIT RS03755
gene id: 580331:THIT_RS03755
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS00575
gene id: 580331:THIT_RS00575
uniprot id: D3T5D3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS03620
gene id: 580331:THIT_RS03620
uniprot id: D3T7T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Amj family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.

580331:THIT RS06365
gene id: 580331:THIT_RS06365
uniprot id: D3T2T8
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

580331:THIT RS00345
gene id: 580331:THIT_RS00345
uniprot id: D3T590
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

580331:THIT RS05445
gene id: 580331:THIT_RS05445
uniprot id: D3T8S5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

580331:THIT RS10795
gene id: 580331:THIT_RS10795
uniprot id: D3T5J9
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS08655
gene id: 580331:THIT_RS08655
uniprot id: D3T428
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

580331:THIT RS11965
gene id: 580331:THIT_RS11965
uniprot id: D3T6X2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

580331:THIT RS05150
gene id: 580331:THIT_RS05150
uniprot id: D3T8L6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

580331:THIT RS08865
gene id: 580331:THIT_RS08865
uniprot id: D3T470
names: Similarity
messages: Belongs to the CdaR family.

580331:THIT RS02805
gene id: 580331:THIT_RS02805
uniprot id: D3T7D4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

580331:THIT RS00920
gene id: 580331:THIT_RS00920
uniprot id: D3T5X4
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

580331:THIT RS03120
gene id: 580331:THIT_RS03120
uniprot id: D3T7I9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

580331:THIT RS07155
gene id: 580331:THIT_RS07155
uniprot id: D3T392
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS02010
gene id: 580331:THIT_RS02010
uniprot id: D3T6X9
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
messages: Belongs to the radical SAM superfamily. NifB family.

580331:THIT RS00300
gene id: 580331:THIT_RS00300
uniprot id: D3T581
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

580331:THIT RS06215
gene id: 580331:THIT_RS06215
uniprot id: D3T2Q7
names: Similarity
messages: Belongs to the UPF0102 family.

580331:THIT RS07790
gene id: 580331:THIT_RS07790
uniprot id: D3T3K5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS03890
gene id: 580331:THIT_RS03890
uniprot id: D3T7X5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

580331:THIT RS06350
gene id: 580331:THIT_RS06350
uniprot id: D3T2T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02205
gene id: 580331:THIT_RS02205
uniprot id: D3T718
names: Function
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: This protein is a Fe-Mo-cofactor biosynthetic component.

580331:THIT RS04755
gene id: 580331:THIT_RS04755
uniprot id: D3T8D9
names: Similarity
messages: Belongs to the peptidase C56 family.

580331:THIT RS05610
gene id: 580331:THIT_RS05610
uniprot id: D3T8V9
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

580331:THIT RS01480
gene id: 580331:THIT_RS01480
uniprot id: D3T6J6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

580331:THIT RS09285
gene id: 580331:THIT_RS09285
uniprot id: D3T4E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

580331:THIT RS09855
gene id: 580331:THIT_RS09855
uniprot id: D3T4P3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

580331:THIT RS10285
gene id: 580331:THIT_RS10285
uniprot id: D3T4Y7
names: Similarity
messages: Belongs to the GerABKA family.

580331:THIT RS10375
gene id: 580331:THIT_RS10375
uniprot id: D3T504
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

580331:THIT RS08320
gene id: 580331:THIT_RS08320
uniprot id: D3T3W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

580331:THIT RS08815
gene id: 580331:THIT_RS08815
uniprot id: D3T460
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS03580
gene id: 580331:THIT_RS03580
uniprot id: D3T7S2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

580331:THIT RS09925
gene id: 580331:THIT_RS09925
uniprot id: D3T4R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

580331:THIT RS02070
gene id: 580331:THIT_RS02070
uniprot id: D3T6Z1
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

580331:THIT RS03050
gene id: 580331:THIT_RS03050
uniprot id: D3T7H5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

580331:THIT RS10115
gene id: 580331:THIT_RS10115
uniprot id: D3T4V4
names: Similarity
messages: Belongs to the DtxR/MntR family.

580331:THIT RS00895
gene id: 580331:THIT_RS00895
uniprot id: D3T5W8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS05870
gene id: 580331:THIT_RS05870
uniprot id: D3T910
names: Similarity
messages: Belongs to the peptidase M16 family.

580331:THIT RS05000
gene id: 580331:THIT_RS05000
uniprot id: D3T8I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

580331:THIT RS07250
gene id: 580331:THIT_RS07250
uniprot id: D3T3B0
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

580331:THIT RS05820
gene id: 580331:THIT_RS05820
uniprot id: D3T900
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

580331:THIT RS05040
gene id: 580331:THIT_RS05040
uniprot id: D3T8J4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

580331:THIT RS06055
gene id: 580331:THIT_RS06055
uniprot id: D3T2M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

580331:THIT RS05625
gene id: 580331:THIT_RS05625
uniprot id: D3T8W2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

580331:THIT RS08180
gene id: 580331:THIT_RS08180
uniprot id: D3T3T3
names: Function
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

580331:THIT RS05245
gene id: 580331:THIT_RS05245
uniprot id: D3T8N5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS08095
gene id: 580331:THIT_RS08095
uniprot id: D3T3R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Membrane

580331:THIT RS05005
gene id: 580331:THIT_RS05005
uniprot id: D3T8I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02825
gene id: 580331:THIT_RS02825
uniprot id: D3T7D8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

580331:THIT RS01835
gene id: 580331:THIT_RS01835
uniprot id: D3T6R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

580331:THIT RS01765
gene id: 580331:THIT_RS01765
uniprot id: D3T6Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

580331:THIT RS06260
gene id: 580331:THIT_RS06260
uniprot id: D3T2R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

580331:THIT RS10255
gene id: 580331:THIT_RS10255
uniprot id: D3T4Y1
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

580331:THIT RS09050
gene id: 580331:THIT_RS09050
uniprot id: D3T4A4
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

580331:THIT RS04295
gene id: 580331:THIT_RS04295
uniprot id: D3T854
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

580331:THIT RS03040
gene id: 580331:THIT_RS03040
uniprot id: D3T7H3
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

580331:THIT RS00415
gene id: 580331:THIT_RS00415
uniprot id: D3T5A1
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

580331:THIT RS01670
gene id: 580331:THIT_RS01670
uniprot id: D3T6N3
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

580331:THIT RS01560
gene id: 580331:THIT_RS01560
uniprot id: D3T6L1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

580331:THIT RS06535
gene id: 580331:THIT_RS06535
uniprot id: D3T2X2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

580331:THIT RS03920
gene id: 580331:THIT_RS03920
uniprot id: D3T7Y1
names: Similarity
messages: Belongs to the glutamine synthetase family.

580331:THIT RS04035
gene id: 580331:THIT_RS04035
uniprot id: D3T803
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS03775
gene id: 580331:THIT_RS03775
uniprot id: D3T7V4
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

580331:THIT RS07410
gene id: 580331:THIT_RS07410
uniprot id: D3T3E2
names: Similarity
messages: Belongs to the transpeptidase family.

580331:THIT RS10175
gene id: 580331:THIT_RS10175
uniprot id: D3T4W5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

580331:THIT RS02620
gene id: 580331:THIT_RS02620
uniprot id: D3T796
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

580331:THIT RS02495
gene id: 580331:THIT_RS02495
uniprot id: D3T773
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.

580331:THIT RS01825
gene id: 580331:THIT_RS01825
uniprot id: D3T6R3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

580331:THIT RS11085
gene id: 580331:THIT_RS11085
uniprot id: D3T5Q5
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

580331:THIT RS11190
gene id: 580331:THIT_RS11190
uniprot id: D3T5S6
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS05715
gene id: 580331:THIT_RS05715
uniprot id: D3T8Y0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

580331:THIT RS10420
gene id: 580331:THIT_RS10420
uniprot id: D3T513
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

580331:THIT RS03070
gene id: 580331:THIT_RS03070
uniprot id: D3T7H9
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS04885
gene id: 580331:THIT_RS04885
uniprot id: D3T8G4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

580331:THIT RS11020
gene id: 580331:THIT_RS11020
uniprot id: D3T5P2
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

580331:THIT RS06075
gene id: 580331:THIT_RS06075
uniprot id: D3T2N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

580331:THIT RS09970
gene id: 580331:THIT_RS09970
uniprot id: D3T4S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

580331:THIT RS05435
gene id: 580331:THIT_RS05435
uniprot id: D3T8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

580331:THIT RS04865
gene id: 580331:THIT_RS04865
uniprot id: D3T8G0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS11350
gene id: 580331:THIT_RS11350
uniprot id: D3T688
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

580331:THIT RS01635
gene id: 580331:THIT_RS01635
uniprot id: D3T6M6
names: Similarity
messages: Belongs to the Fur family.

580331:THIT RS02630
gene id: 580331:THIT_RS02630
uniprot id: D3T798
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02640
gene id: 580331:THIT_RS02640
uniprot id: D3T7A1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS05825
gene id: 580331:THIT_RS05825
uniprot id: D3T901
names: Similarity
messages: Belongs to the CinA family.

580331:THIT RS03495
gene id: 580331:THIT_RS03495
uniprot id: D3T7Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

580331:THIT RS03880
gene id: 580331:THIT_RS03880
uniprot id: D3T7X3
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family. DapH subfamily.
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.

580331:THIT RS11080
gene id: 580331:THIT_RS11080
uniprot id: D3T5Q4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

580331:THIT RS02445
gene id: 580331:THIT_RS02445
uniprot id: D3T763
names: Similarity
messages: Belongs to the asparagine synthetase family.

580331:THIT RS07170
gene id: 580331:THIT_RS07170
uniprot id: D3T395
names: Subcellular Location Annotation
messages: Cytoplasm

580331:THIT RS06560
gene id: 580331:THIT_RS06560
uniprot id: D3T2X7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

580331:THIT RS01485
gene id: 580331:THIT_RS01485
uniprot id: D3T6J7
names: Similarity
messages: Belongs to the Tlp family.

580331:THIT RS03990
gene id: 580331:THIT_RS03990
uniprot id: D3T7Z4
names: Similarity
messages: Belongs to the UPF0340 family.

580331:THIT RS11960
gene id: 580331:THIT_RS11960
uniprot id: D3T6X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

580331:THIT RS04835
gene id: 580331:THIT_RS04835
uniprot id: D3T8F4
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS08350
gene id: 580331:THIT_RS08350
uniprot id: D3T3W7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

580331:THIT RS05910
gene id: 580331:THIT_RS05910
uniprot id: D3T918
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

580331:THIT RS11335
gene id: 580331:THIT_RS11335
uniprot id: D3T685
names: Similarity
messages: Belongs to the peptidase S41A family.

580331:THIT RS06415
gene id: 580331:THIT_RS06415
uniprot id: D3T2U8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

580331:THIT RS06450
gene id: 580331:THIT_RS06450
uniprot id: D3T2V5
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

580331:THIT RS00935
gene id: 580331:THIT_RS00935
uniprot id: D3T5X7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

580331:THIT RS08835
gene id: 580331:THIT_RS08835
uniprot id: D3T464
names: Similarity
messages: Belongs to the ComB family.

580331:THIT RS06580
gene id: 580331:THIT_RS06580
uniprot id: D3T2Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS08785
gene id: 580331:THIT_RS08785
uniprot id: D3T454
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

580331:THIT RS08845
gene id: 580331:THIT_RS08845
uniprot id: D3T466
names: Similarity
messages: Belongs to the peptidase S41A family.

580331:THIT RS03560
gene id: 580331:THIT_RS03560
uniprot id: D3T7R8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

580331:THIT RS00765
gene id: 580331:THIT_RS00765
uniprot id: D3T5U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

580331:THIT RS07845
gene id: 580331:THIT_RS07845
uniprot id: D3T3L6
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

580331:THIT RS04850
gene id: 580331:THIT_RS04850
uniprot id: D3T8F7
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

580331:THIT RS05950
gene id: 580331:THIT_RS05950
uniprot id: D3T2K6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

580331:THIT RS08120
gene id: 580331:THIT_RS08120
uniprot id: D3T3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02520
gene id: 580331:THIT_RS02520
uniprot id: D3T776
names: Similarity
messages: Belongs to the histone deacetylase family.

580331:THIT RS09965
gene id: 580331:THIT_RS09965
uniprot id: D3T4S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

580331:THIT RS07350
gene id: 580331:THIT_RS07350
uniprot id: D3T3D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

580331:THIT RS06060
gene id: 580331:THIT_RS06060
uniprot id: D3T2M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

580331:THIT RS07225
gene id: 580331:THIT_RS07225
uniprot id: D3T3A6
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

580331:THIT RS05885
gene id: 580331:THIT_RS05885
uniprot id: D3T913
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

580331:THIT RS10855
gene id: 580331:THIT_RS10855
uniprot id: D3T5K9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS08480
gene id: 580331:THIT_RS08480
uniprot id: D3T3Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

580331:THIT RS01355
gene id: 580331:THIT_RS01355
uniprot id: D3T657
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

580331:THIT RS02765
gene id: 580331:THIT_RS02765
uniprot id: D3T7C6
names: Similarity
messages: Belongs to the peptidase S8 family.

580331:THIT RS00730
gene id: 580331:THIT_RS00730
uniprot id: D3T5T4
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

580331:THIT RS04790
gene id: 580331:THIT_RS04790
uniprot id: D3T8E5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

580331:THIT RS00790
gene id: 580331:THIT_RS00790
uniprot id: D3T5U7
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

580331:THIT RS04370
gene id: 580331:THIT_RS04370
uniprot id: D3T867
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

580331:THIT RS04975
gene id: 580331:THIT_RS04975
uniprot id: D3T8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

580331:THIT RS08430
gene id: 580331:THIT_RS08430
uniprot id: D3T3Y4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

580331:THIT RS09020
gene id: 580331:THIT_RS09020
uniprot id: D3T498
names: Similarity
messages: Belongs to the phosphohexose mutase family.

580331:THIT RS03925
gene id: 580331:THIT_RS03925
uniprot id: D3T7Y2
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS04320
gene id: 580331:THIT_RS04320
uniprot id: D3T859
names: Similarity
messages: Belongs to the asparagine synthetase family.

580331:THIT RS02650
gene id: 580331:THIT_RS02650
uniprot id: D3T7A3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS01265
gene id: 580331:THIT_RS01265
uniprot id: D3T642
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS09860
gene id: 580331:THIT_RS09860
uniprot id: D3T4P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

580331:THIT RS07945
gene id: 580331:THIT_RS07945
uniprot id: D3T3N6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

580331:THIT RS00355
gene id: 580331:THIT_RS00355
uniprot id: D3T592
names: Similarity
messages: Belongs to the class-I fumarase family.

580331:THIT RS11890
gene id: 580331:THIT_RS11890
uniprot id: D3T6V7
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

580331:THIT RS00030
gene id: 580331:THIT_RS00030
uniprot id: D3T4R2
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

580331:THIT RS00020
gene id: 580331:THIT_RS00020
uniprot id: D3T4R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

580331:THIT RS07895
gene id: 580331:THIT_RS07895
uniprot id: D3T3M6
names: Similarity
messages: Belongs to the DapA family.

580331:THIT RS07770
gene id: 580331:THIT_RS07770
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS07135
gene id: 580331:THIT_RS07135
uniprot id: D3T388
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

580331:THIT RS11930
gene id: 580331:THIT_RS11930
uniprot id: D3T6W5
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

580331:THIT RS02360
gene id: 580331:THIT_RS02360
uniprot id: D3T746
names: Similarity
messages: Belongs to the bacterial flagellin family.

580331:THIT RS01590
gene id: 580331:THIT_RS01590
uniprot id: D3T6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05475
gene id: 580331:THIT_RS05475
uniprot id: D3T8T1
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

580331:THIT RS03035
gene id: 580331:THIT_RS03035
uniprot id: D3T7H2
names: Function
messages: Involved in the transposition of the insertion sequence.

580331:THIT RS02170
gene id: 580331:THIT_RS02170
uniprot id: D3T711
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

580331:THIT RS05460
gene id: 580331:THIT_RS05460
uniprot id: D3T8S8
names: Similarity
messages: Belongs to the TlyA family.

580331:THIT RS01820
gene id: 580331:THIT_RS01820
uniprot id: D3T6R2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

580331:THIT RS06230
gene id: 580331:THIT_RS06230
uniprot id: D3T2R0
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

580331:THIT RS11980
gene id: 580331:THIT_RS11980
uniprot id: D3T6X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

580331:THIT RS02885
gene id: 580331:THIT_RS02885
uniprot id: D3T7F0
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS11860
gene id: 580331:THIT_RS11860
uniprot id: D3T6V1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

580331:THIT RS04375
gene id: 580331:THIT_RS04375
uniprot id: D3T868
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS00305
gene id: 580331:THIT_RS00305
uniprot id: D3T582
names: Similarity
messages: Belongs to the glycosyl hydrolase 130 family.

580331:THIT RS03615
gene id: 580331:THIT_RS03615
uniprot id: D3T7S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS11105
gene id: 580331:THIT_RS11105
uniprot id: D3T5Q9
names: Similarity
messages: Belongs to the GerABKC lipoprotein family.

580331:THIT RS07780
gene id: 580331:THIT_RS07780
uniprot id: D3T3K3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

580331:THIT RS07650
gene id: 580331:THIT_RS07650
uniprot id: D3T3I4
names: Subcellular Location Annotation
messages: Cytoplasm

580331:THIT RS09995
gene id: 580331:THIT_RS09995
uniprot id: D3T4T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

580331:THIT RS00505
gene id: 580331:THIT_RS00505
uniprot id: D3T5B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

580331:THIT RS05635
gene id: 580331:THIT_RS05635
uniprot id: D3T8W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

580331:THIT RS00040
gene id: 580331:THIT_RS00040
uniprot id: D3T4R4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

580331:THIT RS08225
gene id: 580331:THIT_RS08225
uniprot id: D3T3U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

580331:THIT RS05285
gene id: 580331:THIT_RS05285
uniprot id: D3T8P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

580331:THIT RS03640
gene id: 580331:THIT_RS03640
uniprot id: D3T7T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

580331:THIT RS00120
gene id: 580331:THIT_RS00120
uniprot id: D3T553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

580331:THIT RS08250
gene id: 580331:THIT_RS08250
uniprot id: D3T3U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

580331:THIT RS05725
gene id: 580331:THIT_RS05725
uniprot id: D3T8Y1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

580331:THIT RS00110
gene id: 580331:THIT_RS00110
uniprot id: D3T551
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

580331:THIT RS06665
gene id: 580331:THIT_RS06665
uniprot id: D3T2Z6
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

580331:THIT RS08435
gene id: 580331:THIT_RS08435
uniprot id: D3T3Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

580331:THIT RS03030
gene id: 580331:THIT_RS03030
uniprot id: D3T7H0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

580331:THIT RS02820
gene id: 580331:THIT_RS02820
uniprot id: D3T7D7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

580331:THIT RS02790
gene id: 580331:THIT_RS02790
uniprot id: D3T7D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

580331:THIT RS05780
gene id: 580331:THIT_RS05780
uniprot id: D3T8Z2
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

580331:THIT RS04550
gene id: 580331:THIT_RS04550
uniprot id: D3T8A3
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS01140
gene id: 580331:THIT_RS01140
uniprot id: D3T617
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddB/RexB type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of AddA and AddB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.

580331:THIT RS08710
gene id: 580331:THIT_RS08710
uniprot id: D3T439
names: Function
names: Similarity
messages: Belongs to the UxaE family.
messages: Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).

580331:THIT RS08025
gene id: 580331:THIT_RS08025
uniprot id: D3T3Q3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10240
gene id: 580331:THIT_RS10240
uniprot id: D3T4X8
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

580331:THIT RS05215
gene id: 580331:THIT_RS05215
uniprot id: D3T8M9
names: Similarity
messages: Belongs to the UPF0473 family.

580331:THIT RS01025
gene id: 580331:THIT_RS01025
uniprot id: D3T5Z5
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

580331:THIT RS08240
gene id: 580331:THIT_RS08240
uniprot id: D3T3U5
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

580331:THIT RS04095
gene id: 580331:THIT_RS04095
uniprot id: D3T814
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS00870
gene id: 580331:THIT_RS00870
uniprot id: D3T5W3
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS01610
gene id: 580331:THIT_RS01610
uniprot id: D3T6M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
messages: Homodimer.
messages: Monomer.
messages: Secreted

580331:THIT RS09185
gene id: 580331:THIT_RS09185
uniprot id: D3T4D0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS08570
gene id: 580331:THIT_RS08570
uniprot id: D3T411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05075
gene id: 580331:THIT_RS05075
uniprot id: D3T8K2
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

580331:THIT RS01070
gene id: 580331:THIT_RS01070
uniprot id: D3T603
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

580331:THIT RS10065
gene id: 580331:THIT_RS10065
uniprot id: D3T4U5
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

580331:THIT RS00195
gene id: 580331:THIT_RS00195
uniprot id: D3T564
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

580331:THIT RS03760
gene id: 580331:THIT_RS03760
uniprot id: D3T7V1
names: Function
names: Similarity
messages: Belongs to the alpha/beta-type SASP family.
messages: SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.

580331:THIT RS08110
gene id: 580331:THIT_RS08110
uniprot id: D3T3R9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

580331:THIT RS09585
gene id: 580331:THIT_RS09585
uniprot id: D3T4K2
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

580331:THIT RS08650
gene id: 580331:THIT_RS08650
uniprot id: D3T427
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the KduI family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.

580331:THIT RS07540
gene id: 580331:THIT_RS07540
uniprot id: D3T3G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

580331:THIT RS06650
gene id: 580331:THIT_RS06650
uniprot id: D3T2Z3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS09890
gene id: 580331:THIT_RS09890
uniprot id: D3T4Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

580331:THIT RS09180
gene id: 580331:THIT_RS09180
uniprot id: D3T4C9
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS08990
gene id: 580331:THIT_RS08990
uniprot id: D3T492
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

580331:THIT RS04055
gene id: 580331:THIT_RS04055
uniprot id: D3T807
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

580331:THIT RS06690
gene id: 580331:THIT_RS06690
uniprot id: D3T301
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

580331:THIT RS09980
gene id: 580331:THIT_RS09980
uniprot id: D3T4S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

580331:THIT RS02645
gene id: 580331:THIT_RS02645
uniprot id: D3T7A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

580331:THIT RS06545
gene id: 580331:THIT_RS06545
uniprot id: D3T2X4
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS11525
gene id: 580331:THIT_RS11525
uniprot id: D3T6C0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS05790
gene id: 580331:THIT_RS05790
uniprot id: D3T8Z4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS09305
gene id: 580331:THIT_RS09305
uniprot id: D3T4F3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

580331:THIT RS07090
gene id: 580331:THIT_RS07090
uniprot id: D3T379
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

580331:THIT RS04405
gene id: 580331:THIT_RS04405
uniprot id: D3T874
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06100
gene id: 580331:THIT_RS06100
uniprot id: D3T2N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

580331:THIT RS04150
gene id: 580331:THIT_RS04150
uniprot id: D3T825
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

580331:THIT RS07380
gene id: 580331:THIT_RS07380
uniprot id: D3T3D6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS01780
gene id: 580331:THIT_RS01780
uniprot id: D3T6Q4
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

580331:THIT RS05110
gene id: 580331:THIT_RS05110
uniprot id: D3T8K9
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

580331:THIT RS08955
gene id: 580331:THIT_RS08955
uniprot id: D3T485
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

580331:THIT RS02705
gene id: 580331:THIT_RS02705
uniprot id: D3T7B4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

580331:THIT RS02580
gene id: 580331:THIT_RS02580
uniprot id: D3T788
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

580331:THIT RS11325
gene id: 580331:THIT_RS11325
uniprot id: D3T683
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

580331:THIT RS04620
gene id: 580331:THIT_RS04620
uniprot id: D3T8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

580331:THIT RS06235
gene id: 580331:THIT_RS06235
uniprot id: D3T2R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

580331:THIT RS02930
gene id: 580331:THIT_RS02930
uniprot id: D3T7F9
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

580331:THIT RS07160
gene id: 580331:THIT_RS07160
uniprot id: D3T393
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

580331:THIT RS08235
gene id: 580331:THIT_RS08235
uniprot id: D3T3U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

580331:THIT RS04280
gene id: 580331:THIT_RS04280
uniprot id: D3T851
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS11040
gene id: 580331:THIT_RS11040
uniprot id: D3T5P6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

580331:THIT RS06225
gene id: 580331:THIT_RS06225
uniprot id: D3T2Q9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS05965
gene id: 580331:THIT_RS05965
uniprot id: D3T2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

580331:THIT RS03790
gene id: 580331:THIT_RS03790
uniprot id: D3T7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS03205
gene id: 580331:THIT_RS03205
uniprot id: D3T7K6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

580331:THIT RS05470
gene id: 580331:THIT_RS05470
uniprot id: D3T8T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

580331:THIT RS11330
gene id: 580331:THIT_RS11330
uniprot id: D3T684
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS06360
gene id: 580331:THIT_RS06360
uniprot id: D3T2T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

580331:THIT RS10085
gene id: 580331:THIT_RS10085
uniprot id: D3T4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

580331:THIT RS04830
gene id: 580331:THIT_RS04830
uniprot id: D3T8F3
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

580331:THIT RS01245
gene id: 580331:THIT_RS01245
uniprot id: D3T638
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS06610
gene id: 580331:THIT_RS06610
uniprot id: D3T2Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS09080
gene id: 580331:THIT_RS09080
uniprot id: D3T4B0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

580331:THIT RS02155
gene id: 580331:THIT_RS02155
uniprot id: D3T708
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06520
gene id: 580331:THIT_RS06520
uniprot id: D3T2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

580331:THIT RS07830
gene id: 580331:THIT_RS07830
uniprot id: D3T3L3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

580331:THIT RS07335
gene id: 580331:THIT_RS07335
uniprot id: D3T3C7
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

580331:THIT RS01505
gene id: 580331:THIT_RS01505
uniprot id: D3T6K1
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

580331:THIT RS05355
gene id: 580331:THIT_RS05355
uniprot id: D3T8Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

580331:THIT RS00890
gene id: 580331:THIT_RS00890
uniprot id: D3T5W7
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

580331:THIT RS09795
gene id: 580331:THIT_RS09795
uniprot id: D3T4N1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

580331:THIT RS00060
gene id: 580331:THIT_RS00060
uniprot id: D3T541
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

580331:THIT RS02945
gene id: 580331:THIT_RS02945
uniprot id: D3T7G2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

580331:THIT RS01120
gene id: 580331:THIT_RS01120
uniprot id: D3T613
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06245
gene id: 580331:THIT_RS06245
uniprot id: D3T2R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

580331:THIT RS02140
gene id: 580331:THIT_RS02140
uniprot id: D3T705
names: Similarity
messages: Belongs to the BMP lipoprotein family.

580331:THIT RS06475
gene id: 580331:THIT_RS06475
uniprot id: D3T2W0
names: Similarity
messages: Belongs to the asp23 family.

580331:THIT RS09785
gene id: 580331:THIT_RS09785
uniprot id: D3T4M9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

580331:THIT RS01180
gene id: 580331:THIT_RS01180
uniprot id: D3T625
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

580331:THIT RS00085
gene id: 580331:THIT_RS00085
uniprot id: D3T546
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS05425
gene id: 580331:THIT_RS05425
uniprot id: D3T8S1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

580331:THIT RS00150
gene id: 580331:THIT_RS00150
uniprot id: D3T558
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

580331:THIT RS07585
gene id: 580331:THIT_RS07585
uniprot id: D3T3H6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

580331:THIT RS03690
gene id: 580331:THIT_RS03690
uniprot id: D3T7U2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

580331:THIT RS03290
gene id: 580331:THIT_RS03290
uniprot id: D3T7M0
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

580331:THIT RS06220
gene id: 580331:THIT_RS06220
uniprot id: D3T2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS06810
gene id: 580331:THIT_RS06810
uniprot id: D3T322
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

580331:THIT RS01165
gene id: 580331:THIT_RS01165
uniprot id: D3T622
names: Similarity
messages: Belongs to the Fur family.

580331:THIT RS05940
gene id: 580331:THIT_RS05940
uniprot id: D3T2K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

580331:THIT RS07570
gene id: 580331:THIT_RS07570
uniprot id: D3T3H3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

580331:THIT RS00185
gene id: 580331:THIT_RS00185
uniprot id: D3T562
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

580331:THIT RS12290
gene id: 580331:THIT_RS12290
uniprot id: D3T4T2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

580331:THIT RS01915
gene id: 580331:THIT_RS01915
uniprot id: D3T6S8
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

580331:THIT RS05810
gene id: 580331:THIT_RS05810
uniprot id: D3T8Z8
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

580331:THIT RS05240
gene id: 580331:THIT_RS05240
uniprot id: D3T8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

580331:THIT RS10245
gene id: 580331:THIT_RS10245
uniprot id: D3T4X9
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

580331:THIT RS04135
gene id: 580331:THIT_RS04135
uniprot id: D3T822
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

580331:THIT RS05705
gene id: 580331:THIT_RS05705
uniprot id: D3T8X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

580331:THIT RS09935
gene id: 580331:THIT_RS09935
uniprot id: D3T4R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

580331:THIT RS00535
gene id: 580331:THIT_RS00535
uniprot id: D3T5C5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS11070
gene id: 580331:THIT_RS11070
uniprot id: D3T5Q2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS02700
gene id: 580331:THIT_RS02700
uniprot id: D3T7B3
names: Similarity
messages: Belongs to the MotB family.

580331:THIT RS06465
gene id: 580331:THIT_RS06465
uniprot id: D3T2V8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

580331:THIT RS01210
gene id: 580331:THIT_RS01210
uniprot id: D3T631
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS04800
gene id: 580331:THIT_RS04800
uniprot id: D3T8E7
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SspI family.
messages: Expressed only in the forespore compartment of sporulating cells.
messages: Spore core

580331:THIT RS11205
gene id: 580331:THIT_RS11205
uniprot id: D3T658
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

580331:THIT RS08015
gene id: 580331:THIT_RS08015
uniprot id: D3T3Q1
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

580331:THIT RS02810
gene id: 580331:THIT_RS02810
uniprot id: D3T7D5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

580331:THIT RS03165
gene id: 580331:THIT_RS03165
uniprot id: D3T7J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

580331:THIT RS05030
gene id: 580331:THIT_RS05030
uniprot id: D3T8J2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

580331:THIT RS02050
gene id: 580331:THIT_RS02050
uniprot id: D3T6Y7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

580331:THIT RS07795
gene id: 580331:THIT_RS07795
uniprot id: D3T3K6
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

580331:THIT RS11310
gene id: 580331:THIT_RS11310
uniprot id: D3T679
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

580331:THIT RS01390
gene id: 580331:THIT_RS01390
uniprot id: D3T6H8
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

580331:THIT RS08645
gene id: 580331:THIT_RS08645
uniprot id: D3T426
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha-galacturonidase able to catalyze the hydrolysis of the chromogenic substrate p-nitrophenyl-alpha-D-galacturonic acid (pNPalphaGalUA). It is probable that alpha-1,4-di-galacturonate (GalUA(2)) is the naturally occurring substrate.
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Homotetramer.

580331:THIT RS08720
gene id: 580331:THIT_RS08720
uniprot id: D3T441
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS00950
gene id: 580331:THIT_RS00950
uniprot id: D3T5Y0
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

580331:THIT RS02055
gene id: 580331:THIT_RS02055
uniprot id: D3T6Y8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

580331:THIT RS00430
gene id: 580331:THIT_RS00430
uniprot id: D3T5A4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

580331:THIT RS08220
gene id: 580331:THIT_RS08220
uniprot id: D3T3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05710
gene id: 580331:THIT_RS05710
uniprot id: D3T8X9
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

580331:THIT RS08140
gene id: 580331:THIT_RS08140
uniprot id: D3T3S5
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06395
gene id: 580331:THIT_RS06395
uniprot id: D3T2U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

580331:THIT RS09640
gene id: 580331:THIT_RS09640
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS02060
gene id: 580331:THIT_RS02060
uniprot id: D3T6Y9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

580331:THIT RS08160
gene id: 580331:THIT_RS08160
uniprot id: D3T3S9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS03935
gene id: 580331:THIT_RS03935
uniprot id: D3T7Y3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

580331:THIT RS01720
gene id: 580331:THIT_RS01720
uniprot id: D3T6P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

580331:THIT RS11285
gene id: 580331:THIT_RS11285
uniprot id: D3T674
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

580331:THIT RS04490
gene id: 580331:THIT_RS04490
uniprot id: D3T892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

580331:THIT RS09850
gene id: 580331:THIT_RS09850
uniprot id: D3T4P2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

580331:THIT RS01730
gene id: 580331:THIT_RS01730
uniprot id: D3T6P4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

580331:THIT RS08450
gene id: 580331:THIT_RS08450
uniprot id: D3T3Y7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

580331:THIT RS03300
gene id: 580331:THIT_RS03300
uniprot id: D3T7M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

580331:THIT RS09590
gene id: 580331:THIT_RS09590
uniprot id: D3T4K3
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

580331:THIT RS09085
gene id: 580331:THIT_RS09085
uniprot id: D3T4B1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

580331:THIT RS06210
gene id: 580331:THIT_RS06210
uniprot id: D3T2Q6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

580331:THIT RS03135
gene id: 580331:THIT_RS03135
uniprot id: D3T7J2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

580331:THIT RS04345
gene id: 580331:THIT_RS04345
uniprot id: D3T864
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

580331:THIT RS11355
gene id: 580331:THIT_RS11355
uniprot id: D3T689
names: Similarity
messages: Belongs to the UPF0735 family.

580331:THIT RS10030
gene id: 580331:THIT_RS10030
uniprot id: D3T4T8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

580331:THIT RS08280
gene id: 580331:THIT_RS08280
uniprot id: D3T3V5
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

580331:THIT RS01145
gene id: 580331:THIT_RS01145
uniprot id: D3T618
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddA subfamily.
messages: Heterodimer of AddA and AddB/RexB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

580331:THIT RS09110
gene id: 580331:THIT_RS09110
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS07555
gene id: 580331:THIT_RS07555
uniprot id: D3T3H0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

580331:THIT RS10250
gene id: 580331:THIT_RS10250
uniprot id: D3T4Y0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS10135
gene id: 580331:THIT_RS10135
uniprot id: D3T4V8
names: Similarity
messages: Belongs to the CtsR family.

580331:THIT RS03815
gene id: 580331:THIT_RS03815
uniprot id: D3T7W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS06570
gene id: 580331:THIT_RS06570
uniprot id: D3T2X9
names: Similarity
messages: Belongs to the RemA family.

580331:THIT RS06015
gene id: 580331:THIT_RS06015
uniprot id: D3T2L9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

580331:THIT RS01015
gene id: 580331:THIT_RS01015
uniprot id: D3T5Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS08045
gene id: 580331:THIT_RS08045
uniprot id: D3T3Q6
names: Similarity
messages: Belongs to the HypD family.

580331:THIT RS02115
gene id: 580331:THIT_RS02115
uniprot id: D3T700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS08860
gene id: 580331:THIT_RS08860
uniprot id: D3T469
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

580331:THIT RS09090
gene id: 580331:THIT_RS09090
uniprot id: D3T4B2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

580331:THIT RS01090
gene id: 580331:THIT_RS01090
uniprot id: D3T607
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

580331:THIT RS11895
gene id: 580331:THIT_RS11895
uniprot id: D3T6V8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

580331:THIT RS01130
gene id: 580331:THIT_RS01130
uniprot id: D3T615
names: Similarity
messages: Belongs to the hemerythrin family.

580331:THIT RS07095
gene id: 580331:THIT_RS07095
uniprot id: D3T380
names: Similarity
messages: Belongs to the TrpF family.

580331:THIT RS06265
gene id: 580331:THIT_RS06265
uniprot id: D3T2R7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

580331:THIT RS03420
gene id: 580331:THIT_RS03420
uniprot id: D3T7P1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

580331:THIT RS06080
gene id: 580331:THIT_RS06080
uniprot id: D3T2N2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

580331:THIT RS02375
gene id: 580331:THIT_RS02375
uniprot id: D3T749
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

580331:THIT RS00425
gene id: 580331:THIT_RS00425
uniprot id: D3T5A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

580331:THIT RS01955
gene id: 580331:THIT_RS01955
uniprot id: D3T6T7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS00045
gene id: 580331:THIT_RS00045
uniprot id: D3T4R5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

580331:THIT RS01445
gene id: 580331:THIT_RS01445
uniprot id: D3T6I9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

580331:THIT RS09130
gene id: 580331:THIT_RS09130
uniprot id: D3T4B9
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS00900
gene id: 580331:THIT_RS00900
uniprot id: D3T5W9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

580331:THIT RS00995
gene id: 580331:THIT_RS00995
uniprot id: D3T5Y9
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

580331:THIT RS03145
gene id: 580331:THIT_RS03145
uniprot id: D3T7J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

580331:THIT RS04480
gene id: 580331:THIT_RS04480
uniprot id: D3T890
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

580331:THIT RS03115
gene id: 580331:THIT_RS03115
uniprot id: D3T7I8
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

580331:THIT RS03105
gene id: 580331:THIT_RS03105
uniprot id: D3T7I6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

580331:THIT RS05955
gene id: 580331:THIT_RS05955
uniprot id: D3T2K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

580331:THIT RS07800
gene id: 580331:THIT_RS07800
uniprot id: D3T3K7
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

580331:THIT RS05060
gene id: 580331:THIT_RS05060
uniprot id: D3T8J8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

580331:THIT RS00885
gene id: 580331:THIT_RS00885
uniprot id: D3T5W6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

580331:THIT RS05640
gene id: 580331:THIT_RS05640
uniprot id: D3T8W5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

580331:THIT RS00615
gene id: 580331:THIT_RS00615
uniprot id: D3T5E1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

580331:THIT RS10445
gene id: 580331:THIT_RS10445
uniprot id: D3T518
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS08995
gene id: 580331:THIT_RS08995
uniprot id: D3T493
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

580331:THIT RS09830
gene id: 580331:THIT_RS09830
uniprot id: D3T4N8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

580331:THIT RS01500
gene id: 580331:THIT_RS01500
uniprot id: D3T6K0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

580331:THIT RS10160
gene id: 580331:THIT_RS10160
uniprot id: D3T4W2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

580331:THIT RS07455
gene id: 580331:THIT_RS07455
uniprot id: D3T3F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

580331:THIT RS01800
gene id: 580331:THIT_RS01800
uniprot id: D3T6Q8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

580331:THIT RS05980
gene id: 580331:THIT_RS05980
uniprot id: D3T2L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

580331:THIT RS07940
gene id: 580331:THIT_RS07940
uniprot id: D3T3N5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

580331:THIT RS04420
gene id: 580331:THIT_RS04420
uniprot id: D3T877
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS09915
gene id: 580331:THIT_RS09915
uniprot id: D3T4Q6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

580331:THIT RS11945
gene id: 580331:THIT_RS11945
uniprot id: D3T6W8
names: Similarity
messages: Belongs to the ParB family.

580331:THIT RS09950
gene id: 580331:THIT_RS09950
uniprot id: D3T4S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

580331:THIT RS02165
gene id: 580331:THIT_RS02165
uniprot id: D3T710
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

580331:THIT RS06585
gene id: 580331:THIT_RS06585
uniprot id: D3T2Y2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS04950
gene id: 580331:THIT_RS04950
uniprot id: D3T8H7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

580331:THIT RS06660
gene id: 580331:THIT_RS06660
uniprot id: D3T2Z5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

580331:THIT RS01125
gene id: 580331:THIT_RS01125
uniprot id: D3T614
names: Similarity
messages: Belongs to the hemerythrin family.

580331:THIT RS02005
gene id: 580331:THIT_RS02005
uniprot id: D3T6U7
names: Function
messages: Involved in the transposition of the insertion sequence.

580331:THIT RS08090
gene id: 580331:THIT_RS08090
uniprot id: D3T3R5
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS08685
gene id: 580331:THIT_RS08685
uniprot id: D3T434
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

580331:THIT RS11905
gene id: 580331:THIT_RS11905
uniprot id: D3T6W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

580331:THIT RS07130
gene id: 580331:THIT_RS07130
uniprot id: D3T387
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

580331:THIT RS06190
gene id: 580331:THIT_RS06190
uniprot id: D3T2Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

580331:THIT RS09775
gene id: 580331:THIT_RS09775
uniprot id: D3T4M7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

580331:THIT RS06090
gene id: 580331:THIT_RS06090
uniprot id: D3T2N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

580331:THIT RS06670
gene id: 580331:THIT_RS06670
uniprot id: D3T2Z7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10715
gene id: 580331:THIT_RS10715
uniprot id: D3T5I3
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

580331:THIT RS08605
gene id: 580331:THIT_RS08605
uniprot id: D3T418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

580331:THIT RS09905
gene id: 580331:THIT_RS09905
uniprot id: D3T4Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

580331:THIT RS04195
gene id: 580331:THIT_RS04195
uniprot id: D3T834
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

580331:THIT RS02760
gene id: 580331:THIT_RS02760
uniprot id: D3T7C5
names: Function
names: Similarity
names: Subunit
messages: Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.
messages: Belongs to the HutP family.
messages: Homohexamer.

580331:THIT RS09025
gene id: 580331:THIT_RS09025
uniprot id: D3T499
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS09215
gene id: 580331:THIT_RS09215
uniprot id: D3T4D5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

580331:THIT RS01510
gene id: 580331:THIT_RS01510
uniprot id: D3T6K2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.
messages: Homotetramer.

580331:THIT RS05890
gene id: 580331:THIT_RS05890
uniprot id: D3T914
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

580331:THIT RS11955
gene id: 580331:THIT_RS11955
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS08665
gene id: 580331:THIT_RS08665
uniprot id: D3T430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS08560
gene id: 580331:THIT_RS08560
uniprot id: D3T409
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

580331:THIT RS00075
gene id: 580331:THIT_RS00075
uniprot id: D3T544
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

580331:THIT RS00655
gene id: 580331:THIT_RS00655
uniprot id: D3T5F0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

580331:THIT RS04625
gene id: 580331:THIT_RS04625
uniprot id: D3T8B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

580331:THIT RS00965
gene id: 580331:THIT_RS00965
uniprot id: D3T5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02175
gene id: 580331:THIT_RS02175
uniprot id: D3T712
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

580331:THIT RS07990
gene id: 580331:THIT_RS07990
uniprot id: D3T3P5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

580331:THIT RS00650
gene id: 580331:THIT_RS00650
uniprot id: D3T5E9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

580331:THIT RS05275
gene id: 580331:THIT_RS05275
uniprot id: D3T8P1
names: Similarity
messages: Belongs to the GSP E family.

580331:THIT RS03110
gene id: 580331:THIT_RS03110
uniprot id: D3T7I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

580331:THIT RS00855
gene id: 580331:THIT_RS00855
uniprot id: D3T5W0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

580331:THIT RS05010
gene id: 580331:THIT_RS05010
uniprot id: D3T8I8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

580331:THIT RS00680
gene id: 580331:THIT_RS00680
uniprot id: D3T5F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

580331:THIT RS09975
gene id: 580331:THIT_RS09975
uniprot id: D3T4S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

580331:THIT RS02540
gene id: 580331:THIT_RS02540
uniprot id: D3T780
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS08020
gene id: 580331:THIT_RS08020
uniprot id: D3T3Q2
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

580331:THIT RS11935
gene id: 580331:THIT_RS11935
uniprot id: D3T6W6
names: Similarity
messages: Belongs to the ParB family.

580331:THIT RS02965
gene id: 580331:THIT_RS02965
uniprot id: D3T7G6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

580331:THIT RS00530
gene id: 580331:THIT_RS00530
uniprot id: D3T5C4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

580331:THIT RS07490
gene id: 580331:THIT_RS07490
uniprot id: D3T3F8
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

580331:THIT RS08470
gene id: 580331:THIT_RS08470
uniprot id: D3T3Z1
names: Similarity
messages: Belongs to the transpeptidase family.

580331:THIT RS11670
gene id: 580331:THIT_RS11670
uniprot id: D3T6E8
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

580331:THIT RS07820
gene id: 580331:THIT_RS07820
uniprot id: D3T3L1
names: Similarity
messages: Belongs to the Fur family.

580331:THIT RS00725
gene id: 580331:THIT_RS00725
uniprot id: D3T5T3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10785
gene id: 580331:THIT_RS10785
uniprot id: D3T5J7
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

580331:THIT RS00705
gene id: 580331:THIT_RS00705
uniprot id: D3T5S9
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS05995
gene id: 580331:THIT_RS05995
uniprot id: D3T2L5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

580331:THIT RS02325
gene id: 580331:THIT_RS02325
uniprot id: D3T739
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

580331:THIT RS03610
gene id: 580331:THIT_RS03610
uniprot id: D3T7S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

580331:THIT RS06165
gene id: 580331:THIT_RS06165
uniprot id: D3T2P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

580331:THIT RS04175
gene id: 580331:THIT_RS04175
uniprot id: D3T830
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS01435
gene id: 580331:THIT_RS01435
uniprot id: D3T6I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

580331:THIT RS08150
gene id: 580331:THIT_RS08150
uniprot id: D3T3S7
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

580331:THIT RS04190
gene id: 580331:THIT_RS04190
uniprot id: D3T833
names: Similarity
messages: Belongs to the transpeptidase family.

580331:THIT RS00450
gene id: 580331:THIT_RS00450
uniprot id: D3T5A8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

580331:THIT RS11690
gene id: 580331:THIT_RS11690
uniprot id: D3T6F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

580331:THIT RS05365
gene id: 580331:THIT_RS05365
uniprot id: D3T8Q9
names: Similarity
messages: Belongs to the peptidase M24B family.

580331:THIT RS10070
gene id: 580331:THIT_RS10070
uniprot id: D3T4U6
names: Similarity
messages: Belongs to the ycf81 family.

580331:THIT RS11795
gene id: 580331:THIT_RS11795
uniprot id: D3T6G8
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

580331:THIT RS10460
gene id: 580331:THIT_RS10460
uniprot id: D3T522
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

580331:THIT RS03445
gene id: 580331:THIT_RS03445
uniprot id: D3T7P6
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

580331:THIT RS10050
gene id: 580331:THIT_RS10050
uniprot id: D3T4U2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS07805
gene id: 580331:THIT_RS07805
uniprot id: D3T3K8
names: Similarity
messages: Belongs to the sigma-54 factor family.

580331:THIT RS09075
gene id: 580331:THIT_RS09075
uniprot id: D3T4A9
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

580331:THIT RS11865
gene id: 580331:THIT_RS11865
uniprot id: D3T6V2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

580331:THIT RS08825
gene id: 580331:THIT_RS08825
uniprot id: D3T462
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

580331:THIT RS07915
gene id: 580331:THIT_RS07915
uniprot id: D3T3N0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

580331:THIT RS05115
gene id: 580331:THIT_RS05115
uniprot id: D3T8L0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS02130
gene id: 580331:THIT_RS02130
uniprot id: D3T703
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS00905
gene id: 580331:THIT_RS00905
uniprot id: D3T5X0
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS07085
gene id: 580331:THIT_RS07085
uniprot id: D3T378
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

580331:THIT RS09010
gene id: 580331:THIT_RS09010
uniprot id: D3T496
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

580331:THIT RS02870
gene id: 580331:THIT_RS02870
uniprot id: D3T7E7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

580331:THIT RS08305
gene id: 580331:THIT_RS08305
uniprot id: D3T3W0
names: Similarity
messages: Belongs to the Fur family.

580331:THIT RS06250
gene id: 580331:THIT_RS06250
uniprot id: D3T2R4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

580331:THIT RS03795
gene id: 580331:THIT_RS03795
uniprot id: D3T7V8
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

580331:THIT RS08230
gene id: 580331:THIT_RS08230
uniprot id: D3T3U3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

580331:THIT RS01775
gene id: 580331:THIT_RS01775
uniprot id: D3T6Q3
names: Similarity
messages: Belongs to the CobH/CbiC family.

580331:THIT RS06135
gene id: 580331:THIT_RS06135
uniprot id: D3T2P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05350
gene id: 580331:THIT_RS05350
uniprot id: D3T8Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

580331:THIT RS11885
gene id: 580331:THIT_RS11885
uniprot id: D3T6V6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

580331:THIT RS07645
gene id: 580331:THIT_RS07645
uniprot id: D3T3I3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

580331:THIT RS05230
gene id: 580331:THIT_RS05230
uniprot id: D3T8N2
names: Similarity
messages: Belongs to the UPF0342 family.

580331:THIT RS03975
gene id: 580331:THIT_RS03975
uniprot id: D3T7Z1
names: Similarity
messages: Belongs to the peptidase S49 family.

580331:THIT RS01450
gene id: 580331:THIT_RS01450
uniprot id: D3T6J0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS00295
gene id: 580331:THIT_RS00295
uniprot id: D3T580
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

580331:THIT RS05590
gene id: 580331:THIT_RS05590
uniprot id: D3T8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

580331:THIT RS07385
gene id: 580331:THIT_RS07385
uniprot id: D3T3D7
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS11175
gene id: 580331:THIT_RS11175
uniprot id: D3T5S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

580331:THIT RS08535
gene id: 580331:THIT_RS08535
uniprot id: D3T404
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS00940
gene id: 580331:THIT_RS00940
uniprot id: D3T5X8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

580331:THIT RS03090
gene id: 580331:THIT_RS03090
uniprot id: D3T7I4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS03075
gene id: 580331:THIT_RS03075
uniprot id: D3T7I0
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS00435
gene id: 580331:THIT_RS00435
uniprot id: D3T5A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

580331:THIT RS11870
gene id: 580331:THIT_RS11870
uniprot id: D3T6V3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

580331:THIT RS04205
gene id: 580331:THIT_RS04205
uniprot id: D3T836
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

580331:THIT RS00130
gene id: 580331:THIT_RS00130
uniprot id: D3T556
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS02970
gene id: 580331:THIT_RS02970
uniprot id: D3T7G7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

580331:THIT RS01550
gene id: 580331:THIT_RS01550
uniprot id: D3T6K9
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

580331:THIT RS09770
gene id: 580331:THIT_RS09770
uniprot id: D3T4M6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

580331:THIT RS04745
gene id: 580331:THIT_RS04745
uniprot id: D3T8D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

580331:THIT RS01870
gene id: 580331:THIT_RS01870
uniprot id: D3T6S2
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS05220
gene id: 580331:THIT_RS05220
uniprot id: D3T8N0
names: Similarity
messages: Belongs to the Fur family.

580331:THIT RS03885
gene id: 580331:THIT_RS03885
uniprot id: D3T7X4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

580331:THIT RS05090
gene id: 580331:THIT_RS05090
uniprot id: D3T8K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

580331:THIT RS01085
gene id: 580331:THIT_RS01085
uniprot id: D3T606
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06655
gene id: 580331:THIT_RS06655
uniprot id: D3T2Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

580331:THIT RS03080
gene id: 580331:THIT_RS03080
uniprot id: D3T7I1
names: Similarity
messages: Belongs to the leucine-binding protein family.

580331:THIT RS09045
gene id: 580331:THIT_RS09045
uniprot id: D3T4A3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS00260
gene id: 580331:THIT_RS00260
uniprot id: D3T572
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

580331:THIT RS00955
gene id: 580331:THIT_RS00955
uniprot id: D3T5Y1
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

580331:THIT RS00190
gene id: 580331:THIT_RS00190
uniprot id: D3T563
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

580331:THIT RS01290
gene id: 580331:THIT_RS01290
uniprot id: D3T646
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

580331:THIT RS01595
gene id: 580331:THIT_RS01595
uniprot id: D3T6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS02730
gene id: 580331:THIT_RS02730
uniprot id: D3T7B9
names: Similarity
messages: Belongs to the asp23 family.

580331:THIT RS09160
gene id: 580331:THIT_RS09160
uniprot id: D3T4C5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

580331:THIT RS07400
gene id: 580331:THIT_RS07400
uniprot id: D3T3E0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

580331:THIT RS03785
gene id: 580331:THIT_RS03785
uniprot id: D3T7V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS05760
gene id: 580331:THIT_RS05760
uniprot id: D3T8Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

580331:THIT RS02865
gene id: 580331:THIT_RS02865
uniprot id: D3T7E6
names: Similarity
messages: Belongs to the GARS family.

580331:THIT RS10040
gene id: 580331:THIT_RS10040
uniprot id: D3T4U0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

580331:THIT RS00510
gene id: 580331:THIT_RS00510
uniprot id: D3T5C0
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS07180
gene id: 580331:THIT_RS07180
uniprot id: D3T397
names: Similarity
messages: Belongs to the YggT family.

580331:THIT RS11160
gene id: 580331:THIT_RS11160
uniprot id: D3T5S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PrsA family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.

580331:THIT RS05055
gene id: 580331:THIT_RS05055
uniprot id: D3T8J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

580331:THIT RS04615
gene id: 580331:THIT_RS04615
uniprot id: D3T8B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

580331:THIT RS03895
gene id: 580331:THIT_RS03895
uniprot id: D3T7X6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS10325
gene id: 580331:THIT_RS10325
uniprot id: D3T4Z5
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

580331:THIT RS05485
gene id: 580331:THIT_RS05485
uniprot id: D3T8T3
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: Cytoplasm
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS00795
gene id: 580331:THIT_RS00795
uniprot id: D3T5U8
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

580331:THIT RS05455
gene id: 580331:THIT_RS05455
uniprot id: D3T8S7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

580331:THIT RS00495
gene id: 580331:THIT_RS00495
uniprot id: D3T5B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

580331:THIT RS09335
gene id: 580331:THIT_RS09335
uniprot id: D3T4F9
names: Similarity
messages: Belongs to the UPF0047 family.

580331:THIT RS09485
gene id: 580331:THIT_RS09485
uniprot id: D3T4I5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

580331:THIT RS06355
gene id: 580331:THIT_RS06355
uniprot id: D3T2T5
names: Similarity
messages: Belongs to the glutamine synthetase family.

580331:THIT RS10750
gene id: 580331:THIT_RS10750
uniprot id: D3T5J0
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

580331:THIT RS07520
gene id: 580331:THIT_RS07520
uniprot id: D3T3G4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

580331:THIT RS09430
gene id: 580331:THIT_RS09430
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS07360
gene id: 580331:THIT_RS07360
uniprot id: D3T3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

580331:THIT RS09895
gene id: 580331:THIT_RS09895
uniprot id: D3T2P6
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS03025
gene id: 580331:THIT_RS03025
uniprot id: D3T7G9
names: Similarity
messages: Belongs to the ThiD family.

580331:THIT RS05180
gene id: 580331:THIT_RS05180
uniprot id: D3T8M1
names: Similarity
messages: Belongs to the thioredoxin family.

580331:THIT RS09870
gene id: 580331:THIT_RS09870
uniprot id: D3T4P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

580331:THIT RS05260
gene id: 580331:THIT_RS05260
uniprot id: D3T8N8
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

580331:THIT RS02855
gene id: 580331:THIT_RS02855
uniprot id: D3T7E4
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS09845
gene id: 580331:THIT_RS09845
uniprot id: D3T4P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

580331:THIT RS08145
gene id: 580331:THIT_RS08145
uniprot id: D3T3S6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

580331:THIT RS11515
gene id: 580331:THIT_RS11515
uniprot id: D3T6B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

580331:THIT RS11635
gene id: 580331:THIT_RS11635
uniprot id: D3T6E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

580331:THIT RS07105
gene id: 580331:THIT_RS07105
uniprot id: D3T382
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS00775
gene id: 580331:THIT_RS00775
uniprot id: D3T5U3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

580331:THIT RS04415
gene id: 580331:THIT_RS04415
uniprot id: D3T876
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

580331:THIT RS07900
gene id: 580331:THIT_RS07900
uniprot id: D3T3M7
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

580331:THIT RS09780
gene id: 580331:THIT_RS09780
uniprot id: D3T4M8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

580331:THIT RS08630
gene id: 580331:THIT_RS08630
uniprot id: D3T423
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

580331:THIT RS02550
gene id: 580331:THIT_RS02550
uniprot id: D3T782
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

580331:THIT RS08515
gene id: 580331:THIT_RS08515
uniprot id: D3T400
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS06550
gene id: 580331:THIT_RS06550
uniprot id: D3T2X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

580331:THIT RS04070
gene id: 580331:THIT_RS04070
uniprot id: D3T810
names: Similarity
messages: Belongs to the NadC/ModD family.

580331:THIT RS02345
gene id: 580331:THIT_RS02345
uniprot id: D3T743
names: Similarity
messages: Belongs to the FlgM family.

580331:THIT RS11470
gene id: 580331:THIT_RS11470
uniprot id: D3T6A8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

580331:THIT RS06820
gene id: 580331:THIT_RS06820
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS02105
gene id: 580331:THIT_RS02105
uniprot id: D3T6Z8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

580331:THIT RS06495
gene id: 580331:THIT_RS06495
uniprot id: D3T2W4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

580331:THIT RS03285
gene id: 580331:THIT_RS03285
uniprot id: D3T7L9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

580331:THIT RS09985
gene id: 580331:THIT_RS09985
uniprot id: D3T4S9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

580331:THIT RS00625
gene id: 580331:THIT_RS00625
uniprot id: D3T5E3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

580331:THIT RS04535
gene id: 580331:THIT_RS04535
uniprot id: D3T8A0
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS02665
gene id: 580331:THIT_RS02665
uniprot id: D3T7A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

580331:THIT RS01415
gene id: 580331:THIT_RS01415
uniprot id: D3T6I3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

580331:THIT RS06255
gene id: 580331:THIT_RS06255
uniprot id: D3T2R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

580331:THIT RS00915
gene id: 580331:THIT_RS00915
uniprot id: D3T5X3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

580331:THIT RS10540
gene id: 580331:THIT_RS10540
uniprot id: D3T535
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

580331:THIT RS05830
gene id: 580331:THIT_RS05830
uniprot id: D3T902
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

580331:THIT RS10345
gene id: 580331:THIT_RS10345
uniprot id: D3T4Z9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

580331:THIT RS11995
gene id: 580331:THIT_RS11995
uniprot id: D3T6X8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

580331:THIT RS05785
gene id: 580331:THIT_RS05785
uniprot id: D3T8Z3
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

580331:THIT RS02835
gene id: 580331:THIT_RS02835
uniprot id: D3T7E0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

580331:THIT RS09445
gene id: 580331:THIT_RS09445
uniprot id: D3T4H9
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS03305
gene id: 580331:THIT_RS03305
uniprot id: D3T7M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

580331:THIT RS00635
gene id: 580331:THIT_RS00635
uniprot id: D3T5E5
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS06170
gene id: 580331:THIT_RS06170
uniprot id: D3T2P8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

580331:THIT RS00975
gene id: 580331:THIT_RS00975
uniprot id: D3T5Y5
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

580331:THIT RS05535
gene id: 580331:THIT_RS05535
uniprot id: D3T8U4
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

580331:THIT RS09930
gene id: 580331:THIT_RS09930
uniprot id: D3T4R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

580331:THIT RS09880
gene id: 580331:THIT_RS09880
uniprot id: D3T4P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

580331:THIT RS06785
gene id: 580331:THIT_RS06785
uniprot id: D3T318
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

580331:THIT RS00665
gene id: 580331:THIT_RS00665
uniprot id: D3T5F2
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

580331:THIT RS02355
gene id: 580331:THIT_RS02355
uniprot id: D3T745
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

580331:THIT RS08060
gene id: 580331:THIT_RS08060
uniprot id: D3T3Q9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

580331:THIT RS10340
gene id: 580331:THIT_RS10340
uniprot id: D3T4Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

580331:THIT RS04200
gene id: 580331:THIT_RS04200
uniprot id: D3T835
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

580331:THIT RS02935
gene id: 580331:THIT_RS02935
uniprot id: D3T7G0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

580331:THIT RS03670
gene id: 580331:THIT_RS03670
uniprot id: D3T7T8
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS11135
gene id: 580331:THIT_RS11135
uniprot id: D3T5R5
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

580331:THIT RS11970
gene id: 580331:THIT_RS11970
uniprot id: D3T6X3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS05750
gene id: 580331:THIT_RS05750
uniprot id: D3T8Y6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

580331:THIT RS11025
gene id: 580331:THIT_RS11025
uniprot id: D3T5P3
names: Similarity
messages: Belongs to the peptidase C40 family.

580331:THIT RS06805
gene id: 580331:THIT_RS06805
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS08420
gene id: 580331:THIT_RS08420
uniprot id: D3T3Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

580331:THIT RS05770
gene id: 580331:THIT_RS05770
uniprot id: D3T8Z0
names: Function
names: Similarity
messages: Belongs to the 'phage' integrase family.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

580331:THIT RS02795
gene id: 580331:THIT_RS02795
uniprot id: D3T7D3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

580331:THIT RS00470
gene id: 580331:THIT_RS00470
uniprot id: D3T5B2
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

580331:THIT RS11625
gene id: 580331:THIT_RS11625
uniprot id: D3T6D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

580331:THIT RS07865
gene id: 580331:THIT_RS07865
uniprot id: D3T3M0
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

580331:THIT RS06180
gene id: 580331:THIT_RS06180
uniprot id: D3T2Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

580331:THIT RS07240
gene id: 580331:THIT_RS07240
uniprot id: D3T3A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

580331:THIT RS01045
gene id: 580331:THIT_RS01045
uniprot id: D3T5Z9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS08170
gene id: 580331:THIT_RS08170
uniprot id: D3T3T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

580331:THIT RS02370
gene id: 580331:THIT_RS02370
uniprot id: D3T748
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

580331:THIT RS10925
gene id: 580331:THIT_RS10925
uniprot id: D3T5M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

580331:THIT RS06480
gene id: 580331:THIT_RS06480
uniprot id: D3T2W1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

580331:THIT RS07345
gene id: 580331:THIT_RS07345
uniprot id: D3T3C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U4 family.
messages: Cell membrane
messages: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.

580331:THIT RS10875
gene id: 580331:THIT_RS10875
uniprot id: D3T5L3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

580331:THIT RS01160
gene id: 580331:THIT_RS01160
uniprot id: D3T621
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

580331:THIT RS03130
gene id: 580331:THIT_RS03130
uniprot id: D3T7J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

580331:THIT RS04930
gene id: 580331:THIT_RS04930
uniprot id: D3T8H3
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS04580
gene id: 580331:THIT_RS04580
uniprot id: D3T8A8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

580331:THIT RS06205
gene id: 580331:THIT_RS06205
uniprot id: D3T2Q5
names: Similarity
messages: Belongs to the DprA/Smf family.

580331:THIT RS04515
gene id: 580331:THIT_RS04515
uniprot id: D3T897
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

580331:THIT RS10335
gene id: 580331:THIT_RS10335
uniprot id: D3T4Z7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

580331:THIT RS07715
gene id: 580331:THIT_RS07715
uniprot id: D3T3J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

580331:THIT RS00280
gene id: 580331:THIT_RS00280
uniprot id: D3T576
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS06380
gene id: 580331:THIT_RS06380
uniprot id: D3T2U1
names: Similarity
messages: Belongs to the fabD family.

580331:THIT RS04925
gene id: 580331:THIT_RS04925
uniprot id: D3T8H2
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

580331:THIT RS02490
gene id: 580331:THIT_RS02490
uniprot id: D3T772
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS02845
gene id: 580331:THIT_RS02845
uniprot id: D3T7E2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

580331:THIT RS06680
gene id: 580331:THIT_RS06680
uniprot id: D3T2Z9
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

580331:THIT RS00360
gene id: 580331:THIT_RS00360
uniprot id: D3T593
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

580331:THIT RS06420
gene id: 580331:THIT_RS06420
uniprot id: D3T2U9
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

580331:THIT RS09865
gene id: 580331:THIT_RS09865
uniprot id: D3T4P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

580331:THIT RS04475
gene id: 580331:THIT_RS04475
uniprot id: D3T889
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

580331:THIT RS07765
gene id: 580331:THIT_RS07765
uniprot id: D3T3K0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

580331:THIT RS05900
gene id: 580331:THIT_RS05900
uniprot id: D3T916
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

580331:THIT RS05280
gene id: 580331:THIT_RS05280
uniprot id: D3T8P2
names: Similarity
messages: Belongs to the GSP E family.

580331:THIT RS07325
gene id: 580331:THIT_RS07325
uniprot id: D3T3C5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

580331:THIT RS08055
gene id: 580331:THIT_RS08055
uniprot id: D3T3Q8
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Belongs to the carbamoyltransferase HypF family.

580331:THIT RS03630
gene id: 580331:THIT_RS03630
uniprot id: D3T7T2
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS02525
gene id: 580331:THIT_RS02525
uniprot id: D3T777
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

580331:THIT RS08290
gene id: 580331:THIT_RS08290
uniprot id: D3T3V7
names: Similarity
messages: Belongs to the UPF0251 family.

580331:THIT RS10565
gene id: 580331:THIT_RS10565
uniprot id: D3T5F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS06345
gene id: 580331:THIT_RS06345
uniprot id: D3T2T3
names: Similarity
messages: Belongs to the P(II) protein family.

580331:THIT RS05990
gene id: 580331:THIT_RS05990
uniprot id: D3T2L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

580331:THIT RS05765
gene id: 580331:THIT_RS05765
uniprot id: D3T8Y9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

580331:THIT RS01630
gene id: 580331:THIT_RS01630
uniprot id: D3T6M5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

580331:THIT RS09170
gene id: 580331:THIT_RS09170
uniprot id: D3T4C7
names: Similarity
messages: Belongs to the peptidase M20A family.

580331:THIT RS06070
gene id: 580331:THIT_RS06070
uniprot id: D3T2N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

580331:THIT RS03940
gene id: 580331:THIT_RS03940
uniprot id: D3T7Y4
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

580331:THIT RS11600
gene id: 580331:THIT_RS11600
uniprot id: D3T6D3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

580331:THIT RS01620
gene id: 580331:THIT_RS01620
uniprot id: D3T6M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

580331:THIT RS11210
gene id: 580331:THIT_RS11210
uniprot id: D3T659
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

580331:THIT RS02435
gene id: 580331:THIT_RS02435
uniprot id: D3T761
names: Function
names: Similarity
messages: A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.
messages: Belongs to the DpnII type II restriction endonuclease family.

580331:THIT RS05935
gene id: 580331:THIT_RS05935
uniprot id: D3T923
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

580331:THIT RS02660
gene id: 580331:THIT_RS02660
uniprot id: D3T7A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

580331:THIT RS01455
gene id: 580331:THIT_RS01455
uniprot id: D3T6J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

580331:THIT RS11710
gene id: 580331:THIT_RS11710
uniprot id: D3T6F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

580331:THIT RS00645
gene id: 580331:THIT_RS00645
uniprot id: D3T5E8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS06615
gene id: 580331:THIT_RS06615
uniprot id: D3T2Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

580331:THIT RS08125
gene id: 580331:THIT_RS08125
uniprot id: D3T3S2
names: Similarity
messages: Belongs to the ABC transporter superfamily.

580331:THIT RS04285
gene id: 580331:THIT_RS04285
uniprot id: D3T852
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

580331:THIT RS04560
gene id: 580331:THIT_RS04560
uniprot id: D3T8A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

580331:THIT RS04500
gene id: 580331:THIT_RS04500
uniprot id: D3T894
names: Similarity
messages: Belongs to the UPF0237 family.

580331:THIT RS05160
gene id: 580331:THIT_RS05160
uniprot id: D3T8L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

580331:THIT RS09605
gene id: 580331:THIT_RS09605
uniprot id: D3T4K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Probably a homodimer.

580331:THIT RS07185
gene id: 580331:THIT_RS07185
uniprot id: D3T398
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

580331:THIT RS00200
gene id: 580331:THIT_RS00200
uniprot id: D3T565
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

580331:THIT RS06330
gene id: 580331:THIT_RS06330
uniprot id: D3T2T0
names: Similarity
messages: Belongs to the glutamate synthase family.

580331:THIT RS07775
gene id: 580331:THIT_RS07775
uniprot id: D3T3K2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

580331:THIT RS09760
gene id: 580331:THIT_RS09760
uniprot id: D3T4M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

580331:THIT RS07290
gene id: 580331:THIT_RS07290
uniprot id: D3T3B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

580331:THIT RS03810
gene id: 580331:THIT_RS03810
uniprot id: D3T7W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS00560
gene id: 580331:THIT_RS00560
uniprot id: D3T321
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

580331:THIT RS04215
gene id: 580331:THIT_RS04215
uniprot id: D3T838
names: Caution
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS02460
gene id: 580331:THIT_RS02460
uniprot id: D3T766
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

580331:THIT RS07320
gene id: 580331:THIT_RS07320
uniprot id: D3T3C4
names: Function
messages: May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.

580331:THIT RS00005
gene id: 580331:THIT_RS00005
uniprot id: D3T4Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

580331:THIT RS09745
gene id: 580331:THIT_RS09745
uniprot id: D3T4M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

580331:THIT RS08575
gene id: 580331:THIT_RS08575
uniprot id: D3T412
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

580331:THIT RS07405
gene id: 580331:THIT_RS07405
uniprot id: D3T3E1
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

580331:THIT RS06175
gene id: 580331:THIT_RS06175
uniprot id: D3T2P9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

580331:THIT RS06405
gene id: 580331:THIT_RS06405
uniprot id: D3T2U6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

580331:THIT RS01535
gene id: 580331:THIT_RS01535
uniprot id: D3T6K6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.

580331:THIT RS10920
gene id: 580331:THIT_RS10920
uniprot id: D3T5M1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

580331:THIT RS04610
gene id: 580331:THIT_RS04610
uniprot id: D3T8B4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

580331:THIT RS00600
gene id: 580331:THIT_RS00600
uniprot id: D3T5D8
names: Similarity
messages: Belongs to the AAA ATPase family.
messages: In the C-terminal section; belongs to the peptidase M41 family.

580331:THIT RS02910
gene id: 580331:THIT_RS02910
uniprot id: D3T7F5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

580331:THIT RS11015
gene id: 580331:THIT_RS11015
uniprot id: D3T5P1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

580331:THIT RS07390
gene id: 580331:THIT_RS07390
uniprot id: D3T3D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

580331:THIT RS05440
gene id: 580331:THIT_RS05440
uniprot id: D3T8S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

580331:THIT RS09070
gene id: 580331:THIT_RS09070
uniprot id: D3T4A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

580331:THIT RS05505
gene id: 580331:THIT_RS05505
uniprot id: D3T8T7
names: Subcellular Location Annotation
messages: Membrane

580331:THIT RS10905
gene id: 580331:THIT_RS10905
uniprot id: D3T5L8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

580331:THIT RS07120
gene id: 580331:THIT_RS07120
uniprot id: D3T385
names: Similarity
messages: Belongs to the UPF0045 family.

580331:THIT RS02080
gene id: 580331:THIT_RS02080
uniprot id: D3T6Z3
names: Function
names: Similarity
messages: Belongs to the transposase 11 family.
messages: Involved in the transposition of the insertion sequence IS5.

580331:THIT RS05850
gene id: 580331:THIT_RS05850
uniprot id: D3T906
names: Similarity
messages: Belongs to the peptidase S14 family.

580331:THIT RS11985
gene id: 580331:THIT_RS11985
uniprot id: D3T6X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

580331:THIT RS06140
gene id: 580331:THIT_RS06140
uniprot id: D3T2P4
names: Subcellular Location Annotation
messages: Cytoplasm

580331:THIT RS11385
gene id: 580331:THIT_RS11385
uniprot id: D3T695
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

580331:THIT RS00035
gene id: 580331:THIT_RS00035
uniprot id: D3T4R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.