573064:MEFER RS05775
gene id: 573064:MEFER_RS05775
uniprot id: C7P8R2
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06715
gene id: 573064:MEFER_RS06715
uniprot id: C7P999
names: Similarity
messages: Belongs to the UPF0179 family.

573064:MEFER RS03150
gene id: 573064:MEFER_RS03150
uniprot id: C7P7B6
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS01825
gene id: 573064:MEFER_RS01825
uniprot id: C7P6L8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

573064:MEFER RS04260
gene id: 573064:MEFER_RS04260
uniprot id: C7P7Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

573064:MEFER RS04060
gene id: 573064:MEFER_RS04060
uniprot id: C7P7U4
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

573064:MEFER RS07535
gene id: 573064:MEFER_RS07535
uniprot id: C7P5B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

573064:MEFER RS06470
gene id: 573064:MEFER_RS06470
uniprot id: C7P950
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

573064:MEFER RS00180
gene id: 573064:MEFER_RS00180
uniprot id: C7P5P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

573064:MEFER RS06275
gene id: 573064:MEFER_RS06275
uniprot id: C7P911
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS03490
gene id: 573064:MEFER_RS03490
uniprot id: C7P7I0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

573064:MEFER RS06095
gene id: 573064:MEFER_RS06095
uniprot id: C7P8X4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

573064:MEFER RS07285
gene id: 573064:MEFER_RS07285
uniprot id: C7P9L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

573064:MEFER RS01560
gene id: 573064:MEFER_RS01560
uniprot id: C7P6G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

573064:MEFER RS06565
gene id: 573064:MEFER_RS06565
uniprot id: C7P969
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

573064:MEFER RS00535
gene id: 573064:MEFER_RS00535
uniprot id: C7P5W9
names: Similarity
messages: Belongs to the UPF0045 family.

573064:MEFER RS04415
gene id: 573064:MEFER_RS04415
uniprot id: C7P806
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

573064:MEFER RS07155
gene id: 573064:MEFER_RS07155
uniprot id: C7P9I5
names: Similarity
messages: Belongs to the peptidase C56 family.

573064:MEFER RS01795
gene id: 573064:MEFER_RS01795
uniprot id: C7P6L2
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06660
gene id: 573064:MEFER_RS06660
uniprot id: C7P988
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

573064:MEFER RS02380
gene id: 573064:MEFER_RS02380
uniprot id: C7P6W7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS00035
gene id: 573064:MEFER_RS00035
uniprot id: C7P5L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

573064:MEFER RS03700
gene id: 573064:MEFER_RS03700
uniprot id: C7P7M1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

573064:MEFER RS00545
gene id: 573064:MEFER_RS00545
uniprot id: C7P5X1
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

573064:MEFER RS04775
gene id: 573064:MEFER_RS04775
uniprot id: C7P874
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

573064:MEFER RS00205
gene id: 573064:MEFER_RS00205
uniprot id: C7P5Q2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS06360
gene id: 573064:MEFER_RS06360
uniprot id: C7P928
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

573064:MEFER RS02135
gene id: 573064:MEFER_RS02135
uniprot id: C7P6R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

573064:MEFER RS03470
gene id: 573064:MEFER_RS03470
uniprot id: C7P7H6
names: Similarity
messages: Belongs to the SUI1 family.

573064:MEFER RS00900
gene id: 573064:MEFER_RS00900
uniprot id: C7P640
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

573064:MEFER RS00235
gene id: 573064:MEFER_RS00235
uniprot id: C7P5Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

573064:MEFER RS03930
gene id: 573064:MEFER_RS03930
uniprot id: C7P7R7
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

573064:MEFER RS07690
gene id: 573064:MEFER_RS07690
uniprot id: C7P5E7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

573064:MEFER RS03090
gene id: 573064:MEFER_RS03090
uniprot id: C7P7A4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

573064:MEFER RS07525
gene id: 573064:MEFER_RS07525
uniprot id: C7P5B3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS07345
gene id: 573064:MEFER_RS07345
uniprot id: C7P9M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

573064:MEFER RS04305
gene id: 573064:MEFER_RS04305
uniprot id: C7P7Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

573064:MEFER RS01975
gene id: 573064:MEFER_RS01975
uniprot id: C7P6P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573064:MEFER RS04980
gene id: 573064:MEFER_RS04980
uniprot id: C7P8B7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS01400
gene id: 573064:MEFER_RS01400
uniprot id: C7P6D8
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

573064:MEFER RS06815
gene id: 573064:MEFER_RS06815
uniprot id: C7P9C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

573064:MEFER RS06080
gene id: 573064:MEFER_RS06080
uniprot id: C7P8X1
names: Similarity
names: Subunit
messages: Belongs to the L-cysteine desulfidase family.
messages: Homotrimer.

573064:MEFER RS04610
gene id: 573064:MEFER_RS04610
uniprot id: C7P843
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

573064:MEFER RS02685
gene id: 573064:MEFER_RS02685
uniprot id: C7P722
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

573064:MEFER RS06340
gene id: 573064:MEFER_RS06340
uniprot id: C7P924
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

573064:MEFER RS02310
gene id: 573064:MEFER_RS02310
uniprot id: C7P6V3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

573064:MEFER RS06950
gene id: 573064:MEFER_RS06950
uniprot id: C7P9E6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

573064:MEFER RS00865
gene id: 573064:MEFER_RS00865
uniprot id: C7P633
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

573064:MEFER RS06685
gene id: 573064:MEFER_RS06685
uniprot id: C7P993
names: Similarity
messages: Belongs to the UPF0288 family.

573064:MEFER RS02280
gene id: 573064:MEFER_RS02280
uniprot id: C7P6U9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

573064:MEFER RS04445
gene id: 573064:MEFER_RS04445
uniprot id: C7P810
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

573064:MEFER RS07180
gene id: 573064:MEFER_RS07180
uniprot id: C7P9J0
names: Similarity
messages: Belongs to the UPF0248 family.

573064:MEFER RS02445
gene id: 573064:MEFER_RS02445
uniprot id: C7P6X9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

573064:MEFER RS00270
gene id: 573064:MEFER_RS00270
uniprot id: C7P5R5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS03805
gene id: 573064:MEFER_RS03805
uniprot id: C7P7P2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

573064:MEFER RS03240
gene id: 573064:MEFER_RS03240
uniprot id: C7P7D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

573064:MEFER RS02800
gene id: 573064:MEFER_RS02800
uniprot id: C7P746
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

573064:MEFER RS02640
gene id: 573064:MEFER_RS02640
uniprot id: C7P714
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

573064:MEFER RS06415
gene id: 573064:MEFER_RS06415
uniprot id: C7P939
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

573064:MEFER RS03210
gene id: 573064:MEFER_RS03210
uniprot id: C7P7C6
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

573064:MEFER RS04120
gene id: 573064:MEFER_RS04120
uniprot id: C7P7V6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

573064:MEFER RS07580
gene id: 573064:MEFER_RS07580
uniprot id: C7P5C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

573064:MEFER RS01630
gene id: 573064:MEFER_RS01630
uniprot id: C7P6I2
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS03460
gene id: 573064:MEFER_RS03460
uniprot id: C7P7H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS01310
gene id: 573064:MEFER_RS01310
uniprot id: C7P6B9
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

573064:MEFER RS06045
gene id: 573064:MEFER_RS06045
uniprot id: C7P8W5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

573064:MEFER RS02500
gene id: 573064:MEFER_RS02500
uniprot id: C7P6Y7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

573064:MEFER RS05280
gene id: 573064:MEFER_RS05280
uniprot id: C7P8H9
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

573064:MEFER RS04045
gene id: 573064:MEFER_RS04045
uniprot id: C7P7U1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

573064:MEFER RS03580
gene id: 573064:MEFER_RS03580
uniprot id: C7P7J7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

573064:MEFER RS04650
gene id: 573064:MEFER_RS04650
uniprot id: C7P851
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS01320
gene id: 573064:MEFER_RS01320
uniprot id: C7P6C1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

573064:MEFER RS04465
gene id: 573064:MEFER_RS04465
uniprot id: C7P814
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

573064:MEFER RS07370
gene id: 573064:MEFER_RS07370
uniprot id: C7P9M7
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS07730
gene id: 573064:MEFER_RS07730
uniprot id: C7P5F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

573064:MEFER RS00045
gene id: 573064:MEFER_RS00045
uniprot id: C7P5L9
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS00500
gene id: 573064:MEFER_RS00500
uniprot id: C7P5W2
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

573064:MEFER RS07715
gene id: 573064:MEFER_RS07715
uniprot id: C7P5F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

573064:MEFER RS02540
gene id: 573064:MEFER_RS02540
uniprot id: C7P6Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

573064:MEFER RS00935
gene id: 573064:MEFER_RS00935
uniprot id: C7P647
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

573064:MEFER RS06240
gene id: 573064:MEFER_RS06240
uniprot id: C7P904
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

573064:MEFER RS06405
gene id: 573064:MEFER_RS06405
uniprot id: C7P937
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

573064:MEFER RS01300
gene id: 573064:MEFER_RS01300
uniprot id: C7P6B7
names: Similarity
messages: Belongs to the UPF0305 family.

573064:MEFER RS07340
gene id: 573064:MEFER_RS07340
uniprot id: C7P9M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

573064:MEFER RS03440
gene id: 573064:MEFER_RS03440
uniprot id: C7P7H0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

573064:MEFER RS06480
gene id: 573064:MEFER_RS06480
uniprot id: C7P952
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

573064:MEFER RS06450
gene id: 573064:MEFER_RS06450
uniprot id: C7P946
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS04605
gene id: 573064:MEFER_RS04605
uniprot id: C7P842
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

573064:MEFER RS05190
gene id: 573064:MEFER_RS05190
uniprot id: C7P8G2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS07660
gene id: 573064:MEFER_RS07660
uniprot id: C7P5E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

573064:MEFER RS03265
gene id: 573064:MEFER_RS03265
uniprot id: C7P7D7
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS01000
gene id: 573064:MEFER_RS01000
uniprot id: C7P657
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

573064:MEFER RS06645
gene id: 573064:MEFER_RS06645
uniprot id: C7P985
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

573064:MEFER RS02745
gene id: 573064:MEFER_RS02745
uniprot id: C7P735
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

573064:MEFER RS03790
gene id: 573064:MEFER_RS03790
uniprot id: C7P7N9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

573064:MEFER RS01870
gene id: 573064:MEFER_RS01870
uniprot id: C7P6M6
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

573064:MEFER RS03725
gene id: 573064:MEFER_RS03725
uniprot id: C7P7M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

573064:MEFER RS04660
gene id: 573064:MEFER_RS04660
uniprot id: C7P853
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS03545
gene id: 573064:MEFER_RS03545
uniprot id: C7P7J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

573064:MEFER RS04240
gene id: 573064:MEFER_RS04240
uniprot id: C7P7X8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS05020
gene id: 573064:MEFER_RS05020
uniprot id: C7P8C5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

573064:MEFER RS03600
gene id: 573064:MEFER_RS03600
uniprot id: C7P7K1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

573064:MEFER RS05520
gene id: 573064:MEFER_RS05520
uniprot id: C7P8L0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS03380
gene id: 573064:MEFER_RS03380
uniprot id: C7P7F9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

573064:MEFER RS06635
gene id: 573064:MEFER_RS06635
uniprot id: C7P983
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573064:MEFER RS07000
gene id: 573064:MEFER_RS07000
uniprot id: C7P9F6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

573064:MEFER RS05210
gene id: 573064:MEFER_RS05210
uniprot id: C7P8G6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

573064:MEFER RS01440
gene id: 573064:MEFER_RS01440
uniprot id: C7P6E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

573064:MEFER RS02955
gene id: 573064:MEFER_RS02955
uniprot id: C7P778
names: Similarity
messages: Belongs to the UPF0166 family.

573064:MEFER RS02990
gene id: 573064:MEFER_RS02990
uniprot id: C7P785
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

573064:MEFER RS07705
gene id: 573064:MEFER_RS07705
uniprot id: C7P5F0
names: Similarity
messages: Belongs to the UPF0280 family.

573064:MEFER RS05275
gene id: 573064:MEFER_RS05275
uniprot id: C7P8H8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

573064:MEFER RS00650
gene id: 573064:MEFER_RS00650
uniprot id: C7P5Z2
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS03590
gene id: 573064:MEFER_RS03590
uniprot id: C7P7J9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

573064:MEFER RS01860
gene id: 573064:MEFER_RS01860
uniprot id: C7P6M4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

573064:MEFER RS02970
gene id: 573064:MEFER_RS02970
uniprot id: C7P781
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

573064:MEFER RS05560
gene id: 573064:MEFER_RS05560
uniprot id: C7P8L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

573064:MEFER RS06260
gene id: 573064:MEFER_RS06260
uniprot id: C7P908
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

573064:MEFER RS05450
gene id: 573064:MEFER_RS05450
uniprot id: C7P8K6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

573064:MEFER RS00905
gene id: 573064:MEFER_RS00905
uniprot id: C7P641
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

573064:MEFER RS04815
gene id: 573064:MEFER_RS04815
uniprot id: C7P882
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS03475
gene id: 573064:MEFER_RS03475
uniprot id: C7P7H7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

573064:MEFER RS06575
gene id: 573064:MEFER_RS06575
uniprot id: C7P971
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

573064:MEFER RS04035
gene id: 573064:MEFER_RS04035
uniprot id: C7P7T9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

573064:MEFER RS02460
gene id: 573064:MEFER_RS02460
uniprot id: C7P6Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

573064:MEFER RS01765
gene id: 573064:MEFER_RS01765
uniprot id: C7P6K6
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS07245
gene id: 573064:MEFER_RS07245
uniprot id: C7P9K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

573064:MEFER RS07615
gene id: 573064:MEFER_RS07615
uniprot id: C7P5D2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

573064:MEFER RS02350
gene id: 573064:MEFER_RS02350
uniprot id: C7P6W1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

573064:MEFER RS05705
gene id: 573064:MEFER_RS05705
uniprot id: C7P8P8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

573064:MEFER RS01535
gene id: 573064:MEFER_RS01535
uniprot id: C7P6G3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.
messages: Belongs to the ribosomal protein L31e family.

573064:MEFER RS01575
gene id: 573064:MEFER_RS01575
uniprot id: C7P6H1
names: Similarity
messages: Belongs to the ZPR1 family.

573064:MEFER RS03665
gene id: 573064:MEFER_RS03665
uniprot id: C7P7L4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

573064:MEFER RS04930
gene id: 573064:MEFER_RS04930
uniprot id: C7P8A7
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

573064:MEFER RS00085
gene id: 573064:MEFER_RS00085
uniprot id: C7P5M8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

573064:MEFER RS06000
gene id: 573064:MEFER_RS06000
uniprot id: C7P8V6
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

573064:MEFER RS07225
gene id: 573064:MEFER_RS07225
uniprot id: C7P9J8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

573064:MEFER RS00525
gene id: 573064:MEFER_RS00525
uniprot id: C7P5W7
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

573064:MEFER RS06750
gene id: 573064:MEFER_RS06750
uniprot id: C7P9A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

573064:MEFER RS04920
gene id: 573064:MEFER_RS04920
uniprot id: C7P8A5
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

573064:MEFER RS05435
gene id: 573064:MEFER_RS05435
uniprot id: C7P8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

573064:MEFER RS03615
gene id: 573064:MEFER_RS03615
uniprot id: C7P7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573064:MEFER RS04595
gene id: 573064:MEFER_RS04595
uniprot id: C7P840
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS01530
gene id: 573064:MEFER_RS01530
uniprot id: C7P6G2
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

573064:MEFER RS03950
gene id: 573064:MEFER_RS03950
uniprot id: C7P7S1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS01470
gene id: 573064:MEFER_RS01470
uniprot id: C7P6F0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

573064:MEFER RS00860
gene id: 573064:MEFER_RS00860
uniprot id: C7P632
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

573064:MEFER RS04795
gene id: 573064:MEFER_RS04795
uniprot id: C7P878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS04830
gene id: 573064:MEFER_RS04830
uniprot id: C7P885
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

573064:MEFER RS05120
gene id: 573064:MEFER_RS05120
uniprot id: C7P8E7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

573064:MEFER RS02880
gene id: 573064:MEFER_RS02880
uniprot id: C7P762
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS01715
gene id: 573064:MEFER_RS01715
uniprot id: C7P6J8
names: Similarity
messages: Belongs to the pyruvate kinase family.

573064:MEFER RS01810
gene id: 573064:MEFER_RS01810
uniprot id: C7P6L5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

573064:MEFER RS02645
gene id: 573064:MEFER_RS02645
uniprot id: C7P715
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

573064:MEFER RS05445
gene id: 573064:MEFER_RS05445
uniprot id: C7P8K5
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

573064:MEFER RS03795
gene id: 573064:MEFER_RS03795
uniprot id: C7P7P0
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

573064:MEFER RS04065
gene id: 573064:MEFER_RS04065
uniprot id: C7P7U5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

573064:MEFER RS05815
gene id: 573064:MEFER_RS05815
uniprot id: C7P8S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573064:MEFER RS04670
gene id: 573064:MEFER_RS04670
uniprot id: C7P855
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

573064:MEFER RS06695
gene id: 573064:MEFER_RS06695
uniprot id: C7P995
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

573064:MEFER RS07080
gene id: 573064:MEFER_RS07080
uniprot id: C7P9H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

573064:MEFER RS04780
gene id: 573064:MEFER_RS04780
uniprot id: C7P875
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS07460
gene id: 573064:MEFER_RS07460
uniprot id: C7P599
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

573064:MEFER RS01865
gene id: 573064:MEFER_RS01865
uniprot id: C7P6M5
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

573064:MEFER RS05175
gene id: 573064:MEFER_RS05175
uniprot id: C7P8F9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

573064:MEFER RS03375
gene id: 573064:MEFER_RS03375
uniprot id: C7P7F8
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS02875
gene id: 573064:MEFER_RS02875
uniprot id: C7P761
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

573064:MEFER RS06335
gene id: 573064:MEFER_RS06335
uniprot id: C7P923
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

573064:MEFER RS02180
gene id: 573064:MEFER_RS02180
uniprot id: C7P6S9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

573064:MEFER RS06510
gene id: 573064:MEFER_RS06510
uniprot id: C7P958
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

573064:MEFER RS00880
gene id: 573064:MEFER_RS00880
uniprot id: C7P636
names: Similarity
messages: Belongs to the glutamate synthase family.

573064:MEFER RS06040
gene id: 573064:MEFER_RS06040
uniprot id: C7P8W4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

573064:MEFER RS00120
gene id: 573064:MEFER_RS00120
uniprot id: C7P5N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

573064:MEFER RS00730
gene id: 573064:MEFER_RS00730
uniprot id: C7P608
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

573064:MEFER RS06855
gene id: 573064:MEFER_RS06855
uniprot id: C7P9C6
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

573064:MEFER RS07050
gene id: 573064:MEFER_RS07050
uniprot id: C7P9G6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

573064:MEFER RS00390
gene id: 573064:MEFER_RS00390
uniprot id: C7P5U0
names: Similarity
messages: Belongs to the UPF0107 family.

573064:MEFER RS03550
gene id: 573064:MEFER_RS03550
uniprot id: C7P7J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

573064:MEFER RS03635
gene id: 573064:MEFER_RS03635
uniprot id: C7P7K8
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

573064:MEFER RS04310
gene id: 573064:MEFER_RS04310
uniprot id: C7P7Z2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

573064:MEFER RS07375
gene id: 573064:MEFER_RS07375
uniprot id: C7P9M8
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

573064:MEFER RS01505
gene id: 573064:MEFER_RS01505
uniprot id: C7P6F7
names: Similarity
messages: Belongs to the BtpA family.

573064:MEFER RS06305
gene id: 573064:MEFER_RS06305
uniprot id: C7P917
names: Similarity
messages: Belongs to the FrhG family.

573064:MEFER RS03900
gene id: 573064:MEFER_RS03900
uniprot id: C7P7R1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

573064:MEFER RS03860
gene id: 573064:MEFER_RS03860
uniprot id: C7P7Q3
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS01115
gene id: 573064:MEFER_RS01115
uniprot id: C7P681
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS04165
gene id: 573064:MEFER_RS04165
uniprot id: C7P7W4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

573064:MEFER RS02845
gene id: 573064:MEFER_RS02845
uniprot id: C7P755
names: Similarity
messages: Belongs to the peptidase S49 family.

573064:MEFER RS00305
gene id: 573064:MEFER_RS00305
uniprot id: C7P5S3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

573064:MEFER RS00295
gene id: 573064:MEFER_RS00295
uniprot id: C7P5S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

573064:MEFER RS00700
gene id: 573064:MEFER_RS00700
uniprot id: C7P602
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

573064:MEFER RS03160
gene id: 573064:MEFER_RS03160
uniprot id: C7P7B8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

573064:MEFER RS02780
gene id: 573064:MEFER_RS02780
uniprot id: C7P742
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS07425
gene id: 573064:MEFER_RS07425
uniprot id: C7P592
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

573064:MEFER RS02405
gene id: 573064:MEFER_RS02405
uniprot id: C7P6X2
names: Similarity
messages: Belongs to the HupF/HypC family.

573064:MEFER RS08335
gene id: 573064:MEFER_RS08335
uniprot id: C7P7G3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

573064:MEFER RS01075
gene id: 573064:MEFER_RS01075
uniprot id: C7P672
names: Similarity
messages: Belongs to the glutamate synthase family.

573064:MEFER RS05725
gene id: 573064:MEFER_RS05725
uniprot id: C7P8Q2
names: Similarity
messages: Belongs to the HdrC family.

573064:MEFER RS06975
gene id: 573064:MEFER_RS06975
uniprot id: C7P9F1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

573064:MEFER RS04095
gene id: 573064:MEFER_RS04095
uniprot id: C7P7V1
names: Similarity
messages: Belongs to the ComB family.

573064:MEFER RS02960
gene id: 573064:MEFER_RS02960
uniprot id: C7P779
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

573064:MEFER RS00635
gene id: 573064:MEFER_RS00635
uniprot id: C7P5Y9
names: Similarity
messages: Belongs to the UPF0128 family.

573064:MEFER RS00960
gene id: 573064:MEFER_RS00960
uniprot id: C7P652
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

573064:MEFER RS03455
gene id: 573064:MEFER_RS03455
uniprot id: C7P7H3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

573064:MEFER RS07205
gene id: 573064:MEFER_RS07205
uniprot id: C7P9J4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

573064:MEFER RS03480
gene id: 573064:MEFER_RS03480
uniprot id: C7P7H8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS04320
gene id: 573064:MEFER_RS04320
uniprot id: C7P7Z4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

573064:MEFER RS04790
gene id: 573064:MEFER_RS04790
uniprot id: C7P877
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS05545
gene id: 573064:MEFER_RS05545
uniprot id: C7P8L6
names: Similarity
messages: Belongs to the HisA/HisF family.

573064:MEFER RS05720
gene id: 573064:MEFER_RS05720
uniprot id: C7P8Q1
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

573064:MEFER RS04455
gene id: 573064:MEFER_RS04455
uniprot id: C7P812
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS02385
gene id: 573064:MEFER_RS02385
uniprot id: C7P6W8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

573064:MEFER RS02965
gene id: 573064:MEFER_RS02965
uniprot id: C7P780
names: Similarity
messages: Belongs to the LarC family.

573064:MEFER RS06365
gene id: 573064:MEFER_RS06365
uniprot id: C7P929
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

573064:MEFER RS06445
gene id: 573064:MEFER_RS06445
uniprot id: C7P945
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

573064:MEFER RS05715
gene id: 573064:MEFER_RS05715
uniprot id: C7P8Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS05115
gene id: 573064:MEFER_RS05115
uniprot id: C7P8E6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

573064:MEFER RS05030
gene id: 573064:MEFER_RS05030
uniprot id: C7P8C7
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

573064:MEFER RS05125
gene id: 573064:MEFER_RS05125
uniprot id: C7P8E8
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS04705
gene id: 573064:MEFER_RS04705
uniprot id: C7P862
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS01880
gene id: 573064:MEFER_RS01880
uniprot id: C7P6M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

573064:MEFER RS03435
gene id: 573064:MEFER_RS03435
uniprot id: C7P7G9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS03255
gene id: 573064:MEFER_RS03255
uniprot id: C7P7D5
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06370
gene id: 573064:MEFER_RS06370
uniprot id: C7P930
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS04220
gene id: 573064:MEFER_RS04220
uniprot id: C7P7X5
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

573064:MEFER RS04405
gene id: 573064:MEFER_RS04405
uniprot id: C7P804
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

573064:MEFER RS05880
gene id: 573064:MEFER_RS05880
uniprot id: C7P8T3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

573064:MEFER RS04625
gene id: 573064:MEFER_RS04625
uniprot id: C7P846
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

573064:MEFER RS06110
gene id: 573064:MEFER_RS06110
uniprot id: C7P8X7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

573064:MEFER RS00065
gene id: 573064:MEFER_RS00065
uniprot id: C7P5M4
names: Similarity
messages: Belongs to the MtxX family.

573064:MEFER RS05620
gene id: 573064:MEFER_RS05620
uniprot id: C7P8N1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

573064:MEFER RS01080
gene id: 573064:MEFER_RS01080
uniprot id: C7P673
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

573064:MEFER RS05025
gene id: 573064:MEFER_RS05025
uniprot id: C7P8C6
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

573064:MEFER RS02155
gene id: 573064:MEFER_RS02155
uniprot id: C7P6S4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS01280
gene id: 573064:MEFER_RS01280
uniprot id: C7P6B3
names: Similarity
messages: Belongs to the CutA family.

573064:MEFER RS01770
gene id: 573064:MEFER_RS01770
uniprot id: C7P6K7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

573064:MEFER RS03740
gene id: 573064:MEFER_RS03740
uniprot id: C7P7M9
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

573064:MEFER RS02690
gene id: 573064:MEFER_RS02690
uniprot id: C7P723
names: Similarity
messages: Belongs to the UDPGP type 2 family.

573064:MEFER RS07150
gene id: 573064:MEFER_RS07150
uniprot id: C7P9I4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

573064:MEFER RS05935
gene id: 573064:MEFER_RS05935
uniprot id: C7P8U4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

573064:MEFER RS05065
gene id: 573064:MEFER_RS05065
uniprot id: C7P8D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

573064:MEFER RS07135
gene id: 573064:MEFER_RS07135
uniprot id: C7P9I1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

573064:MEFER RS07665
gene id: 573064:MEFER_RS07665
uniprot id: C7P5E2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

573064:MEFER RS06830
gene id: 573064:MEFER_RS06830
uniprot id: C7P9C3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS02340
gene id: 573064:MEFER_RS02340
uniprot id: C7P6V9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

573064:MEFER RS03325
gene id: 573064:MEFER_RS03325
uniprot id: C7P7E8
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

573064:MEFER RS04435
gene id: 573064:MEFER_RS04435
uniprot id: C7P808
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

573064:MEFER RS00225
gene id: 573064:MEFER_RS00225
uniprot id: C7P5Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched-chain polyamine synthase family.
messages: Cytoplasm
messages: Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.

573064:MEFER RS06875
gene id: 573064:MEFER_RS06875
uniprot id: C7P9D0
names: Similarity
messages: Belongs to the aspartokinase family.

573064:MEFER RS00505
gene id: 573064:MEFER_RS00505
uniprot id: C7P5W3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

573064:MEFER RS07185
gene id: 573064:MEFER_RS07185
uniprot id: C7P9J1
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

573064:MEFER RS05555
gene id: 573064:MEFER_RS05555
uniprot id: C7P8L8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

573064:MEFER RS02330
gene id: 573064:MEFER_RS02330
uniprot id: C7P6V7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

573064:MEFER RS07020
gene id: 573064:MEFER_RS07020
uniprot id: C7P9G0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS04910
gene id: 573064:MEFER_RS04910
uniprot id: C7P8A3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

573064:MEFER RS03870
gene id: 573064:MEFER_RS03870
uniprot id: C7P7Q5
names: Similarity
messages: Belongs to the DtxR/MntR family.

573064:MEFER RS04515
gene id: 573064:MEFER_RS04515
uniprot id: C7P825
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

573064:MEFER RS01805
gene id: 573064:MEFER_RS01805
uniprot id: C7P6L4
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

573064:MEFER RS00580
gene id: 573064:MEFER_RS00580
uniprot id: C7P5X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS06540
gene id: 573064:MEFER_RS06540
uniprot id: C7P964
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

573064:MEFER RS00835
gene id: 573064:MEFER_RS00835
uniprot id: C7P627
names: Similarity
messages: Belongs to the HMD family.

573064:MEFER RS02510
gene id: 573064:MEFER_RS02510
uniprot id: C7P6Y9
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

573064:MEFER RS04030
gene id: 573064:MEFER_RS04030
uniprot id: C7P7T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

573064:MEFER RS07695
gene id: 573064:MEFER_RS07695
uniprot id: C7P5E8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

573064:MEFER RS06355
gene id: 573064:MEFER_RS06355
uniprot id: C7P927
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

573064:MEFER RS04785
gene id: 573064:MEFER_RS04785
uniprot id: C7P876
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS06385
gene id: 573064:MEFER_RS06385
uniprot id: C7P933
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

573064:MEFER RS01925
gene id: 573064:MEFER_RS01925
uniprot id: C7P6N6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

573064:MEFER RS00285
gene id: 573064:MEFER_RS00285
uniprot id: C7P5R8
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS04450
gene id: 573064:MEFER_RS04450
uniprot id: C7P811
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

573064:MEFER RS04295
gene id: 573064:MEFER_RS04295
uniprot id: C7P7Y9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

573064:MEFER RS04740
gene id: 573064:MEFER_RS04740
uniprot id: C7P867
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

573064:MEFER RS04925
gene id: 573064:MEFER_RS04925
uniprot id: C7P8A6
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

573064:MEFER RS04385
gene id: 573064:MEFER_RS04385
uniprot id: C7P800
names: Similarity
messages: Belongs to the GARS family.

573064:MEFER RS04915
gene id: 573064:MEFER_RS04915
uniprot id: C7P8A4
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

573064:MEFER RS06325
gene id: 573064:MEFER_RS06325
uniprot id: C7P921
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

573064:MEFER RS07275
gene id: 573064:MEFER_RS07275
uniprot id: C7P9K8
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

573064:MEFER RS04235
gene id: 573064:MEFER_RS04235
uniprot id: C7P7X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

573064:MEFER RS07590
gene id: 573064:MEFER_RS07590
uniprot id: C7P5C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

573064:MEFER RS03905
gene id: 573064:MEFER_RS03905
uniprot id: C7P7R2
names: Similarity
messages: Belongs to the HsdR family.

573064:MEFER RS04100
gene id: 573064:MEFER_RS04100
uniprot id: C7P7V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573064:MEFER RS05795
gene id: 573064:MEFER_RS05795
uniprot id: C7P8R6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-97 inactivates the nitrogenase reductase and regulates nitrogenase activity.

573064:MEFER RS06245
gene id: 573064:MEFER_RS06245
uniprot id: C7P905
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

573064:MEFER RS06350
gene id: 573064:MEFER_RS06350
uniprot id: C7P926
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

573064:MEFER RS03425
gene id: 573064:MEFER_RS03425
uniprot id: C7P7G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

573064:MEFER RS03680
gene id: 573064:MEFER_RS03680
uniprot id: C7P7L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

573064:MEFER RS05810
gene id: 573064:MEFER_RS05810
uniprot id: C7P8R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

573064:MEFER RS03345
gene id: 573064:MEFER_RS03345
uniprot id: C7P7F2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS07065
gene id: 573064:MEFER_RS07065
uniprot id: C7P9G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

573064:MEFER RS03920
gene id: 573064:MEFER_RS03920
uniprot id: C7P7R5
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

573064:MEFER RS05015
gene id: 573064:MEFER_RS05015
uniprot id: C7P8C4
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

573064:MEFER RS07140
gene id: 573064:MEFER_RS07140
uniprot id: C7P9I2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

573064:MEFER RS05420
gene id: 573064:MEFER_RS05420
uniprot id: C7P8K0
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

573064:MEFER RS00150
gene id: 573064:MEFER_RS00150
uniprot id: C7P5P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

573064:MEFER RS04325
gene id: 573064:MEFER_RS04325
uniprot id: C7P7Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

573064:MEFER RS04935
gene id: 573064:MEFER_RS04935
uniprot id: C7P8A8
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS00075
gene id: 573064:MEFER_RS00075
uniprot id: C7P5M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

573064:MEFER RS04195
gene id: 573064:MEFER_RS04195
uniprot id: C7P7X0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

573064:MEFER RS04870
gene id: 573064:MEFER_RS04870
uniprot id: C7P893
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

573064:MEFER RS08190
gene id: 573064:MEFER_RS08190
uniprot id: C7P732
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

573064:MEFER RS04765
gene id: 573064:MEFER_RS04765
uniprot id: C7P872
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

573064:MEFER RS03075
gene id: 573064:MEFER_RS03075
uniprot id: C7P7A1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

573064:MEFER RS06460
gene id: 573064:MEFER_RS06460
uniprot id: C7P948
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

573064:MEFER RS02660
gene id: 573064:MEFER_RS02660
uniprot id: C7P718
names: Similarity
messages: Belongs to the archaeal ATPase family.

573064:MEFER RS04770
gene id: 573064:MEFER_RS04770
uniprot id: C7P873
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

573064:MEFER RS04150
gene id: 573064:MEFER_RS04150
uniprot id: C7P7W1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

573064:MEFER RS07100
gene id: 573064:MEFER_RS07100
uniprot id: C7P9H6
names: Similarity
messages: Belongs to the DEAD box helicase family.

573064:MEFER RS00675
gene id: 573064:MEFER_RS00675
uniprot id: C7P5Z7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

573064:MEFER RS03080
gene id: 573064:MEFER_RS03080
uniprot id: C7P7A2
names: Similarity
messages: Belongs to the UPF0146 family.

573064:MEFER RS01275
gene id: 573064:MEFER_RS01275
uniprot id: C7P6B2
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

573064:MEFER RS02085
gene id: 573064:MEFER_RS02085
uniprot id: C7P6Q9
names: Similarity
messages: Belongs to the UPF0212 family.

573064:MEFER RS03330
gene id: 573064:MEFER_RS03330
uniprot id: C7P7E9
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

573064:MEFER RS03025
gene id: 573064:MEFER_RS03025
uniprot id: C7P792
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

573064:MEFER RS06765
gene id: 573064:MEFER_RS06765
uniprot id: C7P9A9
names: Similarity
messages: Belongs to the glutaredoxin family.

573064:MEFER RS00680
gene id: 573064:MEFER_RS00680
uniprot id: C7P5Z8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

573064:MEFER RS06590
gene id: 573064:MEFER_RS06590
uniprot id: C7P974
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

573064:MEFER RS02810
gene id: 573064:MEFER_RS02810
uniprot id: C7P748
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

573064:MEFER RS03355
gene id: 573064:MEFER_RS03355
uniprot id: C7P7F4
names: Similarity
messages: Belongs to the thymidylate kinase family.

573064:MEFER RS02760
gene id: 573064:MEFER_RS02760
uniprot id: C7P738
names: Similarity
messages: Belongs to the HerA family.

573064:MEFER RS01030
gene id: 573064:MEFER_RS01030
uniprot id: C7P663
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

573064:MEFER RS02325
gene id: 573064:MEFER_RS02325
uniprot id: C7P6V6
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

573064:MEFER RS06490
gene id: 573064:MEFER_RS06490
uniprot id: C7P954
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

573064:MEFER RS05525
gene id: 573064:MEFER_RS05525
uniprot id: C7P8L1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

573064:MEFER RS03970
gene id: 573064:MEFER_RS03970
uniprot id: C7P7S5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

573064:MEFER RS05550
gene id: 573064:MEFER_RS05550
uniprot id: C7P8L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

573064:MEFER RS06025
gene id: 573064:MEFER_RS06025
uniprot id: C7P8W1
names: Similarity
messages: Belongs to the MEMO1 family.

573064:MEFER RS00160
gene id: 573064:MEFER_RS00160
uniprot id: C7P5P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

573064:MEFER RS00755
gene id: 573064:MEFER_RS00755
uniprot id: C7P613
names: Similarity
messages: Belongs to the FwdC/FmdC family.

573064:MEFER RS02980
gene id: 573064:MEFER_RS02980
uniprot id: C7P783
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

573064:MEFER RS01315
gene id: 573064:MEFER_RS01315
uniprot id: C7P6C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

573064:MEFER RS07485
gene id: 573064:MEFER_RS07485
uniprot id: C7P5A4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS03735
gene id: 573064:MEFER_RS03735
uniprot id: C7P7M8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

573064:MEFER RS06820
gene id: 573064:MEFER_RS06820
uniprot id: C7P9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

573064:MEFER RS02565
gene id: 573064:MEFER_RS02565
uniprot id: C7P6Z9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

573064:MEFER RS05160
gene id: 573064:MEFER_RS05160
uniprot id: C7P8F6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS04110
gene id: 573064:MEFER_RS04110
uniprot id: C7P7V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

573064:MEFER RS07315
gene id: 573064:MEFER_RS07315
uniprot id: C7P9L6
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.

573064:MEFER RS05010
gene id: 573064:MEFER_RS05010
uniprot id: C7P8C3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

573064:MEFER RS03555
gene id: 573064:MEFER_RS03555
uniprot id: C7P7J2
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

573064:MEFER RS06390
gene id: 573064:MEFER_RS06390
uniprot id: C7P934
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

573064:MEFER RS03750
gene id: 573064:MEFER_RS03750
uniprot id: C7P7N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

573064:MEFER RS06465
gene id: 573064:MEFER_RS06465
uniprot id: C7P949
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS00565
gene id: 573064:MEFER_RS00565
uniprot id: C7P5X5
names: Subunit
messages: Homotetramer.

573064:MEFER RS03850
gene id: 573064:MEFER_RS03850
uniprot id: C7P7Q1
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

573064:MEFER RS00215
gene id: 573064:MEFER_RS00215
uniprot id: C7P5Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

573064:MEFER RS02815
gene id: 573064:MEFER_RS02815
uniprot id: C7P749
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

573064:MEFER RS07075
gene id: 573064:MEFER_RS07075
uniprot id: C7P9H1
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

573064:MEFER RS03165
gene id: 573064:MEFER_RS03165
uniprot id: C7P7B9
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

573064:MEFER RS07735
gene id: 573064:MEFER_RS07735
uniprot id: C7P5F6
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

573064:MEFER RS02360
gene id: 573064:MEFER_RS02360
uniprot id: C7P6W3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

573064:MEFER RS00750
gene id: 573064:MEFER_RS00750
uniprot id: C7P612
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

573064:MEFER RS00010
gene id: 573064:MEFER_RS00010
uniprot id: C7P5L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

573064:MEFER RS05710
gene id: 573064:MEFER_RS05710
uniprot id: C7P8P9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

573064:MEFER RS06195
gene id: 573064:MEFER_RS06195
uniprot id: C7P8Z5
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

573064:MEFER RS06940
gene id: 573064:MEFER_RS06940
uniprot id: C7P9E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS04640
gene id: 573064:MEFER_RS04640
uniprot id: C7P849
names: Similarity
messages: Belongs to the archaeal ATPase family.

573064:MEFER RS04475
gene id: 573064:MEFER_RS04475
uniprot id: C7P816
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

573064:MEFER RS00200
gene id: 573064:MEFER_RS00200
uniprot id: C7P5Q1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS06670
gene id: 573064:MEFER_RS06670
uniprot id: C7P990
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

573064:MEFER RS02240
gene id: 573064:MEFER_RS02240
uniprot id: C7P6U1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

573064:MEFER RS06980
gene id: 573064:MEFER_RS06980
uniprot id: C7P9F2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

573064:MEFER RS07545
gene id: 573064:MEFER_RS07545
uniprot id: C7P5B7
names: Similarity
messages: Belongs to the peptidase U62 family.

573064:MEFER RS05640
gene id: 573064:MEFER_RS05640
uniprot id: C7P8N5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

573064:MEFER RS03745
gene id: 573064:MEFER_RS03745
uniprot id: C7P7N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

573064:MEFER RS00245
gene id: 573064:MEFER_RS00245
uniprot id: C7P5R0
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

573064:MEFER RS03130
gene id: 573064:MEFER_RS03130
uniprot id: C7P7B2
names: Similarity
messages: Belongs to the HypE family.

573064:MEFER RS03885
gene id: 573064:MEFER_RS03885
uniprot id: C7P7Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

573064:MEFER RS06705
gene id: 573064:MEFER_RS06705
uniprot id: C7P997
names: Similarity
messages: Belongs to the UPF0282 family.

573064:MEFER RS00555
gene id: 573064:MEFER_RS00555
uniprot id: C7P5X3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

573064:MEFER RS05975
gene id: 573064:MEFER_RS05975
uniprot id: C7P8V1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

573064:MEFER RS00560
gene id: 573064:MEFER_RS00560
uniprot id: C7P5X4
names: Similarity
messages: Belongs to the UPF0147 family.

573064:MEFER RS05575
gene id: 573064:MEFER_RS05575
uniprot id: C7P8M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

573064:MEFER RS03420
gene id: 573064:MEFER_RS03420
uniprot id: C7P7G6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

573064:MEFER RS00915
gene id: 573064:MEFER_RS00915
uniprot id: C7P643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

573064:MEFER RS01015
gene id: 573064:MEFER_RS01015
uniprot id: C7P660
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

573064:MEFER RS06430
gene id: 573064:MEFER_RS06430
uniprot id: C7P942
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

573064:MEFER RS00435
gene id: 573064:MEFER_RS00435
uniprot id: C7P5U9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS05235
gene id: 573064:MEFER_RS05235
uniprot id: C7P8H1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

573064:MEFER RS02520
gene id: 573064:MEFER_RS02520
uniprot id: C7P6Z1
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS02230
gene id: 573064:MEFER_RS02230
uniprot id: C7P6T9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS02915
gene id: 573064:MEFER_RS02915
uniprot id: C7P769
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

573064:MEFER RS02550
gene id: 573064:MEFER_RS02550
uniprot id: C7P6Z7
names: Similarity
messages: Belongs to the archaeal ATPase family.

573064:MEFER RS03965
gene id: 573064:MEFER_RS03965
uniprot id: C7P7S4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

573064:MEFER RS01705
gene id: 573064:MEFER_RS01705
uniprot id: C7P6J6
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS02315
gene id: 573064:MEFER_RS02315
uniprot id: C7P6V4
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

573064:MEFER RS04440
gene id: 573064:MEFER_RS04440
uniprot id: C7P809
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

573064:MEFER RS03040
gene id: 573064:MEFER_RS03040
uniprot id: C7P795
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS03415
gene id: 573064:MEFER_RS03415
uniprot id: C7P7G5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS01215
gene id: 573064:MEFER_RS01215
uniprot id: C7P6A0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

573064:MEFER RS06380
gene id: 573064:MEFER_RS06380
uniprot id: C7P932
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

573064:MEFER RS04805
gene id: 573064:MEFER_RS04805
uniprot id: C7P880
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS06180
gene id: 573064:MEFER_RS06180
uniprot id: C7P8Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

573064:MEFER RS04520
gene id: 573064:MEFER_RS04520
uniprot id: C7P826
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

573064:MEFER RS07640
gene id: 573064:MEFER_RS07640
uniprot id: C7P5D7
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

573064:MEFER RS00715
gene id: 573064:MEFER_RS00715
uniprot id: C7P605
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

573064:MEFER RS02045
gene id: 573064:MEFER_RS02045
uniprot id: C7P6Q2
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

573064:MEFER RS01150
gene id: 573064:MEFER_RS01150
uniprot id: C7P688
names: Similarity
messages: Belongs to the DMRL synthase family.

573064:MEFER RS06985
gene id: 573064:MEFER_RS06985
uniprot id: C7P9F3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS01700
gene id: 573064:MEFER_RS01700
uniprot id: C7P6J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

573064:MEFER RS03525
gene id: 573064:MEFER_RS03525
uniprot id: C7P7I6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

573064:MEFER RS07630
gene id: 573064:MEFER_RS07630
uniprot id: C7P5D5
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

573064:MEFER RS02165
gene id: 573064:MEFER_RS02165
uniprot id: C7P6S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

573064:MEFER RS03145
gene id: 573064:MEFER_RS03145
uniprot id: C7P7B5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS07290
gene id: 573064:MEFER_RS07290
uniprot id: C7P9L1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

573064:MEFER RS03065
gene id: 573064:MEFER_RS03065
uniprot id: C7P799
names: Similarity
messages: Belongs to the PDCD5 family.

573064:MEFER RS03890
gene id: 573064:MEFER_RS03890
uniprot id: C7P7Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

573064:MEFER RS01055
gene id: 573064:MEFER_RS01055
uniprot id: C7P668
names: Similarity
messages: Belongs to the class-I fumarase family.

573064:MEFER RS03450
gene id: 573064:MEFER_RS03450
uniprot id: C7P7H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS01350
gene id: 573064:MEFER_RS01350
uniprot id: C7P6C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

573064:MEFER RS04380
gene id: 573064:MEFER_RS04380
uniprot id: C7P7Z9
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

573064:MEFER RS06225
gene id: 573064:MEFER_RS06225
uniprot id: C7P901
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS01005
gene id: 573064:MEFER_RS01005
uniprot id: C7P658
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

573064:MEFER RS02650
gene id: 573064:MEFER_RS02650
uniprot id: C7P716
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS00175
gene id: 573064:MEFER_RS00175
uniprot id: C7P5P6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

573064:MEFER RS06775
gene id: 573064:MEFER_RS06775
uniprot id: C7P9B1
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06135
gene id: 573064:MEFER_RS06135
uniprot id: C7P8Y2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS07030
gene id: 573064:MEFER_RS07030
uniprot id: C7P9G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

573064:MEFER RS03705
gene id: 573064:MEFER_RS03705
uniprot id: C7P7M2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

573064:MEFER RS00925
gene id: 573064:MEFER_RS00925
uniprot id: C7P645
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

573064:MEFER RS04040
gene id: 573064:MEFER_RS04040
uniprot id: C7P7U0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

573064:MEFER RS04265
gene id: 573064:MEFER_RS04265
uniprot id: C7P7Y3
names: Similarity
messages: Belongs to the MCM family.

573064:MEFER RS03995
gene id: 573064:MEFER_RS03995
uniprot id: C7P7T1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

573064:MEFER RS01065
gene id: 573064:MEFER_RS01065
uniprot id: C7P670
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

573064:MEFER RS04895
gene id: 573064:MEFER_RS04895
uniprot id: C7P898
names: Similarity
messages: Belongs to the UPF0210 family.

573064:MEFER RS01250
gene id: 573064:MEFER_RS01250
uniprot id: C7P6A7
names: Similarity
messages: Belongs to the archaeal ATPase family.

573064:MEFER RS01895
gene id: 573064:MEFER_RS01895
uniprot id: C7P6N0
names: Similarity
messages: Belongs to the UPF0251 family.

573064:MEFER RS00110
gene id: 573064:MEFER_RS00110
uniprot id: C7P5N3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

573064:MEFER RS03310
gene id: 573064:MEFER_RS03310
uniprot id: C7P7E5
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

573064:MEFER RS00590
gene id: 573064:MEFER_RS00590
uniprot id: C7P5Y0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

573064:MEFER RS06220
gene id: 573064:MEFER_RS06220
uniprot id: C7P900
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS00540
gene id: 573064:MEFER_RS00540
uniprot id: C7P5X0
names: Similarity
messages: Belongs to the NodU/CmcH family.

573064:MEFER RS01915
gene id: 573064:MEFER_RS01915
uniprot id: C7P6N4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

573064:MEFER RS03120
gene id: 573064:MEFER_RS03120
uniprot id: C7P7B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

573064:MEFER RS01345
gene id: 573064:MEFER_RS01345
uniprot id: C7P6C6
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

573064:MEFER RS00070
gene id: 573064:MEFER_RS00070
uniprot id: C7P5M5
names: Similarity
messages: Belongs to the UPF0285 family.

573064:MEFER RS05285
gene id: 573064:MEFER_RS05285
uniprot id: C7P8I0
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

573064:MEFER RS01305
gene id: 573064:MEFER_RS01305
uniprot id: C7P6B8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS03190
gene id: 573064:MEFER_RS03190
uniprot id: C7P7C2
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

573064:MEFER RS07215
gene id: 573064:MEFER_RS07215
uniprot id: C7P9J6
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

573064:MEFER RS06495
gene id: 573064:MEFER_RS06495
uniprot id: C7P955
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

573064:MEFER RS07330
gene id: 573064:MEFER_RS07330
uniprot id: C7P9L9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

573064:MEFER RS02150
gene id: 573064:MEFER_RS02150
uniprot id: C7P6S3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

573064:MEFER RS01125
gene id: 573064:MEFER_RS01125
uniprot id: C7P683
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

573064:MEFER RS03400
gene id: 573064:MEFER_RS03400
uniprot id: C7P7G2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS03535
gene id: 573064:MEFER_RS03535
uniprot id: C7P7I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573064:MEFER RS02985
gene id: 573064:MEFER_RS02985
uniprot id: C7P784
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

573064:MEFER RS03105
gene id: 573064:MEFER_RS03105
uniprot id: C7P7A7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

573064:MEFER RS07170
gene id: 573064:MEFER_RS07170
uniprot id: C7P9I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

573064:MEFER RS04550
gene id: 573064:MEFER_RS04550
uniprot id: C7P832
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

573064:MEFER RS03385
gene id: 573064:MEFER_RS03385
uniprot id: C7P7G0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

573064:MEFER RS03960
gene id: 573064:MEFER_RS03960
uniprot id: C7P7S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

573064:MEFER RS06420
gene id: 573064:MEFER_RS06420
uniprot id: C7P940
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573064:MEFER RS04945
gene id: 573064:MEFER_RS04945
uniprot id: C7P8B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS07500
gene id: 573064:MEFER_RS07500
uniprot id: C7P5A7
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

573064:MEFER RS03715
gene id: 573064:MEFER_RS03715
uniprot id: C7P7M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

573064:MEFER RS03395
gene id: 573064:MEFER_RS03395
uniprot id: C7P7G1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS03485
gene id: 573064:MEFER_RS03485
uniprot id: C7P7H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

573064:MEFER RS08340
gene id: 573064:MEFER_RS08340
uniprot id: C7P7G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

573064:MEFER RS02270
gene id: 573064:MEFER_RS02270
uniprot id: C7P6U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

573064:MEFER RS06440
gene id: 573064:MEFER_RS06440
uniprot id: C7P944
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

573064:MEFER RS07710
gene id: 573064:MEFER_RS07710
uniprot id: C7P5F1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

573064:MEFER RS05860
gene id: 573064:MEFER_RS05860
uniprot id: C7P8S9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS00190
gene id: 573064:MEFER_RS00190
uniprot id: C7P5P9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

573064:MEFER RS04820
gene id: 573064:MEFER_RS04820
uniprot id: C7P883
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

573064:MEFER RS07190
gene id: 573064:MEFER_RS07190
uniprot id: C7P9J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

573064:MEFER RS06720
gene id: 573064:MEFER_RS06720
uniprot id: C7P9A0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

573064:MEFER RS02455
gene id: 573064:MEFER_RS02455
uniprot id: C7P6Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS04755
gene id: 573064:MEFER_RS04755
uniprot id: C7P870
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

573064:MEFER RS07680
gene id: 573064:MEFER_RS07680
uniprot id: C7P5E5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

573064:MEFER RS06410
gene id: 573064:MEFER_RS06410
uniprot id: C7P938
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573064:MEFER RS04800
gene id: 573064:MEFER_RS04800
uniprot id: C7P879
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS00395
gene id: 573064:MEFER_RS00395
uniprot id: C7P5U1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

573064:MEFER RS00165
gene id: 573064:MEFER_RS00165
uniprot id: C7P5P4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS04145
gene id: 573064:MEFER_RS04145
uniprot id: C7P7W0
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

573064:MEFER RS07670
gene id: 573064:MEFER_RS07670
uniprot id: C7P5E3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

573064:MEFER RS04825
gene id: 573064:MEFER_RS04825
uniprot id: C7P884
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

573064:MEFER RS03195
gene id: 573064:MEFER_RS03195
uniprot id: C7P7C3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

573064:MEFER RS02465
gene id: 573064:MEFER_RS02465
uniprot id: C7P6Y3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

573064:MEFER RS03755
gene id: 573064:MEFER_RS03755
uniprot id: C7P7N2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

573064:MEFER RS00130
gene id: 573064:MEFER_RS00130
uniprot id: C7P5N7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

573064:MEFER RS01820
gene id: 573064:MEFER_RS01820
uniprot id: C7P6L7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

573064:MEFER RS01830
gene id: 573064:MEFER_RS01830
uniprot id: C7P6L9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

573064:MEFER RS02480
gene id: 573064:MEFER_RS02480
uniprot id: C7P6Y5
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06995
gene id: 573064:MEFER_RS06995
uniprot id: C7P9F5
names: Function
messages: Probably involved in the biogenesis of the ribosome.

573064:MEFER RS05570
gene id: 573064:MEFER_RS05570
uniprot id: C7P8M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

573064:MEFER RS03465
gene id: 573064:MEFER_RS03465
uniprot id: C7P7H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573064:MEFER RS01155
gene id: 573064:MEFER_RS01155
uniprot id: C7P689
names: Similarity
messages: Belongs to the AOR/FOR family.

573064:MEFER RS02390
gene id: 573064:MEFER_RS02390
uniprot id: C7P6W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

573064:MEFER RS00930
gene id: 573064:MEFER_RS00930
uniprot id: C7P646
names: Similarity
messages: Belongs to the MoaB/Mog family.

573064:MEFER RS00740
gene id: 573064:MEFER_RS00740
uniprot id: C7P610
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

573064:MEFER RS04850
gene id: 573064:MEFER_RS04850
uniprot id: C7P889
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS05760
gene id: 573064:MEFER_RS05760
uniprot id: C7P8Q9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

573064:MEFER RS02670
gene id: 573064:MEFER_RS02670
uniprot id: C7P719
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

573064:MEFER RS00040
gene id: 573064:MEFER_RS00040
uniprot id: C7P5L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

573064:MEFER RS06870
gene id: 573064:MEFER_RS06870
uniprot id: C7P9C9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

573064:MEFER RS03430
gene id: 573064:MEFER_RS03430
uniprot id: C7P7G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS04020
gene id: 573064:MEFER_RS04020
uniprot id: C7P7T6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

573064:MEFER RS01105
gene id: 573064:MEFER_RS01105
uniprot id: C7P678
names: Function
names: Similarity
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

573064:MEFER RS06570
gene id: 573064:MEFER_RS06570
uniprot id: C7P970
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS05850
gene id: 573064:MEFER_RS05850
uniprot id: C7P8S7
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

573064:MEFER RS02865
gene id: 573064:MEFER_RS02865
uniprot id: C7P759
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

573064:MEFER RS02435
gene id: 573064:MEFER_RS02435
uniprot id: C7P6X7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

573064:MEFER RS00585
gene id: 573064:MEFER_RS00585
uniprot id: C7P5X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

573064:MEFER RS03445
gene id: 573064:MEFER_RS03445
uniprot id: C7P7H1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

573064:MEFER RS06700
gene id: 573064:MEFER_RS06700
uniprot id: C7P996
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

573064:MEFER RS02365
gene id: 573064:MEFER_RS02365
uniprot id: C7P6W4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS06550
gene id: 573064:MEFER_RS06550
uniprot id: C7P966
names: Similarity
messages: Belongs to the UPF0292 family.

573064:MEFER RS01930
gene id: 573064:MEFER_RS01930
uniprot id: C7P6N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

573064:MEFER RS07445
gene id: 573064:MEFER_RS07445
uniprot id: C7P596
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS00135
gene id: 573064:MEFER_RS00135
uniprot id: C7P5N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

573064:MEFER RS00705
gene id: 573064:MEFER_RS00705
uniprot id: C7P603
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

573064:MEFER RS03295
gene id: 573064:MEFER_RS03295
uniprot id: C7P7E2
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06780
gene id: 573064:MEFER_RS06780
uniprot id: C7P9B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

573064:MEFER RS05865
gene id: 573064:MEFER_RS05865
uniprot id: C7P8T0
names: Similarity
messages: Belongs to the MCM family.

573064:MEFER RS07220
gene id: 573064:MEFER_RS07220
uniprot id: C7P9J7
names: Similarity
messages: Belongs to the UPF0111 family.

573064:MEFER RS07475
gene id: 573064:MEFER_RS07475
uniprot id: C7P5A2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

573064:MEFER RS05625
gene id: 573064:MEFER_RS05625
uniprot id: C7P8N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

573064:MEFER RS00515
gene id: 573064:MEFER_RS00515
uniprot id: C7P5W5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

573064:MEFER RS03620
gene id: 573064:MEFER_RS03620
uniprot id: C7P7K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

573064:MEFER RS02720
gene id: 573064:MEFER_RS02720
uniprot id: C7P729
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS00745
gene id: 573064:MEFER_RS00745
uniprot id: C7P611
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

573064:MEFER RS03820
gene id: 573064:MEFER_RS03820
uniprot id: C7P7P5
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

573064:MEFER RS03095
gene id: 573064:MEFER_RS03095
uniprot id: C7P7A5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

573064:MEFER RS02870
gene id: 573064:MEFER_RS02870
uniprot id: C7P760
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

573064:MEFER RS00575
gene id: 573064:MEFER_RS00575
uniprot id: C7P5X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

573064:MEFER RS04655
gene id: 573064:MEFER_RS04655
uniprot id: C7P852
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

573064:MEFER RS06740
gene id: 573064:MEFER_RS06740
uniprot id: C7P9A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

573064:MEFER RS02905
gene id: 573064:MEFER_RS02905
uniprot id: C7P767
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

573064:MEFER RS04250
gene id: 573064:MEFER_RS04250
uniprot id: C7P7Y0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

573064:MEFER RS06840
gene id: 573064:MEFER_RS06840
uniprot id: C7P9C5
names: Similarity
messages: Belongs to the UPF0047 family.

573064:MEFER RS04270
gene id: 573064:MEFER_RS04270
uniprot id: C7P7Y4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

573064:MEFER RS04015
gene id: 573064:MEFER_RS04015
uniprot id: C7P7T5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

573064:MEFER RS01850
gene id: 573064:MEFER_RS01850
uniprot id: C7P6M2
names: Similarity
messages: Belongs to the UPF0254 family.

573064:MEFER RS03660
gene id: 573064:MEFER_RS03660
uniprot id: C7P7L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

573064:MEFER RS03030
gene id: 573064:MEFER_RS03030
uniprot id: C7P793
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

573064:MEFER RS07090
gene id: 573064:MEFER_RS07090
uniprot id: C7P9H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

573064:MEFER RS07325
gene id: 573064:MEFER_RS07325
uniprot id: C7P9L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

573064:MEFER RS03340
gene id: 573064:MEFER_RS03340
uniprot id: C7P7F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

573064:MEFER RS06560
gene id: 573064:MEFER_RS06560
uniprot id: C7P968
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS02210
gene id: 573064:MEFER_RS02210
uniprot id: C7P6T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

573064:MEFER RS03915
gene id: 573064:MEFER_RS03915
uniprot id: C7P7R4
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

573064:MEFER RS06725
gene id: 573064:MEFER_RS06725
uniprot id: C7P9A1
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

573064:MEFER RS02440
gene id: 573064:MEFER_RS02440
uniprot id: C7P6X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

573064:MEFER RS03045
gene id: 573064:MEFER_RS03045
uniprot id: C7P796
names: Similarity
messages: Belongs to the P(II) protein family.

573064:MEFER RS06065
gene id: 573064:MEFER_RS06065
uniprot id: C7P8W8
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06990
gene id: 573064:MEFER_RS06990
uniprot id: C7P9F4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

573064:MEFER RS05845
gene id: 573064:MEFER_RS05845
uniprot id: C7P8S6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

573064:MEFER RS01100
gene id: 573064:MEFER_RS01100
uniprot id: C7P677
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS03060
gene id: 573064:MEFER_RS03060
uniprot id: C7P798
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

573064:MEFER RS00725
gene id: 573064:MEFER_RS00725
uniprot id: C7P607
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

573064:MEFER RS04050
gene id: 573064:MEFER_RS04050
uniprot id: C7P7U2
names: Similarity
messages: Belongs to the UPF0215 family.

573064:MEFER RS07540
gene id: 573064:MEFER_RS07540
uniprot id: C7P5B6
names: Similarity
messages: Belongs to the UPF0237 family.

573064:MEFER RS07405
gene id: 573064:MEFER_RS07405
uniprot id: C7P588
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

573064:MEFER RS07755
gene id: 573064:MEFER_RS07755
uniprot id: C7P5G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

573064:MEFER RS04170
gene id: 573064:MEFER_RS04170
uniprot id: C7P7W5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

573064:MEFER RS04600
gene id: 573064:MEFER_RS04600
uniprot id: C7P841
names: Similarity
messages: Belongs to the PstS family.

573064:MEFER RS03710
gene id: 573064:MEFER_RS03710
uniprot id: C7P7M3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

573064:MEFER RS02450
gene id: 573064:MEFER_RS02450
uniprot id: C7P6Y0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

573064:MEFER RS07745
gene id: 573064:MEFER_RS07745
uniprot id: C7P5F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

573064:MEFER RS06255
gene id: 573064:MEFER_RS06255
uniprot id: C7P907
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

573064:MEFER RS01050
gene id: 573064:MEFER_RS01050
uniprot id: C7P667
names: Similarity
messages: Belongs to the UPF0235 family.

573064:MEFER RS03760
gene id: 573064:MEFER_RS03760
uniprot id: C7P7N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

573064:MEFER RS00965
gene id: 573064:MEFER_RS00965
uniprot id: C7P653
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

573064:MEFER RS04630
gene id: 573064:MEFER_RS04630
uniprot id: C7P847
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

573064:MEFER RS02765
gene id: 573064:MEFER_RS02765
uniprot id: C7P739
names: Similarity
messages: Belongs to the UPF0201 family.

573064:MEFER RS01525
gene id: 573064:MEFER_RS01525
uniprot id: C7P6G1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS05535
gene id: 573064:MEFER_RS05535
uniprot id: C7P8L3
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

573064:MEFER RS03360
gene id: 573064:MEFER_RS03360
uniprot id: C7P7F5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

573064:MEFER RS03560
gene id: 573064:MEFER_RS03560
uniprot id: C7P7J3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

573064:MEFER RS05230
gene id: 573064:MEFER_RS05230
uniprot id: C7P8H0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

573064:MEFER RS03010
gene id: 573064:MEFER_RS03010
uniprot id: C7P789
names: Similarity
messages: Belongs to the UPF0200 family.

573064:MEFER RS02545
gene id: 573064:MEFER_RS02545
uniprot id: C7P6Z6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS04665
gene id: 573064:MEFER_RS04665
uniprot id: C7P854
names: Similarity
messages: Belongs to the band 7/mec-2 family.

573064:MEFER RS03275
gene id: 573064:MEFER_RS03275
uniprot id: C7P7D9
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

573064:MEFER RS05615
gene id: 573064:MEFER_RS05615
uniprot id: C7P8N0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

573064:MEFER RS04500
gene id: 573064:MEFER_RS04500
uniprot id: C7P821
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

573064:MEFER RS07040
gene id: 573064:MEFER_RS07040
uniprot id: C7P9G4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

573064:MEFER RS06400
gene id: 573064:MEFER_RS06400
uniprot id: C7P936
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

573064:MEFER RS00195
gene id: 573064:MEFER_RS00195
uniprot id: C7P5Q0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

573064:MEFER RS04995
gene id: 573064:MEFER_RS04995
uniprot id: C7P8C0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS04810
gene id: 573064:MEFER_RS04810
uniprot id: C7P881
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

573064:MEFER RS04875
gene id: 573064:MEFER_RS04875
uniprot id: C7P894
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS06395
gene id: 573064:MEFER_RS06395
uniprot id: C7P935
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS00330
gene id: 573064:MEFER_RS00330
uniprot id: C7P5S8
names: Similarity
messages: Belongs to the TrpC family.

573064:MEFER RS04160
gene id: 573064:MEFER_RS04160
uniprot id: C7P7W3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

573064:MEFER RS02910
gene id: 573064:MEFER_RS02910
uniprot id: C7P768
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

573064:MEFER RS05335
gene id: 573064:MEFER_RS05335
uniprot id: C7P8I6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

573064:MEFER RS03575
gene id: 573064:MEFER_RS03575
uniprot id: C7P7J6
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

573064:MEFER RS04460
gene id: 573064:MEFER_RS04460
uniprot id: C7P813
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

573064:MEFER RS06345
gene id: 573064:MEFER_RS06345
uniprot id: C7P925
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

573064:MEFER RS04205
gene id: 573064:MEFER_RS04205
uniprot id: C7P7X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

573064:MEFER RS06455
gene id: 573064:MEFER_RS06455
uniprot id: C7P947
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

573064:MEFER RS03785
gene id: 573064:MEFER_RS03785
uniprot id: C7P7N8
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

573064:MEFER RS06735
gene id: 573064:MEFER_RS06735
uniprot id: C7P9A3
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

573064:MEFER RS00300
gene id: 573064:MEFER_RS00300
uniprot id: C7P5S1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS06330
gene id: 573064:MEFER_RS06330
uniprot id: C7P922
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

573064:MEFER RS07295
gene id: 573064:MEFER_RS07295
uniprot id: C7P9L2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

573064:MEFER RS01160
gene id: 573064:MEFER_RS01160
uniprot id: C7P690
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

573064:MEFER RS07305
gene id: 573064:MEFER_RS07305
uniprot id: C7P9L4
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

573064:MEFER RS04530
gene id: 573064:MEFER_RS04530
uniprot id: C7P828
names: Similarity
messages: Belongs to the AAA ATPase family.

573064:MEFER RS02730
gene id: 573064:MEFER_RS02730
uniprot id: C7P731
names: Subcellular Location Annotation
messages: Membrane

573064:MEFER RS06005
gene id: 573064:MEFER_RS06005
uniprot id: C7P8V7
names: Cofactor
names: Function
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro.

573064:MEFER RS02950
gene id: 573064:MEFER_RS02950
uniprot id: C7P777
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

573064:MEFER RS03925
gene id: 573064:MEFER_RS03925
uniprot id: C7P7R6
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

573064:MEFER RS01285
gene id: 573064:MEFER_RS01285
uniprot id: C7P6B4
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

573064:MEFER RS00795
gene id: 573064:MEFER_RS00795
uniprot id: C7P621
names: Similarity
messages: Belongs to the UPF0173 family.

573064:MEFER RS06690
gene id: 573064:MEFER_RS06690
uniprot id: C7P994
names: Subunit
messages: Homotetramer.

573064:MEFER RS01740
gene id: 573064:MEFER_RS01740
uniprot id: C7P6K3
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

573064:MEFER RS00090
gene id: 573064:MEFER_RS00090
uniprot id: C7P5M9
names: Function
messages: Part of a potassium transport system.

573064:MEFER RS07110
gene id: 573064:MEFER_RS07110
uniprot id: C7P9H8
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

573064:MEFER RS00485
gene id: 573064:MEFER_RS00485
uniprot id: C7P5V9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

573064:MEFER RS01910
gene id: 573064:MEFER_RS01910
uniprot id: C7P6N3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

573064:MEFER RS07560
gene id: 573064:MEFER_RS07560
uniprot id: C7P5C0
names: Similarity
messages: Belongs to the HypD family.

573064:MEFER RS06795
gene id: 573064:MEFER_RS06795
uniprot id: C7P9B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS01355
gene id: 573064:MEFER_RS01355
uniprot id: C7P6C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

573064:MEFER RS07965
gene id: 573064:MEFER_RS07965
uniprot id: C7P5K4
names: Similarity
messages: Belongs to the MCM family.

573064:MEFER RS06500
gene id: 573064:MEFER_RS06500
uniprot id: C7P956
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

573064:MEFER RS03840
gene id: 573064:MEFER_RS03840
uniprot id: C7P7P9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

573064:MEFER RS01260
gene id: 573064:MEFER_RS01260
uniprot id: C7P6A9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

573064:MEFER RS06185
gene id: 573064:MEFER_RS06185
uniprot id: C7P8Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

573064:MEFER RS03720
gene id: 573064:MEFER_RS03720
uniprot id: C7P7M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

573064:MEFER RS00125
gene id: 573064:MEFER_RS00125
uniprot id: C7P5N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

573064:MEFER RS00610
gene id: 573064:MEFER_RS00610
uniprot id: C7P5Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

573064:MEFER RS02115
gene id: 573064:MEFER_RS02115
uniprot id: C7P6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

573064:MEFER RS02335
gene id: 573064:MEFER_RS02335
uniprot id: C7P6V8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

573064:MEFER RS06805
gene id: 573064:MEFER_RS06805
uniprot id: C7P9B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

573064:MEFER RS05895
gene id: 573064:MEFER_RS05895
uniprot id: C7P8T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

573064:MEFER RS07435
gene id: 573064:MEFER_RS07435
uniprot id: C7P594
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

573064:MEFER RS06665
gene id: 573064:MEFER_RS06665
uniprot id: C7P989
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm