572547:AMICO RS07205
gene id: 572547:AMICO_RS07205
uniprot id: D5EG48
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

572547:AMICO RS05120
gene id: 572547:AMICO_RS05120
uniprot id: D5EEZ3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

572547:AMICO RS08605
gene id: 572547:AMICO_RS08605
uniprot id: D5EGX3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07000
gene id: 572547:AMICO_RS07000
uniprot id: D5EG07
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

572547:AMICO RS07415
gene id: 572547:AMICO_RS07415
uniprot id: D5EG89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

572547:AMICO RS02695
gene id: 572547:AMICO_RS02695
uniprot id: D5EDP4
names: Similarity
messages: Belongs to the UPF0173 family.

572547:AMICO RS07250
gene id: 572547:AMICO_RS07250
uniprot id: D5EG57
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

572547:AMICO RS07340
gene id: 572547:AMICO_RS07340
uniprot id: D5EG75
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

572547:AMICO RS01050
gene id: 572547:AMICO_RS01050
uniprot id: D5ECT0
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

572547:AMICO RS05225
gene id: 572547:AMICO_RS05225
uniprot id: D5EF13
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

572547:AMICO RS08045
gene id: 572547:AMICO_RS08045
uniprot id: D5EGL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS02855
gene id: 572547:AMICO_RS02855
uniprot id: D5EDS2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

572547:AMICO RS09400
gene id: 572547:AMICO_RS09400
uniprot id: D5EHC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

572547:AMICO RS06770
gene id: 572547:AMICO_RS06770
uniprot id: D5EFW4
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS06655
gene id: 572547:AMICO_RS06655
uniprot id: D5EFU3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02735
gene id: 572547:AMICO_RS02735
uniprot id: D5EDQ2
names: Similarity
messages: Belongs to the asparaginase 1 family.

572547:AMICO RS06135
gene id: 572547:AMICO_RS06135
uniprot id: D5EFJ5
names: Similarity
messages: Belongs to the peptidase A24 family.

572547:AMICO RS00755
gene id: 572547:AMICO_RS00755
uniprot id: D5ECM2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS06915
gene id: 572547:AMICO_RS06915
uniprot id: D5EFZ0
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01175
gene id: 572547:AMICO_RS01175
uniprot id: D5ECV5
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01015
gene id: 572547:AMICO_RS01015
uniprot id: D5ECS3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01770
gene id: 572547:AMICO_RS01770
uniprot id: D5ED60
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS04325
gene id: 572547:AMICO_RS04325
uniprot id: D5EEJ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS04415
gene id: 572547:AMICO_RS04415
uniprot id: D5EEL5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

572547:AMICO RS03360
gene id: 572547:AMICO_RS03360
uniprot id: D5EE22
names: Similarity
messages: Belongs to the Skp family.

572547:AMICO RS08470
gene id: 572547:AMICO_RS08470
uniprot id: D5EGU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS04380
gene id: 572547:AMICO_RS04380
uniprot id: D5EEK8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572547:AMICO RS06725
gene id: 572547:AMICO_RS06725
uniprot id: D5EFV6
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS03135
gene id: 572547:AMICO_RS03135
uniprot id: D5EDX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

572547:AMICO RS03415
gene id: 572547:AMICO_RS03415
uniprot id: D5EE33
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

572547:AMICO RS03285
gene id: 572547:AMICO_RS03285
uniprot id: D5EE06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

572547:AMICO RS03050
gene id: 572547:AMICO_RS03050
uniprot id: D5EDV9
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

572547:AMICO RS03820
gene id: 572547:AMICO_RS03820
uniprot id: D5EEA9
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

572547:AMICO RS04095
gene id: 572547:AMICO_RS04095
uniprot id: D5EEF4
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02115
gene id: 572547:AMICO_RS02115
uniprot id: D5EDC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS08530
gene id: 572547:AMICO_RS08530
uniprot id: D5EGV8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS03440
gene id: 572547:AMICO_RS03440
uniprot id: D5EE38
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

572547:AMICO RS07760
gene id: 572547:AMICO_RS07760
uniprot id: D5EGF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

572547:AMICO RS03725
gene id: 572547:AMICO_RS03725
uniprot id: D5EE91
names: Similarity
messages: Belongs to the UDPGP type 2 family.

572547:AMICO RS09365
gene id: 572547:AMICO_RS09365
uniprot id: D5EHC1
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

572547:AMICO RS05270
gene id: 572547:AMICO_RS05270
uniprot id: D5EF22
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06500
gene id: 572547:AMICO_RS06500
uniprot id: D5EFR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS07475
gene id: 572547:AMICO_RS07475
uniprot id: D5EGA1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS08505
gene id: 572547:AMICO_RS08505
uniprot id: D5EGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

572547:AMICO RS02255
gene id: 572547:AMICO_RS02255
uniprot id: D5EDF4
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS00465
gene id: 572547:AMICO_RS00465
uniprot id: D5ECG3
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

572547:AMICO RS09440
gene id: 572547:AMICO_RS09440
uniprot id: D5EHD7
names: Similarity
messages: Belongs to the CdaR family.

572547:AMICO RS03125
gene id: 572547:AMICO_RS03125
uniprot id: D5EDX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

572547:AMICO RS01130
gene id: 572547:AMICO_RS01130
uniprot id: D5ECU6
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

572547:AMICO RS09585
gene id: 572547:AMICO_RS09585
uniprot id: D5EHG7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS09045
gene id: 572547:AMICO_RS09045
uniprot id: D5EH59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS08100
gene id: 572547:AMICO_RS08100
uniprot id: D5EGM1
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS03320
gene id: 572547:AMICO_RS03320
uniprot id: D5EE13
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07765
gene id: 572547:AMICO_RS07765
uniprot id: D5EGF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

572547:AMICO RS02940
gene id: 572547:AMICO_RS02940
uniprot id: D5EDT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

572547:AMICO RS01295
gene id: 572547:AMICO_RS01295
uniprot id: D5ECX9
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

572547:AMICO RS02905
gene id: 572547:AMICO_RS02905
uniprot id: D5EDT0
names: Similarity
messages: Belongs to the peptidase A31 family.

572547:AMICO RS08735
gene id: 572547:AMICO_RS08735
uniprot id: D5EGZ8
names: Similarity
messages: Belongs to the polysaccharide synthase family.

572547:AMICO RS05915
gene id: 572547:AMICO_RS05915
uniprot id: D5EFF3
names: Similarity
messages: Belongs to the SAICAR synthetase family.

572547:AMICO RS07140
gene id: 572547:AMICO_RS07140
uniprot id: D5EG35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

572547:AMICO RS03640
gene id: 572547:AMICO_RS03640
uniprot id: D5EE74
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

572547:AMICO RS06300
gene id: 572547:AMICO_RS06300
uniprot id: D5EFM5
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

572547:AMICO RS08150
gene id: 572547:AMICO_RS08150
uniprot id: D5EGN1
names: Function
names: Similarity
messages: Belongs to the OMP decarboxylase family.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

572547:AMICO RS06515
gene id: 572547:AMICO_RS06515
uniprot id: D5EFR7
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572547:AMICO RS04525
gene id: 572547:AMICO_RS04525
uniprot id: D5EEN6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

572547:AMICO RS01955
gene id: 572547:AMICO_RS01955
uniprot id: D5ED99
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

572547:AMICO RS08790
gene id: 572547:AMICO_RS08790
uniprot id: D5EH09
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

572547:AMICO RS07665
gene id: 572547:AMICO_RS07665
uniprot id: D5EGD9
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

572547:AMICO RS00265
gene id: 572547:AMICO_RS00265
uniprot id: D5ECC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

572547:AMICO RS05590
gene id: 572547:AMICO_RS05590
uniprot id: D5EF85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS07980
gene id: 572547:AMICO_RS07980
uniprot id: D5EGJ8
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

572547:AMICO RS09655
gene id: 572547:AMICO_RS09655
uniprot id: D5EHH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of alpha-methyl-L-serine to D-alanine with tetrahydrofolate (THF) serving as the one-carbon carrier.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS03220
gene id: 572547:AMICO_RS03220
uniprot id: D5EDZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

572547:AMICO RS06245
gene id: 572547:AMICO_RS06245
uniprot id: D5EFL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

572547:AMICO RS05425
gene id: 572547:AMICO_RS05425
uniprot id: D5EF53
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

572547:AMICO RS03535
gene id: 572547:AMICO_RS03535
uniprot id: D5EE56
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS06835
gene id: 572547:AMICO_RS06835
uniprot id: D5EFX5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS00575
gene id: 572547:AMICO_RS00575
uniprot id: D5ECI6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

572547:AMICO RS01090
gene id: 572547:AMICO_RS01090
uniprot id: D5ECT8
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS00885
gene id: 572547:AMICO_RS00885
uniprot id: D5ECP8
names: Similarity
messages: Belongs to the acylphosphatase family.

572547:AMICO RS05005
gene id: 572547:AMICO_RS05005
uniprot id: D5EEX0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

572547:AMICO RS03700
gene id: 572547:AMICO_RS03700
uniprot id: D5EE86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

572547:AMICO RS03090
gene id: 572547:AMICO_RS03090
uniprot id: D5EDW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

572547:AMICO RS02605
gene id: 572547:AMICO_RS02605
uniprot id: D5EDM4
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

572547:AMICO RS02750
gene id: 572547:AMICO_RS02750
uniprot id: D5EDQ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

572547:AMICO RS09910
gene id: 572547:AMICO_RS09910
uniprot id: D5EF01
names: Similarity
messages: Belongs to the SUI1 family.

572547:AMICO RS07885
gene id: 572547:AMICO_RS07885
uniprot id: D5EGH9
names: Similarity
messages: Belongs to the CdaR family.

572547:AMICO RS01065
gene id: 572547:AMICO_RS01065
uniprot id: D5ECT3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07955
gene id: 572547:AMICO_RS07955
uniprot id: D5EGJ3
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

572547:AMICO RS03455
gene id: 572547:AMICO_RS03455
uniprot id: D5EE41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

572547:AMICO RS03020
gene id: 572547:AMICO_RS03020
uniprot id: D5EDV3
names: Similarity
messages: Belongs to the UPF0758 family.

572547:AMICO RS08305
gene id: 572547:AMICO_RS08305
uniprot id: D5EGR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

572547:AMICO RS08170
gene id: 572547:AMICO_RS08170
uniprot id: D5EGN5
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

572547:AMICO RS07180
gene id: 572547:AMICO_RS07180
uniprot id: D5EG43
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS03810
gene id: 572547:AMICO_RS03810
uniprot id: D5EEA7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

572547:AMICO RS00930
gene id: 572547:AMICO_RS00930
uniprot id: D5ECQ7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

572547:AMICO RS01725
gene id: 572547:AMICO_RS01725
uniprot id: D5ED51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

572547:AMICO RS06370
gene id: 572547:AMICO_RS06370
uniprot id: D5EFP0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

572547:AMICO RS05975
gene id: 572547:AMICO_RS05975
uniprot id: D5EFG5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06665
gene id: 572547:AMICO_RS06665
uniprot id: D5EFU5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

572547:AMICO RS09950
gene id: 572547:AMICO_RS09950
uniprot id: D5EFG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

572547:AMICO RS08920
gene id: 572547:AMICO_RS08920
uniprot id: D5EH34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

572547:AMICO RS03570
gene id: 572547:AMICO_RS03570
uniprot id: D5EE63
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

572547:AMICO RS08165
gene id: 572547:AMICO_RS08165
uniprot id: D5EGN4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06075
gene id: 572547:AMICO_RS06075
uniprot id: D5EFI3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

572547:AMICO RS02335
gene id: 572547:AMICO_RS02335
uniprot id: D5EDH0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

572547:AMICO RS08520
gene id: 572547:AMICO_RS08520
uniprot id: D5EGV6
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

572547:AMICO RS02885
gene id: 572547:AMICO_RS02885
uniprot id: D5EDS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

572547:AMICO RS05475
gene id: 572547:AMICO_RS05475
uniprot id: D5EF63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

572547:AMICO RS06445
gene id: 572547:AMICO_RS06445
uniprot id: D5EFQ3
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

572547:AMICO RS01465
gene id: 572547:AMICO_RS01465
uniprot id: D5ED10
names: Similarity
messages: Belongs to the NadC/ModD family.

572547:AMICO RS04410
gene id: 572547:AMICO_RS04410
uniprot id: D5EEL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

572547:AMICO RS05405
gene id: 572547:AMICO_RS05405
uniprot id: D5EF49
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01555
gene id: 572547:AMICO_RS01555
uniprot id: D5ED24
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

572547:AMICO RS08365
gene id: 572547:AMICO_RS08365
uniprot id: D5EGS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

572547:AMICO RS03280
gene id: 572547:AMICO_RS03280
uniprot id: D5EE04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

572547:AMICO RS03590
gene id: 572547:AMICO_RS03590
uniprot id: D5EE67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

572547:AMICO RS08915
gene id: 572547:AMICO_RS08915
uniprot id: D5EH33
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS00210
gene id: 572547:AMICO_RS00210
uniprot id: D5ECA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

572547:AMICO RS01720
gene id: 572547:AMICO_RS01720
uniprot id: D5ED50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

572547:AMICO RS07015
gene id: 572547:AMICO_RS07015
uniprot id: D5EG10
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

572547:AMICO RS05945
gene id: 572547:AMICO_RS05945
uniprot id: D5EFF9
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

572547:AMICO RS00295
gene id: 572547:AMICO_RS00295
uniprot id: D5ECC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS06115
gene id: 572547:AMICO_RS06115
uniprot id: D5EFJ1
names: Similarity
messages: Belongs to the bacterial secretin family.

572547:AMICO RS04440
gene id: 572547:AMICO_RS04440
uniprot id: D5EEL9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06765
gene id: 572547:AMICO_RS06765
uniprot id: D5EFW3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07820
gene id: 572547:AMICO_RS07820
uniprot id: D5EGG7
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

572547:AMICO RS05870
gene id: 572547:AMICO_RS05870
uniprot id: D5EFE4
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

572547:AMICO RS05245
gene id: 572547:AMICO_RS05245
uniprot id: D5EF17
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572547:AMICO RS03260
gene id: 572547:AMICO_RS03260
uniprot id: D5EE00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

572547:AMICO RS00500
gene id: 572547:AMICO_RS00500
uniprot id: D5ECH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

572547:AMICO RS06015
gene id: 572547:AMICO_RS06015
uniprot id: D5EFH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

572547:AMICO RS03165
gene id: 572547:AMICO_RS03165
uniprot id: D5EDY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

572547:AMICO RS04150
gene id: 572547:AMICO_RS04150
uniprot id: D5EEG5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06995
gene id: 572547:AMICO_RS06995
uniprot id: D5EG06
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

572547:AMICO RS02290
gene id: 572547:AMICO_RS02290
uniprot id: D5EDG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

572547:AMICO RS08175
gene id: 572547:AMICO_RS08175
uniprot id: D5EGN6
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

572547:AMICO RS03660
gene id: 572547:AMICO_RS03660
uniprot id: D5EE78
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

572547:AMICO RS05180
gene id: 572547:AMICO_RS05180
uniprot id: D5EF04
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

572547:AMICO RS02910
gene id: 572547:AMICO_RS02910
uniprot id: D5EDT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

572547:AMICO RS00005
gene id: 572547:AMICO_RS00005
uniprot id: D5EC68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

572547:AMICO RS08535
gene id: 572547:AMICO_RS08535
uniprot id: D5EGV9
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS00660
gene id: 572547:AMICO_RS00660
uniprot id: D5ECK3
names: Similarity
messages: Belongs to the PrpD family.

572547:AMICO RS01890
gene id: 572547:AMICO_RS01890
uniprot id: D5ED86
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS04460
gene id: 572547:AMICO_RS04460
uniprot id: D5EEM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

572547:AMICO RS02135
gene id: 572547:AMICO_RS02135
uniprot id: D5EDD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS05485
gene id: 572547:AMICO_RS05485
uniprot id: D5EF65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

572547:AMICO RS05110
gene id: 572547:AMICO_RS05110
uniprot id: D5EEZ1
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

572547:AMICO RS07145
gene id: 572547:AMICO_RS07145
uniprot id: D5EG36
names: Similarity
messages: Belongs to the HupF/HypC family.

572547:AMICO RS03400
gene id: 572547:AMICO_RS03400
uniprot id: D5EE30
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

572547:AMICO RS09915
gene id: 572547:AMICO_RS09915
uniprot id: D5EF02
names: Similarity
messages: Belongs to the Nudix hydrolase family.

572547:AMICO RS04245
gene id: 572547:AMICO_RS04245
uniprot id: D5EEI4
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

572547:AMICO RS02175
gene id: 572547:AMICO_RS02175
uniprot id: D5EDD8
names: Caution
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS05980
gene id: 572547:AMICO_RS05980
uniprot id: D5EFG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

572547:AMICO RS01115
gene id: 572547:AMICO_RS01115
uniprot id: D5ECU3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS09210
gene id: 572547:AMICO_RS09210
uniprot id: D5EH91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS03270
gene id: 572547:AMICO_RS03270
uniprot id: D5EE02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

572547:AMICO RS07345
gene id: 572547:AMICO_RS07345
uniprot id: D5EG76
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

572547:AMICO RS07230
gene id: 572547:AMICO_RS07230
uniprot id: D5EG53
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

572547:AMICO RS03740
gene id: 572547:AMICO_RS03740
uniprot id: D5EE94
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

572547:AMICO RS06575
gene id: 572547:AMICO_RS06575
uniprot id: D5EFS8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

572547:AMICO RS04130
gene id: 572547:AMICO_RS04130
uniprot id: D5EEG1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

572547:AMICO RS04570
gene id: 572547:AMICO_RS04570
uniprot id: D5EEP5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

572547:AMICO RS04105
gene id: 572547:AMICO_RS04105
uniprot id: D5EEF6
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

572547:AMICO RS04200
gene id: 572547:AMICO_RS04200
uniprot id: D5EEH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

572547:AMICO RS00480
gene id: 572547:AMICO_RS00480
uniprot id: D5ECG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572547:AMICO RS01845
gene id: 572547:AMICO_RS01845
uniprot id: D5ED76
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

572547:AMICO RS04550
gene id: 572547:AMICO_RS04550
uniprot id: D5EEP1
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

572547:AMICO RS04405
gene id: 572547:AMICO_RS04405
uniprot id: D5EEL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

572547:AMICO RS00845
gene id: 572547:AMICO_RS00845
uniprot id: D5ECP0
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS04420
gene id: 572547:AMICO_RS04420
uniprot id: D5EEL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

572547:AMICO RS09310
gene id: 572547:AMICO_RS09310
uniprot id: D5EHB0
names: Similarity
messages: Belongs to the DapA family.

572547:AMICO RS03150
gene id: 572547:AMICO_RS03150
uniprot id: D5EDX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

572547:AMICO RS03505
gene id: 572547:AMICO_RS03505
uniprot id: D5EE50
names: Subcellular Location Annotation
messages: Periplasm

572547:AMICO RS04320
gene id: 572547:AMICO_RS04320
uniprot id: D5EEJ7
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

572547:AMICO RS05950
gene id: 572547:AMICO_RS05950
uniprot id: D5EFG0
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

572547:AMICO RS04955
gene id: 572547:AMICO_RS04955
uniprot id: D5EEW0
names: Similarity
messages: Belongs to the ribF family.

572547:AMICO RS03045
gene id: 572547:AMICO_RS03045
uniprot id: D5EDV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

572547:AMICO RS06405
gene id: 572547:AMICO_RS06405
uniprot id: D5EFP6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

572547:AMICO RS01245
gene id: 572547:AMICO_RS01245
uniprot id: D5ECW9
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

572547:AMICO RS07870
gene id: 572547:AMICO_RS07870
uniprot id: D5EGH6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS06745
gene id: 572547:AMICO_RS06745
uniprot id: D5EFW0
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

572547:AMICO RS02600
gene id: 572547:AMICO_RS02600
uniprot id: D5EDM3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS01875
gene id: 572547:AMICO_RS01875
uniprot id: D5ED82
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

572547:AMICO RS05300
gene id: 572547:AMICO_RS05300
uniprot id: D5EF28
names: Similarity
messages: Belongs to the asp23 family.

572547:AMICO RS04215
gene id: 572547:AMICO_RS04215
uniprot id: D5EEH8
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

572547:AMICO RS05570
gene id: 572547:AMICO_RS05570
uniprot id: D5EF81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

572547:AMICO RS03840
gene id: 572547:AMICO_RS03840
uniprot id: D5EEB3
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

572547:AMICO RS00340
gene id: 572547:AMICO_RS00340
uniprot id: D5ECD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS00565
gene id: 572547:AMICO_RS00565
uniprot id: D5ECI4
names: Similarity
messages: Belongs to the UPF0597 family.

572547:AMICO RS06485
gene id: 572547:AMICO_RS06485
uniprot id: D5EFR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS01135
gene id: 572547:AMICO_RS01135
uniprot id: D5ECU7
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

572547:AMICO RS09680
gene id: 572547:AMICO_RS09680
uniprot id: D5EHI4
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.
messages: Cytoplasm

572547:AMICO RS00635
gene id: 572547:AMICO_RS00635
uniprot id: D5ECJ8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS01700
gene id: 572547:AMICO_RS01700
uniprot id: D5ED46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

572547:AMICO RS07620
gene id: 572547:AMICO_RS07620
uniprot id: D5EGD0
names: Caution
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

572547:AMICO RS07480
gene id: 572547:AMICO_RS07480
uniprot id: D5EGA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

572547:AMICO RS07930
gene id: 572547:AMICO_RS07930
uniprot id: D5EGI8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

572547:AMICO RS04000
gene id: 572547:AMICO_RS04000
uniprot id: D5EED6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS08550
gene id: 572547:AMICO_RS08550
uniprot id: D5EGW2
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

572547:AMICO RS01200
gene id: 572547:AMICO_RS01200
uniprot id: D5ECW0
names: Similarity
messages: Belongs to the peptidase C56 family.

572547:AMICO RS07010
gene id: 572547:AMICO_RS07010
uniprot id: D5EG09
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

572547:AMICO RS03555
gene id: 572547:AMICO_RS03555
uniprot id: D5EE60
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS03180
gene id: 572547:AMICO_RS03180
uniprot id: D5EDY4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

572547:AMICO RS04300
gene id: 572547:AMICO_RS04300
uniprot id: D5EEJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

572547:AMICO RS02355
gene id: 572547:AMICO_RS02355
uniprot id: D5EDH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS05910
gene id: 572547:AMICO_RS05910
uniprot id: D5EFF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

572547:AMICO RS05440
gene id: 572547:AMICO_RS05440
uniprot id: D5EF56
names: Similarity
messages: Belongs to the fabD family.

572547:AMICO RS00830
gene id: 572547:AMICO_RS00830
uniprot id: D5ECN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

572547:AMICO RS01575
gene id: 572547:AMICO_RS01575
uniprot id: D5ED27
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

572547:AMICO RS01675
gene id: 572547:AMICO_RS01675
uniprot id: D5ED40
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

572547:AMICO RS05075
gene id: 572547:AMICO_RS05075
uniprot id: D5EEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

572547:AMICO RS04240
gene id: 572547:AMICO_RS04240
uniprot id: D5EEI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

572547:AMICO RS08620
gene id: 572547:AMICO_RS08620
uniprot id: D5EGX6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS05355
gene id: 572547:AMICO_RS05355
uniprot id: D5EF39
names: Similarity
messages: Belongs to the FBPase class 2 family.

572547:AMICO RS02035
gene id: 572547:AMICO_RS02035
uniprot id: D5EDB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

572547:AMICO RS02220
gene id: 572547:AMICO_RS02220
uniprot id: D5EDE7
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

572547:AMICO RS02565
gene id: 572547:AMICO_RS02565
uniprot id: D5EDL6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS08685
gene id: 572547:AMICO_RS08685
uniprot id: D5EGY9
names: Similarity
messages: Belongs to the PrpD family.

572547:AMICO RS00585
gene id: 572547:AMICO_RS00585
uniprot id: D5ECI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

572547:AMICO RS01835
gene id: 572547:AMICO_RS01835
uniprot id: D5ED74
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS03230
gene id: 572547:AMICO_RS03230
uniprot id: D5EDZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

572547:AMICO RS00920
gene id: 572547:AMICO_RS00920
uniprot id: D5ECQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the encapsulin family. Family 1 subfamily.
messages: Encapsulin nanocompartment

572547:AMICO RS05050
gene id: 572547:AMICO_RS05050
uniprot id: D5EEX9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

572547:AMICO RS08965
gene id: 572547:AMICO_RS08965
uniprot id: D5EH43
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

572547:AMICO RS09720
gene id: 572547:AMICO_RS09720
uniprot id: D5EHJ2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05940
gene id: 572547:AMICO_RS05940
uniprot id: D5EFF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

572547:AMICO RS03245
gene id: 572547:AMICO_RS03245
uniprot id: D5EDZ7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

572547:AMICO RS07945
gene id: 572547:AMICO_RS07945
uniprot id: D5EGJ1
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

572547:AMICO RS03405
gene id: 572547:AMICO_RS03405
uniprot id: D5EE31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

572547:AMICO RS06095
gene id: 572547:AMICO_RS06095
uniprot id: D5EFI7
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01585
gene id: 572547:AMICO_RS01585
uniprot id: D5ED29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

572547:AMICO RS07630
gene id: 572547:AMICO_RS07630
uniprot id: D5EGD2
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

572547:AMICO RS05290
gene id: 572547:AMICO_RS05290
uniprot id: D5EF26
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

572547:AMICO RS07060
gene id: 572547:AMICO_RS07060
uniprot id: D5EG19
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

572547:AMICO RS06200
gene id: 572547:AMICO_RS06200
uniprot id: D5EFK7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

572547:AMICO RS04335
gene id: 572547:AMICO_RS04335
uniprot id: D5EEK0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS02130
gene id: 572547:AMICO_RS02130
uniprot id: D5EDC9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

572547:AMICO RS00050
gene id: 572547:AMICO_RS00050
uniprot id: D5EC78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

572547:AMICO RS02070
gene id: 572547:AMICO_RS02070
uniprot id: D5EDB6
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

572547:AMICO RS05035
gene id: 572547:AMICO_RS05035
uniprot id: D5EEX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

572547:AMICO RS06870
gene id: 572547:AMICO_RS06870
uniprot id: D5EFY2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

572547:AMICO RS01780
gene id: 572547:AMICO_RS01780
uniprot id: D5ED62
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

572547:AMICO RS08905
gene id: 572547:AMICO_RS08905
uniprot id: D5EH31
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05130
gene id: 572547:AMICO_RS05130
uniprot id: D5EEZ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

572547:AMICO RS04800
gene id: 572547:AMICO_RS04800
uniprot id: D5EET5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS08975
gene id: 572547:AMICO_RS08975
uniprot id: D5EH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

572547:AMICO RS06980
gene id: 572547:AMICO_RS06980
uniprot id: D5EG03
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

572547:AMICO RS01160
gene id: 572547:AMICO_RS01160
uniprot id: D5ECV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

572547:AMICO RS07225
gene id: 572547:AMICO_RS07225
uniprot id: D5EG52
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

572547:AMICO RS01110
gene id: 572547:AMICO_RS01110
uniprot id: D5ECU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

572547:AMICO RS00105
gene id: 572547:AMICO_RS00105
uniprot id: D5EC89
names: Similarity
messages: Belongs to the creatininase superfamily.

572547:AMICO RS01235
gene id: 572547:AMICO_RS01235
uniprot id: D5ECW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

572547:AMICO RS08075
gene id: 572547:AMICO_RS08075
uniprot id: D5EGL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

572547:AMICO RS00945
gene id: 572547:AMICO_RS00945
uniprot id: D5ECR0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

572547:AMICO RS08950
gene id: 572547:AMICO_RS08950
uniprot id: D5EH40
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS07165
gene id: 572547:AMICO_RS07165
uniprot id: D5EG40
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

572547:AMICO RS01475
gene id: 572547:AMICO_RS01475
uniprot id: D5ED12
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

572547:AMICO RS02755
gene id: 572547:AMICO_RS02755
uniprot id: D5EDQ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

572547:AMICO RS04115
gene id: 572547:AMICO_RS04115
uniprot id: D5EEF8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

572547:AMICO RS08180
gene id: 572547:AMICO_RS08180
uniprot id: D5EGN7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS05430
gene id: 572547:AMICO_RS05430
uniprot id: D5EF54
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

572547:AMICO RS05280
gene id: 572547:AMICO_RS05280
uniprot id: D5EF24
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

572547:AMICO RS04575
gene id: 572547:AMICO_RS04575
uniprot id: D5EEP6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

572547:AMICO RS06040
gene id: 572547:AMICO_RS06040
uniprot id: D5EFH8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS08980
gene id: 572547:AMICO_RS08980
uniprot id: D5EH46
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

572547:AMICO RS02685
gene id: 572547:AMICO_RS02685
uniprot id: D5EDP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS01580
gene id: 572547:AMICO_RS01580
uniprot id: D5ED28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

572547:AMICO RS02625
gene id: 572547:AMICO_RS02625
uniprot id: D5EDM8
names: Similarity
messages: Belongs to the RutC family.

572547:AMICO RS05575
gene id: 572547:AMICO_RS05575
uniprot id: D5EF82
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

572547:AMICO RS09670
gene id: 572547:AMICO_RS09670
uniprot id: D5EHI2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

572547:AMICO RS04585
gene id: 572547:AMICO_RS04585
uniprot id: D5EEP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

572547:AMICO RS09270
gene id: 572547:AMICO_RS09270
uniprot id: D5EHA2
names: Similarity
messages: Belongs to the Nudix hydrolase family.

572547:AMICO RS03265
gene id: 572547:AMICO_RS03265
uniprot id: D5EE01
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

572547:AMICO RS08560
gene id: 572547:AMICO_RS08560
uniprot id: D5EGW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

572547:AMICO RS06310
gene id: 572547:AMICO_RS06310
uniprot id: D5EFM7
names: Similarity
messages: Belongs to the peptidase M18 family.

572547:AMICO RS04980
gene id: 572547:AMICO_RS04980
uniprot id: D5EEW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

572547:AMICO RS00235
gene id: 572547:AMICO_RS00235
uniprot id: D5ECB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS07320
gene id: 572547:AMICO_RS07320
uniprot id: D5EG71
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

572547:AMICO RS07090
gene id: 572547:AMICO_RS07090
uniprot id: D5EG25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS05385
gene id: 572547:AMICO_RS05385
uniprot id: D5EF45
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

572547:AMICO RS02880
gene id: 572547:AMICO_RS02880
uniprot id: D5EDS6
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

572547:AMICO RS08080
gene id: 572547:AMICO_RS08080
uniprot id: D5EGL7
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

572547:AMICO RS04135
gene id: 572547:AMICO_RS04135
uniprot id: D5EEG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

572547:AMICO RS01855
gene id: 572547:AMICO_RS01855
uniprot id: D5ED78
names: Similarity
messages: Belongs to the AAA ATPase family.

572547:AMICO RS05595
gene id: 572547:AMICO_RS05595
uniprot id: D5EF86
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

572547:AMICO RS09855
gene id: 572547:AMICO_RS09855
uniprot id: D5EE82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

572547:AMICO RS08445
gene id: 572547:AMICO_RS08445
uniprot id: D5EGU0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

572547:AMICO RS00190
gene id: 572547:AMICO_RS00190
uniprot id: D5ECA6
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.

572547:AMICO RS08020
gene id: 572547:AMICO_RS08020
uniprot id: D5EGK5
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

572547:AMICO RS04560
gene id: 572547:AMICO_RS04560
uniprot id: D5EEP3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

572547:AMICO RS08065
gene id: 572547:AMICO_RS08065
uniprot id: D5EGL4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

572547:AMICO RS05875
gene id: 572547:AMICO_RS05875
uniprot id: D5EFE5
names: Caution
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS07075
gene id: 572547:AMICO_RS07075
uniprot id: D5EG22
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

572547:AMICO RS04450
gene id: 572547:AMICO_RS04450
uniprot id: D5EEM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

572547:AMICO RS05240
gene id: 572547:AMICO_RS05240
uniprot id: D5EF16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

572547:AMICO RS04500
gene id: 572547:AMICO_RS04500
uniprot id: D5EEN1
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the LacAB/RpiB family.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

572547:AMICO RS00410
gene id: 572547:AMICO_RS00410
uniprot id: D5ECF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

572547:AMICO RS07435
gene id: 572547:AMICO_RS07435
uniprot id: D5EG93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

572547:AMICO RS03890
gene id: 572547:AMICO_RS03890
uniprot id: D5EEB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS00315
gene id: 572547:AMICO_RS00315
uniprot id: D5ECD0
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01070
gene id: 572547:AMICO_RS01070
uniprot id: D5ECT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

572547:AMICO RS09130
gene id: 572547:AMICO_RS09130
uniprot id: D5EH75
names: Similarity
messages: Belongs to the DSD1 family.

572547:AMICO RS09870
gene id: 572547:AMICO_RS09870
uniprot id: D5EEC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

572547:AMICO RS05520
gene id: 572547:AMICO_RS05520
uniprot id: D5EF71
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

572547:AMICO RS08225
gene id: 572547:AMICO_RS08225
uniprot id: D5EGP6
names: Similarity
messages: Belongs to the peptidase M20A family.

572547:AMICO RS05515
gene id: 572547:AMICO_RS05515
uniprot id: D5EF70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

572547:AMICO RS09890
gene id: 572547:AMICO_RS09890
uniprot id: D5EER6
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05925
gene id: 572547:AMICO_RS05925
uniprot id: D5EFF5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572547:AMICO RS08155
gene id: 572547:AMICO_RS08155
uniprot id: D5EGN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS00975
gene id: 572547:AMICO_RS00975
uniprot id: D5ECR6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS03710
gene id: 572547:AMICO_RS03710
uniprot id: D5EE88
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

572547:AMICO RS01330
gene id: 572547:AMICO_RS01330
uniprot id: D5ECY6
names: Similarity
messages: Belongs to the universal stress protein A family.

572547:AMICO RS05865
gene id: 572547:AMICO_RS05865
uniprot id: D5EFE3
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

572547:AMICO RS02505
gene id: 572547:AMICO_RS02505
uniprot id: D5EDK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

572547:AMICO RS06910
gene id: 572547:AMICO_RS06910
uniprot id: D5EFY9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

572547:AMICO RS02065
gene id: 572547:AMICO_RS02065
uniprot id: D5EDB5
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS09580
gene id: 572547:AMICO_RS09580
uniprot id: D5EHG6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

572547:AMICO RS03420
gene id: 572547:AMICO_RS03420
uniprot id: D5EE34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

572547:AMICO RS04195
gene id: 572547:AMICO_RS04195
uniprot id: D5EEH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

572547:AMICO RS07670
gene id: 572547:AMICO_RS07670
uniprot id: D5EGE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

572547:AMICO RS04260
gene id: 572547:AMICO_RS04260
uniprot id: D5EEI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

572547:AMICO RS01020
gene id: 572547:AMICO_RS01020
uniprot id: D5ECS4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS09235
gene id: 572547:AMICO_RS09235
uniprot id: D5EH95
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS00510
gene id: 572547:AMICO_RS00510
uniprot id: D5ECH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

572547:AMICO RS06080
gene id: 572547:AMICO_RS06080
uniprot id: D5EFI4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

572547:AMICO RS03545
gene id: 572547:AMICO_RS03545
uniprot id: D5EE58
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

572547:AMICO RS01225
gene id: 572547:AMICO_RS01225
uniprot id: D5ECW5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

572547:AMICO RS07875
gene id: 572547:AMICO_RS07875
uniprot id: D5EGH7
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS08880
gene id: 572547:AMICO_RS08880
uniprot id: D5EH27
names: Similarity
messages: Belongs to the peptidase M20A family.

572547:AMICO RS09165
gene id: 572547:AMICO_RS09165
uniprot id: D5EH82
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

572547:AMICO RS07845
gene id: 572547:AMICO_RS07845
uniprot id: D5EGH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

572547:AMICO RS07610
gene id: 572547:AMICO_RS07610
uniprot id: D5EGC8
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

572547:AMICO RS09845
gene id: 572547:AMICO_RS09845
uniprot id: D5EDV5
names: Similarity
messages: Belongs to the MreC family.

572547:AMICO RS04920
gene id: 572547:AMICO_RS04920
uniprot id: D5EEV4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

572547:AMICO RS09415
gene id: 572547:AMICO_RS09415
uniprot id: D5EHD2
names: Similarity
messages: Belongs to the ParB family.

572547:AMICO RS00810
gene id: 572547:AMICO_RS00810
uniprot id: D5ECN3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS00825
gene id: 572547:AMICO_RS00825
uniprot id: D5ECN6
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.

572547:AMICO RS07200
gene id: 572547:AMICO_RS07200
uniprot id: D5EG47
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

572547:AMICO RS05920
gene id: 572547:AMICO_RS05920
uniprot id: D5EFF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

572547:AMICO RS07635
gene id: 572547:AMICO_RS07635
uniprot id: D5EGD3
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

572547:AMICO RS09980
gene id: 572547:AMICO_RS09980
uniprot id: D5EGF8
names: Similarity
messages: Belongs to the DprA/Smf family.

572547:AMICO RS02590
gene id: 572547:AMICO_RS02590
uniprot id: D5EDM1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

572547:AMICO RS08940
gene id: 572547:AMICO_RS08940
uniprot id: D5EH38
names: Function
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

572547:AMICO RS03530
gene id: 572547:AMICO_RS03530
uniprot id: D5EE55
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

572547:AMICO RS02265
gene id: 572547:AMICO_RS02265
uniprot id: D5EDF6
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS01865
gene id: 572547:AMICO_RS01865
uniprot id: D5ED80
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

572547:AMICO RS03210
gene id: 572547:AMICO_RS03210
uniprot id: D5EDZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

572547:AMICO RS06035
gene id: 572547:AMICO_RS06035
uniprot id: D5EFH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

572547:AMICO RS09125
gene id: 572547:AMICO_RS09125
uniprot id: D5EH74
names: Similarity
messages: Belongs to the LarC family.

572547:AMICO RS07890
gene id: 572547:AMICO_RS07890
uniprot id: D5EGI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

572547:AMICO RS08070
gene id: 572547:AMICO_RS08070
uniprot id: D5EGL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

572547:AMICO RS08810
gene id: 572547:AMICO_RS08810
uniprot id: D5EH13
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

572547:AMICO RS06790
gene id: 572547:AMICO_RS06790
uniprot id: D5EFW8
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

572547:AMICO RS07785
gene id: 572547:AMICO_RS07785
uniprot id: D5EGG0
names: Similarity
messages: Belongs to the UPF0102 family.

572547:AMICO RS08280
gene id: 572547:AMICO_RS08280
uniprot id: D5EGQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

572547:AMICO RS03105
gene id: 572547:AMICO_RS03105
uniprot id: D5EDX0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

572547:AMICO RS00055
gene id: 572547:AMICO_RS00055
uniprot id: D5EC79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

572547:AMICO RS00505
gene id: 572547:AMICO_RS00505
uniprot id: D5ECH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

572547:AMICO RS08555
gene id: 572547:AMICO_RS08555
uniprot id: D5EGW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

572547:AMICO RS03445
gene id: 572547:AMICO_RS03445
uniprot id: D5EE39
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02635
gene id: 572547:AMICO_RS02635
uniprot id: D5EDN0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

572547:AMICO RS03200
gene id: 572547:AMICO_RS03200
uniprot id: D5EDY8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

572547:AMICO RS06800
gene id: 572547:AMICO_RS06800
uniprot id: D5EFX0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

572547:AMICO RS04125
gene id: 572547:AMICO_RS04125
uniprot id: D5EEG0
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

572547:AMICO RS08570
gene id: 572547:AMICO_RS08570
uniprot id: D5EGW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

572547:AMICO RS00680
gene id: 572547:AMICO_RS00680
uniprot id: D5ECK7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS07175
gene id: 572547:AMICO_RS07175
uniprot id: D5EG42
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

572547:AMICO RS09550
gene id: 572547:AMICO_RS09550
uniprot id: D5EHF9
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS04170
gene id: 572547:AMICO_RS04170
uniprot id: D5EEG9
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS03585
gene id: 572547:AMICO_RS03585
uniprot id: D5EE66
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS06465
gene id: 572547:AMICO_RS06465
uniprot id: D5EFQ7
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02870
gene id: 572547:AMICO_RS02870
uniprot id: D5EDS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

572547:AMICO RS01150
gene id: 572547:AMICO_RS01150
uniprot id: D5ECV0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

572547:AMICO RS06430
gene id: 572547:AMICO_RS06430
uniprot id: D5EFQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572547:AMICO RS00520
gene id: 572547:AMICO_RS00520
uniprot id: D5ECH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

572547:AMICO RS09555
gene id: 572547:AMICO_RS09555
uniprot id: D5EHG0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS05525
gene id: 572547:AMICO_RS05525
uniprot id: D5EF72
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

572547:AMICO RS03205
gene id: 572547:AMICO_RS03205
uniprot id: D5EDY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

572547:AMICO RS07790
gene id: 572547:AMICO_RS07790
uniprot id: D5EGG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

572547:AMICO RS08985
gene id: 572547:AMICO_RS08985
uniprot id: D5EH47
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

572547:AMICO RS05070
gene id: 572547:AMICO_RS05070
uniprot id: D5EEY3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS08300
gene id: 572547:AMICO_RS08300
uniprot id: D5EGR0
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05350
gene id: 572547:AMICO_RS05350
uniprot id: D5EF38
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

572547:AMICO RS02920
gene id: 572547:AMICO_RS02920
uniprot id: D5EDT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

572547:AMICO RS08825
gene id: 572547:AMICO_RS08825
uniprot id: D5EH16
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

572547:AMICO RS08610
gene id: 572547:AMICO_RS08610
uniprot id: D5EGX4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS07310
gene id: 572547:AMICO_RS07310
uniprot id: D5EG69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

572547:AMICO RS05335
gene id: 572547:AMICO_RS05335
uniprot id: D5EF35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06595
gene id: 572547:AMICO_RS06595
uniprot id: D5EFT1
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS06165
gene id: 572547:AMICO_RS06165
uniprot id: D5EFK1
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

572547:AMICO RS00540
gene id: 572547:AMICO_RS00540
uniprot id: D5ECH9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ApbE family.
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

572547:AMICO RS06535
gene id: 572547:AMICO_RS06535
uniprot id: D5EFS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

572547:AMICO RS00290
gene id: 572547:AMICO_RS00290
uniprot id: D5ECC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

572547:AMICO RS05550
gene id: 572547:AMICO_RS05550
uniprot id: D5EF77
names: Similarity
messages: Belongs to the RemA family.

572547:AMICO RS06440
gene id: 572547:AMICO_RS06440
uniprot id: D5EFQ2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07215
gene id: 572547:AMICO_RS07215
uniprot id: D5EG50
names: Similarity
messages: Belongs to the glutamine synthetase family.

572547:AMICO RS08400
gene id: 572547:AMICO_RS08400
uniprot id: D5EGT1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

572547:AMICO RS05415
gene id: 572547:AMICO_RS05415
uniprot id: D5EF51
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

572547:AMICO RS04315
gene id: 572547:AMICO_RS04315
uniprot id: D5EEJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

572547:AMICO RS07170
gene id: 572547:AMICO_RS07170
uniprot id: D5EG41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

572547:AMICO RS04075
gene id: 572547:AMICO_RS04075
uniprot id: D5EEF1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

572547:AMICO RS09320
gene id: 572547:AMICO_RS09320
uniprot id: D5EHB2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS00110
gene id: 572547:AMICO_RS00110
uniprot id: D5EC90
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two zinc ions.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Cytoplasm

572547:AMICO RS01250
gene id: 572547:AMICO_RS01250
uniprot id: D5ECX0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

572547:AMICO RS04735
gene id: 572547:AMICO_RS04735
uniprot id: D5EES5
names: Similarity
messages: Belongs to the glutamate synthase family.

572547:AMICO RS05025
gene id: 572547:AMICO_RS05025
uniprot id: D5EEX4
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

572547:AMICO RS04350
gene id: 572547:AMICO_RS04350
uniprot id: D5EEK3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

572547:AMICO RS05000
gene id: 572547:AMICO_RS05000
uniprot id: D5EEW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

572547:AMICO RS01745
gene id: 572547:AMICO_RS01745
uniprot id: D5ED55
names: Similarity
messages: Belongs to the bacterial glucokinase family.

572547:AMICO RS01265
gene id: 572547:AMICO_RS01265
uniprot id: D5ECX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS08675
gene id: 572547:AMICO_RS08675
uniprot id: D5EGY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572547:AMICO RS00045
gene id: 572547:AMICO_RS00045
uniprot id: D5EC77
names: Subunit
messages: Homodimer.

572547:AMICO RS02980
gene id: 572547:AMICO_RS02980
uniprot id: D5EDU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

572547:AMICO RS09425
gene id: 572547:AMICO_RS09425
uniprot id: D5EHD4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

572547:AMICO RS06030
gene id: 572547:AMICO_RS06030
uniprot id: D5EFH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

572547:AMICO RS03060
gene id: 572547:AMICO_RS03060
uniprot id: D5EDW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

572547:AMICO RS09085
gene id: 572547:AMICO_RS09085
uniprot id: D5EH66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS04960
gene id: 572547:AMICO_RS04960
uniprot id: D5EEW1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

572547:AMICO RS08310
gene id: 572547:AMICO_RS08310
uniprot id: D5EGR2
names: Similarity
messages: Belongs to the peptidase C69 family.

572547:AMICO RS05480
gene id: 572547:AMICO_RS05480
uniprot id: D5EF64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS00180
gene id: 572547:AMICO_RS00180
uniprot id: D5ECA4
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

572547:AMICO RS09965
gene id: 572547:AMICO_RS09965
uniprot id: D5EFL2
names: Similarity
messages: Belongs to the universal stress protein A family.

572547:AMICO RS04100
gene id: 572547:AMICO_RS04100
uniprot id: D5EEF5
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

572547:AMICO RS06925
gene id: 572547:AMICO_RS06925
uniprot id: D5EFZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

572547:AMICO RS07530
gene id: 572547:AMICO_RS07530
uniprot id: D5EGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

572547:AMICO RS03845
gene id: 572547:AMICO_RS03845
uniprot id: D5EEB4
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

572547:AMICO RS09525
gene id: 572547:AMICO_RS09525
uniprot id: D5EHF4
names: Similarity
messages: Belongs to the AOR/FOR family.

572547:AMICO RS06045
gene id: 572547:AMICO_RS06045
uniprot id: D5EFH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

572547:AMICO RS08590
gene id: 572547:AMICO_RS08590
uniprot id: D5EGX0
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

572547:AMICO RS05895
gene id: 572547:AMICO_RS05895
uniprot id: D5EFE9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

572547:AMICO RS00255
gene id: 572547:AMICO_RS00255
uniprot id: D5ECB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Membrane

572547:AMICO RS09050
gene id: 572547:AMICO_RS09050
uniprot id: D5EH60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS06395
gene id: 572547:AMICO_RS06395
uniprot id: D5EFP4
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

572547:AMICO RS06470
gene id: 572547:AMICO_RS06470
uniprot id: D5EFQ8
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02415
gene id: 572547:AMICO_RS02415
uniprot id: D5EDI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

572547:AMICO RS03325
gene id: 572547:AMICO_RS03325
uniprot id: D5EE14
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06000
gene id: 572547:AMICO_RS06000
uniprot id: D5EFH0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

572547:AMICO RS03830
gene id: 572547:AMICO_RS03830
uniprot id: D5EEB1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

572547:AMICO RS00220
gene id: 572547:AMICO_RS00220
uniprot id: D5ECB1
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

572547:AMICO RS00040
gene id: 572547:AMICO_RS00040
uniprot id: D5EC76
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

572547:AMICO RS04490
gene id: 572547:AMICO_RS04490
uniprot id: D5EEM9
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

572547:AMICO RS00225
gene id: 572547:AMICO_RS00225
uniprot id: D5ECB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS00650
gene id: 572547:AMICO_RS00650
uniprot id: D5ECK1
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

572547:AMICO RS04155
gene id: 572547:AMICO_RS04155
uniprot id: D5EEG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

572547:AMICO RS03765
gene id: 572547:AMICO_RS03765
uniprot id: D5EE98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

572547:AMICO RS07515
gene id: 572547:AMICO_RS07515
uniprot id: D5EGA9
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS04580
gene id: 572547:AMICO_RS04580
uniprot id: D5EEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

572547:AMICO RS03235
gene id: 572547:AMICO_RS03235
uniprot id: D5EDZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

572547:AMICO RS00185
gene id: 572547:AMICO_RS00185
uniprot id: D5ECA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS07300
gene id: 572547:AMICO_RS07300
uniprot id: D5EG67
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS03985
gene id: 572547:AMICO_RS03985
uniprot id: D5EED4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

572547:AMICO RS03215
gene id: 572547:AMICO_RS03215
uniprot id: D5EDZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

572547:AMICO RS06100
gene id: 572547:AMICO_RS06100
uniprot id: D5EFI8
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS03095
gene id: 572547:AMICO_RS03095
uniprot id: D5EDW8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS02210
gene id: 572547:AMICO_RS02210
uniprot id: D5EDE5
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

572547:AMICO RS01715
gene id: 572547:AMICO_RS01715
uniprot id: D5ED49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

572547:AMICO RS01370
gene id: 572547:AMICO_RS01370
uniprot id: D5ECZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS08900
gene id: 572547:AMICO_RS08900
uniprot id: D5EH30
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS05055
gene id: 572547:AMICO_RS05055
uniprot id: D5EEY0
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

572547:AMICO RS05960
gene id: 572547:AMICO_RS05960
uniprot id: D5EFG2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

572547:AMICO RS09225
gene id: 572547:AMICO_RS09225
uniprot id: D5EH93
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS09605
gene id: 572547:AMICO_RS09605
uniprot id: D5EHH1
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

572547:AMICO RS04285
gene id: 572547:AMICO_RS04285
uniprot id: D5EEJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

572547:AMICO RS08015
gene id: 572547:AMICO_RS08015
uniprot id: D5EGK4
names: Similarity
messages: Belongs to the BMP lipoprotein family.

572547:AMICO RS01595
gene id: 572547:AMICO_RS01595
uniprot id: D5ED31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

572547:AMICO RS00420
gene id: 572547:AMICO_RS00420
uniprot id: D5ECF2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

572547:AMICO RS08185
gene id: 572547:AMICO_RS08185
uniprot id: D5EGN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

572547:AMICO RS02745
gene id: 572547:AMICO_RS02745
uniprot id: D5EDQ4
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

572547:AMICO RS03160
gene id: 572547:AMICO_RS03160
uniprot id: D5EDY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

572547:AMICO RS04255
gene id: 572547:AMICO_RS04255
uniprot id: D5EEI6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

572547:AMICO RS04025
gene id: 572547:AMICO_RS04025
uniprot id: D5EEE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

572547:AMICO RS06840
gene id: 572547:AMICO_RS06840
uniprot id: D5EFX6
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS04390
gene id: 572547:AMICO_RS04390
uniprot id: D5EEL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

572547:AMICO RS09110
gene id: 572547:AMICO_RS09110
uniprot id: D5EH71
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

572547:AMICO RS09750
gene id: 572547:AMICO_RS09750
uniprot id: D5ECL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

572547:AMICO RS01490
gene id: 572547:AMICO_RS01490
uniprot id: D5ED15
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

572547:AMICO RS01415
gene id: 572547:AMICO_RS01415
uniprot id: D5ED00
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

572547:AMICO RS06335
gene id: 572547:AMICO_RS06335
uniprot id: D5EFN3
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

572547:AMICO RS02965
gene id: 572547:AMICO_RS02965
uniprot id: D5EDU2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

572547:AMICO RS08690
gene id: 572547:AMICO_RS08690
uniprot id: D5EGZ0
names: Similarity
messages: Belongs to the PrpD family.

572547:AMICO RS05065
gene id: 572547:AMICO_RS05065
uniprot id: D5EEY2
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

572547:AMICO RS07780
gene id: 572547:AMICO_RS07780
uniprot id: D5EGF9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

572547:AMICO RS03140
gene id: 572547:AMICO_RS03140
uniprot id: D5EDX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

572547:AMICO RS04210
gene id: 572547:AMICO_RS04210
uniprot id: D5EEH7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

572547:AMICO RS00095
gene id: 572547:AMICO_RS00095
uniprot id: D5EC87
names: Similarity
messages: Belongs to the Fur family.

572547:AMICO RS07355
gene id: 572547:AMICO_RS07355
uniprot id: D5EG78
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

572547:AMICO RS00970
gene id: 572547:AMICO_RS00970
uniprot id: D5ECR5
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07975
gene id: 572547:AMICO_RS07975
uniprot id: D5EGJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

572547:AMICO RS00645
gene id: 572547:AMICO_RS00645
uniprot id: D5ECK0
names: Similarity
messages: Belongs to the class-I fumarase family.

572547:AMICO RS07605
gene id: 572547:AMICO_RS07605
uniprot id: D5EGC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

572547:AMICO RS08700
gene id: 572547:AMICO_RS08700
uniprot id: D5EGZ2
names: Similarity
messages: Belongs to the PrpD family.

572547:AMICO RS03290
gene id: 572547:AMICO_RS03290
uniprot id: D5EE07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

572547:AMICO RS03565
gene id: 572547:AMICO_RS03565
uniprot id: D5EE62
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

572547:AMICO RS01120
gene id: 572547:AMICO_RS01120
uniprot id: D5ECU4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS00425
gene id: 572547:AMICO_RS00425
uniprot id: D5ECF3
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

572547:AMICO RS01290
gene id: 572547:AMICO_RS01290
uniprot id: D5ECX8
names: Similarity
messages: Belongs to the universal stress protein A family.

572547:AMICO RS00010
gene id: 572547:AMICO_RS00010
uniprot id: D5EC69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

572547:AMICO RS09295
gene id: 572547:AMICO_RS09295
uniprot id: D5EHA7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

572547:AMICO RS05100
gene id: 572547:AMICO_RS05100
uniprot id: D5EEY9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS01350
gene id: 572547:AMICO_RS01350
uniprot id: D5ECZ0
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS04185
gene id: 572547:AMICO_RS04185
uniprot id: D5EEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

572547:AMICO RS04330
gene id: 572547:AMICO_RS04330
uniprot id: D5EEJ9
names: Similarity
messages: Belongs to the TlyA family.

572547:AMICO RS07720
gene id: 572547:AMICO_RS07720
uniprot id: D5EGE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

572547:AMICO RS02100
gene id: 572547:AMICO_RS02100
uniprot id: D5EDC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS03010
gene id: 572547:AMICO_RS03010
uniprot id: D5EDV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS07240
gene id: 572547:AMICO_RS07240
uniprot id: D5EG55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

572547:AMICO RS06475
gene id: 572547:AMICO_RS06475
uniprot id: D5EFQ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS07750
gene id: 572547:AMICO_RS07750
uniprot id: D5EGF3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

572547:AMICO RS04455
gene id: 572547:AMICO_RS04455
uniprot id: D5EEM2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS00580
gene id: 572547:AMICO_RS00580
uniprot id: D5ECI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

572547:AMICO RS02455
gene id: 572547:AMICO_RS02455
uniprot id: D5EDJ4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

572547:AMICO RS01480
gene id: 572547:AMICO_RS01480
uniprot id: D5ED13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

572547:AMICO RS00325
gene id: 572547:AMICO_RS00325
uniprot id: D5ECD2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05420
gene id: 572547:AMICO_RS05420
uniprot id: D5EF52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

572547:AMICO RS08005
gene id: 572547:AMICO_RS08005
uniprot id: D5EGK2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05230
gene id: 572547:AMICO_RS05230
uniprot id: D5EF14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

572547:AMICO RS09360
gene id: 572547:AMICO_RS09360
uniprot id: D5EHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

572547:AMICO RS02045
gene id: 572547:AMICO_RS02045
uniprot id: D5EDB3
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

572547:AMICO RS03450
gene id: 572547:AMICO_RS03450
uniprot id: D5EE40
names: Similarity
messages: Belongs to the band 7/mec-2 family.

572547:AMICO RS02010
gene id: 572547:AMICO_RS02010
uniprot id: D5EDA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

572547:AMICO RS01170
gene id: 572547:AMICO_RS01170
uniprot id: D5ECV4
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS00880
gene id: 572547:AMICO_RS00880
uniprot id: D5ECP7
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS08410
gene id: 572547:AMICO_RS08410
uniprot id: D5EGT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

572547:AMICO RS08390
gene id: 572547:AMICO_RS08390
uniprot id: D5EGS9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS09315
gene id: 572547:AMICO_RS09315
uniprot id: D5EHB1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS05450
gene id: 572547:AMICO_RS05450
uniprot id: D5EF58
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

572547:AMICO RS08475
gene id: 572547:AMICO_RS08475
uniprot id: D5EGU6
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

572547:AMICO RS04685
gene id: 572547:AMICO_RS04685
uniprot id: D5EER5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS01645
gene id: 572547:AMICO_RS01645
uniprot id: D5ED34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Membrane

572547:AMICO RS05315
gene id: 572547:AMICO_RS05315
uniprot id: D5EF31
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS03965
gene id: 572547:AMICO_RS03965
uniprot id: D5EED0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell inner membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

572547:AMICO RS07925
gene id: 572547:AMICO_RS07925
uniprot id: D5EGI7
names: Similarity
messages: Belongs to the peptidase A31 family.

572547:AMICO RS07030
gene id: 572547:AMICO_RS07030
uniprot id: D5EG13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS09035
gene id: 572547:AMICO_RS09035
uniprot id: D5EH57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

572547:AMICO RS07400
gene id: 572547:AMICO_RS07400
uniprot id: D5EG87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

572547:AMICO RS00770
gene id: 572547:AMICO_RS00770
uniprot id: D5ECM5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS04465
gene id: 572547:AMICO_RS04465
uniprot id: D5EEM4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

572547:AMICO RS00955
gene id: 572547:AMICO_RS00955
uniprot id: D5ECR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS00485
gene id: 572547:AMICO_RS00485
uniprot id: D5ECG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

572547:AMICO RS05885
gene id: 572547:AMICO_RS05885
uniprot id: D5EFE7
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

572547:AMICO RS09405
gene id: 572547:AMICO_RS09405
uniprot id: D5EHC9
names: Similarity
messages: Belongs to the IMPACT family.

572547:AMICO RS02770
gene id: 572547:AMICO_RS02770
uniprot id: D5EDQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

572547:AMICO RS08145
gene id: 572547:AMICO_RS08145
uniprot id: D5EGN0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS06885
gene id: 572547:AMICO_RS06885
uniprot id: D5EFY5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

572547:AMICO RS07425
gene id: 572547:AMICO_RS07425
uniprot id: D5EG91
names: Similarity
messages: Belongs to the peptidase S41A family.

572547:AMICO RS08680
gene id: 572547:AMICO_RS08680
uniprot id: D5EGY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572547:AMICO RS05265
gene id: 572547:AMICO_RS05265
uniprot id: D5EF21
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

572547:AMICO RS01550
gene id: 572547:AMICO_RS01550
uniprot id: D5ED23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

572547:AMICO RS05330
gene id: 572547:AMICO_RS05330
uniprot id: D5EF34
names: Similarity
messages: Belongs to the peptidase S16 family.

572547:AMICO RS02650
gene id: 572547:AMICO_RS02650
uniprot id: D5EDN4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

572547:AMICO RS02830
gene id: 572547:AMICO_RS02830
uniprot id: D5EDS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

572547:AMICO RS05015
gene id: 572547:AMICO_RS05015
uniprot id: D5EEX2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS04680
gene id: 572547:AMICO_RS04680
uniprot id: D5EER4
names: Similarity
messages: Belongs to the UPF0597 family.

572547:AMICO RS01975
gene id: 572547:AMICO_RS01975
uniprot id: D5EDA3
names: Similarity
messages: Belongs to the CinA family.

572547:AMICO RS06600
gene id: 572547:AMICO_RS06600
uniprot id: D5EFT2
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS08805
gene id: 572547:AMICO_RS08805
uniprot id: D5EH12
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01360
gene id: 572547:AMICO_RS01360
uniprot id: D5ECZ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS05250
gene id: 572547:AMICO_RS05250
uniprot id: D5EF18
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

572547:AMICO RS02200
gene id: 572547:AMICO_RS02200
uniprot id: D5EDE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

572547:AMICO RS03195
gene id: 572547:AMICO_RS03195
uniprot id: D5EDY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

572547:AMICO RS07595
gene id: 572547:AMICO_RS07595
uniprot id: D5EGC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

572547:AMICO RS04375
gene id: 572547:AMICO_RS04375
uniprot id: D5EEK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell inner membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

572547:AMICO RS01930
gene id: 572547:AMICO_RS01930
uniprot id: D5ED94
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

572547:AMICO RS08270
gene id: 572547:AMICO_RS08270
uniprot id: D5EGQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

572547:AMICO RS00940
gene id: 572547:AMICO_RS00940
uniprot id: D5ECQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

572547:AMICO RS06330
gene id: 572547:AMICO_RS06330
uniprot id: D5EFN2
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

572547:AMICO RS05955
gene id: 572547:AMICO_RS05955
uniprot id: D5EFG1
names: Similarity
messages: Belongs to the GARS family.

572547:AMICO RS09395
gene id: 572547:AMICO_RS09395
uniprot id: D5EHC7
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

572547:AMICO RS02765
gene id: 572547:AMICO_RS02765
uniprot id: D5EDQ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

572547:AMICO RS00380
gene id: 572547:AMICO_RS00380
uniprot id: D5ECE4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

572547:AMICO RS04035
gene id: 572547:AMICO_RS04035
uniprot id: D5EEE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

572547:AMICO RS01210
gene id: 572547:AMICO_RS01210
uniprot id: D5ECW2
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

572547:AMICO RS03255
gene id: 572547:AMICO_RS03255
uniprot id: D5EDZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572547:AMICO RS00475
gene id: 572547:AMICO_RS00475
uniprot id: D5ECG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

572547:AMICO RS07045
gene id: 572547:AMICO_RS07045
uniprot id: D5EG16
names: Function
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.

572547:AMICO RS03730
gene id: 572547:AMICO_RS03730
uniprot id: D5EE92
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

572547:AMICO RS03835
gene id: 572547:AMICO_RS03835
uniprot id: D5EEB2
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

572547:AMICO RS01230
gene id: 572547:AMICO_RS01230
uniprot id: D5ECW6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

572547:AMICO RS05275
gene id: 572547:AMICO_RS05275
uniprot id: D5EF23
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

572547:AMICO RS09090
gene id: 572547:AMICO_RS09090
uniprot id: D5EH67
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

572547:AMICO RS02715
gene id: 572547:AMICO_RS02715
uniprot id: D5EDP8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

572547:AMICO RS08415
gene id: 572547:AMICO_RS08415
uniprot id: D5EGT4
names: Similarity
messages: Belongs to the peptidase S58 family.

572547:AMICO RS08010
gene id: 572547:AMICO_RS08010
uniprot id: D5EGK3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02775
gene id: 572547:AMICO_RS02775
uniprot id: D5EDR0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

572547:AMICO RS09685
gene id: 572547:AMICO_RS09685
uniprot id: D5EHI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

572547:AMICO RS05990
gene id: 572547:AMICO_RS05990
uniprot id: D5EFG8
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

572547:AMICO RS06005
gene id: 572547:AMICO_RS06005
uniprot id: D5EFH1
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

572547:AMICO RS05370
gene id: 572547:AMICO_RS05370
uniprot id: D5EF42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell inner membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

572547:AMICO RS03425
gene id: 572547:AMICO_RS03425
uniprot id: D5EE35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

572547:AMICO RS04030
gene id: 572547:AMICO_RS04030
uniprot id: D5EEE2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS09375
gene id: 572547:AMICO_RS09375
uniprot id: D5EHC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

572547:AMICO RS02285
gene id: 572547:AMICO_RS02285
uniprot id: D5EDF9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

572547:AMICO RS03675
gene id: 572547:AMICO_RS03675
uniprot id: D5EE81
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

572547:AMICO RS04430
gene id: 572547:AMICO_RS04430
uniprot id: D5EEL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

572547:AMICO RS01145
gene id: 572547:AMICO_RS01145
uniprot id: D5ECU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

572547:AMICO RS09880
gene id: 572547:AMICO_RS09880
uniprot id: D5EEK5
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

572547:AMICO RS08375
gene id: 572547:AMICO_RS08375
uniprot id: D5EGS6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

572547:AMICO RS03410
gene id: 572547:AMICO_RS03410
uniprot id: D5EE32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

572547:AMICO RS05185
gene id: 572547:AMICO_RS05185
uniprot id: D5EF05
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

572547:AMICO RS01965
gene id: 572547:AMICO_RS01965
uniprot id: D5EDA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

572547:AMICO RS06620
gene id: 572547:AMICO_RS06620
uniprot id: D5EFT6
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

572547:AMICO RS07210
gene id: 572547:AMICO_RS07210
uniprot id: D5EG49
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

572547:AMICO RS06970
gene id: 572547:AMICO_RS06970
uniprot id: D5EG01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

572547:AMICO RS01315
gene id: 572547:AMICO_RS01315
uniprot id: D5ECY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS09465
gene id: 572547:AMICO_RS09465
uniprot id: D5EHE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS08025
gene id: 572547:AMICO_RS08025
uniprot id: D5EGK6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

572547:AMICO RS00685
gene id: 572547:AMICO_RS00685
uniprot id: D5ECK8
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

572547:AMICO RS02465
gene id: 572547:AMICO_RS02465
uniprot id: D5EDJ6
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS00020
gene id: 572547:AMICO_RS00020
uniprot id: D5EC71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

572547:AMICO RS07550
gene id: 572547:AMICO_RS07550
uniprot id: D5EGB6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS02410
gene id: 572547:AMICO_RS02410
uniprot id: D5EDI4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

572547:AMICO RS06965
gene id: 572547:AMICO_RS06965
uniprot id: D5EG00
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

572547:AMICO RS07660
gene id: 572547:AMICO_RS07660
uniprot id: D5EGD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

572547:AMICO RS01730
gene id: 572547:AMICO_RS01730
uniprot id: D5ED52
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS08335
gene id: 572547:AMICO_RS08335
uniprot id: D5EGR8
names: Similarity
messages: Belongs to the peptidase C69 family.

572547:AMICO RS02030
gene id: 572547:AMICO_RS02030
uniprot id: D5EDB0
names: Function
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity.

572547:AMICO RS02950
gene id: 572547:AMICO_RS02950
uniprot id: D5EDT9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell inner membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

572547:AMICO RS05360
gene id: 572547:AMICO_RS05360
uniprot id: D5EF40
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

572547:AMICO RS00015
gene id: 572547:AMICO_RS00015
uniprot id: D5EC70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

572547:AMICO RS03650
gene id: 572547:AMICO_RS03650
uniprot id: D5EE76
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

572547:AMICO RS00990
gene id: 572547:AMICO_RS00990
uniprot id: D5ECR9
names: Similarity
messages: Belongs to the carbamate kinase family.

572547:AMICO RS06720
gene id: 572547:AMICO_RS06720
uniprot id: D5EFV5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS00440
gene id: 572547:AMICO_RS00440
uniprot id: D5ECF6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS05465
gene id: 572547:AMICO_RS05465
uniprot id: D5EF61
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

572547:AMICO RS05030
gene id: 572547:AMICO_RS05030
uniprot id: D5EEX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

572547:AMICO RS07035
gene id: 572547:AMICO_RS07035
uniprot id: D5EG14
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS01860
gene id: 572547:AMICO_RS01860
uniprot id: D5ED79
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS02160
gene id: 572547:AMICO_RS02160
uniprot id: D5EDD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

572547:AMICO RS05455
gene id: 572547:AMICO_RS05455
uniprot id: D5EF59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

572547:AMICO RS03490
gene id: 572547:AMICO_RS03490
uniprot id: D5EE47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

572547:AMICO RS01925
gene id: 572547:AMICO_RS01925
uniprot id: D5ED93
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS03960
gene id: 572547:AMICO_RS03960
uniprot id: D5EEC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

572547:AMICO RS02955
gene id: 572547:AMICO_RS02955
uniprot id: D5EDU0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

572547:AMICO RS06195
gene id: 572547:AMICO_RS06195
uniprot id: D5EFK6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

572547:AMICO RS03550
gene id: 572547:AMICO_RS03550
uniprot id: D5EE59
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

572547:AMICO RS01980
gene id: 572547:AMICO_RS01980
uniprot id: D5EDA4
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

572547:AMICO RS08995
gene id: 572547:AMICO_RS08995
uniprot id: D5EH49
names: Similarity
messages: Belongs to the DapA family.

572547:AMICO RS09595
gene id: 572547:AMICO_RS09595
uniprot id: D5EHG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS01690
gene id: 572547:AMICO_RS01690
uniprot id: D5ED44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

572547:AMICO RS05010
gene id: 572547:AMICO_RS05010
uniprot id: D5EEX1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

572547:AMICO RS02510
gene id: 572547:AMICO_RS02510
uniprot id: D5EDK6
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

572547:AMICO RS08345
gene id: 572547:AMICO_RS08345
uniprot id: D5EGS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

572547:AMICO RS07795
gene id: 572547:AMICO_RS07795
uniprot id: D5EGG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

572547:AMICO RS03525
gene id: 572547:AMICO_RS03525
uniprot id: D5EE54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

572547:AMICO RS06905
gene id: 572547:AMICO_RS06905
uniprot id: D5EFY8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

572547:AMICO RS03120
gene id: 572547:AMICO_RS03120
uniprot id: D5EDX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

572547:AMICO RS04620
gene id: 572547:AMICO_RS04620
uniprot id: D5EEQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

572547:AMICO RS02970
gene id: 572547:AMICO_RS02970
uniprot id: D5EDU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

572547:AMICO RS05435
gene id: 572547:AMICO_RS05435
uniprot id: D5EF55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

572547:AMICO RS03110
gene id: 572547:AMICO_RS03110
uniprot id: D5EDX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

572547:AMICO RS03655
gene id: 572547:AMICO_RS03655
uniprot id: D5EE77
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

572547:AMICO RS00550
gene id: 572547:AMICO_RS00550
uniprot id: D5ECI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

572547:AMICO RS07260
gene id: 572547:AMICO_RS07260
uniprot id: D5EG59
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

572547:AMICO RS03055
gene id: 572547:AMICO_RS03055
uniprot id: D5EDW0
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

572547:AMICO RS04425
gene id: 572547:AMICO_RS04425
uniprot id: D5EEL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

572547:AMICO RS06010
gene id: 572547:AMICO_RS06010
uniprot id: D5EFH2
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

572547:AMICO RS05985
gene id: 572547:AMICO_RS05985
uniprot id: D5EFG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

572547:AMICO RS01140
gene id: 572547:AMICO_RS01140
uniprot id: D5ECU8
names: Similarity
messages: Belongs to the disproportionating enzyme family.

572547:AMICO RS09025
gene id: 572547:AMICO_RS09025
uniprot id: D5EH55
names: Subcellular Location Annotation
messages: Cytoplasm

572547:AMICO RS09635
gene id: 572547:AMICO_RS09635
uniprot id: D5EHH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

572547:AMICO RS01030
gene id: 572547:AMICO_RS01030
uniprot id: D5ECS6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

572547:AMICO RS00895
gene id: 572547:AMICO_RS00895
uniprot id: D5ECQ0
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

572547:AMICO RS00560
gene id: 572547:AMICO_RS00560
uniprot id: D5ECI3
names: Similarity
messages: Belongs to the RutC family.

572547:AMICO RS07025
gene id: 572547:AMICO_RS07025
uniprot id: D5EG12
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

572547:AMICO RS03035
gene id: 572547:AMICO_RS03035
uniprot id: D5EDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

572547:AMICO RS06875
gene id: 572547:AMICO_RS06875
uniprot id: D5EFY3
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS05140
gene id: 572547:AMICO_RS05140
uniprot id: D5EEZ7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

572547:AMICO RS07800
gene id: 572547:AMICO_RS07800
uniprot id: D5EGG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

572547:AMICO RS09755
gene id: 572547:AMICO_RS09755
uniprot id: D5ECX7
names: Similarity
messages: Belongs to the peptidase A24 family.

572547:AMICO RS07900
gene id: 572547:AMICO_RS07900
uniprot id: D5EGI2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

572547:AMICO RS06235
gene id: 572547:AMICO_RS06235
uniprot id: D5EFL3
names: Similarity
messages: Belongs to the arginine deiminase family.

572547:AMICO RS02475
gene id: 572547:AMICO_RS02475
uniprot id: D5EDJ8
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

572547:AMICO RS08820
gene id: 572547:AMICO_RS08820
uniprot id: D5EH15
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

572547:AMICO RS03170
gene id: 572547:AMICO_RS03170
uniprot id: D5EDY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

572547:AMICO RS02640
gene id: 572547:AMICO_RS02640
uniprot id: D5EDN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

572547:AMICO RS06020
gene id: 572547:AMICO_RS06020
uniprot id: D5EFH4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

572547:AMICO RS09305
gene id: 572547:AMICO_RS09305
uniprot id: D5EHA9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

572547:AMICO RS05105
gene id: 572547:AMICO_RS05105
uniprot id: D5EEZ0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

572547:AMICO RS03330
gene id: 572547:AMICO_RS03330
uniprot id: D5EE15
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS00375
gene id: 572547:AMICO_RS00375
uniprot id: D5ECE3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

572547:AMICO RS04290
gene id: 572547:AMICO_RS04290
uniprot id: D5EEJ1
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

572547:AMICO RS01450
gene id: 572547:AMICO_RS01450
uniprot id: D5ED07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

572547:AMICO RS09245
gene id: 572547:AMICO_RS09245
uniprot id: D5EH97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

572547:AMICO RS01100
gene id: 572547:AMICO_RS01100
uniprot id: D5ECU0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

572547:AMICO RS00805
gene id: 572547:AMICO_RS00805
uniprot id: D5ECN2
names: Similarity
messages: Belongs to the AOR/FOR family.

572547:AMICO RS03825
gene id: 572547:AMICO_RS03825
uniprot id: D5EEB0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

572547:AMICO RS06565
gene id: 572547:AMICO_RS06565
uniprot id: D5EFS6
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS04970
gene id: 572547:AMICO_RS04970
uniprot id: D5EEW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

572547:AMICO RS04660
gene id: 572547:AMICO_RS04660
uniprot id: D5EER1
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

572547:AMICO RS06830
gene id: 572547:AMICO_RS06830
uniprot id: D5EFX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M15D family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.

572547:AMICO RS05045
gene id: 572547:AMICO_RS05045
uniprot id: D5EEX8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

572547:AMICO RS04345
gene id: 572547:AMICO_RS04345
uniprot id: D5EEK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

572547:AMICO RS07055
gene id: 572547:AMICO_RS07055
uniprot id: D5EG18
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

572547:AMICO RS03665
gene id: 572547:AMICO_RS03665
uniprot id: D5EE79
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

572547:AMICO RS03465
gene id: 572547:AMICO_RS03465
uniprot id: D5EE43
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

572547:AMICO RS04235
gene id: 572547:AMICO_RS04235
uniprot id: D5EEI2
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

572547:AMICO RS01495
gene id: 572547:AMICO_RS01495
uniprot id: D5ED16
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

572547:AMICO RS08090
gene id: 572547:AMICO_RS08090
uniprot id: D5EGL9
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

572547:AMICO RS00870
gene id: 572547:AMICO_RS00870
uniprot id: D5ECP5
names: Similarity
messages: Belongs to the peptidase C69 family.

572547:AMICO RS06355
gene id: 572547:AMICO_RS06355
uniprot id: D5EFN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

572547:AMICO RS00720
gene id: 572547:AMICO_RS00720
uniprot id: D5ECL5
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

572547:AMICO RS06050
gene id: 572547:AMICO_RS06050
uniprot id: D5EFI0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

572547:AMICO RS08500
gene id: 572547:AMICO_RS08500
uniprot id: D5EGV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS03770
gene id: 572547:AMICO_RS03770
uniprot id: D5EE99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

572547:AMICO RS07350
gene id: 572547:AMICO_RS07350
uniprot id: D5EG77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

572547:AMICO RS02930
gene id: 572547:AMICO_RS02930
uniprot id: D5EDT5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

572547:AMICO RS01985
gene id: 572547:AMICO_RS01985
uniprot id: D5EDA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS00555
gene id: 572547:AMICO_RS00555
uniprot id: D5ECI2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

572547:AMICO RS06530
gene id: 572547:AMICO_RS06530
uniprot id: D5EFS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

572547:AMICO RS00435
gene id: 572547:AMICO_RS00435
uniprot id: D5ECF5
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS07245
gene id: 572547:AMICO_RS07245
uniprot id: D5EG56
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS03970
gene id: 572547:AMICO_RS03970
uniprot id: D5EED1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

572547:AMICO RS01420
gene id: 572547:AMICO_RS01420
uniprot id: D5ED01
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

572547:AMICO RS08720
gene id: 572547:AMICO_RS08720
uniprot id: D5EGZ6
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS04365
gene id: 572547:AMICO_RS04365
uniprot id: D5EEK6
names: Similarity
messages: Belongs to the peptidase U62 family.

572547:AMICO RS01430
gene id: 572547:AMICO_RS01430
uniprot id: D5ED03
names: Similarity
messages: Belongs to the threonine aldolase family.

572547:AMICO RS00630
gene id: 572547:AMICO_RS00630
uniprot id: D5ECJ7
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02360
gene id: 572547:AMICO_RS02360
uniprot id: D5EDH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS03225
gene id: 572547:AMICO_RS03225
uniprot id: D5EDZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

572547:AMICO RS07270
gene id: 572547:AMICO_RS07270
uniprot id: D5EG61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

572547:AMICO RS06160
gene id: 572547:AMICO_RS06160
uniprot id: D5EFK0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

572547:AMICO RS03175
gene id: 572547:AMICO_RS03175
uniprot id: D5EDY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

572547:AMICO RS00035
gene id: 572547:AMICO_RS00035
uniprot id: D5EC75
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS01800
gene id: 572547:AMICO_RS01800
uniprot id: D5ED66
names: Similarity
messages: Belongs to the CdaR family.

572547:AMICO RS01590
gene id: 572547:AMICO_RS01590
uniprot id: D5ED30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

572547:AMICO RS03295
gene id: 572547:AMICO_RS03295
uniprot id: D5EE08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

572547:AMICO RS06945
gene id: 572547:AMICO_RS06945
uniprot id: D5EFZ6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

572547:AMICO RS01885
gene id: 572547:AMICO_RS01885
uniprot id: D5ED85
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

572547:AMICO RS03635
gene id: 572547:AMICO_RS03635
uniprot id: D5EE73
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

572547:AMICO RS02925
gene id: 572547:AMICO_RS02925
uniprot id: D5EDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

572547:AMICO RS01945
gene id: 572547:AMICO_RS01945
uniprot id: D5ED97
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS04340
gene id: 572547:AMICO_RS04340
uniprot id: D5EEK1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

572547:AMICO RS01565
gene id: 572547:AMICO_RS01565
uniprot id: D5ED25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

572547:AMICO RS07570
gene id: 572547:AMICO_RS07570
uniprot id: D5EGC0
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS08740
gene id: 572547:AMICO_RS08740
uniprot id: D5EGZ9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

572547:AMICO RS09065
gene id: 572547:AMICO_RS09065
uniprot id: D5EH63
names: Subcellular Location Annotation
messages: Membrane

572547:AMICO RS02325
gene id: 572547:AMICO_RS02325
uniprot id: D5EDG8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

572547:AMICO RS01185
gene id: 572547:AMICO_RS01185
uniprot id: D5ECV7
names: Similarity
messages: Belongs to the BMP lipoprotein family.

572547:AMICO RS00205
gene id: 572547:AMICO_RS00205
uniprot id: D5ECA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

572547:AMICO RS01665
gene id: 572547:AMICO_RS01665
uniprot id: D5ED38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

572547:AMICO RS00350
gene id: 572547:AMICO_RS00350
uniprot id: D5ECD7
names: Similarity
messages: Belongs to the threonine synthase family.

572547:AMICO RS08160
gene id: 572547:AMICO_RS08160
uniprot id: D5EGN3
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

572547:AMICO RS03850
gene id: 572547:AMICO_RS03850
uniprot id: D5EEB5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

572547:AMICO RS02805
gene id: 572547:AMICO_RS02805
uniprot id: D5EDR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell inner membrane
messages: Probably interacts with PlsX.

572547:AMICO RS07190
gene id: 572547:AMICO_RS07190
uniprot id: D5EG45
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

572547:AMICO RS05310
gene id: 572547:AMICO_RS05310
uniprot id: D5EF30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

572547:AMICO RS02450
gene id: 572547:AMICO_RS02450
uniprot id: D5EDJ3
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

572547:AMICO RS01710
gene id: 572547:AMICO_RS01710
uniprot id: D5ED48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

572547:AMICO RS02810
gene id: 572547:AMICO_RS02810
uniprot id: D5EDR6
names: Similarity
messages: Belongs to the CtsR family.

572547:AMICO RS03190
gene id: 572547:AMICO_RS03190
uniprot id: D5EDY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

572547:AMICO RS06420
gene id: 572547:AMICO_RS06420
uniprot id: D5EFP8
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

572547:AMICO RS06105
gene id: 572547:AMICO_RS06105
uniprot id: D5EFI9
names: Similarity
messages: Belongs to the GSP E family.

572547:AMICO RS04505
gene id: 572547:AMICO_RS04505
uniprot id: D5ECY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

572547:AMICO RS03800
gene id: 572547:AMICO_RS03800
uniprot id: D5EEA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

572547:AMICO RS07280
gene id: 572547:AMICO_RS07280
uniprot id: D5EG63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

572547:AMICO RS01455
gene id: 572547:AMICO_RS01455
uniprot id: D5ED08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

572547:AMICO RS05970
gene id: 572547:AMICO_RS05970
uniprot id: D5EFG4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

572547:AMICO RS05935
gene id: 572547:AMICO_RS05935
uniprot id: D5EFF7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

572547:AMICO RS02690
gene id: 572547:AMICO_RS02690
uniprot id: D5EDP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

572547:AMICO RS04555
gene id: 572547:AMICO_RS04555
uniprot id: D5EEP2
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

572547:AMICO RS05905
gene id: 572547:AMICO_RS05905
uniprot id: D5EFF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

572547:AMICO RS04225
gene id: 572547:AMICO_RS04225
uniprot id: D5EEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

572547:AMICO RS07615
gene id: 572547:AMICO_RS07615
uniprot id: D5EGC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

572547:AMICO RS05020
gene id: 572547:AMICO_RS05020
uniprot id: D5EEX3
names: Similarity
messages: Belongs to the ycf81 family.

572547:AMICO RS03760
gene id: 572547:AMICO_RS03760
uniprot id: D5EE97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

572547:AMICO RS01435
gene id: 572547:AMICO_RS01435
uniprot id: D5ED04
names: Similarity
messages: Belongs to the peptidase U62 family.

572547:AMICO RS07005
gene id: 572547:AMICO_RS07005
uniprot id: D5EG08
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

572547:AMICO RS07835
gene id: 572547:AMICO_RS07835
uniprot id: D5EGG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

572547:AMICO RS04090
gene id: 572547:AMICO_RS04090
uniprot id: D5EEF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

572547:AMICO RS00705
gene id: 572547:AMICO_RS00705
uniprot id: D5ECL2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

572547:AMICO RS02985
gene id: 572547:AMICO_RS02985
uniprot id: D5EDU6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

572547:AMICO RS02790
gene id: 572547:AMICO_RS02790
uniprot id: D5EDR2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

572547:AMICO RS09300
gene id: 572547:AMICO_RS09300
uniprot id: D5EHA8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

572547:AMICO RS09075
gene id: 572547:AMICO_RS09075
uniprot id: D5EH65
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

572547:AMICO RS02020
gene id: 572547:AMICO_RS02020
uniprot id: D5EDA8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

572547:AMICO RS03185
gene id: 572547:AMICO_RS03185
uniprot id: D5EDY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

572547:AMICO RS03935
gene id: 572547:AMICO_RS03935
uniprot id: D5EEC7
names: Similarity
messages: Belongs to the bacterial secretin family.

572547:AMICO RS04995
gene id: 572547:AMICO_RS04995
uniprot id: D5EEW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

572547:AMICO RS03250
gene id: 572547:AMICO_RS03250
uniprot id: D5EDZ8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

572547:AMICO RS04250
gene id: 572547:AMICO_RS04250
uniprot id: D5EEI5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.