579137:METVU RS05225
gene id: 579137:METVU_RS05225
uniprot id: C9RH76
names: Similarity
messages: Belongs to the HypE family.

579137:METVU RS04925
gene id: 579137:METVU_RS04925
uniprot id: C9RH14
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

579137:METVU RS02635
gene id: 579137:METVU_RS02635
uniprot id: C9RFP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

579137:METVU RS07205
gene id: 579137:METVU_RS07205
uniprot id: C9RIB9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

579137:METVU RS05995
gene id: 579137:METVU_RS05995
uniprot id: C9RHM7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

579137:METVU RS07965
gene id: 579137:METVU_RS07965
uniprot id: C9RDT3
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

579137:METVU RS00725
gene id: 579137:METVU_RS00725
uniprot id: C9REL3
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

579137:METVU RS03560
gene id: 579137:METVU_RS03560
uniprot id: C9RG81
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

579137:METVU RS04385
gene id: 579137:METVU_RS04385
uniprot id: C9RGQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

579137:METVU RS01100
gene id: 579137:METVU_RS01100
uniprot id: C9RET7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS01885
gene id: 579137:METVU_RS01885
uniprot id: C9RF93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

579137:METVU RS00445
gene id: 579137:METVU_RS00445
uniprot id: C9REF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

579137:METVU RS05850
gene id: 579137:METVU_RS05850
uniprot id: C9RHJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

579137:METVU RS03135
gene id: 579137:METVU_RS03135
uniprot id: C9RFZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

579137:METVU RS02000
gene id: 579137:METVU_RS02000
uniprot id: C9RFB4
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

579137:METVU RS00715
gene id: 579137:METVU_RS00715
uniprot id: C9REL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

579137:METVU RS04230
gene id: 579137:METVU_RS04230
uniprot id: C9RGM0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS00730
gene id: 579137:METVU_RS00730
uniprot id: C9REL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

579137:METVU RS01810
gene id: 579137:METVU_RS01810
uniprot id: C9RF79
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

579137:METVU RS03725
gene id: 579137:METVU_RS03725
uniprot id: C9RGB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

579137:METVU RS06630
gene id: 579137:METVU_RS06630
uniprot id: C9RI00
names: Subunit
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

579137:METVU RS03840
gene id: 579137:METVU_RS03840
uniprot id: C9RGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

579137:METVU RS01040
gene id: 579137:METVU_RS01040
uniprot id: C9RES5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS00985
gene id: 579137:METVU_RS00985
uniprot id: C9RER4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

579137:METVU RS03155
gene id: 579137:METVU_RS03155
uniprot id: C9RG03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

579137:METVU RS04245
gene id: 579137:METVU_RS04245
uniprot id: C9RGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

579137:METVU RS07890
gene id: 579137:METVU_RS07890
uniprot id: C9RDR7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS00265
gene id: 579137:METVU_RS00265
uniprot id: C9REC2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

579137:METVU RS06795
gene id: 579137:METVU_RS06795
uniprot id: C9RI38
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04095
gene id: 579137:METVU_RS04095
uniprot id: C9RGJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

579137:METVU RS04100
gene id: 579137:METVU_RS04100
uniprot id: C9RGJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

579137:METVU RS01155
gene id: 579137:METVU_RS01155
uniprot id: C9REU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

579137:METVU RS03330
gene id: 579137:METVU_RS03330
uniprot id: C9RG35
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS08495
gene id: 579137:METVU_RS08495
uniprot id: C9RE34
names: Similarity
messages: Belongs to the UPF0280 family.

579137:METVU RS07030
gene id: 579137:METVU_RS07030
uniprot id: C9RI85
names: Similarity
messages: Belongs to the MEMO1 family.

579137:METVU RS06610
gene id: 579137:METVU_RS06610
uniprot id: C9RHZ6
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

579137:METVU RS01880
gene id: 579137:METVU_RS01880
uniprot id: C9RF92
names: Similarity
messages: Belongs to the HypD family.

579137:METVU RS05990
gene id: 579137:METVU_RS05990
uniprot id: C9RHM6
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

579137:METVU RS01205
gene id: 579137:METVU_RS01205
uniprot id: C9REV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

579137:METVU RS02565
gene id: 579137:METVU_RS02565
uniprot id: C9RFM7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

579137:METVU RS05855
gene id: 579137:METVU_RS05855
uniprot id: C9RHK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

579137:METVU RS07245
gene id: 579137:METVU_RS07245
uniprot id: C9RIC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

579137:METVU RS08415
gene id: 579137:METVU_RS08415
uniprot id: C9RE18
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

579137:METVU RS00550
gene id: 579137:METVU_RS00550
uniprot id: C9REH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

579137:METVU RS02020
gene id: 579137:METVU_RS02020
uniprot id: C9RFB8
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

579137:METVU RS06385
gene id: 579137:METVU_RS06385
uniprot id: C9RHV4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

579137:METVU RS03980
gene id: 579137:METVU_RS03980
uniprot id: C9RGH0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

579137:METVU RS03075
gene id: 579137:METVU_RS03075
uniprot id: C9RFY7
names: Similarity
messages: Belongs to the FrhG family.

579137:METVU RS08585
gene id: 579137:METVU_RS08585
uniprot id: C9RE51
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS06490
gene id: 579137:METVU_RS06490
uniprot id: C9RHX5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

579137:METVU RS05555
gene id: 579137:METVU_RS05555
uniprot id: C9RHE2
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS00280
gene id: 579137:METVU_RS00280
uniprot id: C9REC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

579137:METVU RS07285
gene id: 579137:METVU_RS07285
uniprot id: C9RID4
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

579137:METVU RS03290
gene id: 579137:METVU_RS03290
uniprot id: C9RG28
names: Similarity
messages: Belongs to the UPF0179 family.

579137:METVU RS02015
gene id: 579137:METVU_RS02015
uniprot id: C9RFB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

579137:METVU RS07875
gene id: 579137:METVU_RS07875
uniprot id: C9RDR4
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

579137:METVU RS01480
gene id: 579137:METVU_RS01480
uniprot id: C9RF15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

579137:METVU RS06145
gene id: 579137:METVU_RS06145
uniprot id: C9RHQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

579137:METVU RS07075
gene id: 579137:METVU_RS07075
uniprot id: C9RI93
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

579137:METVU RS02205
gene id: 579137:METVU_RS02205
uniprot id: C9RFF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the hemerythrin family.
messages: Monomer.
messages: Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen-binding site contains two iron atoms.

579137:METVU RS06740
gene id: 579137:METVU_RS06740
uniprot id: C9RI23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

579137:METVU RS07415
gene id: 579137:METVU_RS07415
uniprot id: C9RIF9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS07250
gene id: 579137:METVU_RS07250
uniprot id: C9RIC6
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS00425
gene id: 579137:METVU_RS00425
uniprot id: C9REF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

579137:METVU RS01785
gene id: 579137:METVU_RS01785
uniprot id: C9RF74
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

579137:METVU RS06770
gene id: 579137:METVU_RS06770
uniprot id: C9RI31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS08195
gene id: 579137:METVU_RS08195
uniprot id: C9RDX6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

579137:METVU RS01380
gene id: 579137:METVU_RS01380
uniprot id: C9REZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04480
gene id: 579137:METVU_RS04480
uniprot id: C9RGS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

579137:METVU RS02955
gene id: 579137:METVU_RS02955
uniprot id: C9RFW2
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

579137:METVU RS07535
gene id: 579137:METVU_RS07535
uniprot id: C9RDK6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

579137:METVU RS01110
gene id: 579137:METVU_RS01110
uniprot id: C9RET9
names: Similarity
messages: Belongs to the SUI1 family.

579137:METVU RS04510
gene id: 579137:METVU_RS04510
uniprot id: C9RGS9
names: Similarity
messages: Belongs to the TPP enzyme family.

579137:METVU RS05890
gene id: 579137:METVU_RS05890
uniprot id: C9RHK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

579137:METVU RS06935
gene id: 579137:METVU_RS06935
uniprot id: C9RI66
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04030
gene id: 579137:METVU_RS04030
uniprot id: C9RGI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

579137:METVU RS01820
gene id: 579137:METVU_RS01820
uniprot id: C9RF81
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

579137:METVU RS03265
gene id: 579137:METVU_RS03265
uniprot id: C9RG23
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS00870
gene id: 579137:METVU_RS00870
uniprot id: C9REP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

579137:METVU RS00830
gene id: 579137:METVU_RS00830
uniprot id: C9REN3
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

579137:METVU RS05170
gene id: 579137:METVU_RS05170
uniprot id: C9RH64
names: Similarity
messages: Belongs to the peptidase S49 family.

579137:METVU RS07085
gene id: 579137:METVU_RS07085
uniprot id: C9RI95
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

579137:METVU RS06275
gene id: 579137:METVU_RS06275
uniprot id: C9RHT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

579137:METVU RS01045
gene id: 579137:METVU_RS01045
uniprot id: C9RES6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

579137:METVU RS00005
gene id: 579137:METVU_RS00005
uniprot id: C9RE72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

579137:METVU RS06560
gene id: 579137:METVU_RS06560
uniprot id: C9RHY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

579137:METVU RS02010
gene id: 579137:METVU_RS02010
uniprot id: C9RFB6
names: Function
messages: Part of a potassium transport system.

579137:METVU RS05295
gene id: 579137:METVU_RS05295
uniprot id: C9RH90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

579137:METVU RS07555
gene id: 579137:METVU_RS07555
uniprot id: C9RDL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

579137:METVU RS01835
gene id: 579137:METVU_RS01835
uniprot id: C9RF84
names: Similarity
messages: Belongs to the UPF0147 family.

579137:METVU RS06010
gene id: 579137:METVU_RS06010
uniprot id: C9RHN0
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

579137:METVU RS07950
gene id: 579137:METVU_RS07950
uniprot id: C9RDT0
names: Similarity
messages: Belongs to the archaeal ATPase family.

579137:METVU RS02615
gene id: 579137:METVU_RS02615
uniprot id: C9RFN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

579137:METVU RS02380
gene id: 579137:METVU_RS02380
uniprot id: C9RFJ0
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04750
gene id: 579137:METVU_RS04750
uniprot id: C9RGX9
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

579137:METVU RS00615
gene id: 579137:METVU_RS00615
uniprot id: C9REJ2
names: Similarity
messages: Belongs to the band 7/mec-2 family.

579137:METVU RS04775
gene id: 579137:METVU_RS04775
uniprot id: C9RGY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

579137:METVU RS05865
gene id: 579137:METVU_RS05865
uniprot id: C9RHK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

579137:METVU RS01190
gene id: 579137:METVU_RS01190
uniprot id: C9REV5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

579137:METVU RS07975
gene id: 579137:METVU_RS07975
uniprot id: C9RDT5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

579137:METVU RS01695
gene id: 579137:METVU_RS01695
uniprot id: C9RF56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

579137:METVU RS01125
gene id: 579137:METVU_RS01125
uniprot id: C9REU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

579137:METVU RS07235
gene id: 579137:METVU_RS07235
uniprot id: C9RIC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

579137:METVU RS08135
gene id: 579137:METVU_RS08135
uniprot id: C9RDW4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

579137:METVU RS01640
gene id: 579137:METVU_RS01640
uniprot id: C9RF49
names: Similarity
messages: Belongs to the archaeal ATPase family.

579137:METVU RS00010
gene id: 579137:METVU_RS00010
uniprot id: C9RE73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

579137:METVU RS03620
gene id: 579137:METVU_RS03620
uniprot id: C9RG93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

579137:METVU RS07530
gene id: 579137:METVU_RS07530
uniprot id: C9RDK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

579137:METVU RS06925
gene id: 579137:METVU_RS06925
uniprot id: C9RI64
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

579137:METVU RS01085
gene id: 579137:METVU_RS01085
uniprot id: C9RET4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

579137:METVU RS01080
gene id: 579137:METVU_RS01080
uniprot id: C9RET3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

579137:METVU RS05590
gene id: 579137:METVU_RS05590
uniprot id: C9RHE9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS05155
gene id: 579137:METVU_RS05155
uniprot id: C9RH61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

579137:METVU RS00750
gene id: 579137:METVU_RS00750
uniprot id: C9REL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS01375
gene id: 579137:METVU_RS01375
uniprot id: C9REZ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

579137:METVU RS08505
gene id: 579137:METVU_RS08505
uniprot id: C9RE36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

579137:METVU RS03000
gene id: 579137:METVU_RS03000
uniprot id: C9RFX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

579137:METVU RS08100
gene id: 579137:METVU_RS08100
uniprot id: C9RDV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

579137:METVU RS08510
gene id: 579137:METVU_RS08510
uniprot id: C9RE37
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

579137:METVU RS06365
gene id: 579137:METVU_RS06365
uniprot id: C9RHV0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

579137:METVU RS02495
gene id: 579137:METVU_RS02495
uniprot id: C9RFL3
names: Similarity
messages: Belongs to the UPF0252 family.

579137:METVU RS03820
gene id: 579137:METVU_RS03820
uniprot id: C9RGD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

579137:METVU RS05615
gene id: 579137:METVU_RS05615
uniprot id: C9RHF4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

579137:METVU RS07580
gene id: 579137:METVU_RS07580
uniprot id: C9RDL5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04115
gene id: 579137:METVU_RS04115
uniprot id: C9RGJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

579137:METVU RS00850
gene id: 579137:METVU_RS00850
uniprot id: C9REN7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

579137:METVU RS00935
gene id: 579137:METVU_RS00935
uniprot id: C9REQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

579137:METVU RS07725
gene id: 579137:METVU_RS07725
uniprot id: C9RDN3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

579137:METVU RS04805
gene id: 579137:METVU_RS04805
uniprot id: C9RGZ0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

579137:METVU RS07755
gene id: 579137:METVU_RS07755
uniprot id: C9RDN9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS01185
gene id: 579137:METVU_RS01185
uniprot id: C9REV4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

579137:METVU RS06000
gene id: 579137:METVU_RS06000
uniprot id: C9RHM8
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

579137:METVU RS05235
gene id: 579137:METVU_RS05235
uniprot id: C9RH78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

579137:METVU RS07840
gene id: 579137:METVU_RS07840
uniprot id: C9RDQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

579137:METVU RS01490
gene id: 579137:METVU_RS01490
uniprot id: C9RF17
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

579137:METVU RS05810
gene id: 579137:METVU_RS05810
uniprot id: C9RHJ1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

579137:METVU RS04615
gene id: 579137:METVU_RS04615
uniprot id: C9RGV1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

579137:METVU RS08795
gene id: 579137:METVU_RS08795
uniprot id: C9RIH8
names: Similarity
messages: Belongs to the MCM family.

579137:METVU RS01905
gene id: 579137:METVU_RS01905
uniprot id: C9RF97
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

579137:METVU RS08650
gene id: 579137:METVU_RS08650
uniprot id: C9RE63
names: Similarity
messages: Belongs to the GARS family.

579137:METVU RS01385
gene id: 579137:METVU_RS01385
uniprot id: C9REZ5
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

579137:METVU RS03665
gene id: 579137:METVU_RS03665
uniprot id: C9RGA2
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS05655
gene id: 579137:METVU_RS05655
uniprot id: C9RHG2
names: Similarity
messages: Belongs to the UPF0237 family.

579137:METVU RS08200
gene id: 579137:METVU_RS08200
uniprot id: C9RDX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

579137:METVU RS02705
gene id: 579137:METVU_RS02705
uniprot id: C9RFQ6
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

579137:METVU RS02405
gene id: 579137:METVU_RS02405
uniprot id: C9RFJ5
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

579137:METVU RS01700
gene id: 579137:METVU_RS01700
uniprot id: C9RF57
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

579137:METVU RS04845
gene id: 579137:METVU_RS04845
uniprot id: C9RGZ8
names: Similarity
messages: Belongs to the archaeal ATPase family.

579137:METVU RS00920
gene id: 579137:METVU_RS00920
uniprot id: C9REQ1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

579137:METVU RS06910
gene id: 579137:METVU_RS06910
uniprot id: C9RI61
names: Similarity
messages: Belongs to the UDPGP type 2 family.

579137:METVU RS03700
gene id: 579137:METVU_RS03700
uniprot id: C9RGA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS07190
gene id: 579137:METVU_RS07190
uniprot id: C9RIB6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS07985
gene id: 579137:METVU_RS07985
uniprot id: C9RDT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

579137:METVU RS02075
gene id: 579137:METVU_RS02075
uniprot id: C9RFC8
names: Similarity
messages: Belongs to the UPF0200 family.

579137:METVU RS05380
gene id: 579137:METVU_RS05380
uniprot id: C9RHA7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

579137:METVU RS00820
gene id: 579137:METVU_RS00820
uniprot id: C9REN1
names: Similarity
messages: Belongs to the UPF0045 family.

579137:METVU RS07955
gene id: 579137:METVU_RS07955
uniprot id: C9RDT1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

579137:METVU RS06510
gene id: 579137:METVU_RS06510
uniprot id: C9RHX9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

579137:METVU RS06090
gene id: 579137:METVU_RS06090
uniprot id: C9RHP6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

579137:METVU RS03800
gene id: 579137:METVU_RS03800
uniprot id: C9RGD3
names: Similarity
messages: Belongs to the peptidase C56 family.

579137:METVU RS01750
gene id: 579137:METVU_RS01750
uniprot id: C9RF66
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

579137:METVU RS08250
gene id: 579137:METVU_RS08250
uniprot id: C9RDY7
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

579137:METVU RS06190
gene id: 579137:METVU_RS06190
uniprot id: C9RHR5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

579137:METVU RS01115
gene id: 579137:METVU_RS01115
uniprot id: C9REU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

579137:METVU RS03310
gene id: 579137:METVU_RS03310
uniprot id: C9RG32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

579137:METVU RS07915
gene id: 579137:METVU_RS07915
uniprot id: C9RDS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS05330
gene id: 579137:METVU_RS05330
uniprot id: C9RH97
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

579137:METVU RS08570
gene id: 579137:METVU_RS08570
uniprot id: C9RE48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

579137:METVU RS08230
gene id: 579137:METVU_RS08230
uniprot id: C9RDY3
names: Similarity
messages: Belongs to the MoaB/Mog family.

579137:METVU RS08385
gene id: 579137:METVU_RS08385
uniprot id: C9RE13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

579137:METVU RS03580
gene id: 579137:METVU_RS03580
uniprot id: C9RG85
names: Similarity
messages: Belongs to the MtxX family.

579137:METVU RS06205
gene id: 579137:METVU_RS06205
uniprot id: C9RHR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS08400
gene id: 579137:METVU_RS08400
uniprot id: C9RE15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

579137:METVU RS02740
gene id: 579137:METVU_RS02740
uniprot id: C9RFR5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

579137:METVU RS08050
gene id: 579137:METVU_RS08050
uniprot id: C9RDU9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

579137:METVU RS03860
gene id: 579137:METVU_RS03860
uniprot id: C9RGE5
names: Similarity
messages: Belongs to the UPF0235 family.

579137:METVU RS05970
gene id: 579137:METVU_RS05970
uniprot id: C9RHM2
names: Similarity
messages: Belongs to the glutaredoxin family.

579137:METVU RS07615
gene id: 579137:METVU_RS07615
uniprot id: C9RDM2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS04360
gene id: 579137:METVU_RS04360
uniprot id: C9RGP9
names: Similarity
messages: Belongs to the glutamate synthase family.

579137:METVU RS00295
gene id: 579137:METVU_RS00295
uniprot id: C9REC9
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

579137:METVU RS02430
gene id: 579137:METVU_RS02430
uniprot id: C9RFK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

579137:METVU RS02580
gene id: 579137:METVU_RS02580
uniprot id: C9RFN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

579137:METVU RS07515
gene id: 579137:METVU_RS07515
uniprot id: C9RDK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

579137:METVU RS03970
gene id: 579137:METVU_RS03970
uniprot id: C9RGG8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS08710
gene id: 579137:METVU_RS08710
uniprot id: C9RE68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

579137:METVU RS04280
gene id: 579137:METVU_RS04280
uniprot id: C9RGN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

579137:METVU RS06230
gene id: 579137:METVU_RS06230
uniprot id: C9RHS3
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

579137:METVU RS06410
gene id: 579137:METVU_RS06410
uniprot id: C9RHV9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

579137:METVU RS07015
gene id: 579137:METVU_RS07015
uniprot id: C9RI82
names: Similarity
messages: Belongs to the UPF0273 family.

579137:METVU RS06310
gene id: 579137:METVU_RS06310
uniprot id: C9RHT9
names: Similarity
messages: Belongs to the archaeal ATPase family.

579137:METVU RS05415
gene id: 579137:METVU_RS05415
uniprot id: C9RHB4
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS01130
gene id: 579137:METVU_RS01130
uniprot id: C9REU3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

579137:METVU RS01845
gene id: 579137:METVU_RS01845
uniprot id: C9RF86
names: Similarity
messages: Belongs to the ComB family.

579137:METVU RS02035
gene id: 579137:METVU_RS02035
uniprot id: C9RFC0
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS08380
gene id: 579137:METVU_RS08380
uniprot id: C9RE12
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

579137:METVU RS07230
gene id: 579137:METVU_RS07230
uniprot id: C9RIC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

579137:METVU RS06690
gene id: 579137:METVU_RS06690
uniprot id: C9RI12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

579137:METVU RS08280
gene id: 579137:METVU_RS08280
uniprot id: C9RDZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS07460
gene id: 579137:METVU_RS07460
uniprot id: C9RDJ1
names: Similarity
messages: Belongs to the AOR/FOR family.

579137:METVU RS03570
gene id: 579137:METVU_RS03570
uniprot id: C9RG83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

579137:METVU RS02145
gene id: 579137:METVU_RS02145
uniprot id: C9RFE2
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

579137:METVU RS03875
gene id: 579137:METVU_RS03875
uniprot id: C9RGE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

579137:METVU RS06400
gene id: 579137:METVU_RS06400
uniprot id: C9RHV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

579137:METVU RS03740
gene id: 579137:METVU_RS03740
uniprot id: C9RGB7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

579137:METVU RS03025
gene id: 579137:METVU_RS03025
uniprot id: C9RFX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

579137:METVU RS01265
gene id: 579137:METVU_RS01265
uniprot id: C9REX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

579137:METVU RS03640
gene id: 579137:METVU_RS03640
uniprot id: C9RG97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

579137:METVU RS04790
gene id: 579137:METVU_RS04790
uniprot id: C9RGY7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

579137:METVU RS08005
gene id: 579137:METVU_RS08005
uniprot id: C9RDU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

579137:METVU RS06290
gene id: 579137:METVU_RS06290
uniprot id: C9RHT5
names: Similarity
messages: Belongs to the FrhG family.

579137:METVU RS01030
gene id: 579137:METVU_RS01030
uniprot id: C9RES3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

579137:METVU RS07115
gene id: 579137:METVU_RS07115
uniprot id: C9RIA1
names: Similarity
messages: Belongs to the MCM family.

579137:METVU RS07595
gene id: 579137:METVU_RS07595
uniprot id: C9RDL8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

579137:METVU RS03850
gene id: 579137:METVU_RS03850
uniprot id: C9RGE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

579137:METVU RS01260
gene id: 579137:METVU_RS01260
uniprot id: C9REW9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

579137:METVU RS04990
gene id: 579137:METVU_RS04990
uniprot id: C9RH27
names: Similarity
messages: Belongs to the UPF0282 family.

579137:METVU RS02175
gene id: 579137:METVU_RS02175
uniprot id: C9RFE7
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

579137:METVU RS00525
gene id: 579137:METVU_RS00525
uniprot id: C9REH5
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

579137:METVU RS05720
gene id: 579137:METVU_RS05720
uniprot id: C9RHH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

579137:METVU RS06990
gene id: 579137:METVU_RS06990
uniprot id: C9RI77
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

579137:METVU RS03545
gene id: 579137:METVU_RS03545
uniprot id: C9RG78
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

579137:METVU RS07935
gene id: 579137:METVU_RS07935
uniprot id: C9RDS7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

579137:METVU RS01560
gene id: 579137:METVU_RS01560
uniprot id: C9RF33
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS00050
gene id: 579137:METVU_RS00050
uniprot id: C9RE81
names: Similarity
messages: Belongs to the aspartokinase family.

579137:METVU RS08310
gene id: 579137:METVU_RS08310
uniprot id: C9RDZ9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

579137:METVU RS08390
gene id: 579137:METVU_RS08390
uniprot id: C9RE14
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

579137:METVU RS01915
gene id: 579137:METVU_RS01915
uniprot id: C9RF99
names: Similarity
messages: Belongs to the UPF0215 family.

579137:METVU RS07175
gene id: 579137:METVU_RS07175
uniprot id: C9RIB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

579137:METVU RS01715
gene id: 579137:METVU_RS01715
uniprot id: C9RF60
names: Similarity
messages: Belongs to the UPF0146 family.

579137:METVU RS08260
gene id: 579137:METVU_RS08260
uniprot id: C9RDY9
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

579137:METVU RS06870
gene id: 579137:METVU_RS06870
uniprot id: C9RI53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

579137:METVU RS05360
gene id: 579137:METVU_RS05360
uniprot id: C9RHA3
names: Similarity
messages: Belongs to the P(II) protein family.

579137:METVU RS08350
gene id: 579137:METVU_RS08350
uniprot id: C9RE06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

579137:METVU RS06670
gene id: 579137:METVU_RS06670
uniprot id: C9RI08
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS07650
gene id: 579137:METVU_RS07650
uniprot id: C9RDM9
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

579137:METVU RS01120
gene id: 579137:METVU_RS01120
uniprot id: C9REU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS04375
gene id: 579137:METVU_RS04375
uniprot id: C9RGQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

579137:METVU RS07110
gene id: 579137:METVU_RS07110
uniprot id: C9RIA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

579137:METVU RS06110
gene id: 579137:METVU_RS06110
uniprot id: C9RHP9
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS08255
gene id: 579137:METVU_RS08255
uniprot id: C9RDY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

579137:METVU RS03600
gene id: 579137:METVU_RS03600
uniprot id: C9RG89
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS07165
gene id: 579137:METVU_RS07165
uniprot id: C9RIB1
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

579137:METVU RS04330
gene id: 579137:METVU_RS04330
uniprot id: C9RGP2
names: Similarity
messages: Belongs to the UPF0201 family.

579137:METVU RS00760
gene id: 579137:METVU_RS00760
uniprot id: C9REM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS06885
gene id: 579137:METVU_RS06885
uniprot id: C9RI56
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

579137:METVU RS05820
gene id: 579137:METVU_RS05820
uniprot id: C9RHJ3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

579137:METVU RS06695
gene id: 579137:METVU_RS06695
uniprot id: C9RI13
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

579137:METVU RS00930
gene id: 579137:METVU_RS00930
uniprot id: C9REQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

579137:METVU RS00305
gene id: 579137:METVU_RS00305
uniprot id: C9RED1
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

579137:METVU RS01770
gene id: 579137:METVU_RS01770
uniprot id: C9RF70
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

579137:METVU RS04685
gene id: 579137:METVU_RS04685
uniprot id: C9RGW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS02650
gene id: 579137:METVU_RS02650
uniprot id: C9RFP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

579137:METVU RS02435
gene id: 579137:METVU_RS02435
uniprot id: C9RFK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

579137:METVU RS04710
gene id: 579137:METVU_RS04710
uniprot id: C9RGX1
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

579137:METVU RS04940
gene id: 579137:METVU_RS04940
uniprot id: C9RH17
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS02625
gene id: 579137:METVU_RS02625
uniprot id: C9RFN9
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

579137:METVU RS07570
gene id: 579137:METVU_RS07570
uniprot id: C9RDL3
names: Similarity
messages: Belongs to the HisA/HisF family.

579137:METVU RS02555
gene id: 579137:METVU_RS02555
uniprot id: C9RFM5
names: Similarity
messages: Belongs to the class-I fumarase family.

579137:METVU RS01020
gene id: 579137:METVU_RS01020
uniprot id: C9RES1
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS07105
gene id: 579137:METVU_RS07105
uniprot id: C9RI99
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

579137:METVU RS07825
gene id: 579137:METVU_RS07825
uniprot id: C9RDQ4
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

579137:METVU RS07945
gene id: 579137:METVU_RS07945
uniprot id: C9RDS9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

579137:METVU RS03695
gene id: 579137:METVU_RS03695
uniprot id: C9RGA8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

579137:METVU RS00925
gene id: 579137:METVU_RS00925
uniprot id: C9REQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

579137:METVU RS05530
gene id: 579137:METVU_RS05530
uniprot id: C9RHD7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

579137:METVU RS01065
gene id: 579137:METVU_RS01065
uniprot id: C9RET0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

579137:METVU RS05435
gene id: 579137:METVU_RS05435
uniprot id: C9RHB8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS06475
gene id: 579137:METVU_RS06475
uniprot id: C9RHX2
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04080
gene id: 579137:METVU_RS04080
uniprot id: C9RGJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

579137:METVU RS01050
gene id: 579137:METVU_RS01050
uniprot id: C9RES7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

579137:METVU RS00285
gene id: 579137:METVU_RS00285
uniprot id: C9REC7
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS00255
gene id: 579137:METVU_RS00255
uniprot id: C9REC0
names: Similarity
messages: Belongs to the UPF0212 family.

579137:METVU RS03170
gene id: 579137:METVU_RS03170
uniprot id: C9RG06
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS01985
gene id: 579137:METVU_RS01985
uniprot id: C9RFB1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

579137:METVU RS05165
gene id: 579137:METVU_RS05165
uniprot id: C9RH63
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS05405
gene id: 579137:METVU_RS05405
uniprot id: C9RHB2
names: Similarity
messages: Belongs to the pyruvate kinase family.

579137:METVU RS00135
gene id: 579137:METVU_RS00135
uniprot id: C9RE97
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

579137:METVU RS05430
gene id: 579137:METVU_RS05430
uniprot id: C9RHB7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS00520
gene id: 579137:METVU_RS00520
uniprot id: C9REH4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

579137:METVU RS02590
gene id: 579137:METVU_RS02590
uniprot id: C9RFN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

579137:METVU RS06835
gene id: 579137:METVU_RS06835
uniprot id: C9RI46
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

579137:METVU RS02260
gene id: 579137:METVU_RS02260
uniprot id: C9RFG4
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS06155
gene id: 579137:METVU_RS06155
uniprot id: C9RHQ8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

579137:METVU RS01095
gene id: 579137:METVU_RS01095
uniprot id: C9RET6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

579137:METVU RS07045
gene id: 579137:METVU_RS07045
uniprot id: C9RI88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

579137:METVU RS01315
gene id: 579137:METVU_RS01315
uniprot id: C9REY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

579137:METVU RS02655
gene id: 579137:METVU_RS02655
uniprot id: C9RFP6
names: Similarity
messages: Belongs to the UPF0305 family.

579137:METVU RS01055
gene id: 579137:METVU_RS01055
uniprot id: C9RES8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS07885
gene id: 579137:METVU_RS07885
uniprot id: C9RDR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

579137:METVU RS06450
gene id: 579137:METVU_RS06450
uniprot id: C9RHW7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

579137:METVU RS07775
gene id: 579137:METVU_RS07775
uniprot id: C9RDP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

579137:METVU RS04120
gene id: 579137:METVU_RS04120
uniprot id: C9RGJ8
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

579137:METVU RS06710
gene id: 579137:METVU_RS06710
uniprot id: C9RI17
names: Similarity
messages: Belongs to the UPF0292 family.

579137:METVU RS07750
gene id: 579137:METVU_RS07750
uniprot id: C9RDN8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

579137:METVU RS03205
gene id: 579137:METVU_RS03205
uniprot id: C9RG14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

579137:METVU RS07820
gene id: 579137:METVU_RS07820
uniprot id: C9RDQ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

579137:METVU RS05495
gene id: 579137:METVU_RS05495
uniprot id: C9RHD0
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

579137:METVU RS08315
gene id: 579137:METVU_RS08315
uniprot id: C9RE00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

579137:METVU RS02950
gene id: 579137:METVU_RS02950
uniprot id: C9RFW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

579137:METVU RS00415
gene id: 579137:METVU_RS00415
uniprot id: C9REF3
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

579137:METVU RS01890
gene id: 579137:METVU_RS01890
uniprot id: C9RF94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

579137:METVU RS05630
gene id: 579137:METVU_RS05630
uniprot id: C9RHF7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

579137:METVU RS07525
gene id: 579137:METVU_RS07525
uniprot id: C9RDK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

579137:METVU RS08275
gene id: 579137:METVU_RS08275
uniprot id: C9RDZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

579137:METVU RS07850
gene id: 579137:METVU_RS07850
uniprot id: C9RDQ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS01895
gene id: 579137:METVU_RS01895
uniprot id: C9RF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

579137:METVU RS07590
gene id: 579137:METVU_RS07590
uniprot id: C9RDL7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

579137:METVU RS06850
gene id: 579137:METVU_RS06850
uniprot id: C9RI49
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

579137:METVU RS04635
gene id: 579137:METVU_RS04635
uniprot id: C9RGV6
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

579137:METVU RS08560
gene id: 579137:METVU_RS08560
uniprot id: C9RE46
names: Similarity
messages: Belongs to the P(II) protein family.

579137:METVU RS07065
gene id: 579137:METVU_RS07065
uniprot id: C9RI91
names: Similarity
messages: Belongs to the radical SAM superfamily. NifB family.

579137:METVU RS02735
gene id: 579137:METVU_RS02735
uniprot id: C9RFR4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

579137:METVU RS00605
gene id: 579137:METVU_RS00605
uniprot id: C9REJ0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

579137:METVU RS00450
gene id: 579137:METVU_RS00450
uniprot id: C9REG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

579137:METVU RS08715
gene id: 579137:METVU_RS08715
uniprot id: C9RE69
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS03845
gene id: 579137:METVU_RS03845
uniprot id: C9RGE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

579137:METVU RS04815
gene id: 579137:METVU_RS04815
uniprot id: C9RGZ2
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS06235
gene id: 579137:METVU_RS06235
uniprot id: C9RHS4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

579137:METVU RS08025
gene id: 579137:METVU_RS08025
uniprot id: C9RDU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

579137:METVU RS06875
gene id: 579137:METVU_RS06875
uniprot id: C9RI54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

579137:METVU RS03635
gene id: 579137:METVU_RS03635
uniprot id: C9RG96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

579137:METVU RS00015
gene id: 579137:METVU_RS00015
uniprot id: C9RE74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

579137:METVU RS06380
gene id: 579137:METVU_RS06380
uniprot id: C9RHV3
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

579137:METVU RS08225
gene id: 579137:METVU_RS08225
uniprot id: C9RDY2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

579137:METVU RS06890
gene id: 579137:METVU_RS06890
uniprot id: C9RI57
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

579137:METVU RS04970
gene id: 579137:METVU_RS04970
uniprot id: C9RH23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

579137:METVU RS06860
gene id: 579137:METVU_RS06860
uniprot id: C9RI51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

579137:METVU RS02680
gene id: 579137:METVU_RS02680
uniprot id: C9RFQ1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

579137:METVU RS04890
gene id: 579137:METVU_RS04890
uniprot id: C9RH07
names: Similarity
messages: Belongs to the AAA ATPase family.

579137:METVU RS06265
gene id: 579137:METVU_RS06265
uniprot id: C9RHT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

579137:METVU RS07485
gene id: 579137:METVU_RS07485
uniprot id: C9RDJ6
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

579137:METVU RS04225
gene id: 579137:METVU_RS04225
uniprot id: C9RGL9
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04455
gene id: 579137:METVU_RS04455
uniprot id: C9RGR8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

579137:METVU RS04755
gene id: 579137:METVU_RS04755
uniprot id: C9RGY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

579137:METVU RS05780
gene id: 579137:METVU_RS05780
uniprot id: C9RHI5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

579137:METVU RS06570
gene id: 579137:METVU_RS06570
uniprot id: C9RHZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

579137:METVU RS05625
gene id: 579137:METVU_RS05625
uniprot id: C9RHF6
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

579137:METVU RS00740
gene id: 579137:METVU_RS00740
uniprot id: C9REL6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS04675
gene id: 579137:METVU_RS04675
uniprot id: C9RGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

579137:METVU RS04605
gene id: 579137:METVU_RS04605
uniprot id: C9RGU9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

579137:METVU RS07960
gene id: 579137:METVU_RS07960
uniprot id: C9RDT2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

579137:METVU RS01090
gene id: 579137:METVU_RS01090
uniprot id: C9RET5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS04715
gene id: 579137:METVU_RS04715
uniprot id: C9RGX2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

579137:METVU RS04275
gene id: 579137:METVU_RS04275
uniprot id: C9RGN0
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

579137:METVU RS03045
gene id: 579137:METVU_RS03045
uniprot id: C9RFY1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

579137:METVU RS06435
gene id: 579137:METVU_RS06435
uniprot id: C9RHW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

579137:METVU RS00065
gene id: 579137:METVU_RS00065
uniprot id: C9RE84
names: Similarity
messages: Belongs to the TrpC family.

579137:METVU RS06760
gene id: 579137:METVU_RS06760
uniprot id: C9RI27
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

579137:METVU RS04020
gene id: 579137:METVU_RS04020
uniprot id: C9RGH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

579137:METVU RS03730
gene id: 579137:METVU_RS03730
uniprot id: C9RGB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

579137:METVU RS03145
gene id: 579137:METVU_RS03145
uniprot id: C9RG01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

579137:METVU RS07490
gene id: 579137:METVU_RS07490
uniprot id: C9RDJ7
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

579137:METVU RS03285
gene id: 579137:METVU_RS03285
uniprot id: C9RG27
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

579137:METVU RS00380
gene id: 579137:METVU_RS00380
uniprot id: C9REE6
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

579137:METVU RS01495
gene id: 579137:METVU_RS01495
uniprot id: C9RF18
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS08090
gene id: 579137:METVU_RS08090
uniprot id: C9RDV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

579137:METVU RS05740
gene id: 579137:METVU_RS05740
uniprot id: C9RHH8
names: Similarity
messages: Belongs to the peptidase U62 family.

579137:METVU RS05440
gene id: 579137:METVU_RS05440
uniprot id: C9RHB9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

579137:METVU RS00640
gene id: 579137:METVU_RS00640
uniprot id: C9REJ8
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS03105
gene id: 579137:METVU_RS03105
uniprot id: C9RFZ3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

579137:METVU RS07880
gene id: 579137:METVU_RS07880
uniprot id: C9RDR5
names: Function
messages: Probably involved in the biogenesis of the ribosome.

579137:METVU RS08110
gene id: 579137:METVU_RS08110
uniprot id: C9RDW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

579137:METVU RS05770
gene id: 579137:METVU_RS05770
uniprot id: C9RHI3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

579137:METVU RS04830
gene id: 579137:METVU_RS04830
uniprot id: C9RGZ5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

579137:METVU RS07520
gene id: 579137:METVU_RS07520
uniprot id: C9RDK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS04190
gene id: 579137:METVU_RS04190
uniprot id: C9RGL2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

579137:METVU RS05885
gene id: 579137:METVU_RS05885
uniprot id: C9RHK6
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

579137:METVU RS05665
gene id: 579137:METVU_RS05665
uniprot id: C9RHG4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

579137:METVU RS00790
gene id: 579137:METVU_RS00790
uniprot id: C9REM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

579137:METVU RS08085
gene id: 579137:METVU_RS08085
uniprot id: C9RDV5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

579137:METVU RS04090
gene id: 579137:METVU_RS04090
uniprot id: C9RGJ2
names: Similarity
messages: Belongs to the PstS family.

579137:METVU RS06160
gene id: 579137:METVU_RS06160
uniprot id: C9RHQ9
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

579137:METVU RS04530
gene id: 579137:METVU_RS04530
uniprot id: C9RGT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

579137:METVU RS08530
gene id: 579137:METVU_RS08530
uniprot id: C9RE40
names: Similarity
messages: Belongs to the HMD family.

579137:METVU RS05760
gene id: 579137:METVU_RS05760
uniprot id: C9RHI1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

579137:METVU RS01950
gene id: 579137:METVU_RS01950
uniprot id: C9RFA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

579137:METVU RS02450
gene id: 579137:METVU_RS02450
uniprot id: C9RFK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

579137:METVU RS07380
gene id: 579137:METVU_RS07380
uniprot id: C9RIF2
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

579137:METVU RS05290
gene id: 579137:METVU_RS05290
uniprot id: C9RH89
names: Similarity
messages: Belongs to the P(II) protein family.

579137:METVU RS01035
gene id: 579137:METVU_RS01035
uniprot id: C9RES4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

579137:METVU RS07830
gene id: 579137:METVU_RS07830
uniprot id: C9RDQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

579137:METVU RS04930
gene id: 579137:METVU_RS04930
uniprot id: C9RH15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

579137:METVU RS06575
gene id: 579137:METVU_RS06575
uniprot id: C9RHZ1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

579137:METVU RS05500
gene id: 579137:METVU_RS05500
uniprot id: C9RHD1
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

579137:METVU RS08455
gene id: 579137:METVU_RS08455
uniprot id: C9RE26
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS04055
gene id: 579137:METVU_RS04055
uniprot id: C9RGI5
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

579137:METVU RS05570
gene id: 579137:METVU_RS05570
uniprot id: C9RHE5
names: Similarity
messages: Belongs to the AAA ATPase family.

579137:METVU RS00620
gene id: 579137:METVU_RS00620
uniprot id: C9REJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

579137:METVU RS01075
gene id: 579137:METVU_RS01075
uniprot id: C9RET2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS03810
gene id: 579137:METVU_RS03810
uniprot id: C9RGD5
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

579137:METVU RS03940
gene id: 579137:METVU_RS03940
uniprot id: C9RGG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

579137:METVU RS08095
gene id: 579137:METVU_RS08095
uniprot id: C9RDV7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

579137:METVU RS07855
gene id: 579137:METVU_RS07855
uniprot id: C9RDR0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

579137:METVU RS05200
gene id: 579137:METVU_RS05200
uniprot id: C9RH71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

579137:METVU RS07195
gene id: 579137:METVU_RS07195
uniprot id: C9RIB7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

579137:METVU RS05650
gene id: 579137:METVU_RS05650
uniprot id: C9RHG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

579137:METVU RS00045
gene id: 579137:METVU_RS00045
uniprot id: C9RE80
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

579137:METVU RS02465
gene id: 579137:METVU_RS02465
uniprot id: C9RFK7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

579137:METVU RS05145
gene id: 579137:METVU_RS05145
uniprot id: C9RH59
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

579137:METVU RS03015
gene id: 579137:METVU_RS03015
uniprot id: C9RFX5
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

579137:METVU RS00495
gene id: 579137:METVU_RS00495
uniprot id: C9REG9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS00770
gene id: 579137:METVU_RS00770
uniprot id: C9REM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS05250
gene id: 579137:METVU_RS05250
uniprot id: C9RH81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

579137:METVU RS08300
gene id: 579137:METVU_RS08300
uniprot id: C9RDZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

579137:METVU RS06140
gene id: 579137:METVU_RS06140
uniprot id: C9RHQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

579137:METVU RS04785
gene id: 579137:METVU_RS04785
uniprot id: C9RGY6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

579137:METVU RS01305
gene id: 579137:METVU_RS01305
uniprot id: C9REX8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

579137:METVU RS05195
gene id: 579137:METVU_RS05195
uniprot id: C9RH69
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

579137:METVU RS01795
gene id: 579137:METVU_RS01795
uniprot id: C9RF76
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

579137:METVU RS07735
gene id: 579137:METVU_RS07735
uniprot id: C9RDN5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

579137:METVU RS07150
gene id: 579137:METVU_RS07150
uniprot id: C9RIA8
names: Similarity
messages: Belongs to the NodU/CmcH family.

579137:METVU RS04955
gene id: 579137:METVU_RS04955
uniprot id: C9RH20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

579137:METVU RS07255
gene id: 579137:METVU_RS07255
uniprot id: C9RIC7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

579137:METVU RS03995
gene id: 579137:METVU_RS03995
uniprot id: C9RGH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

579137:METVU RS07765
gene id: 579137:METVU_RS07765
uniprot id: C9RDP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

579137:METVU RS07780
gene id: 579137:METVU_RS07780
uniprot id: C9RDP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

579137:METVU RS01070
gene id: 579137:METVU_RS01070
uniprot id: C9RET1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS08080
gene id: 579137:METVU_RS08080
uniprot id: C9RDV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

579137:METVU RS01210
gene id: 579137:METVU_RS01210
uniprot id: C9REV9
names: Similarity
messages: Belongs to the UPF0166 family.

579137:METVU RS07495
gene id: 579137:METVU_RS07495
uniprot id: C9RDJ8
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

579137:METVU RS01320
gene id: 579137:METVU_RS01320
uniprot id: C9REY2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

579137:METVU RS00600
gene id: 579137:METVU_RS00600
uniprot id: C9REI9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS08725
gene id: 579137:METVU_RS08725
uniprot id: C9RE71
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

579137:METVU RS07600
gene id: 579137:METVU_RS07600
uniprot id: C9RDL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

579137:METVU RS07435
gene id: 579137:METVU_RS07435
uniprot id: C9RIG3
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS07145
gene id: 579137:METVU_RS07145
uniprot id: C9RIA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

579137:METVU RS05280
gene id: 579137:METVU_RS05280
uniprot id: C9RH87
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-109 inactivates the nitrogenase reductase and regulates nitrogenase activity.

579137:METVU RS05610
gene id: 579137:METVU_RS05610
uniprot id: C9RHF3
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

579137:METVU RS01675
gene id: 579137:METVU_RS01675
uniprot id: C9RF53
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

579137:METVU RS01455
gene id: 579137:METVU_RS01455
uniprot id: C9RF10
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS03900
gene id: 579137:METVU_RS03900
uniprot id: C9RGF3
names: Similarity
messages: Belongs to the FwdC/FmdC family.

579137:METVU RS03890
gene id: 579137:METVU_RS03890
uniprot id: C9RGF1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

579137:METVU RS07655
gene id: 579137:METVU_RS07655
uniprot id: C9RDN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

579137:METVU RS07440
gene id: 579137:METVU_RS07440
uniprot id: C9RDI7
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS06865
gene id: 579137:METVU_RS06865
uniprot id: C9RI52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS02315
gene id: 579137:METVU_RS02315
uniprot id: C9RFH7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

579137:METVU RS02570
gene id: 579137:METVU_RS02570
uniprot id: C9RFM8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS08010
gene id: 579137:METVU_RS08010
uniprot id: C9RDU1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

579137:METVU RS05840
gene id: 579137:METVU_RS05840
uniprot id: C9RHJ7
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

579137:METVU RS00945
gene id: 579137:METVU_RS00945
uniprot id: C9REQ6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS06975
gene id: 579137:METVU_RS06975
uniprot id: C9RI74
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS05620
gene id: 579137:METVU_RS05620
uniprot id: C9RHF5
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

579137:METVU RS06980
gene id: 579137:METVU_RS06980
uniprot id: C9RI75
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

579137:METVU RS04645
gene id: 579137:METVU_RS04645
uniprot id: C9RGV8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

579137:METVU RS00690
gene id: 579137:METVU_RS00690
uniprot id: C9REK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

579137:METVU RS00940
gene id: 579137:METVU_RS00940
uniprot id: C9REQ5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

579137:METVU RS02470
gene id: 579137:METVU_RS02470
uniprot id: C9RFK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

579137:METVU RS08595
gene id: 579137:METVU_RS08595
uniprot id: C9RE53
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

579137:METVU RS07920
gene id: 579137:METVU_RS07920
uniprot id: C9RDS3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

579137:METVU RS08485
gene id: 579137:METVU_RS08485
uniprot id: C9RE32
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

579137:METVU RS06485
gene id: 579137:METVU_RS06485
uniprot id: C9RHX4
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04050
gene id: 579137:METVU_RS04050
uniprot id: C9RGI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

579137:METVU RS05705
gene id: 579137:METVU_RS05705
uniprot id: C9RHH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

579137:METVU RS03430
gene id: 579137:METVU_RS03430
uniprot id: C9RG55
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

579137:METVU RS01515
gene id: 579137:METVU_RS01515
uniprot id: C9RF22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

579137:METVU RS08775
gene id: 579137:METVU_RS08775
uniprot id: C9RIH4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

579137:METVU RS04445
gene id: 579137:METVU_RS04445
uniprot id: C9RGR6
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

579137:METVU RS00185
gene id: 579137:METVU_RS00185
uniprot id: C9REA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

579137:METVU RS01735
gene id: 579137:METVU_RS01735
uniprot id: C9RF64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS03530
gene id: 579137:METVU_RS03530
uniprot id: C9RG75
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

579137:METVU RS03585
gene id: 579137:METVU_RS03585
uniprot id: C9RG86
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS00805
gene id: 579137:METVU_RS00805
uniprot id: C9REM8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS02190
gene id: 579137:METVU_RS02190
uniprot id: C9RFF0
names: Similarity
messages: Belongs to the HdrC family.

579137:METVU RS05930
gene id: 579137:METVU_RS05930
uniprot id: C9RHL5
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

579137:METVU RS00825
gene id: 579137:METVU_RS00825
uniprot id: C9REN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

579137:METVU RS06960
gene id: 579137:METVU_RS06960
uniprot id: C9RI71
names: Similarity
messages: Belongs to the HMD family.

579137:METVU RS04075
gene id: 579137:METVU_RS04075
uniprot id: C9RGI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

579137:METVU RS01545
gene id: 579137:METVU_RS01545
uniprot id: C9RF30
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS03505
gene id: 579137:METVU_RS03505
uniprot id: C9RG70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

579137:METVU RS05870
gene id: 579137:METVU_RS05870
uniprot id: C9RHK3
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

579137:METVU RS01285
gene id: 579137:METVU_RS01285
uniprot id: C9REX4
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

579137:METVU RS01370
gene id: 579137:METVU_RS01370
uniprot id: C9REZ2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

579137:METVU RS04380
gene id: 579137:METVU_RS04380
uniprot id: C9RGQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

579137:METVU RS03690
gene id: 579137:METVU_RS03690
uniprot id: C9RGA7
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

579137:METVU RS00745
gene id: 579137:METVU_RS00745
uniprot id: C9REL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS02690
gene id: 579137:METVU_RS02690
uniprot id: C9RFQ3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

579137:METVU RS02070
gene id: 579137:METVU_RS02070
uniprot id: C9RFC7
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04585
gene id: 579137:METVU_RS04585
uniprot id: C9RGU5
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

579137:METVU RS04680
gene id: 579137:METVU_RS04680
uniprot id: C9RGW5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

579137:METVU RS08055
gene id: 579137:METVU_RS08055
uniprot id: C9RDV0
names: Similarity
messages: Belongs to the HupF/HypC family.

579137:METVU RS06515
gene id: 579137:METVU_RS06515
uniprot id: C9RHY0
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

579137:METVU RS04505
gene id: 579137:METVU_RS04505
uniprot id: C9RGS8
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS01105
gene id: 579137:METVU_RS01105
uniprot id: C9RET8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

579137:METVU RS00390
gene id: 579137:METVU_RS00390
uniprot id: C9REE8
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

579137:METVU RS07980
gene id: 579137:METVU_RS07980
uniprot id: C9RDT6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

579137:METVU RS05340
gene id: 579137:METVU_RS05340
uniprot id: C9RH99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

579137:METVU RS05845
gene id: 579137:METVU_RS05845
uniprot id: C9RHJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

579137:METVU RS00735
gene id: 579137:METVU_RS00735
uniprot id: C9REL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

579137:METVU RS06585
gene id: 579137:METVU_RS06585
uniprot id: C9RHZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

579137:METVU RS05800
gene id: 579137:METVU_RS05800
uniprot id: C9RHI9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS05485
gene id: 579137:METVU_RS05485
uniprot id: C9RHC8
names: Similarity
messages: Belongs to the UPF0251 family.

579137:METVU RS05285
gene id: 579137:METVU_RS05285
uniprot id: C9RH88
names: Similarity
messages: Belongs to the P(II) protein family.

579137:METVU RS03355
gene id: 579137:METVU_RS03355
uniprot id: C9RG40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

579137:METVU RS06370
gene id: 579137:METVU_RS06370
uniprot id: C9RHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

579137:METVU RS08655
gene id: 579137:METVU_RS08655
uniprot id: C9RE64
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

579137:METVU RS00370
gene id: 579137:METVU_RS00370
uniprot id: C9REE4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04170
gene id: 579137:METVU_RS04170
uniprot id: C9RGK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

579137:METVU RS02185
gene id: 579137:METVU_RS02185
uniprot id: C9RFE9
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

579137:METVU RS02265
gene id: 579137:METVU_RS02265
uniprot id: C9RFG5
names: Function
names: Similarity
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

579137:METVU RS03140
gene id: 579137:METVU_RS03140
uniprot id: C9RG00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

579137:METVU RS05345
gene id: 579137:METVU_RS05345
uniprot id: C9RHA0
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

579137:METVU RS06055
gene id: 579137:METVU_RS06055
uniprot id: C9RHN9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04070
gene id: 579137:METVU_RS04070
uniprot id: C9RGI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

579137:METVU RS07120
gene id: 579137:METVU_RS07120
uniprot id: C9RIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

579137:METVU RS03645
gene id: 579137:METVU_RS03645
uniprot id: C9RG98
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

579137:METVU RS02335
gene id: 579137:METVU_RS02335
uniprot id: C9RFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EhaA family.
messages: Cell membrane
messages: Membrane
messages: One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.
messages: Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits.

579137:METVU RS05960
gene id: 579137:METVU_RS05960
uniprot id: C9RHM0
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

579137:METVU RS06565
gene id: 579137:METVU_RS06565
uniprot id: C9RHY9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

579137:METVU RS04270
gene id: 579137:METVU_RS04270
uniprot id: C9RGM9
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

579137:METVU RS03610
gene id: 579137:METVU_RS03610
uniprot id: C9RG91
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

579137:METVU RS04540
gene id: 579137:METVU_RS04540
uniprot id: C9RGT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS08295
gene id: 579137:METVU_RS08295
uniprot id: C9RDZ6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

579137:METVU RS03755
gene id: 579137:METVU_RS03755
uniprot id: C9RGC0
names: Subunit
messages: Homotetramer.

579137:METVU RS06855
gene id: 579137:METVU_RS06855
uniprot id: C9RI50
names: Similarity
messages: Belongs to the UPF0210 family.

579137:METVU RS07835
gene id: 579137:METVU_RS07835
uniprot id: C9RDQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

579137:METVU RS04440
gene id: 579137:METVU_RS04440
uniprot id: C9RGR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

579137:METVU RS06030
gene id: 579137:METVU_RS06030
uniprot id: C9RHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

579137:METVU RS08245
gene id: 579137:METVU_RS08245
uniprot id: C9RDY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

579137:METVU RS04950
gene id: 579137:METVU_RS04950
uniprot id: C9RH19
names: Similarity
messages: Belongs to the thymidylate kinase family.

579137:METVU RS04045
gene id: 579137:METVU_RS04045
uniprot id: C9RGI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

579137:METVU RS06830
gene id: 579137:METVU_RS06830
uniprot id: C9RI45
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

579137:METVU RS02660
gene id: 579137:METVU_RS02660
uniprot id: C9RFP7
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS02275
gene id: 579137:METVU_RS02275
uniprot id: C9RFG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

579137:METVU RS00655
gene id: 579137:METVU_RS00655
uniprot id: C9REK1
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS08700
gene id: 579137:METVU_RS08700
uniprot id: C9RE67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

579137:METVU RS07900
gene id: 579137:METVU_RS07900
uniprot id: C9RDR9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

579137:METVU RS05520
gene id: 579137:METVU_RS05520
uniprot id: C9RHD5
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS05915
gene id: 579137:METVU_RS05915
uniprot id: C9RHL2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

579137:METVU RS06500
gene id: 579137:METVU_RS06500
uniprot id: C9RHX7
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS06240
gene id: 579137:METVU_RS06240
uniprot id: C9RHS5
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

579137:METVU RS03100
gene id: 579137:METVU_RS03100
uniprot id: C9RFZ2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

579137:METVU RS05730
gene id: 579137:METVU_RS05730
uniprot id: C9RHH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

579137:METVU RS08130
gene id: 579137:METVU_RS08130
uniprot id: C9RDW3
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

579137:METVU RS04610
gene id: 579137:METVU_RS04610
uniprot id: C9RGV0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

579137:METVU RS05765
gene id: 579137:METVU_RS05765
uniprot id: C9RHI2
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS03575
gene id: 579137:METVU_RS03575
uniprot id: C9RG84
names: Similarity
messages: Belongs to the UPF0285 family.

579137:METVU RS01615
gene id: 579137:METVU_RS01615
uniprot id: C9RF44
names: Similarity
messages: Belongs to the archaeal ATPase family.

579137:METVU RS03120
gene id: 579137:METVU_RS03120
uniprot id: C9RFZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

579137:METVU RS03235
gene id: 579137:METVU_RS03235
uniprot id: C9RG20
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

579137:METVU RS05805
gene id: 579137:METVU_RS05805
uniprot id: C9RHJ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

579137:METVU RS00885
gene id: 579137:METVU_RS00885
uniprot id: C9REP4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS02670
gene id: 579137:METVU_RS02670
uniprot id: C9RFP9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

579137:METVU RS01485
gene id: 579137:METVU_RS01485
uniprot id: C9RF16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

579137:METVU RS03440
gene id: 579137:METVU_RS03440
uniprot id: C9RG57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

579137:METVU RS04580
gene id: 579137:METVU_RS04580
uniprot id: C9RGU4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

579137:METVU RS00900
gene id: 579137:METVU_RS00900
uniprot id: C9REP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

579137:METVU RS03655
gene id: 579137:METVU_RS03655
uniprot id: C9RGA0
names: Similarity
messages: Belongs to the LarC family.

579137:METVU RS01765
gene id: 579137:METVU_RS01765
uniprot id: C9RF69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

579137:METVU RS05020
gene id: 579137:METVU_RS05020
uniprot id: C9RH34
names: Similarity
messages: Belongs to the HerA family.

579137:METVU RS01925
gene id: 579137:METVU_RS01925
uniprot id: C9RFA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

579137:METVU RS06985
gene id: 579137:METVU_RS06985
uniprot id: C9RI76
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

579137:METVU RS01060
gene id: 579137:METVU_RS01060
uniprot id: C9RES9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

579137:METVU RS03985
gene id: 579137:METVU_RS03985
uniprot id: C9RGH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

579137:METVU RS00610
gene id: 579137:METVU_RS00610
uniprot id: C9REJ1
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS06495
gene id: 579137:METVU_RS06495
uniprot id: C9RHX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04670
gene id: 579137:METVU_RS04670
uniprot id: C9RGW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

579137:METVU RS02575
gene id: 579137:METVU_RS02575
uniprot id: C9RFM9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS03425
gene id: 579137:METVU_RS03425
uniprot id: C9RG54
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

579137:METVU RS02460
gene id: 579137:METVU_RS02460
uniprot id: C9RFK6
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

579137:METVU RS06005
gene id: 579137:METVU_RS06005
uniprot id: C9RHM9
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

579137:METVU RS08265
gene id: 579137:METVU_RS08265
uniprot id: C9RDZ0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

579137:METVU RS02605
gene id: 579137:METVU_RS02605
uniprot id: C9RFN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

579137:METVU RS00775
gene id: 579137:METVU_RS00775
uniprot id: C9REM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS00455
gene id: 579137:METVU_RS00455
uniprot id: C9REG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

579137:METVU RS01720
gene id: 579137:METVU_RS01720
uniprot id: C9RF61
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

579137:METVU RS07280
gene id: 579137:METVU_RS07280
uniprot id: C9RID3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

579137:METVU RS07585
gene id: 579137:METVU_RS07585
uniprot id: C9RDL6
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS06195
gene id: 579137:METVU_RS06195
uniprot id: C9RHR6
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

579137:METVU RS01025
gene id: 579137:METVU_RS01025
uniprot id: C9RES2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

579137:METVU RS03410
gene id: 579137:METVU_RS03410
uniprot id: C9RG51
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

579137:METVU RS07260
gene id: 579137:METVU_RS07260
uniprot id: C9RIC9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

579137:METVU RS03965
gene id: 579137:METVU_RS03965
uniprot id: C9RGG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

579137:METVU RS01310
gene id: 579137:METVU_RS01310
uniprot id: C9REY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

579137:METVU RS01840
gene id: 579137:METVU_RS01840
uniprot id: C9RF85
names: Subunit
messages: Homotetramer.

579137:METVU RS05255
gene id: 579137:METVU_RS05255
uniprot id: C9RH82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

579137:METVU RS03680
gene id: 579137:METVU_RS03680
uniprot id: C9RGA5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

579137:METVU RS05245
gene id: 579137:METVU_RS05245
uniprot id: C9RH80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

579137:METVU RS06035
gene id: 579137:METVU_RS06035
uniprot id: C9RHN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

579137:METVU RS00565
gene id: 579137:METVU_RS00565
uniprot id: C9REI2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS02120
gene id: 579137:METVU_RS02120
uniprot id: C9RFD7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

579137:METVU RS06220
gene id: 579137:METVU_RS06220
uniprot id: C9RHS2
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

579137:METVU RS08235
gene id: 579137:METVU_RS08235
uniprot id: C9RDY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

579137:METVU RS00765
gene id: 579137:METVU_RS00765
uniprot id: C9REM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS03625
gene id: 579137:METVU_RS03625
uniprot id: C9RG94
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

579137:METVU RS01175
gene id: 579137:METVU_RS01175
uniprot id: C9REV2
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

579137:METVU RS08290
gene id: 579137:METVU_RS08290
uniprot id: C9RDZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

579137:METVU RS03150
gene id: 579137:METVU_RS03150
uniprot id: C9RG02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

579137:METVU RS06785
gene id: 579137:METVU_RS06785
uniprot id: C9RI36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

579137:METVU RS01390
gene id: 579137:METVU_RS01390
uniprot id: C9REZ6
names: Similarity
messages: Belongs to the HdrC family.

579137:METVU RS05325
gene id: 579137:METVU_RS05325
uniprot id: C9RH96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

579137:METVU RS08330
gene id: 579137:METVU_RS08330
uniprot id: C9RE03
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS03360
gene id: 579137:METVU_RS03360
uniprot id: C9RG41
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

579137:METVU RS00755
gene id: 579137:METVU_RS00755
uniprot id: C9REL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

579137:METVU RS04695
gene id: 579137:METVU_RS04695
uniprot id: C9RGW8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

579137:METVU RS08285
gene id: 579137:METVU_RS08285
uniprot id: C9RDZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

579137:METVU RS07100
gene id: 579137:METVU_RS07100
uniprot id: C9RI98
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

579137:METVU RS03675
gene id: 579137:METVU_RS03675
uniprot id: C9RGA4
names: Similarity
messages: Belongs to the DtxR/MntR family.

579137:METVU RS08645
gene id: 579137:METVU_RS08645
uniprot id: C9RE62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

579137:METVU RS02150
gene id: 579137:METVU_RS02150
uniprot id: C9RFE3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

579137:METVU RS06045
gene id: 579137:METVU_RS06045
uniprot id: C9RHN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

579137:METVU RS02725
gene id: 579137:METVU_RS02725
uniprot id: C9RFR2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

579137:METVU RS04200
gene id: 579137:METVU_RS04200
uniprot id: C9RGL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS02620
gene id: 579137:METVU_RS02620
uniprot id: C9RFN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

579137:METVU RS02305
gene id: 579137:METVU_RS02305
uniprot id: C9RFH5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

579137:METVU RS07395
gene id: 579137:METVU_RS07395
uniprot id: C9RIF5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

579137:METVU RS05385
gene id: 579137:METVU_RS05385
uniprot id: C9RHA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

579137:METVU RS01180
gene id: 579137:METVU_RS01180
uniprot id: C9REV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

579137:METVU RS07420
gene id: 579137:METVU_RS07420
uniprot id: C9RIG0
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS04705
gene id: 579137:METVU_RS04705
uniprot id: C9RGX0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

579137:METVU RS00160
gene id: 579137:METVU_RS00160
uniprot id: C9REA2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

579137:METVU RS07895
gene id: 579137:METVU_RS07895
uniprot id: C9RDR8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

579137:METVU RS06810
gene id: 579137:METVU_RS06810
uniprot id: C9RI41
names: Similarity
messages: Belongs to the UPF0128 family.

579137:METVU RS01460
gene id: 579137:METVU_RS01460
uniprot id: C9RF11
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS01580
gene id: 579137:METVU_RS01580
uniprot id: C9RF37
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS08105
gene id: 579137:METVU_RS08105
uniprot id: C9RDV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

579137:METVU RS04350
gene id: 579137:METVU_RS04350
uniprot id: C9RGP6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

579137:METVU RS01170
gene id: 579137:METVU_RS01170
uniprot id: C9REV1
names: Similarity
messages: Belongs to the UPF0284 family.

579137:METVU RS01860
gene id: 579137:METVU_RS01860
uniprot id: C9RF89
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

579137:METVU RS08325
gene id: 579137:METVU_RS08325
uniprot id: C9RE02
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

579137:METVU RS06995
gene id: 579137:METVU_RS06995
uniprot id: C9RI78
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

579137:METVU RS01435
gene id: 579137:METVU_RS01435
uniprot id: C9RF06
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

579137:METVU RS04325
gene id: 579137:METVU_RS04325
uniprot id: C9RGP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

579137:METVU RS03115
gene id: 579137:METVU_RS03115
uniprot id: C9RFZ5
names: Similarity
names: Subunit
messages: Belongs to the L-cysteine desulfidase family.
messages: Homotrimer.

579137:METVU RS05795
gene id: 579137:METVU_RS05795
uniprot id: C9RHI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

579137:METVU RS04560
gene id: 579137:METVU_RS04560
uniprot id: C9RGT9
names: Similarity
messages: Belongs to the HsdR family.

579137:METVU RS05880
gene id: 579137:METVU_RS05880
uniprot id: C9RHK5
names: Similarity
messages: Belongs to the UPF0248 family.

579137:METVU RS00530
gene id: 579137:METVU_RS00530
uniprot id: C9REH6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

579137:METVU RS04965
gene id: 579137:METVU_RS04965
uniprot id: C9RH22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

579137:METVU RS00835
gene id: 579137:METVU_RS00835
uniprot id: C9REN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

579137:METVU RS05420
gene id: 579137:METVU_RS05420
uniprot id: C9RHB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

579137:METVU RS04800
gene id: 579137:METVU_RS04800
uniprot id: C9RGY9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

579137:METVU RS04205
gene id: 579137:METVU_RS04205
uniprot id: C9RGL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

579137:METVU RS02115
gene id: 579137:METVU_RS02115
uniprot id: C9RFD6
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

579137:METVU RS00860
gene id: 579137:METVU_RS00860
uniprot id: C9REN9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

579137:METVU RS05935
gene id: 579137:METVU_RS05935
uniprot id: C9RHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

579137:METVU RS07635
gene id: 579137:METVU_RS07635
uniprot id: C9RDM6
names: Similarity
messages: Belongs to the UPF0111 family.

579137:METVU RS01430
gene id: 579137:METVU_RS01430
uniprot id: C9RF05
names: Similarity
messages: Belongs to the UPF0173 family.

579137:METVU RS04935
gene id: 579137:METVU_RS04935
uniprot id: C9RH16
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

579137:METVU RS01465
gene id: 579137:METVU_RS01465
uniprot id: C9RF12
names: Subcellular Location Annotation
messages: Membrane

579137:METVU RS01800
gene id: 579137:METVU_RS01800
uniprot id: C9RF77
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

579137:METVU RS04320
gene id: 579137:METVU_RS04320
uniprot id: C9RGP0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.