575540:ISOP RS00235
gene id: 575540:ISOP_RS00235
uniprot id: E8R4Q2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

575540:ISOP RS07795
gene id: 575540:ISOP_RS07795
uniprot id: E8QY55
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

575540:ISOP RS02970
gene id: 575540:ISOP_RS02970
uniprot id: E8R030
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell inner membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

575540:ISOP RS03405
gene id: 575540:ISOP_RS03405
uniprot id: E8R0P9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

575540:ISOP RS15445
gene id: 575540:ISOP_RS15445
uniprot id: E8R1N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

575540:ISOP RS02400
gene id: 575540:ISOP_RS02400
uniprot id: E8QYS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

575540:ISOP RS14215
gene id: 575540:ISOP_RS14215
uniprot id: E8QZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

575540:ISOP RS11265
gene id: 575540:ISOP_RS11265
uniprot id: E8R3T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

575540:ISOP RS08010
gene id: 575540:ISOP_RS08010
uniprot id: E8QYV0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

575540:ISOP RS05380
gene id: 575540:ISOP_RS05380
uniprot id: E8R416
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS07370
gene id: 575540:ISOP_RS07370
uniprot id: E8QXC9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

575540:ISOP RS07430
gene id: 575540:ISOP_RS07430
uniprot id: E8QXE0
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS10630
gene id: 575540:ISOP_RS10630
uniprot id: E8R337
names: Similarity
messages: Belongs to the Fur family.

575540:ISOP RS04080
gene id: 575540:ISOP_RS04080
uniprot id: E8R1T5
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

575540:ISOP RS05715
gene id: 575540:ISOP_RS05715
uniprot id: E8R4R9
names: Function
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.

575540:ISOP RS12585
gene id: 575540:ISOP_RS12585
uniprot id: E8R6K7
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

575540:ISOP RS07885
gene id: 575540:ISOP_RS07885
uniprot id: E8QY72
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS13950
gene id: 575540:ISOP_RS13950
uniprot id: E8QZ37
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

575540:ISOP RS12235
gene id: 575540:ISOP_RS12235
uniprot id: E8R5U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

575540:ISOP RS12450
gene id: 575540:ISOP_RS12450
uniprot id: E8R6I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

575540:ISOP RS16085
gene id: 575540:ISOP_RS16085
uniprot id: E8R2T2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

575540:ISOP RS00560
gene id: 575540:ISOP_RS00560
uniprot id: E8R5G2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

575540:ISOP RS16680
gene id: 575540:ISOP_RS16680
uniprot id: E8R3W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS03510
gene id: 575540:ISOP_RS03510
uniprot id: E8R0R8
names: Similarity
messages: Belongs to the creatininase superfamily.

575540:ISOP RS05480
gene id: 575540:ISOP_RS05480
uniprot id: E8R434
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS15960
gene id: 575540:ISOP_RS15960
uniprot id: E8R2R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

575540:ISOP RS12900
gene id: 575540:ISOP_RS12900
uniprot id: E8QWS9
names: Similarity
messages: Belongs to the CobT family.

575540:ISOP RS14730
gene id: 575540:ISOP_RS14730
uniprot id: E8R0J5
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

575540:ISOP RS09845
gene id: 575540:ISOP_RS09845
uniprot id: E8R1Y0
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

575540:ISOP RS00605
gene id: 575540:ISOP_RS00605
uniprot id: E8R5G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

575540:ISOP RS14290
gene id: 575540:ISOP_RS14290
uniprot id: E8QZV5
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS13625
gene id: 575540:ISOP_RS13625
uniprot id: E8QYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

575540:ISOP RS01080
gene id: 575540:ISOP_RS01080
uniprot id: E8QWA5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

575540:ISOP RS02355
gene id: 575540:ISOP_RS02355
uniprot id: E8QYR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

575540:ISOP RS20275
gene id: 575540:ISOP_RS20275
uniprot id: E8R687
names: Similarity
messages: Belongs to the peptidase S11 family.

575540:ISOP RS15055
gene id: 575540:ISOP_RS15055
uniprot id: E8R134
names: Similarity
messages: Belongs to the GSP E family.

575540:ISOP RS20610
gene id: 575540:ISOP_RS20610
uniprot id: E8R5J2
names: Function
names: Similarity
messages: In the N-terminal section; belongs to the phytochrome family.
messages: Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reductase, rRNA, etc. It also controls the expression of its own gene(s) in a negative feedback fashion.

575540:ISOP RS04695
gene id: 575540:ISOP_RS04695
uniprot id: E8R2X0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS01650
gene id: 575540:ISOP_RS01650
uniprot id: E8QX69
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

575540:ISOP RS18590
gene id: 575540:ISOP_RS18590
uniprot id: E8QWZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

575540:ISOP RS06765
gene id: 575540:ISOP_RS06765
uniprot id: E8R6F6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

575540:ISOP RS05850
gene id: 575540:ISOP_RS05850
uniprot id: E8R4U1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS11225
gene id: 575540:ISOP_RS11225
uniprot id: E8R3T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

575540:ISOP RS20005
gene id: 575540:ISOP_RS20005
uniprot id: E8R011
names: Similarity
messages: Belongs to the pyruvate kinase family.

575540:ISOP RS07740
gene id: 575540:ISOP_RS07740
uniprot id: E8QY44
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

575540:ISOP RS02945
gene id: 575540:ISOP_RS02945
uniprot id: E8R025
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

575540:ISOP RS06380
gene id: 575540:ISOP_RS06380
uniprot id: E8R5N5
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

575540:ISOP RS06225
gene id: 575540:ISOP_RS06225
uniprot id: E8R5K9
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Homodimer.

575540:ISOP RS08365
gene id: 575540:ISOP_RS08365
uniprot id: E8QZL5
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

575540:ISOP RS03090
gene id: 575540:ISOP_RS03090
uniprot id: E8R053
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

575540:ISOP RS04115
gene id: 575540:ISOP_RS04115
uniprot id: E8R1U1
names: Similarity
messages: Belongs to the group II decarboxylase family.

575540:ISOP RS06065
gene id: 575540:ISOP_RS06065
uniprot id: E8R4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

575540:ISOP RS01530
gene id: 575540:ISOP_RS01530
uniprot id: E8QX48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

575540:ISOP RS11240
gene id: 575540:ISOP_RS11240
uniprot id: E8R3T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

575540:ISOP RS09800
gene id: 575540:ISOP_RS09800
uniprot id: E8R1I5
names: Similarity
messages: Belongs to the DprA/Smf family.

575540:ISOP RS09210
gene id: 575540:ISOP_RS09210
uniprot id: E8R0V2
names: Similarity
messages: Belongs to the PstS family.

575540:ISOP RS07770
gene id: 575540:ISOP_RS07770
uniprot id: E8QY50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

575540:ISOP RS15385
gene id: 575540:ISOP_RS15385
uniprot id: E8R1M9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

575540:ISOP RS08385
gene id: 575540:ISOP_RS08385
uniprot id: E8QZL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

575540:ISOP RS05540
gene id: 575540:ISOP_RS05540
uniprot id: E8R445
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

575540:ISOP RS02105
gene id: 575540:ISOP_RS02105
uniprot id: E8QYL5
names: Cofactor
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.

575540:ISOP RS01625
gene id: 575540:ISOP_RS01625
uniprot id: E8QX64
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS13970
gene id: 575540:ISOP_RS13970
uniprot id: E8QZ40
names: Similarity
messages: Belongs to the peptidase C56 family.

575540:ISOP RS22755
gene id: 575540:ISOP_RS22755
uniprot id: E8R583
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

575540:ISOP RS17600
gene id: 575540:ISOP_RS17600
uniprot id: E8R5A8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell inner membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

575540:ISOP RS08690
gene id: 575540:ISOP_RS08690
uniprot id: E8R082
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

575540:ISOP RS13980
gene id: 575540:ISOP_RS13980
uniprot id: E8QZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

575540:ISOP RS09855
gene id: 575540:ISOP_RS09855
uniprot id: E8R1Y2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

575540:ISOP RS16690
gene id: 575540:ISOP_RS16690
uniprot id: E8R3W3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS17605
gene id: 575540:ISOP_RS17605
uniprot id: E8R5A9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

575540:ISOP RS09270
gene id: 575540:ISOP_RS09270
uniprot id: E8R0W2
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

575540:ISOP RS00075
gene id: 575540:ISOP_RS00075
uniprot id: E8R4L9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

575540:ISOP RS15185
gene id: 575540:ISOP_RS15185
uniprot id: E8R1J1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

575540:ISOP RS03120
gene id: 575540:ISOP_RS03120
uniprot id: E8R059
names: Similarity
messages: Belongs to the aspartokinase family.

575540:ISOP RS16450
gene id: 575540:ISOP_RS16450
uniprot id: E8R3D5
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

575540:ISOP RS20545
gene id: 575540:ISOP_RS20545
uniprot id: E8R3K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane

575540:ISOP RS02950
gene id: 575540:ISOP_RS02950
uniprot id: E8R026
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

575540:ISOP RS02045
gene id: 575540:ISOP_RS02045
uniprot id: E8QY01
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS16770
gene id: 575540:ISOP_RS16770
uniprot id: E8R3Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

575540:ISOP RS01465
gene id: 575540:ISOP_RS01465
uniprot id: E8QX36
names: Similarity
messages: Belongs to the peptidase S41A family.

575540:ISOP RS00915
gene id: 575540:ISOP_RS00915
uniprot id: E8R666
names: Similarity
messages: Belongs to the peptidase T1B family. HslV subfamily.

575540:ISOP RS06990
gene id: 575540:ISOP_RS06990
uniprot id: E8QWK8
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

575540:ISOP RS10190
gene id: 575540:ISOP_RS10190
uniprot id: E8R2H6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

575540:ISOP RS15010
gene id: 575540:ISOP_RS15010
uniprot id: E8R126
names: Similarity
messages: Belongs to the PrpD family.

575540:ISOP RS20725
gene id: 575540:ISOP_RS20725
uniprot id: E8QYV5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

575540:ISOP RS08295
gene id: 575540:ISOP_RS08295
uniprot id: E8QZK4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS09830
gene id: 575540:ISOP_RS09830
uniprot id: E8R1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

575540:ISOP RS19015
gene id: 575540:ISOP_RS19015
uniprot id: E8QXS7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

575540:ISOP RS10135
gene id: 575540:ISOP_RS10135
uniprot id: E8R234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

575540:ISOP RS10805
gene id: 575540:ISOP_RS10805
uniprot id: E8R372
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

575540:ISOP RS03625
gene id: 575540:ISOP_RS03625
uniprot id: E8R168
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

575540:ISOP RS01075
gene id: 575540:ISOP_RS01075
uniprot id: E8R696
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

575540:ISOP RS08005
gene id: 575540:ISOP_RS08005
uniprot id: E8QYU9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

575540:ISOP RS17085
gene id: 575540:ISOP_RS17085
uniprot id: E8R4H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

575540:ISOP RS08415
gene id: 575540:ISOP_RS08415
uniprot id: E8QZM6
names: Similarity
messages: Belongs to the DapA family.

575540:ISOP RS15730
gene id: 575540:ISOP_RS15730
uniprot id: E8R283
names: Subcellular Location Annotation
messages: Cytoplasm

575540:ISOP RS13790
gene id: 575540:ISOP_RS13790
uniprot id: E8QZ09
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

575540:ISOP RS09375
gene id: 575540:ISOP_RS09375
uniprot id: E8R0Y2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

575540:ISOP RS17735
gene id: 575540:ISOP_RS17735
uniprot id: E8R5Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

575540:ISOP RS11185
gene id: 575540:ISOP_RS11185
uniprot id: E8R3S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

575540:ISOP RS01145
gene id: 575540:ISOP_RS01145
uniprot id: E8QWC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS00550
gene id: 575540:ISOP_RS00550
uniprot id: E8R5G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

575540:ISOP RS07540
gene id: 575540:ISOP_RS07540
uniprot id: E8QY11
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

575540:ISOP RS06665
gene id: 575540:ISOP_RS06665
uniprot id: E8R6E0
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

575540:ISOP RS00775
gene id: 575540:ISOP_RS00775
uniprot id: E8R640
names: Similarity
messages: Belongs to the GSP E family.

575540:ISOP RS12365
gene id: 575540:ISOP_RS12365
uniprot id: E8R6G6
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS07960
gene id: 575540:ISOP_RS07960
uniprot id: E8QYU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

575540:ISOP RS19115
gene id: 575540:ISOP_RS19115
uniprot id: E8QYE9
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS08015
gene id: 575540:ISOP_RS08015
uniprot id: E8QYV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

575540:ISOP RS02245
gene id: 575540:ISOP_RS02245
uniprot id: E8QYP2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

575540:ISOP RS09280
gene id: 575540:ISOP_RS09280
uniprot id: E8R0W5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

575540:ISOP RS17730
gene id: 575540:ISOP_RS17730
uniprot id: E8R5Y3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS05185
gene id: 575540:ISOP_RS05185
uniprot id: E8R3J8
names: Similarity
messages: Belongs to the peptidase M29 family.

575540:ISOP RS16025
gene id: 575540:ISOP_RS16025
uniprot id: E8R2S0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS08370
gene id: 575540:ISOP_RS08370
uniprot id: E8QZL6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

575540:ISOP RS05660
gene id: 575540:ISOP_RS05660
uniprot id: E8R467
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

575540:ISOP RS15965
gene id: 575540:ISOP_RS15965
uniprot id: E8R2R2
names: Caution
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

575540:ISOP RS07305
gene id: 575540:ISOP_RS07305
uniprot id: E8QXB6
names: Function
names: Similarity
messages: Belongs to the peptidase S46 family.
messages: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.

575540:ISOP RS06535
gene id: 575540:ISOP_RS06535
uniprot id: E8R6B5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

575540:ISOP RS09205
gene id: 575540:ISOP_RS09205
uniprot id: E8R0V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

575540:ISOP RS18585
gene id: 575540:ISOP_RS18585
uniprot id: E8QWZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

575540:ISOP RS19865
gene id: 575540:ISOP_RS19865
uniprot id: E8QZY7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

575540:ISOP RS06500
gene id: 575540:ISOP_RS06500
uniprot id: E8R6A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS00685
gene id: 575540:ISOP_RS00685
uniprot id: E8R5H9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

575540:ISOP RS10735
gene id: 575540:ISOP_RS10735
uniprot id: E8R358
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

575540:ISOP RS16550
gene id: 575540:ISOP_RS16550
uniprot id: E8R3F4
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

575540:ISOP RS03650
gene id: 575540:ISOP_RS03650
uniprot id: E8R173
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell inner membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

575540:ISOP RS00315
gene id: 575540:ISOP_RS00315
uniprot id: E8R5B7
names: Similarity
messages: Belongs to the glutamine synthetase family.

575540:ISOP RS05410
gene id: 575540:ISOP_RS05410
uniprot id: E8R422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

575540:ISOP RS01250
gene id: 575540:ISOP_RS01250
uniprot id: E8QWE1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

575540:ISOP RS18800
gene id: 575540:ISOP_RS18800
uniprot id: E8QXN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

575540:ISOP RS03095
gene id: 575540:ISOP_RS03095
uniprot id: E8R054
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

575540:ISOP RS00735
gene id: 575540:ISOP_RS00735
uniprot id: E8R634
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

575540:ISOP RS15640
gene id: 575540:ISOP_RS15640
uniprot id: E8R264
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS08810
gene id: 575540:ISOP_RS08810
uniprot id: E8R0A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

575540:ISOP RS08700
gene id: 575540:ISOP_RS08700
uniprot id: E8R084
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

575540:ISOP RS11835
gene id: 575540:ISOP_RS11835
uniprot id: E8R522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

575540:ISOP RS01525
gene id: 575540:ISOP_RS01525
uniprot id: E8QX47
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS17415
gene id: 575540:ISOP_RS17415
uniprot id: E8R577
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

575540:ISOP RS09960
gene id: 575540:ISOP_RS09960
uniprot id: E8R202
names: Similarity
messages: Belongs to the heat shock protein 70 family.

575540:ISOP RS18805
gene id: 575540:ISOP_RS18805
uniprot id: E8QXN9
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

575540:ISOP RS14255
gene id: 575540:ISOP_RS14255
uniprot id: E8QZU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

575540:ISOP RS22510
gene id: 575540:ISOP_RS22510
uniprot id: E8QYF8
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS03005
gene id: 575540:ISOP_RS03005
uniprot id: E8R036
names: Cofactor
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.

575540:ISOP RS12495
gene id: 575540:ISOP_RS12495
uniprot id: E8R6J3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS01965
gene id: 575540:ISOP_RS01965
uniprot id: E8QXY5
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS16030
gene id: 575540:ISOP_RS16030
uniprot id: E8R2S1
names: Similarity
messages: Belongs to the peptidase M16 family.

575540:ISOP RS01955
gene id: 575540:ISOP_RS01955
uniprot id: E8QXY3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS12460
gene id: 575540:ISOP_RS12460
uniprot id: E8R6I6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Membrane

575540:ISOP RS05890
gene id: 575540:ISOP_RS05890
uniprot id: E8R4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

575540:ISOP RS17025
gene id: 575540:ISOP_RS17025
uniprot id: E8R4G4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

575540:ISOP RS19610
gene id: 575540:ISOP_RS19610
uniprot id: E8QZ91
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

575540:ISOP RS11440
gene id: 575540:ISOP_RS11440
uniprot id: E8R4A6
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

575540:ISOP RS08280
gene id: 575540:ISOP_RS08280
uniprot id: E8QZ00
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

575540:ISOP RS02955
gene id: 575540:ISOP_RS02955
uniprot id: E8R027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

575540:ISOP RS06300
gene id: 575540:ISOP_RS06300
uniprot id: E8R5M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

575540:ISOP RS06115
gene id: 575540:ISOP_RS06115
uniprot id: E8R5I9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

575540:ISOP RS10130
gene id: 575540:ISOP_RS10130
uniprot id: E8R233
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

575540:ISOP RS03460
gene id: 575540:ISOP_RS03460
uniprot id: E8R0R0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

575540:ISOP RS16700
gene id: 575540:ISOP_RS16700
uniprot id: E8R3W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

575540:ISOP RS20415
gene id: 575540:ISOP_RS20415
uniprot id: E8R0R3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

575540:ISOP RS17185
gene id: 575540:ISOP_RS17185
uniprot id: E8R4J4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

575540:ISOP RS02810
gene id: 575540:ISOP_RS02810
uniprot id: E8QZI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).
messages: Cytoplasm
messages: Homotetramer.

575540:ISOP RS05965
gene id: 575540:ISOP_RS05965
uniprot id: E8R4W3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS02980
gene id: 575540:ISOP_RS02980
uniprot id: E8R032
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell inner membrane
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

575540:ISOP RS13425
gene id: 575540:ISOP_RS13425
uniprot id: E8QY82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

575540:ISOP RS03575
gene id: 575540:ISOP_RS03575
uniprot id: E8R159
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

575540:ISOP RS18605
gene id: 575540:ISOP_RS18605
uniprot id: E8QX01
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS13935
gene id: 575540:ISOP_RS13935
uniprot id: E8QZ34
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

575540:ISOP RS00675
gene id: 575540:ISOP_RS00675
uniprot id: E8R5H7
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

575540:ISOP RS10090
gene id: 575540:ISOP_RS10090
uniprot id: E8R226
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

575540:ISOP RS10595
gene id: 575540:ISOP_RS10595
uniprot id: E8R332
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

575540:ISOP RS01670
gene id: 575540:ISOP_RS01670
uniprot id: E8QX72
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

575540:ISOP RS03775
gene id: 575540:ISOP_RS03775
uniprot id: E8R194
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

575540:ISOP RS10070
gene id: 575540:ISOP_RS10070
uniprot id: E8R222
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS07710
gene id: 575540:ISOP_RS07710
uniprot id: E8QY38
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS07855
gene id: 575540:ISOP_RS07855
uniprot id: E8QY67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

575540:ISOP RS00820
gene id: 575540:ISOP_RS00820
uniprot id: E8R648
names: Similarity
messages: Belongs to the peptidase S1C family.

575540:ISOP RS16510
gene id: 575540:ISOP_RS16510
uniprot id: E8R3E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the R-transferase family. Bpt subfamily.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.

575540:ISOP RS01030
gene id: 575540:ISOP_RS01030
uniprot id: E8R688
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

575540:ISOP RS18240
gene id: 575540:ISOP_RS18240
uniprot id: E8R6S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

575540:ISOP RS11940
gene id: 575540:ISOP_RS11940
uniprot id: E8R540
names: Similarity
messages: Belongs to the phycobiliprotein family.

575540:ISOP RS11465
gene id: 575540:ISOP_RS11465
uniprot id: E8R4B0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

575540:ISOP RS15150
gene id: 575540:ISOP_RS15150
uniprot id: E8R152
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

575540:ISOP RS07935
gene id: 575540:ISOP_RS07935
uniprot id: E8QYT5
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS19425
gene id: 575540:ISOP_RS19425
uniprot id: E8QYK2
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

575540:ISOP RS11090
gene id: 575540:ISOP_RS11090
uniprot id: E8R3Q7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS18635
gene id: 575540:ISOP_RS18635
uniprot id: E8QX07
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

575540:ISOP RS19300
gene id: 575540:ISOP_RS19300
uniprot id: E8QYI0
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS11535
gene id: 575540:ISOP_RS11535
uniprot id: E8R4C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

575540:ISOP RS06140
gene id: 575540:ISOP_RS06140
uniprot id: E8R5J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS16530
gene id: 575540:ISOP_RS16530
uniprot id: E8R3F0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS06820
gene id: 575540:ISOP_RS06820
uniprot id: E8QWH6
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

575540:ISOP RS08240
gene id: 575540:ISOP_RS08240
uniprot id: E8QYZ3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS08665
gene id: 575540:ISOP_RS08665
uniprot id: E8QZR8
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS19460
gene id: 575540:ISOP_RS19460
uniprot id: E8QYK8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

575540:ISOP RS00450
gene id: 575540:ISOP_RS00450
uniprot id: E8R5E1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

575540:ISOP RS09595
gene id: 575540:ISOP_RS09595
uniprot id: E8R1E9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS11305
gene id: 575540:ISOP_RS11305
uniprot id: E8R480
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

575540:ISOP RS09065
gene id: 575540:ISOP_RS09065
uniprot id: E8R0S7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS17855
gene id: 575540:ISOP_RS17855
uniprot id: E8R607
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS10105
gene id: 575540:ISOP_RS10105
uniprot id: E8R230
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

575540:ISOP RS17000
gene id: 575540:ISOP_RS17000
uniprot id: E8R4F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

575540:ISOP RS19525
gene id: 575540:ISOP_RS19525
uniprot id: E8QZ75
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

575540:ISOP RS00025
gene id: 575540:ISOP_RS00025
uniprot id: E8R4L1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

575540:ISOP RS18050
gene id: 575540:ISOP_RS18050
uniprot id: E8R6N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

575540:ISOP RS15355
gene id: 575540:ISOP_RS15355
uniprot id: E8R1M4
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

575540:ISOP RS03265
gene id: 575540:ISOP_RS03265
uniprot id: E8R0L8
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

575540:ISOP RS03380
gene id: 575540:ISOP_RS03380
uniprot id: E8R0P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

575540:ISOP RS09435
gene id: 575540:ISOP_RS09435
uniprot id: E8R1C2
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

575540:ISOP RS03505
gene id: 575540:ISOP_RS03505
uniprot id: E8R0R7
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

575540:ISOP RS20065
gene id: 575540:ISOP_RS20065
uniprot id: E8R6V5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

575540:ISOP RS13275
gene id: 575540:ISOP_RS13275
uniprot id: E8QXK1
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

575540:ISOP RS06025
gene id: 575540:ISOP_RS06025
uniprot id: E8R4X5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

575540:ISOP RS05445
gene id: 575540:ISOP_RS05445
uniprot id: E8R430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

575540:ISOP RS15610
gene id: 575540:ISOP_RS15610
uniprot id: E8R258
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

575540:ISOP RS10830
gene id: 575540:ISOP_RS10830
uniprot id: E8R377
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

575540:ISOP RS03195
gene id: 575540:ISOP_RS03195
uniprot id: E8R072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

575540:ISOP RS14090
gene id: 575540:ISOP_RS14090
uniprot id: E8QZ65
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

575540:ISOP RS02510
gene id: 575540:ISOP_RS02510
uniprot id: E8QZD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS04475
gene id: 575540:ISOP_RS04475
uniprot id: E8R2E8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

575540:ISOP RS07435
gene id: 575540:ISOP_RS07435
uniprot id: E8QXE1
names: Similarity
messages: Belongs to the UxaA family.

575540:ISOP RS18725
gene id: 575540:ISOP_RS18725
uniprot id: E8QX23
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

575540:ISOP RS10165
gene id: 575540:ISOP_RS10165
uniprot id: E8R240
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

575540:ISOP RS19495
gene id: 575540:ISOP_RS19495
uniprot id: E8QZ69
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS05040
gene id: 575540:ISOP_RS05040
uniprot id: E8R3H1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

575540:ISOP RS15855
gene id: 575540:ISOP_RS15855
uniprot id: E8R2A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

575540:ISOP RS09465
gene id: 575540:ISOP_RS09465
uniprot id: E8R1C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

575540:ISOP RS11630
gene id: 575540:ISOP_RS11630
uniprot id: E8R4D9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS02445
gene id: 575540:ISOP_RS02445
uniprot id: E8QYS9
names: Similarity
messages: Belongs to the TrpF family.

575540:ISOP RS14225
gene id: 575540:ISOP_RS14225
uniprot id: E8QZU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

575540:ISOP RS19725
gene id: 575540:ISOP_RS19725
uniprot id: E8QZA8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS08445
gene id: 575540:ISOP_RS08445
uniprot id: E8QZN2
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

575540:ISOP RS08350
gene id: 575540:ISOP_RS08350
uniprot id: E8QZL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

575540:ISOP RS15065
gene id: 575540:ISOP_RS15065
uniprot id: E8R135
names: Similarity
messages: Belongs to the GSP E family.

575540:ISOP RS18090
gene id: 575540:ISOP_RS18090
uniprot id: E8R6P6
names: Similarity
messages: Belongs to the peptidase M16 family.

575540:ISOP RS01590
gene id: 575540:ISOP_RS01590
uniprot id: E8QX58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

575540:ISOP RS13195
gene id: 575540:ISOP_RS13195
uniprot id: E8QXI6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

575540:ISOP RS14605
gene id: 575540:ISOP_RS14605
uniprot id: E8R0H3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS06295
gene id: 575540:ISOP_RS06295
uniprot id: E8R5M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

575540:ISOP RS11260
gene id: 575540:ISOP_RS11260
uniprot id: E8R3T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

575540:ISOP RS11100
gene id: 575540:ISOP_RS11100
uniprot id: E8R3Q9
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS12025
gene id: 575540:ISOP_RS12025
uniprot id: E8R5Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

575540:ISOP RS13745
gene id: 575540:ISOP_RS13745
uniprot id: E8QYE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS16870
gene id: 575540:ISOP_RS16870
uniprot id: E8R3Z9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS12870
gene id: 575540:ISOP_RS12870
uniprot id: E8QWS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

575540:ISOP RS07290
gene id: 575540:ISOP_RS07290
uniprot id: E8QXB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Membrane

575540:ISOP RS06630
gene id: 575540:ISOP_RS06630
uniprot id: E8R6D3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

575540:ISOP RS10055
gene id: 575540:ISOP_RS10055
uniprot id: E8R219
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS09660
gene id: 575540:ISOP_RS09660
uniprot id: E8R1F8
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS18275
gene id: 575540:ISOP_RS18275
uniprot id: E8R6S8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

575540:ISOP RS17885
gene id: 575540:ISOP_RS17885
uniprot id: E8R613
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

575540:ISOP RS08210
gene id: 575540:ISOP_RS08210
uniprot id: E8QYY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

575540:ISOP RS12645
gene id: 575540:ISOP_RS12645
uniprot id: E8R6L9
names: Similarity
messages: Belongs to the RecJ family.

575540:ISOP RS15345
gene id: 575540:ISOP_RS15345
uniprot id: E8R1M2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

575540:ISOP RS03025
gene id: 575540:ISOP_RS03025
uniprot id: E8R040
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

575540:ISOP RS04615
gene id: 575540:ISOP_RS04615
uniprot id: E8R2H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

575540:ISOP RS09360
gene id: 575540:ISOP_RS09360
uniprot id: E8R0X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS08325
gene id: 575540:ISOP_RS08325
uniprot id: E8QZK7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

575540:ISOP RS04160
gene id: 575540:ISOP_RS04160
uniprot id: E8R1V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

575540:ISOP RS21240
gene id: 575540:ISOP_RS21240
uniprot id: E8R1J5
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS07255
gene id: 575540:ISOP_RS07255
uniprot id: E8QXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

575540:ISOP RS20255
gene id: 575540:ISOP_RS20255
uniprot id: E8R637
names: Similarity
messages: Belongs to the peptidase A24 family.

575540:ISOP RS04090
gene id: 575540:ISOP_RS04090
uniprot id: E8R1T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbbQ/NirQ/NorQ/GpvN family.
messages: Vesicle
messages: gas vesicle

575540:ISOP RS15620
gene id: 575540:ISOP_RS15620
uniprot id: E8R260
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

575540:ISOP RS06615
gene id: 575540:ISOP_RS06615
uniprot id: E8R6C9
names: Similarity
messages: Belongs to the hyi family.

575540:ISOP RS19320
gene id: 575540:ISOP_RS19320
uniprot id: E8QYI3
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

575540:ISOP RS17400
gene id: 575540:ISOP_RS17400
uniprot id: E8R574
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell inner membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

575540:ISOP RS18745
gene id: 575540:ISOP_RS18745
uniprot id: E8QXM9
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

575540:ISOP RS20850
gene id: 575540:ISOP_RS20850
uniprot id: E8R1D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

575540:ISOP RS20680
gene id: 575540:ISOP_RS20680
uniprot id: E8QWN7
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14345
gene id: 575540:ISOP_RS14345
uniprot id: E8QZW4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

575540:ISOP RS17570
gene id: 575540:ISOP_RS17570
uniprot id: E8R5A3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

575540:ISOP RS03470
gene id: 575540:ISOP_RS03470
uniprot id: E8R0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

575540:ISOP RS09260
gene id: 575540:ISOP_RS09260
uniprot id: E8R0W0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

575540:ISOP RS20565
gene id: 575540:ISOP_RS20565
uniprot id: E8R420
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

575540:ISOP RS05025
gene id: 575540:ISOP_RS05025
uniprot id: E8R3G9
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

575540:ISOP RS10140
gene id: 575540:ISOP_RS10140
uniprot id: E8R235
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

575540:ISOP RS14000
gene id: 575540:ISOP_RS14000
uniprot id: E8QZ46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

575540:ISOP RS03455
gene id: 575540:ISOP_RS03455
uniprot id: E8R0Q9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS11220
gene id: 575540:ISOP_RS11220
uniprot id: E8R3T0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

575540:ISOP RS16880
gene id: 575540:ISOP_RS16880
uniprot id: E8R402
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

575540:ISOP RS02910
gene id: 575540:ISOP_RS02910
uniprot id: E8R018
names: Similarity
messages: Belongs to the AAA ATPase family.

575540:ISOP RS13995
gene id: 575540:ISOP_RS13995
uniprot id: E8QZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

575540:ISOP RS19825
gene id: 575540:ISOP_RS19825
uniprot id: E8QZC7
names: Similarity
messages: Belongs to the UPF0047 family.

575540:ISOP RS15220
gene id: 575540:ISOP_RS15220
uniprot id: E8R1J8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

575540:ISOP RS14590
gene id: 575540:ISOP_RS14590
uniprot id: E8R0H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

575540:ISOP RS11180
gene id: 575540:ISOP_RS11180
uniprot id: E8R3S2
names: Similarity
messages: Belongs to the LarC family.

575540:ISOP RS16060
gene id: 575540:ISOP_RS16060
uniprot id: E8R2S7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

575540:ISOP RS02120
gene id: 575540:ISOP_RS02120
uniprot id: E8QYL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

575540:ISOP RS16435
gene id: 575540:ISOP_RS16435
uniprot id: E8R3D3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS13890
gene id: 575540:ISOP_RS13890
uniprot id: E8QZ24
names: Similarity
messages: Belongs to the TPP enzyme family.

575540:ISOP RS17785
gene id: 575540:ISOP_RS17785
uniprot id: E8R5Z4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS14350
gene id: 575540:ISOP_RS14350
uniprot id: E8QZW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

575540:ISOP RS07745
gene id: 575540:ISOP_RS07745
uniprot id: E8QY45
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

575540:ISOP RS05620
gene id: 575540:ISOP_RS05620
uniprot id: E8R460
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14375
gene id: 575540:ISOP_RS14375
uniprot id: E8QZW9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

575540:ISOP RS01190
gene id: 575540:ISOP_RS01190
uniprot id: E8QWC9
names: Similarity
messages: Belongs to the heat shock protein 90 family.

575540:ISOP RS01885
gene id: 575540:ISOP_RS01885
uniprot id: E8QXW9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

575540:ISOP RS00310
gene id: 575540:ISOP_RS00310
uniprot id: E8R5B6
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

575540:ISOP RS15995
gene id: 575540:ISOP_RS15995
uniprot id: E8R2R7
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

575540:ISOP RS04625
gene id: 575540:ISOP_RS04625
uniprot id: E8R2V7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell inner membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

575540:ISOP RS05610
gene id: 575540:ISOP_RS05610
uniprot id: E8R458
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

575540:ISOP RS18785
gene id: 575540:ISOP_RS18785
uniprot id: E8QXN5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

575540:ISOP RS08400
gene id: 575540:ISOP_RS08400
uniprot id: E8QZM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

575540:ISOP RS02870
gene id: 575540:ISOP_RS02870
uniprot id: E8QZK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

575540:ISOP RS09035
gene id: 575540:ISOP_RS09035
uniprot id: E8R0E0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

575540:ISOP RS17420
gene id: 575540:ISOP_RS17420
uniprot id: E8R578
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

575540:ISOP RS16620
gene id: 575540:ISOP_RS16620
uniprot id: E8R3V0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

575540:ISOP RS18995
gene id: 575540:ISOP_RS18995
uniprot id: E8QXS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

575540:ISOP RS19505
gene id: 575540:ISOP_RS19505
uniprot id: E8QZ71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

575540:ISOP RS20445
gene id: 575540:ISOP_RS20445
uniprot id: E8R1T1
names: Function
names: Subcellular Location Annotation
messages: May play a structural or regulatory role in gas vesicle synthesis.
messages: Vesicle
messages: gas vesicle

575540:ISOP RS17615
gene id: 575540:ISOP_RS17615
uniprot id: E8R5B1
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS16100
gene id: 575540:ISOP_RS16100
uniprot id: E8R2T5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS02780
gene id: 575540:ISOP_RS02780
uniprot id: E8QZI4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

575540:ISOP RS15045
gene id: 575540:ISOP_RS15045
uniprot id: E8R132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

575540:ISOP RS02730
gene id: 575540:ISOP_RS02730
uniprot id: E8QZH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

575540:ISOP RS01430
gene id: 575540:ISOP_RS01430
uniprot id: E8QX30
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

575540:ISOP RS14680
gene id: 575540:ISOP_RS14680
uniprot id: E8R0I6
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

575540:ISOP RS06645
gene id: 575540:ISOP_RS06645
uniprot id: E8R6D6
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS04030
gene id: 575540:ISOP_RS04030
uniprot id: E8R1S5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

575540:ISOP RS11790
gene id: 575540:ISOP_RS11790
uniprot id: E8R513
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

575540:ISOP RS16800
gene id: 575540:ISOP_RS16800
uniprot id: E8R3Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

575540:ISOP RS20035
gene id: 575540:ISOP_RS20035
uniprot id: E8R6U8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS11570
gene id: 575540:ISOP_RS11570
uniprot id: E8R4C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

575540:ISOP RS02735
gene id: 575540:ISOP_RS02735
uniprot id: E8QZH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

575540:ISOP RS03105
gene id: 575540:ISOP_RS03105
uniprot id: E8R056
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

575540:ISOP RS11130
gene id: 575540:ISOP_RS11130
uniprot id: E8R3R3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

575540:ISOP RS09390
gene id: 575540:ISOP_RS09390
uniprot id: E8R0Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

575540:ISOP RS15635
gene id: 575540:ISOP_RS15635
uniprot id: E8R263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

575540:ISOP RS02395
gene id: 575540:ISOP_RS02395
uniprot id: E8QYR9
names: Similarity
messages: Belongs to the fabD family.

575540:ISOP RS03995
gene id: 575540:ISOP_RS03995
uniprot id: E8R1R8
names: Similarity
messages: Belongs to the Skp family.

575540:ISOP RS01095
gene id: 575540:ISOP_RS01095
uniprot id: E8QWA8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS10395
gene id: 575540:ISOP_RS10395
uniprot id: E8R2L4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

575540:ISOP RS08050
gene id: 575540:ISOP_RS08050
uniprot id: E8QYV8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

575540:ISOP RS15490
gene id: 575540:ISOP_RS15490
uniprot id: E8R1P8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS16090
gene id: 575540:ISOP_RS16090
uniprot id: E8R2T3
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

575540:ISOP RS19490
gene id: 575540:ISOP_RS19490
uniprot id: E8QZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

575540:ISOP RS02205
gene id: 575540:ISOP_RS02205
uniprot id: E8QYN5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

575540:ISOP RS15075
gene id: 575540:ISOP_RS15075
uniprot id: E8R137
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

575540:ISOP RS15155
gene id: 575540:ISOP_RS15155
uniprot id: E8R153
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

575540:ISOP RS16760
gene id: 575540:ISOP_RS16760
uniprot id: E8R3X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

575540:ISOP RS19485
gene id: 575540:ISOP_RS19485
uniprot id: E8QYL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

575540:ISOP RS05990
gene id: 575540:ISOP_RS05990
uniprot id: E8R4W8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

575540:ISOP RS12885
gene id: 575540:ISOP_RS12885
uniprot id: E8QWS6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

575540:ISOP RS10345
gene id: 575540:ISOP_RS10345
uniprot id: E8R2K4
names: Similarity
messages: Belongs to the citrate synthase family.

575540:ISOP RS06120
gene id: 575540:ISOP_RS06120
uniprot id: E8R5J0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS14400
gene id: 575540:ISOP_RS14400
uniprot id: E8QZX4
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

575540:ISOP RS04690
gene id: 575540:ISOP_RS04690
uniprot id: E8R2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

575540:ISOP RS08670
gene id: 575540:ISOP_RS08670
uniprot id: E8R078
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS00185
gene id: 575540:ISOP_RS00185
uniprot id: E8R4P3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

575540:ISOP RS02925
gene id: 575540:ISOP_RS02925
uniprot id: E8R021
names: Similarity
messages: Belongs to the LOG family.

575540:ISOP RS10865
gene id: 575540:ISOP_RS10865
uniprot id: E8R384
names: Similarity
messages: Belongs to the ALAD family.

575540:ISOP RS02965
gene id: 575540:ISOP_RS02965
uniprot id: E8R029
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell inner membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

575540:ISOP RS07695
gene id: 575540:ISOP_RS07695
uniprot id: E8QY35
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

575540:ISOP RS03565
gene id: 575540:ISOP_RS03565
uniprot id: E8R157
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell inner membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

575540:ISOP RS15605
gene id: 575540:ISOP_RS15605
uniprot id: E8R257
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

575540:ISOP RS00030
gene id: 575540:ISOP_RS00030
uniprot id: E8R4L2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS08030
gene id: 575540:ISOP_RS08030
uniprot id: E8QYV4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS16555
gene id: 575540:ISOP_RS16555
uniprot id: E8R3F6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

575540:ISOP RS15675
gene id: 575540:ISOP_RS15675
uniprot id: E8R272
names: Similarity
messages: In the N-terminal section; belongs to the phytochrome family.

575540:ISOP RS05775
gene id: 575540:ISOP_RS05775
uniprot id: E8R4T0
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

575540:ISOP RS20410
gene id: 575540:ISOP_RS20410
uniprot id: E8R0Q7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

575540:ISOP RS20575
gene id: 575540:ISOP_RS20575
uniprot id: E8R439
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS02390
gene id: 575540:ISOP_RS02390
uniprot id: E8QYR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

575540:ISOP RS11335
gene id: 575540:ISOP_RS11335
uniprot id: E8R486
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

575540:ISOP RS16290
gene id: 575540:ISOP_RS16290
uniprot id: E8R3A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

575540:ISOP RS10535
gene id: 575540:ISOP_RS10535
uniprot id: E8R2N9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

575540:ISOP RS04855
gene id: 575540:ISOP_RS04855
uniprot id: E8R300
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS05525
gene id: 575540:ISOP_RS05525
uniprot id: E8R443
names: Similarity
messages: Belongs to the heat shock protein 70 family.

575540:ISOP RS02060
gene id: 575540:ISOP_RS02060
uniprot id: E8QY04
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

575540:ISOP RS01950
gene id: 575540:ISOP_RS01950
uniprot id: E8QXY2
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS07215
gene id: 575540:ISOP_RS07215
uniprot id: E8QX99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

575540:ISOP RS17065
gene id: 575540:ISOP_RS17065
uniprot id: E8R4H2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

575540:ISOP RS20580
gene id: 575540:ISOP_RS20580
uniprot id: E8R461
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS16045
gene id: 575540:ISOP_RS16045
uniprot id: E8R2S4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

575540:ISOP RS15200
gene id: 575540:ISOP_RS15200
uniprot id: E8R1J4
names: Similarity
messages: Belongs to the peptidase M29 family.

575540:ISOP RS07200
gene id: 575540:ISOP_RS07200
uniprot id: E8QX96
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

575540:ISOP RS13865
gene id: 575540:ISOP_RS13865
uniprot id: E8QZ18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

575540:ISOP RS03850
gene id: 575540:ISOP_RS03850
uniprot id: E8R1A8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

575540:ISOP RS00180
gene id: 575540:ISOP_RS00180
uniprot id: E8R4P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

575540:ISOP RS11325
gene id: 575540:ISOP_RS11325
uniprot id: E8R484
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

575540:ISOP RS18565
gene id: 575540:ISOP_RS18565
uniprot id: E8QWZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Membrane

575540:ISOP RS07860
gene id: 575540:ISOP_RS07860
uniprot id: E8QY68
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

575540:ISOP RS05240
gene id: 575540:ISOP_RS05240
uniprot id: E8R3L0
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

575540:ISOP RS06855
gene id: 575540:ISOP_RS06855
uniprot id: E8QWI2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

575540:ISOP RS23275
gene id: 575540:ISOP_RS23275
uniprot id: E8QYR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

575540:ISOP RS11315
gene id: 575540:ISOP_RS11315
uniprot id: E8R482
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

575540:ISOP RS09605
gene id: 575540:ISOP_RS09605
uniprot id: E8R1F1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

575540:ISOP RS04820
gene id: 575540:ISOP_RS04820
uniprot id: E8R2Z4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

575540:ISOP RS04560
gene id: 575540:ISOP_RS04560
uniprot id: E8R2G4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS15670
gene id: 575540:ISOP_RS15670
uniprot id: E8R270
names: Similarity
messages: Belongs to the AOR/FOR family.

575540:ISOP RS00580
gene id: 575540:ISOP_RS00580
uniprot id: E8R5G5
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

575540:ISOP RS01425
gene id: 575540:ISOP_RS01425
uniprot id: E8QX29
names: Similarity
messages: Belongs to the UPF0235 family.

575540:ISOP RS17435
gene id: 575540:ISOP_RS17435
uniprot id: E8R581
names: Cofactor
messages: Binds 1 zinc ion per subunit.

575540:ISOP RS13570
gene id: 575540:ISOP_RS13570
uniprot id: E8QYB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

575540:ISOP RS03765
gene id: 575540:ISOP_RS03765
uniprot id: E8R193
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

575540:ISOP RS17550
gene id: 575540:ISOP_RS17550
uniprot id: E8R5A0
names: Similarity
messages: Belongs to the pyruvoyl-dependent arginine decarboxylase family.

575540:ISOP RS02715
gene id: 575540:ISOP_RS02715
uniprot id: E8QZH4
names: Similarity
messages: Belongs to the asparagine synthetase family.

575540:ISOP RS19055
gene id: 575540:ISOP_RS19055
uniprot id: E8QXT4
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

575540:ISOP RS05800
gene id: 575540:ISOP_RS05800
uniprot id: E8R4T4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

575540:ISOP RS15495
gene id: 575540:ISOP_RS15495
uniprot id: E8R1P9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

575540:ISOP RS09200
gene id: 575540:ISOP_RS09200
uniprot id: E8R0V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

575540:ISOP RS19895
gene id: 575540:ISOP_RS19895
uniprot id: E8QZZ2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

575540:ISOP RS15050
gene id: 575540:ISOP_RS15050
uniprot id: E8R133
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

575540:ISOP RS11690
gene id: 575540:ISOP_RS11690
uniprot id: E8R4Z5
names: Function
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

575540:ISOP RS16670
gene id: 575540:ISOP_RS16670
uniprot id: E8R3V9
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

575540:ISOP RS11390
gene id: 575540:ISOP_RS11390
uniprot id: E8R497
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS18155
gene id: 575540:ISOP_RS18155
uniprot id: E8R6Q8
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

575540:ISOP RS07210
gene id: 575540:ISOP_RS07210
uniprot id: E8QX98
names: Function
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

575540:ISOP RS12265
gene id: 575540:ISOP_RS12265
uniprot id: E8R5V1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS15140
gene id: 575540:ISOP_RS15140
uniprot id: E8R150
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

575540:ISOP RS15690
gene id: 575540:ISOP_RS15690
uniprot id: E8R277
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS21220
gene id: 575540:ISOP_RS21220
uniprot id: E8R123
names: Similarity
messages: Belongs to the AB hydrolase superfamily.

575540:ISOP RS09075
gene id: 575540:ISOP_RS09075
uniprot id: E8R0S9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

575540:ISOP RS05920
gene id: 575540:ISOP_RS05920
uniprot id: E8R4V4
names: Similarity
messages: Belongs to the archease family.

575540:ISOP RS17180
gene id: 575540:ISOP_RS17180
uniprot id: E8R4J3
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

575540:ISOP RS00275
gene id: 575540:ISOP_RS00275
uniprot id: E8R4R0
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14340
gene id: 575540:ISOP_RS14340
uniprot id: E8QZW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

575540:ISOP RS17150
gene id: 575540:ISOP_RS17150
uniprot id: E8R4I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

575540:ISOP RS12335
gene id: 575540:ISOP_RS12335
uniprot id: E8R5W3
names: Similarity
messages: Belongs to the peptidase S9A family.

575540:ISOP RS11295
gene id: 575540:ISOP_RS11295
uniprot id: E8R479
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

575540:ISOP RS04105
gene id: 575540:ISOP_RS04105
uniprot id: E8R1T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gas vesicle protein type A family.
messages: Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.
messages: gas vesicle membrane

575540:ISOP RS00460
gene id: 575540:ISOP_RS00460
uniprot id: E8R5E2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

575540:ISOP RS05755
gene id: 575540:ISOP_RS05755
uniprot id: E8R4S6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS19730
gene id: 575540:ISOP_RS19730
uniprot id: E8QZA9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

575540:ISOP RS08175
gene id: 575540:ISOP_RS08175
uniprot id: E8QYY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

575540:ISOP RS04610
gene id: 575540:ISOP_RS04610
uniprot id: E8R2H3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

575540:ISOP RS02440
gene id: 575540:ISOP_RS02440
uniprot id: E8QYS8
names: Similarity
messages: Belongs to the thioredoxin family.

575540:ISOP RS11095
gene id: 575540:ISOP_RS11095
uniprot id: E8R3Q8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS02485
gene id: 575540:ISOP_RS02485
uniprot id: E8QZD5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS19830
gene id: 575540:ISOP_RS19830
uniprot id: E8QZC8
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

575540:ISOP RS02255
gene id: 575540:ISOP_RS02255
uniprot id: E8QYP4
names: Similarity
messages: Belongs to the AAA ATPase family.

575540:ISOP RS01940
gene id: 575540:ISOP_RS01940
uniprot id: E8QXY0
names: Similarity
messages: Belongs to the FrhG family.

575540:ISOP RS18055
gene id: 575540:ISOP_RS18055
uniprot id: E8R6N9
names: Similarity
messages: Belongs to the peptidase C56 family.

575540:ISOP RS07600
gene id: 575540:ISOP_RS07600
uniprot id: E8QY19
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS08485
gene id: 575540:ISOP_RS08485
uniprot id: E8QZP0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

575540:ISOP RS16780
gene id: 575540:ISOP_RS16780
uniprot id: E8R3Y2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

575540:ISOP RS19710
gene id: 575540:ISOP_RS19710
uniprot id: E8QZA6
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS03190
gene id: 575540:ISOP_RS03190
uniprot id: E8R071
names: Subcellular Location Annotation
messages: Periplasm

575540:ISOP RS08275
gene id: 575540:ISOP_RS08275
uniprot id: E8QYZ9
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

575540:ISOP RS19650
gene id: 575540:ISOP_RS19650
uniprot id: E8QZ96
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

575540:ISOP RS21050
gene id: 575540:ISOP_RS21050
uniprot id: E8R6J8
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS06810
gene id: 575540:ISOP_RS06810
uniprot id: E8QWH4
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

575540:ISOP RS11230
gene id: 575540:ISOP_RS11230
uniprot id: E8R3T2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

575540:ISOP RS12445
gene id: 575540:ISOP_RS12445
uniprot id: E8R6I3
names: Similarity
messages: Belongs to the asparagine synthetase family.

575540:ISOP RS09875
gene id: 575540:ISOP_RS09875
uniprot id: E8R1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

575540:ISOP RS03655
gene id: 575540:ISOP_RS03655
uniprot id: E8R174
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS03550
gene id: 575540:ISOP_RS03550
uniprot id: E8R0S5
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

575540:ISOP RS14025
gene id: 575540:ISOP_RS14025
uniprot id: E8QZ51
names: Similarity
messages: Belongs to the peptidase S41A family.

575540:ISOP RS12690
gene id: 575540:ISOP_RS12690
uniprot id: E8R6M8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

575540:ISOP RS08505
gene id: 575540:ISOP_RS08505
uniprot id: E8QZP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

575540:ISOP RS14740
gene id: 575540:ISOP_RS14740
uniprot id: E8R0J7
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS17220
gene id: 575540:ISOP_RS17220
uniprot id: E8R4K0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

575540:ISOP RS08470
gene id: 575540:ISOP_RS08470
uniprot id: E8QZN7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

575540:ISOP RS01770
gene id: 575540:ISOP_RS01770
uniprot id: E8QXU5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

575540:ISOP RS04985
gene id: 575540:ISOP_RS04985
uniprot id: E8R3G2
names: Similarity
messages: Belongs to the HY2 family.

575540:ISOP RS02280
gene id: 575540:ISOP_RS02280
uniprot id: E8QYP8
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS05560
gene id: 575540:ISOP_RS05560
uniprot id: E8R449
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

575540:ISOP RS01180
gene id: 575540:ISOP_RS01180
uniprot id: E8QWC7
names: Similarity
messages: Belongs to the peptidase S49 family.

575540:ISOP RS05870
gene id: 575540:ISOP_RS05870
uniprot id: E8R4U5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

575540:ISOP RS02860
gene id: 575540:ISOP_RS02860
uniprot id: E8QZJ9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

575540:ISOP RS06580
gene id: 575540:ISOP_RS06580
uniprot id: E8R6C2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

575540:ISOP RS00875
gene id: 575540:ISOP_RS00875
uniprot id: E8R658
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

575540:ISOP RS05630
gene id: 575540:ISOP_RS05630
uniprot id: E8R462
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS11235
gene id: 575540:ISOP_RS11235
uniprot id: E8R3T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

575540:ISOP RS15745
gene id: 575540:ISOP_RS15745
uniprot id: E8R285
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS08420
gene id: 575540:ISOP_RS08420
uniprot id: E8QZM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

575540:ISOP RS05710
gene id: 575540:ISOP_RS05710
uniprot id: E8R4R8
names: Similarity
messages: Belongs to the ParB family.

575540:ISOP RS14665
gene id: 575540:ISOP_RS14665
uniprot id: E8R0I3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

575540:ISOP RS10770
gene id: 575540:ISOP_RS10770
uniprot id: E8R365
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

575540:ISOP RS16255
gene id: 575540:ISOP_RS16255
uniprot id: E8R399
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS14930
gene id: 575540:ISOP_RS14930
uniprot id: E8R111
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

575540:ISOP RS05725
gene id: 575540:ISOP_RS05725
uniprot id: E8R4S1
names: Similarity
messages: Belongs to the peptidase S41A family.

575540:ISOP RS20520
gene id: 575540:ISOP_RS20520
uniprot id: E8R3H5
names: Similarity
messages: Belongs to the peptidase S8 family.

575540:ISOP RS16280
gene id: 575540:ISOP_RS16280
uniprot id: E8R3A5
names: Caution
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS01160
gene id: 575540:ISOP_RS01160
uniprot id: E8QWC3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

575540:ISOP RS04235
gene id: 575540:ISOP_RS04235
uniprot id: E8R1W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabB family.
messages: Cell inner membrane
messages: Forms a complex with DabA.
messages: Membrane
messages: Part of an energy-coupled inorganic carbon pump.

575540:ISOP RS12255
gene id: 575540:ISOP_RS12255
uniprot id: E8R5U9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

575540:ISOP RS12790
gene id: 575540:ISOP_RS12790
uniprot id: E8QWR1
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS11310
gene id: 575540:ISOP_RS11310
uniprot id: E8R481
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

575540:ISOP RS07285
gene id: 575540:ISOP_RS07285
uniprot id: E8QXB2
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

575540:ISOP RS04470
gene id: 575540:ISOP_RS04470
uniprot id: E8R2E7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

575540:ISOP RS07755
gene id: 575540:ISOP_RS07755
uniprot id: E8QY47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

575540:ISOP RS06595
gene id: 575540:ISOP_RS06595
uniprot id: E8R6C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

575540:ISOP RS06235
gene id: 575540:ISOP_RS06235
uniprot id: E8R5L1
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

575540:ISOP RS00890
gene id: 575540:ISOP_RS00890
uniprot id: E8R661
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

575540:ISOP RS19240
gene id: 575540:ISOP_RS19240
uniprot id: E8QYG9
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS01510
gene id: 575540:ISOP_RS01510
uniprot id: E8QX44
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

575540:ISOP RS18025
gene id: 575540:ISOP_RS18025
uniprot id: E8R6N5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

575540:ISOP RS14450
gene id: 575540:ISOP_RS14450
uniprot id: E8QZY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

575540:ISOP RS08495
gene id: 575540:ISOP_RS08495
uniprot id: E8QZP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

575540:ISOP RS19515
gene id: 575540:ISOP_RS19515
uniprot id: E8QZ73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

575540:ISOP RS11340
gene id: 575540:ISOP_RS11340
uniprot id: E8R487
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

575540:ISOP RS08025
gene id: 575540:ISOP_RS08025
uniprot id: E8QYV3
names: Similarity
messages: Belongs to the SUI1 family.

575540:ISOP RS17290
gene id: 575540:ISOP_RS17290
uniprot id: E8R554
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS11205
gene id: 575540:ISOP_RS11205
uniprot id: E8R3S7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

575540:ISOP RS08390
gene id: 575540:ISOP_RS08390
uniprot id: E8QZM0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

575540:ISOP RS13485
gene id: 575540:ISOP_RS13485
uniprot id: E8QY95
names: Similarity
messages: Belongs to the peptidase S26 family.

575540:ISOP RS07365
gene id: 575540:ISOP_RS07365
uniprot id: E8QXC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

575540:ISOP RS01235
gene id: 575540:ISOP_RS01235
uniprot id: E8QWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

575540:ISOP RS12455
gene id: 575540:ISOP_RS12455
uniprot id: E8R6I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

575540:ISOP RS11915
gene id: 575540:ISOP_RS11915
uniprot id: E8R535
names: Similarity
messages: Belongs to the glutamate synthase family.

575540:ISOP RS01720
gene id: 575540:ISOP_RS01720
uniprot id: E8QX81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

575540:ISOP RS19655
gene id: 575540:ISOP_RS19655
uniprot id: E8QZ97
names: Similarity
messages: Belongs to the TrpC family.

575540:ISOP RS14595
gene id: 575540:ISOP_RS14595
uniprot id: E8R0H1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

575540:ISOP RS02540
gene id: 575540:ISOP_RS02540
uniprot id: E8QZE5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

575540:ISOP RS14005
gene id: 575540:ISOP_RS14005
uniprot id: E8QZ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

575540:ISOP RS14510
gene id: 575540:ISOP_RS14510
uniprot id: E8R0F5
names: Similarity
messages: Belongs to the ycf81 family.

575540:ISOP RS01240
gene id: 575540:ISOP_RS01240
uniprot id: E8QWD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS16110
gene id: 575540:ISOP_RS16110
uniprot id: E8R2T7
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS00730
gene id: 575540:ISOP_RS00730
uniprot id: E8R633
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

575540:ISOP RS00060
gene id: 575540:ISOP_RS00060
uniprot id: E8R4L7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

575540:ISOP RS17360
gene id: 575540:ISOP_RS17360
uniprot id: E8R568
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS11210
gene id: 575540:ISOP_RS11210
uniprot id: E8R3S8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

575540:ISOP RS11040
gene id: 575540:ISOP_RS11040
uniprot id: E8R3P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell inner membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

575540:ISOP RS06215
gene id: 575540:ISOP_RS06215
uniprot id: E8R5K7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

575540:ISOP RS03225
gene id: 575540:ISOP_RS03225
uniprot id: E8R0L1
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

575540:ISOP RS09910
gene id: 575540:ISOP_RS09910
uniprot id: E8R1Z2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS01340
gene id: 575540:ISOP_RS01340
uniprot id: E8QWF9
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

575540:ISOP RS06540
gene id: 575540:ISOP_RS06540
uniprot id: E8R6B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

575540:ISOP RS16275
gene id: 575540:ISOP_RS16275
uniprot id: E8R3A4
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS18335
gene id: 575540:ISOP_RS18335
uniprot id: E8R6T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm

575540:ISOP RS08885
gene id: 575540:ISOP_RS08885
uniprot id: E8R0B4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

575540:ISOP RS18290
gene id: 575540:ISOP_RS18290
uniprot id: E8R6T1
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS01480
gene id: 575540:ISOP_RS01480
uniprot id: E8QX39
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

575540:ISOP RS14600
gene id: 575540:ISOP_RS14600
uniprot id: E8R0H2
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS20240
gene id: 575540:ISOP_RS20240
uniprot id: E8R5H6
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS06190
gene id: 575540:ISOP_RS06190
uniprot id: E8R5K2
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

575540:ISOP RS11070
gene id: 575540:ISOP_RS11070
uniprot id: E8R3Q4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

575540:ISOP RS12045
gene id: 575540:ISOP_RS12045
uniprot id: E8R5R0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

575540:ISOP RS01805
gene id: 575540:ISOP_RS01805
uniprot id: E8QXV3
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS04415
gene id: 575540:ISOP_RS04415
uniprot id: E8R2D7
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS00510
gene id: 575540:ISOP_RS00510
uniprot id: E8R5F2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

575540:ISOP RS19295
gene id: 575540:ISOP_RS19295
uniprot id: E8QYH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

575540:ISOP RS19010
gene id: 575540:ISOP_RS19010
uniprot id: E8QXS6
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

575540:ISOP RS08140
gene id: 575540:ISOP_RS08140
uniprot id: E8QYX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

575540:ISOP RS22625
gene id: 575540:ISOP_RS22625
uniprot id: E8QZR7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

575540:ISOP RS06490
gene id: 575540:ISOP_RS06490
uniprot id: E8R6A6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

575540:ISOP RS06750
gene id: 575540:ISOP_RS06750
uniprot id: E8R6F4
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

575540:ISOP RS20495
gene id: 575540:ISOP_RS20495
uniprot id: E8R2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS00370
gene id: 575540:ISOP_RS00370
uniprot id: E8R5C6
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

575540:ISOP RS12415
gene id: 575540:ISOP_RS12415
uniprot id: E8R6H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

575540:ISOP RS03555
gene id: 575540:ISOP_RS03555
uniprot id: E8R155
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

575540:ISOP RS02960
gene id: 575540:ISOP_RS02960
uniprot id: E8R028
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell inner membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

575540:ISOP RS06590
gene id: 575540:ISOP_RS06590
uniprot id: E8R6C4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

575540:ISOP RS14030
gene id: 575540:ISOP_RS14030
uniprot id: E8QZ52
names: Similarity
messages: Belongs to the peptidase S41A family.

575540:ISOP RS05980
gene id: 575540:ISOP_RS05980
uniprot id: E8R4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

575540:ISOP RS01380
gene id: 575540:ISOP_RS01380
uniprot id: E8QWG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

575540:ISOP RS07980
gene id: 575540:ISOP_RS07980
uniprot id: E8QYU4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

575540:ISOP RS15135
gene id: 575540:ISOP_RS15135
uniprot id: E8R149
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

575540:ISOP RS11320
gene id: 575540:ISOP_RS11320
uniprot id: E8R483
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

575540:ISOP RS15300
gene id: 575540:ISOP_RS15300
uniprot id: E8R1L4
names: Similarity
messages: Belongs to the DSD1 family.

575540:ISOP RS18720
gene id: 575540:ISOP_RS18720
uniprot id: E8QX22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

575540:ISOP RS05440
gene id: 575540:ISOP_RS05440
uniprot id: E8R429
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

575540:ISOP RS20720
gene id: 575540:ISOP_RS20720
uniprot id: E8QYV2
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS01740
gene id: 575540:ISOP_RS01740
uniprot id: E8QX85
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

575540:ISOP RS07450
gene id: 575540:ISOP_RS07450
uniprot id: E8QXE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

575540:ISOP RS07950
gene id: 575540:ISOP_RS07950
uniprot id: E8QYT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

575540:ISOP RS17045
gene id: 575540:ISOP_RS17045
uniprot id: E8R4G8
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS21555
gene id: 575540:ISOP_RS21555
uniprot id: E8QZB6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

575540:ISOP RS17090
gene id: 575540:ISOP_RS17090
uniprot id: E8R4H7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

575540:ISOP RS07240
gene id: 575540:ISOP_RS07240
uniprot id: E8QXA4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

575540:ISOP RS03140
gene id: 575540:ISOP_RS03140
uniprot id: E8R062
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS00780
gene id: 575540:ISOP_RS00780
uniprot id: E8R641
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS15575
gene id: 575540:ISOP_RS15575
uniprot id: E8R251
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS05420
gene id: 575540:ISOP_RS05420
uniprot id: E8R424
names: Similarity
messages: Belongs to the GSP E family.

575540:ISOP RS02580
gene id: 575540:ISOP_RS02580
uniprot id: E8QZF1
names: Similarity
messages: Belongs to the Dps family.

575540:ISOP RS00970
gene id: 575540:ISOP_RS00970
uniprot id: E8R677
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS05535
gene id: 575540:ISOP_RS05535
uniprot id: E8R444
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS00570
gene id: 575540:ISOP_RS00570
uniprot id: E8R5G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

575540:ISOP RS14410
gene id: 575540:ISOP_RS14410
uniprot id: E8QZX6
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

575540:ISOP RS11600
gene id: 575540:ISOP_RS11600
uniprot id: E8R4D3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14475
gene id: 575540:ISOP_RS14475
uniprot id: E8R0E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

575540:ISOP RS13985
gene id: 575540:ISOP_RS13985
uniprot id: E8QZ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

575540:ISOP RS15370
gene id: 575540:ISOP_RS15370
uniprot id: E8R1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

575540:ISOP RS18530
gene id: 575540:ISOP_RS18530
uniprot id: E8QWY6
names: Caution
names: Function
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS14920
gene id: 575540:ISOP_RS14920
uniprot id: E8R109
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

575540:ISOP RS15970
gene id: 575540:ISOP_RS15970
uniprot id: E8R2R3
names: Similarity
messages: Belongs to the sigma-54 factor family.

575540:ISOP RS00490
gene id: 575540:ISOP_RS00490
uniprot id: E8R5E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

575540:ISOP RS13270
gene id: 575540:ISOP_RS13270
uniprot id: E8QXK0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS03580
gene id: 575540:ISOP_RS03580
uniprot id: E8R160
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

575540:ISOP RS09550
gene id: 575540:ISOP_RS09550
uniprot id: E8R1E2
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

575540:ISOP RS02775
gene id: 575540:ISOP_RS02775
uniprot id: E8QZI3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

575540:ISOP RS14100
gene id: 575540:ISOP_RS14100
uniprot id: E8QZ67
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

575540:ISOP RS05305
gene id: 575540:ISOP_RS05305
uniprot id: E8R3M3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

575540:ISOP RS03620
gene id: 575540:ISOP_RS03620
uniprot id: E8R167
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

575540:ISOP RS17830
gene id: 575540:ISOP_RS17830
uniprot id: E8R602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

575540:ISOP RS09285
gene id: 575540:ISOP_RS09285
uniprot id: E8R0W6
names: Similarity
messages: Belongs to the UPF0145 family.

575540:ISOP RS15190
gene id: 575540:ISOP_RS15190
uniprot id: E8R1J2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS16525
gene id: 575540:ISOP_RS16525
uniprot id: E8R3E9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS14865
gene id: 575540:ISOP_RS14865
uniprot id: E8R0Z8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

575540:ISOP RS09985
gene id: 575540:ISOP_RS09985
uniprot id: E8R206
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

575540:ISOP RS09690
gene id: 575540:ISOP_RS09690
uniprot id: E8R1G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: Membrane

575540:ISOP RS05055
gene id: 575540:ISOP_RS05055
uniprot id: E8R3H4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

575540:ISOP RS01420
gene id: 575540:ISOP_RS01420
uniprot id: E8QX28
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

575540:ISOP RS01810
gene id: 575540:ISOP_RS01810
uniprot id: E8QXV4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

575540:ISOP RS15435
gene id: 575540:ISOP_RS15435
uniprot id: E8R1N7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS03900
gene id: 575540:ISOP_RS03900
uniprot id: E8R1B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

575540:ISOP RS03740
gene id: 575540:ISOP_RS03740
uniprot id: E8R189
names: Similarity
messages: Belongs to the glutamine synthetase family.

575540:ISOP RS15815
gene id: 575540:ISOP_RS15815
uniprot id: E8R2A0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

575540:ISOP RS09040
gene id: 575540:ISOP_RS09040
uniprot id: E8R0E1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

575540:ISOP RS07315
gene id: 575540:ISOP_RS07315
uniprot id: E8QXB8
names: Similarity
messages: Belongs to the threonine synthase family.

575540:ISOP RS07075
gene id: 575540:ISOP_RS07075
uniprot id: E8QWM3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

575540:ISOP RS13260
gene id: 575540:ISOP_RS13260
uniprot id: E8QXJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS11975
gene id: 575540:ISOP_RS11975
uniprot id: E8R547
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14540
gene id: 575540:ISOP_RS14540
uniprot id: E8R0G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

575540:ISOP RS03125
gene id: 575540:ISOP_RS03125
uniprot id: E8R060
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

575540:ISOP RS06585
gene id: 575540:ISOP_RS06585
uniprot id: E8R6C3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

575540:ISOP RS19290
gene id: 575540:ISOP_RS19290
uniprot id: E8QYH8
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

575540:ISOP RS04230
gene id: 575540:ISOP_RS04230
uniprot id: E8R1W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell inner membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

575540:ISOP RS03350
gene id: 575540:ISOP_RS03350
uniprot id: E8R0N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

575540:ISOP RS09315
gene id: 575540:ISOP_RS09315
uniprot id: E8R0X1
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14270
gene id: 575540:ISOP_RS14270
uniprot id: E8QZV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

575540:ISOP RS08685
gene id: 575540:ISOP_RS08685
uniprot id: E8R081
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

575540:ISOP RS14715
gene id: 575540:ISOP_RS14715
uniprot id: E8R0J2
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

575540:ISOP RS11020
gene id: 575540:ISOP_RS11020
uniprot id: E8R3P5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

575540:ISOP RS00255
gene id: 575540:ISOP_RS00255
uniprot id: E8R4Q6
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS19035
gene id: 575540:ISOP_RS19035
uniprot id: E8QXT1
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

575540:ISOP RS16615
gene id: 575540:ISOP_RS16615
uniprot id: E8R3U9
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily.

575540:ISOP RS08515
gene id: 575540:ISOP_RS08515
uniprot id: E8QZP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

575540:ISOP RS06795
gene id: 575540:ISOP_RS06795
uniprot id: E8R6G2
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS13415
gene id: 575540:ISOP_RS13415
uniprot id: E8QXM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

575540:ISOP RS18210
gene id: 575540:ISOP_RS18210
uniprot id: E8R6R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

575540:ISOP RS02830
gene id: 575540:ISOP_RS02830
uniprot id: E8QZJ3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

575540:ISOP RS15450
gene id: 575540:ISOP_RS15450
uniprot id: E8R1P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

575540:ISOP RS03330
gene id: 575540:ISOP_RS03330
uniprot id: E8R0N3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS20400
gene id: 575540:ISOP_RS20400
uniprot id: E8R0Q0
names: Similarity
messages: Belongs to the peptidase A24 family.

575540:ISOP RS13400
gene id: 575540:ISOP_RS13400
uniprot id: E8QXM5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

575540:ISOP RS18220
gene id: 575540:ISOP_RS18220
uniprot id: E8R6R9
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS00505
gene id: 575540:ISOP_RS00505
uniprot id: E8R5F1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

575540:ISOP RS03325
gene id: 575540:ISOP_RS03325
uniprot id: E8R0N1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS09620
gene id: 575540:ISOP_RS09620
uniprot id: E8R1F4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

575540:ISOP RS06895
gene id: 575540:ISOP_RS06895
uniprot id: E8QWI8
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

575540:ISOP RS11455
gene id: 575540:ISOP_RS11455
uniprot id: E8R4A9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

575540:ISOP RS10485
gene id: 575540:ISOP_RS10485
uniprot id: E8R2N0
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS16520
gene id: 575540:ISOP_RS16520
uniprot id: E8R3E8
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS18580
gene id: 575540:ISOP_RS18580
uniprot id: E8QWZ5
names: Similarity
messages: Belongs to the UPF0234 family.

575540:ISOP RS02545
gene id: 575540:ISOP_RS02545
uniprot id: E8QZE6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

575540:ISOP RS13560
gene id: 575540:ISOP_RS13560
uniprot id: E8QYB0
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

575540:ISOP RS11255
gene id: 575540:ISOP_RS11255
uniprot id: E8R3T7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

575540:ISOP RS08785
gene id: 575540:ISOP_RS08785
uniprot id: E8R098
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

575540:ISOP RS15070
gene id: 575540:ISOP_RS15070
uniprot id: E8R136
names: Similarity
messages: Belongs to the GSP E family.

575540:ISOP RS16815
gene id: 575540:ISOP_RS16815
uniprot id: E8R3Y9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

575540:ISOP RS21195
gene id: 575540:ISOP_RS21195
uniprot id: E8R0G2
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS19275
gene id: 575540:ISOP_RS19275
uniprot id: E8QYH5
names: Similarity
messages: Belongs to the threonine aldolase family.

575540:ISOP RS08340
gene id: 575540:ISOP_RS08340
uniprot id: E8QZL0
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS11190
gene id: 575540:ISOP_RS11190
uniprot id: E8R3S4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

575540:ISOP RS20330
gene id: 575540:ISOP_RS20330
uniprot id: E8QXW2
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS05835
gene id: 575540:ISOP_RS05835
uniprot id: E8R4T8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

575540:ISOP RS11285
gene id: 575540:ISOP_RS11285
uniprot id: E8R477
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

575540:ISOP RS02750
gene id: 575540:ISOP_RS02750
uniprot id: E8QZH9
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

575540:ISOP RS03785
gene id: 575540:ISOP_RS03785
uniprot id: E8R196
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

575540:ISOP RS04635
gene id: 575540:ISOP_RS04635
uniprot id: E8R2V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS03670
gene id: 575540:ISOP_RS03670
uniprot id: E8R177
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

575540:ISOP RS00935
gene id: 575540:ISOP_RS00935
uniprot id: E8R670
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

575540:ISOP RS07545
gene id: 575540:ISOP_RS07545
uniprot id: E8QY12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS11195
gene id: 575540:ISOP_RS11195
uniprot id: E8R3S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

575540:ISOP RS15880
gene id: 575540:ISOP_RS15880
uniprot id: E8R2P6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

575540:ISOP RS08405
gene id: 575540:ISOP_RS08405
uniprot id: E8QZM3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

575540:ISOP RS04445
gene id: 575540:ISOP_RS04445
uniprot id: E8R2E3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

575540:ISOP RS17770
gene id: 575540:ISOP_RS17770
uniprot id: E8R5Z1
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS07525
gene id: 575540:ISOP_RS07525
uniprot id: E8QXF7
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

575540:ISOP RS02140
gene id: 575540:ISOP_RS02140
uniprot id: E8QYM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

575540:ISOP RS09405
gene id: 575540:ISOP_RS09405
uniprot id: E8R0Y7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

575540:ISOP RS20935
gene id: 575540:ISOP_RS20935
uniprot id: E8R2K2
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

575540:ISOP RS15625
gene id: 575540:ISOP_RS15625
uniprot id: E8R261
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

575540:ISOP RS11035
gene id: 575540:ISOP_RS11035
uniprot id: E8R3P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

575540:ISOP RS05035
gene id: 575540:ISOP_RS05035
uniprot id: E8R3H0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

575540:ISOP RS16740
gene id: 575540:ISOP_RS16740
uniprot id: E8R3X3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

575540:ISOP RS11520
gene id: 575540:ISOP_RS11520
uniprot id: E8R4C0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

575540:ISOP RS12895
gene id: 575540:ISOP_RS12895
uniprot id: E8QWS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell inner membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

575540:ISOP RS18205
gene id: 575540:ISOP_RS18205
uniprot id: E8R6R6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

575540:ISOP RS13315
gene id: 575540:ISOP_RS13315
uniprot id: E8QXL0
names: Similarity
messages: Belongs to the threonine synthase family.

575540:ISOP RS18250
gene id: 575540:ISOP_RS18250
uniprot id: E8R6S3
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

575540:ISOP RS14760
gene id: 575540:ISOP_RS14760
uniprot id: E8R0K1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS18870
gene id: 575540:ISOP_RS18870
uniprot id: E8QXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

575540:ISOP RS02030
gene id: 575540:ISOP_RS02030
uniprot id: E8QXZ8
names: Similarity
messages: Belongs to the UDPGP type 1 family.

575540:ISOP RS02020
gene id: 575540:ISOP_RS02020
uniprot id: E8QXZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

575540:ISOP RS15365
gene id: 575540:ISOP_RS15365
uniprot id: E8R1M5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

575540:ISOP RS21300
gene id: 575540:ISOP_RS21300
uniprot id: E8R397
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

575540:ISOP RS08375
gene id: 575540:ISOP_RS08375
uniprot id: E8QZL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

575540:ISOP RS05675
gene id: 575540:ISOP_RS05675
uniprot id: E8R470
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

575540:ISOP RS17005
gene id: 575540:ISOP_RS17005
uniprot id: E8R4G0
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS05280
gene id: 575540:ISOP_RS05280
uniprot id: E8R3L8
names: Similarity
messages: Belongs to the asparagine synthetase family.

575540:ISOP RS08510
gene id: 575540:ISOP_RS08510
uniprot id: E8QZP4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS08500
gene id: 575540:ISOP_RS08500
uniprot id: E8QZP2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

575540:ISOP RS12815
gene id: 575540:ISOP_RS12815
uniprot id: E8QWR5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

575540:ISOP RS14970
gene id: 575540:ISOP_RS14970
uniprot id: E8R119
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

575540:ISOP RS14210
gene id: 575540:ISOP_RS14210
uniprot id: E8QZT8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

575540:ISOP RS01960
gene id: 575540:ISOP_RS01960
uniprot id: E8QXY4
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS09795
gene id: 575540:ISOP_RS09795
uniprot id: E8R1I4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS20300
gene id: 575540:ISOP_RS20300
uniprot id: E8QWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

575540:ISOP RS17575
gene id: 575540:ISOP_RS17575
uniprot id: E8R5A4
names: Similarity
messages: Belongs to the DNA photolyase family.

575540:ISOP RS08695
gene id: 575540:ISOP_RS08695
uniprot id: E8R083
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

575540:ISOP RS04455
gene id: 575540:ISOP_RS04455
uniprot id: E8R2E5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

575540:ISOP RS04505
gene id: 575540:ISOP_RS04505
uniprot id: E8R2F3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS11665
gene id: 575540:ISOP_RS11665
uniprot id: E8R4Z0
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

575540:ISOP RS07965
gene id: 575540:ISOP_RS07965
uniprot id: E8QYU1
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

575540:ISOP RS07360
gene id: 575540:ISOP_RS07360
uniprot id: E8QXC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

575540:ISOP RS14240
gene id: 575540:ISOP_RS14240
uniprot id: E8QZU4
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS00240
gene id: 575540:ISOP_RS00240
uniprot id: E8R4Q3
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS14115
gene id: 575540:ISOP_RS14115
uniprot id: E8QZS0
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

575540:ISOP RS09060
gene id: 575540:ISOP_RS09060
uniprot id: E8R0S6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

575540:ISOP RS06980
gene id: 575540:ISOP_RS06980
uniprot id: E8QWK6
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

575540:ISOP RS16515
gene id: 575540:ISOP_RS16515
uniprot id: E8R3E7
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS21400
gene id: 575540:ISOP_RS21400
uniprot id: E8R5Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

575540:ISOP RS11245
gene id: 575540:ISOP_RS11245
uniprot id: E8R3T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

575540:ISOP RS02820
gene id: 575540:ISOP_RS02820
uniprot id: E8QZJ1
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

575540:ISOP RS08705
gene id: 575540:ISOP_RS08705
uniprot id: E8R085
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

575540:ISOP RS20110
gene id: 575540:ISOP_RS20110
uniprot id: E8R6W3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

575540:ISOP RS20900
gene id: 575540:ISOP_RS20900
uniprot id: E8R231
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kinesin light chain family.
messages: cytoskeleton

575540:ISOP RS12225
gene id: 575540:ISOP_RS12225
uniprot id: E8R5U3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

575540:ISOP RS15615
gene id: 575540:ISOP_RS15615
uniprot id: E8R259
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

575540:ISOP RS18415
gene id: 575540:ISOP_RS18415
uniprot id: E8QWW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

575540:ISOP RS10965
gene id: 575540:ISOP_RS10965
uniprot id: E8R3N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

575540:ISOP RS18660
gene id: 575540:ISOP_RS18660
uniprot id: E8QX11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

575540:ISOP RS16210
gene id: 575540:ISOP_RS16210
uniprot id: E8R2V3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

575540:ISOP RS00230
gene id: 575540:ISOP_RS00230
uniprot id: E8R4Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

575540:ISOP RS07295
gene id: 575540:ISOP_RS07295
uniprot id: E8QXB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

575540:ISOP RS00955
gene id: 575540:ISOP_RS00955
uniprot id: E8R674
names: PTM
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

575540:ISOP RS07340
gene id: 575540:ISOP_RS07340
uniprot id: E8QXC3
names: Similarity
messages: Belongs to the peptidase M1 family.

575540:ISOP RS00600
gene id: 575540:ISOP_RS00600
uniprot id: E8R5G8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

575540:ISOP RS11200
gene id: 575540:ISOP_RS11200
uniprot id: E8R3S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

575540:ISOP RS06505
gene id: 575540:ISOP_RS06505
uniprot id: E8R6A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Membrane

575540:ISOP RS18850
gene id: 575540:ISOP_RS18850
uniprot id: E8QXP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

575540:ISOP RS01710
gene id: 575540:ISOP_RS01710
uniprot id: E8QX79
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

575540:ISOP RS04200
gene id: 575540:ISOP_RS04200
uniprot id: E8R1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

575540:ISOP RS00155
gene id: 575540:ISOP_RS00155
uniprot id: E8R4N6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

575540:ISOP RS07520
gene id: 575540:ISOP_RS07520
uniprot id: E8QXF6
names: Subcellular Location Annotation
messages: Membrane

575540:ISOP RS17495
gene id: 575540:ISOP_RS17495
uniprot id: E8R591
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm

575540:ISOP RS19500
gene id: 575540:ISOP_RS19500
uniprot id: E8QZ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell inner membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

575540:ISOP RS18960
gene id: 575540:ISOP_RS18960
uniprot id: E8QXR7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

575540:ISOP RS15040
gene id: 575540:ISOP_RS15040
uniprot id: E8R131
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.

575540:ISOP RS01140
gene id: 575540:ISOP_RS01140
uniprot id: E8QWB9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

575540:ISOP RS01545
gene id: 575540:ISOP_RS01545
uniprot id: E8QX51
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

575540:ISOP RS05680
gene id: 575540:ISOP_RS05680
uniprot id: E8R471
names: Similarity
messages: Belongs to the RibF family.

575540:ISOP RS07730
gene id: 575540:ISOP_RS07730
uniprot id: E8QY42
names: Similarity
messages: Belongs to the AlaDH/PNT family.