564:LA347 RS12740
gene id: 564:LA347_RS12740
uniprot id: A0A2S7SCP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS07130
gene id: 564:LA347_RS07130
uniprot id: A0A7L6S993
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

564:LA347 RS07645
gene id: 564:LA347_RS07645
uniprot id: A0A7K4I1F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

564:LA347 RS13935
gene id: 564:LA347_RS13935
uniprot id: A0A2S7SJ31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

564:LA347 RS09220
gene id: 564:LA347_RS09220
uniprot id: A0A7K4HZG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

564:LA347 RS18535
gene id: 564:LA347_RS18535
uniprot id: A0A7L6S023
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS17575
gene id: 564:LA347_RS17575
uniprot id: A0A2S7SE41
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

564:LA347 RS04785
gene id: 564:LA347_RS04785
uniprot id: A0A7K4I253
names: Similarity
messages: Belongs to the UPF0502 family.

564:LA347 RS17650
gene id: 564:LA347_RS17650
uniprot id: A0A2S7SEC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. WecA subfamily.
messages: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
messages: Cell inner membrane
messages: Membrane

564:LA347 RS01280
gene id: 564:LA347_RS01280
uniprot id: A0A2S7SN36
names: Similarity
messages: Belongs to the P(II) protein family.

564:LA347 RS08485
gene id: 564:LA347_RS08485
uniprot id: A0A7K4HZW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Interacts with the TusBCD complex. Interacts with MnmA.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD.

564:LA347 RS10480
gene id: 564:LA347_RS10480
uniprot id: A0A7K4HYR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamC family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

564:LA347 RS01185
gene id: 564:LA347_RS01185
uniprot id: A0A2S7SN18
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

564:LA347 RS21255
gene id: 564:LA347_RS21255
uniprot id: A0A7K4HU71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

564:LA347 RS18350
gene id: 564:LA347_RS18350
uniprot id: A0A7W3EM14
names: Similarity
messages: Belongs to the FGGY kinase family.

564:LA347 RS20840
gene id: 564:LA347_RS20840
uniprot id: A0A7K4HTB4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
messages: Homohexamer; trimer of dimers.

564:LA347 RS11200
gene id: 564:LA347_RS11200
uniprot id: A0A2S7SMZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

564:LA347 RS08545
gene id: 564:LA347_RS08545
uniprot id: A0A7K4HZV0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer and homodimer.
messages: Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
messages: The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.
messages: With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.

564:LA347 RS17795
gene id: 564:LA347_RS17795
uniprot id: A0A2S7SEA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS01390
gene id: 564:LA347_RS01390
uniprot id: A0A2S7SN57
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

564:LA347 RS15995
gene id: 564:LA347_RS15995
uniprot id: A0A7W3EMP8
names: Similarity
messages: Belongs to the malate synthase family.

564:LA347 RS01205
gene id: 564:LA347_RS01205
uniprot id: A0A7L6RY42
names: Similarity
messages: Belongs to the BolA/IbaG family.

564:LA347 RS16855
gene id: 564:LA347_RS16855
uniprot id: A0A7L6VCX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

564:LA347 RS13415
gene id: 564:LA347_RS13415
uniprot id: A0A7K4HYD6
names: Function
messages: Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.

564:LA347 RS13085
gene id: 564:LA347_RS13085
uniprot id: A0A2S7SJU4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

564:LA347 RS12585
gene id: 564:LA347_RS12585
uniprot id: A0A7K4HXS7
names: Function
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

564:LA347 RS13980
gene id: 564:LA347_RS13980
uniprot id: A0A7T4TFW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

564:LA347 RS16445
gene id: 564:LA347_RS16445
uniprot id: A0A2S7SHW4
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: By heat shock.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

564:LA347 RS13115
gene id: 564:LA347_RS13115
uniprot id: A0A7K4HYJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.

564:LA347 RS05740
gene id: 564:LA347_RS05740
uniprot id: A0A7L6S7L6
names: Similarity
messages: Belongs to the UPF0509 family.

564:LA347 RS16770
gene id: 564:LA347_RS16770
uniprot id: A0A7K4HVK1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

564:LA347 RS04705
gene id: 564:LA347_RS04705
uniprot id: A0A7L6VRH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OpgD/OpgG family.
messages: Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
messages: Periplasm

564:LA347 RS16655
gene id: 564:LA347_RS16655
uniprot id: A0A2S7SHS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

564:LA347 RS00985
gene id: 564:LA347_RS00985
uniprot id: A0A7K4HRY8
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

564:LA347 RS19110
gene id: 564:LA347_RS19110
uniprot id: A0A7L6W596
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS11985
gene id: 564:LA347_RS11985
uniprot id: A0A564TYZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

564:LA347 RS11760
gene id: 564:LA347_RS11760
uniprot id: A0A8E4IJA8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS12160
gene id: 564:LA347_RS12160
uniprot id: A0A2S7SGT9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

564:LA347 RS00280
gene id: 564:LA347_RS00280
uniprot id: A0A7L6RY58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

564:LA347 RS13970
gene id: 564:LA347_RS13970
uniprot id: A0A564UMA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

564:LA347 RS09625
gene id: 564:LA347_RS09625
uniprot id: A0A7K4HZA3
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS13885
gene id: 564:LA347_RS13885
uniprot id: A0A7K4HXT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

564:LA347 RS19660
gene id: 564:LA347_RS19660
uniprot id: A0A2S7SDP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

564:LA347 RS17375
gene id: 564:LA347_RS17375
uniprot id: A0A7L6SDI4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS09800
gene id: 564:LA347_RS09800
uniprot id: A0A7K4I0B7
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Specifically methylates the 50S ribosomal protein L3 on 'Gln-150'.

564:LA347 RS09400
gene id: 564:LA347_RS09400
uniprot id: A0A7L6RU55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
messages: Cell membrane

564:LA347 RS21185
gene id: 564:LA347_RS21185
uniprot id: A0A7K4HT36
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

564:LA347 RS13290
gene id: 564:LA347_RS13290
uniprot id: A0A7K4HXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

564:LA347 RS09040
gene id: 564:LA347_RS09040
uniprot id: A0A7K4HZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
messages: Cell membrane

564:LA347 RS21745
gene id: 564:LA347_RS21745
uniprot id: A0A7K4HTU6
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

564:LA347 RS02655
gene id: 564:LA347_RS02655
uniprot id: A0A7K4I340
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

564:LA347 RS16930
gene id: 564:LA347_RS16930
uniprot id: A0A2S7SHM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

564:LA347 RS13550
gene id: 564:LA347_RS13550
uniprot id: A0A7K4HX89
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

564:LA347 RS18225
gene id: 564:LA347_RS18225
uniprot id: A0A7K4HVR8
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

564:LA347 RS11885
gene id: 564:LA347_RS11885
uniprot id: A0A7K4HZ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AlaE exporter family.
messages: Cell inner membrane
messages: Exports L-alanine.

564:LA347 RS06605
gene id: 564:LA347_RS06605
uniprot id: A0A7K4I1A2
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: Membrane
messages: The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.

564:LA347 RS16740
gene id: 564:LA347_RS16740
uniprot id: A0A7K4HVJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

564:LA347 RS17225
gene id: 564:LA347_RS17225
uniprot id: A0A7K4HVA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

564:LA347 RS00880
gene id: 564:LA347_RS00880
uniprot id: A0A8E4N7A0
names: Function
names: Similarity
messages: Belongs to the IprA family.
messages: Involved in oxidative stress resistance.

564:LA347 RS13145
gene id: 564:LA347_RS13145
uniprot id: A0A7K4HXG5
names: Similarity
messages: Belongs to the UPF0231 family.

564:LA347 RS00210
gene id: 564:LA347_RS00210
uniprot id: A0A7K4HT51
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

564:LA347 RS02010
gene id: 564:LA347_RS02010
uniprot id: A0A7K4I3M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS16875
gene id: 564:LA347_RS16875
uniprot id: A0A2S7SHN7
names: Similarity
messages: Belongs to the UPF0758 family. YicR subfamily.

564:LA347 RS13680
gene id: 564:LA347_RS13680
uniprot id: A0A7K4HY87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OadG family.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

564:LA347 RS13140
gene id: 564:LA347_RS13140
uniprot id: A0A7K4HXG2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

564:LA347 RS12860
gene id: 564:LA347_RS12860
uniprot id: A0A7K4HXX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

564:LA347 RS12045
gene id: 564:LA347_RS12045
uniprot id: A0A2S7SGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

564:LA347 RS04920
gene id: 564:LA347_RS04920
uniprot id: A0A7K4I2A2
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

564:LA347 RS17495
gene id: 564:LA347_RS17495
uniprot id: A0A2S7SBR7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

564:LA347 RS15080
gene id: 564:LA347_RS15080
uniprot id: A0A7K4HX97
names: Function
names: Induction
names: Similarity
messages: Belongs to the L-ribulose-5-phosphate 3-epimerase family.
messages: Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
messages: Induced by L-ascorbate. Repressed by UlaR.

564:LA347 RS13700
gene id: 564:LA347_RS13700
uniprot id: A0A7W3I1Y9
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS07175
gene id: 564:LA347_RS07175
uniprot id: A0A7K4I1T2
names: Similarity
messages: Belongs to the pyruvate kinase family.

564:LA347 RS06065
gene id: 564:LA347_RS06065
uniprot id: A0A7K4I2H7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

564:LA347 RS08130
gene id: 564:LA347_RS08130
uniprot id: A0A7K4I027
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

564:LA347 RS02565
gene id: 564:LA347_RS02565
uniprot id: A0A7W3EDC8
names: Similarity
messages: Belongs to the YbiA family.

564:LA347 RS13735
gene id: 564:LA347_RS13735
uniprot id: A0A7W3END3
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

564:LA347 RS08705
gene id: 564:LA347_RS08705
uniprot id: A0A7K4I011
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

564:LA347 RS09030
gene id: 564:LA347_RS09030
uniprot id: A0A7K4HZU4
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

564:LA347 RS01770
gene id: 564:LA347_RS01770
uniprot id: A0A7B5PEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

564:LA347 RS20025
gene id: 564:LA347_RS20025
uniprot id: A0A2S7SGX9
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

564:LA347 RS12905
gene id: 564:LA347_RS12905
uniprot id: A0A7K4HXL8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

564:LA347 RS13335
gene id: 564:LA347_RS13335
uniprot id: A0A7K4HXC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

564:LA347 RS08680
gene id: 564:LA347_RS08680
uniprot id: A0A7K4I0T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukE family.
messages: Interacts, and probably forms a ternary complex, with MukF and MukB. The complex formation is stimulated by calcium or magnesium.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
messages: nucleoid

564:LA347 RS19880
gene id: 564:LA347_RS19880
uniprot id: A0A7L6VMU7
names: Similarity
messages: Belongs to the Smg family.

564:LA347 RS15345
gene id: 564:LA347_RS15345
uniprot id: A0A2S7SID7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: Is beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC. Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety would extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. The hydroxylation of the C5 position on Lys-34 would allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

564:LA347 RS14170
gene id: 564:LA347_RS14170
uniprot id: A0A7T4NGT6
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS01250
gene id: 564:LA347_RS01250
uniprot id: A0A7W3HVF0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

564:LA347 RS17700
gene id: 564:LA347_RS17700
uniprot id: A0A7W3HZU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzyE family.
messages: Cell inner membrane
messages: Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

564:LA347 RS02000
gene id: 564:LA347_RS02000
uniprot id: A0A7K4I393
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SeqA family.
messages: Cytoplasm
messages: Homodimer. Polymerizes to form helical filaments.
messages: Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

564:LA347 RS20935
gene id: 564:LA347_RS20935
uniprot id: A0A7W3EF39
names: Similarity
messages: Belongs to the UPF0597 family.

564:LA347 RS02725
gene id: 564:LA347_RS02725
uniprot id: A0A7K4I2X5
names: Similarity
messages: To H.influenzae HI_0842.

564:LA347 RS19340
gene id: 564:LA347_RS19340
uniprot id: A0A2S7SE10
names: Function
names: Similarity
messages: Belongs to the FeoC family.
messages: May function as a transcriptional regulator that controls feoABC expression.

564:LA347 RS15300
gene id: 564:LA347_RS15300
uniprot id: A0A2S7SIL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

564:LA347 RS21750
gene id: 564:LA347_RS21750
uniprot id: A0A7L6RYX2
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

564:LA347 RS05840
gene id: 564:LA347_RS05840
uniprot id: A0A7K4I1G3
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

564:LA347 RS13660
gene id: 564:LA347_RS13660
uniprot id: A0A7K4HXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.
messages: Represents a citryl-ACP lyase.

564:LA347 RS10525
gene id: 564:LA347_RS10525
uniprot id: A0A4Y5RKD4
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS17990
gene id: 564:LA347_RS17990
uniprot id: A0A7K4HUW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
messages: Cytoplasm

564:LA347 RS16230
gene id: 564:LA347_RS16230
uniprot id: A0A7K4HWX3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

564:LA347 RS04930
gene id: 564:LA347_RS04930
uniprot id: A0A7K4I348
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

564:LA347 RS10455
gene id: 564:LA347_RS10455
uniprot id: A0A7K4HYS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0370 family.
messages: Cell membrane

564:LA347 RS12845
gene id: 564:LA347_RS12845
uniprot id: A0A7K4HXN5
names: Similarity
messages: Belongs to the skp family.

564:LA347 RS08740
gene id: 564:LA347_RS08740
uniprot id: A0A7K4HZQ4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Required for translation of most natural mRNAs except for leaderless mRNA. Binds mRNA upstream of the Shine-Dalgarno (SD) sequence and helps it bind to the 30S ribosomal subunit; acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated. Unwinds dsRNA by binding to transiently formed ssRNA regions; binds about 10 nucleotides. Has a preference for polypyrimidine tracts. Negatively autoregulates its own translation.

564:LA347 RS01385
gene id: 564:LA347_RS01385
uniprot id: A0A2S7SN54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

564:LA347 RS00025
gene id: 564:LA347_RS00025
uniprot id: A0A7K4HSK6
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family.
messages: Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.

564:LA347 RS03590
gene id: 564:LA347_RS03590
uniprot id: A0A7K4I2F9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
messages: Feedback inhibited by histidine.

564:LA347 RS04450
gene id: 564:LA347_RS04450
uniprot id: A0A7L6RWV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

564:LA347 RS02540
gene id: 564:LA347_RS02540
uniprot id: A0A564UX12
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS06680
gene id: 564:LA347_RS06680
uniprot id: A0A7L6VVU1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS21660
gene id: 564:LA347_RS21660
uniprot id: A0A2S7SEN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
messages: Monomer.

564:LA347 RS16870
gene id: 564:LA347_RS16870
uniprot id: A0A2S7SI36
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

564:LA347 RS05480
gene id: 564:LA347_RS05480
uniprot id: A0A7K4I1Q0
names: Caution
names: Similarity
messages: Belongs to the NTE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS18305
gene id: 564:LA347_RS18305
uniprot id: A0A7L6VQM9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

564:LA347 RS20120
gene id: 564:LA347_RS20120
uniprot id: A0A7K4HUQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

564:LA347 RS08160
gene id: 564:LA347_RS08160
uniprot id: A0A7K4I037
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

564:LA347 RS10670
gene id: 564:LA347_RS10670
uniprot id: A0A7K4HYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

564:LA347 RS17685
gene id: 564:LA347_RS17685
uniprot id: A0A7L6VPN0
names: Function
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.
messages: Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.

564:LA347 RS21440
gene id: 564:LA347_RS21440
uniprot id: A0A7K4HSZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

564:LA347 RS08170
gene id: 564:LA347_RS08170
uniprot id: A0A7K4I137
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

564:LA347 RS19350
gene id: 564:LA347_RS19350
uniprot id: A0A7K4HUR8
names: Similarity
messages: Belongs to the FeoA family.

564:LA347 RS19675
gene id: 564:LA347_RS19675
uniprot id: A0A7K4HU58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

564:LA347 RS11730
gene id: 564:LA347_RS11730
uniprot id: A0A7L6RSH7
names: Similarity
messages: Belongs to the UPF0145 family.

564:LA347 RS19315
gene id: 564:LA347_RS19315
uniprot id: A0A2S7SFW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

564:LA347 RS00910
gene id: 564:LA347_RS00910
uniprot id: A0A7K4HS52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

564:LA347 RS16865
gene id: 564:LA347_RS16865
uniprot id: A0A2S7SHN3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

564:LA347 RS00780
gene id: 564:LA347_RS00780
uniprot id: A0A7K4HS30
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS15190
gene id: 564:LA347_RS15190
uniprot id: A0A2S7SJ66
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins.

564:LA347 RS01700
gene id: 564:LA347_RS01700
uniprot id: A0A7B5TG20
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

564:LA347 RS03265
gene id: 564:LA347_RS03265
uniprot id: A0A7K4I2S1
names: Subcellular Location Annotation
messages: Cell inner membrane

564:LA347 RS17015
gene id: 564:LA347_RS17015
uniprot id: A0A7K4HVD4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

564:LA347 RS00990
gene id: 564:LA347_RS00990
uniprot id: A0A7K4HRY7
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

564:LA347 RS20820
gene id: 564:LA347_RS20820
uniprot id: A0A7K4HUC5
names: Function
names: Similarity
messages: Belongs to the non-flavoprotein flavin reductase family. HpaC subfamily.
messages: Catalyzes the reduction of free flavins (FMN, FAD and riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the large HpaB component or to other electron acceptors such as cytochrome c and Fe(3+) ion.

564:LA347 RS14670
gene id: 564:LA347_RS14670
uniprot id: A0A7K4HXS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

564:LA347 RS13320
gene id: 564:LA347_RS13320
uniprot id: A0A2S7SK14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

564:LA347 RS17350
gene id: 564:LA347_RS17350
uniprot id: A0A7K4HW88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.

564:LA347 RS15310
gene id: 564:LA347_RS15310
uniprot id: A0A2S7SJ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdC family.
messages: Cell membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

564:LA347 RS10565
gene id: 564:LA347_RS10565
uniprot id: A0A8E4ILT6
names: Similarity
messages: Belongs to the ArsC family.

564:LA347 RS04135
gene id: 564:LA347_RS04135
uniprot id: A0A7K4I285
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS07635
gene id: 564:LA347_RS07635
uniprot id: A0A7K4I1G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

564:LA347 RS18655
gene id: 564:LA347_RS18655
uniprot id: A0A7K4HVJ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

564:LA347 RS06370
gene id: 564:LA347_RS06370
uniprot id: A0A7K4I190
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

564:LA347 RS03635
gene id: 564:LA347_RS03635
uniprot id: A0A7K4I2C4
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

564:LA347 RS08135
gene id: 564:LA347_RS08135
uniprot id: A0A7K4I034
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

564:LA347 RS08390
gene id: 564:LA347_RS08390
uniprot id: A0A7K4HZY4
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

564:LA347 RS09445
gene id: 564:LA347_RS09445
uniprot id: A0A2S7SLV7
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS07330
gene id: 564:LA347_RS07330
uniprot id: A0A7K4I1M0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS16510
gene id: 564:LA347_RS16510
uniprot id: A0A7K4HW01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

564:LA347 RS12550
gene id: 564:LA347_RS12550
uniprot id: A0A7K4HY21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS19080
gene id: 564:LA347_RS19080
uniprot id: A0A7K4HV92
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS15180
gene id: 564:LA347_RS15180
uniprot id: A0A2S7SIN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

564:LA347 RS18440
gene id: 564:LA347_RS18440
uniprot id: A0A7K4HVC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

564:LA347 RS17645
gene id: 564:LA347_RS17645
uniprot id: A0A2S7SB31
names: Similarity
messages: Belongs to the class-A beta-lactamase family.

564:LA347 RS07820
gene id: 564:LA347_RS07820
uniprot id: A0A7K4I089
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ProQ family.
messages: Cytoplasm
messages: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.

564:LA347 RS19465
gene id: 564:LA347_RS19465
uniprot id: A0A7K4HTZ6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

564:LA347 RS05390
gene id: 564:LA347_RS05390
uniprot id: A0A7K4I2W1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS15610
gene id: 564:LA347_RS15610
uniprot id: A0A791AMQ2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

564:LA347 RS17115
gene id: 564:LA347_RS17115
uniprot id: A0A7K4HVB6
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS01175
gene id: 564:LA347_RS01175
uniprot id: A0A2S7SND8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

564:LA347 RS19890
gene id: 564:LA347_RS19890
uniprot id: A0A7K4I567
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

564:LA347 RS17410
gene id: 564:LA347_RS17410
uniprot id: A0A2S7SBM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

564:LA347 RS20500
gene id: 564:LA347_RS20500
uniprot id: A0A7L6ZUR2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS07080
gene id: 564:LA347_RS07080
uniprot id: A0A564UQW8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

564:LA347 RS04880
gene id: 564:LA347_RS04880
uniprot id: A0A7K4I360
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

564:LA347 RS18890
gene id: 564:LA347_RS18890
uniprot id: A0A7K4HVF5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Homotetramer.
messages: Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.

564:LA347 RS11225
gene id: 564:LA347_RS11225
uniprot id: A0A7W3I0W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

564:LA347 RS14410
gene id: 564:LA347_RS14410
uniprot id: A0A7K4HWX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Has been proposed to be a redox modulator.
messages: Membrane

564:LA347 RS04490
gene id: 564:LA347_RS04490
uniprot id: A0A7L6VZM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

564:LA347 RS07190
gene id: 564:LA347_RS07190
uniprot id: A0A7L6VHX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SufE family.
messages: Cytoplasm
messages: Homodimer. Interacts with SufS.
messages: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.

564:LA347 RS19735
gene id: 564:LA347_RS19735
uniprot id: A0A2S7SDS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

564:LA347 RS02290
gene id: 564:LA347_RS02290
uniprot id: A0A7L6S9Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

564:LA347 RS04905
gene id: 564:LA347_RS04905
uniprot id: A0A7L6RW49
names: Similarity
messages: Belongs to the fabD family.

564:LA347 RS13590
gene id: 564:LA347_RS13590
uniprot id: A0A7K4HX78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
messages: Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
messages: Cell membrane
messages: Homotrimer.
messages: Membrane

564:LA347 RS03040
gene id: 564:LA347_RS03040
uniprot id: A0A2S7SPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0387 family.
messages: Cell membrane

564:LA347 RS08810
gene id: 564:LA347_RS08810
uniprot id: A0A7K4HZY9
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

564:LA347 RS05890
gene id: 564:LA347_RS05890
uniprot id: A0A7K4I1F3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

564:LA347 RS14990
gene id: 564:LA347_RS14990
uniprot id: A0A7K4HWI7
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS02390
gene id: 564:LA347_RS02390
uniprot id: A0A7K4I327
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
messages: Belongs to the AcrZ family.
messages: Cell membrane
messages: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.

564:LA347 RS03605
gene id: 564:LA347_RS03605
uniprot id: A0A7K4I2Q0
names: Similarity
messages: Belongs to the YoeB family.

564:LA347 RS19480
gene id: 564:LA347_RS19480
uniprot id: A0A7K4HU03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS16090
gene id: 564:LA347_RS16090
uniprot id: A0A7W3HXA5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Homodimer.

564:LA347 RS17210
gene id: 564:LA347_RS17210
uniprot id: A0A7K4HV97
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

564:LA347 RS13220
gene id: 564:LA347_RS13220
uniprot id: A0A7L6VUJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

564:LA347 RS06315
gene id: 564:LA347_RS06315
uniprot id: A0A7W3HX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
messages: Membrane

564:LA347 RS02735
gene id: 564:LA347_RS02735
uniprot id: A0A7K4I3U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

564:LA347 RS17545
gene id: 564:LA347_RS17545
uniprot id: A0A2S7SE56
names: Similarity
messages: Belongs to the UPF0438 family.

564:LA347 RS04660
gene id: 564:LA347_RS04660
uniprot id: A0A7K4I262
names: Function
messages: May be involved in the biogenesis of curli organelles.

564:LA347 RS15210
gene id: 564:LA347_RS15210
uniprot id: A0A2S7SIF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

564:LA347 RS21895
gene id: 564:LA347_RS21895
uniprot id: A0A7K4HST2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
messages: Cell membrane
messages: Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
messages: Membrane

564:LA347 RS06180
gene id: 564:LA347_RS06180
uniprot id: A0A7K4I1A4
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family.
messages: Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.

564:LA347 RS17430
gene id: 564:LA347_RS17430
uniprot id: A0A7K4HVD9
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS02730
gene id: 564:LA347_RS02730
uniprot id: A0A7K4I3X5
names: Similarity
messages: Belongs to the UPF0352 family.

564:LA347 RS22030
gene id: 564:LA347_RS22030
uniprot id: A0A7K4HSL5
names: Similarity
messages: Belongs to the RecJ family.

564:LA347 RS14550
gene id: 564:LA347_RS14550
uniprot id: A0A7K4HWT9
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS01375
gene id: 564:LA347_RS01375
uniprot id: A0A7W3ECW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS01875
gene id: 564:LA347_RS01875
uniprot id: A0A2S7SNC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS14450
gene id: 564:LA347_RS14450
uniprot id: A0A7K4HWV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MzrA family.
messages: Cell inner membrane
messages: Interacts with EnvZ.
messages: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.

564:LA347 RS20975
gene id: 564:LA347_RS20975
uniprot id: A0A7L6RYU9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

564:LA347 RS05260
gene id: 564:LA347_RS05260
uniprot id: A0A7K4I1T0
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

564:LA347 RS17760
gene id: 564:LA347_RS17760
uniprot id: A0A7B5Q3Q6
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

564:LA347 RS08155
gene id: 564:LA347_RS08155
uniprot id: A0A7K4I173
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19610
gene id: 564:LA347_RS19610
uniprot id: A0A7B5TKM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
messages: Cell inner membrane
messages: Interacts with KefB.
messages: Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.

564:LA347 RS16130
gene id: 564:LA347_RS16130
uniprot id: A0A2S7SCF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

564:LA347 RS17475
gene id: 564:LA347_RS17475
uniprot id: A0A7K4HV56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

564:LA347 RS15400
gene id: 564:LA347_RS15400
uniprot id: A0A7K4HWA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

564:LA347 RS03585
gene id: 564:LA347_RS03585
uniprot id: A0A7W3ES60
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Homodimer.

564:LA347 RS22035
gene id: 564:LA347_RS22035
uniprot id: A0A7K4HSV5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

564:LA347 RS21045
gene id: 564:LA347_RS21045
uniprot id: A0A7K4HT60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.
messages: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
messages: Homodimer.

564:LA347 RS02965
gene id: 564:LA347_RS02965
uniprot id: A0A7L6VK21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

564:LA347 RS13380
gene id: 564:LA347_RS13380
uniprot id: A0A7W3I0K0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS11650
gene id: 564:LA347_RS11650
uniprot id: A0A7L6VIV2
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

564:LA347 RS17675
gene id: 564:LA347_RS17675
uniprot id: A0A7K4HV96
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

564:LA347 RS08360
gene id: 564:LA347_RS08360
uniprot id: A0A7K4I130
names: Similarity
messages: Belongs to the MotB family.

564:LA347 RS08070
gene id: 564:LA347_RS08070
uniprot id: A0A564V0V4
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TorC/TorY family.
messages: Binds 5 heme groups per subunit.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19780
gene id: 564:LA347_RS19780
uniprot id: A0A2S7SDP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

564:LA347 RS02635
gene id: 564:LA347_RS02635
uniprot id: A0A2S7SP70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

564:LA347 RS11330
gene id: 564:LA347_RS11330
uniprot id: A0A2S7SNK4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

564:LA347 RS04090
gene id: 564:LA347_RS04090
uniprot id: A0A7L6ZRX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

564:LA347 RS04125
gene id: 564:LA347_RS04125
uniprot id: A0A7K4I3B3
names: Similarity
messages: Belongs to the CcmL/EutN family.

564:LA347 RS20860
gene id: 564:LA347_RS20860
uniprot id: A0A7W3I0N8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

564:LA347 RS10390
gene id: 564:LA347_RS10390
uniprot id: A0A7W3HYL7
names: Similarity
messages: Belongs to the EutP/PduV family.

564:LA347 RS01830
gene id: 564:LA347_RS01830
uniprot id: A0A2S7SNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS08370
gene id: 564:LA347_RS08370
uniprot id: A0A7K4I118
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhC family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.

564:LA347 RS09025
gene id: 564:LA347_RS09025
uniprot id: A0A7K4HZU7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.

564:LA347 RS09175
gene id: 564:LA347_RS09175
uniprot id: A0A7K4HZI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

564:LA347 RS18240
gene id: 564:LA347_RS18240
uniprot id: A0A2S7SDI8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

564:LA347 RS02675
gene id: 564:LA347_RS02675
uniprot id: A0A564TWQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

564:LA347 RS13260
gene id: 564:LA347_RS13260
uniprot id: A0A7K4HXG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

564:LA347 RS01055
gene id: 564:LA347_RS01055
uniprot id: A0A7K4HT21
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

564:LA347 RS05070
gene id: 564:LA347_RS05070
uniprot id: A0A7K4I1Y5
names: Similarity
messages: Belongs to the MipA/OmpV family.

564:LA347 RS19765
gene id: 564:LA347_RS19765
uniprot id: A0A2S7SDW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

564:LA347 RS01215
gene id: 564:LA347_RS01215
uniprot id: A0A2S7SNY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. Component of the ClpAP and ClpXP complexes.

564:LA347 RS19715
gene id: 564:LA347_RS19715
uniprot id: A0A2S7SDX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

564:LA347 RS15315
gene id: 564:LA347_RS15315
uniprot id: A0A2S7SJ17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdD family.
messages: Cell membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

564:LA347 RS02460
gene id: 564:LA347_RS02460
uniprot id: A0A7K4I328
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

564:LA347 RS09870
gene id: 564:LA347_RS09870
uniprot id: A0A7K4HZ44
names: Similarity
messages: Belongs to the MlaA family.

564:LA347 RS19535
gene id: 564:LA347_RS19535
uniprot id: A0A7L6ZVC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

564:LA347 RS19165
gene id: 564:LA347_RS19165
uniprot id: A0A2S7SGC8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

564:LA347 RS10060
gene id: 564:LA347_RS10060
uniprot id: A0A7W3HZ70
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS06550
gene id: 564:LA347_RS06550
uniprot id: A0A7K4I124
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

564:LA347 RS13785
gene id: 564:LA347_RS13785
uniprot id: A0A7K4HXV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

564:LA347 RS01750
gene id: 564:LA347_RS01750
uniprot id: A0A7K4I3E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein L14 (rplN).

564:LA347 RS08375
gene id: 564:LA347_RS08375
uniprot id: A0A7K4I102
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

564:LA347 RS01580
gene id: 564:LA347_RS01580
uniprot id: A0A2S7SNL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
messages: Cell inner membrane
messages: Component of an export pathway for enterobactin.
messages: Membrane

564:LA347 RS05210
gene id: 564:LA347_RS05210
uniprot id: A0A7W3EEH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

564:LA347 RS07260
gene id: 564:LA347_RS07260
uniprot id: A0A7L6VY75
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

564:LA347 RS03000
gene id: 564:LA347_RS03000
uniprot id: A0A2S7SNY9
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS04025
gene id: 564:LA347_RS04025
uniprot id: A0A2S7SE78
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS14785
gene id: 564:LA347_RS14785
uniprot id: A0A7K4HWW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS07055
gene id: 564:LA347_RS07055
uniprot id: A0A7K4I0V5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

564:LA347 RS14285
gene id: 564:LA347_RS14285
uniprot id: A0A7L6ZY94
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein S18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS12880
gene id: 564:LA347_RS12880
uniprot id: A0A2S7SCR9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS15395
gene id: 564:LA347_RS15395
uniprot id: A0A7K4HX41
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Binds 1 copper ion per subunit.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in resistance toward heavy metals.

564:LA347 RS07580
gene id: 564:LA347_RS07580
uniprot id: A0A7K4I0M3
names: Function
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

564:LA347 RS06960
gene id: 564:LA347_RS06960
uniprot id: A0A7K4I1Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
messages: The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.

564:LA347 RS16850
gene id: 564:LA347_RS16850
uniprot id: A0A7K4HVH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell inner membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

564:LA347 RS18560
gene id: 564:LA347_RS18560
uniprot id: A0A7K4HUN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

564:LA347 RS12115
gene id: 564:LA347_RS12115
uniprot id: A0A2S7SGS3
names: Similarity
messages: Belongs to the peptidase A31 family.

564:LA347 RS10790
gene id: 564:LA347_RS10790
uniprot id: A0A7W3EPE3
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS16495
gene id: 564:LA347_RS16495
uniprot id: A0A7K4HVT8
names: Similarity
messages: Belongs to the UPF0381 family.

564:LA347 RS09680
gene id: 564:LA347_RS09680
uniprot id: A0A2S7SMK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS20920
gene id: 564:LA347_RS20920
uniprot id: A0A7T4NEK0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

564:LA347 RS20420
gene id: 564:LA347_RS20420
uniprot id: A0A7K4HUJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

564:LA347 RS11005
gene id: 564:LA347_RS11005
uniprot id: A0A7T4NA88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rusA family.
messages: Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.
messages: Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC.
messages: Homodimer.

564:LA347 RS20410
gene id: 564:LA347_RS20410
uniprot id: A0A2S7SHS2
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

564:LA347 RS05360
gene id: 564:LA347_RS05360
uniprot id: A0A7K4I1R7
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS14200
gene id: 564:LA347_RS14200
uniprot id: A0A7T4NA88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the rusA family.
messages: Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.
messages: Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC.
messages: Homodimer.

564:LA347 RS05035
gene id: 564:LA347_RS05035
uniprot id: A0A7K4I203
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS12655
gene id: 564:LA347_RS12655
uniprot id: A0A7K4HXR5
names: Function
names: Subunit
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
messages: The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau.

564:LA347 RS10190
gene id: 564:LA347_RS10190
uniprot id: A0A7K4I016
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

564:LA347 RS12645
gene id: 564:LA347_RS12645
uniprot id: A0A7L6VEZ0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

564:LA347 RS15205
gene id: 564:LA347_RS15205
uniprot id: A0A2S7SII4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

564:LA347 RS13315
gene id: 564:LA347_RS13315
uniprot id: A0A564UZM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

564:LA347 RS00915
gene id: 564:LA347_RS00915
uniprot id: A0A7K4HT58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IraP family.
messages: Cytoplasm
messages: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
messages: Interacts with RssB.

564:LA347 RS04850
gene id: 564:LA347_RS04850
uniprot id: A0A7K4I206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

564:LA347 RS19655
gene id: 564:LA347_RS19655
uniprot id: A0A7K4HTX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrH/TusB family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

564:LA347 RS10730
gene id: 564:LA347_RS10730
uniprot id: A0A564UXY2
names: Function
names: Similarity
messages: Belongs to the IscX family.
messages: May function as iron donor in the assembly of iron-sulfur clusters.

564:LA347 RS21695
gene id: 564:LA347_RS21695
uniprot id: A0A7L6VNJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

564:LA347 RS04085
gene id: 564:LA347_RS04085
uniprot id: A0A7K4I293
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

564:LA347 RS21940
gene id: 564:LA347_RS21940
uniprot id: A0A7K4HSQ6
names: Similarity
messages: Belongs to the UPF0149 family.

564:LA347 RS21905
gene id: 564:LA347_RS21905
uniprot id: A0A7K4HTB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LysR transcriptional regulatory family.
messages: Controls the transcription of genes involved in arginine and lysine metabolism.
messages: Homodimer.

564:LA347 RS15445
gene id: 564:LA347_RS15445
uniprot id: A0A7K4HXE5
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS21355
gene id: 564:LA347_RS21355
uniprot id: A0A7K4HU50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsP family.
messages: Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.
messages: Periplasm

564:LA347 RS17400
gene id: 564:LA347_RS17400
uniprot id: A0A2S7SBR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

564:LA347 RS13720
gene id: 564:LA347_RS13720
uniprot id: A0A2S7SJH0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

564:LA347 RS21470
gene id: 564:LA347_RS21470
uniprot id: A0A7K4HSW4
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

564:LA347 RS04890
gene id: 564:LA347_RS04890
uniprot id: A0A7K4I334
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

564:LA347 RS01065
gene id: 564:LA347_RS01065
uniprot id: A0A2S7SNV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

564:LA347 RS12760
gene id: 564:LA347_RS12760
uniprot id: A0A7K4HXR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS18435
gene id: 564:LA347_RS18435
uniprot id: A0A2S7SE03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

564:LA347 RS13500
gene id: 564:LA347_RS13500
uniprot id: A0A7K4HX95
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

564:LA347 RS20580
gene id: 564:LA347_RS20580
uniprot id: A0A2S7SHJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

564:LA347 RS05350
gene id: 564:LA347_RS05350
uniprot id: A0A7K4I2V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

564:LA347 RS18670
gene id: 564:LA347_RS18670
uniprot id: A0A7K4HV76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane.

564:LA347 RS13285
gene id: 564:LA347_RS13285
uniprot id: A0A7K4HXE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

564:LA347 RS07035
gene id: 564:LA347_RS07035
uniprot id: A0A7K4I0T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SlyA family.
messages: Homodimer.
messages: Transcription regulator that can specifically activate or repress expression of target genes.

564:LA347 RS12440
gene id: 564:LA347_RS12440
uniprot id: A0A2S7SGR4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS07625
gene id: 564:LA347_RS07625
uniprot id: A0A7K4I0K9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-92 and Arg-95) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form.

564:LA347 RS10070
gene id: 564:LA347_RS10070
uniprot id: A0A7W3EPX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

564:LA347 RS20490
gene id: 564:LA347_RS20490
uniprot id: A0A7K4HUK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

564:LA347 RS09385
gene id: 564:LA347_RS09385
uniprot id: A0A7L6S9P6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudI subfamily.
messages: Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
messages: Monomer.

564:LA347 RS14475
gene id: 564:LA347_RS14475
uniprot id: A0A7K4HXW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

564:LA347 RS14290
gene id: 564:LA347_RS14290
uniprot id: A0A2S7SJH4
names: Function
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.

564:LA347 RS13505
gene id: 564:LA347_RS13505
uniprot id: A0A7L6VU78
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

564:LA347 RS12030
gene id: 564:LA347_RS12030
uniprot id: A0A2S7SH42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

564:LA347 RS09345
gene id: 564:LA347_RS09345
uniprot id: A0A7K4HZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS06995
gene id: 564:LA347_RS06995
uniprot id: A0A7K4I126
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Proton-dependent permease that transports di- and tripeptides.

564:LA347 RS14995
gene id: 564:LA347_RS14995
uniprot id: A0A7L6ZXP3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

564:LA347 RS17300
gene id: 564:LA347_RS17300
uniprot id: A0A7K4HWA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

564:LA347 RS12960
gene id: 564:LA347_RS12960
uniprot id: A0A7L6RS82
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.

564:LA347 RS12110
gene id: 564:LA347_RS12110
uniprot id: A0A7W3HY33
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

564:LA347 RS08955
gene id: 564:LA347_RS08955
uniprot id: A0A7K4HZN1
names: Similarity
messages: Belongs to the UPF0145 family.

564:LA347 RS16060
gene id: 564:LA347_RS16060
uniprot id: A0A2S7SC23
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

564:LA347 RS00800
gene id: 564:LA347_RS00800
uniprot id: A0A8E4N7A5
names: Similarity
messages: Belongs to the Rht family.

564:LA347 RS04980
gene id: 564:LA347_RS04980
uniprot id: A0A7K4I342
names: Similarity
messages: Belongs to the UPF0227 family.

564:LA347 RS20185
gene id: 564:LA347_RS20185
uniprot id: A0A7K4HUA0
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

564:LA347 RS22260
gene id: 564:LA347_RS22260
uniprot id: A0A7W3EU44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane

564:LA347 RS09180
gene id: 564:LA347_RS09180
uniprot id: A0A7K4HZS9
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS07965
gene id: 564:LA347_RS07965
uniprot id: A0A7K4I065
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvB family.
messages: Forms a complex with RuvA.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.

564:LA347 RS04345
gene id: 564:LA347_RS04345
uniprot id: A0A7L6RW86
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS00270
gene id: 564:LA347_RS00270
uniprot id: A0A7K4HSJ1
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

564:LA347 RS02400
gene id: 564:LA347_RS02400
uniprot id: A0A7K4I3E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

564:LA347 RS02685
gene id: 564:LA347_RS02685
uniprot id: A0A564TWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

564:LA347 RS03015
gene id: 564:LA347_RS03015
uniprot id: A0A7W3HVY5
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

564:LA347 RS20005
gene id: 564:LA347_RS20005
uniprot id: A0A7K4HTT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

564:LA347 RS19060
gene id: 564:LA347_RS19060
uniprot id: A0A2S7SG27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

564:LA347 RS15730
gene id: 564:LA347_RS15730
uniprot id: A0A2S7SI64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

564:LA347 RS16925
gene id: 564:LA347_RS16925
uniprot id: A0A2S7SI23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

564:LA347 RS21425
gene id: 564:LA347_RS21425
uniprot id: A0A7K4HSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS18160
gene id: 564:LA347_RS18160
uniprot id: A0A7K4HV31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

564:LA347 RS01100
gene id: 564:LA347_RS01100
uniprot id: A0A2S7SMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

564:LA347 RS13755
gene id: 564:LA347_RS13755
uniprot id: A0A7W3HZ07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

564:LA347 RS08000
gene id: 564:LA347_RS08000
uniprot id: A0A7K4I166
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS18935
gene id: 564:LA347_RS18935
uniprot id: A0A7K4HUF1
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

564:LA347 RS09570
gene id: 564:LA347_RS09570
uniprot id: A0A7L6SA96
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS17660
gene id: 564:LA347_RS17660
uniprot id: A0A7K4HV15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
messages: Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS07985
gene id: 564:LA347_RS07985
uniprot id: A0A2S7SKW1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RuvC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.

564:LA347 RS17850
gene id: 564:LA347_RS17850
uniprot id: A0A7K4HUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

564:LA347 RS07385
gene id: 564:LA347_RS07385
uniprot id: A0A7L6RUW8
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

564:LA347 RS04885
gene id: 564:LA347_RS04885
uniprot id: A0A7K4I233
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

564:LA347 RS19695
gene id: 564:LA347_RS19695
uniprot id: A0A7K4HV06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

564:LA347 RS01655
gene id: 564:LA347_RS01655
uniprot id: A0A7K4I3I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

564:LA347 RS06880
gene id: 564:LA347_RS06880
uniprot id: A0A7K4I0Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

564:LA347 RS02900
gene id: 564:LA347_RS02900
uniprot id: A0A7K4I2S8
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS16335
gene id: 564:LA347_RS16335
uniprot id: A0A7K4HWV0
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

564:LA347 RS20080
gene id: 564:LA347_RS20080
uniprot id: A0A7K4HUT2
names: Function
names: Similarity
messages: Belongs to the peptidase U62 family.
messages: Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).

564:LA347 RS06430
gene id: 564:LA347_RS06430
uniprot id: A0A7K4I291
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

564:LA347 RS12785
gene id: 564:LA347_RS12785
uniprot id: A0A2S7SCS7
names: Similarity
messages: Belongs to the UPF0253 family.

564:LA347 RS19595
gene id: 564:LA347_RS19595
uniprot id: A0A7W3ELC6
names: Similarity
messages: Belongs to the UPF0270 family.

564:LA347 RS21935
gene id: 564:LA347_RS21935
uniprot id: A0A2S7SF35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

564:LA347 RS08490
gene id: 564:LA347_RS08490
uniprot id: A0A2S7SJY3
names: Similarity
messages: Belongs to the acylphosphatase family.

564:LA347 RS08720
gene id: 564:LA347_RS08720
uniprot id: A0A7K4HZR6
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

564:LA347 RS15990
gene id: 564:LA347_RS15990
uniprot id: A0A7K4HW17
names: Cofactor
messages: Can also use Mn(2+) ion.

564:LA347 RS03415
gene id: 564:LA347_RS03415
uniprot id: A0A7W3EDR3
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

564:LA347 RS06990
gene id: 564:LA347_RS06990
uniprot id: A0A7K4I127
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

564:LA347 RS05565
gene id: 564:LA347_RS05565
uniprot id: A0A7K4I2U0
names: Similarity
messages: Belongs to the YciI family.

564:LA347 RS09290
gene id: 564:LA347_RS09290
uniprot id: A0A7L7A0C8
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

564:LA347 RS04445
gene id: 564:LA347_RS04445
uniprot id: A0A7L6W095
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis.
messages: Role in flagellar biosynthesis.

564:LA347 RS16900
gene id: 564:LA347_RS16900
uniprot id: A0A2S7SIC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

564:LA347 RS08745
gene id: 564:LA347_RS08745
uniprot id: A0A7K4HZQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

564:LA347 RS15545
gene id: 564:LA347_RS15545
uniprot id: A0A7L6VEC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

564:LA347 RS10555
gene id: 564:LA347_RS10555
uniprot id: A0A7K4HYR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

564:LA347 RS09460
gene id: 564:LA347_RS09460
uniprot id: A0A7K4HZE3
names: Function
names: Similarity
messages: Belongs to the isochorismate synthase family.
messages: Catalyzes the conversion of chorismate to isochorismate.

564:LA347 RS09970
gene id: 564:LA347_RS09970
uniprot id: A0A7K4I059
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

564:LA347 RS20310
gene id: 564:LA347_RS20310
uniprot id: A0A7K4HTU4
names: Similarity
names: Subunit
messages: Belongs to the SIS family. GutQ/KpsF subfamily.
messages: Homotetramer.

564:LA347 RS07775
gene id: 564:LA347_RS07775
uniprot id: A0A2S7SKW4
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS13810
gene id: 564:LA347_RS13810
uniprot id: A0A7L6ZY36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

564:LA347 RS07630
gene id: 564:LA347_RS07630
uniprot id: A0A7K4I0L1
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family. NagK subfamily.
messages: Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.

564:LA347 RS05280
gene id: 564:LA347_RS05280
uniprot id: A0A7L6VJQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.
messages: Bacterial flagellum basal body
messages: Belongs to the YcgR family.
messages: Monomer. Interacts with the flagellar basal bodies.

564:LA347 RS01745
gene id: 564:LA347_RS01745
uniprot id: A0A7K4I3D7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

564:LA347 RS10475
gene id: 564:LA347_RS10475
uniprot id: A0A7K4HZW4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

564:LA347 RS07440
gene id: 564:LA347_RS07440
uniprot id: A0A7K4I1J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

564:LA347 RS20050
gene id: 564:LA347_RS20050
uniprot id: A0A2S7SH34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

564:LA347 RS03340
gene id: 564:LA347_RS03340
uniprot id: A0A7K4I2K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

564:LA347 RS10090
gene id: 564:LA347_RS10090
uniprot id: A0A7L7A030
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

564:LA347 RS14625
gene id: 564:LA347_RS14625
uniprot id: A0A7K4HWQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

564:LA347 RS11635
gene id: 564:LA347_RS11635
uniprot id: A0A2S7SBK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS21155
gene id: 564:LA347_RS21155
uniprot id: A0A7L6SBI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: Homooctamer.

564:LA347 RS17395
gene id: 564:LA347_RS17395
uniprot id: A0A2S7SBV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

564:LA347 RS13310
gene id: 564:LA347_RS13310
uniprot id: A0A7K4HXF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

564:LA347 RS20070
gene id: 564:LA347_RS20070
uniprot id: A0A7K4HUR0
names: Similarity
messages: Belongs to the RNase E/G family. RNase G subfamily.

564:LA347 RS17045
gene id: 564:LA347_RS17045
uniprot id: A0A7K4HWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS12830
gene id: 564:LA347_RS12830
uniprot id: A0A2S7SCZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

564:LA347 RS05945
gene id: 564:LA347_RS05945
uniprot id: A0A7K4I1G1
names: Similarity
messages: Belongs to the universal stress protein A family.

564:LA347 RS21455
gene id: 564:LA347_RS21455
uniprot id: A0A8E4IMH5
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

564:LA347 RS04655
gene id: 564:LA347_RS04655
uniprot id: A0A7L6RW42
names: Function
messages: May be involved in the biogenesis of curli organelles.

564:LA347 RS02395
gene id: 564:LA347_RS02395
uniprot id: A0A7K4I392
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

564:LA347 RS02385
gene id: 564:LA347_RS02385
uniprot id: A0A7T4NDG4
names: Similarity
messages: Belongs to the ModE family.

564:LA347 RS10580
gene id: 564:LA347_RS10580
uniprot id: A0A7K4HYZ0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

564:LA347 RS11430
gene id: 564:LA347_RS11430
uniprot id: A0A2S7SN23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

564:LA347 RS10205
gene id: 564:LA347_RS10205
uniprot id: A0A7K4HZQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

564:LA347 RS01220
gene id: 564:LA347_RS01220
uniprot id: A0A7L6VLX7
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

564:LA347 RS02885
gene id: 564:LA347_RS02885
uniprot id: A0A7K4I3U7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

564:LA347 RS09690
gene id: 564:LA347_RS09690
uniprot id: A0A7K4I0C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

564:LA347 RS05270
gene id: 564:LA347_RS05270
uniprot id: A0A7L6VWK7
names: Similarity
messages: Belongs to the peptidase S66 family.

564:LA347 RS05110
gene id: 564:LA347_RS05110
uniprot id: A0A2S7SGH3
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

564:LA347 RS15930
gene id: 564:LA347_RS15930
uniprot id: A0A7K4HWU7
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS02175
gene id: 564:LA347_RS02175
uniprot id: A0A2S7SNX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

564:LA347 RS20405
gene id: 564:LA347_RS20405
uniprot id: A0A7K4HTK9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS18430
gene id: 564:LA347_RS18430
uniprot id: A0A7K4HUR2
names: Subcellular Location Annotation
messages: Cell membrane

564:LA347 RS09510
gene id: 564:LA347_RS09510
uniprot id: A0A7K4HZC6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Membrane

564:LA347 RS10240
gene id: 564:LA347_RS10240
uniprot id: A0A7W3EPI8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

564:LA347 RS16565
gene id: 564:LA347_RS16565
uniprot id: A0A7K4HWB5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates expression of the rhaSR operon in response to L-rhamnose.
messages: Binds DNA as a dimer.
messages: Cytoplasm

564:LA347 RS01445
gene id: 564:LA347_RS01445
uniprot id: A0A564V0D2
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS04515
gene id: 564:LA347_RS04515
uniprot id: A0A7L6RW62
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

564:LA347 RS16735
gene id: 564:LA347_RS16735
uniprot id: A0A2S7SIC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS20175
gene id: 564:LA347_RS20175
uniprot id: A0A2S7SGZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

564:LA347 RS15385
gene id: 564:LA347_RS15385
uniprot id: A0A7K4HWD4
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

564:LA347 RS15580
gene id: 564:LA347_RS15580
uniprot id: A0A7L6VEW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

564:LA347 RS06825
gene id: 564:LA347_RS06825
uniprot id: A0A7K4I0Z0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS02265
gene id: 564:LA347_RS02265
uniprot id: A0A7K4I3H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

564:LA347 RS05780
gene id: 564:LA347_RS05780
uniprot id: A0A7K4I2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS20450
gene id: 564:LA347_RS20450
uniprot id: A0A7L6RZ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

564:LA347 RS11365
gene id: 564:LA347_RS11365
uniprot id: A0A564UYE6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

564:LA347 RS14360
gene id: 564:LA347_RS14360
uniprot id: A0A7K4HXY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Cell inner membrane
messages: Involved in succinate export with YjjP. Both proteins are required for export.
messages: Membrane
messages: The transporter is composed of YjjB and YjjP.

564:LA347 RS21140
gene id: 564:LA347_RS21140
uniprot id: A0A2S7SF67
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

564:LA347 RS13350
gene id: 564:LA347_RS13350
uniprot id: A0A7K4HXC9
names: Function
messages: Involved in control of the biosynthesis of leucine.

564:LA347 RS02745
gene id: 564:LA347_RS02745
uniprot id: A0A7K4I2V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

564:LA347 RS12520
gene id: 564:LA347_RS12520
uniprot id: A0A7K4HYU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

564:LA347 RS16760
gene id: 564:LA347_RS16760
uniprot id: A0A7W3EMF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS07870
gene id: 564:LA347_RS07870
uniprot id: A0A7K4I082
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopC family.
messages: Involved in copper resistance. Appears to be involved in copper uptake.
messages: Periplasm

564:LA347 RS15335
gene id: 564:LA347_RS15335
uniprot id: A0A2S7SIV5
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

564:LA347 RS02375
gene id: 564:LA347_RS02375
uniprot id: A0A7L6VXX7
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

564:LA347 RS17150
gene id: 564:LA347_RS17150
uniprot id: A0A2S7SI69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.

564:LA347 RS02475
gene id: 564:LA347_RS02475
uniprot id: A0A2S7SNP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

564:LA347 RS10695
gene id: 564:LA347_RS10695
uniprot id: A0A7K4HYN1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

564:LA347 RS07235
gene id: 564:LA347_RS07235
uniprot id: A0A7K4I0P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

564:LA347 RS07425
gene id: 564:LA347_RS07425
uniprot id: A0A7K4I0Q1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

564:LA347 RS10030
gene id: 564:LA347_RS10030
uniprot id: A0A2S7SM53
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS01715
gene id: 564:LA347_RS01715
uniprot id: A0A7L6VKN0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

564:LA347 RS01765
gene id: 564:LA347_RS01765
uniprot id: A0A7K4I3J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

564:LA347 RS20090
gene id: 564:LA347_RS20090
uniprot id: A0A2S7SHL3
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AaeX family.
messages: Cell membrane
messages: Positively coregulated with aaeA and aaeB by AaeR.

564:LA347 RS14490
gene id: 564:LA347_RS14490
uniprot id: A0A7K4HWT7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS08860
gene id: 564:LA347_RS08860
uniprot id: A0A7K4HZP4
names: Similarity
messages: Belongs to the ClpA/ClpB family.

564:LA347 RS12545
gene id: 564:LA347_RS12545
uniprot id: A0A7K4HXS8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

564:LA347 RS04060
gene id: 564:LA347_RS04060
uniprot id: A0A7K4I2I9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS08215
gene id: 564:LA347_RS08215
uniprot id: A0A7L6VUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0394 family.
messages: Membrane

564:LA347 RS04650
gene id: 564:LA347_RS04650
uniprot id: A0A7K4I250
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

564:LA347 RS21130
gene id: 564:LA347_RS21130
uniprot id: A0A7K4HT62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

564:LA347 RS16885
gene id: 564:LA347_RS16885
uniprot id: A0A564UAI7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

564:LA347 RS02365
gene id: 564:LA347_RS02365
uniprot id: A0A7W3I2W5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS18715
gene id: 564:LA347_RS18715
uniprot id: A0A7K4HUJ5
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS11545
gene id: 564:LA347_RS11545
uniprot id: A0A7K4HYD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

564:LA347 RS08255
gene id: 564:LA347_RS08255
uniprot id: A0A7K4I145
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

564:LA347 RS05470
gene id: 564:LA347_RS05470
uniprot id: A0A7L6VR00
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

564:LA347 RS17385
gene id: 564:LA347_RS17385
uniprot id: A0A7L6S0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

564:LA347 RS20200
gene id: 564:LA347_RS20200
uniprot id: A0A7W3HWP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS06410
gene id: 564:LA347_RS06410
uniprot id: A0A7L6S7Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

564:LA347 RS19870
gene id: 564:LA347_RS19870
uniprot id: A0A2S7SDK1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

564:LA347 RS16320
gene id: 564:LA347_RS16320
uniprot id: A0A7K4HVV8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS20000
gene id: 564:LA347_RS20000
uniprot id: A0A7K4HTP5
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

564:LA347 RS08180
gene id: 564:LA347_RS08180
uniprot id: A0A7L6S905
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

564:LA347 RS21880
gene id: 564:LA347_RS21880
uniprot id: A0A2S7SF45
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

564:LA347 RS00215
gene id: 564:LA347_RS00215
uniprot id: A0A7K4HSK2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS19650
gene id: 564:LA347_RS19650
uniprot id: A0A7K4HUK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrF/TusC family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

564:LA347 RS08220
gene id: 564:LA347_RS08220
uniprot id: A0A564T0C8
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

564:LA347 RS19740
gene id: 564:LA347_RS19740
uniprot id: A0A2S7SE33
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

564:LA347 RS17215
gene id: 564:LA347_RS17215
uniprot id: A0A7K4HV94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

564:LA347 RS12465
gene id: 564:LA347_RS12465
uniprot id: A0A7L6RSF4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.

564:LA347 RS13770
gene id: 564:LA347_RS13770
uniprot id: A0A7K4HY69
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

564:LA347 RS16465
gene id: 564:LA347_RS16465
uniprot id: A0A7K4HVU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

564:LA347 RS05715
gene id: 564:LA347_RS05715
uniprot id: A0A7K4I1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

564:LA347 RS14460
gene id: 564:LA347_RS14460
uniprot id: A0A7K4HWW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19710
gene id: 564:LA347_RS19710
uniprot id: A0A2S7SDM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

564:LA347 RS02895
gene id: 564:LA347_RS02895
uniprot id: A0A7K4I2R6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS21285
gene id: 564:LA347_RS21285
uniprot id: A0A7K4HTB3
names: Similarity
messages: Belongs to the UPF0441 family.

564:LA347 RS08805
gene id: 564:LA347_RS08805
uniprot id: A0A7K4HZQ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS08465
gene id: 564:LA347_RS08465
uniprot id: A0A7L6ZP88
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

564:LA347 RS21000
gene id: 564:LA347_RS21000
uniprot id: A0A7K4HT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HdeB family.
messages: Periplasm
messages: Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.

564:LA347 RS01665
gene id: 564:LA347_RS01665
uniprot id: A0A7K4I3L5
names: Similarity
messages: Belongs to the universal stress protein A family.

564:LA347 RS19670
gene id: 564:LA347_RS19670
uniprot id: A0A2S7SDN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

564:LA347 RS02935
gene id: 564:LA347_RS02935
uniprot id: A0A7K4I3T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

564:LA347 RS15055
gene id: 564:LA347_RS15055
uniprot id: A0A2S7SIK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.

564:LA347 RS22215
gene id: 564:LA347_RS22215
uniprot id: A0A2S7SB31
names: Similarity
messages: Belongs to the class-A beta-lactamase family.

564:LA347 RS07125
gene id: 564:LA347_RS07125
uniprot id: A0A7K4I0R3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS14430
gene id: 564:LA347_RS14430
uniprot id: A0A7K4HXL9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

564:LA347 RS01395
gene id: 564:LA347_RS01395
uniprot id: A0A2S7SNU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

564:LA347 RS08420
gene id: 564:LA347_RS08420
uniprot id: A0A7K4I107
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

564:LA347 RS09740
gene id: 564:LA347_RS09740
uniprot id: A0A7K4I0B9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS11970
gene id: 564:LA347_RS11970
uniprot id: A0A7K4HY53
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS20325
gene id: 564:LA347_RS20325
uniprot id: A0A7K4HTM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

564:LA347 RS08865
gene id: 564:LA347_RS08865
uniprot id: A0A7K4HZX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

564:LA347 RS10485
gene id: 564:LA347_RS10485
uniprot id: A0A7K4HZW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

564:LA347 RS07325
gene id: 564:LA347_RS07325
uniprot id: A0A7K4I0S1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

564:LA347 RS06145
gene id: 564:LA347_RS06145
uniprot id: A0A7K4I1D9
names: Similarity
messages: Belongs to the FrmR/RcnR family.

564:LA347 RS13150
gene id: 564:LA347_RS13150
uniprot id: A0A7K4HXG8
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

564:LA347 RS05255
gene id: 564:LA347_RS05255
uniprot id: A0A7L6ZR39
names: Function
names: Similarity
messages: Belongs to the DadA oxidoreductase family.
messages: Oxidative deamination of D-amino acids.

564:LA347 RS05315
gene id: 564:LA347_RS05315
uniprot id: A0A7K4I1U4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

564:LA347 RS21885
gene id: 564:LA347_RS21885
uniprot id: A0A2S7SEL8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

564:LA347 RS08875
gene id: 564:LA347_RS08875
uniprot id: A0A7K4HZW3
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS17775
gene id: 564:LA347_RS17775
uniprot id: A0A7K4HVN7
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

564:LA347 RS15540
gene id: 564:LA347_RS15540
uniprot id: A0A564UYW5
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

564:LA347 RS14425
gene id: 564:LA347_RS14425
uniprot id: A0A7W3EHL7
names: Similarity
messages: Belongs to the UxaA family.

564:LA347 RS13240
gene id: 564:LA347_RS13240
uniprot id: A0A7K4HXE2
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
messages: Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.

564:LA347 RS16570
gene id: 564:LA347_RS16570
uniprot id: A0A7K4HVM5
names: Caution
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Activates expression of the rhaBAD and rhaT operons.
messages: Binds DNA as a dimer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS20060
gene id: 564:LA347_RS20060
uniprot id: A0A7K4HTZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

564:LA347 RS15365
gene id: 564:LA347_RS15365
uniprot id: A0A7K4HWB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

564:LA347 RS12300
gene id: 564:LA347_RS12300
uniprot id: A0A2S7SGP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

564:LA347 RS02155
gene id: 564:LA347_RS02155
uniprot id: A0A564UZU4
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

564:LA347 RS00265
gene id: 564:LA347_RS00265
uniprot id: A0A7K4HT45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

564:LA347 RS20555
gene id: 564:LA347_RS20555
uniprot id: A0A7K4HTD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcdB/MmdB/OadB family.
messages: Beta subunit of the biotin-dependent malonate decarboxylase multienzyme complex (EC 7.2.4.4). Acts as an integral membrane-bound carboxybiotin protein decarboxylase by releasing the carboxyl group of the carboxylated biotin carrier MADF. The free energy of the decarboxylation reaction is used to pump Na(+) out of the cell.
messages: Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.
messages: Cell membrane
messages: Heterotrimer of an alpha, a beta and a gamma subunit.
messages: Membrane

564:LA347 RS08605
gene id: 564:LA347_RS08605
uniprot id: A0A7K4I032
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

564:LA347 RS20390
gene id: 564:LA347_RS20390
uniprot id: A0A2S7SH50
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

564:LA347 RS01615
gene id: 564:LA347_RS01615
uniprot id: A0A7L6VQC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

564:LA347 RS15340
gene id: 564:LA347_RS15340
uniprot id: A0A2S7SID0
names: Similarity
messages: Belongs to the EcnA/EcnB lipoprotein family.

564:LA347 RS02630
gene id: 564:LA347_RS02630
uniprot id: A0A2S7SPE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapF family.
messages: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

564:LA347 RS08495
gene id: 564:LA347_RS08495
uniprot id: A0A7K4HZW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.

564:LA347 RS20475
gene id: 564:LA347_RS20475
uniprot id: A0A7W3EFF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

564:LA347 RS07405
gene id: 564:LA347_RS07405
uniprot id: A0A7K4I0G5
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

564:LA347 RS13390
gene id: 564:LA347_RS13390
uniprot id: A0A7W3I1C5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS02605
gene id: 564:LA347_RS02605
uniprot id: A0A7K4I352
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane

564:LA347 RS09520
gene id: 564:LA347_RS09520
uniprot id: A0A2S7SMN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

564:LA347 RS06625
gene id: 564:LA347_RS06625
uniprot id: A0A7K4I251
names: Similarity
messages: Belongs to the Gfa family.

564:LA347 RS11510
gene id: 564:LA347_RS11510
uniprot id: A0A2S7SNE7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

564:LA347 RS00965
gene id: 564:LA347_RS00965
uniprot id: A0A7K4HT40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

564:LA347 RS09195
gene id: 564:LA347_RS09195
uniprot id: A0A7K4HZI3
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS21415
gene id: 564:LA347_RS21415
uniprot id: A0A7K4HSZ7
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.

564:LA347 RS16135
gene id: 564:LA347_RS16135
uniprot id: A0A2S7SCI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.
messages: Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA.

564:LA347 RS20300
gene id: 564:LA347_RS20300
uniprot id: A0A7K4HTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

564:LA347 RS06240
gene id: 564:LA347_RS06240
uniprot id: A0A7W3ERD5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS14355
gene id: 564:LA347_RS14355
uniprot id: A0A7K4HWY4
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

564:LA347 RS19005
gene id: 564:LA347_RS19005
uniprot id: A0A7K4HU89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

564:LA347 RS20130
gene id: 564:LA347_RS20130
uniprot id: A0A7K4HUS5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS10690
gene id: 564:LA347_RS10690
uniprot id: A0A7W3EPI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RodZ family.
messages: Cell inner membrane
messages: Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
messages: The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.

564:LA347 RS17240
gene id: 564:LA347_RS17240
uniprot id: A0A7K4HW82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

564:LA347 RS17805
gene id: 564:LA347_RS17805
uniprot id: A0A7W3I0L2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
messages: FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.

564:LA347 RS08275
gene id: 564:LA347_RS08275
uniprot id: A0A7L6RUI7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS02975
gene id: 564:LA347_RS02975
uniprot id: A0A7K4I3V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0299 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

564:LA347 RS04430
gene id: 564:LA347_RS04430
uniprot id: A0A7L6RWF9
names: Similarity
messages: Belongs to the DsrB family.

564:LA347 RS09465
gene id: 564:LA347_RS09465
uniprot id: A0A7K4HZC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS05615
gene id: 564:LA347_RS05615
uniprot id: A0A2S7SMA9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS13595
gene id: 564:LA347_RS13595
uniprot id: A0A2S7SJ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS19830
gene id: 564:LA347_RS19830
uniprot id: A0A564TJI9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

564:LA347 RS13025
gene id: 564:LA347_RS13025
uniprot id: A0A7L6ZYI2
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

564:LA347 RS14175
gene id: 564:LA347_RS14175
uniprot id: A0A4Y5RQF8
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS01705
gene id: 564:LA347_RS01705
uniprot id: A0A7K4I3H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatA/E family. TatE subfamily.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.

564:LA347 RS01975
gene id: 564:LA347_RS01975
uniprot id: A0A2S7SP25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS11615
gene id: 564:LA347_RS11615
uniprot id: A0A2S7SBP0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

564:LA347 RS10765
gene id: 564:LA347_RS10765
uniprot id: A0A2S7SN49
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster.
messages: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.

564:LA347 RS05710
gene id: 564:LA347_RS05710
uniprot id: A0A7K4I1U5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapA family.
messages: Cell inner membrane
messages: Involved in the assembly of lipopolysaccharide (LPS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS18790
gene id: 564:LA347_RS18790
uniprot id: A0A7K4HV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein B family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

564:LA347 RS05030
gene id: 564:LA347_RS05030
uniprot id: A0A7K4I335
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19960
gene id: 564:LA347_RS19960
uniprot id: A0A7K4HU06
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

564:LA347 RS16525
gene id: 564:LA347_RS16525
uniprot id: A0A7K4HVT2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS01610
gene id: 564:LA347_RS01610
uniprot id: A0A564SKE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioesterase PaaI family.
messages: Cytoplasm
messages: Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB.
messages: Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules.

564:LA347 RS14840
gene id: 564:LA347_RS14840
uniprot id: A0A7L6VTE7
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

564:LA347 RS14760
gene id: 564:LA347_RS14760
uniprot id: A0A7W3HXN7
names: Similarity
messages: Belongs to the RelB/DinJ antitoxin family.

564:LA347 RS10245
gene id: 564:LA347_RS10245
uniprot id: A0A7W3HYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

564:LA347 RS13495
gene id: 564:LA347_RS13495
uniprot id: A0A2S7SJ95
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

564:LA347 RS21505
gene id: 564:LA347_RS21505
uniprot id: A0A7K4HU20
names: Similarity
messages: Belongs to the HupF/HypC family.

564:LA347 RS20055
gene id: 564:LA347_RS20055
uniprot id: A0A7K4HTS9
names: Similarity
messages: Belongs to the MreC family.

564:LA347 RS22235
gene id: 564:LA347_RS22235
uniprot id: A0A7W3EKE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell inner membrane
messages: Membrane
messages: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.

564:LA347 RS05625
gene id: 564:LA347_RS05625
uniprot id: A0A7K4I2Q7
names: Function
messages: This protein is involved in control of the biosynthesis of tryptophan.

564:LA347 RS10795
gene id: 564:LA347_RS10795
uniprot id: A0A7K4HYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

564:LA347 RS19995
gene id: 564:LA347_RS19995
uniprot id: A0A2S7SH82
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

564:LA347 RS16265
gene id: 564:LA347_RS16265
uniprot id: A0A7W3EGU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

564:LA347 RS02270
gene id: 564:LA347_RS02270
uniprot id: A0A7K4I462
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

564:LA347 RS04845
gene id: 564:LA347_RS04845
uniprot id: A0A7K4I341
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

564:LA347 RS16145
gene id: 564:LA347_RS16145
uniprot id: A0A2S7SC21
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

564:LA347 RS12835
gene id: 564:LA347_RS12835
uniprot id: A0A2S7SCQ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
messages: Oligomer.
messages: The N-terminus is blocked.

564:LA347 RS13775
gene id: 564:LA347_RS13775
uniprot id: A0A7K4HX51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

564:LA347 RS16915
gene id: 564:LA347_RS16915
uniprot id: A0A7L6VCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

564:LA347 RS17460
gene id: 564:LA347_RS17460
uniprot id: A0A7W3EGD2
names: Similarity
names: Subunit
messages: Belongs to the ViaA family.
messages: Possible formation of a ternary complex RavA-ViaA-CadA.

564:LA347 RS04820
gene id: 564:LA347_RS04820
uniprot id: A0A7K4I2B9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

564:LA347 RS04100
gene id: 564:LA347_RS04100
uniprot id: A0A7L6VKF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

564:LA347 RS21910
gene id: 564:LA347_RS21910
uniprot id: A0A7L6VLN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

564:LA347 RS11420
gene id: 564:LA347_RS11420
uniprot id: A0A2S7SNM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

564:LA347 RS20605
gene id: 564:LA347_RS20605
uniprot id: A0A8E4ISK1
names: Similarity
messages: Belongs to the peptidase C56 family.

564:LA347 RS07295
gene id: 564:LA347_RS07295
uniprot id: A0A2S7SKK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

564:LA347 RS12660
gene id: 564:LA347_RS12660
uniprot id: A0A2S7SBG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

564:LA347 RS15515
gene id: 564:LA347_RS15515
uniprot id: A0A7K4HW98
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

564:LA347 RS17420
gene id: 564:LA347_RS17420
uniprot id: A0A2S7SBQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

564:LA347 RS15195
gene id: 564:LA347_RS15195
uniprot id: A0A7K4HWF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

564:LA347 RS01035
gene id: 564:LA347_RS01035
uniprot id: A0A7K4HRY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

564:LA347 RS13405
gene id: 564:LA347_RS13405
uniprot id: A0A7K4HXK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS02455
gene id: 564:LA347_RS02455
uniprot id: A0A7K4I439
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

564:LA347 RS19895
gene id: 564:LA347_RS19895
uniprot id: A0A7K4HUW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

564:LA347 RS12395
gene id: 564:LA347_RS12395
uniprot id: A0A7K4HY58
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

564:LA347 RS09210
gene id: 564:LA347_RS09210
uniprot id: A0A2S7SM43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity.
messages: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.
messages: nucleoid

564:LA347 RS19265
gene id: 564:LA347_RS19265
uniprot id: A0A2S7SFX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GlpE family.
messages: Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
messages: Cytoplasm

564:LA347 RS19630
gene id: 564:LA347_RS19630
uniprot id: A0A7K4HTX2
names: Similarity
messages: Belongs to the SlyX family.

564:LA347 RS21350
gene id: 564:LA347_RS21350
uniprot id: A0A7L6ZUB8
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

564:LA347 RS12865
gene id: 564:LA347_RS12865
uniprot id: A0A7K4HXN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

564:LA347 RS21345
gene id: 564:LA347_RS21345
uniprot id: A0A7K4HU21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

564:LA347 RS14700
gene id: 564:LA347_RS14700
uniprot id: A0A7K4HWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

564:LA347 RS15560
gene id: 564:LA347_RS15560
uniprot id: A0A7L6VRB5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class B bacterial acid phosphatase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homotetramer.
messages: Periplasm

564:LA347 RS20195
gene id: 564:LA347_RS20195
uniprot id: A0A7L6RZT5
names: Function
names: Similarity
messages: Belongs to the NanR family.
messages: Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.

564:LA347 RS04735
gene id: 564:LA347_RS04735
uniprot id: A0A7T4TDI5
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.

564:LA347 RS09105
gene id: 564:LA347_RS09105
uniprot id: A0A7K4I0K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
messages: Cytoplasm

564:LA347 RS08755
gene id: 564:LA347_RS08755
uniprot id: A0A7K4I001
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS21430
gene id: 564:LA347_RS21430
uniprot id: A0A7W3EEW4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

564:LA347 RS20400
gene id: 564:LA347_RS20400
uniprot id: A0A2S7SHC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

564:LA347 RS07315
gene id: 564:LA347_RS07315
uniprot id: A0A2S7SKI9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

564:LA347 RS21270
gene id: 564:LA347_RS21270
uniprot id: A0A7K4HT04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Belongs to the thioredoxin family. DsbL subfamily.
messages: Interacts with DsbI.
messages: Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT.
messages: Periplasm

564:LA347 RS02485
gene id: 564:LA347_RS02485
uniprot id: A0A564T5S7
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

564:LA347 RS02465
gene id: 564:LA347_RS02465
uniprot id: A0A7K4I421
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

564:LA347 RS16255
gene id: 564:LA347_RS16255
uniprot id: A0A564U3P0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
messages: Cytoplasm

564:LA347 RS14665
gene id: 564:LA347_RS14665
uniprot id: A0A7L6VDX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

564:LA347 RS01720
gene id: 564:LA347_RS01720
uniprot id: A0A2S7SP27
names: Similarity
messages: Belongs to the UPF0250 family.

564:LA347 RS19815
gene id: 564:LA347_RS19815
uniprot id: A0A2S7SDV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

564:LA347 RS14855
gene id: 564:LA347_RS14855
uniprot id: A0A7L6RQY5
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.

564:LA347 RS04965
gene id: 564:LA347_RS04965
uniprot id: A0A7K4I204
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LpoB family.
messages: Interacts with PBP1b.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).

564:LA347 RS10395
gene id: 564:LA347_RS10395
uniprot id: A0A564V3N7
names: Subcellular Location Annotation
messages: Bacterial microcompartment

564:LA347 RS21760
gene id: 564:LA347_RS21760
uniprot id: A0A7L6RYF9
names: Similarity
messages: Belongs to the EndA/NucM nuclease family.

564:LA347 RS12540
gene id: 564:LA347_RS12540
uniprot id: A0A7K4HXS6
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

564:LA347 RS03345
gene id: 564:LA347_RS03345
uniprot id: A0A2S7SPJ9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS04605
gene id: 564:LA347_RS04605
uniprot id: A0A7L6S6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

564:LA347 RS13510
gene id: 564:LA347_RS13510
uniprot id: A0A7W3ENG7
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

564:LA347 RS04900
gene id: 564:LA347_RS04900
uniprot id: A0A7K4I1Z5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

564:LA347 RS15925
gene id: 564:LA347_RS15925
uniprot id: A0A7K4HX63
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS14860
gene id: 564:LA347_RS14860
uniprot id: A0A7L6S3A1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily.
messages: Catalyzes the proton-dependent transport of glutamate and aspartate.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS21435
gene id: 564:LA347_RS21435
uniprot id: A0A7K4HT65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

564:LA347 RS20380
gene id: 564:LA347_RS20380
uniprot id: A0A2S7SH47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS12925
gene id: 564:LA347_RS12925
uniprot id: A0A7L6RS77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

564:LA347 RS04005
gene id: 564:LA347_RS04005
uniprot id: A0A7K4I2A4
names: Similarity
messages: Belongs to the CcmL/EutN family.

564:LA347 RS14635
gene id: 564:LA347_RS14635
uniprot id: A0A564SX86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

564:LA347 RS00305
gene id: 564:LA347_RS00305
uniprot id: A0A7K4HSK4
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS08315
gene id: 564:LA347_RS08315
uniprot id: A0A7L6S929
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

564:LA347 RS09530
gene id: 564:LA347_RS09530
uniprot id: A0A2S7SMG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

564:LA347 RS18260
gene id: 564:LA347_RS18260
uniprot id: A0A7K4HUT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell inner membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

564:LA347 RS01190
gene id: 564:LA347_RS01190
uniprot id: A0A7K4HRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Membrane

564:LA347 RS01940
gene id: 564:LA347_RS01940
uniprot id: A0A7K4I3A8
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

564:LA347 RS07015
gene id: 564:LA347_RS07015
uniprot id: A0A7K4I1W2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

564:LA347 RS12935
gene id: 564:LA347_RS12935
uniprot id: A0A7L6VET5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
messages: Homodimer.

564:LA347 RS19450
gene id: 564:LA347_RS19450
uniprot id: A0A7K4HUP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS19360
gene id: 564:LA347_RS19360
uniprot id: A0A7K4HU22
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

564:LA347 RS15390
gene id: 564:LA347_RS15390
uniprot id: A0A7K4HXG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

564:LA347 RS00285
gene id: 564:LA347_RS00285
uniprot id: A0A7K4HSG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS10200
gene id: 564:LA347_RS10200
uniprot id: A0A2S7SMV4
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS14725
gene id: 564:LA347_RS14725
uniprot id: A0A7W3ENA1
names: Function
names: Similarity
messages: Belongs to the transposase 8 family.
messages: Involved in the transposition of the insertion sequence IS2.

564:LA347 RS02780
gene id: 564:LA347_RS02780
uniprot id: A0A7K4I3W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS06575
gene id: 564:LA347_RS06575
uniprot id: A0A2S7SLL0
names: Function
names: Similarity
messages: Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein.
messages: Belongs to the SRA family.

564:LA347 RS17390
gene id: 564:LA347_RS17390
uniprot id: A0A2S7SC38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

564:LA347 RS08410
gene id: 564:LA347_RS08410
uniprot id: A0A7K4I121
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

564:LA347 RS02355
gene id: 564:LA347_RS02355
uniprot id: A0A2S7SNK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

564:LA347 RS03980
gene id: 564:LA347_RS03980
uniprot id: A0A7L6VX79
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS19825
gene id: 564:LA347_RS19825
uniprot id: A0A2S7SDL2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

564:LA347 RS12265
gene id: 564:LA347_RS12265
uniprot id: A0A7W3HZA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UbiX/PAD1 family. YclB subfamily.
messages: Homododecamer.
messages: Involved in the non-oxidative decarboxylation and detoxification of phenolic derivatives. Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase.

564:LA347 RS18010
gene id: 564:LA347_RS18010
uniprot id: A0A7K4HVK8
names: Similarity
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Homotrimer.

564:LA347 RS15435
gene id: 564:LA347_RS15435
uniprot id: A0A7K4HXC5
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

564:LA347 RS11880
gene id: 564:LA347_RS11880
uniprot id: A0A7K4HY57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

564:LA347 RS01870
gene id: 564:LA347_RS01870
uniprot id: A0A7K4I3B9
names: Similarity
messages: Belongs to the PhoH family.

564:LA347 RS10635
gene id: 564:LA347_RS10635
uniprot id: A0A7K4HZU5
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

564:LA347 RS18710
gene id: 564:LA347_RS18710
uniprot id: A0A7K4HUH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS17425
gene id: 564:LA347_RS17425
uniprot id: A0A7K4HV65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

564:LA347 RS07915
gene id: 564:LA347_RS07915
uniprot id: A0A7K4I077
names: Similarity
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Homotrimer.

564:LA347 RS20370
gene id: 564:LA347_RS20370
uniprot id: A0A2S7SH83
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

564:LA347 RS09565
gene id: 564:LA347_RS09565
uniprot id: A0A2S7SMB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

564:LA347 RS05265
gene id: 564:LA347_RS05265
uniprot id: A0A7K4I1V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
messages: Cell membrane
messages: K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.

564:LA347 RS17360
gene id: 564:LA347_RS17360
uniprot id: A0A7L6S1A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS16750
gene id: 564:LA347_RS16750
uniprot id: A0A8E4IGL4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

564:LA347 RS15715
gene id: 564:LA347_RS15715
uniprot id: A0A7K4HW63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

564:LA347 RS10575
gene id: 564:LA347_RS10575
uniprot id: A0A7K4HYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

564:LA347 RS18645
gene id: 564:LA347_RS18645
uniprot id: A0A7K4HUU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.
messages: Cell inner membrane

564:LA347 RS11750
gene id: 564:LA347_RS11750
uniprot id: A0A7W3EIB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS06455
gene id: 564:LA347_RS06455
uniprot id: A0A7K4I1C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GhoT/OrtT toxin family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS04495
gene id: 564:LA347_RS04495
uniprot id: A0A7L6RW70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

564:LA347 RS05510
gene id: 564:LA347_RS05510
uniprot id: A0A7K4I1Y7
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

564:LA347 RS10775
gene id: 564:LA347_RS10775
uniprot id: A0A564UZ83
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

564:LA347 RS17415
gene id: 564:LA347_RS17415
uniprot id: A0A2S7SBZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

564:LA347 RS11410
gene id: 564:LA347_RS11410
uniprot id: A0A2S7SMP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

564:LA347 RS19785
gene id: 564:LA347_RS19785
uniprot id: A0A2S7SDR3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

564:LA347 RS13765
gene id: 564:LA347_RS13765
uniprot id: A0A2S7SJS9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

564:LA347 RS07715
gene id: 564:LA347_RS07715
uniprot id: A0A564UDA3
names: Similarity
messages: Belongs to the UPF0181 family.

564:LA347 RS02980
gene id: 564:LA347_RS02980
uniprot id: A0A7K4I2S5
names: Function
names: Similarity
messages: Belongs to the Dus family. DusC subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.

564:LA347 RS08670
gene id: 564:LA347_RS08670
uniprot id: A0A8E4N6Q0
names: Similarity
messages: Belongs to the YkuD family.

564:LA347 RS01230
gene id: 564:LA347_RS01230
uniprot id: A0A2S7SN25
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

564:LA347 RS09270
gene id: 564:LA347_RS09270
uniprot id: A0A7K4HZF9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain.
messages: Belongs to the RcsC family.
messages: Cell inner membrane
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
messages: Interacts with RcsD.
messages: Membrane

564:LA347 RS12745
gene id: 564:LA347_RS12745
uniprot id: A0A2S7SD84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

564:LA347 RS03005
gene id: 564:LA347_RS03005
uniprot id: A0A7L6VL10
names: Similarity
messages: Belongs to the peptidase S11 family.

564:LA347 RS02940
gene id: 564:LA347_RS02940
uniprot id: A0A2S7SPD6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS10195
gene id: 564:LA347_RS10195
uniprot id: A0A7K4HYW0
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

564:LA347 RS20305
gene id: 564:LA347_RS20305
uniprot id: A0A7K4HTM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

564:LA347 RS05585
gene id: 564:LA347_RS05585
uniprot id: A0A7K4I1N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0259 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

564:LA347 RS14835
gene id: 564:LA347_RS14835
uniprot id: A0A7K4HWM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

564:LA347 RS12885
gene id: 564:LA347_RS12885
uniprot id: A0A2S7SD04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

564:LA347 RS22210
gene id: 564:LA347_RS22210
uniprot id: A0A564V296
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

564:LA347 RS04865
gene id: 564:LA347_RS04865
uniprot id: A0A7K4I219
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

564:LA347 RS06150
gene id: 564:LA347_RS06150
uniprot id: A0A7K4I2G0
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
messages: Homodimer.

564:LA347 RS19300
gene id: 564:LA347_RS19300
uniprot id: A0A7K4HU52
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

564:LA347 RS16690
gene id: 564:LA347_RS16690
uniprot id: A0A2S7SI11
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS15670
gene id: 564:LA347_RS15670
uniprot id: A0A7K4HW72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

564:LA347 RS13070
gene id: 564:LA347_RS13070
uniprot id: A0A7L6VUV4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

564:LA347 RS14495
gene id: 564:LA347_RS14495
uniprot id: A0A7W3EHJ3
names: Similarity
messages: Belongs to the pirin family.

564:LA347 RS17615
gene id: 564:LA347_RS17615
uniprot id: A0A7K4HV17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

564:LA347 RS13160
gene id: 564:LA347_RS13160
uniprot id: A0A7K4HXI2
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

564:LA347 RS17595
gene id: 564:LA347_RS17595
uniprot id: A0A7L6SDD2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS21790
gene id: 564:LA347_RS21790
uniprot id: A0A7K4HT05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgB family.
messages: Cytoplasm

564:LA347 RS01985
gene id: 564:LA347_RS01985
uniprot id: A0A2S7SNG0
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

564:LA347 RS10400
gene id: 564:LA347_RS10400
uniprot id: A0A7L6ZZV4
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

564:LA347 RS15330
gene id: 564:LA347_RS15330
uniprot id: A0A2S7SID6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

564:LA347 RS12990
gene id: 564:LA347_RS12990
uniprot id: A0A7W3HYL8
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

564:LA347 RS17640
gene id: 564:LA347_RS17640
uniprot id: A0A564V296
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

564:LA347 RS02845
gene id: 564:LA347_RS02845
uniprot id: A0A7L6RX40
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS04435
gene id: 564:LA347_RS04435
uniprot id: A0A7L6S786
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RcsA family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes.
messages: Interacts with RcsB.

564:LA347 RS21120
gene id: 564:LA347_RS21120
uniprot id: A0A7K4HUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
messages: Binds DNA as a monomer.
messages: Cytoplasm
messages: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.

564:LA347 RS05700
gene id: 564:LA347_RS05700
uniprot id: A0A7K4I1M3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.

564:LA347 RS11765
gene id: 564:LA347_RS11765
uniprot id: A0A7W3EP21
names: Similarity
messages: Belongs to the LacAB/RpiB family.

564:LA347 RS07410
gene id: 564:LA347_RS07410
uniprot id: A0A7W3EQU0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

564:LA347 RS11315
gene id: 564:LA347_RS11315
uniprot id: A0A2S7SMM5
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.

564:LA347 RS09855
gene id: 564:LA347_RS09855
uniprot id: A0A7L7A015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

564:LA347 RS08645
gene id: 564:LA347_RS08645
uniprot id: A0A7L6SA03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS11435
gene id: 564:LA347_RS11435
uniprot id: A0A564UYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

564:LA347 RS05285
gene id: 564:LA347_RS05285
uniprot id: A0A7K4I2Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

564:LA347 RS13265
gene id: 564:LA347_RS13265
uniprot id: A0A7K4HYG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

564:LA347 RS20155
gene id: 564:LA347_RS20155
uniprot id: A0A7K4HTM0
names: Similarity
messages: Belongs to the peptidase S1C family.

564:LA347 RS06235
gene id: 564:LA347_RS06235
uniprot id: A0A7W3HWJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

564:LA347 RS09950
gene id: 564:LA347_RS09950
uniprot id: A0A7L6RTG2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS10085
gene id: 564:LA347_RS10085
uniprot id: A0A564UUJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

564:LA347 RS07765
gene id: 564:LA347_RS07765
uniprot id: A0A7K4I0B4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably functions as a manganese efflux pump.

564:LA347 RS10595
gene id: 564:LA347_RS10595
uniprot id: A0A7K4HZU9
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

564:LA347 RS16490
gene id: 564:LA347_RS16490
uniprot id: A0A7K4HVT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm
messages: Required for resistance to DNA-damaging agents.

564:LA347 RS02470
gene id: 564:LA347_RS02470
uniprot id: A0A2S7SP39
names: Function
names: Similarity
messages: Belongs to the MoaB/Mog family.
messages: May be involved in the biosynthesis of molybdopterin.

564:LA347 RS19665
gene id: 564:LA347_RS19665
uniprot id: A0A2S7SDY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

564:LA347 RS04945
gene id: 564:LA347_RS04945
uniprot id: A0A7K4I319
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

564:LA347 RS11660
gene id: 564:LA347_RS11660
uniprot id: A0A2S7SBN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

564:LA347 RS05235
gene id: 564:LA347_RS05235
uniprot id: A0A7K4I2Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

564:LA347 RS17440
gene id: 564:LA347_RS17440
uniprot id: A0A7K4HW33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

564:LA347 RS18230
gene id: 564:LA347_RS18230
uniprot id: A0A7K4HUV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

564:LA347 RS09585
gene id: 564:LA347_RS09585
uniprot id: A0A7K4HZJ6
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS04480
gene id: 564:LA347_RS04480
uniprot id: A0A7L6VMH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Flagellar protein that affects chemotactic events.
messages: Membrane

564:LA347 RS07740
gene id: 564:LA347_RS07740
uniprot id: A0A7K4I0C3
names: Similarity
messages: Belongs to the UPF0053 family.

564:LA347 RS21915
gene id: 564:LA347_RS21915
uniprot id: A0A7L6SBQ9
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

564:LA347 RS13170
gene id: 564:LA347_RS13170
uniprot id: A0A7K4HXH2
names: Function
names: Subunit
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
messages: Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

564:LA347 RS05785
gene id: 564:LA347_RS05785
uniprot id: A0A7K4I2L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

564:LA347 RS20570
gene id: 564:LA347_RS20570
uniprot id: A0A564TK51
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

564:LA347 RS21685
gene id: 564:LA347_RS21685
uniprot id: A0A7K4HSV4
names: Similarity
messages: Belongs to the asparaginase 1 family.

564:LA347 RS03970
gene id: 564:LA347_RS03970
uniprot id: A0A7K4I2C7
names: Similarity
messages: Belongs to the EutP/PduV family.

564:LA347 RS10470
gene id: 564:LA347_RS10470
uniprot id: A0A2S7SN85
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS13905
gene id: 564:LA347_RS13905
uniprot id: A0A2S7SJ16
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

564:LA347 RS19775
gene id: 564:LA347_RS19775
uniprot id: A0A7K4HU40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

564:LA347 RS03430
gene id: 564:LA347_RS03430
uniprot id: A0A7W3EDW7
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

564:LA347 RS04470
gene id: 564:LA347_RS04470
uniprot id: A0A7L6S793
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

564:LA347 RS18055
gene id: 564:LA347_RS18055
uniprot id: A0A7K4HVY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

564:LA347 RS11210
gene id: 564:LA347_RS11210
uniprot id: A0A7K4HYP5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

564:LA347 RS08795
gene id: 564:LA347_RS08795
uniprot id: A0A7K4HZP2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

564:LA347 RS07120
gene id: 564:LA347_RS07120
uniprot id: A0A7K4I0T0
names: Domain
names: Function
names: Subunit
messages: Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.
messages: Homodimer.
messages: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.

564:LA347 RS20105
gene id: 564:LA347_RS20105
uniprot id: A0A7K4HTS0
names: Similarity
messages: Belongs to the barstar family.

564:LA347 RS02930
gene id: 564:LA347_RS02930
uniprot id: A0A7K4I2T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

564:LA347 RS01740
gene id: 564:LA347_RS01740
uniprot id: A0A7K4I4A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

564:LA347 RS10590
gene id: 564:LA347_RS10590
uniprot id: A0A7K4HYQ3
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

564:LA347 RS08685
gene id: 564:LA347_RS08685
uniprot id: A0A7K4HZR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukF family.
messages: Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
messages: nucleoid

564:LA347 RS16765
gene id: 564:LA347_RS16765
uniprot id: A0A7K4HWH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

564:LA347 RS21330
gene id: 564:LA347_RS21330
uniprot id: A0A7W3EUH1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS01950
gene id: 564:LA347_RS01950
uniprot id: A0A2S7SNE1
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Homohexamer; trimer of disulfide-linked dimers.

564:LA347 RS05775
gene id: 564:LA347_RS05775
uniprot id: A0A7K4I1L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

564:LA347 RS13200
gene id: 564:LA347_RS13200
uniprot id: A0A7L6VEN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-Me-Phe pilin family.
messages: Membrane

564:LA347 RS05750
gene id: 564:LA347_RS05750
uniprot id: A0A7W3HW89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNR ribonuclease family. RNase II subfamily.
messages: Cytoplasm
messages: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.

564:LA347 RS21650
gene id: 564:LA347_RS21650
uniprot id: A0A7K4HTZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.
messages: Broad-specificity transporter of purine and pyrimidine nucleosides. Transport is driven by a proton motive force.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS04620
gene id: 564:LA347_RS04620
uniprot id: A0A7K4I3B2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS11335
gene id: 564:LA347_RS11335
uniprot id: A0A7K4HYN7
names: Similarity
messages: Belongs to the P(II) protein family.

564:LA347 RS16150
gene id: 564:LA347_RS16150
uniprot id: A0A564UXT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NusG family.
messages: Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.
messages: Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.

564:LA347 RS18030
gene id: 564:LA347_RS18030
uniprot id: A0A7K4HUX0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

564:LA347 RS11895
gene id: 564:LA347_RS11895
uniprot id: A0A7K4HY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS01695
gene id: 564:LA347_RS01695
uniprot id: A0A7K4I3F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrcB (TC 9.B.71) family.
messages: Cell membrane
messages: Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane

564:LA347 RS09200
gene id: 564:LA347_RS09200
uniprot id: A0A7K4I0M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.
messages: Cell outer membrane

564:LA347 RS17030
gene id: 564:LA347_RS17030
uniprot id: A0A7W3HX47
names: Similarity
messages: Belongs to the porin LamB (TC 1.B.3) family.

564:LA347 RS20295
gene id: 564:LA347_RS20295
uniprot id: A0A7L6ZUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

564:LA347 RS03565
gene id: 564:LA347_RS03565
uniprot id: A0A7W3HW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

564:LA347 RS08735
gene id: 564:LA347_RS08735
uniprot id: A0A7K4HZR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

564:LA347 RS05370
gene id: 564:LA347_RS05370
uniprot id: A0A7T4TDE6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

564:LA347 RS02260
gene id: 564:LA347_RS02260
uniprot id: A0A2S7SP88
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

564:LA347 RS14415
gene id: 564:LA347_RS14415
uniprot id: A0A7K4HXX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

564:LA347 RS13820
gene id: 564:LA347_RS13820
uniprot id: A0A7K4HY59
names: Function
names: Similarity
messages: Belongs to the thr operon leader peptide family.
messages: This protein is involved in control of the biosynthesis of threonine.

564:LA347 RS19820
gene id: 564:LA347_RS19820
uniprot id: A0A2S7SDL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

564:LA347 RS03150
gene id: 564:LA347_RS03150
uniprot id: A0A8E4N7T3
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

564:LA347 RS20455
gene id: 564:LA347_RS20455
uniprot id: A0A7K4HTF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

564:LA347 RS19795
gene id: 564:LA347_RS19795
uniprot id: A0A2S7SE57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

564:LA347 RS15085
gene id: 564:LA347_RS15085
uniprot id: A0A7K4HWH2
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the HPS/KGPDC family. KGPDC subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.
messages: Homodimer.
messages: Induced by L-ascorbate. Repressed by UlaR.

564:LA347 RS04460
gene id: 564:LA347_RS04460
uniprot id: A0A7L6S742
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

564:LA347 RS08310
gene id: 564:LA347_RS08310
uniprot id: A0A7K4I004
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

564:LA347 RS02535
gene id: 564:LA347_RS02535
uniprot id: A0A2S7SPE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS09560
gene id: 564:LA347_RS09560
uniprot id: A0A2S7SLX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

564:LA347 RS20290
gene id: 564:LA347_RS20290
uniprot id: A0A7K4HTK4
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

564:LA347 RS19705
gene id: 564:LA347_RS19705
uniprot id: A0A2S7SDQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

564:LA347 RS20835
gene id: 564:LA347_RS20835
uniprot id: A0A7Z1SPC1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS22005
gene id: 564:LA347_RS22005
uniprot id: A0A2S7SEI2
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

564:LA347 RS04815
gene id: 564:LA347_RS04815
uniprot id: A0A7K4I229
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

564:LA347 RS18110
gene id: 564:LA347_RS18110
uniprot id: A0A7W3I060
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Belongs to the flavodoxin family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell membrane

564:LA347 RS02550
gene id: 564:LA347_RS02550
uniprot id: A0A564UY73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0194 family.
messages: Periplasm

564:LA347 RS12875
gene id: 564:LA347_RS12875
uniprot id: A0A2S7SCR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

564:LA347 RS04145
gene id: 564:LA347_RS04145
uniprot id: A0A7K4I2A6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS16330
gene id: 564:LA347_RS16330
uniprot id: A0A7K4HVW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transaldolase family. Type 3A subfamily.
messages: Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction.
messages: Cytoplasm
messages: Homodecamer.

564:LA347 RS20445
gene id: 564:LA347_RS20445
uniprot id: A0A2S7SHE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

564:LA347 RS01025
gene id: 564:LA347_RS01025
uniprot id: A0A2S7SNA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).
messages: The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.

564:LA347 RS20210
gene id: 564:LA347_RS20210
uniprot id: A0A7K4HTW4
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

564:LA347 RS14445
gene id: 564:LA347_RS14445
uniprot id: A0A7K4HWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS15935
gene id: 564:LA347_RS15935
uniprot id: A0A7K4HW22
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS01020
gene id: 564:LA347_RS01020
uniprot id: A0A2S7SNK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

564:LA347 RS06170
gene id: 564:LA347_RS06170
uniprot id: A0A7K4I1B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family.
messages: Membrane

564:LA347 RS05100
gene id: 564:LA347_RS05100
uniprot id: A0A2S7SGH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm
messages: Interacts with CII protein from phage lambda.
messages: Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease.

564:LA347 RS07305
gene id: 564:LA347_RS07305
uniprot id: A0A2S7SL38
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

564:LA347 RS08780
gene id: 564:LA347_RS08780
uniprot id: A0A564V1A4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

564:LA347 RS04140
gene id: 564:LA347_RS04140
uniprot id: A0A7K4I286
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS07320
gene id: 564:LA347_RS07320
uniprot id: A0A2S7SKI4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

564:LA347 RS11645
gene id: 564:LA347_RS11645
uniprot id: A0A2S7SC25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

564:LA347 RS11900
gene id: 564:LA347_RS11900
uniprot id: A0A7L6ZZ16
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

564:LA347 RS05670
gene id: 564:LA347_RS05670
uniprot id: A0A7L6VKE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

564:LA347 RS16425
gene id: 564:LA347_RS16425
uniprot id: A0A2S7SHZ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

564:LA347 RS20115
gene id: 564:LA347_RS20115
uniprot id: A0A7K4HTM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

564:LA347 RS15675
gene id: 564:LA347_RS15675
uniprot id: A0A7K4HW61
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

564:LA347 RS11915
gene id: 564:LA347_RS11915
uniprot id: A0A7K4HYC8
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

564:LA347 RS08830
gene id: 564:LA347_RS08830
uniprot id: A0A7L6VH83
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

564:LA347 RS12470
gene id: 564:LA347_RS12470
uniprot id: A0A7L6VSQ2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19295
gene id: 564:LA347_RS19295
uniprot id: A0A7K4HUS3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by ATP and maltotriose, which are both required for DNA binding.
messages: Belongs to the MalT family.
messages: Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
messages: Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.

564:LA347 RS16895
gene id: 564:LA347_RS16895
uniprot id: A0A7W3EGM0
names: Similarity
messages: Belongs to the bacterial reverse transcriptase family.

564:LA347 RS04765
gene id: 564:LA347_RS04765
uniprot id: A0A7K4I243
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

564:LA347 RS05720
gene id: 564:LA347_RS05720
uniprot id: A0A7L6ZQV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

564:LA347 RS07010
gene id: 564:LA347_RS07010
uniprot id: A0A7K4I1X7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS16455
gene id: 564:LA347_RS16455
uniprot id: A0A7K4HVS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

564:LA347 RS02245
gene id: 564:LA347_RS02245
uniprot id: A0A564V0V1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

564:LA347 RS20020
gene id: 564:LA347_RS20020
uniprot id: A0A7K4HUS8
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

564:LA347 RS05875
gene id: 564:LA347_RS05875
uniprot id: A0A7L6W0W8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

564:LA347 RS02170
gene id: 564:LA347_RS02170
uniprot id: A0A7K4I483
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

564:LA347 RS20125
gene id: 564:LA347_RS20125
uniprot id: A0A7K4HTR9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS13565
gene id: 564:LA347_RS13565
uniprot id: A0A7L6ZY47
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS10520
gene id: 564:LA347_RS10520
uniprot id: A0A7L6S5H4
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS04680
gene id: 564:LA347_RS04680
uniprot id: A0A7K4I3A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgC/AgfC family.
messages: Periplasm

564:LA347 RS17100
gene id: 564:LA347_RS17100
uniprot id: A0A7K4HW06
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family. DsdA subfamily.
messages: Monomer.

564:LA347 RS13365
gene id: 564:LA347_RS13365
uniprot id: A0A7L6S426
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

564:LA347 RS05105
gene id: 564:LA347_RS05105
uniprot id: A0A7K4I1V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs.
messages: Cytoplasm
messages: Interacts with TusE.

564:LA347 RS05095
gene id: 564:LA347_RS05095
uniprot id: A0A7K4I2Z7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

564:LA347 RS11560
gene id: 564:LA347_RS11560
uniprot id: A0A7K4HYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.

564:LA347 RS08850
gene id: 564:LA347_RS08850
uniprot id: A0A2S7SJV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

564:LA347 RS12170
gene id: 564:LA347_RS12170
uniprot id: A0A2S7SGT7
names: Similarity
messages: Belongs to the HupF/HypC family.

564:LA347 RS02450
gene id: 564:LA347_RS02450
uniprot id: A0A7L6VXW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS12180
gene id: 564:LA347_RS12180
uniprot id: A0A7W3HYQ5
names: Similarity
messages: Belongs to the HypE family.

564:LA347 RS10630
gene id: 564:LA347_RS10630
uniprot id: A0A7W3EPD4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

564:LA347 RS09695
gene id: 564:LA347_RS09695
uniprot id: A0A7K4HZ80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

564:LA347 RS14775
gene id: 564:LA347_RS14775
uniprot id: A0A2S7SJG0
names: Similarity
messages: Belongs to the UPF0307 family.

564:LA347 RS19875
gene id: 564:LA347_RS19875
uniprot id: A0A7K4HU16
names: Similarity
messages: Belongs to the DprA/Smf family.

564:LA347 RS15260
gene id: 564:LA347_RS15260
uniprot id: A0A7K4HWF0
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

564:LA347 RS13275
gene id: 564:LA347_RS13275
uniprot id: A0A7K4HYG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

564:LA347 RS21830
gene id: 564:LA347_RS21830
uniprot id: A0A7K4HSZ5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

564:LA347 RS07920
gene id: 564:LA347_RS07920
uniprot id: A0A7K4I068
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

564:LA347 RS01285
gene id: 564:LA347_RS01285
uniprot id: A0A2S7SN39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

564:LA347 RS17090
gene id: 564:LA347_RS17090
uniprot id: A0A7L6VDG9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS02840
gene id: 564:LA347_RS02840
uniprot id: A0A7K4I3T0
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

564:LA347 RS13940
gene id: 564:LA347_RS13940
uniprot id: A0A7K4HX10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

564:LA347 RS16485
gene id: 564:LA347_RS16485
uniprot id: A0A7W3EGT3
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

564:LA347 RS14605
gene id: 564:LA347_RS14605
uniprot id: A0A2S7SJJ8
names: Similarity
messages: Belongs to the UPF0102 family.

564:LA347 RS10365
gene id: 564:LA347_RS10365
uniprot id: A0A564V1Z6
names: Similarity
messages: Belongs to the CcmL/EutN family.

564:LA347 RS21820
gene id: 564:LA347_RS21820
uniprot id: A0A2S7SEU0
names: Function
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.
messages: Catalyzes the formation of putrescine from agmatine.

564:LA347 RS03360
gene id: 564:LA347_RS03360
uniprot id: A0A7L6W6G8
names: Similarity
messages: Belongs to the UPF0053 family.

564:LA347 RS03410
gene id: 564:LA347_RS03410
uniprot id: A0A2S7SP65
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS10755
gene id: 564:LA347_RS10755
uniprot id: A0A2S7SMG6
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

564:LA347 RS14435
gene id: 564:LA347_RS14435
uniprot id: A0A7K4HWU6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19805
gene id: 564:LA347_RS19805
uniprot id: A0A2S7SDN2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

564:LA347 RS04840
gene id: 564:LA347_RS04840
uniprot id: A0A7K4I345
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

564:LA347 RS12810
gene id: 564:LA347_RS12810
uniprot id: A0A2S7SCW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

564:LA347 RS03225
gene id: 564:LA347_RS03225
uniprot id: A0A7L6S670
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19700
gene id: 564:LA347_RS19700
uniprot id: A0A2S7SDN3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

564:LA347 RS07790
gene id: 564:LA347_RS07790
uniprot id: A0A7K4I0B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MgrB family.
messages: Cell membrane
messages: May form homooligomers. Probably interacts with the periplasmic domain of PhoQ.
messages: PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing. MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP.

564:LA347 RS07380
gene id: 564:LA347_RS07380
uniprot id: A0A7K4I1L4
names: Function
names: Similarity
messages: Activates the cell division inhibited by chromosomal DNA over-replication.
messages: Belongs to the CedA family.

564:LA347 RS08500
gene id: 564:LA347_RS08500
uniprot id: A0A7K4HZX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HspQ family.
messages: Cytoplasm
messages: Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.

564:LA347 RS12560
gene id: 564:LA347_RS12560
uniprot id: A0A7K4HYT5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS14545
gene id: 564:LA347_RS14545
uniprot id: A0A2S7SJ20
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS01120
gene id: 564:LA347_RS01120
uniprot id: A0A7K4HSI9
names: Similarity
messages: Belongs to the UPF0234 family.

564:LA347 RS13110
gene id: 564:LA347_RS13110
uniprot id: A0A2S7SJG7
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

564:LA347 RS04110
gene id: 564:LA347_RS04110
uniprot id: A0A8E4INM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes activation of the choline trimethylamine-lyase CutC under anaerobic conditions by generation of an organic free radical on a glycine residue, via an homolytic cleavage of S-adenosyl-L-methionine (SAM).

564:LA347 RS12610
gene id: 564:LA347_RS12610
uniprot id: A0A7K4HXR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: Homohexamer.

564:LA347 RS02870
gene id: 564:LA347_RS02870
uniprot id: A0A7K4I343
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IUNH family. RihB subfamily.
messages: Binds 1 Ca(2+) ion per monomer.
messages: Homotetramer.
messages: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides.

564:LA347 RS12915
gene id: 564:LA347_RS12915
uniprot id: A0A7K4HXN0
names: Similarity
messages: Belongs to the UPF0325 family.

564:LA347 RS04915
gene id: 564:LA347_RS04915
uniprot id: A0A2S7SFX4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

564:LA347 RS21005
gene id: 564:LA347_RS21005
uniprot id: A0A7K4HUC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS00235
gene id: 564:LA347_RS00235
uniprot id: A0A7L6VMV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
messages: In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
messages: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

564:LA347 RS08190
gene id: 564:LA347_RS08190
uniprot id: A0A7W3I1Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

564:LA347 RS08300
gene id: 564:LA347_RS08300
uniprot id: A0A7K4I081
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

564:LA347 RS17955
gene id: 564:LA347_RS17955
uniprot id: A0A7W3I072
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS14510
gene id: 564:LA347_RS14510
uniprot id: A0A7K4HX16
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
messages: Homohexamer; trimer of dimers.

564:LA347 RS08710
gene id: 564:LA347_RS08710
uniprot id: A0A7K4HZZ7
names: Similarity
messages: Belongs to the UPF0434 family.

564:LA347 RS19725
gene id: 564:LA347_RS19725
uniprot id: A0A2S7SDN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

564:LA347 RS19400
gene id: 564:LA347_RS19400
uniprot id: A0A7K4HUQ7
names: Similarity
messages: Belongs to the HSP15 family.

564:LA347 RS15655
gene id: 564:LA347_RS15655
uniprot id: A0A7K4HWZ2
names: Similarity
messages: Belongs to the Fur family.

564:LA347 RS21295
gene id: 564:LA347_RS21295
uniprot id: A0A7K4HU33
names: Function
names: Similarity
names: Subunit
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.
messages: Homodimer.

564:LA347 RS14710
gene id: 564:LA347_RS14710
uniprot id: A0A7L6VSE7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

564:LA347 RS20035
gene id: 564:LA347_RS20035
uniprot id: A0A7W3ELA7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

564:LA347 RS05725
gene id: 564:LA347_RS05725
uniprot id: A0A7K4I1M6
names: Similarity
messages: Belongs to the SUI1 family.

564:LA347 RS19800
gene id: 564:LA347_RS19800
uniprot id: A0A2S7SDL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

564:LA347 RS13455
gene id: 564:LA347_RS13455
uniprot id: A0A7K4HXJ9
names: Similarity
messages: Belongs to the DapA family.

564:LA347 RS16160
gene id: 564:LA347_RS16160
uniprot id: A0A7K4HVY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

564:LA347 RS16480
gene id: 564:LA347_RS16480
uniprot id: A0A2S7SHV2
names: Similarity
messages: Belongs to the FBPase class 2 family.

564:LA347 RS15620
gene id: 564:LA347_RS15620
uniprot id: A0A7K4HW78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane
messages: Required for nicotinamide riboside transport across the inner membrane.

564:LA347 RS01225
gene id: 564:LA347_RS01225
uniprot id: A0A7K4HRX1
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.
messages: Belongs to the peptidase S16 family.
messages: By accumulation of abnormal proteins, such as at high temperatures. Under stress conditions.
messages: Contains an allosteric site (distinct from its active site), whose occupancy by an unfolded polypeptide leads to enzyme activation.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity. ATP binding and hydrolysis do not affect the oligomeric state of the enzyme.

564:LA347 RS22040
gene id: 564:LA347_RS22040
uniprot id: A0A7K4HSN7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS17870
gene id: 564:LA347_RS17870
uniprot id: A0A7L6W1Z5
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

564:LA347 RS21520
gene id: 564:LA347_RS21520
uniprot id: A0A7W3EF10
names: Similarity
messages: In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family.

564:LA347 RS07105
gene id: 564:LA347_RS07105
uniprot id: A0A7K4I0U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

564:LA347 RS11865
gene id: 564:LA347_RS11865
uniprot id: A0A2S7SGN4
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

564:LA347 RS01835
gene id: 564:LA347_RS01835
uniprot id: A0A7L6RXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

564:LA347 RS09230
gene id: 564:LA347_RS09230
uniprot id: A0A7K4HZS1
names: Similarity
messages: Belongs to the MQO family.

564:LA347 RS18410
gene id: 564:LA347_RS18410
uniprot id: A0A7K4HUP9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS16530
gene id: 564:LA347_RS16530
uniprot id: A0A7K4HWV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
messages: Cell inner membrane
messages: Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
messages: Homodimer.
messages: Membrane

564:LA347 RS17125
gene id: 564:LA347_RS17125
uniprot id: A0A7L6S0P7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

564:LA347 RS15295
gene id: 564:LA347_RS15295
uniprot id: A0A7K4HX59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
messages: Homodimer.
messages: With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF-P 'Lys-34'.

564:LA347 RS07210
gene id: 564:LA347_RS07210
uniprot id: A0A564UQ38
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

564:LA347 RS21145
gene id: 564:LA347_RS21145
uniprot id: A0A564V2G6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

564:LA347 RS21970
gene id: 564:LA347_RS21970
uniprot id: A0A564TBE4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

564:LA347 RS02760
gene id: 564:LA347_RS02760
uniprot id: A0A7L6RWY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS18990
gene id: 564:LA347_RS18990
uniprot id: A0A7K4HVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

564:LA347 RS19745
gene id: 564:LA347_RS19745
uniprot id: A0A2S7SE68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

564:LA347 RS17270
gene id: 564:LA347_RS17270
uniprot id: A4GWJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Membrane

564:LA347 RS18470
gene id: 564:LA347_RS18470
uniprot id: A0A7W3EG07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS15690
gene id: 564:LA347_RS15690
uniprot id: A0A7L6VF58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Monomer.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

564:LA347 RS05500
gene id: 564:LA347_RS05500
uniprot id: A0A7K4I1Y9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS16585
gene id: 564:LA347_RS16585
uniprot id: A0A7K4HVL7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aldolase class II family. RhaD subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS18235
gene id: 564:LA347_RS18235
uniprot id: A0A7L6S072
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

564:LA347 RS15710
gene id: 564:LA347_RS15710
uniprot id: A0A7K4HW58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
messages: Periplasm

564:LA347 RS05000
gene id: 564:LA347_RS05000
uniprot id: A0A7K4I1X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

564:LA347 RS16120
gene id: 564:LA347_RS16120
uniprot id: A0A7K4HVZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

564:LA347 RS10700
gene id: 564:LA347_RS10700
uniprot id: A0A2S7SMS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

564:LA347 RS09455
gene id: 564:LA347_RS09455
uniprot id: A0A8E4ILE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

564:LA347 RS05490
gene id: 564:LA347_RS05490
uniprot id: A0A7K4I1R5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

564:LA347 RS08600
gene id: 564:LA347_RS08600
uniprot id: A0A7K4HZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapC family.
messages: Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
messages: Cytoplasm
messages: Interacts directly with FtsZ.

564:LA347 RS04740
gene id: 564:LA347_RS04740
uniprot id: A0A7L6VZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0312 family. Type 1 subfamily.
messages: Periplasm

564:LA347 RS12295
gene id: 564:LA347_RS12295
uniprot id: A0A7K4HXY6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

564:LA347 RS20595
gene id: 564:LA347_RS20595
uniprot id: A0A7K4HU15
names: Similarity
messages: Belongs to the UPF0213 family.

564:LA347 RS13750
gene id: 564:LA347_RS13750
uniprot id: A0A7L6ZY68
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS02695
gene id: 564:LA347_RS02695
uniprot id: A0A2S7SNS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

564:LA347 RS21410
gene id: 564:LA347_RS21410
uniprot id: A0A7K4HTL2
names: Subunit
messages: Monomer.

564:LA347 RS15065
gene id: 564:LA347_RS15065
uniprot id: A0A2S7SJ13
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with S18 to 16S ribosomal RNA.

564:LA347 RS12330
gene id: 564:LA347_RS12330
uniprot id: A0A2S7SGP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

564:LA347 RS04020
gene id: 564:LA347_RS04020
uniprot id: A0A7L6VZW0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

564:LA347 RS17025
gene id: 564:LA347_RS17025
uniprot id: A0A7L6VTN5
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

564:LA347 RS11605
gene id: 564:LA347_RS11605
uniprot id: A0A7K4HYB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein S19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein S19.

564:LA347 RS14540
gene id: 564:LA347_RS14540
uniprot id: A0A564U7I1
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS20360
gene id: 564:LA347_RS20360
uniprot id: A0A7K4HTT9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

564:LA347 RS11990
gene id: 564:LA347_RS11990
uniprot id: A0A7L6S4R7
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

564:LA347 RS09255
gene id: 564:LA347_RS09255
uniprot id: A0A7L6VI69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

564:LA347 RS15760
gene id: 564:LA347_RS15760
uniprot id: A0A790WK77
names: Similarity
messages: Belongs to the aspartokinase family.

564:LA347 RS08885
gene id: 564:LA347_RS08885
uniprot id: A0A7K4HZN9
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

564:LA347 RS08395
gene id: 564:LA347_RS08395
uniprot id: A0A7K4HZY3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS05275
gene id: 564:LA347_RS05275
uniprot id: A0A7K4I228
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.

564:LA347 RS01170
gene id: 564:LA347_RS01170
uniprot id: A0A2S7SNN3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

564:LA347 RS21740
gene id: 564:LA347_RS21740
uniprot id: A0A2S7SEN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

564:LA347 RS04015
gene id: 564:LA347_RS04015
uniprot id: A0A7L6VZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

564:LA347 RS17405
gene id: 564:LA347_RS17405
uniprot id: A0A2S7SBP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

564:LA347 RS14930
gene id: 564:LA347_RS14930
uniprot id: A0A7K4HXC6
names: Similarity
messages: Belongs to the LacAB/RpiB family.

564:LA347 RS12435
gene id: 564:LA347_RS12435
uniprot id: A0A2S7SGY3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

564:LA347 RS18065
gene id: 564:LA347_RS18065
uniprot id: A0A7L6ZVZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

564:LA347 RS20180
gene id: 564:LA347_RS20180
uniprot id: A0A7K4HTQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

564:LA347 RS09505
gene id: 564:LA347_RS09505
uniprot id: A0A7L6S9N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

564:LA347 RS17245
gene id: 564:LA347_RS17245
uniprot id: A0A7K4HVA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

564:LA347 RS02970
gene id: 564:LA347_RS02970
uniprot id: A0A7K4I322
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS03570
gene id: 564:LA347_RS03570
uniprot id: A0A2S7SEF4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

564:LA347 RS10235
gene id: 564:LA347_RS10235
uniprot id: A0A7K4HZ43
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

564:LA347 RS19055
gene id: 564:LA347_RS19055
uniprot id: A0A2S7SG30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

564:LA347 RS13230
gene id: 564:LA347_RS13230
uniprot id: A0A7K4HY67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

564:LA347 RS21700
gene id: 564:LA347_RS21700
uniprot id: A0A7K4HSX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter small permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

564:LA347 RS15200
gene id: 564:LA347_RS15200
uniprot id: A0A564V0P2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

564:LA347 RS09010
gene id: 564:LA347_RS09010
uniprot id: A0A7L6RTK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

564:LA347 RS12275
gene id: 564:LA347_RS12275
uniprot id: A0A2S7SGZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

564:LA347 RS08515
gene id: 564:LA347_RS08515
uniprot id: A0A7K4I0Z4
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

564:LA347 RS10255
gene id: 564:LA347_RS10255
uniprot id: A0A7L6VG49
names: Function
names: Subunit
messages: Homotetramer.
messages: Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.

564:LA347 RS19345
gene id: 564:LA347_RS19345
uniprot id: A0A7L6VNV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

564:LA347 RS01670
gene id: 564:LA347_RS01670
uniprot id: A0A7K4I3S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rnk family.
messages: Interacts with the RNA polymerase.
messages: May act as an anti-Gre factor.

564:LA347 RS17665
gene id: 564:LA347_RS17665
uniprot id: A0A7L6W450
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homodimer.

564:LA347 RS11130
gene id: 564:LA347_RS11130
uniprot id: A0A2S7SNA2
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

564:LA347 RS19470
gene id: 564:LA347_RS19470
uniprot id: A0A7K4HU25
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

564:LA347 RS12620
gene id: 564:LA347_RS12620
uniprot id: A0A7W3EI06
names: Similarity
messages: Belongs to the YkuD family.

564:LA347 RS13295
gene id: 564:LA347_RS13295
uniprot id: A0A7L6VET7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

564:LA347 RS19000
gene id: 564:LA347_RS19000
uniprot id: A0A7K4HUB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcrB family.
messages: Cell membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. Essential for lipoprotein maturation under conditions where membrane fluidity may be altered.

564:LA347 RS07680
gene id: 564:LA347_RS07680
uniprot id: A0A7K4I0K2
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

564:LA347 RS11925
gene id: 564:LA347_RS11925
uniprot id: A0A7W3EP19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

564:LA347 RS09735
gene id: 564:LA347_RS09735
uniprot id: A0A7K4HZG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS19550
gene id: 564:LA347_RS19550
uniprot id: A0A7K4HUM4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

564:LA347 RS15275
gene id: 564:LA347_RS15275
uniprot id: A0A7K4HWH0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

564:LA347 RS12035
gene id: 564:LA347_RS12035
uniprot id: A0A7W3EP27
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Homotetramer.

564:LA347 RS13250
gene id: 564:LA347_RS13250
uniprot id: A0A7K4HXF2
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

564:LA347 RS15510
gene id: 564:LA347_RS15510
uniprot id: A0A7K4HW97
names: Similarity
messages: Belongs to the YjdM family.

564:LA347 RS19685
gene id: 564:LA347_RS19685
uniprot id: A0A7K4HUY3
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

564:LA347 RS17770
gene id: 564:LA347_RS17770
uniprot id: A0A7L7A0X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-1 family.
messages: Cytoplasm

564:LA347 RS12895
gene id: 564:LA347_RS12895
uniprot id: A0A7L6ZYH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

564:LA347 RS07185
gene id: 564:LA347_RS07185
uniprot id: A0A7W3I099
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YkuD family.
messages: Periplasm

564:LA347 RS07750
gene id: 564:LA347_RS07750
uniprot id: A0A7K4I1B7
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS05495
gene id: 564:LA347_RS05495
uniprot id: A0A7K4I1Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

564:LA347 RS04805
gene id: 564:LA347_RS04805
uniprot id: A0A7K4I222
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

564:LA347 RS08560
gene id: 564:LA347_RS08560
uniprot id: A0A7K4I030
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

564:LA347 RS15105
gene id: 564:LA347_RS15105
uniprot id: A0A7K4HWP4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UlaG family.
messages: Cytoplasm
messages: Induced by L-ascorbate. Repressed by UlaR.
messages: Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions.

564:LA347 RS15450
gene id: 564:LA347_RS15450
uniprot id: A0A7K4HX31
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS09685
gene id: 564:LA347_RS09685
uniprot id: A0A7L7A046
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

564:LA347 RS21275
gene id: 564:LA347_RS21275
uniprot id: A0A7L6VNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aryl sulfotransferase family.
messages: Catalyzes the transfer of sulfuryl groups between phenolic compounds.
messages: Periplasm

564:LA347 RS17365
gene id: 564:LA347_RS17365
uniprot id: A0A2S7SHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

564:LA347 RS04465
gene id: 564:LA347_RS04465
uniprot id: A0A7L6ZRI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

564:LA347 RS21995
gene id: 564:LA347_RS21995
uniprot id: A0A7K4HTP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

564:LA347 RS10800
gene id: 564:LA347_RS10800
uniprot id: A0A7K4HZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS03195
gene id: 564:LA347_RS03195
uniprot id: A0A7L6S664
names: Similarity
messages: Belongs to the FGGY kinase family.

564:LA347 RS10490
gene id: 564:LA347_RS10490
uniprot id: A0A7K4HZL1
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS05205
gene id: 564:LA347_RS05205
uniprot id: A0A7K4I1U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.
messages: Membrane

564:LA347 RS05675
gene id: 564:LA347_RS05675
uniprot id: A0A7K4I2P8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS16355
gene id: 564:LA347_RS16355
uniprot id: A0A2S7SIC8
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

564:LA347 RS12380
gene id: 564:LA347_RS12380
uniprot id: A0A564V2V8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS08980
gene id: 564:LA347_RS08980
uniprot id: A0A7L6VWW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

564:LA347 RS05395
gene id: 564:LA347_RS05395
uniprot id: A0A7K4I1T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

564:LA347 RS09525
gene id: 564:LA347_RS09525
uniprot id: A0A2S7SMT0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

564:LA347 RS13325
gene id: 564:LA347_RS13325
uniprot id: A0A7K4HYF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.
messages: nucleoid

564:LA347 RS19025
gene id: 564:LA347_RS19025
uniprot id: A0A7K4HU87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

564:LA347 RS20815
gene id: 564:LA347_RS20815
uniprot id: A0A7K4HTA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

564:LA347 RS15565
gene id: 564:LA347_RS15565
uniprot id: A0A8E4ILR6
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS19625
gene id: 564:LA347_RS19625
uniprot id: A0A7K4HU67
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

564:LA347 RS01710
gene id: 564:LA347_RS01710
uniprot id: A0A7K4I3F1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

564:LA347 RS19205
gene id: 564:LA347_RS19205
uniprot id: A0A7K4HU54
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

564:LA347 RS15165
gene id: 564:LA347_RS15165
uniprot id: A0A2S7SIG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

564:LA347 RS19410
gene id: 564:LA347_RS19410
uniprot id: A0A7B5TN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IgaA family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS18180
gene id: 564:LA347_RS18180
uniprot id: A0A7K4HVW1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

564:LA347 RS17655
gene id: 564:LA347_RS17655
uniprot id: A0A7L6SDC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzzB/Cld/Rol family.
messages: Cell inner membrane
messages: Membrane
messages: Modulates the polysaccharide chain length of enterobacterial common antigen (ECA).
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

564:LA347 RS07640
gene id: 564:LA347_RS07640
uniprot id: A0A7K4I0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

564:LA347 RS08640
gene id: 564:LA347_RS08640
uniprot id: A0A7K4HZT2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

564:LA347 RS20585
gene id: 564:LA347_RS20585
uniprot id: A0A2S7SHC0
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

564:LA347 RS08525
gene id: 564:LA347_RS08525
uniprot id: A0A7K4I0Y7
names: Subcellular Location Annotation
messages: Cell inner membrane

564:LA347 RS10585
gene id: 564:LA347_RS10585
uniprot id: A0A7K4HZV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

564:LA347 RS11475
gene id: 564:LA347_RS11475
uniprot id: A0A7K4HYE4
names: Function
messages: Acts as a radical domain for damaged PFL and possibly other radical proteins.

564:LA347 RS16890
gene id: 564:LA347_RS16890
uniprot id: A0A7K4HW51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

564:LA347 RS20470
gene id: 564:LA347_RS20470
uniprot id: A0A2S7SHR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

564:LA347 RS21670
gene id: 564:LA347_RS21670
uniprot id: A0A2S7SEX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Monomer.

564:LA347 RS20065
gene id: 564:LA347_RS20065
uniprot id: A0A7K4HTN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

564:LA347 RS19065
gene id: 564:LA347_RS19065
uniprot id: A0A7W3EFX9
names: Similarity
messages: Belongs to the leucine-binding protein family.

564:LA347 RS11585
gene id: 564:LA347_RS11585
uniprot id: A0A7K4HZD2
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

564:LA347 RS19720
gene id: 564:LA347_RS19720
uniprot id: A0A2S7SDM9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

564:LA347 RS05975
gene id: 564:LA347_RS05975
uniprot id: A0A7K4I2I2
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

564:LA347 RS17835
gene id: 564:LA347_RS17835
uniprot id: A0A7K4HVM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

564:LA347 RS04935
gene id: 564:LA347_RS04935
uniprot id: A0A7K4I223
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

564:LA347 RS07255
gene id: 564:LA347_RS07255
uniprot id: A0A7K4I0Y0
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

564:LA347 RS20460
gene id: 564:LA347_RS20460
uniprot id: A0A2S7SH67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

564:LA347 RS16905
gene id: 564:LA347_RS16905
uniprot id: A0A7W3EGK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

564:LA347 RS11460
gene id: 564:LA347_RS11460
uniprot id: A0A564UY90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. SrmB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
messages: Interacts with the 50S ribosomal subunit.

564:LA347 RS12525
gene id: 564:LA347_RS12525
uniprot id: A0A7K4HYJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS16660
gene id: 564:LA347_RS16660
uniprot id: A0A564UM66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

564:LA347 RS19755
gene id: 564:LA347_RS19755
uniprot id: A0A2S7SDP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

564:LA347 RS13745
gene id: 564:LA347_RS13745
uniprot id: A0A2S7SJ43
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

564:LA347 RS08965
gene id: 564:LA347_RS08965
uniprot id: A0A7K4HZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS20365
gene id: 564:LA347_RS20365
uniprot id: A0A2S7SHF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

564:LA347 RS16070
gene id: 564:LA347_RS16070
uniprot id: A0A564UZD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

564:LA347 RS20480
gene id: 564:LA347_RS20480
uniprot id: A0A564TK13
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: May be involved in cell division.

564:LA347 RS03600
gene id: 564:LA347_RS03600
uniprot id: A0A7K4I2M2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

564:LA347 RS12290
gene id: 564:LA347_RS12290
uniprot id: A0A7K4HXY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.

564:LA347 RS14720
gene id: 564:LA347_RS14720
uniprot id: A0A7L6VTG7
names: Similarity
names: Subunit
messages: Belongs to the RutC family.
messages: Homotrimer.

564:LA347 RS14945
gene id: 564:LA347_RS14945
uniprot id: A0A7K4HWK6
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS11595
gene id: 564:LA347_RS11595
uniprot id: A0A2S7SBN7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

564:LA347 RS11400
gene id: 564:LA347_RS11400
uniprot id: A0A7K4HZG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.
messages: Monomer.

564:LA347 RS13945
gene id: 564:LA347_RS13945
uniprot id: A0A2S7SJK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

564:LA347 RS19750
gene id: 564:LA347_RS19750
uniprot id: A0A2S7SDM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

564:LA347 RS10185
gene id: 564:LA347_RS10185
uniprot id: A0A7K4HZ51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

564:LA347 RS08195
gene id: 564:LA347_RS08195
uniprot id: A0A7L6S902
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

564:LA347 RS15635
gene id: 564:LA347_RS15635
uniprot id: A0A7K4HW89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. DnaB subfamily.
messages: Homohexamer.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

564:LA347 RS07085
gene id: 564:LA347_RS07085
uniprot id: A0A7K4I0S0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

564:LA347 RS02240
gene id: 564:LA347_RS02240
uniprot id: A0A7K4I347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS12750
gene id: 564:LA347_RS12750
uniprot id: A0A7K4HXQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RcsF family.
messages: Cell outer membrane
messages: Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects.

564:LA347 RS01690
gene id: 564:LA347_RS01690
uniprot id: A0A2S7SNB0
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS20355
gene id: 564:LA347_RS20355
uniprot id: A0A7K4HTL8
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

564:LA347 RS07135
gene id: 564:LA347_RS07135
uniprot id: A0A7K4I0Q9
names: Similarity
messages: Belongs to the CFA/CMAS family.

564:LA347 RS01475
gene id: 564:LA347_RS01475
uniprot id: A0A7K4I4I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hok/gef family.
messages: Cell inner membrane

564:LA347 RS13100
gene id: 564:LA347_RS13100
uniprot id: A0A7L6VSE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS09265
gene id: 564:LA347_RS09265
uniprot id: A0A7K4HZF6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RcsB family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner.
messages: Interacts with RcsD and RcsA.
messages: Phosphorylated and activated by RcsD.

564:LA347 RS01030
gene id: 564:LA347_RS01030
uniprot id: A0A7K4HRX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

564:LA347 RS07700
gene id: 564:LA347_RS07700
uniprot id: A0A7K4I1D3
names: Similarity
messages: Belongs to the RutC family.

564:LA347 RS05200
gene id: 564:LA347_RS05200
uniprot id: A0A7K4I2X8
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

564:LA347 RS08925
gene id: 564:LA347_RS08925
uniprot id: A0A7K4HZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

564:LA347 RS01725
gene id: 564:LA347_RS01725
uniprot id: A0A7K4I4E8
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

564:LA347 RS02285
gene id: 564:LA347_RS02285
uniprot id: A0A7K4I423
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

564:LA347 RS05530
gene id: 564:LA347_RS05530
uniprot id: A0A7K4I2S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

564:LA347 RS07180
gene id: 564:LA347_RS07180
uniprot id: A0A7K4I0S2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cell wall

564:LA347 RS05940
gene id: 564:LA347_RS05940
uniprot id: A0A7K4I1E2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

564:LA347 RS19690
gene id: 564:LA347_RS19690
uniprot id: A0A7K4I5B9
names: Similarity
messages: Belongs to the peptidase A24 family.

564:LA347 RS21720
gene id: 564:LA347_RS21720
uniprot id: A0A2S7SEW0
names: Similarity
messages: Belongs to the UPF0235 family.

564:LA347 RS16155
gene id: 564:LA347_RS16155
uniprot id: A0A2S7SCB2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS17065
gene id: 564:LA347_RS17065
uniprot id: A0A564S9E1
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Dimer of large and small chains.

564:LA347 RS10005
gene id: 564:LA347_RS10005
uniprot id: A0A7K4HZ82
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS09185
gene id: 564:LA347_RS09185
uniprot id: A0A7W3EQ27
names: Function
names: Similarity
messages: Belongs to the DtxR/MntR family.
messages: In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.

564:LA347 RS08445
gene id: 564:LA347_RS08445
uniprot id: A0A7K4HZX3
names: Similarity
messages: Belongs to the HupG/HyaE family.

564:LA347 RS18485
gene id: 564:LA347_RS18485
uniprot id: A0A7K4HUQ5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS04725
gene id: 564:LA347_RS04725
uniprot id: A0A7T4TDS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Confers resistance to fosfomycin and deoxycholate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

564:LA347 RS02640
gene id: 564:LA347_RS02640
uniprot id: A0A2S7SNS1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

564:LA347 RS07610
gene id: 564:LA347_RS07610
uniprot id: A0A7L6RUH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

564:LA347 RS14715
gene id: 564:LA347_RS14715
uniprot id: A0A2S7SJ67
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

564:LA347 RS13355
gene id: 564:LA347_RS13355
uniprot id: A0A7K4HXL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homotetramer.

564:LA347 RS08775
gene id: 564:LA347_RS08775
uniprot id: A0A7K4I0U2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

564:LA347 RS10335
gene id: 564:LA347_RS10335
uniprot id: A0A564V2G7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

564:LA347 RS13610
gene id: 564:LA347_RS13610
uniprot id: A0A7L6VS52
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.

564:LA347 RS10165
gene id: 564:LA347_RS10165
uniprot id: A0A7L6RT36
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

564:LA347 RS22205
gene id: 564:LA347_RS22205
uniprot id: A0A564V255
names: Similarity
messages: Belongs to the transposase 7 family.

564:LA347 RS11255
gene id: 564:LA347_RS11255
uniprot id: A0A7W3I002
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

564:LA347 RS01045
gene id: 564:LA347_RS01045
uniprot id: A0A8E4N762
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.
messages: Cell outer membrane

564:LA347 RS12555
gene id: 564:LA347_RS12555
uniprot id: A0A7K4HXU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

564:LA347 RS21485
gene id: 564:LA347_RS21485
uniprot id: A0A7L6SBX6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

564:LA347 RS18765
gene id: 564:LA347_RS18765
uniprot id: A0A7L6SD04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

564:LA347 RS02210
gene id: 564:LA347_RS02210
uniprot id: A0A7K4I3C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylaspartate mutase GlmE subunit family.
messages: Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
messages: Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.

564:LA347 RS08550
gene id: 564:LA347_RS08550
uniprot id: A0A7K4HZW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MatP family.
messages: Cytoplasm
messages: Homodimer.
messages: Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.

564:LA347 RS20270
gene id: 564:LA347_RS20270
uniprot id: A0A7K4HUM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RapZ-like family. RapZ subfamily.
messages: Homotrimer.
messages: Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.

564:LA347 RS12310
gene id: 564:LA347_RS12310
uniprot id: A0A7K4HYY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

564:LA347 RS18290
gene id: 564:LA347_RS18290
uniprot id: A0A7L6VPD3
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

564:LA347 RS13010
gene id: 564:LA347_RS13010
uniprot id: A0A2S7SDC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

564:LA347 RS04810
gene id: 564:LA347_RS04810
uniprot id: A0A7W3HW82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

564:LA347 RS19790
gene id: 564:LA347_RS19790
uniprot id: A0A2S7SE22
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

564:LA347 RS16880
gene id: 564:LA347_RS16880
uniprot id: A0A7W3I0E2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

564:LA347 RS03595
gene id: 564:LA347_RS03595
uniprot id: A0A7K4I2E4
names: Function
names: Similarity
messages: Belongs to the HisL family.
messages: This protein is involved in the attenuation mechanism for the control of the expression of the his operon structural genes.

564:LA347 RS09715
gene id: 564:LA347_RS09715
uniprot id: A0A7K4HZ72
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS01080
gene id: 564:LA347_RS01080
uniprot id: A0A7K4HRW8
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

564:LA347 RS05180
gene id: 564:LA347_RS05180
uniprot id: A0A7K4I237
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

564:LA347 RS07830
gene id: 564:LA347_RS07830
uniprot id: A0A7W3EJU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

564:LA347 RS18105
gene id: 564:LA347_RS18105
uniprot id: A0A7L6SDW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

564:LA347 RS02890
gene id: 564:LA347_RS02890
uniprot id: A0A7K4I3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

564:LA347 RS07665
gene id: 564:LA347_RS07665
uniprot id: A0A7L6VW25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

564:LA347 RS13695
gene id: 564:LA347_RS13695
uniprot id: A0A7K4HX57
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS20145
gene id: 564:LA347_RS20145
uniprot id: A0A7K4HTL4
names: Similarity
messages: Belongs to the class-I fumarase family.

564:LA347 RS03575
gene id: 564:LA347_RS03575
uniprot id: A0A7K4I3E8
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

564:LA347 RS15485
gene id: 564:LA347_RS15485
uniprot id: A0A7W3EH43
names: Subcellular Location Annotation
messages: Cell inner membrane

564:LA347 RS11735
gene id: 564:LA347_RS11735
uniprot id: A0A7W3I2A2
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

564:LA347 RS10735
gene id: 564:LA347_RS10735
uniprot id: A0A7K4HYV6
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

564:LA347 RS09595
gene id: 564:LA347_RS09595
uniprot id: A0A7K4HZA0
names: Similarity
messages: Belongs to the UPF0304 family.

564:LA347 RS12285
gene id: 564:LA347_RS12285
uniprot id: A0A7K4HXY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

564:LA347 RS01865
gene id: 564:LA347_RS01865
uniprot id: A0A2S7SP22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

564:LA347 RS20545
gene id: 564:LA347_RS20545
uniprot id: A0A7K4HU26
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MdcC family.
messages: Covalently binds the prosthetic group of malonate decarboxylase.
messages: Cytoplasm
messages: Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.

564:LA347 RS15060
gene id: 564:LA347_RS15060
uniprot id: A0A564V097
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT.
messages: Component of the preprimosomal complex composed of one monomer of PriC and DnaT, two monomers of PriA, two dimers of PriB and one hexamer of DnaB. Upon transient interaction with DnaG it forms the primosome.

564:LA347 RS04610
gene id: 564:LA347_RS04610
uniprot id: A0A7K4I2F6
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

564:LA347 RS18360
gene id: 564:LA347_RS18360
uniprot id: A0A7L6W5L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAP transporter large permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: The complex comprises the extracytoplasmic solute receptor protein and the two transmembrane proteins.

564:LA347 RS05335
gene id: 564:LA347_RS05335
uniprot id: A0A564UUU5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

564:LA347 RS15225
gene id: 564:LA347_RS15225
uniprot id: A0A7L6VRF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

564:LA347 RS05575
gene id: 564:LA347_RS05575
uniprot id: A0A7K4I2R1
names: Function
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.
messages: Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA.

564:LA347 RS02790
gene id: 564:LA347_RS02790
uniprot id: A0A7K4I2T5
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS07935
gene id: 564:LA347_RS07935
uniprot id: A0A7K4I1A8
names: Similarity
messages: Belongs to the pyruvate kinase family.

564:LA347 RS03580
gene id: 564:LA347_RS03580
uniprot id: A0A7W3ES67
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

564:LA347 RS16960
gene id: 564:LA347_RS16960
uniprot id: A0A7K4HVE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

564:LA347 RS09325
gene id: 564:LA347_RS09325
uniprot id: A0A7K4HZG0
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

564:LA347 RS15660
gene id: 564:LA347_RS15660
uniprot id: A0A7K4HW65
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

564:LA347 RS16470
gene id: 564:LA347_RS16470
uniprot id: A0A7L6RQE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

564:LA347 RS17635
gene id: 564:LA347_RS17635
uniprot id: A0A564V255
names: Similarity
messages: Belongs to the transposase 7 family.

564:LA347 RS13930
gene id: 564:LA347_RS13930
uniprot id: A0A7W3EHN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

564:LA347 RS08975
gene id: 564:LA347_RS08975
uniprot id: A0A7L6VGV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

564:LA347 RS17235
gene id: 564:LA347_RS17235
uniprot id: A0A2S7SHJ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

564:LA347 RS07145
gene id: 564:LA347_RS07145
uniprot id: A0A7K4I103
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.

564:LA347 RS11360
gene id: 564:LA347_RS11360
uniprot id: A0A7K4HYG3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Membrane
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

564:LA347 RS17220
gene id: 564:LA347_RS17220
uniprot id: A0A564UDZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

564:LA347 RS02915
gene id: 564:LA347_RS02915
uniprot id: A0A2S7SNW4
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

564:LA347 RS03960
gene id: 564:LA347_RS03960
uniprot id: A0A7K4I2B8
names: Similarity
messages: Belongs to the UPF0265 family.

564:LA347 RS12405
gene id: 564:LA347_RS12405
uniprot id: A0A2S7SHB6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS14780
gene id: 564:LA347_RS14780
uniprot id: A0A7K4HWN4
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

564:LA347 RS00870
gene id: 564:LA347_RS00870
uniprot id: A0A7K4HS44
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

564:LA347 RS18190
gene id: 564:LA347_RS18190
uniprot id: A0A7K4HVI7
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

564:LA347 RS07470
gene id: 564:LA347_RS07470
uniprot id: A0A7K4I0N8
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.

564:LA347 RS20265
gene id: 564:LA347_RS20265
uniprot id: A0A7K4HTJ7
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS11610
gene id: 564:LA347_RS11610
uniprot id: A0A2S7SBW8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

564:LA347 RS05515
gene id: 564:LA347_RS05515
uniprot id: A0A7K4I2U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

564:LA347 RS19730
gene id: 564:LA347_RS19730
uniprot id: A0A2S7SDQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

564:LA347 RS15280
gene id: 564:LA347_RS15280
uniprot id: A0A7W3EH86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

564:LA347 RS07280
gene id: 564:LA347_RS07280
uniprot id: A0A7K4I1Q8
names: Similarity
messages: Belongs to the peptidase C40 family.

564:LA347 RS20030
gene id: 564:LA347_RS20030
uniprot id: A0A7L6RZB9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

564:LA347 RS15455
gene id: 564:LA347_RS15455
uniprot id: A0A7K4HWA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

564:LA347 RS21225
gene id: 564:LA347_RS21225
uniprot id: A0A7K4HT13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

564:LA347 RS06855
gene id: 564:LA347_RS06855
uniprot id: A0A7L6S8B7
names: Similarity
messages: Belongs to the peptidase S1B family.

564:LA347 RS08770
gene id: 564:LA347_RS08770
uniprot id: A0A7K4HZQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

564:LA347 RS06470
gene id: 564:LA347_RS06470
uniprot id: A0A564S6Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS12685
gene id: 564:LA347_RS12685
uniprot id: A0A7K4HYR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0294 family.
messages: Cytoplasm

564:LA347 RS07815
gene id: 564:LA347_RS07815
uniprot id: A0A7W3EJW0
names: Similarity
messages: Belongs to the peptidase S41A family.

564:LA347 RS19615
gene id: 564:LA347_RS19615
uniprot id: A0A7K4HTW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
messages: Cell inner membrane
messages: Interacts with the regulatory subunit KefG.
messages: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.

564:LA347 RS20565
gene id: 564:LA347_RS20565
uniprot id: A0A7W3EL02
names: Similarity
messages: Belongs to the YkuD family.

564:LA347 RS09720
gene id: 564:LA347_RS09720
uniprot id: A0A7W3EPW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedD family.
messages: Cell inner membrane
messages: Non-essential cell division protein that could be required for efficient cell constriction.
messages: The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring.

564:LA347 RS17315
gene id: 564:LA347_RS17315
uniprot id: A0A7L6W3T3
names: Similarity
messages: Belongs to the UPF0167 family.

564:LA347 RS16410
gene id: 564:LA347_RS16410
uniprot id: A0A2S7SIL1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Does not bind DNA by a helix-turn-helix motif.
messages: Homodimer.
messages: This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.

564:LA347 RS01070
gene id: 564:LA347_RS01070
uniprot id: A0A7K4HSJ9
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

564:LA347 RS21890
gene id: 564:LA347_RS21890
uniprot id: A0A564TBK7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

564:LA347 RS07545
gene id: 564:LA347_RS07545
uniprot id: A0A8E4N5M5
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

564:LA347 RS05925
gene id: 564:LA347_RS05925
uniprot id: A0A7K4I2J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Membrane
messages: Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.

564:LA347 RS01330
gene id: 564:LA347_RS01330
uniprot id: A0A7K4HSE7
names: Similarity
messages: Belongs to the Hha/YmoA/Cnu family.

564:LA347 RS09700
gene id: 564:LA347_RS09700
uniprot id: A0A7W3EJ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

564:LA347 RS13180
gene id: 564:LA347_RS13180
uniprot id: A0A7K4HY77
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS16125
gene id: 564:LA347_RS16125
uniprot id: A0A7K4HVY4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

564:LA347 RS14765
gene id: 564:LA347_RS14765
uniprot id: A0A564SXW2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cytochrome b562 family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.
messages: Electron-transport protein of unknown function.

564:LA347 RS17340
gene id: 564:LA347_RS17340
uniprot id: A0A8E4N886
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS22275
gene id: 564:LA347_RS22275
uniprot id: A0A2S7SAN6
names: Similarity
messages: Belongs to the aminoglycoside phosphotransferase family.

564:LA347 RS18460
gene id: 564:LA347_RS18460
uniprot id: A0A2S7SDI2
names: Subcellular Location Annotation
messages: Cytoplasm

564:LA347 RS18005
gene id: 564:LA347_RS18005
uniprot id: A0A7L6ZW83
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

564:LA347 RS21725
gene id: 564:LA347_RS21725
uniprot id: A0A2S7SF52
names: Similarity
messages: Belongs to the YggT family.

564:LA347 RS19855
gene id: 564:LA347_RS19855
uniprot id: A0A2S7SDM2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

564:LA347 RS09730
gene id: 564:LA347_RS09730
uniprot id: A0A2S7SMK9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

564:LA347 RS15720
gene id: 564:LA347_RS15720
uniprot id: A0A7K4HW59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS02795
gene id: 564:LA347_RS02795
uniprot id: A0A7K4I2U8
names: Similarity
messages: Belongs to the peptidase C40 family.

564:LA347 RS17935
gene id: 564:LA347_RS17935
uniprot id: A0A7W3HX97
names: Similarity
messages: Belongs to the PrpF family.

564:LA347 RS19770
gene id: 564:LA347_RS19770
uniprot id: A0A2S7SDM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

564:LA347 RS07755
gene id: 564:LA347_RS07755
uniprot id: A0A7K4I0A1
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS14000
gene id: 564:LA347_RS14000
uniprot id: A0A8E4N4W3
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

564:LA347 RS18195
gene id: 564:LA347_RS18195
uniprot id: A0A7K4HUV4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS16860
gene id: 564:LA347_RS16860
uniprot id: A0A2S7SHQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

564:LA347 RS16450
gene id: 564:LA347_RS16450
uniprot id: A0A7K4HVU6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: By heat shock.
messages: Cytoplasm

564:LA347 RS08565
gene id: 564:LA347_RS08565
uniprot id: A0A2S7SJV8
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates exclusively with 100S ribosomes.
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes). May form immature 90S particles, which are converted to mature 100S ribosomes by the hibernation promoting factor Hpf.
messages: Induced during stationary growth phase.

564:LA347 RS08725
gene id: 564:LA347_RS08725
uniprot id: A0A7K4I0V2
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS13725
gene id: 564:LA347_RS13725
uniprot id: A0A2S7SJ63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

564:LA347 RS18045
gene id: 564:LA347_RS18045
uniprot id: A0A7K4HVU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

564:LA347 RS20345
gene id: 564:LA347_RS20345
uniprot id: A0A7K4HTH9
names: Similarity
messages: Belongs to the BolA/IbaG family.

564:LA347 RS18555
gene id: 564:LA347_RS18555
uniprot id: A0A2S7SDN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

564:LA347 RS06135
gene id: 564:LA347_RS06135
uniprot id: A0A7L6VXY0
names: Function
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

564:LA347 RS05245
gene id: 564:LA347_RS05245
uniprot id: A0A7K4I2X2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism.

564:LA347 RS17110
gene id: 564:LA347_RS17110
uniprot id: A0A7L6S0R6
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS04055
gene id: 564:LA347_RS04055
uniprot id: A0A7K4I2B4
names: Subcellular Location Annotation
messages: Bacterial microcompartment

564:LA347 RS05485
gene id: 564:LA347_RS05485
uniprot id: A0A7K4I1P3
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RssB family.
messages: Binds to RpoS.
messages: Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.
messages: Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.

564:LA347 RS15600
gene id: 564:LA347_RS15600
uniprot id: A0A7L6S2X3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

564:LA347 RS06935
gene id: 564:LA347_RS06935
uniprot id: A0A7L6ZQD6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

564:LA347 RS12105
gene id: 564:LA347_RS12105
uniprot id: A0A7W3EP25
names: Subcellular Location Annotation
messages: Membrane

564:LA347 RS10685
gene id: 564:LA347_RS10685
uniprot id: A0A2S7SMU1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

564:LA347 RS05300
gene id: 564:LA347_RS05300
uniprot id: A0A7K4I2W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

564:LA347 RS00050
gene id: 564:LA347_RS00050
uniprot id: A0A7L6VNB6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS15370
gene id: 564:LA347_RS15370
uniprot id: A0A2S7SIN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

564:LA347 RS09645
gene id: 564:LA347_RS09645
uniprot id: A0A7K4HZ92
names: Similarity
messages: Belongs to the Nudix hydrolase family.

564:LA347 RS16440
gene id: 564:LA347_RS16440
uniprot id: A0A7K4HVU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsN family.
messages: Cell inner membrane
messages: Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
messages: Interacts with FtsA via its N-terminal cytoplasmic domain.

564:LA347 RS02820
gene id: 564:LA347_RS02820
uniprot id: A0A7K4I356
names: Similarity
messages: Belongs to the elongation factor P family.

564:LA347 RS20085
gene id: 564:LA347_RS20085
uniprot id: A0A7T4TEZ7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

564:LA347 RS00065
gene id: 564:LA347_RS00065
uniprot id: A0A7K4HSJ4
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

564:LA347 RS21500
gene id: 564:LA347_RS21500
uniprot id: A0A7K4HSZ9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family. HybF subfamily.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

564:LA347 RS12950
gene id: 564:LA347_RS12950
uniprot id: A0A2S7SCT4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

564:LA347 RS10745
gene id: 564:LA347_RS10745
uniprot id: A0A2S7SN24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity. Interacts with IscU.

564:LA347 RS21290
gene id: 564:LA347_RS21290
uniprot id: A0A7K4HT19
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

564:LA347 RS13460
gene id: 564:LA347_RS13460
uniprot id: A0A7K4HXB7
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

564:LA347 RS17630
gene id: 564:LA347_RS17630
uniprot id: A0A2S7SE40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

564:LA347 RS19050
gene id: 564:LA347_RS19050
uniprot id: A0A2S7SG85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

564:LA347 RS11325
gene id: 564:LA347_RS11325
uniprot id: A0A7K4HYF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm
messages: Monomer.

564:LA347 RS16140
gene id: 564:LA347_RS16140
uniprot id: A0A564UZB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

564:LA347 RS04985
gene id: 564:LA347_RS04985
uniprot id: A0A7K4I213
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

564:LA347 RS21775
gene id: 564:LA347_RS21775
uniprot id: A0A7K4HSR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

564:LA347 RS13865
gene id: 564:LA347_RS13865
uniprot id: A0A7L6RRQ1
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. GpmB subfamily.

564:LA347 RS07970
gene id: 564:LA347_RS07970
uniprot id: A0A4Y5RMJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RuvA family.
messages: Forms a complex with RuvB.
messages: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.

564:LA347 RS11930
gene id: 564:LA347_RS11930
uniprot id: A0A7W3HYS0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

564:LA347 RS16555
gene id: 564:LA347_RS16555
uniprot id: A0A7L6VQR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

564:LA347 RS17620
gene id: 564:LA347_RS17620
uniprot id: A0A2S7SEN1
names: Similarity
messages: Belongs to the thioredoxin family.

564:LA347 RS01180
gene id: 564:LA347_RS01180
uniprot id: A0A7W3HVZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

564:LA347 RS01075
gene id: 564:LA347_RS01075
uniprot id: A0A7W3ET31
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

564:LA347 RS04675
gene id: 564:LA347_RS04675
uniprot id: A0A7K4I2D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CsgA/CsgB family.
messages: Fimbrium

564:LA347 RS16535
gene id: 564:LA347_RS16535
uniprot id: A0A7K4HVM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

564:LA347 RS02660
gene id: 564:LA347_RS02660
uniprot id: A0A7K4I394
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.
messages: Membrane

564:LA347 RS12890
gene id: 564:LA347_RS12890
uniprot id: A0A7K4HXM3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

564:LA347 RS15305
gene id: 564:LA347_RS15305
uniprot id: A0A2S7SIU9
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

564:LA347 RS17470
gene id: 564:LA347_RS17470
uniprot id: A0A7K4HV34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system).

564:LA347 RS02145
gene id: 564:LA347_RS02145
uniprot id: A0A2S7SNX8
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: The heme is bound between the two transmembrane subunits.

564:LA347 RS07605
gene id: 564:LA347_RS07605
uniprot id: A0A7L6S917
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

564:LA347 RS14365
gene id: 564:LA347_RS14365
uniprot id: A0A7K4HWW9
names: Function
names: Similarity
messages: Belongs to the DnaT family.
messages: This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'.

564:LA347 RS07945
gene id: 564:LA347_RS07945
uniprot id: A0A7K4I1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M23B family.
messages: Membrane

564:LA347 RS07990
gene id: 564:LA347_RS07990
uniprot id: A0A7K4I071
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

564:LA347 RS09550
gene id: 564:LA347_RS09550
uniprot id: A0A2S7SMI2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

564:LA347 RS14620
gene id: 564:LA347_RS14620
uniprot id: A0A7K4HWZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

564:LA347 RS06640
gene id: 564:LA347_RS06640
uniprot id: A0A7K4I100
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

564:LA347 RS09785
gene id: 564:LA347_RS09785
uniprot id: A0A7K4HZF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS07560
gene id: 564:LA347_RS07560
uniprot id: A0A7K4I0D2
names: Similarity
messages: Belongs to the asparaginase 1 family.

564:LA347 RS07595
gene id: 564:LA347_RS07595
uniprot id: A0A7T4NBL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

564:LA347 RS10805
gene id: 564:LA347_RS10805
uniprot id: A0A7K4HZE2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

564:LA347 RS09760
gene id: 564:LA347_RS09760
uniprot id: A0A7K4HZ79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YfcJ family.
messages: Cell inner membrane
messages: Membrane

564:LA347 RS08815
gene id: 564:LA347_RS08815
uniprot id: A0A2S7SKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

564:LA347 RS09605
gene id: 564:LA347_RS09605
uniprot id: A0A7K4I053
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

564:LA347 RS04730
gene id: 564:LA347_RS04730
uniprot id: A0A7K4I387
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).
messages: Cell inner membrane

564:LA347 RS14960
gene id: 564:LA347_RS14960
uniprot id: A0A7K4HWN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

564:LA347 RS08205
gene id: 564:LA347_RS08205
uniprot id: A0A7L6VJ06
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

564:LA347 RS10750
gene id: 564:LA347_RS10750
uniprot id: A0A2S7SMT9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.
messages: Homodimer; may form tetramers and higher multimers.
messages: Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.

564:LA347 RS07250
gene id: 564:LA347_RS07250
uniprot id: A0A7L6VME1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

564:LA347 RS14900
gene id: 564:LA347_RS14900
uniprot id: A0A7L6VTD6
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Catalyzes the phosphorylation of D-allose to D-allose 6-phosphate.

564:LA347 RS13255
gene id: 564:LA347_RS13255
uniprot id: A0A7L6VSB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

564:LA347 RS07215
gene id: 564:LA347_RS07215
uniprot id: A0A7K4I0R8
names: Similarity
messages: Belongs to the HesB/IscA family.

564:LA347 RS07550
gene id: 564:LA347_RS07550
uniprot id: A0A8E4N608
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S49 family.
messages: Cell inner membrane

564:LA347 RS15050
gene id: 564:LA347_RS15050
uniprot id: A0A2S7SIU7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

564:LA347 RS19760
gene id: 564:LA347_RS19760
uniprot id: A0A2S7SDL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

564:LA347 RS19810
gene id: 564:LA347_RS19810
uniprot id: A0A2S7SDK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

564:LA347 RS07745
gene id: 564:LA347_RS07745
uniprot id: A0A7K4I1D5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

564:LA347 RS08165
gene id: 564:LA347_RS08165
uniprot id: A0A7B5U4W0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
messages: Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine.
messages: Homodimer.

564:LA347 RS13920
gene id: 564:LA347_RS13920
uniprot id: A0A7W3EHK0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
messages: Cytoplasm
messages: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Monomer.

564:LA347 RS11405
gene id: 564:LA347_RS11405
uniprot id: A0A7K4HZ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.